乳癌的预后的制作方法

专利名称：乳癌的预后的制作方法
技术领域：
本发明涉及基于生物样本基因表达模式的乳癌的预后。
背景技术：
在乳癌中，预后主要由引流腋淋巴结中转移瘤的存在或不存在来决定。但是，在大约三分之一的淋巴结阴性的患有乳癌的妇女中，疾病复发，并且大约三分之一的淋巴结阳性的病人在经过局部或区域治疗10年后都没有再复发。此外，由于对筛选模式认识的增加和更广泛使用，乳癌的早期诊断的比例正逐步升高。对这些病人的系统治疗的普遍应用经常导致过度治疗。根据St Gallen和美国国立卫生研究所(NIH)的统计，70-80％的第I和第II阶段的病人在没有辅助治疗的情况下将不会发展远端转移瘤，并可能遭受潜在的副作用。这些数据强调了对更加灵敏和特异性预后化验的需要，其中这些化验可能显著地减少接受不必要治疗的病人的人数。
已经在许多研究中发现肿瘤大小和淋巴或血管的入侵具有显著的预后值。定量的病理特征，即细胞核形态、DNA含量和增殖活性能进一步划分高机率的微转移瘤。已知的影响病人结果的分子遗传改变包括Her2/NEU的过表达、DNA扩增、p53突变、ER/PR状态、uPA和PAI表达。由于转移的级联是一个包括若干步骤的复杂过程，因此对肿瘤发展起作用的单个因子对预后评估来说具有一定的限制。本发明的基因表达模式将提供增强的预后能力。

发明内容
本发明涉及一种评估被诊断为或当作乳癌治疗的病人中乳癌复发或转移的可能性的方法。该方法涉及基因表达模式的分析。
在本发明的一个方面中，所述的基因表达模式包括56个基因，在本发明的另一个方面中，所述的基因表达模式分别包括至少45个基因、26个基因、13个基因和6个基因。
用于实施本发明的方法的制品也是本发明的一个方面。这些制品包括基因表达模式，或固定于机器可读介质如计算机可读介质上的基因表达模式的表示物。
用于鉴定基因表达模式的制品，也可以包括用于捕获和/或显示基因表达的存在、不存在或程度的基体或表面(如微阵列)。
本发明的另一个方面为一种试剂盒，其包括用于对乳癌复发或转移预后进行基因表达分析的试剂。
附图简述

图1是根据实施例中描述的训练组的病人资料构建的一个标准的Kaplan-Meier方块图。
图2是根据实施例中描述的测试组的病人资料构建的一个标准的Kaplan-Meier方块图。
图3是采用56-基因表达模式根据54个病人(训练和测试资料结合)的病人资料构建的一个标准的Kaplan-Meier方块图。
发明详述在组织样品中，仅仅是特定核酸序列的存在或缺乏很少被认为具有诊断或预后的价值。另一方面，各种有关蛋白质，多肽或mRNA表达的信息正越来越受到重视。基因组内仅仅存在具有表达蛋白质，多肽或mRNA潜力(这种序列被称为“基因”)的核酸序列，不能确定蛋白质，多肽或mRNA是否会在特定细胞中表达。一个确定的基因能否表达蛋白质，多肽或mRNA以及这种表达发生的程度，全然地由多种复杂因素决定。不考虑理解和评估这些因子的困难，检测基因表达能为如肿瘤发生，转移，细胞凋亡及其它临床相关现象等重要事件的出现提供有用信息。在基因表达模式中可以发现基因激活或失活程度的相对指标。本发明的基因表达模式用于为乳癌病人提供预后和治疗。
样本制备需要收集病人样本。本发明方法中使用的病人样本是那些被怀疑含有疾病细胞的样本，如从乳腺淋巴节样本或外科切除得到的上皮细胞的样本。一种获得被怀疑样本的有用的技术是激光捕获微切片法(LCM)。LCM技术提供了一种筛选要研究的细胞的方法，并最小化了由细胞类型的不均一导致的易变性。因此，正常细胞和癌症细胞间在基因表达上的中度或细小的差异都可以被容易地检测到。在一个优选的方法中，所述样本包括从外周血中提取的循环系统上皮细胞。这些样品可以根据多种方法获得，但是最优选的方法为磁分离技术，该技术描述于Imunivest公司的美国专利US6136182中，这里也通过参考文献引入。一旦获得了含有感兴趣细胞的样本，就可以提取RNA并进行扩增，获得合适的文库(portfolios)中基因的基因表达模式，优选的是通过微阵列获得。
建立基因表达模式的优选的方法，包括确定编码蛋白质或多肽的基因产生的RNA的量。这可通过反转录酶PCR(RT-PCR)，竞争性RT-PCR，实时RT-PCR，差示RT-PCR，Northern印迹分析和其它的相关实验来完成。虽然可以用单个的PCR反应来完成这些技术，但最好扩增从mRNA产生的互补DNA(cDNA)或互补RNA(cRNA)，并通过微阵列法进行分析。各种不同的阵列构型和生产方法，对于本领域的普通技术人员来说是已知的，并描述于美国专利，如5445934；5532128；5556752；5242974；5384261；5405783；5412087；5424186；5429807；5436327；5472672；5527681；5529756；5545531；5554501；5561071；5571639；5593839；5559695；5624711；5658734；和5700637；它们的说明书也结合用于参考在这里。
微阵列技术可以允许同时测量成千的基因的处于稳定状态的mRNA水平，由此它为确定如失控的细胞增值的启动，抑制，或调节的效果提供了一个强有力的工具。目前广泛使用的为两种微阵列技术。第一种是cDNA阵列，第二种是寡核苷酸阵列。虽然这些芯片存在构造差异，但是本质上所有的下游数据分析和输出是相同的。这些分析的结果，典型地是通过测定从用于检测与微阵列上已知位置的核酸序列杂交的样本cDNA序列的标记探针接收的信号强度而获得的。典型地，信号强度与在样本细胞中表达的cDNA和相应的mRNA的量成比例。大量的这种技术是可以获得和使用的。用于检测基因表达的优选的方法参见美国专利，Linsley等的6271002；Friend等的6218122；Peck等的6218114；Wang等的6004755，这些发明的说明书在此也结合用于参考。
可以通过比较强度来分析表达水平。最好建立一个测试样本与对照样本中基因表达强度的比值矩阵。例如，可以把疾病组织的基因表达强度与从相同类型的正常组织中得到的表达强度进行比较(例如，得病的乳腺组织样本与正常的乳腺组织样本)。这些表达强度的比值显示了测试样本与对照样本之间在基因表达中的倍数变化。
基因表达模式也可用很多方式显示。最常用的方法是将原始荧光强度或比值矩阵布置为树突状图形，其中的列表示测试样本，行表示基因。这样排列数据以便具有相似表达模式的基因能彼此邻近。每个基因的表达比例用一种颜色显示。例如，小于1的比率(表示下调)可以用图谱的蓝色部分表示，而大于1的比率(表示上调)可用图谱的红色部分来表示。商业用途的计算机软件程序可用于显示这种数据，这些软件包括来自Silicon Genetics公司的“GENESPRINT”，以及来自Partek公司的“DISCOVERY”和“INFER”软件。
实施例中描述了本发明的方法中使用的调节基因。相对于那些没有复发的病人，在乳癌复发的病人中差异表达的基因不是上调就是下调。上调和下调是相对的术语，其含义为在相对于特定基线的基因表达量中可检测到的差异(超出检测系统的噪音影响)。在这种情况下，基线是测量的非复发病人的基因表达量。用同样方法测量，疾病细胞(来自复发病人)中感兴趣的基因，相对于基线水平不是上调就是下调。在上下文中，疾病是指机体状态发生改变，从而打断或扰乱，或者可能扰乱机体功能的正常发挥，例如在细胞的非控制增殖中所发生的。当某人的基因型或表型的某个方面和某种疾病存在一致的时候，他就被诊断为患了该病。但是，作出一个诊断或预后判断包括疾病/状况问题的测定，如测定复发或转移的可能性和治疗的监测。在治疗监测中，通过比较基因随时间的表达，来确定基因表达模式是否已经改变了，或者正在改变到和正常组织更一致的模式来考虑一个确定疗程的效果，从而作出临床判断。
更优选地，可以根据杂交微阵列探针的测量强度的倍数变化来辨别上调和下调的水平。一个2.0倍差异或小于0.5的p值有利于作出这种区分。也就是说，当说一个基因是在疾病/复发细胞中相对于正常/非复发细胞中差异表达的时，发现疾病细胞中产生比正常细胞至少多2倍，或强度小2倍的表达。倍数差异越大，用该基因作为诊断或预后工具就越有益。本发明的基因表达模式中选用的基因具有能产生可以明显区别于正常或非调节基因的信号的表达水平，其表达量超过了使用临床试验仪器测定所产生的背景。
统计值可信赖地用于将调节基因与非调节基因和噪音区分开。统计试验发现在不同组样本之间差异最显著的基因。斯徒登特t检验是可用于发现两组之间有显著性差异的强有力统计测验的一个例子。P值越低，就越能说明基因在不同组之间的差异。不过，由于微阵列能一次测量多个基因，那么就需要同时进行数万个统计测验。因此，不可能仅由于偶然而看到小的p值，为此，可以使用Sidak校正和随机选择/变换试验进行调整。通过t-检验得到的p-值小于0.05表明基因存在显著性差异。在进行Sidak校正后p-值小于0.05是更强有力的证据。对于每组中的大量的样本来说，在随机选择/变换试验后p-值小于0.05是差异显著的最强有力的证据。
可以用于选择产生比非受调节基因和噪音更大的信号的基因的另一个参数为绝对信号差异测量值。优选地，受调节基因表达产生的信号，与正常的或非受调节基因(以绝对值为基础)相比至少有20％差异。更优选的是，这种基因产生的表达模式与正常的或非受调节基因的相比至少有30％的差异。
将基因分组，以便从同一组中获得的一组基因的信息可以为临床相关判断，如诊断、预后或治疗选择等提供可靠的基础。这些组的基因构成了本发明的基因文库。在此，由这些文库支持的判断涉及乳癌。对于大多数的诊断标记来说，常常希望用最少数量的标记就足以作出一个正确的医学判断。这就防止了需要进一步的分析导致的治疗延误以及时间和资源的不合理使用。
更优选地，建立基因文库，从而基因文库中的这些基因组合，显示出比单个基因或随机选择的基因组合具有更好的灵敏度和特异性。在本发明中，文库的灵敏度可以由基因在疾病状态相对于正常状态的表达中显示的倍数变化反映出来。特异性可以由感兴趣的条件和基因表达信号的相关性的统计测量值反映出来。例如，标准偏差可用作这种测量值。在考虑将一组基因包括在一个文库中时，表达测量中很小的标准偏差都与更大的特异性相关。其它变量如相关系数的测量在这里也可以使用。
建立基因表达文库的一个优选的方法是通过使用优化算法，如广泛用于建立股票投资库的平均方差算法。这种方法的详细描述见Tim Jatkoe等，2003年3月21日的提交的名称为“标记的选择”的专利申请(申请序列号为10/394087，在这里也结合用于参考)。实质上，这种方法要求建立一套输入值(金融应用中的股票，这里指检测的表达强度值)，并利用其优化接收到的回报值(例如产生的信号)，同时使回报值的变化最小化。很多商业软件程序可以用来进行这种操作。在整个该说明书中称为“Wagner软件”的“Wagner联合均方差优化应用程序”是优选的。这个软件使用“Wagner联合均方差优化库”的函数来测定有效边界和优化的文库。
使用这种类型的软件要求转换微阵列数据(即强度测定值)，以便当该软件用于所要的金融分析目的时，数据能作为股票回报值和风险测量值的输入值被处理。
文库的选择过程和未知量的表征概述如下1.选择基线组2.计算基线组样本中的每个基因的平均值和标准偏差3.计算每个基因的(X*标准偏差+平均值)。这是基线值，所有其它的样本将和它进行比较。X是一个严格变量，X值越高的比X值越低的更严格。
4.计算每个试验样本与在步骤3中计算的基线值的比值。
5.转换比值，使比值小于1的为负数(如使用底数为10的对数)(此时，下调基因正确地呈负值将对于MV最优化是必要的)。
6.把这些转换后的比值用作输入值，来替代软件应用中通常使用的资产回报值。
7.该软件将标绘出有效的边界，并沿着该有效边界的任何点返回优化的文库。
8.在有效边界上选择理想的返回值或方差。
9.通过将文库选择算法中产生的权重乘以每个基因的强度值，加和计算得到每个样本的文库值。
10.将基线组的平均文库值加上Y与基线组的文库值的标准偏差的乘积计算得到边界值。比该边界值大的比值将被划分为试验组。
11.任选的，可以重复该过程直到获得最好的预测准确度。
可选择地，可以通过鉴定那些有细小表达差异的基因来预先选择基因。在这种可选择的方法中，预选过程优选地基于1≤|(μt-μn)(σt+σn)|]]>给出的阈值为基础，其中μt是已知有疾病和病症的子集的平均值，μn是正常样本的子集的平均值，σt+σn代表合并的标准偏差。在根据如0.5≤|(μt-MAXn)(σt+σn)|]]>所述的关系来预选数据过程中，也可以使用噪音截止信号。这保证基于差异调节预选的基因具有临床上的显著性差异。也就是，超过了适于测定各种诊断参数的仪器产生的噪音水平。针对根据这些标准的每一个预选标记，构建了一个矩阵，其中列代表样本，行代表标记，而且每个元件都是根据关系 对该标记的表达进行归一化后所得到的强度测量值，其中I是强度测量值。
也能设置附加的边界条件来限定优化的文库。例如，文库大小可以被限定到一个固定范围或一定数量的标记。这可以通过使数据预选标准更严格(如以0.8≤|(μt-MAXn)(σt+σn)|]]>代替0.5≤|(μt-MAXn)(σt+σn)|,]]>)或通过使用编程特征如限制文库大小来实现。例如，可以设置边界条件，使得仅从最合适的10个基因中选择有效的边界线。也可以使用所有的预选基因来确定有效边界线，然后限定选择的基因的数量(例如，不超过10)。
选择文库的过程也可以包括启发式规则的应用。优选地，这些规则基于生物学和用于得到临床结果的技术的理解的基础上制定的。更优选地，它们也可用于从优化的方法中输出数据。例如，文库选择的平均方差方法能用于在患有乳癌的主体中大量差异表达的基因的微阵列数据。从该方法中得到的输出值将是一组经过优化的基因，其可包括一些既在外周血液中也在疾病组织中表达的基因。如果用于测试方法中的样本获自外周血液，而且在乳癌样本中差异表达的某些基因也能在外周血液中差异表达，那么就可以应用启发式规则，其中从排除了那些在外周血液中差异表达的基因之外的有效边界线中选择文库。当然，该规则可以在构建有效边界线前运用，如在数据预选期间运用该规则。
也可以运用与所论的生物学问题未必有联系的其它启发式规则。例如，可以运用该规则，从而只有特定百分比的文库能被特定的基因或基因群代表。商业上可用的软件，如Wagner软件，也易于适应这些类型的启发式规则。这也是有用的，例如，当除了准确度和精确度以外的因子(如预期的许可费)对包括一个或多个基因的需求有影响时。
本发明的一种方法包括比较各种基因(或文库)的基因表达模式来归预后的根源。组成文库的每个基因的基因表达模式被固定于如计算机可读介质的介质上。这可以采取多种形式。例如，可以建立一个表格，从而将指示疾病/复发的信号(例如，强度测量)范围输入其中。然后比较实际病人的数据和表格中的数值，从而确定病人样本是正常或还是患病的。在一个更为复杂的实施方式中，表达信号的模式(如荧光强度)以数字或图形方式记录。再将与病人样本相结合使用的基因文库的基因表达模式与上述表达模式比较。然后模式比较软件可用于确定病人样本是否为指示疾病复发的模式。当然，这些比较也可用于确定病人是否可能经历疾病复发。然后将样本表达模式与对照细胞文库相比较。如果样本表达模式与乳癌复发表达模式一致，那么在不存在相反的医学考虑的情况下对待该病人将象一个复发病人一样。如果样本表达模式与正常/对照细胞的表达模式一致，那么该病人被诊断为乳癌阴性。
许多公知的识别模式方法都可采用。下面的参考文献可以提供一些实例加权投票(Weighted Voting)Golub，TR.，Sclonim，DK.，Tamaya，P.，Huard，C.，Gaasenbeek，M.，Mesirov，JP.，Coller，H.，Loh，L.，Downing，JR.，Caligiuri，MA.，Bloomfield，CD.，Lander，ES.癌症的分子分类利用基因表达监视的分类发现和分类预测。科学(Science)286531-537，1999支持矢量机器(Support Vector Machines)Su，AI.，Welsh，JB.，Sapinoso，LM.，Kern，SG.，Dimitrov，P.，Lapp，H.，Schultz，PG.，Powell，SM，Moskaluk，CA.，Frierson，HF.Jr.，Hampton，GM.利用基因表达特征的人类癌症的分子分类。癌症研究(CancerResearch)617388-93，2001Ramaswamy，S.，Tamayo，P.，Rifkin，R.，Mukherjee，S.，Yeang，GH.，Angelo，M.，Ladd，C.，Reich，M.，Latulippe，E.，Mesirov，JP.，Poggio，T.，Gerald，W.，Loda，M.，Lander，ES.，Gould，TR.利用肿瘤基因表达特征的多种类癌症诊断。美国国家科学院院刊(Proceedingsofthe National Academy of Sciences of the USA)9815149-15154，2001K-最邻近值(K-nearest Neighbors)Ramaswamy，S.，Tamayo，P.，Rifkin，R.，Mukherjee，S.，Yeang，GH.，Angelo，M.，Ladd，C.，Reich，M.，Latulippe，E.，Mesirov，JP.，Poggio，T.，Gerald，W.，Loda，M.，Lander，ES.，Gould，TR.利用肿瘤基因表达特征的多种类癌症诊断。美国国家科学院院刊(Proceedingsofthe National Academy of Sciences ofthe USA)9815149-15154，2001相关系数(Correlation Coefficients)van’t Veer LJ，Dai H，van de Vijver MJ，He YD，Hart AA，Mao M，Peterse HL，vander KooyK，Marton MJ，Witteveen AT，Schreiber GJ，Kerkhoven RM，Roberts C，LinsleyPS，Bemards R，Friend SH.基因表达模式预测乳癌的临床结果。自然(Nature)2002Jan 31415(6871)530-6。
本发明的基因表达模式也可以与在癌症诊断，预后，或治疗监视中使用的其它非遗传诊断方法联合使用。例如，在一些情况下，把上述的基于基因表达诊断能力的方法与来自传统的标记，如血清蛋白标记的数据结合起来是有益的。这种标记的存在范围包括分析物，如带有显示更大复发或转移可能性的ER+结果的雌激素受体(ER)。如美国专利5693465(也结合在本说明书中用于参考)所述，其它的标记如由雌激素调节基因序列pLIV1产生的蛋白质(或多肽)，也可以用于这里。在这样的一个方法中，从被治疗的病人中周期性采血，然后对其进行酶免疫测定，测定一种或多种血清标记。当标记的浓度提示肿瘤复发或治疗失败时，取得可进行基因表达分析的样本源。对于存在有疑似的肿块部位，可以用细针抽吸采样，然后用上述方法对从肿块采集的细胞进行基因表达模式分析。可选择地，可以从与先前肿瘤切除的组织相邻的区域采集组织样本。当其它测试结果不明确时，这种方法是特别有用的。
本发明的制品包括可用于治疗，诊断，预测疾病和其它评估疾病中的基因表达模式的代表物。这些模式代表物还原为一种可被机器自动读取的介质，如计算机可读介质(磁性的，光学的及类似的)。所述制品也可以包括在这种介质中用于评估基因表达模式的指令。例如，制品可以包括CD ROM，其具有比较上述基因文库中的基因表达模式的计算机指令。制品也可以包括基因表达模式的数字记录，以便可以与病人样本的基因表达数据进行比较。可选择地，模式可以不同的表示格式记录。图形记录就是这样一种格式。上面提到的Partek公司的“DISCOVERY”和“INFER”软件中整合的簇类算法，能最好地协助这些数据的形象化。
根据本发明制造的不同类型的制品，是用于揭示基因表达模式的介质或格式化的检测。这些可以包括，例如微阵列，其中序列互补物或探针固定于矩阵上，它与指示感兴趣基因的序列结合产生一种确定其存在的可读判定。可选择地，根据本发明的制品可被制作成试剂盒的形式，用于进行杂交、扩增和产生指示用于检测乳癌的感兴趣的基因表达水平的信号。
根据本发明制备的试剂盒，包括确定基因表达模式的格式化检测。这些可以包括进行检测所需的所有的或部分的物质，如试剂和指令。
本发明进一步地通过下面的非限制性实施例进行说明。
实施例根据本发明进行分析的基因典型地与编码用于蛋白质或多肽的生产的全长核酸序列相关。本领域的普通技术人员将会认识到，全长序列的确认从分析的角度来说不是必需的。也就是，可以根据熟知的为评估相应基因的基因表达设计探针的原理来选择部分序列或ESTs。
实施例1样本处理和LCM收集接受乳癌外科手术病人的新鲜冷冻组织样本。使用的样本来自149个处于第I和II阶段的病人(阶段是根据标准的临床诊断和病理学确定的)。病人的临床结果是已知的。其中，74个病人已经超过7年没有患病了，同时75个病人在4年内存在远距离转移。103个病人呈淋巴结阴性，而46个病人呈淋巴结阳性。
获得的组织在20-30分钟内置于液氮中快速冷冻，然后在-80℃下储存。为了进行激光捕捉，将样本切片(6μm)，并将一个切片固定于载玻片上，另一个切片固定于已被固定于载玻片(Micro Slides Colorfrost，VWR Scientific，Media，PA)上的膜(P.A.L.M.)上。固定于玻璃载片上的切片随后在冷的丙酮中固定，并用Mayer's苏木精(Sigma，St.Louis，MO)染色。病理学家对样本进行分析从而进行诊断和定级。根据相应的外科病理学和验证肿瘤阶段的临床报告来评价其临床阶段。随后在100％乙醇中把固定于膜上的切片固定5分钟，在曙红/100％乙醇(100μg曙红溶于100ml脱水乙醇)中负染1分钟，快速在100％乙醇中浸泡一次以除去未结合的染料，并空气中干燥10分钟。
在LCM中使用前，对膜(LPC-MEMBERANE PEN FOIL 1.35μmNo.8100，P.A.L.M.GmbH Mikrolaser Technologie，Bernried，Germany)和载片进行预处理以除去RNA酶，并且增强组织样品对膜的吸附。简言之，载片用DEP H2O洗涤，膜用RNase AWAY(Molecular Bioproducts，Inc.，San Diego，CA)洗涤并用DEP H2O冲洗。将膜粘附到载玻片上后，将载片于+120℃烘烤8小时，用TI-SAD处理(Diagnostic Products Corporation，Los Angeles，CA，以1∶50溶于DEPH2O，用脱脂棉过滤)，+37℃孵育30分钟。恰在使用前，将10μl等份的RNA酶抑制剂溶液(RNA酶蛋白质抑制剂2500U＝33U/μl N211A，Promega GmbH，Mannheim，Germany，0.5μl溶于400μl冷冻的含有0.15mol NaCl，10mmol TrispH8.0，0.25mmol二硫苏糖醇的溶液)铺展到膜上的固定组织样本的位置。
固定于膜上的组织切片用于LCM。利用PALM自动微光束技术(P.A.L.M.Microlaser Technologie，Carl Zeiss，Inc.，Thornwood，NY)可捕捉约2000个上皮细胞/每样本，并连接到Zeiss Axiovert 135显微镜中(Carl Zeiss Jena GmbH，Jena，Germany)。正常粘膜的外周基质和癌症样本中偶然的干扰基质成分都包括在内。将捕捉到的细胞置于装有100％乙醇的小管中于-80℃保存。
实施例2RNA提取和扩增利用Zymo-Spin柱(Zymo Research，Orange，CA92867)从LCM捕捉的细胞中提取总RNA。将约2ng的总RNA重新悬浮于10μl水并且利用T7 RNA聚合酶进行两轮扩增直至扩增的RNA产量约为50μg。
实施例3-cDNA微阵列杂交和定量用从Affymetrix公司获得并商业化的人的U133a芯片，利用由约23,000个人的cDNA克隆组成的一套cDNA微阵列来检测样本。获得总RNA并用上述的方法制备，将其应用于芯片并根据制造商的使用说明采用AgilentBioAnalyzer进行分析。所有的149个样本均通过质量控制标准，数据用于标记选择。
通过分析103个淋巴结阴性的病人来进行标记选择。采用Cox比例机遇模型鉴定能区别远距离转移和幸存者的基因。芯片强度数据通过Affymetrix公司商业化的5.0版本的MAS软件(“MAS 5.0”)进行分析。首次进行无监督分析，随后进行监督分析。
所述的获得的芯片强度数据，作为商业化的PARTEK 5.1版软件的无监督簇类软件的输入值。这种无监督簇类算法确定了一组具有包括雌激素受体在内的许多基因的显著低表达的22个病人。ER/PR为已知的乳癌不良结果的预后因子，因此这组的22个病人将从随后的用来确定以独立值作为预后指标的附加因子(基因标记)的分析中排除。对剩下的81个病人进行进一步的筛选，从而消除以年龄和肿瘤大小为显著特征的预后指标的潜在影响。因此27个年龄大于55岁或肿瘤大于5cm的病人也被排除。
一个Cox比例机遇模型用于基因选择。训练组31个病人中的每一个都参与了全部31个循环的每个循环，剩下的26个病人用单变量Cox模型回归来评估基因表达与病人存活时间的相关强度。这种相关强度，由相应的估计的标准化的参数估计和从Cox模型回归返回的P值来评价。P值为0.01作为从去一法(leave-one-out)基因选择的每个循环中选择上基因的阀值。然后比较从每个循环中选择的上基因，从而选择在全部31个去一法基因选择循环中出现至少有28次的那些基因。对全部56个基因进行了选择。那些具有Seq.ID No 1到26和Seq.ID No 56的基因表达至少上调了2倍，那些具有Seq.ID No 27到55的基因的基因表达至少下调了2倍。
表1.乳癌预后基因标记



多基因预示变量的构建预测指数定义为56个基因表达值的产物(以10为底的对数值)与其相应的cox模型参数评估值的乘积的总和。来自cox模型的参数评估值测量了当基因表达值升高时的机遇比例。因此，使用这个指数的分数高的病人具有很差的存活结果。这个预测指数用于训练组来获得预测准确度的评估(图1)。
交叉证实和预示变量评估预示变量的表现必须要基于一个独立数据组来确定，因为大多数分类方法在用于构建它们的实例中都很有效。23个病人的测试组用于评估预测的准确性。通过具有90％灵敏度的ROC曲线来确定分类的截止。对于选择的截止，正确预测的测试组中复发和幸存病人的数量总结于(表1)中。根据预测的复发者和幸存者构建了Kaplan-Meier曲线(图2)。
总体预测54个处于第I和II阶段的乳癌病人的基因表达模式确定了在这些病人中差异表达(下调或关闭)的56个基因。这些病人中有36个已经超过7年没有患病了，而27个病人在4年内发生远距离转移。使用56-基因预示变量，27个复发病人中的22个和36个没患病的病人中的27个都被正确地确定了。该结果显示了82％的灵敏度和75％的特异性。阳性预测值为71％，阴性预测值为84％(表2)。根据预测的远距离转移和幸存者构建了Kaplan-Meier曲线(图3)。
以前已出版了一个独立研究报告(Van’Veer et al.，Nature 415，530-535，Vijver et al.，NEJM 347，1999-2009)，其中构建了一个70-基因的预示变量来预测在第I和II阶段淋巴结阴性的乳癌病人的结果。在Van’t Veer等研究的70-基因和本发明的56-基因的预示变量间只有一个基因交迭。
表2.基于使用56-基因预示变量的测试组中的预测准确度

表3.基于采用56-基因预示变量的所有病人的预测准确度

实施例4.更进一步的文库让56个基因的文库接受不同的治疗来进一步更新文库，从而采用较少的基因表达特征进行分析来提供临床上显著的有益效果。
a.在第一个治疗中，采用Spearman等级相关和Pearson相关计算了56个基因的相关系数。使用0.7作为相关截止，建立了一个含有45个调节基因的文库。这些基因示于表4中。
b.在第二个治疗中，使用训练或测试数据组对56个基因进行了t-检验。选择在训练和测试数据中都显示显著p值(＜0.05)的基因构建文库。这样构建了一个含有26个调节基因的库。这些基因如表5所示。
c.然后根据库中基因的已知生物学功能对(b)和表5中的含有26个基因的文库进行评估。选择那些与转移路径有生物学关系的基因。从而建立了一个含有13个调节基因的文库。这些基因如表6所示。
d.从含有56个基因的文库中选择一个显示了最佳的分类效果的含有两个基因的基因对。接着，一个附加基因被加到该文库中，并对其进行测试来确定是否那个特征的加入提高了在两个基因组合的训练组和测试组中全部分类的准确度。可以一直重复该过程直到得不到更进一步的提高为止。建立了一个含有6个调节基因的文库。这些基因如表7所示。
表4-7中所示的每个文库的灵敏度和特异性是根据上述样本的预测的与已知的结果来确定的。这些值如表8-11所示。
表4.45个基因的组


表5.26个基因的组

表6.13个基因的组

表7.6个基因的组

表8.45-基因的预后文库

表9.26-基因的预后文库

表10.13-基因的预后文库

表11.6-基因的预后文库

序列表<110>Wang，Yixin<120>乳癌的预后<130>CDS 5007<160>56<170>PatentIn version 3.1<210>1<211>533<212>DNA<213>人<400>1aaaggcccat taacttaatt taaatgttcc catccttatg aatttactca ctaaggaaaa60ctataagctc agattttaca aacaaaagca acttacaagg tattattgct ggtcctttat120cccttctctt taatgcaatc tcaaaggttt tttggctatt agttttcata attttcttat180gttgcacaca aaaacaagat tcctctctaa aacgtagagg atggggaaaa tgcagatgct240gtttttccaa ctaaaaatgt ttacaaaaga acagactgtc tgaacaaaca aaaaaacccc300accccgttaa gctgggtagg accaatcagg ccttataagt gaaaaaaaag ccttctatcg360agcataatga aacagaacat gtactgcttg tgtttgaacc ttactcttat ttaaccaaaa420atttcccctt tctcataatt ttcctagtat tatgtaaggt tatgcctagt tctagattct480gaaagacctg cattttaatg cttgcacaac ccatttaaaa tctacaaaag ctg 533<210>2<211>1450<212>DNA<213>人<400>2cgtcggcggc cgcggccggg gacggtgtga gagcggtaag atggcggcgg cggcggtggt60
ggagttccag agagcccagt ctctactcag caccgaccgg gaggcctcca tcgacatcct120ccactccatc gtgaagcgtg acattcagga aaacgatgaa gaggcagtgc aagtcaaaga180gcagagcatc ctggaactgg gatctctcct ggcaaagact ggacaagctg cagagcttgg240aggactcctg aagtatgtac gacccttctt gaattccatc agcaaggcta aagcagctcg300cctggtccga tctcttcttg atctgtttct tgatatggaa gcagctacag ggcaggaggt360cgagctgtgt ttagagtcca tcgaatgggc caagtcagag aaaagaactt tcttacgcca420agctttggag gcaagactgg tgtctttgta ctttgatacc aagaggtacc aggaagcatt480gcatttgggt tctcagctgc tgcgggagtt gaaaaagatg gacgacaaag ctcttttggt540ggaagtacag cttttagaaa gcaaaacata ccatgccctg agcaacctgc cgaaagcccg600agctgcctta acttctgctc gaaccacagc aaatgccatc tactgccccc ctaaattgca660ggccaccttg gacatgcagt cgggtattat ccatgcagca gaagagaagg actggaaaac720tgcgtactca tacttctatg aggcatttga gggttatgac tccatcgaca gccccaaggc780catcacatct ctgaagtaca tgttgctgtg caaaatcatg ctcaacaccc cagaagatgt840ccaggctttg gtgagcggga agcttgcact tcggtatgca gggaggcaga cagaagcatt900aaaatgcgtg gctcaggcta gcaagaacag atcactggca gattttgaaa aggctctgac960agattaccgg gcagagctcc gggatgaccc aatcatcagc acacacttgg ccaagttgta1020tgataactta ctagaacaga atctgatccg agtcattgag cctttttcca gagtacagat1080tgaacacata tctagtctca tcaaactctc caaggccgac gtggaaagga aattatcaca1140gatgattctt gacaagaaat ttcatgggat tttggaccag ggggagggtg tcctgattat1200tttcgatgaa cccccagtag ataaaactta cgaagctgct ctggaaacaa ttcagaacat1260gagcaaagta gtggattccc tctacaacaa agccaagaaa ctgacataga gttggatctg1320tagcggtcct ttggagagtg tgtgtggcgg gagagtgaaa ccttggggga aaatgctagg1380
agattctttt ttctttttgt tctacttttc gctcggaaag tttttaaatc ctcatttggt1440gcatctgtat 1450<210>3<211>1633<212>DNA<213>人<400>3ctcaagatga gtaaaaagcc cccaaatcgc cctggaatca cttttgagat tggtgctcgt60ttggaggcac tggactactt acaaaaatgg tatccatcac gaattgaaaa aattgactat120gaggagggca agatgttggt ccattttgag cgctggagtc atcgttatga tgagtggatt180tactgggata gcaatagatt gcgacccctt gagagaccag cactaagaaa agaagggcta240aaagatgagg aagatttctt tgattttaaa gctggagaag aagttctggc tcgttggaca300gactgtcgct attaccctgc caagattgaa gcaattaaca aagaaggaac atttacagtt360cagttttatg atggagtaat tcgttgttta aaaagaatgc acattaaagc catgcccgag420gatgctaagg ggcaggattg gatagcttta gtcaaagcag ctgctgcagc tgcagccaag480aacaaaacag ggagtaaacc tcgaaccagc gctaacagca ataaagataa ggataaagat540gagagaaagt ggtttaaagt accttcaaag aaggaggaaa cttcaacttg tatagccaca600ccagacgtag agaagaagga agatctgcct acatctagtg aaacatttgg acttcatgta660gagaacgttc caaagatggt ctttccacag ccagagagca cattatcaaa caagaggaaa720aataatcaag gcaactcgtt tcaggcaaag agagctcgac ttaacaagat tactggaaga780gaccagctgt gtattttata gctaatatag aatactggaa ggttgtaact ttattggttt840gttggcatcc aaagctgttg gggttgatgg tgctgaaaaa aaggaagact acaatgaaac900agctccaatg ctggagcagg cgatttcacc taaacctcaa agtcagaaaa aaaatgaagc960
tgacattagc agttctgcca acactcagaa acctgcactg ttatcctcaa ctttgtcttc1020agggaaggct cgcagcaaga aatgcaaaca tgaatctgga gattcttctg ggtgtataaa1080accccctaaa tcaccacttt ccccagaatt aatacaagtc gaggatttga cgcttgtatc1140tcagctttct tcttcagtga taaataaaac tatgcctgat gttgcacatt tgccacttga1200gaagctggga ccctgtctcc ctcttgactt aagtcgtggt tcagaagtta cagcaccggt1260agcctcagat tcctcttacc gtaatgaatg tcccagggca gaaaaagagg atacacagat1320gcttccaaat ccttcttcca aagcaatagc tgatggaaga ggagctccag cagcagcagg1380aatatcgaaa acagaaaaaa aagtgaaatt ggaagacaaa agctcaacag catttggtat1440caggagttgg gatttctcag cactgctaat gaagatcccc tcttatagtc caataagctt1500atcaggactt ccagagtcat gacatgaaca gtttaattga acccatccac tctgggcagg1560taagagaaaa gaaaaagata aggaaagaag agagaagaga gacaaagatc actacagacc1620aaaacagaag aag 1633<210>4<211>2666<212>DNA<213>人<400>4ggcacgaggg tcacctggga agagtctgca gagcctttgc ccgccagcgc cttcgctctt60tggctccctg agttaatccg gttgtttgcg atcgccgcgg ccggggctgc gaaccgaagg120gctcgctccg cgccgcctgg gtctctacct catccgtagg tgtggccctg atggtgtggc180aggctctgga ctcctaaagc tctggagcga atttaagatt ttattcatgt gcatggcata240gaagatgaat tcttccactt ccaccatgag tgaagagcct gacgctctat cggtagttaa300ccagttacgg gatctagcag cagatccgtt aaacagaaga gccatcgtcc aggatcaggg360atgtctgcct ggccttattt tatttatgga ccatcccaac cctccagtcg tccactccgc420
tttgcttgct cttcgatact tggcagaatg ccgtgcaaac agagaaaaga tgaaaggaga480actgggtatg atgttgagct tacaaaatgt tatacagaaa actacaactc caggagaaac540aaaacttctg gcctctgaaa tctatgacat tcttcagtcc tccaatatgg cagatggtga600tagttttaat gagatgaatt cacgtcgaag gaaagctcaa ttttttctgg gaactacaaa660caaacgtgcc aaaacagtgg ttttgcatat agatggcctt gatgatacgt ctcggagaaa720tctatgtgaa gaggctttgt taaaaattaa aggtgttatt agctttactt ttcaaatggc780tgttcaaagg tgtgtggtgc gaatccgttc agatttgaaa gctgaggctt tggcatcagc840aatagcatca accaaggtta tgaaagctca gcaagttgtg aaaagtgaaa gtggagaaga900gatgttggtc ccattccaag atactcctgt ggaagttgaa cagaacacag agctacctga960ctacctgcct gaggatgaga gtcccacaaa ggaacaggac aaagcggtgt cccgggtcgg1020ctcacaccca gaaggtggag ctagctggct tagcacagct gcaaactttt tatccagatc1080attttattgg tgacttcact tttgggctca aggactgtgt gaaccaacaa ggggccagtt1140ttccattgtt gtggtgaact gtcaagtgca atttgcaata agttatcatg aaaagttttt1200agattacacg atcgcatatg ctgcatttca cattttattg gacattttac cccactgagt1260ggtaaaaagg acagaggcta cagatggagt tgctttgttt atgaaagtat tttggtttgt1320tttctttcat ttaattgcct catatttaaa aaccatgggt ccactgttaa aaccacatgt1380gtatgtgcag ctttacattt tattttacgt gaagcatgtg attaggaaaa ctcattttct1440tttcaagcct caggacctac ctgaagagaa gttttcttgt agctcaagtt gtgcatgaat1500tactgaatat tttactgtgc ttttcttcat gaagggtaca tgctttgtac tcttcactga1560aagctgaaaa catttcttgt taccctcttt tgtgcctttt tattttgcca accgtgttta1620tagaaaggac attactaatg acattttgca gattaaaaac attcatttga acacagtagt1680cccctagaaa aacaactcta caaaaatttt gcagccttat tcattataat tttgataaaa1740
ttaacacaaa atcagtcaag aaggaaacat gtatattagt gaagtgtttt tggagactgt1800ttgaatgtga ccaaatgtgg ttctagttga cttcttttca ctttggctta tatcaattct1860tgagagttaa tgtgatcatg atattgcaaa caactataaa tggtctctag gccttacttt1920gtgattatac gttatctccg gctagaaaaa aataatggta gtaaagaaac tgacaaactg1980aaaataagaa aacaaaaatc aaatgcctat aataccataa tgccagtttg gtatagagtc2040caactttaaa acatgaattg ctcgacagag ttctattcag taggtgtttc tttgtattgt2100cttttgtgaa tttattatga aaatgctgcg ttgtgttgaa tgaaaaagac ccaaattact2160gcttatgaag aaataaagcc agcattgatc acttaatcct gtttctcatg tccagccaga2220aaaaagaact tcagtgaagg taagataaat aaatacatac acatatgttt ttttggtaga2280taagtgctaa ttacatatat gtaatgcttt attaaatttc tgaaatattt ggtaactaaa2340attttctttt tggaaattaa taaatccaga tacatattaa tgttgatatg agtaaaaaca2400aataggaaga aattgaaatt tcttttcatc aacatgtaga gctgctattt tactatttgg2460agaatatgat gtgaaaattg gacctcaaag ggtttccttg tgttttcatt gtaaaatacc2520atcatcagtg agagtcttga gttcactaac attgtcacct tctggagaga gagttaatgg2580ggggcattga ggatgatatt tttttacatg tgtttggttt ctgattcaag tgacacgcac2640aaactgaaaa aaaaaaaaaa aaaaaa 2666<210>5<211>2445<212>DNA<213>人<400>5tcctgtgcgt ccccaggtca ccgctcgccc tagttcccag gctttggcct ccggtgggcg60agaatcgcgg agcctgcggg gctgggcgcc gaagagccgg gccggcaccc aagcgggcgc120
