1)Endomorphin-1内吗啡肽-1
1.Synthesis of endomorphin-1 with mixed anhydride method;混合酸酐法合成内吗啡肽-1
2.Modification of Endomorphin-1 to Enhance the Blood-brain Barrier Permeability: Design, Synthesis and Biological Activity Characterization;内吗啡肽-1衍生多肽的设计合成、生物学活性及血脑屏障通透性研究
英文短句/例句
1.An Experimental Study on EM-1 Inducing K562 Cell Apoptosis;内吗啡肽-1诱导K562细胞凋亡的实验研究
2.Study the Brain-targeting Nanoparticles of HDAPC, an Analog of EM-1内吗啡肽-1类似物HDAPC的脑靶向纳米粒研究
3.Synthesis and Pharmacological Activity of Novel Endomorphin-1 Analogues with Combined Chemical Modification;组合化学修饰内吗啡肽-1类似物的合成和药理学活性研究
4.EM-1's Influence on the Hemopoiesis Control of the Bone Marrow Stromal Cell内吗啡肽-1对正常骨髓基质细胞造血调控的影响
5.Analgesic activity of polybutylcyanoacrylate nanoparticles of HDAPC,an analog of Endomorphin-1内吗啡肽-1类似物HDAPC聚氰基丙烯酸正丁酯纳米粒的镇痛活性
6.Modification of Endomorphin-1 to Enhance the Blood-brain Barrier Permeability: Design, Synthesis and Biological Activity Characterization;内吗啡肽-1衍生多肽的设计合成、生物学活性及血脑屏障通透性研究
7.Structure-Activity Study and Characterization of Opioid Activities of Endomorphin-1 and Endomorphin-2 Analogs with C-Terminal ModificationsC-末端修饰的内吗啡肽-1和-2类似物设计合成、构效关系及阿片活性研究
8.Expression of orphanin FQ in the brain of acute morphine tolerant rats急性吗啡耐受大鼠脑内孤啡肽的表达
9.CoMFA Studies of Endomorphin-2 Analogues;内吗啡肽2类似物的CoMFA研究
10.Finally,the research of cerebral morphia peptide will deepen our understanding to aesthetic education.三是脑内吗啡肽的研究对美育作用认识的深化。
11.Synthesis and Analgesic Activities of Endomorphin-2 and Its Analogues;内吗啡肽-2及其类似物的合成与镇痛活性研究
12.The Anti-morphine-physical-dependence Effect of Melatonin and Its Relation to β-endorphin in CNS;褪黑素抗吗啡身体依赖作用及其与中枢β-内啡肽的关系
13.The role of beta-endorphin in protective effect of intracerebroventricular morphine preconditioning against myocardial post-ischemic injury in ratsβ-内啡肽在中枢吗啡预处理减轻大鼠心肌缺血后损伤中的作用
14.Melatonin enhances the expression of β-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice褪黑素增加吗啡依赖小鼠下丘脑弓状核β-内啡肽的表达(英文)
15.Pharmacological Study on Endogenous Opioid Peptide (Endomorphins) and Natural Polyphenol Compound (Caffeic Acid Phenethyl Ester);内源性阿片肽内吗啡肽与天然多酚类化合物咖啡酸苯乙酯的药理学活性研究
16.Analgesic Effects of Spinal Endomorphine on Peripheral Inflammation--Behavioral Study;内吗啡肽在炎性痛动物脊髓内镇痛作用的行为学观察
17.Studies of the in Vivo Antioxidant Properties and the in Vitro Oxidative Metabolites of Endomorphins内吗啡肽体内抗氧化活性及其体外氧化代谢产物的研究
18.Differential reversal effect of intrathecal bovine adrenal medulla peptide 22 on morphine tolerance in rats椎管内注射牛肾上腺髓质22肽差异性翻转吗啡耐受作用
相关短句/例句
endomorphin 1内吗啡肽1
3)endomorphin内吗啡肽
1.Effect of Endomorphin on Contractile Response of Colon Muscle Strips in Cathartic Colon Rats in Vitro;内吗啡肽对“泻剂结肠”大鼠离体肠肌条收缩反应的影响