ggggctgtgc gggccaggcg gaggctcaag cggggatccc cgagcacgac ccccggagcc180gacggcgctg gggcccaagg ggccggccgg gcggtgacga cggcggaggc gaaggggcgg240cgggacccgg gcccggcccg tgtgcgtcct cgacggcccg gccccggctc cgcaggacgg300tgagccccag ggagacggat ctgggctccg ggagggacgc cccgtctgga tttgtcccgt360aggcccggcc cgggcccctc tggagcagaa cggccttggt gaggtggaca ggaagggacc420tcgcgagcag acgcgcgccc gcgacagcaa tcccgccccg gcctgtcggg agcggtgggg480cagaggctgc ggagccccag gaggatctgc ctccgctttc acagtcctcc agatttttcc540aagagcagca gaaaatgaat aaatccctgg ggccagtgtc attcaaggac gtggctgtgg600acttcaccca ggaggaatgg cagcagctgg atcctgagca gaagataact tacagggatg660tgatgctgga gaactacagc aatctagttt ctgtggggta tcacattatc aaaccggatg720ttatcagcaa gttggagcaa ggagaagagc catggatagt agaaggagaa ttcctacttc780agagctatcc agatgaagtc tggcaaactg atgacctaat agagagaatc caggaagagg840aaaataaacc ttcaaggcaa actgtgttca ttgagaccct gattgaagag agaggtaatg900ttcctggtaa aacttttgat gtagaaacga accctgttcc ttcaagaaaa atagcctata960aaaatagcct ctgtgactca tgtgaaaagt gtttaacgtc tgtttcagaa tatattagta1020gtgatggaag ctatgcaaga atgaaagctg atgaatgtag tggatgtggg aaatcactcc1080tccatattaa gcttgagaaa actcatccag gagatcaagc ttatgaattt aatcaaaatg1140gggaacctta tactctaaat gaagaaagtc tttatcagaa aattcgtatt ttggagaaac1200cttttgaata tattgaatgc cagaaagcct tccaaaagga cactgttttt gttaatcaca1260tggaagaaaa gccctataag tggaatggat ctgaaatagc ctttctccag atgtcggacc1320tcactgtaca tcagacatct catatggaaa tgaagcccta tgaatgcagt gaatgtggga1380aatccttctg taaaaagtca aaatttatta tacatcagag gactcacaca ggagagaaac1440
cttacgaatg taatcagtgt gggaaatcct tctgccagaa gggaaccctt actgtgcatc1500agagaacaca cacaggggag aagccctatg aatgtaatga atgtgggaag aacttttacc1560agaagttaca cctcattcag catcagagaa ctcactcagg agagaagccc tatgaatgta1620gttattgtgg aaaatccttt tgccagaaga cacacctcac acaacatcag agaacacatt1680caggagagag accttatgtt tgtcatgact gtgggaaaac cttctcgcag aagtcagcac1740ttaatgacca tcagaaaatt cacacaggtg tgaaactcta caagtgtagt gaatgtggga1800aatgcttctg ccgcaagtct actctcacga cccacctgag gacccacaca ggagagaaac1860cgtatgaatg taatgagtgt ggaaaattct tctctcggtt gtcatatctc actgtacatt1920atagaactca ttcaggagag aaaccctatg agtgtactga atgtggaaaa aaattctacc1980acaaatcagc attcaacagc catcagagaa ttcataggag aggcaatatg aatgtaatag2040atgtgggaag gcttctctga agtcagacct cattttatat cagagaaccc tttcagtata2100gtgaatcaga aactcctgcc tgaagtcaaa caccttgtac atcagagagt tcacacaggt2160tagtgtggac atccccttgt gtgttggact cataatctga agactcacag aatggaaacc2220atgattataa caagaccaca tggtataaca atactagact atagacaagt aaaaatttat2280aaatattaag aatgtatata catgtcacca tggattggaa ctgttttgca tatcagggaa2340atcatagcca aggggaaatc tatcagtata aggaatgtgg aagacataat cctttggaaa2400ctgttaatac taaaagatat gtttctgata caatagcaaa cttga2445<210>6<211>701<212>DNA<213>人<400>6taacggtccc catcttcttg gatcgcttaa cagctggccg gcggttcaca aagtgagtct60gctgtgctgt gtgacctgtg cgcggtctgt ggccggacct aaagatagac cgcaatggct120
gaaaatggtg ataatgaaaa gatggctgcc ctggaggcca aaaatctgtc atcaaattga180gtattatttg gcgacttcaa tttgccacgg gacaagtttc taaaggaaca gataaaactg240gatgaaggct gggtaccttt ggagataatg ataaaattca acaggttgaa ccgtctaaca300acagacttta atgtaattgt ggaagcattg agcaaatcca aggcagaact catggaaatc360agtgaagata aaactaaaat cagaaggtct ccaagcaaac ccctacctga agtgactgat420gagtataaaa atgatgtaaa aaacagatct gttatattaa aggcttccca actgatgcaa480ctcttgatga cataaaagaa tggttagaag ataaaggtca agtactaaat attcagatga540gaagaacatt gcataaagca tttaagggat caatttttgt agtgttgata gcattgaatc600tgtaagaaat ttgtagagac ccctggcaga aagtacaaga aacagacctt gctattactt660tcaaggacga ttactttgcc aaaaaaaatt gacgatgaaa a701<210>7<211>3364<212>DNA<213>人<400>7gattgttgcc gtgcgctgga gccgagtttc gctctgctgc ccaggctgga gtacagtgat60gtgatctcct gacgtcaagt gatccattcg cctcggcctc ccaaagttct gggattacaa120gtaatacaaa atacagttaa taaaatgtca acctcctgga gtgatcggtt acagaatgca180gcagatatgc ctgctaacat ggataagcat gccctgaaaa agtatcgtcg agaagcctat240catcgggtgt ttgtgaaccg aagtttagca atggaaaaga taaagtgttt tggttttgat300atggattata cccttgctgt gtacaagtcc ccagagtatg agtcccttgg ttttgagctt360actgtggaga gattagtttc tattggctat ccccaggagt tgctcagctt tgcttatgat420tctacattcc ctaccagggg acttgtcttt gacacactgt atggaaatct tttgaaagtc480
gatgcctatg gaaacctctt ggtctgtgca catggattta actttataag gggaccagaa540actagagaac agtatccaaa taaatttatc cagcgagatg atactgaaag attttacatt600ctgaacacac tattcaacct accagagacc tacctgttgg cctgcctagt agattttttt660actaattgtc ccagatatac cagttgtgaa acaggattta aagatgggga cctcttcatg720tcctaccgga gtatgttcca ggatgtaaga gatgctgttg actgggttca ttacaagggc780tcccttaagg aaaagacagt tgaaaatctt gagaagtatg tagtcaaaga tggaaaactg840cctttgcttc tgagccggat gaaggaagta gggaaagtat ttcttgctac caacagtgac900tataaatata cagataaaat tatgacttac ctgtttgact tcccacatgg ccccaagcct960gggagctccc atcgaccatg gcagtcctac tttgacttga tcttggtgga tgcacggaaa1020ccactctttt ttggagaagg cacagtactg cgtcaggtgg atactaaaac tggcaagctg1080aaaattggta cctacacagg gcccctacag catggtatcg tctactcagg aggttcttct1140gatacgatct gtgacctgtt gggagccaag ggaaaagaca ttttgtatat tggagatcac1200atttttgggg acattttaaa atcaaagaaa cggcaagggt ggcgaacttt tttggtgatt1260cctgaactcg cacaggagct acatgtctgg actgacaaga gttcactttt cgaagaactt1320cagagcttgg atattttctt ggctgaactc tacaagcatc ttgacagcag tagcaatgag1380cgtccagaca tcagttccat ccagagacgt attaagaaag taactcatga catggacatg1440tgctatggga tgatgggaag cctgtttcgc agtggctccc ggcagaccct ttttgccagt1500caagtgatgc gttatgctga cctctatgca gcatctttca tcaacctgct gtattaccct1560ttcagctacc tcttcagggc tgcccatgtc ttgatgcctc atgaatcaac ggtggagcac1620acacacgtag atatcaatga gatggagtct cctcttgcca cccggaaccg cacatcagtg1680gatttcaaag acactgacta caagcggcac cagctgacac ggtcaattag tgagattaaa1740cctcccaacc tcttcccact ggccccccag gaaattacac actgccatga cgaagatgat1800
gatgaagagg aggaggagga ggaagaataa ggaggaaaac caaaacccca agcacccatt1860aaacaagtcc tggcaggact cacaggaaca aacgaggtcc ctgttagggt tctactcggg1920ggagggaggg ggctccatga aaggtacgtc tgaaaagttt ctgaagattt tattatcata1980gatacttgtt ttggttttgt gtatctgtac tctctgcaga tggtccaaaa ttgtaatgga2040gtctgtatta gaagaaaata agggtaaaat caggctgaac tgcatgtata tggctccact2100gtggcttgtg acacttttaa aatcatccgt atgtcagtgt atctggatac acgaggaaaa2160ggaaagagtc tcagagtgga acaaagagtg ggaagaggtg atctgtaatg ttacaaattg2220tgctattact ccaaggtcca acttttccag tgcattacat ggtattgtat atcagtggag2280aaatgtatta tttccatgat caaatgtagt ctctgttaag gtcaagtttt cttttataag2340cctttaattc atcctcagtg actctggcaa ggctgcttct ctatcactgg ctttgcacag2400aagtatgctc tacttgcgtt gctttagggc aggattctat tttgagggaa aagacagtat2460ccttattacc ttttgtttgt ttaatagcac aaatgcttat ttgttatcca aaaacaacct2520ccttcttatc tgtgataaat ctatagaaag aatttagctg caagtggaca aaggaacaag2580cccccagaaa agaaagggaa gaactgcctt cttatactac agaacatgca ttagtgtggg2640ctatatagct gtggctcatg ctacccaatt ccagatttct ttgtcctcta agagttgatt2700gctgtatatt aaaattgaac atcagaggat gggaagaggg ctctgtaagc cagaacctta2760ctaaagtaga gggcacaatc agtgtgaata aattcacttc agaatctcaa gtcaaggcca2820ggcacggcgg ctcacgcctg taatcccagc actttgggag gccgagacag gcggatcacc2880tgaggtcggg agttcgagac cagccttacc aacatggaga aaccccatct ctactaaaaa2940tacaaaatta cctgggcgtg gtggtgcatg cctgtaatcc catcatctac tcaggaggct3000gaggcaggag aattgcttga acccaggagg cggaggttgc agtgagccag gattgtgcca3060ttgcactcca gcctgggcaa caagaacaaa actccatctc aaaaaataaa aatcccaatc3120
ccaagtcgaa atcacctctt gttttaaaca agaatgaatc attactgtgt atgttagggt3180attaaaactg tttcaccagt acagtgaaag ttgtttcaac attttaaaca aacagtggtt3240atagactctt tctttaacca ttgtatattt tcttccattc ttgtcattgg tcaatagggg3300agggtagatt agctgctcca gaattcaata aagtgtaata tttctaaaaa aaaaaaaaaa3360aaaa 3364<210>8<211>3825<212>DNA<213>人<400>8aagacaactt gagctgaaag cgaaaaacta tgctgaccag attagcagac ttgaagaaag60agaagcagaa ctgaagaagg aatataatgc attacatcaa agacacactg agatgatcca120taattatatg gaacatttag aaagaacaaa acttcatcag ctctcaggga gtgatcaact180agaatccaca gctcatagta gaattagaaa agaacgccct atatcattag gaattttccc240attacctgct ggagatggat tgcttacacc tgatgctcag aaaggaggag agacccctgg300atctgagcaa tggaaatttc aggaattaag tcaaccacgt tctcatacca gcctgaagga360tgagctttct gatgttagcc aaggcggatc taaagctacc actccagcat caacagctaa420ttcagatgtg gcaacaattc ctactgatac tcccttaaag gaagaaaacg aaggatttgt480gaaggttaca gatgcgccaa ataaatcaga gataagcaaa cacattgaag tacaggtagc540ccaggaaact agaaatgtat ctactggctc tgctgaaaat gaagaaaagt cagaagttca600agcaatcatc gaatctactc ctgagctgga tatggacaaa gatctcagtg gatataaagg660ttcaagcact cccaccaaag gcatagagaa caaagctttt gatcgcaata cagaatctct720ctttgaagaa ctgtcttcag ctggctcagg cctaatagga gatgtggatg aaggagcaga780tttactagga atgggtcggg aagttgagaa tcttatatta gaaaatacac aactgttgga840
aaccaaaaat gctttgaaca tagtgaagaa tgatttgata gcaaaagtgg atgaactgac900ctgtgagaaa gatgtgctgc aaggggaatt ggaggctgtg aagcaagcca aactgaaact960agaggaaaag aacagagaat tggaggaaga gcttaggaaa gctcgggcag aagctgaaga1020tgcaaggcaa aaagcaaaag atgacgatga tagtgatatt cccacagccc agaggaaacg1080gtttactaga gtagaaatgg cccgtgttct catggagcga aaccagtata aagagagatt1140gatggagctt caggaagctg ttcgatggac agagatgatt cgggcatcac gagaaaatcc1200agccatgcag gaaaaaaaaa ggtcaagcat ttggcagttt ttcagccgac ttttcagctc1260ctcaagtaac acgactaaga agcctgaacc acctgttaat ctgaagtaca atgcacccac1320gtctcatgtt actccgtccg tcaagaaaag aagcagcacc ttatctcagc tccctgggga1380taagtccaaa gcctttgatt tccttagtga agaaactgaa gctagtttag cctcacgcag1440agaacaaaag agagagcagt atcgtcaggt aaaagcacat gttcagaagg aagacggtag1500agtgcaggct tttggctgga gtctgcctca gaagtacaaa caggtaacca atggtcaagg1560tgaaaataag atgaaaaatt tacctgtgcc tgtctatctc agacctctgg atgaaaaaga1620tacatcaatg aagctgtggt gtgctgttgg agtcaattta tctggtggga agaccagaga1680tggtggttct gttgttggag caagtgtatt ttacaaggat gttgctggtt tggatacaga1740aggcagtaaa cagcgaagtg cctctcagag tagtttagat aagttagatc aggaacttaa1800ggaacagcag aaggagttaa aaaatcaaga agaattatcc agtctagttt ggatctgtac1860cagcactcat tcggctacaa aagttcttat tattgatgct gttcaacctg gcaacatcct1920agacagtttc actgtttgca actctcatgt tctgtgcatt gcaagtgtgc caggtgcacg1980agaaacagac taccctgcag gagaagatct ttcagaatct ggtcaggtag acaaagcatc2040tttatgtgga agtatgacaa gcaacagctc agcagagaca gacagcctgt taggaggcat2100cacagtggtt ggttgttctg cagaaggtgt gacgggagct gccacttccc ctagtacaaa2160
tggtgcttct ccagtgatgg ataaaccacc agaaatggaa gcagaaaata gtgaggttga2220tgaaaatgtt ccaacagcag aagaagcaac tgaagctaca gaagggaatg cggggtcagc2280tgaagacaca gtggacatct cccaaactgg cgtctacaca gagcatgtct ttacagatcc2340tttgggagtt cagatcccag aagacctctc cccagtgtat cagtcgagca atgactcaga2400tgcatataaa gatcaaatat cagtactgcc aaatgaacaa gacttggtga gagaagaagc2460ccagaaaatg agtagtcttt taccaactat gtggcttgga gctcaaaatg gctgtttgta2520tgtccattca tctgtagccc agtggaggaa atgtctccat tccattaaac ttaaagattc2580gattctcagt attgtacacg tgaagggaat cgtgttagta gccctggctg acggcaccct2640tgcaatcttt cacagaggag tggatgggca gtgggatttg tcaaactatc acctcttaga2700ccttggacgg cctcatcatt ccatccgttg catgactgtg gtacatgaca aagtctggtg2760tggctatagg aacaaaatct atgtggtgca gccaaaggcc atgaaaatag agaaatcttt2820tgatgcacat cccaggaagg agagccaagt gcgacagctt gcgtgggtgg gggatggcgt2880gtgggtctcc attcgcttgg attctacgct ccgtctctat catgcacaca cttatcaaca2940tctacaggat gtggacattg agccttatgt aagcaaaatg ttaggtactg gaaaactggg3000cttctctttt gtgagaatta cagctcttat ggtgtcttgt aatcgtttgt gggtggggac3060aggaaatggt gtcattatct ccatcccatt gacagaaaca aataaaacct caggtgtacc3120aggaaatcgt cctggaagtg taatccgtgt atatggtgat gaaaacagtg ataaagtgac3180tccagggaca tttataccct attgttcaat ggcacatgca cagctttgct tccatgggca3240ccgggatgct gtgaaattct ttgtggcagt cccaggtcaa gtcatcagcc cacaaagtag3300cagtagtggc acggatctga cgggtgacaa agcagggcca tctgcacagg agcctggtag3360tcagacgccc ttgaagtcta tgcttgtcat cagtggagga gagggctaca tcgacttccg3420aatgggtgat gaaggtggag aatcagaact tcttggagag gatcttccac ttgaaccttc3480
tgtcaccaaa gcagaaagga gtcacttgat agtgtggcaa gtgatgtatg gcaatgagtg3540agcccatggg aaacaggtgg agatggggaa gccgtctctt ctgcatggtt tattttccct3600ctatcctttt atttaatgct cttttgtgag ataagtttca ccacataatg tgtgagcatt3660ttttcctgtt aactttatat tacaaaatcc gttctaccat aacaatacag aggaactagc3720tgtgttactg caccagtgtt ataggtaact tcagtatatt atgaacaaat caaagaatgt3780ttacttcctg caaactggtg aattatagaa agcaatccag atgtg3825<210>9<211>471<212>DNA<213>人<220>
<221>混杂的特征<222>(468)..(468)<223>任何一种碱基<400>9tttggtttgt ttgtttttta aagacagggt cttgctctgt cacctaggct ggagtgcagt60ggcatgatct tggctcactg caacctccac ctcctggact caagcaatcc tcccacctca120gcctcccaag tagctgggac taaaagtgcg gacccggcta atttttgtat tttttgtaga180gatggggtct ccctatgttg cccaggctgg tctcgaatgc ccgggctcaa gtgatctgcc240cgccttggct tcccaaagtg ctgcgattac aggcatgagg cactgtgcct ggccttcgtg300gaaatcctaa aaagcaacac cacatagtgc tgggctgtat ccaggccagt gggcaccttc360cgtgctggta atgaacagcc acaaaacttc tggaaaacca catggaagtt tctattttat420gtgaaatgtc gaactcacac accacttgcc cagtggtcct gaggagtnca c 471<210>10
<211>565<212>DNA<213>人<220>
<221>混杂的特征<222>(476)..(476)<223>任何一种碱基<220>
<221>混杂的特征<222>(482)..(482)<223>任何一种碱基<400>10ggcaccatac tgttttattt aaacctgcaa acaatataaa gaggtaagga cttctgacgc60caaaccatgc aagtaataac aaaggaacag agaaaaatat taataacaaa aagaaaatca120ttaaaaataa aaaaacaaag tacttcacat ttcacagcag tgctttggca gtactggcaa180gcatttctgg tcaactgctt ccaacagcag gaatatgaag aaacccccag atcttagcaa240aagtgtaaca acattttctc cctgacagct tacattccaa gtcattccat accataccgc300tccactccac agttttataa acctgatctt aagatgtaac taggtactat gtgtgctcac360aataaaaact aactaaaaac aaatcagagg gtagcagaca agtaaacaaa gtttccagta420aggcatcagg agatcactgc tggtgggccc ctcactttac cagcttaaag aagttntgat480tnttatttct cagcaaactc aatattcaga agctttacca gcagactcaa gtcaaaggtt540ttaaatacag tttacctcat ttttt 565<210>11<211>3615<212>DNA<213>人<400>11
ggactgtgtg tgtctggctg tagcagacgc gaggcggcga cgaggcgccg gggacccgcg60cgaggggcgg ccgggaggcg gcggcggcgg ccgccagaag tagcagcagg accggcggcg120gcgacggcag ccctgaaatg cattttcctc tccagcggcc atgttaacca ggaaaccttc180ggccgccgct cccgccgcct acccgaccgg ccgaggtggg gacagcgccg ttcgtcagct240tcaggcttcc ccggggctcg gtgcagggcc cacccggagc ggagtgggga ctggcccgcc300ctcccccatc gccctgccgc ctctccgggc cagcaacgct gccgccgcag cccacacgat360tggcggcagt aagcacacaa tgaatgatca cctgcatgtc ggcagccacg ctcacggaca420gatccaggtt caacagttgt ttgaggataa cagtaacaag cggacagtgc tcacgacaca480accaaatggg cttacaacag tgggcaaaac gggcttgcca gtggtgccag agcggcagct540ggacagcatt catagacggc aggggagctc cacctctcta aagtccatgg aaggcatggg600gaaggtgaaa gccaccccca tgacacctga acaagcaatg aagcaataca tgcaaaaact660cacagccttc gaacaccatg agattttcag ctaccctgaa atatatttct tgggtctaaa720tgctaagaag cgccagggca tgacaggtgg gcccaacaat ggtggctatg atgatgacca780gggatcatat gtgcaggtgc cccacgatca cgtggcttac aggtatgagg tcctcaaggt840cattgggaag gggagctttg ggcaggtggt caaggcctac gatcacaaag tccaccagca900cgtggcccta aagatggtgc ggaatgagaa gcgcttccac cggcaagcag cggaggagat960ccgaatcctg gaacacctgc ggaagcagga caaggataac acaatgaatg tcatccatat1020gctggagaat ttcaccttcc gcaaccacat ctgcatgacg tttgagctgc tgagcatgaa1080cctctatgag ctcatcaaga agaataaatt ccagggcttc agtctgcctt tggttcgcaa1140gtttgcccac tcgattctgc agtgcttgga tgctttgcac aaaaacagaa taattcactg1200tgaccttaag cccgagaaca ttttgttaaa gcagcagggt agaagcggta ttaaagtaat1260tgattttggc tccagttgtt acgagcatca gcgtgtctac acgtacatcc agtcgcgttt1320
ttaccgggct ccagaagtga tccttggggc caggtatggc atgcccattg atatgtggag1380cctgggctgc attttagcag agctcctgac gggttacccc ctcttgcctg gggaagatga1440aggggaccag ctggcctgta tgattgaact gttgggcatg ccctcacaga aactgctgga1500tgcatccaaa cgagccaaaa attttgtgag ctccaagggt tatccccgtt actgcactgt1560cacgactctc tcagatggct ctgtggtcct aaacggaggc cgttcccgga gggggaaact1620gaggggccca ccggagagca gagagtgggg gaacgcgctg aaggggtgtg atgatcccct1680tttccttgac ttcttaaaac agtgtttaga gtgggatcct gcagtgcgca tgaccccagg1740ccaggctttg cggcacccct ggctgaggag gcggttgcca aagcctccca ccggggagaa1800aacgtcagtg aaaaggataa ctgagagcac cggtgctatc acatctatat ccaagttacc1860tccaccttct agctcagctt ccaaactgag gactaatttg gcgcagatga cagatgccaa1920tgggaatatt cagcagagga cagtgttgcc aaaacttgtt agctgagctc acgtcccctg1980atgctggtaa cctgaaagat acgacattgc tgagccttac tgggttgaaa aggagtagct2040cagacctgtt tttatttgct caataactct actcatttgt atcttttcag cacttaattt2100taatgtaaga aagttgttca ttttgttttt ataaaataca tgaggacaat gctttaagtt2160tttatacttt cagaaacttt ttgtgttcta aaagtacaat gagccttact gtatttagtg2220tggcagaata ataacatcag tggcaggcca ctgattactt catgactgcc acgcatttac2280agattggtgt caaagacatt cactatgttt ttatggttca tgttatatcc tccccagggt2340gacagcccct taaggccctc cttttccctc catgctccag gtccatgcac aggtgtagca2400tgtcctgctt ccgtttttca taaattaatc tgggtgttgg gggtagtggg aggagaacgg2460tcagaatcaa agtgacattc taagaaaaac tgtaccttag agattttcct ctagtgctca2520aacaaataca aaataagatc cccaaggttt aaactgccca gttagcattc tgacattcta2580aaagccggca aagcagcttt tagtggataa atgggaatgg aaacgtgtgt gttcctccaa2640
attttctagt atgatcggtg agctgttttg taaagaagcc tcatattaca gagttgcttt2700tgcacctaaa tttagaattg tattccatga actgttcctc ccttttctct gcttttctcc2760tctctgttcc tcttttaata ccacacgtct gttgcttgca tttagtttgt cttcttcctt2820cagctgtgta tcccagactg ttaatacaga aaagagacat ttcagctgtg attatgacca2880ttgtttcata ttccaattaa aaaaagaaca gcagcctagc tacttaaggt ggggatttca2940tagttccaaa gaagatttag cagattagag tgagttcaca cttttcaggt gccactgtaa3000ggttctctca gcctgggaaa ctatcaactc tttctttaaa aagaaagagg gttgaaaatc3060ctctggacga acagaagtca ctttggctgt tcagtaaggc caatgttaac aacacgttta3120gaggaggaaa agttcaacct caagttaaat ggtttgactt attcttcgta tcattagaag3180aaccccagag atagcattcc tctattttat tttactttct tttggattgc actgattgtt3240tttgtgggaa tgacacttta tctggcaaag taactgagag tttggtaaaa gaatattttc3300ttctctgaat aataattatt ttcacagtga aaatttcagt attttatcac taatgtatga3360gcaatgatct atatcaattt caaggcacgt gaaaaaaatt ttttagtatg tgcaatttaa3420tatagaaaga tttctgcctg tttggacaat aggttttggg tagtacagat taggataagt3480aagcttatat atgcacagag attattgtat tacctgtaaa ttgatttaca agtacttaaa3540agcgtggtcc ccagtgaggc caagaaagtt tccggttaag ttctttaata ataatcctac3600agtttatctt aagaa 3615<210>12<211>4908<212>DNA<213>人<400>12acctgcgtgc agtcggtcct ccaggccacg cagcgcccga gagtaccagg gagactccgg60cccctgtcgg cgccaagccc ctccgcccct cacagcgccc aggtccgcgg ccgggccttg120
attttttggc ggggaccgtc atggcgtcgc agccaaattc gtctgcgaag aagaaagagg180agaaggggaa gaacatccag gtggtggtga gatgcagacc atttaatttg gcagagcgga240aagctagcgc ccattcaata gtagaatgtg atcctgtacg aaaagaagtt agtgtacgaa300ctggaggatt ggctgacaag agctcaagga aaacatacac ttttgatatg gtgtttggag360catctactaa acagattgat gtttaccgaa gtgttgtttg tccaattctg gatgaagtta420ttatgggcta taattgcact atctttgcgt atggccaaac tggcactgga aaaactttta480caatggaagg tgaaaggtca cctaatgaag agtatacctg ggaagaggat cccttggctg540gtataattcc acgtaccctt catcaaattt ttgagaaact tactgataat ggtactgaat600tttcagtcaa agtgtctctg ttggagatct ataatgaaga gctttttgat cttcttaatc660catcatctga tgtttctgag agactacaga tgtttgatga tccccgtaac aagagaggag720tgataattaa aggtttagaa gaaattacag tacacaacaa ggatgaagtc tatcaaattt780tagaaaaggg ggcagcaaaa aggacaactg cagctactct gatgaatgca tactctagtc840gttcccactc agttttctct gttacaatac atatgaaaga aactacgatt gatggagaag900agcttgttaa aatcggaaag ttgaacttgg ttgatcttgc aggaagtgaa aacattggcc960gttctggagc tgttgataag agagctcggg aagctggaaa tataaatcaa tccctgttga1020ctttgggaag ggtcattact gcccttgtag aaagaacacc tcatgttcct tatcgagaat1080ctaaactaac tagaatcctc caggattctc ttggagggcg tacaagaaca tctataattg1140caacaatttc tcctgcatct ctcaatcttg aggaaactct gagtacattg gaatatgctc1200atagagcaaa gaacatattg aataagcctg aagtgaatca gaaactcacc aaaaaagctc1260ttattaagga gtatacggag gagatagaac gtttaaaacg agatcttgct gcagcccgtg1320agaaaaatgg agtgtatatt tctgaagaaa attttagagt catgagtgga aaattaactg1380ttcaagaaga gcagattgta gaattgattg aaaaaattgg tgctgttgag gaggagctga1440
atagggttac agagttgttt atggataata aaaatgaact tgaccagtgt aaatctgacc1500tgcaaaataa aacacaagaa cttgaaacca ctcaaaaaca tttgcaagaa actaaattac1560aacttgttaa agaagaatat atcacatcag ctttggaaag tactgaggag aaacttcatg1620atgctgccag caagctgctt aacacagttg aagaaactac aaaagatgta tctggtctcc1680attccaaact ggatcgtaag aaggcagttg accaacacaa tgcagaagct caggatattt1740ttggcaaaaa cctgaatagt ctgtttaata atatggaaga attaattaag gatggcagct1800caaagcaaaa ggccatgcta gaagtacata agaccttatt tggtaatctg ctgtcttcca1860gtgtctctgc attagatacc attactacag tagcacttgg atctctcaca tctattccag1920aaaatgtgtc tactcatgtt tctcagattt ttaatatgat actaaaagaa caatcattag1980cagcagaaag taaaactgta ctacaggaat tgattaatgt actcaagact gatcttctaa2040gttcactgga aatgatttta tccccaactg tggtgtctat actgaaaatc aatagtcaac2100taaagcatat tttcaagact tcattgacag tggccgataa gatagaagat caaaaaaagg2160aactagatgg ctttctcagt atactgtgta acaatctaca tgaactacaa gaaaatacca2220tttgttcctt ggttgagtca caaaagcaat gtggaaacct aactgaagac ctgaagacaa2280taaagcagac ccattcccag gaactttgca agttaatgaa tctttggaca gagagattct2340gtgctttgga ggaaaagtgt gaaaatatac agaaaccact tagtagtgtc caggaaaata2400tacagcagaa atctaaggat atagtcaaca aaatgacttt tcacagtcaa aaattttgtg2460ctgattctga tggcttctca caggaactca gaaattttaa ccaagaaggt acaaaattgg2520ttgaagaatc tgtgaaacac tctgataaac tcaatggcaa cctggaaaaa atatctcaag2580agactgaaca gagatgtgaa tctctgaaca caagaacagt ttatttttct gaacagtggg2640tatcttcctt aaatgaaagg gaacaggaac ttcacaactt attggaggtt gtaagccaat2700gttgtgaggc ttcaagttca gacatcactg agaaatcaga tggacgtaag gcagctcatg2760
agaaacagca taacattttt cttgatcaga tgactattga tgaagataaa ttgatagcac2820aaaatctaga acttaatgaa accataaaaa ttggtttgac taagcttaat tgctttctgg2880aacaggatct gaaactggat atcccaacag gtacgacacc acagaggaaa agttatttat2940acccatcaac actggtaaga actgaaccac gtgaacatct ccttgatcag ctgaaaagga3000aacagcctga gctgttaatg atgctaaact gttcagaaaa caacaaagaa gagacaattc3060cggatgtgga tgtagaagag gcagttctgg ggcagtatac tgaagaacct ctaagtcaag3120agccatctgt agatgctggt gtggattgtt catcaattgg cggggttcca tttttccagc3180ataaaaaatc acatggaaaa gacaaagaaa acagaggcat taacacactg gagaggtcta3240aagtggaaga aactacagag cacttggtta caaagagcag attacctctg cgagcccaga3300tcaaccttta attcacttgg gggttggcaa ttttattttt aaagaaaact taaaaataaa3360acctgaaacc ccagaacttg agccttgtgt atagatttta aaagaatata tatatcagcc3420gggcgcggtg gctcatgcct gtaatcccag cactttggga ggctgaggcg ggtggattgc3480ttgagcccag gagtttgaga ccagcctggc caacgtggca aaacctcgtc tctgttaaaa3540attagccggg cgtggtggca cactcctgta atcccagcta ctggggaggc tgaggcacga3600gaatcacttg aacccaggaa gcggggttgc agtgagccaa aggtacacca ctacactcca3660gcctgggcaa cagagcaaga ctcggtctca aaaacaaaat ttaaaaaaga tataaggcag3720tactgtaaat tcagttgaat tttgatatct acccattttt ctgtcatccc tatagttcac3780tttgtattaa attgggtttc atttgggatt tgcaatgtaa atacgtattt ctagttttca3840tataaagtag ttcttttata acaaatgaaa agtatttttc ttgtatatta ttaagtaatg3900aatatataag aactgtactc ttctcagctt gagcttaaca taggtaaata tcaccaacat3960ctgtccttag aaaggaccat ctcatgtttt ttttcttgct atgacttgtg tattttcttg4020catcctccct agacttccct atttcgcttt ctcctcggct cactttctcc ctttttattt4080
ttcaccaaac catttgtaga gctacaaaac ctatcctttc ttattttcag tagtcagaat4140tttatctaga aatcttttaa caccttttta gtggttattt ctaaaatcac tgtcaacaat4200aaatctaacc ctagttgtat ccctccttta agtatttaaa acttgttgcc ccaaatgtga4260aagcatttaa ttcctttaag aggcctaact cattcaccct gacagagttc acaaaaagcc4320cactttagag tatacattgc tattatggga gaccacccag acatctgact aatggctctg4380tgccacactc caagacctgt gccttttaga gaagctcaca atgatttaag gactgtttga4440aacttccaat tatgtctata atttatattc ttttgtttac atgatgaaac tttttgttgt4500tgcttgtttg tatataatac aatgtgtaca tgtatctttt tctcgattca aatcttaacc4560cttaggactc tggtattttt gatctggcaa ccatatttct ggaagttgag atgtttcagc4620ttgaagaacc aaaacagaag gaatatgtac aaagaataaa ttttctgctc acgatgagtt4680tagtgtgtaa agtttagaga catctgactt tgatagctaa attaaaccaa accctattga4740agaattgaat atatgctact tcaagaaact aaattgatct cgtagaatta tcttaataaa4800ataatggcta taatttctct gcaaaatcag atgtcagcat aagcgatgga taatacctaa4860taaactgccc tcagtaaatc catggttaat aaatgtggtt tctacatt 4908<210>13<211>3302<212>DNA<213>人<400>13ggcacgaggc ggcagtctct tcgcggcgtc caccacttag acgcaagttg ctgaagccgg60ccggggagaa ggtgttgttg ccggagctga gaccgggcgg ccacagtccg cagggatgaa120cctcgagttg ctggagtcct ttgggcagaa ctatccagag gaagctgatg gaactttgga180ttgtatcagc atggctttga cttgcacctt taacaggtgg ggcacactgc ttgcagttgg240
ctgtaatgat ggccgaattg tcatctggga tttcttgaca agaggcattg ctaaaataat300tagtgcacac atccatccag tgtgttcttt atgctggagc cgagatggtc ataaactcgt360gagtgcttcc actgataaca tagtgtcaca gtgggatgtt ctttcaggcg actgtgacca420gaggtttcga ttcccttcac ccatcttaaa agtccaatat catccacgag atcagaacaa480ggttctcgtg tgtcccatga aatctgctcc tgtcatgttg accctttcag attccaaaca540tgttgttctg ccggtggacg atgactccga tttgaacgtt gtggcatctt ttgataggcg600aggggaatat atttatacgg gaaacgcaaa aggcaagatt ttggtcctaa aaacagattc660tcaggatctt gttgcttcct tcagagtgac aactggaaca agcaatacca cagccattaa720gtcaattgag tttgcccgga aggggagttg ctttttaatt aacacggcag atcgaataat780cagagtttat gatggcagag aaatcttaac atgtggaaga gatggagagc ctgaacctat840gcaggaattg caggatttgg tgaataggac cccatggaag aaatgttgtt tctctgggga900tggggaatac atcgtggcag gttctgcccg gcagcatgcc ctgtacatct gggagaagag960cattggcaac ctggtgaaga ttctccatgg gacgagagga gaactcctct tggatgtagc1020ttggcatcct gttcgaccca tcatagcatc catttccagt ggagtggtat ctatctgggc1080acagaatcaa gtagaaaact ggagtgcatt tgcaccagac ttcaaagaat tggatgaaaa1140tgtagaatac gaagaaaggg aatcagggtt tgatattgaa gatgaagata agagtgagcc1200tgagcagaca ggggctgatg ctgcagaaga tgaggaagtg gatgtcacca gcgtggaccc1260tattgctgcc ttctgtagca gtgatgaaga gctggaagat tcaaaggctc tattgtattt1320acccattgcc cctgaggtag aagacccaga agaaaatcct tacggccccc caccggatgc1380agtccaaacc tccttgatgg atgaaggggc tagttcagag aagaagaggc agtcctcagc1440agatgggtcc cagccaccta agaagaaacc caaaacaacc aatatagaac ttcaaggagt1500accaaatgat gaagtccatc cactactggg tgtgaagggg gatggcaaat ccaagaagaa1560
gcaagcaggc cggcctaaag gatcaaaagg taaagagaaa gattctccat ttaaaccgaa1620actctacaaa ggggacagag gtttacctct ggaaggatca gcgaagggta aagtgcaggc1680ggaactcagc cagcccttga cagcaggagg agcaatctca gaactgttat gaagaccttc1740gaagttcttc attctttctc actttgccat catgtggcct ctggacactg tggtcagtca1800tttgaaaatt gactttaatt taaaacaaag gcctgtgctc cacccaggag gtgggaggtg1860aattttatgt ttaaatgaag aagtgaatta tggaagaagg tatacgacct tcccttcctt1920ttcaagcata agtccaaata gactctcagg aatgaagatt tgtgaagaca tcagatagga1980attttggact catttaaact ttgatgctta gttatgttgc tggagaaaag atacttatgt2040tttgctcatc taacttcatt gtacccagcg tcattttgac atgtcatttc ctatctccca2100tttgccttcg gtcctcaatg catgtctttg agtgacttct tatctgaaat tttgctactg2160gtatcctagg aaagcttttg ttggatactc tcattttaaa cttctcctct ccccagatac2220ctcctatatt tccatattgt gtgcaaagga tgggcagaaa agaaagtgct tgaaagattt2280caaattttca gaaagggaac aacgaaggcc ctctcttcct ctcataccac gttttgctca2340agaagctggg ctgtaacaat tcagggtttt cccttgtttt cctctcattg catgtttccc2400tccaatattg gttcattgtc atcaatcatg gtttttgaag atagctagtt ttatccatct2460ccagcaaaga atcatcaata gtttatattg ctttacctgt gctggcttcc agagatggaa2520acaaacccag gtgtctctca acaagctact tttttactgg ggtgggggaa tctatgcaag2580gagtaaagta aaaccatcca gaatcaaagc agcaaccaca tagttcaaat caaagatcaa2640ggtgaatttt ttgtatcact gcctgtggaa atctatcctc atcagtcatt gcatttttcc2700ctgcctatac ctgtgctcct ttttcttact gtgttttcag tcacttcctt tctgtgaaag2760gttgcttagc tttttttttg acatttgttg ttctttatat aaaaataaca gattggatag2820atgtgtacat ttggtgtttg aaattctctg aaaatcccat taggaaacca ggtgtgaaaa2880
gggctcagta gcttctctga gtggcgtttt tagctgactg gaagtgctta atctggatcg2940tctttttttt tttttttttt ttcaatattt taaaaggaga atttaaatac tgtgcttact3000gtgaaatata tcagttggtg agccgggcgt ggtgggtcac gcctgtaatc ccagcacttt3060gggaggccaa ggcgggtgga tcacccgagg tcaggagttc aagaccagcc tggccaacgt3120ggtgaaagcc tgtatctatt aaaagacaaa aattagctgg gcgtggtggt acatgcctgt3180aatcccagct acactggagg ctgagtcagg agaatcactt gaacgtggga ggcagaggtt3240gcagtgagtg gagatcgcac cactgccctc cagcctaggt gacagaatga gactctatct3300ca 3302<210>14<211>1999<212>DNA<213>人<400>14acgcgctctt agaccatggc gacccaggcg aagcgtccac gggtggcggg gcccgtggac60ggcggcgacc tggatcctgt ggcctgcttc ctgagctggt gccggcgggt ggggctggag120ctgagtccca aggtggcggt cagccggcag ggcacggtgg ccggctacgg catggtggcc180cgggagagcg tgcaggccgg agagctgctg ttcgtggtgc cgcgggccgc gctcctgtcg240cagcacacct gctccatcgg cggcctgctg gagcgagagc gagttgcgct gcagggccag300tcgggctggg tgccactgct gctggcgctg ctccacgagc tgcaggcccc ggcctcacgc360tggaggccct actttgcgct ctggcccgag ctgggccgct tggagcaccc gatgttctgg420ccagaggagg agcgccggtg cctgctccag ggcacaggcg tacctgaggc cgtggagaag480gatttggcca acatccgcag cgagtaccag tccatcgtgc tgcccttcat ggaagcccac540cccgatctct tcagcctcag ggttcgctcc ctagaactct accaccagct ggtggccctt600gtgatggcct atagctttca ggtaccactg gaggaagaag aggatgaaaa ggagcccaac660
tcccccgtga tggtgcctgc tgcagacata ctaaaccact tagccaatca caacgccaat720ctagaatact ctgcgaattg tcttcggatg gtagccactc agcccattcc taaaggccat780gagattttca acacttatgg gcaaatggct aactggcaac tgattcatat gtacggtttt840gttgaaccat atcctgacaa cacagatgac acagctgaca ttcagatggt gacagttcgt900gaggcagcat tacagggaac aaaaactgaa gctgaaaggc acctagtgta cgagcgctgg960gatttcctat gcaaactgga gatggtaggg gaagagggag cctttgtgat agggagggag1020gaggtgctga ctgaagagga gctgaccacc acactaaagg tactgtgcat gcctgctgag1080gagttcagag agcttaaaga ccaggatgga gggggagatg ataaaaggga agagggcagc1140ctgacgatca caaatattcc caagctcaaa gcatcgtgga gacagctgct tcaaaacagt1200gttctactga ctttgcagac ctatgccaca gacttaaaaa ctgaccaagg tttactcagt1260aataaggaag tctatgcgaa actcagctgg agggaacagc aagccttaca ggttcgctat1320ggtcagaaga tgatcttaca tcagttgttg gaactgacaa gttagcagtt tccctgttcc1380ctgaaggaac agcaataaga actttattct aagctaatac tcattgatgt ttgaaaaaga1440ggaaaatttg gatctttctt ttgcttacta aacaccaaga ggaaaagtag caaagttggt1500gtgctaggat taactcaggt aagggtgatg tgttttagga ttgagaacag cagacttggg1560aatcactgct aattgttact taaagcatgt tacagctgtt ttgttctcag ttttaaccaa1620agccagtgga catacggtag taataactaa gtcttgttgt gtttcagcat ttaataatag1680actttggagg tagacccctg gtttaaatct aagtctagtt tgaggaagtc acttaacctt1740tattgaaaag actctggatt taataagctg tgtaactggt actcgatagt tacccaaagt1800tcagtctaga tggcacaaac cacctctcag ggaataaacc ctaagacatc actcaaggag1860gacttcaatt atttaatttt gaactgtttt gtcctctctg gccataaaac ttgacagtca1920tgaaaggtaa ggcaaatttt aagtgggtta agtttttaaa tacgtatcta ctcattttct1980
ttaaaaaaaa aaaaaaaaa 1999<210>15<211>1503<212>DNA<213>人<400>15ggggctccac tttctttccc tctccgtttt ggtgggctgg ttggagatga aatccactga60ggagggaagt ccagcaccct gtgtgccagt cctgaactgg cccatctgta gaccccctga120aaatcatatg ggcttggatt tggatattct caacagaaag ggttaaaggc tgatggtacc180taaagcctgg tacttgaatt ttgatcaaga taagctgcct taagttctct tcattacaca240aatgatccta gataattgat agatcctgtg gttcaactgg atttctagat agaagctgga300ttcatgtgat gccagaggag taaaatttca agagactgaa accagatctg agtttcgctg360ttccagtctg gacctctttg gagctgtaaa tcctggatat actgtagatg agtactgcgt420ttttctttta tggactctct tcagcttctg gagacctcac tatcctatta tgtctttgtg480tgaagacatg ctgctttgta attatcgaaa gtgtcgcatc aaactctctg gctatgcatg540ggtcactgcc tgctctcaca tcttctgtga tcagcatggc agtggtgagt ttagtcgctc600accagctatc tgtcctgcct gcaacagtac cctttctgga aagctagata ttgtccgcac660agaactcagt ccatcagagg aatataaagc tatggtattg gcaggactgc gaccagagat720cgtgttggac attagctccc gagcgctggc cttctggaca tatcaggtac atcaggaacg780tctctatcaa gaatacaatt tcagcaaggc tgagggccat ctgaaacaga tggagaagat840atatactcag caaatacaaa gcaaggatgt agaattgacc tctatgaaag gggaggttac900ctccatgaag aaagtactag aagaatacaa gaaaaagttc agtgacatct ctgagaaact960tatggagcgc aatcgtcagt atcaaaagct ccaaggcctc tatgatagcc ttaggctacg1020
aaacatcact attgctaacc atgaaggcac ccttgaacca tccatgattg cacagtctgg1080tgttcttggc ttcccattag gtaacaactc caagtttcct ttggataata cacctgttcg1140aaatcggggc gatggagatg gagattttca gttcagacca ttttttgcgg gttctcccac1200agcacctgaa cccagcaaca gcttttttag ttttgtctct ccaagtcgtg aattagagca1260gcagcaagtt tctagcaggg ccttcaaagt aaaaagaatt tgagccacgc atagtgtcac1320gcacctgtga tcccagctac ttaggaggtt gaggctggga ggatcacttg agcccaggag1380tctgaggctt tagtgatcta agatcatgcc actgcactcc agcctgggca acagagtgag1440accctgtttc taaaaaaaaa taaagataat ttagctaact tcaaaaaaaa aaaaaaaaaa1500aac 1503<210>16<211>5776<212>DNA<213>人<400>16gctcacccag gaaaaatatg caatcgtccc attgatatac aggccactac aatggatgga60gttaacctca gcaccgaggt tgtctacaaa aaaggccagg attataggtt tgcttgctac120gaccggggca gagcctgccg gagctaccgt gtacggttcc tctgtgggaa gcctgtgagg180cccaaactca cagtcaccat tgacaccaat gtgaacagca ccattctgaa cttggaggat240aatgtacagt catggaaacc tggagatacc ctggtcattg ccagtactga ttactccatg300taccaggcag aagagttcca ggtgcttccc tgcagatcct gcgcccccaa ccaggtcaaa360gtggcaggga aaccaatgta cctgcacatc ggggaggaga tagacggcgt ggacatgcgg420gcggaggttg ggcttctgag ccggaacatc atagtgatgg gggagatgga ggacaaatgc480tacccctaca gaaaccacat ctgcaatttc tttgacttcg atacctttgg gggccacatc540aagtttgctc tgggatttaa ggcagcacac ttggagggca cggagctgaa gcatatggga600
cagcagctgg tgggtcagta cccgattcac ttccacctgg ccggtgatgt agacgaaagg660ggaggttatg acccacccac atacatcagg gacctctcca tccatcatac attctctcgc720tgcgtcacag tccatggctc caatggcttg ttgatcaagg acgttgtggg ctataactct780ttgggccact gcttcttcac ggaagatggg ccggaggaac gcaacacttt tgaccactgt840cttggcctcc ttgtcaagtc tggaaccctc ctcccctcgg accgtgacag caagatgtgc900aagatgatca cagaggactc ctacccaggg tacatcccca agcccaggca agactgcaat960gctgtgtcca ccttctggat ggccaatccc aacaacaacc tcatcaactg tgccgctgca1020ggatctgagg aaactggatt ttggtttatt tttcaccacg taccaacggg cccctccgtg1080ggaatgtact ccccaggtta ttcagagcac attccactgg gaaaattcta taacaaccga1140gcacattcca actaccgggc tggcatgatc atagacaacg gagtcaaaac caccgaggcc1200tctgccaagg acaagcggcc gttcctctca atcatctctg ccagatacag ccctcaccag1260gacgccgacc cgctgaagcc ccgggagccg gccatcatca gacacttcat tgcctacaag1320aaccaggacc acggggcctg gctgcgcggc ggggatgtgt ggctggacag ctgccggttt1380gctgacaatg gcattggcct gaccctggcc agtggtggaa ccttcccgta tgacgacggc1440tccaagcaag agataaagaa cagcttgttt gttggcgaga gtggcaacgt ggggacggaa1500atgatggaca ataggatctg gggccctggc ggcttggacc atagcggaag gaccctccct1560ataggccaga attttccaat tagaggaatt cagttatatg atggccccat caacatccaa1620aactgcactt tccgaaagtt tgtggccctg gagggccggc acaccagcgc cctggccttc1680cgcctgaata atgcctggca gagctgcccc cataacaacg tgaccggcat tgcctttgag1740gacgttccga ttacttccag agtgttcttc ggagagcctg ggccctggtt caaccagctg1800gacatggatg gggataagac atctgtgttc catgacgtcg acggctccgt gtccgagtac1860cctggctcct acctcacgaa gaatgacaac tggctggtcc ggcacccaga ctgcatcaat1920
gttcccgact ggagaggggc catttgcagt gggtgctatg cacagatgta cattcaagcc1980tacaagacca gtaacctgcg aatgaagatc atcaagaatg acttccccag ccaccctctt2040tacctggagg gggcgctcac caggagcacc cattaccagc aataccaacc ggttgtcacc2100ctgcagaagg gctacaccat ccactgggac cagacggccc ccgccgaact cgccatctgg2160ctcatcaact tcaacaaggg cgactggatc cgagtggggc tctgctaccc gcgaggcacc2220acattctcca tcctctcgga tgttcacaat cgcctgctga agcaaacgtc caagacgggc2280gtcttcgtga ggaccttgca gatggacaaa gtggagcaga gctaccctgg caggagccac2340tactactggg acgaggactc agggctgttg ttcctgaagc tgaaagctca gaacgagaga2400gagaagtttg ctttctgctc catgaaaggc tgtgagagga taaagattaa agctctgatt2460ccaaagaacg caggcgtcag tgactgcaca gccacagctt accccaagtt caccgagagg2520gctgtcgtag acgtgccgat gcccaagaag ctctttggtt ctcagctgaa aacaaaggac2580catttcttgg aggtgaagat ggagagttcc aagcagcact tcttccacct ctggaacgac2640ttcgcttaca ttgaagtgga tgggaagaag taccccagtt cggaggatgg catccaggtg2700gtggtgattg acgggaacca agggcgcgtg gtgagccaca cgagcttcag gaactccatt2760ctgcaaggca taccatggca gcttttcaac tatgtggcga ccatccctga caattccata2820gtgcttatgg catcaaaggg aagatacgtc tccagaggcc catggaccag agtgctggaa2880aagcttgggg cagacagggg tctcaagttg aaagagcaaa tggcattcgt tggcttcaaa2940ggcagcttcc ggcccatctg ggtgacactg gacactgagg atcacaaagc caaaatcttc3000caagttgtgc ccatccctgt ggtgaagaag aagaagttgt gaggacagct gccgcccggt3060gccacctcgt ggtagactat gacggtgact cttggcagca gaccagtggg ggatggctgg3120gtcccccagc ccctgccagc agctgcctgg gaaggccgtg tttcagccct gatgggccaa3180gggaaggcta tcagagaccc tggtgctgcc acctgcccct actcaagtgt ctacctggag3240
cccctggggc ggtgctggcc aatgctggaa acattcactt tcctgcagcc tcttgggtgc3300ttctctccta tctgtgcctc ttcagtgggg gtttggggac catatcagga gacctgggtt3360gtgctgacag caaagatcca ctctggcagg agccctgacc cagctaggag gtagtctgga3420gggctggtca ttcacagatc cccatggtct tcagcagaca agtgagggtg gtaaatgtag3480gagaaagagc cttggcctta aggaaatctt tactcctgta agcaagagcc aacctcacag3540gattaggagc tggggtagaa ctggctatcc ttggggaaga ggcaagccct gcctctggcc3600gtgtccacct ttcaggagac tttgagtggc aggtttggac ttggactaga tgactctcaa3660aggccctttt agttctgaga ttccagaaat ctgctgcatt tcacatggta cctggaaccc3720aacagttcat ggatatccac tgatatccat gatgctgggt gccccagcgc acacgggatg3780gagaggtgag aactaatgcc tagcttgagg ggtctgcagt ccagtagggc aggcagtcag3840gtccatgtgc actgcaatgc caggtggaga aatcacagag aggtaaaatg gaggccagtg3900ccatttcaga ggggaggctc aggaaggctt cttgcttaca ggaatgaagg ctgggggcat3960tttgctgggg ggagatgagg cagcctctgg aatggctcag ggattcagcc ctccctgccg4020ctgcctgctg aagctggtga ctacggggtc gccctttgct cacgtctctc tggcccactc4080atgatggaga agtgtggtca gaggggagca atgggctttg ctgcttatga gcacagagga4140attcagtccc caggcagccc tgcctctgac tccaagaggg tgaagtccac agaagtgagc4200tcctgcctta gggcctcatt tgctcttcat ccagggaact gagcacaggg ggcctccagg4260agaccctaga tgtgctcgta ctccctcggc ctgggatttc agagctggaa atatagaaaa4320tatctagccc aaagccttca ttttaacaga tggggaaagt gagcccccaa gatgggaaag4380aaccacacag ctaagggagg gcctggggag ccccacccta gcccttgctg ccacaccaca4440ttgcctcaac aaccggcccc agagtgccca ggcactcctg aggtagcttc tggaaatggg4500gacaagtccc ctcgaaggaa aggaaatgac tagagtagaa tgacagctag cagatctctt4560
ccctcctgct cccagcgcac acaaacccgc cctccccttg gtgttggcgg tccctgtggc4620cttcactttg ttcactacct gtcagcccag cctgggtgca cagtagctgc aactccccat4680tggtgctacc tggctctcct gtctctgcag ctctacaggt gaggcccagc agagggagta4740gggctcgcca tgtttctggt gagccaattt ggctgatctt gggtgtctga acagctattg4800ggtccacccc agtccctttc agctgctgct taatgccctg ctctctccct ggcccacctt4860atagagagcc caaagagctc ctgtaagagg gagaactcta tctgtggttt ataatcttgc4920acgaggcacc agagtctccc tgggtcttgt gatgaactac atttatcccc tttcctgccc4980caaccacaaa ctctttcctt caaagagggc ctgcctggct ccctccaccc aactgcaccc5040atgagactcg gtccaagagt ccattcccca ggtgggagcc aactgtcagg gaggtctttc5100ccaccaaaca tctttcagct gctgggaggt gaccataggg ctctgctttt aaagatatgg5160ctgcttcaaa ggccagagtc acaggaagga cttcttccag ggagattagt ggtgatggag5220aggagagtta aaatgacctc atgtccttct tgtccacggt tttgttgagt tttcactctt5280ctaatgcaag ggtctcacac tgtgaaccac ttaggatgtg atcactttca ggtggccagg5340aatgttgaat gtctttggct cagttcattt aaaaaagata tctatttgaa agttctcaga5400gttgtacata tgtttcacag tacaggatct gtacataaaa gtttctttcc taaaccattc5460accaagagcc aatatctagg cattttcttg gtagcacaaa ttttcttatt gcttagaaaa5520ttgtcctcct tgttatttct gtttgtaaga cttaagtgag ttaggtcttt aaggaaagca5580acgctcctct gaaatgcttg tcttttttct gttgccgaaa tagctggtcc tttttcggga5640gttagatgta tagagtgttt gtatgtaaac atttcttgta ggcatcacca tgaacaaaga5700tatattttct atttatttat tatatgtgca cttcaagaag tcactgtcag agaaataaag5760aattgtctta aatgtc5776
<210>17<211>2695<212>DNA<213>人<400>17gcgggcttta gcgccttttc tggcggcggt agatttgaag cgcttcaaag gaccggaccc60agagaagagg aaaactctac cggtgcagga gcacagggat cagttgtcct tgtttttttt120tggtcttttc ttcatttgaa gattaagtat tggagccatg ggaataaagg ttcaacgtcc180tcgatgtttt tttgacattg ccattaacaa tcaacctgct ggaagagttg tctttgaatt240attttctgat gtgtgcccca aaacatgcga gaactttcgt tgtctttgta caggtgaaaa300ggggaccggg aaatcaactc agaaaccatt acattataag agttgtctct ttcacagagt360tgtcaaggat tttatggttc aaggtggtga cttcagtgaa ggaaatggac gaggagggga420atctatctat ggaggatttt ttgaagacga gagtttcgct gttaaacaca acaaagaatt480tctcttgtca atggccaaca gagggaagga tacaaatggt tcacagttct tcataacaac540gaaaccaact cctcatttag atgggcatca tgttgttttt ggacaagtaa tctctggtca600agaagttgta agagagattg aaaaccagaa aacagatgca gctagcaaac cgtttgcgga660ggtacggata ctcagttgtg gagagctgat tcccaaatct aaagttaaga aagaagaaaa720gaaaaggcat aaatcatcat catcttcctc ctcctcatct agtgactcag atagctcaag780tgattctcag tcctcttctg attcctctga ttccgaaagt gctactgaag agaaatcaaa840gaaaagaaaa aagaaacatc ggaaaaattc ccgaaaacac aagaaagaaa agaaaaagcg900aaagaaaagc aagaagagtg catctagtga gagtgaagct gaaaatcttg aagcacaacc960ccagtctact gtccgtccag aagagatccc tcctatacct gaaaatagat tcctaatgag1020aaaaagtcct cctaaagctg atgagaagga aaggaaaaac agagagagag aaagggaaag1080agagtgtaat ccacctaact cccagcctgc ttcataccag agacgacttt tagttactag1140