2.Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats;侧脑室注射内吗啡肽-1对大鼠心功能的影响
3.Analgesic mechanism of endomorphin in the superficial laminae of the spinal dorsal horn;内吗啡肽在脊髓背角浅层的镇痛机制
4)Endomorphins内吗啡肽
1.Development of Potent Endomorphins Analogs Using Atypical Conformationally Constrained C-Terminus and Characterization of Opioid Activities of Endomorphins and Their Analogs Both in Vivo and in Vitro;C-末端空间立体构象限制的内吗啡肽的构建以及内吗啡肽及其类似物的生理、药理活性研究
2.Structure-activity Relationships of the Novel Dimeric, Side Chain and C-terminal Modified Analogs of Endomorphins;二聚化以及侧链和碳末端修饰的内吗啡肽类似物的构效关系研究
3.Alterations of the Regulatory Function of Endomorphins on the Cardiovascular System and Bronchoconstriction in Type I Diabetes;糖尿病病理状态下内吗啡肽对心血管系统及支气管收缩调节功能的变化
5)endomorphin-2内吗啡肽-2
1.Endomorphins including endomorphin-1(H-Tyr-Pro-Trp-Phe-NH_2, EM1) andendomorphin-2(H-Tyr-Pro-Phe-Phe-NH_2, EM2) were discovered, isolated anddemonstrated to have high selectivity and affinity forμ-opioid receptors in 1997.内吗啡肽是一种具有吗啡活性的内源性四肽，包括内吗啡肽-1(H-Tyr-Pro-Trp-Phe-NH_2)和内吗啡肽-2(H-Tyr-Pro-Phe-Phe-NH_2)。
2.The tetrapeptide of endomorphin-2, a strong agonist of the u-acceptor with high affinity and selectivity, was synthesized from L-tyrosine、 L-proline and L-phenylalanine by liquid phase condensation.采用先合成两个二肽片段，再合成四肽的合成策略，以酪氨酸(L-Tyr)、脯氨酸(L-Pro)、苯丙氨酸(L-Phe)为起始原料，液相条件下合成出内吗啡肽-2(endomorphin-2，H-Tyr-Pro-Phe-Phe-NH_2)三氟乙酸盐。
3.Two potent endogenous opioid peptides,endomorphin-1(EM1;H-Tyr-Pro-Trp-Phe-NH_2) and endomorphin-2(EM2;H-Tyr-Pro-Phe-Phe-NH_2),which showed high affinity and selectivity toward theμ-opioid receptor,were isolated from bovine brain in 1997.1997年,内吗啡肽-1(H-Tyr-ProTrp-Phe-NH_2)和内吗啡肽-2(H-Tyr-Pro-Phe-Phe-NH_2)从牛脑中分离提纯得到,它们是对μ-阿片受体具有高亲和性和选择性的内源性阿片肽。
6)endomorphin 2内吗啡肽2
延伸阅读
盐酸吗啡,美施康定(吗啡控释片),美菲康,吗啡药物名称：吗啡英文名：Morphine别名：盐酸吗啡,美施康定(吗啡控释片),美菲康,吗啡外文名：Morphine ,Morphine Hydrochlride, Morphina, Morphinum适应症：1.镇痛：有强大的镇痛作用，对一切疼痛均有效，对持续性钝痛比间断性锐痛及内脏绞痛效果强。１次给药，镇痛作用持续４～８小时，故仅用于创伤、手术、烧伤、心肌梗塞等引起的剧痛。 2.镇静：在镇痛的同时有明显镇静作用，有时产生欣快感，可改善疼痛病人的紧张情绪。 3.抑制呼吸：可抑制呼吸中枢，降低呼吸中枢对二氧化碳的敏感性。 4.镇咳：可抑制咳嗽中枢，产生镇咳作用。因有成瘾性，并不适用于临床。 5.对平滑肌的作用：可使消化道平滑肌兴奋，致使便秘；并使胆道、输尿管、支气管平滑肌张力增加。 6.心血管系统：可促进内源性组胺的释放而使外周血管扩张、血压下降；使脑血管扩张，颅压增高。 7.镇吐：亦因有成瘾性而不适用于临床。 用量用法： 皮下注射或口服：每次５～１０ｍｇ，１日１～３次。极量：皮下注射，每次２０ｍｇ，１日６０ｍｇ；口服每次３０ｍｇ，１日１００ｍｇ。 注意事项： 1.连续使用可成瘾，需慎用。 2.婴儿及哺乳妇女忌用，临产妇女禁用（因可经乳腺排出及分布至胎盘，可抑制新生儿及婴儿呼吸）。 3.可引起眩晕、呕吐及便秘等不良反应。 4.慢性阻塞性肺疾患、支气管哮喘、肺原性心脏病禁用；急性左心衰竭晚期并出现呼吸衰竭时忌用。 5.颅内高压、颅脑损伤等病人禁用。 6.肝功能减退者忌用。 7.胆绞痛、肾绞痛需与阿托品合用，单用本品反而加剧疼痛。 8.在疼痛原因未明确前，忌用本品，以防掩盖症状，贻误诊治。 9.对呼吸抑制的程度与使用吗啡的剂量并行，过大剂量可致急性吗啡中毒病人出现昏睡、呼吸减慢、瞳孔缩小针尖样，进而可致呼吸麻痹而死亡。 规格：注射液：每支５ｍｇ（0.50ｍｌ）；１０ｍｇ（１ｍｌ）。 片剂：每片５ｍｇ；１０ｍｇ。 类别：镇痛药\阿片受体激动剂