atctggcagg aaaattaaag gaagaggacc aaggcgttat cgaactcctt ccagatccag1200atcaagggat cgtttcagac gtagtgagac tcctccacat tggaggcaag agatgcagag1260agctcaaaga atgagggtat caagtggtga aagatggatc aagggggata agagtgagtt1320gaatgaaata aaagaaaatc agagaagtcc agttagagta aaagagagaa aaataacaga1380tcacaggaat gtatctgaga gtccaaacag aaaaaatgaa aaggagaaga aagttaaaga1440ccataaatct aacagcaaag agagagacat cagaagaaat tcagaaaaag atgacaagta1500taaaaacaaa gtgaagaaaa gggccaaatc taaaagtagg agtaagagca aagagaaatc1560aaagagtaaa gaaagagatt caaaacataa tagaaatgaa gaaaagagga tgaggtcaag1620gagtaaagga agggatcatg aaaatgttaa agaaaaagaa aagcagtctg attctaaagg1680aaaagatcag gaaaggagta gaagtaaaga gaagtctaaa cagttagaat caaagagtaa1740tgagcatgat cacagtaaaa gtaaggaaaa ggatagacgc gcacaatcca ggagtagaga1800atgtgatata actaaaggta aacacagtta taatagcaga acaagagaac gaagcagaag1860tagggacaga agcagaagag tgcgatcaag aacccatgac agagatcgca gcagaagcaa1920ggagtaccat agatacagag aacaggaata caggagaaga ggacggtcac gaagccgaga1980gagaagaaca ccaccaggaa gatcaagaag taaagatagg aggagaagga ggagagactc2040acggagctca gagagagaag aaagtcaaag cagaaacaaa gacaaataca gaaaccaaga2100gagtaagagc tcacacagaa aagaaaattc tgagagtgag aaaagaatgt actctaaaag2160tcgtgatcat aatagctcaa ataacagcag ggaaaaaaag gctgatagag atcaaagtcc2220cttctcaaaa ataaaacaaa gcagtcagga cgatgaatta aagtcctcca tgttgaaaaa2280taaggaggat gagaagatca gatcctcagt ggaaaaagaa aaccaaaaat caaaaggtca2340agaaaatgac catgtacatg aaaaaaataa aaaatttgat catgaatcaa gccctggaac2400agatgaagac aaaagcggat gagtgagtta tataaactta cttccattct gtttcggatt2460
ttaagtttga gagacttgct aatgaatctc ctttatgttg ttttcctttt cattgttttt2520ggattgtttt atgtttgtcc ttttttttct taatgtggat ttcattgagt tgattttttg2580ataatctgca atctggataa tttgtactgc taaagtttta ataaactcga catgagaaaa2640acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2695<210>18<211>1635<212>DNA<213>人<400>18ggcacgagcg cggcgttcac gggaattgtt cgctttagtg ccggcgccat ggggtcggag60ctgatcgggc gcctagcccc gcgcctgggc ctcgccgagc ccgacatgct gaggaaagca120gaggagtact tgcgcctgtc ccgggtgaag tgtgtcggcc tctccgcacg caccacggag180accagcagtg cagtcatgtg cctggacctt gcagcttcct ggatgaagtg ccccttggac240agggcttatt taattaaact ttctggtttg aacaaggaga catatcagag ctgtcttaaa300tcttttgagt gtttactggg cctgaattca aatattggaa taagagacct agctgtacag360tttagctgta tagaagcagt gaacatggct tcaaagatac taaaaagcta tgagtccagt420cttccccaga cacagcaagt ggatcttgac ttatccaggc cacttttcac ttctgctgca480ctgctttcag catgcaagat tctaaagctg aaagtggata aaaacaaaat ggtagccaca540tccggtgtaa aaaaagctat atttgatcga ctgtgtaaac aactagagaa gattggacag600caggtcgaca gagaacctgg agatgtagct actccaccac ggaagagaaa gaagatagtg660gttgaagccc cagcaaagga aatggagaag gtagaggaga tgccacataa accacagaaa720gatgaagatc tgacacagga ttatgaagaa tggaaaagaa aaattttgga aaatgctgcc780agtgctcaaa aggctacagc agagtgattt cagcttccaa actggtatac attccaaact840gatagtacat tgccatctcc aggaagactt gacggctttg ggattttgtt taaactttta900
taataaggat cctaagactg ttgcctttaa atagcaaagc agcctacctg gaggctaagt960ctgggcagtg ggctggcccc tggtgtgagc attagaccag ccacagtgcc tgattggtat1020agccttatgt gctttcctac aaaatggaat tggaggccgg gcgcagtggc tcacgcctgt1080aatcccagca ctttgggagg ccaaggtggg tggatcacct gaggtcagga gctcgagacc1140agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaatta gccaggtgtg1200atggtgcatg cctgtaatcc cagctcctca gtaggctgag acaggagcat cacttgaacg1260tgggaggcag aggttgcagt gagccgagat tgcaccaccg cactccagcc tgggtgacag1320agcgagactt atctcataaa taaatagata gatactccag cctgggtgac agagcgagac1380ttatagatag atagatagat agatggatag atagatagat agatagatag atagataaac1440ggaattggag ccattttgct ttaagtgaat ggcagtccct tgtcttattc agaatataaa1500attcagtctg aatggcatct tacagatttt acttcaattt ttgtgtacgg tattttttat1560ttgactaaat caatatattg tacagcctaa gttaataaat gttatttata tatgcaaaaa1620aaaaaaaaaa aaaaa 1635<210>19<211>3165<212>DNA<213>人<400>19ggggatttgg ctagaaggct gggccggcag cggttgtgag gagttagctc gcggcattgc60aggctctgag aggaggggac ccggttcccg ggtgagtgtc caggcatgcc agcggaacgg120cccgcgggca gcggcggctc ggaggctcca gcaatggttg aacaactgga cactgctgtg180attaccccgg ccatgctaga agaggaagaa cagcttgaag ctgctggact agagagagag240cggaagatgc tggaaaaggc tcgcatgtct tgggatagag agtcgacaga aattcggtac300
cgtagacttc aacatttgct tgaaaaaagc aatatatact ccaaattttt attgacgaaa360atggaacagc aacaattaga ggaacagaag aagaaagaaa aattggagag aaaaaaggag420tctttaaaag ttaaaaaggg taaaaattca attgatgcaa gtgaagagaa gccagttatg480aggaaaaaaa gaggaagaga agatgaatca tacaatattt cagaggtcat gtcaaaagag540gaaattttgt ctgtggctaa aaaaaataaa aaggagaatg aggatgaaaa ctcctcctct600actaatctct gtgtggaaga tcttcagaaa aataaagatt cgaatagtat aattaaagat660agattgtctg aaacggttag gcagaatact aaattctttt ttgacccagt ccggaagtgt720aatggtcagc cagtaccttt tcaacaacca aagcacttca ctggaggagt gatgcgatgg780taccaagtag aaggcatgga atggcttagg atgctttggg aaaatggaat taatggcatt840ttagcagatg aaatgggatt gggtaagaca gttcagtgca ttgctactat tgcattgatg900attcagagag gagtaccagg accttttctt gtctgtggcc ctttgtctac acttcctaac960tggatggctg aattcaaaag atttacacca gatatcccta caatgttata tcatggaacc1020caggaggaac gtcaaaaatt ggtaagaaat atttacaaac ggaaagggac tttgcagatt1080catcctgtgg taatcacgtc atttgaaata gccatgagag accgaaatgc gttacagcat1140tgctattgga aatacttaat agtagatgaa ggacacagga ttaagaatat gaagtgccgt1200ctaatcaggg agttaaaacg attcaatgct gataacaaac ttcttttgac tggtactccc1260ttgcaaaaca atttatcaga actttggtca ttgctaaact ttttgttgcc agatgtattt1320gatgacttga aaagctttga gtcttggttt gacatcacta gtctttctga aactgctgaa1380gatattattg ctaaagaaag agaacagaat gtattgcata tgctgcacca gattttaaca1440cctttcttat tgagaagact gaagtctgat gttgctcttg aagttcctcc taaacgagaa1500gtagtcgttt atgctccact ttcaaagaag caggagatct tttatacagc cattgtgaac1560cgtacaattg caaacatgtt tggatccagt gagaaagaaa caattgagtt aagtcctact1620
ggtcgaccaa aacgacgaac tagaaaatca ataaattaca gcaaaataga tgatttccct1680aatgaattgg aaaaactgat cagtcaaata cagccagagg tggaccgaga aagagctgtt1740gtggaagtga atatccctgt agaatctgaa gttaatctga agctgcagaa tataatgatg1800ctacttcgta aatgttgtaa tcatccatat ttgattgaat atcctataga ccctgttaca1860caagaattta agatcgatga agaattggta acaaattctg ggaagttctt gattttggat1920cgaatgctgc cagaactaaa aaaaagaggt cacaaggtgc tgcttttttc acaaatgaca1980agcatgttgg acattttgat ggattactgc catctcagag atttcaactt cagcaggctt2040gatgggtcca tgtcttactc agagagagaa aaaaacatgc acagcttcaa cacggatcca2100gaggtgttta tcttcttagt gagtacacga gctggtggcc tgggcattaa tctgactgca2160gcagatacag ttatcattta tgatagtgat tggaaccccc agtcggatct tcaggcccag2220gatagatgtc atagaattgg tcagacaaag ccagttgttg tttatcgcct tgttacagca2280aatactatcg atcagaaaat tgtggaaaga gcagctgcta aaaggaaact ggaaaagttg2340atcatccata aaaatcattt caaaggtggt cagtctggat taaatctgtc taagaatttc2400ttagatccta aggaattaat ggaattatta aaatctagag attatgaaag ggaaataaaa2460ggatcaagag agaaggtcat tagtgataaa gatctagagt tgttgttaga tcgaagtgat2520cttattgatc aaatgaatgc ttcaggacca attaaagaga agatggggat attcaagata2580ttagaaaatt ctgaagattc cagtcctgaa tgtttgtttt aaagtggagc tcaagaatag2640cttttaaaag ttcttattta catctagtga tttccctgta ttgggtttga aatactgatt2700gtccacttca ccttttttat tatatcagtt gacatgtaac tagtaccatg cgtacttaaa2760tagatggtaa ttttctgagc cttaccaaga acaaagaagt atccatatta agtttagatt2820ttcagttaat ttttgagact gagtagtatt cttggataca ggctgatgtg tacttaacca2880cttccagatt tatacagtct tcctgtggaa gtttagtaaa tgtctttttc cctcctttct2940
tctagtaatg cagttcatgg gctttaggta cttcagttat gaagtaggct tttcatgggg3000agagattggg attatgctct ctgttgttta agaaactgtt tgattttaga gtctatttct3060atgagatagt ttaccaaata aatgttcctt ataagatgaa aaaaaaaaaa aaaaaaaaaa3120aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa3165<210>20<211>526<212>DNA<213>人<400>20tggttcctgc cgtccggact ctttttcctc tactgagatt catctgtgtg aaatatgagt60tggcgaggaa gatcgaccta ttattggcct agaccaaggc gctatgtaca gcctcctgaa120atgattgggc ctatgcggcc cgagcagttc agtgatgaag tggaaccagc aacacctgaa180gaaggggaac cagcaactca acgtcaggat cctgcagctg ctcaggaggg agaggatgag240ggagcatctg caggtcaagg gccgaagcct gaagctcata gccaggaaca gggtcaccca300cagactgggt gtgagtgtga agatggtcct gatgggcagg agatggaccc gccaaatcca360gaggaggtga aaacgcctga agaaggtgaa aagcaatcac agtgttaaaa gaaggcacgt420tgaaatgatg caggctgctc ctatgttgga aatttgttca ttaaaattct cccaataaag480ctttacagcc ttctgcaaag aaaaaaaaaa aaaaaaaaaa aaaaaa 526<210>21<211>4834<212>DNA<213>人<400>21cgaggtcaga ggggaggagg actctggagc tgacagcgcg cacttcaccc gcagttgttc60tagcgactgc gaagatagct cgctgagctg gaaccccaca gatcaccaac aaaaatgaag120
gcggcagatg agcctgccta cctgacagtg ggaaccgatg tcagtgccaa gtaccgaggt180gccttctgtg aggcaaagat taagactgtg aaaaggctgg tgaaagttaa ggtactcctg240aaacaggata ataccacaca attggtacaa gatgaccaag taaagggtcc tttaagagtt300ggagctattg ttgaaacaag gacatctgat ggatcttttc aggaagctat tatcagcaag360ttgacagatg ctagttggta taccgtggtg tttgatgatg gtgatgagcg aacattgaga420cgtacctcac tttgtctgaa aggagagaga cattttgcag agagtgagac acttgaccag480cttccattaa caaatccaga gcattttgga actccagtaa ttgcaaagaa gacgaacaga540ggaaggagat cttctcttcc tgttactgaa gatgaaaagg aagaagaaag cagtgaagag600gaagatgaag acaagcgccg tctcaatgat gaattactag gaaaagttgt aagtgtggtg660tctgcaacgg agaggactga atggtatcct gctttggtaa tatctcccag ctgtaatgat720gacatcacag tgaaaaagga tcagtgttta gttcgatcat ttattgattc taaattttac780tctatagcaa gaaaggacat taaggaagta gacattctca atctaccgga atctgagctc840tccactaaac cagggcttca gaaagcaagc atcttcttaa aaactagagt tgttcctgat900aattggaaaa tggatataag tgaaatcctt gagtcatcca gtagtgatga tgaagatggc960ccagctgaag aaaatgatga agagaaggaa aaggaggcca aaaagacaga agaagaggtg1020cctgaggaag aacttgatcc tgaagagagg gacaacttcc tccagcagct ttataagttt1080atggaagaca gaggtactcc aatcaacaaa ccacctgttt tgggctataa agatctcaat1140ctcttcaaac tcttcagact ggtttatcat cagggtggat gtgacaatat tgatagtggt1200gctgtatgga agcaaattta tatggacctt ggcattccta ttttgaattc agctgcttcc1260tacaatgtaa aaactgctta tagaaagtat ctctatggtt ttgaggagta ctgccgttcg1320gcaaatattc agttcagaac tgttcatcac catgaaccaa aagtaaaaga ggaaaaaaaa1380gacttagaag aatcaatgga agaggctctc aaattagatc aagaaatgcc tttaacagaa1440
gtgaagagtg aacctgagga aaatatcgat tcaaacagtg aaagtgaaag agaagagata1500gaattaaaat ctccgagggg acgaaggaga attgctcgag atgtaaattc tattaaaaag1560gaaattgaag aagagaaaac agaagacaaa ttaaaagata atgatacaga aaataaggat1620gtagatgatg actatgaaac tgcagagaaa aaagaaaatg agctactact ggggagaaaa1680aatacaccaa agcaaaaaga gaagaaaatt aaaaaacagg aggattctga caaagactca1740gatgaagagg aagagaaaag ccaagagagg gaagaaactg aaagcaaatg tgactctgaa1800ggagaggaag atgaggaaga catggaaccc tgcctaacag gaaccaaagt gaaagtaaaa1860tatggacgag ggaagactca gaaaatttat gaagccagta ttaaaagcac tgaaattgat1920gacggagaag ttttatattt ggtacattac tatggatgga atgtcaggta tgatgagtgg1980gtgaaggctg acaggataat ctggcctttg gacaaaggtg gaccaaagaa aaaacagaag2040aaaaaagcta aaaataaaga agatagtgaa gtggacgaaa agagagatga ggagaggcag2100aagtcaaaac ggggacgacc tcctttaaaa tcaaccctct catcaaacat gccgtatggc2160ttatctaaga cagcaaacag tgaaggaaaa tcagactctt gttcatctga tagtgaaaca2220gaagatgctt tagaaaagaa tttaataaat gaagaacttt ctcttaaaga tgaactagaa2280aaaaatgaaa atttgaatga tgataagcta gatgaagaaa atccaaagat ttctgcacat2340atattaaaag aaaatgatag gactcaaatg cagcctttag aaaccctgaa gttagaagtt2400ggagagaatg aacaaatagt acagattttt gggaacaaaa tggaaaaaac agaagaagtt2460aagaaagaag ccgaaaaatc tccaaaagga aagggaagac gaagcaagac aaaagatctt2520tctttagaaa ttataaagat ttcatcattt ggccagaatg aagcaggaag tgaacctcat2580atagaagctc atagtcttga attgtcttca ttagacaata aaaacttttc ttctgctaca2640gaagatgaaa ttgaccaatg tgtgaaagaa aagaagttga aacggaaaat actaggacaa2700tcatcgccag agaaaaaaat aagaattgag aatggaatgg aaatgacaaa tactgtatct2760
caagaaagga ccagtgattg tattggatct gagggaatga aaaacttaaa ttttgaacag2820cactttgaaa gagaaaatga aggaatgcca tcattgatag cagagtcaaa ccaatgcatc2880caacaactga ctagtgaaag atttgatagt ccagctgaag aaactgtaaa tattccacta2940aaagaagatg aggatgcaat gcctctgatc gggcctgaaa ccttggtttg ccatgaagta3000gatttggatg atttggatga aaaggataag accagcattg aggatgtagc agttgaaagc3060tctgagtcta actctcttgt ttctattcca cctgccctac ctcctgtagt ccaacataac3120ttttcagtag cttcaccact tactcttagt caagatgagt ctcgaagcgt aaaaagtgag3180agtgatataa cgattgaagt tgatagtatt gctgaagaat ctcaagaagg tctctgtgag3240agggaatcgg caaatggatt tgaaactaat gttgcctctg gtacctgtag tataattgta3300caagagagag agagcagaga gaagggtcag aagaggccaa gtgatggaaa tagtggatta3360atggcaaaaa agcaaaagcg taccccaaag cgaacaagtg ctgcagccaa aaatgaaaag3420aatggaacag gacaaagcag tgatagtgaa gatcttcctg tcctagacaa ttcaagtaaa3480tgtaccccag taaagcatct taatgtatct aagccacaga aacttgcacg atctcctgca3540agaatatccc cgcacatcaa agatggagag aaagataaac acagagaaaa acatccgaat3600tcatccccta ggacatataa atggagcttt cagctcaatg aattagataa tatgaacagt3660acagagagaa tctcatttct ccaagaaaaa ctacaggaaa tcagaaaata ttatatgtct3720ttgaagtctg aagttgcaac catagacagg aggagaaaaa gattaaaaaa gaaagacagg3780gaagtgtctc atgcgggagc ctccatgtca tctgcttcat cagacactgg aatgagtccc3840tcatcatcgt ctcccccaca aaatgtactt gctgtagaat gtaggtgata aacattttct3900ctaccttccc agcagtttgc tgccatggac ataaatcccc aaaccctgaa ttacaaccac3960agaaagcact caactggttt gacattgcta agtatatcct gtatactttt ccaggctgga4020ttgtatctat gcccctctct cttctttttt cttgttgcaa aaaataagct gattaataag4080
tgaaggttaa gcagcctgcc atatttgtca taatttttcc tctttacttt tgtttttcgt4140ttgttgtgat atagaacaaa gggcacttag caaatttgaa tttgtataat aaagctttca4200ggtgttacag aaatcgtaga caagcaagtg cacatgataa acaatcaaaa tattacccag4260ctgaatagtt actgctgcac tttcactaag atgtatttga acacttggtg agtagggggt4320ttatgttgtg ttttttttca ttatcgtttt ttttattttt gtgaagcact tgctatttag4380aactgccaaa gtatatgttc agcagtgtgc ccaggattga aggtgtaaat gggacaaaat4440aaattgtgaa aggaagtgta gttgactgaa aactacagtt gtaataagtc ttccactttt4500tataggattt ttgagcacac aattatgcaa atattttaat gtttattaat gtttacagtg4560gaattgtgaa taagttttca gtggactatc ttatcccttg acaaaaatat tttgtctttt4620ttctatgtaa tttcagagtt tttattttgt tacaaaaaga caaaaatgaa atatataaca4680acaatgaagt tatttaacaa gatttctaaa gctgaaattt ttgtgtaaaa taaggtatta4740tcttgcaact tgttaaatat atttattcag acattggatg ttgtattttt atgtattttt4800taaaatatta ataaaattta aaaaaaaaaa aaaa4834<210>22<211>1713<212>DNA<213>人<400>22ggggggtgtg agccacgggc tgccgggggc ctggggctcg gcgtcggtcc ccgggggatg60tggagagctg gcagcatgtc ggccgagctg ggagtcgggt gcgcattgcg ggcggtgaac120gagcgcgtgc agcaggctgt ggcgcggcgg ccgcgggatc tcccagccat ccagccccgg180ctagtggcgg tcagcaaaac caaacctgca gacatggtga tcgaggccta tggacatggg240cagcgcactt ttggcgagaa ctacgttcag gaactgctag aaaaagcatc aaatcccaaa300attctgtctt tgtgtcctga gatcaaatgg cacttcattg gccacctaca gaaacaaaat360
gtcaacaaat tgatggctgt ccccaatctc ttcatgctgg aaacagtgga ttctgtgaag420ttggcagaca aagtgaacag ttcctggcag agaaaaggtt ctcctgaaag gttaaaggtt480atggtccaga ttaacaccag cggagaagag agtaaacatg gccttccacc ttcagagacc540atagccatcg tggagcacat aaacgccaag tgtcctaacc tggagtttgt ggggctgatg600accataggaa gctttgggca tgatcttagt caaggaccaa atccagactt ccagctgtta660ttgtccctcc gggaggagct gtgtaaaaag ctgaacatcc ctgctgacca ggttgagctg720agcatgggca tgtccgcgga tttccagcat gcggttgaag taggatctac aaatgtccga780ataggaagca cgatttttgg agagcgggat tactcaaaga aacccacccc ggacaagtgc840gcagcagacg tgaaggcccc gctggaggtg gcacaggagc actgagccag ggaatactga900gagcactaac tatgcactaa cctagatttt catttcgata ttccctgtgt cccagcgcag960tcctgctctc ctgtgacctg tggagagcac taatgatcac gtgtgttgat ggaaaccatc1020tgtgcttagt ctctgacata ggaagcttgc ttcaggcaat ggctttggat tgagtttgag1080aaattcaaac atttctgcag aacagatacc aaatcaatag ctaggaatca tgttcaatat1140tgaattctgc ccaggagcat gaactgatcc atgaatgcct tttccaggtt aaaatttggt1200cactgatgcc tataatcgtg gaagtcagag ggattcccct ttttcatctc attttaatag1260gaaaattcct tatggttaac atctccctac aaactcctac tacgtcgtct aaattgctgc1320tctggaataa ggtgatttct gcccccagat tcttccctag ccggtagata cgtgaagata1380ttcccaactg tggaatggca gtgtaggtag cttcaggaaa tggctcaggt taattctcaa1440aacacaaatt gttgctggcc aggcatggtg actcatgcct gtaatcccag caatttggga1500gacagaggcg gaaggatcac ctgagcctag gagttcaaga ccagcctcag caacagcagg1560agccccaccc cccgtctcta caaaaatatt taaaaattaa ctgggcatgg tggctgaggt1620ggaagaatgg aagaatcact tgagcccagg agtttgaggc tgcagtgagc tatgattgca1680
ccactgtact cctgccttaa aaaaaaaaaa aaa 1713<210>23<211>4344<212>DNA<213>人<400>23gggatctgct agaagttggt cttccgccag gactagagtt tcctcgcggt aacagcctcc60gtggcctccg gaggaccatg tcattagact ttggcagtgt ggcactacca gtgcaaaatg120aagatgaaga gtatgacgaa gaggactatg aaagagagaa agagttgcag cagttactca180cagaccttcc ccatgacatg ctggatgacg acctctcctc tccagagctc cagtattcgg240actgcagcga ggatggcaca gacggacaac cacatcatcc tgagcaattg gagatgagct300ggaatgagca aatgctgccc aaatctcaaa gtgtaaatgg tcccagttgt caaggtttgg360aaccgtataa taaagtgaca tataaacctt atcagtcttc tgcccagaat aatggctcac420cagcccagga gataacagga agtgacacat tcgaaggcct gcaacaacaa tttttaggag480ctaatgagaa ctctgcagaa aatatgcaga ttattcaact tcaggttctt aacaaagcaa540aagagagaca actggagaac ttaattgaaa agttaaatga aagtgaacgt caaattcgat600atctgaatca ccagcttgta ataataaaag atgaaaagga tggtttgact ctcagccttc660gagaatcaca gaaactcttt cagaatggaa aagaaagaga gatacagctt gaagctcaaa720taaaagcact ggagactcag atacaagcat taaaagtcaa tgaagaacag atgatcaaga780agtccagaac aactgaaatg gctctggaaa gcttgaagca gcagctggtg gaccttcatc840attctgaatc acttcaacga gctagagaac agcatgagag cattgttatg ggcctcacaa900agaagtacga agagcaagta ttgtccttac aaaagaattt ggatgccaca gtcaccgcac960ttaaagaaca ggaagacatt tgctctcgtc tgaaagatca cgtgaaacaa ctggaaagga1020
atcaagaagc aatcaagtta gaaaagactg agatcattaa taagttgaca agaagtctag1080aggagagtca aaagcagtgt gcccacttgt tgcagtccgg gtcagtacaa gaggtggctc1140agctacagtt ccagctgcag caagcacaga aggcacatgc tatgagtgca aacatgaaca1200aggctttgca agaagaatta acagaactaa aagatgaaat ttctctctat gaatctgctg1260caaaactagg aatacatcca agtgactcag aaggagaatt aaatatagaa ctcactgaat1320cgtatgtgga tttgggtatt aaaaaggtca actggaaaaa atccaaagtt accagcattg1380tacaagaaga agacccaaat gaagagcttt caaaagatga gttcattctg aagttaaagg1440cagaagtaca gcgtttgctg ggtagcaact caatgaagcg tcatctggtg tctcagttac1500aaaatgacct caaagactgt cataagaaaa ttgaagatct ccaccaagtg aagaaggatg1560aaaaaagcat tgaggttgag actaaaacag atacctcaga aaaaccaaag aatcaattat1620ggcctgagtc ttctacttct gatgttgtca gagatgatat tctgctgctt aaaaatgaaa1680ttcaagtttt acaacaacaa aatcaggaac ttaaagaaac tgaaggaaaa ctgagaaata1740caaatcaaga cttatgtaat caaatgagac aaatggtaca agattttgac catgacaaac1800aagaagctgt ggataggtgt gaaaggactt atcagcagca ccatgaagcc atgaaaactc1860aaatacgtga aagcctatta gcaaagcatg ctttggagaa gcagcagctc tttgaggctt1920atgagagaac tcatttgcaa ctgaggtctg agttggataa gttgaataag gaggtgactg1980ctgtgcagga atgttaccta gaagtgtgca gagagaagga taatctagaa ttgactctca2040ggaagaccac tgaaaaggag caacagactc aggagaagat caaagaaaaa ctcattcaac2100agcttgaaaa ggagtggcag tctaagctgg atcaaactat aaaggcaatg aaaaagaaga2160ccttagattg tggcagccaa actgaccaag taaccaccag tgatgttatt tccaagaaag2220agatggcaat tatgatagaa gagcagaagt gcacaatcca gcaaaactta gaacaagaga2280aggacatagc catcaagggg gctatgaaga aactcgaaat tgaattggaa ctcaaacatt2340
gtgaaaatat taccaaacag gtagaaatag ctgtgcaaaa tgctcatcag cgatggctgg2400gagaactacc agagctggca gagtatcaag cacttgtgaa ggcagaacag aaaaagtggg2460aagaacagca tgaggtctct gtgaacaaaa ggatatcatt tgctgtttct gaagctaaag2520agaaatggaa gagtgagctt gaaaatatga ggaaaaatat acttcctgga aaggaattgg2580aagagaagat tcattctctt cagaaggaac ttgagttaaa gaacgaagaa gtccctgtgg2640tcatcagggc tgagttagct aaggctcgga gtgaatggaa caaagaaaag caagaagaaa2700tccacagaat ccaagaacaa aatgagcaag attaccggca atttttagat gatcaccgaa2760ataaaattaa tgaggtgctt gcggcagcta aagaagactt tatgaaacaa aaaactgaac2820tacttcttca gaaggagaca gaattacaaa cttgtctaga ccagagtcgt agagaatgga2880ctatgcagga agccaagcgg atccaactgg aaatctatca gtatgaggaa gacatcctga2940ctgtacttgg ggttctttta agtgataccc aaaaggagca catcagtgat tctgaggaca3000agcagctttt ggaaatcatg tcgacttgtt cttcaaaatg gatgtctgtg caatattttg3060aaaaactaaa gggctgcata cagaaagcat ttcaagatac acttcctctg cttgtagaaa3120acgctgaccc agaatggaaa aagagaaata tggccgagct ctctaaggat tctgccagcc3180agggcactgg ccaaggagac cctggacctg ctgctggaca ccatgctcag cccttggcct3240tacaagcaac agaagcagaa gctgataaga aaaaggtcct tgaaattaag gatttatgct3300gtggacactg cttccaagaa cttgaaaagg caaagcagga atgtcaagat ctgaaaggaa3360aactggagaa atgctgtagg catcttcagc atttagaaag gaagcacaaa gctgtagtgg3420aaaaaattgg agaagagaat aataaagttg ttgaagaatt aatagaagaa aacaacgaca3480tgaagaataa attggaagaa ttgcaaacac tttgtaaaac accaccaagg tcattgtcag3540caggggccat tgaaaatgct tgcctgccat gcagtggggg agccttggaa gaacttcgtg3600ggcagtacat taaagctgta aaaaaaatta aatgtgacat gcttcgttat attcaggaga3660
gtaaggaacg agctgcagaa atggtaaaag cagaggtact gcgagaacgt caagaaaccg3720cccgaaagat gcgcaaatat tatttgattt gcctccaaca gattttgcag gatgatggaa3780aagaaggggc tgagaaaaag attatgaatg ctgctagcaa acttgctaca atggcaaaat3840tactggaaac acctatttct agtaagtccc aaagcaaaac tacacagtca ggtatgtcaa3900agtgagtcgc caaatggttt ttctatcttt tcttctttag ctatttaata ttttcagtat3960gaagaaggca gggaaggtaa ggagtgagag ttaatttgtg aagttttgta tgttttactt4020aaactagaag tttacgcaaa aagagtacac agtttccaat ttaagtaggc agactgagca4080tgcccatcag tttcctattg ctgcttccat ccctcgaaat gatagaaaag attttaaaca4140gcaaataaag aatgagaaaa agaagaaatt ataagtgggt tttaaaaagt tgcagtgggc4200caggcatcat ggctcacacc tgtaatccca gcactttggg aggctgaggt gggaggatcc4260cttgatccca ggaatttgag gttgcagtaa gctatgattg tgccactgta ctccagcctg4320ggtgacagag tgaggccctg tctc 4344<210>24<211>552<212>DNA<213>人<400>24ctcatatttc acacagatga gttggcgagg aagatcgacc tattattggt ctaggccaat60aataggtcga tcttcctcgc caactcatat ttcacacaga tgaatctcag tagaggaaaa120tcgacctatt attggcctag accaaggcgc tatgtacagc ctcctgaagt gattgggcct180atgcggcccg agcagttcag tgatgaagtg gaaccagcaa cacctgaaga aggggaacca240gcaactcaac gtcaggatcc tgcagctgct caggagggag aggatgaggg agcatctgca300ggtcaagggc cgaagcctga agctgatagc caggaacagg gtcacccaca gactgggtgt360gagtgtgaag atggtcctga tgggcaggag atggacccgc caaatccaga ggaggtgaaa420
acgcctgaag aaggtgaaaa gcaatcacag tgttaaaaga aggcacgttg aaatgatgca480ggctgctcct atgttggaaa tttgttcatt aaaattctcc caataaagct ttacagcctt540ctgcaaagaa aa552<210>25<211>2899<212>DNA<213>人<400>25aaaaaaaaaa gtacgcggac aagatggcgg cggcagcagt cgacagcgcg atggaggtgg60tgccggcgct ggcggaggag gccgcgccgg aggtagcggg cctcagctgc ctcgtcaacc120tgccgggtga ggtgctggag tacatcctgt gctgcggctc gctgacggcc gccgacatcg180gccgtgtctc cagcacctgc cggcggctgc gcgagctgtg ccagagcagc gggaaggtgt240ggaaggagca gttccgggtg aggtggcctt cccttatgaa acactacagc cccaccgact300acgtcaattg gttggaagag tataaagttc ggcaaaaagc tgggttagaa gcgcggaaga360ttgtagcctc gttctcaaag aggttctttt cagagcacgt tccttgtaat ggcttcagtg420acattgagaa ccttgaagga ccagagattt tttttgagga tgaactggtg tgtatcctaa480atatggaagg aagaaaagct ttgacctgga aatactacgc aaaaaaaatt ctttactacc540tgcggcaaca gaagatctta aataatctta aggcctttct tcagcagcca gatgactatg600agtcgtatct tgaaggtgct gtatatattg accagtactg caatcctctc tccgacatca660gcctcaaaga catccaggcc caaattgaca gcatcgtgga gcttgtttgc aaaacccttc720ggggcataaa cagtcgccac cccagcttgg ccttcaaggc aggtgaatca tccatgataa780tggaaataga actccagagc caggtgctgg atgccatgaa ctatgtcctt tacgaccaac840tgaagttcaa ggggaatcga atggattact ataatgccct caacttatat atgcatcagg900
ttttgattcg cagaacagga atcccaatca gcatgtctct gctctatttg acaattgctc960ggcagttggg agtcccactg gagcctgtca acttcccaag tcacttctta ttaaggtggt1020gccaaggcgc agaaggggcg accctggaca tctttgacta catctacata gatgcttttg1080ggaaaggcaa gcagctgaca gtgaaagaat gcgagtactt gatcggccag cacgtgactg1140cagcactgta tggggtggtc aatgtcaaga aggtgttaca gagaatggtg ggaaacctgt1200taagcctggg gaagcgggaa ggcatcgacc agtcatacca gctcctgaga gactcgctgg1260atctctatct ggcaatgtac ccggaccagg tgcagcttct cctcctccaa gccaggcttt1320acttccacct gggaatctgg ccagagaagg tgcttgacat cctccagcac atccaaaccc1380tagacccggg gcagcacggg gcggtgggct acctggtgca gcacactcta gagcacattg1440agcgcaaaaa ggaggaggtg ggcgtagagg tgaagctgcg ctccgatgag aagcacagag1500atgtctgcta ctccatcggg ctcattatga agcataagag gtatggctat aactgtgtga1560tctacggctg ggaccccacc tgcatgatgg gacacgagtg gatccggaac atgaacgtcc1620acagcctgcc gcacggccac caccagcctt tctataacgt gctggtggag gacggctcct1680gtcgatacgc agcccaagaa aacttggaat ataacgtgga gcctcaagaa atctcacacc1740ctgacgtggg acgctatttc tcagagttta ctggcactca ctacatccca aacgcagagc1800tggagatccg gtatccagaa gatctggagt ttgtctatga aacggtgcag aatatttaca1860gtgcaaagaa agagaacata gatgagtaaa gtctagagag gacattgcac ctttgctgct1920gctgctatct tccaagagaa cgagactccg gaagaagacg tctccacgga gccctcggga1980cctgctgcac caggaaagcc actccaccag tagtgctggt tgcctcctac taagtttaaa2040taccgtgtgc tcttccccag ctgcaaagac aatgttgctc tccgcctaca ctagtgaatt2100aatctgaaag gcactgtgtc agtggcatgg cttgtatgct tgtcctgtgg tgacagtttg2160tgacattctg tcttcatgag gtctcacagt cgacgctcct gtaatcattc tttgtattca2220
ctccattccc ctgtctgtct gcatttgtct cagaacattt ccttggctgg acagatgggg2280ttatgcattt gcaataattt ccttctgatt tctctgtgga acgtgttcgg tcccgagtga2340ggactgtgtg tctttttacc ctgaagttag ttgcatattc agaggtaaag ttgtgtgcta2400tcttggcagc atcttagaga tggagacatt aacaagctaa tggtaattag aatcatttga2460atttattttt ttctaatatg tgaaacacag atttcaagtg ttttatcttt ttttttttaa2520atttaaatgg gaatataaca cagttttccc ttccatattc ctctcttgag tttatgcaca2580tctctataaa tcattagttt tctattttat tacataaaat tcttttagaa aatgcaaata2640gtgaactttg tgaatggatt tttccatact catctacaat tcctccattt taaatgacta2700cttttatttt ttaatttaaa aaatctactt cagtatcatg agtaggtctt acatcagtga2760tgggttcttt ttgtagtgag acatacaaat ctgatgttaa tgtttgctct tagaagtcat2820actccatggt cttcaaagac caaaaaaatg aggttttgct tttgtaatca ggaaaaaaaa2880aaattaatga accttaaag 2899<210>26<211>2289<212>DNA<213>人<400>26ttgtaccctt aaaattattt tttcctatgc agaattgact ttgattaaaa aatgtttttg60atgactattt tcctgattcg tcagtatatc taattgtgtt catattactc atgaaaaatc120ttgtctatga gggacgtatt tttagtaaca tttttatagc atataagaac ttttacagca180aaaacaggaa tcattaagtg tgtgtgcttt tatcataact tctcttttaa tggaacttaa240aatcttaact cgtgtttttg cagcactttt tttgcacatg gtaggttctt aatatttgaa300tggaattcag tgtgactgtt ctttgtgttc tcaaaagtct gatctttgta acaatttgtc360tttcacttga gacttttttt ttctttgcat atgtgcacgt ctcactcttg gttttcctta420
atctttttta actaaacaca tctatgactc atatttccct atttatgaat aggagcaatt480taaaatttcc caacatggtg gtatgtgatg taacataacc aaaggctaca tgtttaccct540tgtttaatta cccttcattt gtggaaagat gacgtatgta tttatgatgt aaatgtcttt600cagaatgacc tttgggacta agcttttttt ttttttttcc caccaaaaaa tggtcatgac660ctaggaagcc ttgttagtaa aatttaaaaa ggaaaagttg gctgggcatg gtggctcatg720cctgtaatct caacactctg ggaggccgag gtgggtgtat caattgaggt cagagttcga780gaccagcctg ggtaacatgg tgaaaccccg tctctactaa aaatacaaaa attagctggg840catggtggcc tgtgcctgtg atcccagcta ctcgggaagc agagacatga gaattgcttg900aacctaggag gtggaggttg cagtgagtgg agattgtgcc actgcacgcc aacctgggtg960acagagcgag acttcatctc aaaaataaaa taaaataaaa ataaacagga aaaatctggt1020caaatgcccc ttgttcttct tcaacagata catagtgagt tgtgtaaaaa aggagttgga1080aaaggaatat gtagattcaa agtgacttaa agaatagaaa aaaaatttgt tttaaaaaat1140ggccaagact aaatcatagt gtctagggag gtacacctga ataataaaac tataaagaaa1200tacaaaatat ggttactact aagaatagtc tgttgccagt agtacacaga atgagcactc1260aaattataac agaagcattt tggtattcat aaatgttctt tttttaaaaa agaacacaat1320cgaaattata ggctgtaagt actgatttta attgtagtga atgtgaaagt gttgttaatg1380aaaatataaa gaatatttgt taaagtgtgg acctagccag gaatactagg tagaaaaggt1440aactctttaa aaacattttt ttaattgtga agttaattta ttgtcacttt gtttgatatt1500tattattaga gtccctaggt taattctgtt tttattgctt ttcagaataa ttaagaccta1560aatcttctgc cgaattctgt ttggtttcct tatttctttt gccatgttct ttcattccac1620aaatgttatt gagcacttcc agtgtaccaa gccttgtgtt tactgctttg atgataaatg1680caataaggta atgctgcttt taaggatcct tcaggatagg ctcttgtagc agtaaggact1740
tagtattttt gctatagaag tgtatggaga gctatctatg gtgcaataac tgtggaaata1800cagtttttat tctatttggt tcccatatac attgagtcct cctttggtgg gaatttgatc1860aggttggtct cagttgaatc ctggctgcat atgcctcagt aaggaagaag gcctagggga1920ctgtggaaag cctggtggtg gtcctggaag gcttgagaat acctggagct ggaagctcct1980tgctcattgg tgaccttttt catatgcagc agagctcttg gcattcctag catactacct2040tgaaaggact gtgtcttgcc tcctagaaat tctggacttg gtagaatcat ttgtttatgt2100tattttaaaa agaaaaaaaa ctctgaaatg tactttttgg aagaaaaatg aacttgtttt2160tggacttttc tgtgtgttgt ttctttaatt gaaaattctg tctggagatt gattttcaac2220ccccttcctt tccctctagt tttaaattgt aacattgctt tccaagcatt tcaaaaaaaa2280aaaaaaaaa2289<210>27<211>1694<212>DNA<213>人<400>27atgccatggc tagtccaggg aaagataact atagaatgaa aagttataag aataaagccc60taaatcctca agagatgcgt agacgaagag aagaagaagg aatacagctt agaaaacaaa120aaagagaaga acagttgttc aaacgcagaa atgtctattt gcccagaaat gatgaatcta180tgcttgaaag tcctatacag gattcagata ttagttccac tgtacccatt ccagaggaag240gagttgttac tacagatatg gttcaaatga ttttttctaa taatgctgat caacagctaa300cagcaacaca gaaatttaga aagctgcttt ctaaagaacc taatccacca atagatcaag360ttatacagaa accaggagtt gtacagagat ttgtgaaatt tcttgaaaga aatgaaaatt420gcactttaca atttgaagct gcatgggcat taacaaatat agcatctgga acttttctgc480
ataccaaggt agtgattgaa actggggctg ttccgatttt tatcaaactt cttaattctg540aacatgaaga tgttcaggaa caggctgttt gggcacttgg taatattgct ggtgacaatg600cagaatgcag agattttgtt ttgaattgtg aaatacttcc acctctttta gagttattaa660caaattcaaa cagactcaca acaacaagaa atgccgtgtg ggccctctca aatttatgta720gaggcaaaaa ccctcctcca aactttagta aggtttcacc ttgcttaaat gtcctgtcac780gactgttgtt tagcagtgac ccagatgtgt tagcagacgt gtgttgggcc ctttcttatc840tttccgatgg acccaatgat aaaattcaag cagtcattga ttctggagtc tgtcgaagat900tggtggaact tttgatgcac aatgattata aagttgtatc acctgcatta agggcagttg960gtaatattgt gactggtgat gatattcaaa cacaggtaat tttgaattgt tctgcattac1020cctgtctctt acatttattg agtagcccaa aggagtcaat tagaaaagaa gcctgctgga1080ctgtttctaa catcactgct ggaaatagag ctcagattca ggctgttata gatgcaaata1140tttttcctgt tttgattgag attcttcaga aagcagagtt tcgtaccaga aaagaagcag1200cttgggctat aactaatgca acatcaggag gtactccaga gcaaataagg tatttggtag1260ctttaggctg cattaaacca ctttgtgatc ttttgactgt tatggactcc aaaatagtcc1320aagtggcttt aaatggactt gaaaatattt tacgtcttgg agaacaagaa tctaagcaga1380atggaatagg cattaatcca tactgtgctc tcattgaaga agcatatggt ctggataaaa1440ttgagttttt gcaaagccat gaaaatcagg aaatttacca gaaggcattt gatctgattg1500aacattactt tggtgtagaa gaagatgacc ccagcattgt acctcaggtg gatgaaaacc1560aacaacagtt tatatttcag cagcaggaag caccaatgga tggatttcaa ctttaactta1620ctggaggaaa aaaaatttat ggctaaaaag ggtagcttca ggtaactcct ctttgttgcc1680aatgtaagga actg 1694<210>28
<211>4756<212>DNA<213>人<400>28gcgacgctca cgaacgatca gagctgcggg cgacgcaacg aagcccggag gccgcaggct60gcgcgctccc tcgcagcagc cgggcgggca aaagccccca gtcctcggcc cccgcgcaag120cgacgccggg aaatgcccac atccgggaaa cctgcagcgg agtgcggcgg cggcgacact180gagtggaagg caaaatggcg gcggcggcgg cggtggcctg gtgttaaggg gagagccagg240tccttacgac ccctgggacg ggccgcgctg gcccgcggca gcccccccgt tcgtctcccc300gctctgcccc accagggata cttggggttg ctgggacgga ctctggccgc ctcagcgtcc360gccctcaggc ccgtggccgc tgtccaggag ctctgctctc ccctccagag ttaattattt420atattgtaaa gaattttaac agtcctgggg acttccttga aggatcattt tcacttttgc480tcagaagaaa gctctggatc tatcaaataa agaagtcctt cgtgtgggct acatatatag540atgttttcat gaagaggagt gaaaagccag aaggatatag acaaatgagg cctaagacct600ttcctgccag taactatact gtcagtagcc ggcaaatgtt acaagaaatt cgggaatccc660ttaggaattt atctaaacca tctgatgctg ctaaggctga gcataacatg agtaaaatgt720caaccgaaga tcctcgacaa gtcagaaatc cacccaaatt tgggacgcat cataaagcct780tgcaggaaat tcgaaactct ctgcttccat ttgcaaatga aacaaattct tctcggagta840cttcagaagt taatccacaa atgcttcaag acttgcaagc tgctggattt gatgaggata900tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca960ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac1020ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct1080ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg1140tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat1200
ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac1260caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc1320caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt1380ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag1440agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga1500gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat1560ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga1620tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc1680tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt1740cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata1800acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt1860ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca1920taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta1980attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg2040tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt2100cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt2160caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac2220cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta2280agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg2340aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta2400ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag2460catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc2520
tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc2580aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg2640ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg2700aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa2760agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg2820ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt2880tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg2940gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa3000gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc3060gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg3120attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg3180aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag3240ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg3300cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg3360ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa3420cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca3480gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca3540agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg3600acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa3660attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa3720atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat3780ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg3840
aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca3900caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt3960aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt4020atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat4080tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa4140aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa4200agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata4260tgctaaataa ttttaaaata caagagtttt tgaaattttt ttgaaagaca gttttagttt4320tatcttgctt taaccaaata tgaaacatac cccctatttt acagagctct tttttcccct4380cataaccttg tttttggtag aaaataagct agagaaatta agccatcgtg ttggtgagtg4440ttcctaggct aatgataatc tgtataattc acatcctgaa actaaggaat acagggttga4500aaaaatatta atatgtttgt cagaaggaaa aataatgcat ttattttccc ccccaccccc4560cgccccatgg aatatttaat ctatttaatc ttcttgcatt tatttctcaa gaattactgg4620ctttaaaaga agccaaagca ctactagctt tttttccata ttggtatttt tgatgctgct4680tccaatttta aaagggaaca aagctgccat aaatcgaaat gttcaatact aaaagctaaa4740atatttctca ccatcg4756<210>29<211>2306<212>DNA<213>人<400>29ggaggcagga gaatcgcttg aaccctggag gcagaggttg cagtaagccg agatcgcgcc60acagcactcc agtctgggcg acaaagcgag actccgtctc aaaaaacaaa aacaaaaaca120
aaaaacaaac aaaaaaccat aaattcacag ttcagtggca attttaaatg gaaagacacg180ccttattcac tatgatgctt ttattgctaa ttcattcagt gaagaggaat tatgcaaggt240ttaaaatggc ttgcctgtcc tggtatatcc aaaactctta attcagaaga ttcatctatt300tctccaagag aagaagctcg tggtggggct ggaggaggtt caggctcaag atcaaagtcc360aatttggtta ctgtagaatc gcttatagaa gataaagtaa ctcaccaaaa cagtaataga420aagtctgtat tttaaacagc tttaaaatta aagcaaacaa tttacttttt aagtaaacag480aacactactt tcaaaatact acttgggaaa aaagcaagac tcagtacacc tgctataatc540agtacgtaag aatgtcccaa taactttgta taagagatgc ttaaaatctc agacacatac600ctagctggag gtgctagttg agggatgcgt acatcaacca ctggcactgt agtaggcaca660ggagcttgag ggctgaaggt gccagaatga tttactgtag gaatagctct tcttactagc720cttccccaag tggcaatatt aatattcatt tgaggagctc tgagaaatgt tttgccttgt780tgctttgaaa aaattttctt ttgtctttga agttttggtc ttctttcaat aactggatta840aaaaaggtaa cctctgcaaa taaagtaccc tgtggttcca aatagagaca catgccatgc900cgttggttgt ctaaaaaatc ttctaacctc agaaaatttt acagcacaca gagaccgcca960atcacgccaa taaactgaaa tttccagttc acgtgacctg tccagttcca gtgtaaactt1020ctggtcccat gactgattgg aaatgggttt ccagctagtt tggccaacca cagtattatc1080gagcttcaaa acagcacaga catcattgga caagtcatcg gtttttagaa gatttcgact1140acttccgctt ttacttttac tcgttctgct catgaaagat gatctggttt cacttggact1200ccaaccaggc agtgcaactg atgttgcttt tgaccgtcca gggacattct ctaggatatc1260ttggcagccc ataagacgaa cttccaaagt acctgttagt gctgctggtt tggatagtgt1320actatattga ttttgcgtag atatcatact ttgacgtgga cttagtgttg gtgatgcagc1380aacaagtgaa agttcttcaa taataatcct gcttttggga tgattcttgg ggacttcgtt1440
taatctttgc tctaatgaat actttaaaag gtccaacttc tgacttgatt cattaaatct1500tgcttgagct tctgaaagtg cttttctgtc tgttactttt cctgagccaa gtaatttcat1560tacattcttt gcaccttctg ctactgcaaa ctctatccta aaatgatgcc ttaattcttc1620catccgaagt tcaagaggac ttatcacagg ttttgcatta tcaaaagcca attcattagt1680ctggactgcc tgaagaatct gcattcgtat gacttctatt tttgtcttgc tgtcctggag1740cagttgctga gctgtaccat ggagtttccg atcctttgaa gatccatttg aatacatctg1800tatcatattc tctgcacctt gttttacttt aagttctata tccaattgtt tttgtagggc1860cttcaatcta ttggtgctag tagaacaacg agggtcatta tttggagtat ctggagtcct1920tgggcaatct gtaatatctt ctggatctga tacaacaata tgtgcattta attcctgcag1980cttgtgatgt agttcttcta atttttattt gattttttca aaatgttgtc tacataagcc2040aaactttttt tatctgttgt gactttcctc agattttcag ctccttcttt gattttcagt2100tctttcctta tttctctctt aattcgatcc ttgatatcat ccaatttctg ctgcaccatt2160gtatctgaaa agtctaattt ttgaacagca ctcacattct cagaaaacgg aagacttcgg2220gaatccccct gcagttccgt gagcagaatc tccccccgtt cggggttgga cgccattgcg2280ctccggtatg gactccgcac ctggac 2306<210>30<211>1842<212>DNA<213>人<400>30ccacagtggc gccggcagag caggagtggc tggaggagct gtggttggag caggaggtgg60cacggcaggg ctggagggct ccctatgagt ggcggagacg gcccaggagg cgctggagca120acagctccca caccgcacca agcggtggct gcaggagctc gcccatcgcc cctgcgctgc180tcggaccgcg gccacagccg gactggcggg tacggcggcg acagacggat tggccgagag240
tcccagtccg cagagtagcc ccggcctcga ggcggtggcg tcccggtcct ctccgtccag300gagccaggac aggtgtcgcg cggcggggct ccagggaccg cgcctgaggc cggctgcccg360cccgtcccgc cccgccccgc cgcccgccgc ccgccgagcc cagcctcctt gccgtcgggg420cgtccccagg ccctgggtcg gccgcggagc cgatgcgcgc ccgctgagcg ccccagctga480gcgcccccgg cctgccatga ccgcgctccc cggcccgctc tggctcctgg gcctggcgct540atgcgcgctg ggcgggggcg gccccggcct gcgacccccg cccggctgtc cccagcgacg600tctgggcgcg cgcgagcgcc gggacgtgca gcgcgagatc ctggcggtgc tcgggctgcc660tgggcggccc cggccccgcg cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct720cttcatgctg gacctgtacc acgccatggc cggcgacgac gacgaggacg gcgcgcccgc780ggagcggcgc ctgggccgcg ccgacctggt catgagcttc gttaacatgg tggagcgaga840ccgtgccctg ggccaccagg agccccattg gaaggagttc cgctttgacc tgacccagat900cccggctggg gaggcggtca cagctgcgga gttccggatt tacaaggtgc ccagcatcca960cctgctcaac aggaccctcc acgtcagcat gttccaggtg gtccaggagc agtccaacag1020ggagtctgac ttgttctttt tggatcttca gacgctccga gctggagacg agggctggct1080ggtgctggat gtcacagcag ccagtgactg ctggttgctg aagcgtcaca aggacctggg1140actccgcctc tatgtggaga ctgaggacgg gcacagcgtg gatcctggcc tggccggcct1200gctgggtcaa cgggccccac gctcccaaca gcctttcgtg gtcactttct tcagggccag1260tccgagtccc atccgcaccc ctcgggcagt gaggccactg aggaggaggc agccgaagaa1320aagcaacgag ctgccgcagg ccaaccgact cccagggatc tttgatgacg tccacggctc1380ccacggccgg caggtctgcc gtcggcacga gctctacgtc agcttccagg acctcggctg1440gctggactgg gtcatcgctc cccaaggcta ctcggcctat tactgtgagg gggagtgctc1500cttcccactg gactcctgca tgaatgccac caaccacgcc atcctgcagt ccctggtgca1560
cctgatgaag ccaaacgcag tccccaaggc gtgctgtgca cccaccaagc tgagcgccac1620ctctgtgctc tactatgaca gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt1680ggtcaaggcc tgcggctgcc actgagtcag cccgcccagc cctactgcag ccacccttct1740catctggatc gggccctgca gaggcagaaa acccttaaat gctgtcacag ctcaagcagg1800agtgtcaggg gccctcactc tctgtgccta cttcctgtca gg 1842<210>31<211>2524<212>DNA<213>人<400>31attggctgaa ggcacttccg ttgagcatct agacgtttcc ttggctcttc tggcgccaaa60atgtcgttcg tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg120gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta180gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag240atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc300actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga360ggtgaggctt tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct420gatggaaagt gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa480ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc540acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt600ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca660gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt720ggaaatgctg ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc780
aaaatgaatg gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc840ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat900gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc960cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag1020agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc1080aggatgtact tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt1140aaatccacaa caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc1200caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg1260agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct1320agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg1380gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag1440aagagaggac ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa1500atggtggaag atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc1560attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt1620ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg1680gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc1740taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca1800ccgctctttg accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa1860gatggtccca aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag1920atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc1980cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta2040gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc2100
gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag2160cagagtgaag tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc2220tataaagcct tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc2280ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta aatatggtta2340tttatgcact gtgggatgtg ttcttctttc tctgtattcc gatacaaagt gttgtatcaa2400agtgtgatat acaaagtgta ccaacataag tgttggtagc acttaagact tatacttgcc2460ttctgatagt attcctttat acacagtgga ttgattataa ataaatagat gtgtcttaac2520ataa 2524<210>32<211>158980<212>DNA<213>人<400>32gatcagtcta aagagaattg gcaatatcta cacctgtaaa gtgtaaaatt aggaaaacaa60ctcaaaattg ttataaatgt acaataaata ctgctcattc aataacggct aacaacagac120tcattgttga aactgcaagt gttgaggatt ttagtaactt gattatgtaa atgagataaa180gccttgttta tagatataca aatttaacag gtaattatta atgttttgtt gtatatatga240gtgtgctcct gtgtgatgta aaaacagaga catgtttgag aaactatgaa taccttgtac300aaacaattta gttgctttat cttagaattt tttgttttac tgtgccttct ttcggctcaa360aaggaattat tgcctaagtc agtgattatc tgggcaacag aattaatgtt ctagctacag420cattgcacta tttcacagga tctattgatt actttttaaa aatttttctc atctgtcctg480ttctcattat tctactatta ttattttagt ttgggcctta tttaacaatt aactaaataa540ttacatttgc ccccaaatgg tatccctgcc atctatattc tctctctctc cctctccact600catcacctgt ctaccaatat atttattgtc tactactttc catgttcctc attaatttct660
ggtattagta aactgatacc aaatgttgcc tcccttaaga aactgacagc ctagtccggt720ttactactgt tccgtagaac cttgcatctt tcttctttaa aaatctttaa cacctttcag780tggcttttag aaaagggttc acatttttca gagcttttga cactctttac cttttgacac840aatatattat tattatttgg gggaacagca ggaaccaggg atgattaatt tcctacaatg900tgcagggcag ttctatataa caaaattatt tgtcccacat tttacatgac tttcaaatgc960cccacaaaat gttcaaagac atgagaatct catctgaact cagagctcaa ctctgttttt1020ttataatgta caaagctttg attttattta ttttttggaa aagctttgat tttatttatt1080ttttggaatc attttaatat gcactgattt tgatgctaat ttcaacccac ctaattcctt1140gcccaactga tagatccatc ttctattttt aaactttagg aagtagaata ggtcagtgaa1200gagcattgtg ataaaaaccc agggtattcc cacactgttg ccctctgaac aattttttag1260gatgtgagtg tgtgtgtgtg tttgtgcatg tgtgtgtgtg aaggcgactt tcgcttggat1320aggatgccac tccataaaac agttagagaa taaaataaaa agagtacagt tggagtcctg1380ttcttgctct gcttaccccc attatcttgt gacacacagt acctgttcca aatccccact1440cagaattctt aacccagtat ctcaggagta aattctggca ctaaaggggt tctttccttc1500tgaggagcta agaaaaacag atggagaaaa tctgacctca agcagatgtg tctctgcccc1560tcattctcca aattcttggg agagtgttac tcagtcttac tgcacagtga cattatcaat1620ggaactttaa gaaatactaa tgcctaggtc tcattctaat ggcttctgat ttaattgctt1680tagggtatgc cctggtgatt ctgaaatggt tctctcacaa cctaggacta gggacttata1740atctaaggtg tatgtcctcc aaatgctgat tctacatagg gcagtaaaga gtggaaagtg1800aagacttgac ctgtgatttt ggtggtgggg aagagaaagg ctattttggt atttctggct1860ctttatctta agagtcatca atcctctact tgcactgtca gacacattgg gctgacacat1920tcgaaaatac acattgcctg accgtgtggc tgatactcct agagaagcgg tttctaaatt1980
ttatagccca ttggaatcac ttggacatct ttaacaaaca ctgatacccg gctcctactc2040ctagacatgc cgatttaatt tctatggagt ggcacctggc tttaggattt ttaaaaagtt2100gtgcagcttg ttctaatgag cagcaaagat tgggacccag tcccagtgaa aaaaagctcg2160tagaacaata caacaggaca tttaaggagc acagccattt caaaacaata ttctgttaaa2220aattatagat gtccatatag ctgaaatagt aagacagatt gtgaatttaa aactagggaa2280gatatttgaa agattaaaaa aaggagtgga tagccaaatt cataccatat acacatatga2340aggtttccag gtcagaagac caacaaagaa tctaaagtaa gacagacatt aggtttttca2400acagtaaata ctatatgcaa gaagatgaca aagggatatt ttataagttc tgaaggaaaa2460taatttaaaa tatagaattt cccatcaagc caaacagtct tcaaatatgt cagcataagg2520aaaggttttg gaagcataga aagtcccaag aggtttgcca tgcagaaact cacatagaca2580acagttttgg ataaagtcag aggaaagaaa aatccaagag atgctgcaaa agatatctgt2640ataaaaggtg attgaatata ttggcaaagt ttgttcttgt cttggccatt tatttaaagt2700caaataaaaa gaggaaaaat attcataata atccacaatt aaaagtctgg aaaaaaaaag2760tcatggggat ttttgtggag aactaaggaa cttaagaatt ggccaatttc ttgccttaat2820agggagtaac ttttttttta ggagacagca ttaaaaagaa atagaaaagg taaacataaa2880caaaaaataa gttaaggttg gagaaacatg tccaagtata ccagtaataa tgattaatgt2940aagtagacta gattcaccaa tgtaaagtcc aatattgaaa aactgagtat taaaaaaagc3000cagatacata ttgtttaaaa agtatgtgga cttcacttgt gcccaacatg gagcaacaga3060aaccagattt acccttatat ctgaaacaac tgagaaactg ggtaaatata ggaaagaaca3120gctttcaagg cattggcatc aagcaacaca gaaccgtgat ccctggcaga cagcaaacaa3180atgaggtgag ccctctgatt ttactcaaga gaatttccag gccatcagaa ggggaaaccc3240aagtggagac cagtggactc cctgagtgaa ggagatgaag ctaagaatac aggaagaaga3300
atgcagctaa ggttaacatg gcaactcaag caccaaagga gagagagcca cacagagata3360aaactctgga caactacaga aaaattgccc tttaatattc agcaaattac tgatcagtgc3420atgtatttga aggaaaaaac ctcaatcata attgagggat caattatcaa ctacccaaaa3480tgattaaagg aaacaggact cagcactcac ccagaatggg ggaaagtgct tgttccccac3540gaggcagact ggtaaaccat acaattcaca gggctttggg taagggatct tgtcttggca3600gtggggagta attaacccta gaccaaacat ggtgctgttc ttgcttaata agtcttaaaa3660gcaggacacc aaatggtcaa actgtttcaa gtaacttaac tgcatttcaa aaaaactcat3720gatactttta gaatacaaaa tattcaacat ccaacaaggt agaattaacg attcctggct3780tctaatagca tgaacccagg aggcagagct tgcagtgagc agagattgcg ccactgcact3840ccagcctgga caacagagtg agactccatc tcaaaaaaaa aaaaaaaatc agttcatcaa3900aattgatcaa tcaatcagaa ctgataaacc aatcagaatg gataaagatg tagtaattac3960cagacaagaa cattaaaata cttaaactct acatgctaaa aatagcagaa gaaagattga4020acattatatt aagagaactg gaaaatataa gagaaccaaa tagaactttt agggatgaaa4080actacagtgt cagagatgaa aaacacacaa agtagtatta acagcagacc aagcactgaa4140gaaaaaacca aaagtttagt gaatttatag gcttagcaat ataaattatc caaaatgaaa4200gaagtagaaa aaaagattta aaaagaaaat gaaccgtgtg ttagttagct ctgagacaat4260ttcaagtttc ctaatgcaca tgtaattgta gtctctgaag gagcaggagc agagaaatgg4320ttgaagaaac aatggcctaa aattttccaa atctaatgaa agctgcaaac ccacaagttc4380aaaggaaagc aatgaactcg aagtataaga gacataaacc tggccgggca cagtggctca4440cacctgtaat cccagcactt tgggaggctg aggggggtgg atcatttgag gtcaggagtt4500cgagaccagc ctcacaaaca tggtgaaact ttgtctctac taaaatacaa aaattagctg4560gacctggtgg cggtcacctg taatcccagc tactcgggac gctgaggcag gagaatcgct4620
tgaacccggg aggcggaggt tgcagtgagc caagatcttg ccactgcact ccagcctggg4680tgacagagtg agactctatc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaggcctaa4740acctacatat aattaacttg cttaaagtaa gtgataaaga gaaaatctta aaagaaatca4800gagcaaaaaa aagatatcac aactgagaaa caaagataag gatgctagga gactttgcac4860tggcaaatct gagaggatag tagagcagca tcattaaaga attatgggaa aaagaaacgt4920gtgcaccagg tgttctatga ttagcaaaaa tatatttcaa aaataatgtg aaaatacaga4980tttttcagat tatctagtca caagaatgaa gaaaaccaca aataacactg taggtacata5040taaaataatt tttcttctca tcagtatctc ttcaaaagat aattgatggt ttgaaaagtt5100ataccatgct tttgggggat ttataacata gccataatta aaatgcatgt catcaattgc5160ataaaggtag agagggaaca catggaaata taagagcata agagtgttat atgtgaagtg5220gtaaaatatt gctggaagta ggctctaata agatagaaaa aggctcagct aaaacataat5280aacaatcaaa ggttggatat aatgtcgact aagaaaagta ggtgtaggta tgttaggacc5340agataaaata acattgaatc attagagata aagaggagca caccataatg atataggctt5400ttaaaacatg cttatactta atacaagagt ttccaattat atgaagcaaa agtccgcaaa5460agtccattaa aatgctatag aaataaactg ataaatccaa catcaaaatg agaaatttta5520acacacccct ttaattttta gttggtcaaa gtgaagaaaa taaaagccag tatataaaag5580agatgaaaat aaaatcaaca aagatgactt aatcaacaca cgtagaattc tgcataccac5640aattgcagaa tacacattgt tctattgaag acacagaaag catataatag gcccttaaaa5700agccatgctc tttcacaaga caattaagtt aaaagttggt aacaaaaaca ataaattact5760agaaattaag aacatttcaa gaattttcta agcttgtagc ttcggtgcaa ataaagcata5820ttttgtttga aattttataa acagtgtttc accattttgg caaatgacat cacaatgtca5880cattaactat gttaacagtg catgaattag ggtgaggcaa gtgaggcaac caaggtgcaa5940
aattcaagga atcaaccacc cgtggaatca tgtaaatacc tgtttacgta tttttgtccc6000aggagcttcc taggtttacc ccagttctgg ccctggtatt tgagtcatct caacaagtca6060cttgtgttgg tctacacttg tagctgttgc atataaatat gctaaatagg agattcgtgg6120ctcattttta acagatttag aacaccatta aattaacagt gaaacagcaa agtcagggat6180gctattacat ctcactagta aaggtaactt taaaaatatt tcatattttt taacctacgt6240atttttgatt tattctggaa tccattgata aattaatctg ctgtgaaaag agcagagtga6300aattatttat ataatttgga gttggcaatc tttttcaaac taactcagat aaatgtcctg6360caggataatt ttacaatttc tctacagatt cttattttat agttgggctg tttgtatatt6420ttatatttgc tcttaatcca tcctttcttc cccatcttca atagatatac ttcaagattt6480cagcaccaaa gcctaatata tgctttgaca agtagcaggc tttccagaga tgagatatgc6540cttctgtcat gatatgttac tgtctcattc catgcagtga cataaggaaa tattttgact6600ttataaagct cagctcattt gtgagggtat tatatttcat tttccgcccc tatgtcactt6660tgtcatttgt cttgacttat cacccctact tcaattaagg ttatgtccca ctttctttta6720tcacagaagt aatactagtc tgttttactt attgcatcaa ttctttttat tgctgctgta6780acaaatattc acaaacttgg cttgaaagag caaacattta tgacctgata gttctacagt6840tgagaagtct gacacaggtc tcactgggct aaaatcaagg ttttgacagg acaatgttcc6900tttctagagg ctctagggat gaatctgttt cctggtgttt cctctagagg ctgccagcat6960gccttaatgc gtggcctcct ccatccacaa agccagcaaa ggtaagcggt gcccttctct7020catctgcagc actctcacct ggcttctctc tccgcatttc tttctctggc tctgggtctc7080tcttccactt ttaatgatcc tcgtgattac atggggccca cccagacaat ccagaaaaat7140ctttcttttt aaggtcagcc aattaacaat cttaattcta cctgtgcaac cttaaattct7200ctttggcagg taacataata tattcacatg ttccaaggat tcagatgtgg atattttttg7260
gtaggggcat tattctgcct gtaatatatt ttttcgaaca ccagttgttg ttctagtgtt7320catgcccatg tttgttgttt cattttccta ggcttctaca aaatgagttc acctcacttg7380tcacaaattg tatcttattc atttcctgta ggcacatgca tttgaaactt ttatacatct7440tctggtgtat acaagtcctt acatgatgaa atgtaaatta ttttaaatta ttttcctatt7500atggctctaa aattgtatgg ttggggcatc ctccctccct cctttccccc cttccttgct7560tcctcctttg aaattatgtg tgttggtagg ttgcattaat catcagtttt atttcagggt7620cataaaagga gtgtaacaaa ataagtataa taaaaaagga atgttggata tgttatgact7680gagaggcacc ttagcagaag ccaaaagttg actccttgga ctataagaga agcctcttca7740aggaaaattg tagtgctctg tccataaaga actgtgcaaa cactacctac ccccacctcg7800aaatactttg gatattcagg cagagccaga gctactgtca gtggaaatat tgaccttagt7860atgtcattta attacctgag ctctatcaag aaccttgtag acctgtgagc agaatatgaa7920atagagctta cctcctatag tttgataaga gctccacaga gccacagtgg aaaattaagc7980aaattcctag acaatttcaa taaaaatggt ctatttttaa agttattcta aataaaaatt8040aaaaatttgt gttaacctta ttttggttac taaatgataa tgaacatacc ttttcaaaat8100taaaataaag tttacattct tcttgtgggg acacttttaa tttctgctta gatgatttat8160aatggaattc atcaccaaaa gataatttaa ttatatgacg gtagtttaca tataaattag8220aaagttttag gctgggcaca gtggctcatg cctgtaatcc cagctctttg ggaggccaag8280gtgggtggat catttgaggt caggagtttg agatcagcct ggccaacatg atgaaacccc8340gcctctacta aaaatacaaa aattagccgg gtgtggtggc atgtgcctgt agtcccagct8400acttgaaggg aggctgaggc aggagaatca cttgagcaca ggaggtggag gctgcagtga8460gccgaaatca caccactacg ctccaacctg ggtgacaggg ggagactctt tctcaaaaaa8520aaaaaaaaga aagttttagg tttaaatttt tttttttctt cttggtgaga cggagtctct8580
ctctaacgcc caggctggag tgcagtggca cgatctcggc tcactgcaag ctccgcctcc8640cgggttcacg ccattctcct gcctcagcct cccaagcagc tgggactaca ggcgccggcc8700accactccca gctaattttt tgtactttta gtagagaggg ggtttcaccg tgttaccatg8760gtctcgatct cctgacttcg tgatccacct gccttggcct ccgaaagtgc tgggattaca8820ggcgtgagcc accacgcctg gccttaattt tttttttaat tctttacatt ttccaatgga8880gtaattatat ccctgagtta caagtcaaat gcgagcctcc atcagatttc ttggctccct8940tcctaaagac aatagagcaa ctcattactc tgcttcagaa tctttctccc aacctttagg9000cttctctagc tatgtagtga tgggaggaaa ggtggtggta gggtggggtt gggcacaaat9060tcctattcct ttcatgactg ttttacagtt gcttccttgt agggacatgc cacagaaaga9120agacactaca ggatccagaa atacttaaat aagataattt gtggaaatct tatcccttaa9180atatcttcag ggagaagtat ccttagcaac ttcttctttc tataggcaaa tcatggctgg9240gtaggtggtg gtcttctgct tccaagaaac cggcaatcaa caactcaagt tgcctcactt9300ctcatataca agtcccagca agagcctaga tgaattcact aatgcacttc atcctcctgc9360cctcttcctg gttcaggcaa taataatcat agatcgccat tgtcaattct tttttgttag9420acatgatgct ttttaacatt atttcatcta atgctcacag aatctctatg tggttagaaa9480tactattact ttacaaatga aagaacgcaa aataattgag ggatgtagat aactctctcg9540agataatgca gtaaacaaag ggtgatatca ttttgctgtg tccccaccca aatctcatct9600tgaattgtag ctcccataat tccacgtgtt gtaggaggga cctggtagga gataattaga9660tcctgggggt ggtttcccct atactgttct tgtggtagtg aataagtctt aggagacctg9720attgttttat aggggttttc ctcttttgct tggctctcat tttctctctt gtctgctgcc9780atgtaagatg tgcctttcac ctttggccat gattgtgagg tctttccagc catgtggaac9840tgtgcatcca ttaagcctct ttttctttat aaattaccct gtctcgggta tgcctttatc9900
agcaatgtga aaatggacta atataaatgg cagggcccat aaatgaactc tattctgttt9960aacaccagtg tgtatcgttc attcattcaa caaaacaatt cagttactta atatgtgcca10020agcagtgagt taggtattga aaaagcaatg attaaaaaga cagaaggtac ctttctcctg10080ggaggttaaa ttttactgaa ggaaatagag ggaaccaagg aaataaaatt aagtagttac10140aatatgtaat aattttgatg aagaaatcac atagggatcc ccaggagggc agaaaggtat10200ttcaagcaga aagttcaaga aaggtctctc tgagtaatga ccatttaagc taagtcttta10260ggaagacaaa gggtgtggcc tggaaaggct ggtgggggca gaaagagcat tccagagatg10320cacaccagcc agtgcagagg atgactcaca cgcagtttgg tgaagactga aggggtcata10380aaagtaaagc attttttgga gtgtaatttg gcaatagcca tccacatttt aagtacattt10440aaattttctt tgggtgcagc aatttctttt cttgtgggct ttaaaataag tgttgcatat10500gtgaactaag ccacacaatc aggtagacat tacactttcc taagggacag agagacatgg10560gatctcaggt ttttcttgct gttttctttt tttaatgttt tcttcctctt cttattttaa10620tcttctgggc tataagttat aatgctcctt ttagactttt tttttcctac cctgcaggca10680gtcacctgat agagaggttt cctggaatag taataggaaa ataatgcaca gcaaagctga10740cacaccacat gccgagctgt actgaaggca caatcataac ttttaataac gaaagtttct10800tttggtaaaa taatatcttt ccagctgtcc taacagatac taatgtgaaa tgctcccttg10860ggacaggacg gtggagagaa gtcacccccg ttccagaggg gcatgccctt ggctcagaac10920ctcagagcac taacataatg tagtactaag attgcagtga caccagtaaa acctgctctg10980taggactgca acaggctaca ttttttttat ttgtgctttt gttttcctgt aaatcacttt11040tgagtttctg tttctcaagt ctggaagcag caggtgtgta attttggcag aacttttccc11100agccattatc tagtggttta ttgtttattt agagtgtggg ggtgagttat aataaagaga11160ttggccctgt gggttaagac tgggcacatt tctatttaca gtcctaccag gtcttcacat11220
tctaggcaaa atgaaaggct aagccagtta tccagatagt tcaggccaaa aggtaaacac11280aaagagagga tgatttagtg ctgtcccacc tccggcttac gcttctgagg taacaaccac11340agggttctgc tttggtttgg caatggaaat ctgagttctc ctagctgtga cttgtgttag11400gaacgtagac tctgtccagc tcagtaggct gtgacataga aaatacatga agttaacttg11460ggcatagaga tagacatgat ccaattcccg gttcaaaact tatcccctat tgccttgttt11520cttttccttt tatatgctct tacatctcta gtgaagtttg ccatcagtat atttagttgt11580attaaaaatt ctccaggttc agttaatgcg gtcattttgg gtagactgtg acatacattt11640gcatggattt ggtctccctc cctccctccc tcccttcttg ccccgcttca ttgctctctt11700atttcttttc ttcctttctt actcccttcc ctcatcactt ccttcctttc ttccacattt11760atttaatgtc tataaccaga acccatgcta catatttgag aaacaaagtc aaacaaagca11820tacatttatt ttctaataaa ctaacagtgt agttgttggg gaaaaagaaa agtaaatgaa11880aaattataat attttggtta aaatatacat tggaagctgc tggaaaagaa ttcatgaaca11940caacttagtt gtttttagtt ttacaggaag tgaacctgat atacaattat tggtggtcta12000gaaatacaga tgaactggat aaaataattt tgaaaaagag gtttaatctt tctcactgaa12060aatccattac agtatggaac atatttattt cttctttgaa ttatatacat ttcctaacac12120ataatagatg cttaattaaa atgtttgaaa gaaaggagat gtaaatgtca caattttaaa12180aagtaatgat ttggctgggc atagtggctc gtgcctgtaa tctcagcact ttgggaggct12240gagatgcaag gatcgcttga gcccaggaat ttgggaccag cctgggcaac aaagtgagac12300ctcgtgtcta caaaaataaa agaataaaaa taaaaagtac ccaggcacag tggcccattc12360ctgtagtccc aggtactcag gaaactgagg caggaggatt gctctagcct cggaattgga12420ggctgtggta agctatgatc atgccactgc aatccagcct gggtgacaga gcaaggccca12480atctttaaaa aaaaaaaaaa aaagaacaga aaaaaaaaga aatgattctt ttttgtagag12540
agtatttaga aaacatttta tgccatgctt ttctgtatta gtgaggaaaa aactgaatat12600aatttacctt ttctttgaga actcaatcat cagtatgaac aatgattact taagtgaact12660ttaggtgttc aggcagagga agatgtaggg tatagggcca gtgggtagca acacgagcaa12720gtgcatcaca tattctttat tgaaatgatc tcatttgctg aatgcttgct tctagtttat12780ttttattgga tagtttcctt tctcacatat gtggaagaaa accaatgtat tgcttggccc12840ctagggaagt gtaatgtggc tattctttcc caatgtaaat catggaataa aaatccacag12900ccttctctca aattattttc ttaccctcca gaaaaattcc tttctctcct tgtcatttga12960tttctcaata acattcagat cattatctct ttttccaacc tgtcactatt aacatatcaa13020cttcaatata ttttctatat atttacacta tcatttattg aacaaatatt tattgaacac13080ctgctatgta tcagacattg ttctaagagt tgaaggtgca tcattaagca aaagtcagaa13140tccctaactt cacagagttt acaatacagt acatgtaact gaagtgtctc tctcactatc13200aagaatttgt gttcgtgtaa ttgggagggt tctttttctc tttctctttc tctctttctc13260gtttccttct tttcctttct ttctttcttt ctttgttttt ctttgtttct ctcttttttt13320ttttttgatg gagttttgct cttgttgccc aggctggagt gcaatggcac catcttggct13380cactgcaacc tccaccttcc aggttcaagt gattctcctg cctcagcctc ctgagtagct13440gggattacag gtgcctgcca ccatgcgcag ctaacttttg tatttttagt agagacatgg13500tttcaccatg ttggtcaggc tggtcttgaa ttcctgacct caggcgatcc gcctgccttg13560gcctccgaaa atgctgggat tacaggcgtg agccaccgtg cccggcccca gggctttttc13620aaagtgtatt tcataataac aagaatgcct attcattaaa ggttttataa gattttacag13680ttgacaatgc tcttttagag aatacattct cattggaatt tcacagtaac ttttaagata13740cataggatag gcgttattat tgtttttttg tactgtgcag atgcagaact tgggtttaga13800cagagtaaat tacttctcaa gatcccagag gtgtaagtag caaatacttg agtttagaat13860
atttaaaaat tccaaaactg ccttagtact tttaaatttg gaaaatattt ttatatttat13920tattttattt gttcttcaaa atgatctgtg tggtaattac tgattcctct ctaatcttcg13980tgcccgatga tgtggaattg ttgcattatc tgcccagatt tatctagctg gtaatggtag14040aactgaaaat ccaactatgt tcattgaaaa aatcaactgt ggaagctgaa cacaaatatt14100ttctttaatc tttctatatt cttataggca aatggaattt taaaaattta ttataaatat14160aatagagatt tttaaatgct ttataaatta atttcccatg aagttaattt ttctcataac14220attatatatt ctaaataaca cccaggtata cagtttgaac aatgaagtga cagtggcagg14280cagtaaaatc ataaaacaat tacctgacac attctgcttt tcagagtatt ttctacaatt14340ttcttaagtc aacctgtcat tcagacaagg tttaaaaaag tacatttcag cttccaaaat14400aaggttaaaa caactagaaa aacaaaacaa aacagagctc tagcacccct ccttgtatgt14460ataatacata tcttgtaaat acagagctgg aaatgtacat tatttttgac agatagagct14520ttcaatagtg agggttttat tacataaaag acagcaggaa tggtatatgc aaaagccgtt14580aaggtctccc ttttcttctt aaactcagca gtttgtgatt attactattt ggcaagcagg14640agtaaattgg accacaattt caacagcctc atagaagtat tccaggagac agtgttgata14700aatgagtcct agaatgccat ataattttcc tgcagtttca ttgtttgatg acttactttt14760catggataca ctctgccctc aggtttcatg tcctgctgcc aaatgtgaaa gctgtttgtc14820agaaatcaat gggttcaagt ggcccatcaa aagcttctgc ctttttgttg ataggaaaca14880ctttgtatag gaatctgctt tctggagaac tcattgctat cccttttgta tatacctgaa14940ccttgtcctg gctattatta tggtttcctt tgccagggga ttccccagtg aagggtgctc15000tgcctagtac tgcttgggtt actctcaaga tgacaacccc tccaatacag caatgactgc15060aaagctccta aggacaatag gattcagagt gtcttcttcc accaaaagct gagctaaata15120tagcctaaat atagcttttt gtattttgtt ctagggggtc attgatgtat ttacaataag15180
ggatagatag gaaattttca tatattgtga atctattatg tagcaggcac tgaggtgctt15240tccacatgct atcttcttaa attgtcatac gaaaactctc tataaattat gtattatccc15300cattttacag atgagcaatc tgctactcaa gaaagatagt atttgctgaa aggcaaataa15360cagaggtggg atttcaaatt cagttttatc ttactcccaa gatcatgctc tttctactta15420gcatttggtt aaccgggttt aatttgcact aagaccaaat gacagcaaaa gaatttctct15480tctgataggc aaactgacaa atcaaatcta tgcttttgaa aagtctgtta cttcccatga15540ctctgttttt tgtttgtttt ctattggtga gaatagagta catccagtca aaagtaagtc15600tggttaaggt gggattttga aagttgggtg gaagttaagt gtctgactag ttctgtccac15660tctttgtccc aaatctccat tgtgataggt aggatctcct cagtccaggt gtctgtatgt15720gacaataggt tagaaagatt cttgtacttg aggctttatg aagttgacca aaagacatta15780agaatgacta agtgggccag gtgtggtggc tcacacctgt aatcctggta ctttcagagg15840tcaaggtagg cggatcgctt gaggctagga gtttgagacc agcctggcca acatgaagaa15900atcctttctc tactaaaaaa tacaaaaatt agtcaggcgt ggtggcacat acctgtattc15960ccagctactc gggaggctga ggcatgagaa tcacttgaac ccgggaggtg gaggttgcag16020tgagctgaga ttgcaccaca gcactccaat ctgggtaaaa gagtgaggct ccatctaaaa16080aaaaaaaaag aacgactaac tgcacttagg aatggggact acattcattt tttctgtata16140gatactggag gtcttactag ggggttgtgg gattagtttc catatgtaat tgttctaaat16200gctttgcaac ctcacagttt tgagtctttt gatccctttg gtggtttatc caggctttac16260tacctggaac tgctgatact tggttccaga actcttatta gcaagatctt ggttagtcct16320tgcatctaca aatagctcaa gttcacctta agtagaaagc ttatcaatag atttctgtgg16380agactgcgga tccctccaat acacttgttg cttgatttat ttactagctc tcctctcttc16440ttggctttat ctcttactgt ttaagtagga gtttgttttc tcttttgttt gttttatttt16500
tggttaaagc agcagagaac ccagctcaaa ttggcttaaa aagtgaaagt gattaaagtt16560ttcgtggtat tgtgggcttc agcttttgat cagtgaagaa tctggctcta tttctctgct16620attcttttgg ctctggtttt gcagttgtag ctttgcccta agtctggctt gtcctatggt16680tataaaacgg ctgccagcaa cttctgaagt gacccgtttc tccattcagg tttatagaaa16740agaaagagag aattgcttct caagccattg aattgaagtt ctaaattttt ctctgaagga16800atcaatcatg gatgcttggg gtaaatgaga ttaacctgat ttattctaat caaggtgcac16860ccctggaaga ggtcaactct tccaacaaat gcacggtttc tatacaatga agagtgacaa16920agacttgttt ggaggtaatc aaaatgccca ccacatttca ctgaacctaa atattaaatt16980tgtctttact tttttgttgt ctgttttaca actagcaatg gagcagagaa agttggagga17040aggttattgg gatctttttg aagagcaaat cacattctca ttggtaacca tgatgaaaac17100atattttctt ccttgtgtgg gtctgagaca gtgtcataaa ctgctttcag caatagttag17160tatggtctaa ccgagtggtt ctcaatcagt tctaatcagt ggctccttct cccaggccag17220cagcatcagc atctcctgga aatgtttaga aatgcaaata ttgaaacaga aactctgggg17280atggggcaaa tctgagtttt aatgaacact gccattgatt ctgatcatgc tgaagtttag17340aaaccactgg tttgatgctt atttgcacta ttatactgtg gtttacatat gggcttgaca17400ggtccattta ctttcattta cttgctattt gagattttgt ctggccagac aactgagcct17460cagataaatt attttcttac taaattctgg taaataccaa taaaaccttg aatacaacca17520acataggaca gtcagttctg ctataatgat ttttaaaatg ggaatttgtt tcaatgcaat17580taatatattg ggaaacaaat ttagcataag gcaaattttg catttatttg tgcactactt17640catctgctag accaactagg tgaatgtagg aaccatacac agctgagctg agtctcatag17700gaacacataa aacacacaca cacctctcaa ggacaatcag tggcccagac ccatgcacat17760ctactattac aacttcttgt ccatttccac cacttcactg ttattaatac aagctgcaag17820
tcttccacaa actaacttca ggtggttttc aagataaagt gccatattgc ttgcagtatt17880tatgtatttt ttaatcattt aatgaatgta aaactatgct accatttatt agctgcttct17940ttttaaaaat gttccactga caaatgtttt gagtattatg ccccgaggcc tatgattttt18000attgtgttct tttgcattgc acagagaatt ttagcaatcc ctatgttgca ctaaagcaga18060attgagacta atttgagcaa aacttagcaa cttataactg ttacaatcct tatttcaggg18120caaacttttc attttataat cataattatt ttgtttcctc ttgagtagca cacacacaca18180cacacacaaa tctaaggtgt tcactatcac agaataatag cctttaaaat gtttaccagt18240tttcatattg atatattttg tttgactctg tcattccggg ctttaagtac taaaatatat18300tagtcttttt cagaaaacat tccaagaaaa aagttgaatt cctacctagt ttcctctctc18360tttgataacc tattgtcata gtaatataca aatacctgaa aattgcccag attattcttt18420tcttcttgga acacagattt gttgataagt gccaaaggat tttttacaaa aacatgagaa18480gtttgacatc acagtaagat ttaaaaggaa aggctgttta ttgttattat catcattgct18540actactattt ccgttagtat atatttcttt gtcttatttg tccttttcca aaagattttt18600gttcttatat ttttaattag ctctttaaag aaatcaagaa ctgcttgttg attatagaca18660tccttattgt ataaagaggg agaagttctt tggtaattag ctgtgtatag gttctgttca18720aacaattggc tcaagtgagg ttgtacagaa agaactcttg tattttctta tttttcagta18780tattctccac tccatcacac ctctttttcc aaagatgcag tgcaaagaaa gtataatctc18840tggagtaatt aaagctcagt gaggaaatga tatcacctga tggccctatg aagcattcag18900caataaaagg tgagttgccc aaaatgcatt taccctgaac aggaatacaa tgaaactacc18960aagttttatc tttataatga ttcgtggctt attattttgt tgtttgtata tgttctgttt19020cccacatcag tgttgtctta cattattatc tgtcttaact tagactctgt tttctaaatt19080gctctgtgca attaaatgct ttgtgatcat aataaaaagc atcatgataa cttttagact19140
agaggtttcc atacaaagct gtatcccatg gagagcagct actggcactg aacaatggct19200agagatactc tacataggga aggggctgac aattattcag tttaaatcaa tcacttgtgc19260atatatctcg atagaacact aggctagttc gttgtgtgtg tgtgtgtgcg tgtgtgtgtg19320tgcatgtgtg tgtgtgtgta tgtatgtaat tcactgctta ctctataaca gagagaatat19380caattaaatt gggccatata ggaagatcaa ttaatatatt tgttaattga ggaacttttg19440atggccttgt tgatccccta tggtttgatc tttaaatctg tagtgtttat tagactcact19500acagactctc tgtaaatcgt aagacattta catctataaa tgcattttaa aacatcaaat19560tttaaatttt gcagcactaa aatgtgtcag acaatattct caattaactt gcattaatat19620ttgcttagtg tctgataaaa tgtgtagtgt aggacaaaat gtcctacata atcaacaaaa19680cactcttcca aaattaaaca taatatttgt taagatggtc actgtttttt taaaaaaaga19740gcactactac acagatcaag ccaatgagcc ccagtcagtt gacagaagta catatttggg19800actccttctc taaatttttt ataaaaatac ctgaagaaga tgaatagtca tttgctttct19860tattttaaaa gatctgtccc cccaactaac tttttaatct tctacttgtt accaaatacg19920ataaaaagga gagggggaaa aaagcagaca ccagtttcat tcgtgaatgt aaactttggt19980tttttggttt tcttttcttt ttttttttga gacagggtct cactctgtca cctaagccgg20040agtgcagtgg aacgatctca gctcactcac tgcaacctcc acctcccagc tcaagccatc20100ctcttacctc aacctcccaa gtaattggga ttacaggcgc agccaccacg cctggctttt20160tttagtagag agagggtcca tgttgcccaa gctgacctct aactcctggg ctcaggtgat20220ccacccacct cagcctcccg aagtgctggg attacacatt gcacctggct gaacttctga20280aatgaatgaa gtgctcctaa atgaatgaac atcttgaatg gcaaattaag tttcaagtga20340catataagcc aacaagtatt tctaaatttc taaaataaat ttccaaattc gaagtcattc20400tttcttttct ttcttttttt ttttttgttg ttgttgtttg tttgtttttt tgtgtgtgtg20460
tttttgccgg tctgttttta atcgtggcag cgcctcacac acacattcag ggttcagatc20520ttgttcaaag ctgcgatgtc gacactctgc acatgctcct caaacttggt gatctcctcc20580tccagcaagt ctgtccccac tttgtcgtcc tccaccacac actgaatctg catcttccgg20640ataccatagc ccacggacgc cagcttggag gccccgctca ctagcccatc cagctggata20700gagcgcacac atgcctccag ctgggtcatg tccgtcttat tgtcccaagg cttgatgtcc20760agcaggatgg aggacttggc caccagcgag ggattcttgg ccttcttggc gtacagccgc20820agccgctcct cccgcagccg ccttgcctcc ttgtcttcct ccttattgtc gctgccaaca20880gatcaatgtc atcgtcctcg ttatcctctg cttcttggcc ggggtcgtag taaggggggc20940gaggggaggg gcgctccact tggcgcatgg gagacacgtg ctgtgtctgc gggactgtgg21000accatggcca ggcgagctct tctctcttct ccggcatgtt cagccaggcc tccaggttgg21060agaccgcctg ctgcagctcc tgcaccacgc cgcgcaggct ctggttctcc acttccaggc21120tggcgatctg gaggacgagc tcgctgtggt cttccctggg gccgagctct ggcgggaggc21180gctggccaca ggcccattca tctgcttgta gaatttcctt tctgtatctt catatttgaa21240tttgtcgagc cagatcttct catgtgctag gaattttgta gccatttttc tgacgcctgc21300caagaatgcg gctaccagaa atgaggaatc ggtagacgca ggacgcctaa gggcgaagtt21360gctctttcat aatgtacaaa acccttaagt cttcaacaga aagcaccttt tttatttaaa21420agaaaatcct gcagtttgca aataaaagtt tgtatttcag agagttggtg aggaaataat21480ccattaaaga ctgcctttat aaacataaac tgctgggaat aaagtaagat ttttaaaaga21540caatgaaaac attctgacat ctcaacagga gttagcctga tgaatccatc tcataccaga21600agtctttgtt ttctatttct ggctccttca ggagctcaag gttttacctt ggacaggtca21660tttcatctgt cagagccttg tttctcttac atcaaaggaa gaggcttgtc tgtaaaatct21720ttaaagttct tctttttctc aaatataaaa ttatcattca gatactcttg gtataatatt21780
taaaaattat ttaaatattt aaagaaaaat gttttgaata tttttctata tactgagctg21840ctatgttgag aaatcccaga ggtattattt cagtgtacta ttgctctgat gaccagctac21900cactggagag gggtactatt tcttccttaa aacttgtata ttcccctcaa atactgatgg21960aggaaagagt acatgaatct ttatagtaaa agatagacaa ttagatataa ttgatcttaa22020tagatctgta gataatatgg accattatct acatatcatt tgttaaatta atgccttcta22080gcactcagct aaactaattg tatcgtgtgt gtgtatttct taagcaaagt ttgtttcata22140gatcagtgcc cctgggctag acaggaaaat gtcaaagctc ttaaaccagt ccaccaaagt22200atgtcaacta aaagcctcag aactagtagt atttctcgtt aggttttcag ttgcagggta22260gagaaagaaa gcaaaatcac aaggcaggta tttttctaca gcagtttgat ttagcaaatg22320ttgaacaaat aaaccattaa ctaaataaaa tattgcatat atatatatat atatatatat22380gtatattgtg tttattttca tgttgtctga catcctgaca actaaaggga aaataatata22440gaagtatttc tacattattt tgtgtctctg agtttgtgtc tctgagtttc ctgggcaaac22500tttgtgtctc tgagtttcct gggcctgaaa taattggcag ggtgaatctg aaatgcagac22560acagaaagtc acccttggtt tgatgccctt ttttttttcc ttttcatgtt tatattttgg22620tgcatttccc cccgatatca aatattacct tggtactaaa aaaatcaaga agggaaaatg22680caggcaggag aacgaggaga atcaccttgt tacttctctc ccatatatga ttgggctcat22740gtgattggtg cattagactt tgtagtgtca tttcactcct ttctctgtag acatcaatac22800taacaaatga actgcaaaat cctaaagtgt gaggataaac accaattatt tatgtatgca22860catcatttgt atggatttct aactattgat cttcaggtaa atgtctagac agaagtagat22920ttaaatgtat aggtagttgt gctatatttt tacatttata gtaattaaca tctagaaaag22980caagaaggaa gagacaaaat atcagttatt attttgccta cttgcctctg caaaaaagaa23040gaaataaaag gattgccttc tatctacctg agacagacat ttaaactata gtgaattcag23100
aatctttagg cattctcctc aaagtttcct tcagtgaaaa ttgatttgaa tcaaaaattt23160atgttaaaaa aaatggcagg gccaatgttc ctagcagagt tatctgaatg atttgctagg23220tcaagcaatc ggtcaactat tttcctctag atcataggat tagcatatca ggccagatac23280ttatcctgtg caatgttgag cacagttatt tttggaatct aagagatcat atgatttgac23340actcctaaag gagaccttct aagactttac ttccaaaaaa ctgactggat attatagtaa23400aatataattc ctatactaaa atacagctgt aaaaaccaaa atgcagcttg aatacattta23460gagggagtct tcagtgcttt gtccattaga taaaaagatt gcaaattaaa agtactcaaa23520aattgcagtt gacattcaga aactcattag cttctttctt tcccaaaatc accatagcaa23580ttagtctaca ctttaattgg tcaaaattat tcatcattaa aacactgatt tctaaaagac23640catttttttt cccctctgtc ttggacttaa attttttagg aatttaaatc ttctttctct23700accagtttct gaaatgatta agcacatttg cattttatct gtctagagaa gatattcctt23760cccttgaact ctctcattct ggcctcttct gcttggtcaa ctgtctgtgg aaattctgtg23820ctgatcatct atagattaca tgctaatcta tatttcctaa gaaaaatagg aaaaatatgt23880acacagggtt cagtttacat ttagaaatct caggatcttc tgtcaattct tacccaattt23940tcatgataat ccctacattt ttttcttaat ttaacttatc cagtttaaga tgttgcttcc24000ttattaaaat atttatcacc ttaaaattgt ccactacaat ttaatatata gaagctttta24060tattccttcc ttccttcctt cacatgtcca gtcaattagt catttattca ttcagtatct24120tccagtgcca gcactgtgct agaaacatgg aatgaaaaga ggaaagaggt gtgttctatg24180atctaaaaat gttcctaaag gtcaggtaaa caaataagtg catttaaatg ttaagagaac24240aaagacaaga gaatatgcag gacatgccgg aggcccaatg gaaggtagga attttcccat24300ctgggaggca ggtggtgaac cagaaggttt ataggtgaag acgatgcttg aactgtgttc24360acaggtgctt tttgccagat agtctaacag attaaggtgc tctccctata gagggagaac24420
cagagggctg gaaactgaag gacgaattca gggaaaatga caagtagtgc agtctggcta24480aagcagaaag gcatatcagt ggggcaggga ccagttaatg gataataaca agacagagag24540tttggatttc aaaccacaaa atatggtcaa gggaaaaatc agcagagtta agccagaaca24600ataatatgat atatattttt tcatttagac agaatgcact ggatatttaa agaaatagaa24660ataaaacatt tcagaatcta gcttttgctt ctcattgaca aagtctttac taagatggaa24720taaaaatgga agcatggaac agagagagag aagttgtatt tcttcatggg atgacaagaa24780gggtagatga ggctcgccca agtacagtga tgtttacacc taattgatca caaccagtta24840cagatttctt agttctttct ctactcccat tgcttcactt gactagactt agaaatgaaa24900aaaagaaaag aaaaagggtg gattatagag cttaagatct gtgctttggt ccccatattt24960ccaatccttg tcaccaatgc ttggtaaata tgtgggtata taaaaaatta tatttaatta25020attaattaac tatttttttg agatggaatt tcgctctcat tgcccaggct agagtgcagt25080agtgcgatct cagctcactg caacctccac ctcccgggtt caagtgattc tcctgcctca25140gccttccaag tagctgggat tacaggcatc cgccaccatg cccagctaag tttttgtatt25200tttagtagag acggggcttc accatgttgc ccaggctggt cttgaacttc tgacctcagg25260tgatacaccc gcctcagcct cccaatgtgc tgggattaca ggtgtgagcc acaatgcccg25320gcccttaatt atgttttttt aaagctatat gacagtaacc aaaactatat gattgaggaa25380atatttgtag aaatgatata tatgacaaca gtagcaaaaa ggacaagggt aaataaacag25440aagtcatatt tttcaaaatt cttgcacttt attagaagta ttataaaatt aattgtaagt25500agattgtggt acttaataat gaatgttgta aaccctacag catacactaa aaataatgta25560aaaatgtata tttaaaaagc caatagagga attcaaagga atattttata acaacatcag25620ttaaccttaa agaagacaga aaataaggaa gacaggaaca aaaatacagg tgagacaaac25680agaaaagaca tagcaagtta tagttgggtc ttgattttca aaatctgggc taagaatttc25740
catcttttaa tggggagaag taatctattt ataacaaata taattgtcaa ttaagttggg25800cttaagtcct attaaaatat atagattttt agcctggata aaaatgtatg gccccattat25860atcctgtcca taagagaaaa actttttgtt aagaaaatac agattgattg aagcaaaata25920atggaaaaaa ttataccatg cattcaataa acataggcaa tatggagtgc ctatattaat25980accagaaaaa aatagacttc aatgtaaaga gtattatcag atatgaagaa gaatattaca26040taataataaa ctgctgattc attaaggaaa tataacaatt atatatgtgg gaaggtggag26100caagatggca gaatagaagg ctctaccgat tgtccccact accctgcaag gacaccaaat26160taacacctat ctacacagaa aaaaatatct tcagaagaat caaaaatcag gtgagcaact26220cagtacctgg ttttaacttt attgctgaat gaggcactga agaaatagaa aaaaacagtc26280ctgaatccca atgccttcct ccctacccac agaaactgag tgtggtgtgg aaagcatctc26340tcagtgctga gggaggagaa tacagcaatt atgaggcatt gaactcagta ctgttctttt26400agagcagaaa ggaaaatcac atcaaactta gctgatgtcc acccacaaag ggagcattta26460aaccagcccc agccagaggg gaattgctga tcccaacagc tgaaacttga gttcctgcaa26520acctccacac cgagggatac aatactctat gtctccaagt aaacttgaaa ggcagtctag26580gccataagga ctgcaacttt taggcaagtc ctagtgctgg actaggccta gaatagtgga26640ctgggctggt gcagtacata ctgagacacc agctggggca gggctgcaca gggtagaggt26700aatgctagca ctccctgagc cagacaccac cacctctccc ttaagcctag gctgcacaag26760tctctccaaa agagacccct ttcttccact tgaaggagag gagaggacag aatggggagg26820actttgtctt gcaacttagg tattagctca gccacagcag gatagagcaa tggtcagagt26880caagaagccc ttgttctagg ccctaggtcc cagacatttc tagacatacc ttgggccaga26940agggaaccca ctgccttaaa ggaaaggacc cagtcctggt agcattcatt acttgctaac27000tgaagagtct ttgggccagg aatgaccatt agtgatacac aggtgctatg tcttgggcct27060
tgggtgagtc tctgagactt tctgacttca ggtgaaactc atcatcttac tagcttggat27120ggctatgggt caaaactccc tctgcttgag aaaagcagag ggaaaagtaa agtcttgcac27180cttaggtaca agcactgcca ctggggggta gagcaccaag tggtctcttg gggtccctga27240ttctagcact tgactcttgg atggcatttc tgcacctgcc ctgggccaca gaggtgctca27300ctgccctgaa ggataagtcc caggcaaggc agcattcacc acaagctgac ttagagccct27360tgggttttaa gggaatattg gagatagtct ggcagtactc cttgtggcct ggggtggtgg27420tggcaatggg gtgaagctcc tctacctttg gaaaggggag gaaagtgtgg gaaggactgc27480atcttgtggt ttgagtgcca gctcagccac agtacaatag aacaccagaa gacttctaag27540atttttgact ctagtctctg aactaccaga ctgtagctct ggacccacgt ggggcctggg27600ggaccttgcc accctgaaga aaaggacaca ggcctggttg gctttgccac tggctgattg27660ggtagcccca gggccttgag tgaacatagg cagtagccag ggagtgacta cagcaggcct27720tgggcgaggc ccggtgctgc gctaacttta gatctgaccc agtgcagtca tagtagtggt27780ggacacagag gtgcttgtgt tactccaaat ttaggtgact tggaacagag agactttgtt27840catttggaag aaattaagga aagagaacaa gagtctctgc ctggtaatcc agagaatgct27900cctggatctt atccaagacc atcaaggcag tacttctatg agtctgcaag aaccacagtg27960ttactgggct tgaagtgccc ctaaatcaga cacagcttag atcataacac ctaagccctt28020tgaaatatct ggaaagcctt ctgaagaagg acaggtacaa atatgcccag acagtgaaga28080ctacaataaa tactgagttc ttcaatgccc agacaccaaa gaacatctga cagcatcaac28140actatccagg aaaatatgac ctcaccaaat gaactaaata aagcaccagg gaccaatcct28200ggagaaacag agctatgtga cctttcagaa acagcattca aaatagctgt atagaggaaa28260ttaaaaagaa attcacaata agacagagaa ggaattcaga attctatcag ataaatttaa28320caaagagaat gaaataatta aaaagaatca agcagaaatt ctgaagctga aaaatgcagt28380
tggcatactg aagaatacat cagagtcttt taatagcaga tgtgatcgag cagaagaaag28440aattagtgag cttgaagaca gggtattcaa aaatcaacag tcagaggaga taaaagaaaa28500aaagaataaa aaacaatgaa gcatgcttac aggatttaga aaatagcttc aaaaggataa28560atctaagagt tattggcctt aaagaggagg tagacaaaga gataggggta gaaattttat28620tcaaaggaat aattacagag agttcccaaa cctagaaaaa tatataaata tccaagtaca28680caaaggttat agaacaccaa gcagatttaa tccaaagact acctcaaggc atttaataat28740gaaactctca aaggtcaagg ataaagaaag aaccctaaaa gcagcaagaa aaaaagaaac28800aaataacata tgatggagct ccaataagtc tggcagcaga cttttcagtg gaaattttcc28860aggagagagt ggtgtgccat atttaaagtg ctgaaggaaa aaaaacttgt accctagaat28920actatatctg gcgaaaatgt tcttcaaaca cgaaggagaa ataaatactt tctcagacaa28980acaaaacccg agggacttca tcaataccag acttgtccta caagaagtgc taaaaggagt29040acttcaatca aaagaagaca tcagtgatca ataagtaatc atctgaaggt ataacactca29100ctggtattaa taagtataca gaaaatcaga atattttaac gctgtaactg tggtgtgtaa29160gctactctta tcctaagtaa aaagactcaa tgaagaacca atcaaaaata ataactacgg29220caacttccca agacatagtc agtacaataa tatataaata gaaacaacaa aaagtttaaa29280agcagggtgg gcaatgaagt taaggcatag attttttatt tgttttcttc ttgcttgttt29340ctttgtttat gcaaacagtg gtaaattgtt atcagcttaa aataatgggt tataagatag29400catttgcaag cctcatggtt acctcaagcc aaaaaacata caatggagat gcaaaaaata29460aaaagcaaga aaccaagtca taacaccaaa gaaaatcacc ttcactaaag gaaggtggga29520aggaatgaaa gaaggaagac aagatcacaa aacaaccaga aaacaattaa caaaatggta29580ggagtaggtc cttacttatc agtaataaca ttgaatgtaa atggacttaa tgctccaatc29640aaaagacata gactggctga atggaagaaa caagacccat tggtcttttg cctccaagaa29700
acacacatca cgtataaaaa catagactca aaataaaggg atggaaaaag atattccatg29760ttgatggaag ccataaaaaa gtaggagtca ttatacatat atcagacaaa atagatttca29820agaccaaaac tttgagaaga gacaaagaag atcactatat aatgatgaag gggtcaattc29880agcaagaaaa tataataatt taaaatatat atatgcaacc aacactggag cacccagata29940tataaggtaa atattagagc taaagagaga tatagaaccc atatacaata atagctggag30000acttcaacac cccactttca gcattggact tatcttctag acagaaattc aacaaagaaa30060catcagactt aatctgcact atagactaaa tgtatctagt ggatatttat agaacatgta30120atgcaatggc tgcagaatac acattctttt cctcagcaca tggattattc tcaaggatag30180accatgtgtt acatcacaaa agaagtctta aaatattaaa aaattgaaat aatatcaagc30240atcttctctg accataatgg aacaaaacta gaaattaata aaaagaagaa tttgggaaac30300tatactaata caaggaaatt aagcaatatg ctcctgaatg accagtgggt caataaagaa30360attaagaagg aaatttaaaa atgtcttgaa ataaattata atagaaacac aacataccat30420aacctatgag acacagcaaa agcagtacta agaggcaagt ttattgctat aagtgcctac30480atcaaaaaag aggaaaagct tcaaaaaaca atctaataat gcatcctaaa gaactagaga30540agcaagagca aaccaaaccc aaaattagtg gaaaaagaga aataataaag atcagagcag30600aaataaatga aattgaaatg aaaaaaaaat tcaaaggatc aatgaaacaa gaagttggtt30660ttttaaaaag ttaaacaaaa ttggcaagcc tttagtcaga ctaagaaaaa aaggagagaa30720gatctaaata aataaaatca gaattgaaaa agtagacatt acaactgata ctccagaaat30780tcaaaggatc attagtggct acaatgagca actatatgcc cataaatttg aagatttaga30840agaaatggac aaattcctag acacattcaa cctagcaaga ttgaaccatg aagaaatcca30900aaacctgaac agaccaataa caagtaatga aattaaagct gtaataaaaa ttttcccagt30960aaagagaagc ctcagacctg atggcttcat tactgaattc tatcaaacat ttaaagaact31020
aataccaatt ctactcatac tcttattaat attctgaaaa atataggagg agggaccact31080tccaaattca ttctacaagg tcagtggtta ccctgacacc aaaatcagac aaaagcacat31140taaaaaaaag gaaactacag gtcaatatat ctgatgaata ttgatacaaa aatcctcaac31200aaaatactag caaacagaat tcaacaatac ataagaaaga tcattcatta tgtccaagtg31260agatttatcc ctgagatgca agaatggttc aacatatgca aaccaatcaa tatgatacat31320catatcaaca aatgaaggat aaaaaccata tgatcatttc aattgatgct gaaaaagcat31380ttaataaaat taaacatcac tgcatgataa aaactctaaa aaaaaaaact gggaatggaa31440ggaacatatg tcaacataat aaaagctatg tacatcagac ccacagctag tatcacactg31500aatggggaaa aactgaaaac ctttcttcta agatctggaa catgacaagg atgcccaatg31560tcaccactgt tactcaacat agtattggaa gtcctagcta gagcaatcag acaagagaaa31620gatataaaag gcatccaaat gggaaaggaa gaagtcaaat tattcttgtt tgaaatgata31680tgatcttata tttggaaaaa cctacagact ccacaagaaa actattaaaa ctgataagca31740aattcagtga tattgcagga tacaaaatca acaaacaaaa ataagtagca tttccatata31800taacagtgaa caatgtgaaa aagaaataaa aatgtaaccc catttgcaat agccacacat31860ataattaaat aactaggagt taattgagga agtgaaaggt ctctgaaaac tatgaaatgc31920tgataaaaga aatcgaagag aacacaaaaa atggaaaaat atttcacatt ggtggattag31980aagaattaat attgttaaaa tggccacgct atccaaatca gtctacagat taaatgcaat32040ccctatcaaa atactaatga cattctttac agaaatagaa aaaacaatcc taaaatttat32100atggaaccac agaacatgca gaatagccaa atctatccta agcaaaaaga ataaaactgg32160aggaatcaca ttgcctgact tcaaattatg ctatagagct atagtaatca aaacagcatg32220gtgctggcat aagaacagac acataaacca atggaacagg atagagaacc cagaaacaaa32280tccactcacc tacagtgaac tcatttttga caaaagtgtc aataacttac cctggggaaa32340
ggaccgtgtc ttcaataaat ggtgctggga aagctagatc ttcacaggca gaaaattgaa32400actagacctc tatctctcac catatacaaa aatcaagtca atatggatta aacacttaaa32460tttaagacct caaactctga aagtactaca ggaaaacttt ggggaaaata tccaggacgt32520tggtctgggc aaaaatgtct tgaccaatac cccagaagca taggtaacca aagcaaaacg32580ggacaaatgg aatgacatca agttaaaaaa cttccacaca gctaagcata caatcaagaa32640agtgaagaaa caacccatgg aatgagagaa actatttgca cacttcccat ctgacaaagg32700attaacaacc agaatatata aggagctcaa acaactctac aggaaaaaaa tctaataatt32760caatttaaaa aatggtcaaa agatttgtat agacatttct caaatgaaga cataccaatg32820gcaaacaggc gtataaaaaa tgctcaacat cattgatcat cagagaaatg caaatcaaaa32880ctgcagtgag acatcatctc accccagtta aaatggcttt tatccaaaag acaggcaata32940acgaatgctg acgaggatgt ggagaaaagg gaacccttgt acactgttgg tgggaatgta33000aattaataca accactatag aggtcagttt ggaggttcct caaaaaaaaa aaaaaaaaaa33060atctgagctg ccatatcatc tggtaatccc actgctgagt acatagccaa aagaaaggat33120atcagtatac caaagatatt tacactcctg tgtttattgc agaactgttt acaataagta33180agatttggaa gcaacctaag tgtccaccaa caaatgaatg gataaagaaa atgtggtaca33240tatagacatt agagtattat tcagccataa aaagaatgag attcagtcat ttgtaacaac33300atggatacaa ctggagatca ttatgttaag tgaaatgaac caggcataga aagacaaaca33360tcacgttttc actaatttgt gggatataaa atcaaaacaa ctgaacttat taacatagag33420agtagaagaa tggttaccag aggctgggat gagtggtgca agcctgggaa aggaggtggg33480gatgaataat gggtataaaa attgtagtta gaatgaataa gacctgctat ttgatagcac33540aacagtgtga ctatagtcag tactaactta attgtgcatt ttaaaataaa aacagtgtaa33600ctgcatcatt tgtaactcaa aggataaatg cttcagggaa tggataacct attctccatg33660
atgtgctaat ttcacgtttc atgcctgtat caaaacatct tctgtgctcc ataaatatgt33720acacctacta tgtacccaca acttttttaa aaaattaaaa tatatatgtg tatgtactaa33780taacagagct tcaaattcaa tgaaaaaaaa aacacaaaat ttgacagaac cgaaaaaaga33840aataggcaat tccaataatt atatcacttt tctctcatta atgtagaaca actaggcaaa33900ggaatcagta actgtatgga atatcagaac aaaaatatca gatactttca gttaactaac33960atcaacagaa tacatccaat aactgcagaa tatacattct ttttaagtga acatagaaca34020ttcaccaatg tagctgatgt gctaaacatg tctaaataaa ttttaaaacc ttgcagtatt34080gctgactata atctctaacc acaatggatg taaattagaa aaaaatacga tgtctaggaa34140agtctggaat atttgaaaat taaataacca actctaaata atattaatat atgggccaaa34200ggtgaaatca caagaaatat taaacaacat tttgaagtga atgataatga aagtacaaca34260tataagaatt tgagaaatgg aatggcaaat tcatttgctt tcatgaggtg gtaactaata34320tagaattgcc ccctttctgt aaataattag aaaactggac caaatatgta aaacagttat34380ttttaaagat tggcctatag ataacaaagg actattattt tcttaacaaa tgagttaagc34440cctaccagct agaggaaaaa caggtatgta aggatgatca cagatttctc ttcatagttc34500aacactaact atgtgttgtc tgcatgagac acatttttaa tataatgacc cagaaatact34560taaaaataaa agaatgggaa tatatgtacc atgcatttaa aaactattat gatataccaa34620ggaggctgca gcaccacttc tgtggtattc ctgccaaaag tatgtatctt gaatctaatc34680atggggaaac atcagacaac ccaaggtgag ggaaacccca caaaatgact gacctgtcct34740ctgcaatagt gtcaaggtta taaaagtcaa ggaaaaaccg aagagttgtt ccagatgaag34800aaaactaaag agaccttcaa ggggtgattc tgaactggag cttttaaata taagtcttgt34860tggaacaacg ggtcaaactt gaataggatt caaagaggtg gcctaaagag ttaaaagact34920taagtgatag tattgcatca gtgttaatct tctgattttg atggctgcat ttcattatcg34980
tgaaagaatg ttaaatgtct ttgttcatag gaaatacaca ctaaagtagt cagggtgttg35040aggctttagg ttgataattt attctcagat agttcaggaa aaattctttc tgctgtttgt35100gcaacttttg tgtacgttgg aaaattttta tacaaaaatc aacttcaaaa ttgaccatat35160aaatgaatac cattgaaata tcatttaaat tatcagtagt aacattagat gctagagata35220gtggagtaat gccttcaaaa ttctcggggc aactgctgtt catcactgaa tcatacgcag35280atcacctttc aatcaagtgt gagggtaaaa cagcaacatt ttcagatata tgagaactca35340gagtccccat tccctctatc aaaaactgga gaatcaacct tatgcaaatg aggcaataaa35400aaatgcacac agtggtggag agaaacaata aaatgacagt gttctgttgg cctaagaagt35460taaaaagagg ggccaaaaag tagcagaatg ggagagtgtg cagagatatg tctggaaatt35520actattttcc aatgtagata ttttaaaata ggtgcatgca tttctttact gattatttaa35580aaattatatt taatatgaat ttaaagaagt gagtggggaa atgaagacgg caagtaaagc35640ctaatttttt taacagcaaa taaaggagaa agcagagaag gtagttaaaa aggaatctat35700gtttgagaga ctgtttttcc tgctaaatta agagaaataa gcatggtact gtgatctgaa35760ggaaagccag aaactgggtg accaaataaa atgcactaga aaagagtgct tttttactaa35820ggttggtaga aaggaggtga tgtaccaagt agatagaaat aatttgtagt ctagtgtgct35880gcagagagcc tcacttttct ttatacaaag gcatattcta agaaaaaaaa aatagggcat35940agatggataa agaggattgc aaagctttgc aaaaagttga aataacatcc atgcctcata36000gttgagggag ctaaaagagg aacacacaga agaattgccc agcagcatgg atggtcctgc36060tgaggaggtg aacatgaatt tttaacagca ttagccacac atttgtatag tgctttttaa36120agcttttatt ctaatgtttt tggcagcctg ggtgtagcta ctaaatttag atttgggatt36180tgcccagtct tgcaaacaag taataaccca gggtatggcg taaactaaaa agaaaaagaa36240gagaaactat gcaagtatgt caggcagaat tcaactggag gtcaaaattt gctgaaatag36300
caggtagagt gggattaaag gagcaaaaag aggggattct atgaagttgt ggtccatgaa36360agactgagag gaggagggga agaaattcag aattgaaatt gactactcaa aaggcttgct36420cgtgaaaaaa actgccaata aaaaatcaag catccttgtg tacaaagaag aaaatcaaag36480agagatgcct agggaccttc agttgttttt aggaagttaa gctggcctag agtttcttgc36540tgagtatcct tgcattcgtg gggatgacat ttctgggaca aagcaaactt ccaccacatc36600aaactacctg tggatgataa accaactatg atgaagttgg ccttttccag gtttctacct36660tggcaccaat ttaacacttg catcctttct agcaaggttg ttttttattt atgtttttta36720tttcctctgc atctcagtga tagttgtctt ggcacacagt cccagctgca gacagctttt36780atttttaggt ttccctattc agaaagagta gtccctgttt aggcatttca ctgtcattct36840aagctttcca ctgagctaca accctgcagc tttcttcaaa ttcaagtcac tggggagggc36900ttttgaaatg ctcaaagaac gagacaacat tttgtacaaa ggggaaaaag caaccataaa36960gatattccaa aaccaagtag ataccatgaa aacgaatgga aaagagaaga cagtgacagg37020aaccaaaagg acaaaagaca atatgttgaa tctgtaataa gccagccaga agccccaagg37080acaatggtag gaacctacag atagaggtct gcacataggg aaataaattc ttacttcgtg37140attcccaaaa gcaccaccca agttactaga ggtgacaaaa atacttcctc ttattaaaat37200aaggaagtta ttttgggacc acattattag tgaactggtt agttttagag agctcttcta37260gaaactcatt gaggtataga ttttcaaagt agttaagtac attatttgag taaaataaca37320ttatgttcaa cctaacttac aaaaggaata gtataattaa acagacttgt gcctggaact37380gaaaatatac tcagttaagc attgccatat tttataaagg atgttagaat ccctttaccc37440tgtatttagt aatcctagct gtgatgcaag atagattaat agataagcca caaagtaatt37500gtaatcaaac ataaaggtac aatttaggaa atgggtaatg tacctatagg tgcctaatcc37560aatatatact tcatatgatg cccaaatatg ccgcattttt ggtctgttag aggagcatga37620
aactagtgat ggtcaggaaa tgattcagaa agcaagtcct aaggcagttg caaagctgta37680gaaggaaagt cctggaaagc tttaatgttt tgggcttgca aatgggtctc tttgtcctca37740aatgttttaa gaataatttt tcagtcataa tttgtaaaaa ccaatggcat ttttgttgaa37800aatattttgg cctcttgagg tggacttgca gaaaatactg caacagcact tttgtacccc37860cactaaccat ttcgatgaac tcagctgtat catctcctgc cctcacccac tgtttcactc37920ctggttactg ccctctgttc ttagcatata tgataccctg ccatggctca ttcgttctca37980gcaaggggac aaggaactca agaactggca gcacgagagc aagttgcctc aggccagggg38040tcagacccgg ctataggtct tgccttgtct cctctccact ttctctattt ctttggctct38100cctgacaatt tctcatagct tccctgtttg agcacacatt ttgcttttcc ccttgcattt38160ctattgatca tccagaagct gtttgctggg gcctttgcaa ctcccagctt gcaatattta38220tgtccattct cttgatacct atgtgtatcc atttccctga cattttaaaa tgtgtttctc38280ctcagtttta gctcttctcc tgactactac tttgccctgt ccctagatat cctgccataa38340ttaatgttga atgaaagaat ctaatcaacc aagactggaa attcatacag actttgaaat38400ggggacaaaa tcttacattt gtttctagtg tgtccccata gatttgacta tcacactttg38460gggcatcagt ggcattaagt gacaaattac ttctgggagt tgtaggatga ttctatgtca38520agctctccac tcagatccaa tgagtcacta gttcctactt atgaacaggt attaacttgc38580ttcatttgca aaccccagca agaattttgg tcacaagcca cagttgccat aagaactggc38640tttggaataa gttaggcttt ggttcctatg ccagctctcc catgtcataa ctttgatcag38700gatagcaata ataataatat tttttctccc aagacttacc atagagtttg gtacatagaa38760agtacttaac tactatgatg aggcataaaa atgtttaatt aatcaccgag atttaaactg38820acttttagag gaactttctt agcaggtacc tggttcccca aagtttctca tgcccatgac38880acgcactata accttagcaa aggttatcag gatcttctgt tgactgtgct gttctttctg38940
cacttttggc ttcttggaaa cactgtccct cccaacagtc catgctgaga gtttccaact39000gggtaatcac atctgtctag tcagatgcta actttctgct ccgcagaggt atgtccctca39060aagttcatac ctgaggaatc atttggaaag attccttcct tcaatatctc tggctgagtc39120atgcatacct cctcatcaaa gacaaataga aaacaaggtc aataggaaag cggtgctcac39180ctatcttact gtctgtacct tttcctatta tgactagcct cataatcttt aggttagaat39240gacttgcact aacctgttcc tagagtccct tccttgtccc ttgtggcact tgccagttgt39300gattgcaact ggtggtttta agcatgttac cacttcaaaa ctccaagctt tatgaaaacc39360aagaagatgt atgtaccatt tgactatttt tatatctccc atttctagcc caggggttgg39420cattatcaca tagcagttaa gagcttgtga tctggagcca gcctgcgtgg ttcagcttaa39480aactcaactc catattattt atgtgaattt aggcaagtca ctgaaattac tcctacttca39540gtttactttc ctaaaaacag gtattttcat aatagtgttt acctcttagg agagattaaa39600taagtcaata tgcataagca cttaggacaa tgcttggcac agagcaagta actattaaaa39660taggtactta gtaaatattt gctggattag caaatgccac aataggtcca gtcatcagca39720ttttgcagac atcatttaat caacccgaat agtccagtgg ctctagagtc tcttaatttc39780ttttttcatg attttttttc atttactgcc tctcaggctt tattgcattt gtgtcaaatc39840cacttgtcta aacatttaaa aaagcaaaac agtgttacat agttttaaaa accattataa39900tttgactcta tgagtttcaa aaacttcata tacaagtgct taattgtctc attcgaggtt39960ttacattgct gatgaaatcc actcatttaa gaggtaggta gtaatgcagt gtgtggggtg40020taaagtaaaa tgctaggggt gtgtgtgtgt aggtatgttt gtttatatgt gtgcttgtgt40080atatttttat gtgtgtatgt taggggtagc tggctgtgcc aaaggtgaat aagatgaagt40140tcctgctcta tagaatcttg aaatttaata aaagagataa ccatgcaaac aactaactaa40200atcacaaggc acaatcctct gtgagcctgt gagtatctgc atcctgctct gggaaagtgt40260
aataatctct ttttgtgtct acgattgtac ccgggctggc atctgagtta gatcataggc40320tcctaacatt tcactttatc agttcgtaca atgccccaca tctctgtgag ctaaaaaaac40380atgttgctat cagcacaatg tgagaagaat ggtttttttt ccccgaaggg acaaaagtag40440tgccataaag ctatagaata ggcaagtctc tcagtaaaat gagtttccct aaaaggattt40500cctaaggaac atcttaaggt atttaaataa acaaacaaat aagacaactg agtagagttt40560aagtctgtgc cttttcctta ttctctagtc ctggttcttt tgacgtaaag tgaaacattt40620ttggggttat ttatttccac ccccactctg tcataatata aagagaattc tcagagggga40680gactatagaa gtctgtcagc agctgactct tttctggcag gaagactatt ttataaaaaa40740aagaagaaat ggatttcctc tccttgtagt tcaatatttt cttcctctac acattggtta40800aattcctcca tcctatttcc ttgaaaatgt cagggttggg ttgccccaat ctcagacagc40860tctcttcatt atgattatca gtgttaatgc catgtcatta atcctcacga gtatatggag40920gcctcacact gaatgaatgg ggaaggtcac catggaaaca tctgtctcca tagatgactc40980acggcaaccc ccataactgc tgaaccacat cctgtctccc aaatgcactg gatgaagcca41040caaatttggc atttcctaca ggaccatatt ctttttaaaa gctattaaaa atctatgcca41100gggaagcatt tttcagactc atggcaataa tactctttgc aatgtgttta agtgggtgat41160gctatgcaat tagttgttaa caccttttaa taaatgcaca cagtaaacat tacctgtggt41220ttttcagctc ccggtttctt tgcagtgctg tcatctctgg agacaggcgc tggcagagag41280aaaagtgccc atgtagaaaa taagcaaaac acctgcattc tcacatttca gaaatgatcc41340tccttagggg ttagtgtggt ctatcaactt gcatcacagt gaagtggagg ggaataaaat41400ggtctttgct ggatttattt ttttggctgc ctcaatgaaa aaagcaagca agataactca41460tgtagaaaaa ttacatttga ggactgcaga cttctcactt agccttatca tggaacggca41520ggatatcaac atttcctaga tggaaaatta ggtctatgtt gggagatatc aggcttaagt41580
aaaatcacat gacaactact gtgtatatcc cagtcacctc ggcacagcta cgctgagcag41640tctttctagg gttgctatgt tcagagttgg ctgtaactat acacaccgta agcccagttg41700gaaaagcaaa caagggagtg aaaaagggaa cagactattt cccaggctgt acacatttgc41760tgaatcttca caaaggcagg ttgtcatttc ttgtttattt cttgaatcct agatggaaac41820ctggaacttg agtgataata atagtagacc tttgctaact gtacatatat tagctcattt41880gtttctgtaa atgatcatat aatgtgggta gtattcttta cttcatttga cagattaaga41940gactgaggca tggaaaaatt aagtgatgtt accatggtca ccaagctctt aagtagctga42000ggcgggacat gaacccaggc atctggcatc cagtttattt cctttaactt taagccacat42060atttacctct tgtagagtca tatttattcg ttttctctcc tcttgtttcc tctcctcttt42120ctctccctct ctctttctta ccatttttct actactcttt cacacctgcc cccaatcttt42180cccctcaagc ccacacccac ttcctacttc tctcctctct cctctctctc tccctctcta42240ttgctggaag tgatgagccc catctgggtc caccagctgg ccccagacag gggattttgg42300cctctcccaa attaaatcat acttgtaaag caggaaaagc tactccctgc ttccagatct42360ccccttccca ctgaccctcc cttgtccctc tgtcgccttc cttcttttgc ataggcttcc42420agttctcttg tactcttctc ccacagtttt ctcaggaaag aatgggttgt cttaaagtca42480tctgatatgg tttggctctg tgtccccacc cagatctcaa cttcaattgt aatctccagg42540tgttgaggga gagggttgat tggatcatgg gagtggtttc ccccatgctg ttcttgtgat42600agtaagtgag ttctcacgag atctggtggt tttataagac agtttcccta cccttgcttg42660cttctctctc ctgccatgtg aagaaggttc ttgcttcccc ttgtcttctg ccatgattgt42720aagtttcctg aggcctcccg agccatgtgg aactgtgagt caattaaacc tcttttgttt42780ataaattatc agtcttaggt agtagcttta tagtagtgtg agaatggact aatgcattat42840catatagtaa attcagtctc ttcatttaca ttaaagttcc cactttatga acatttgctt42900
tttaaaaaaa actttgttat tgaagtacag tttaccatat aaatggtgtc gtggactgaa42960ctctgtccca aaattcatat gttgatgcct taactcacta tgtgactata tttggagata43020gggcctttaa aaaggtaatt aaagttaatt aaggcctata gggtgggacc ttaatcgaag43080atgactggta cccttataag aaaaggaagt gacacaggga catgtataaa taaagaaaag43140gccatgtgag gacacagtga gaattgttga catgttgatc ttggaattcc agcttccaga43200attgtaagaa aattaatttg ttgttgaagc cacctagtct atgacatttt gttattccaa43260cgctagcagg ttaatacata tggggaaata cacaaaaata ctcaaatctt aagtattcag43320cttgatggat ttctatatat tcataaaccc atgaaatcac tgcagatcaa gaaacagaac43380atttccagta ccccagaaac ctccctcctg ccccttccca ctcacgttag cagtctgtgc43440ccgattttca gatctgcttc cctgcagaga gggttcactt aggcccttct ctctcatgtg43500gaagagcttt acttctgcaa gtgcccctgt gcctgggtct ggatatgaga gtcaattttg43560ggagtcaggg ttggcggggc cacttggcca aagagctaag gcaacatttt ccaagctgtt43620ttcacaagtg ataaagatga cacaataatc ttcatctgat ttctgcatct atttctcaat43680tgtttctgaa ctagggaggg gaaaagggta tcattatctc cttgatacct aacattttgg43740tggttggctg tgtttaagtt tggaattttt aaaaataacc tatttttatt ataaaacatt43800tcaaacattc aaaacatttc acacattcaa aaatgtatat actaatataa tgaactacca43860cctgatttca ataaataaag acgatttact atatttgcct ttgaaaaaca ttttaaacta43920ctttagtaaa taagagtttc ttctattatt cttgaaacct aaaggctctg ggtcttttga43980acaaataatg actctaataa tcaaataaaa atcacaacat gacacaaagc tctcacaatt44040aattctactt tttatctaat gcactttcca tcatgttgca taccatctgt taactaatga44100aatgccctaa ggctcaaatt gataaataca aaaatctccc tttctttgat atgtgattga44160ggattccacg ctgatttgga ttagatcttt gatgaagtag tagaggcaac tgaaagttta44220
agcaaatttg gggttgtcct acatcactaa catcatcctc tgggcaggaa tgggtcttgg44280gatccattta ctttcccttc tctccaacca catatatagg aagagcacct ggtggatcac44340accttgatga tcaggcagct acaccaaatg gttacagaaa atatgaatag gtttgagagg44400ggaagagcgt cataaattct tcaaagaatt gctatatggg tttagaggtg acaaagctat44460tactggtgaa gagtcatcac ggaaagtcct gagttctgaa tgaaaatgct caaaaaatga44520gaaaactggg acttcaaaga taggcataaa caaatggaag catattacaa gtgaaccagg44580cagaacatca aattcaggcc agggttagtt attgttttgg aggaattatc tagggcagtg44640aatgtgaaca gctatgaatg attttgaaca taaagaactc attgacttca tgtgctcact44700ccagagatct aaatagcatg tttgaaaaac aaatggccaa gtcgggagag cgggagagcg44760ggagagcggg agagcgggag agcgggagag cgggagagcg ggagagcggg agagcgggag44820agcgggagag cgggagagcg ggagagcggg agagcgggag agcgggagag cgggagagcg44880ggagagcggg aactgaaagt ggtgagaacc ctacattagg ttgagaagaa acaagacata44940ttaagaaaca agttaaactg ttaatgggaa catgtcttga ttttcttgtg tgattccttc45000aattctttag aattatcaat atgaatgata aaccacatgc atccagtaat aaaaaatccc45060agtctacagc tgctgaggaa attcaaaacc catttgggtg tttgagtgag atacttctgc45120cagcattcag cagtagcttt gcaaggactt acattagggt cacatcctta gtctcaatcc45180agccctcata tccacctact cttaggagaa ggaggaactt acctgattgg tgggtttagg45240attagttaga tataatcaat gcagcccatt cctctctctt cttcttgagt ctgtgtgctg45300ggagaaggga tgtattgtgt gctctttacc acttgatacg accctgctac agtgtggtag45360gtctgccact ttctggctgt acttatggac agaagggaag gggtaaattt gttcatttca45420gaggtgaagt cttagcaagt tcgcactgcc agtgtctaag ccatagtctc caatcacttt45480tgttagtaat aaaagtgtat tttgttagta atataccttt tgtcactttt gttagtaata45540
aaggtatatt ttgatgttat cccaaagttg aacatggagg aaagatatgt ttttcaacaa45600tactttcagc agtattctgc tctatttcct aaatgacagg atagaattaa aataaatttg45660caatgatgta ctaatataaa taaatgaagt atcagtaatg aatgtacgaa ttaagtcaga45720gcatgtagcc ttgaacaagc tggggaacag aatataaggt cttacataat catactaatg45780gctaatattt accaagtgtt tattctgtcc aattaatttt ggtaatattg tgagccccat45840tttttgtgag tcccaatatt gtgagatgac agccaaaaag acgtggagac tggattcata45900atcaagggct tgatctcaga gtgggttctt ttagaatata ctggaaattt attaagacaa45960atttgtctct gaacttcctt gaaaatagaa cttttgttat cagtgctaat agttctttcc46020tttttccttt ttatattgag atatattacc aggagaaaaa taaattatct gttaagacat46080cctgcaaaag tatactccaa aaagtttccc ccaatttatc ctgccagtaa ggggacataa46140gtgtgcacat tttaatccac cttggattaa gatttattta aattaaaatg tattttaaaa46200taggctattg tcacttttta tgtttaattt cagtcaggag agtctgtgga catccacagt46260atcaagcagc ctcagaactt tattgactta aaacaactta gatgtatatt ttgctcaaac46320tacataattt tttacaggct aggtgggtgc tctgtcctct atcctttctc tagaatccca46380cgcagaagag ctgtataggg ttttgcatgt gctattcaat gttcttttcc agaagtaaaa46440aatatcactt agttcacaat ccattagtca taacaagtca tctggcttca cccacttaca46500agttgcctag aagtgcaaat ctaccatgta ccaaaaagga agaaagctag acaacacttt46560gtgatcagca ctaggattgc tacatgtttt tacaagtttt atagctgaaa aatggcaact46620agccttcttt ggcatttaca ttacaagaga ggttatgcaa ttattttctc ttttgtgaat46680tgtttgtgca tgcccttttt ttgtctgaca tattaaaatg ggtatgttgg cagagtcccg46740tagaaaagtt ggtggaggaa tttaagttgt tctcaagtaa tcaacaaaga ttatccattt46800ctactccctg ccccttaccc gctgctgtct cccttatccc ttggaactaa gaagttgtat46860
ataggaaaat attctggagg gtggtggtta cctcatcgta acacactata agcaacatgt46920cttagaatgg tttccatggg ggcattgatc atttagtgtt tcctaacctg tgattgattc46980ataagtacat caatatcaca tgtcaggcta cttcaggtac tctgtaaaag atacctattt47040ttccaaggtg tatttcttag gcctctctca atttgaagtg aaataattcc aatctgaacc47100agttaaaaaa aacaaaacag tgtgtcctca agtaaaagtt ataggggttt cctaggttta47160ggcatggctg gatatgtgaa gtcaaataat aacatcagaa cttactcatt taccactaag47220accaaactgg gaagttaaat ttgagtcttc acttcctcat ctatgtatcg gggataatta47280ttatttttct cctgtgcttg ttgtgaggat tctttcatta attcatgcaa aactttattt47340ttgaggcgga gtttcactct tgttgcccag gctggagtgc aatggtgcaa tctcggctca47400ctgcaacctc tgcctcccgg gttcaagtga ttctcctgct tcatgctccc aagtagctgg47460gattgcaggc gtatgccacc atgcccggct aatgttttgt atttagtaga gatggggttt47520caccatgttg gttaggatag tcggaactcc tgacctcagg tgatccacct gcctcagcct47580cccaaaatgc aggattacag gtgtgagcta ctgcacccag cacatgcaaa acttttaata47640caatgcctta catagtaata gaaatagaag ataactgcct actattgttc ttactacatc47700tactattact gtttattctt atgtatagat tgttcaatac actgaaatga cctaattgca47760tctgtcattc tgagatttga atttagctta actattatct ttagacttta ttattgacaa47820aaagatgaag gtgacaggta tgaaagattt gaaatatgtt tttcaaatat atcctaaacc47880agatttcagg aagagactag aaactggact tgccagattc cacatatctc aatgctgtgt47940ggaatttttt ttaaattttt ttttacaatt tgagatggag tctagctctg tcatcaggct48000ggagtgcaat ggtgtgatct tggctcactg caacctccgc ctccccggtt caagcaattc48060tcctgcctca gcctcctgag tagctgggac tacaggtgca tgccaccaca cctggctaat48120ttttgtattt ttagtagaga tgggtttcac catgttggcc aggatagtct aaatctcctg48180
acttcgtgat ccgcgtgcct ctgcctccca aagtgctggg attacaggcg tgagccaccg48240ctcctggtct gagtgtgtgg aatttgacgc acctatgtgg taacaaaatg gatatatcca48300gtttatagct ggaactctga ttctgtacag aggtcaggat aataaacaaa agaagagtca48360tttgtttatg tcagagattt gttatgtggt attaaatata tccataatgt taggcaaaaa48420tggattgtgt atttttttcc tcctaaatag atcttaataa atgggctact ttaaatatta48480catacaaaga aatttagttt taaagaataa atttgcttga catgacaaat atcaaaggga48540actgaggagc agctacttct ttggccatga ttccaattct tcattcagta tgtatgcaca48600cctattcctc atttgtttgg gtcacttgct tcccctctgg aggaatttga gcactgagtc48660tgatcaaggg taatagagtc cttgacaaag ttcatggcta aggccagaga cctaagtgag48720gttgccattt ggaaacagaa gaaaaggggg ccaattatgg aagtggggag aatagccatc48780caaagaaact gagaagaatc agtaagaaca gcaggagaga gcagtttcac ccaagtcaaa48840gtaggagata gtgctatctt tttatttaca ttattattat tttttaattt tagagatgaa48900attttgtcct gttgaccagc tggagtgcag tggtgggatc atagctcact gcagctgcaa48960tctcctgggc tcaagcaata ctcctgctcc agtcttgcta gcagctggga atataggccc49020tcaccacggt gcctggttag ttttttaagt ctctttatag agaagaatga tcagcgccat49080gttcccagat aaatctaata gacttagtga aaataatcta tgaatttcat caattagaag49140ataatgacat acaatgaaag cagtttcact cttgtgatag ggcagaaatg tacaatactt49200tctgtctcta tgattttgcc tattctaagt agctcatgta agtggaatca tatggtatat49260gtattattgt gactggttta cttcatttag cataacacct tcaaggttca tccatgttgt49320agcatatatc aatatttctt ttttaatttt tttaaatgtt tttagagatg aggtctcact49380atgttgccta gggtgacctt gaatttctgg gctcaagcag tcttcccacc tcagcctccc49440taggagttgg gactacaggc atgtaccaca ttttgctttt ccattcatcc cactggtgaa49500
cacttgagtt acttctatgt tttagctatt gtgaataatg ctgttgtaac atgggtatat49560aaatatctct tcaagattct gttttcaatt ctttggggtg tataccaaga attggaactt49620ctggatcata tgataattgt atttttaatt tttgaggact tgccatactg ttttccacag49680tggctataac attttgcatt ccagcaacag tgcagaagag tttctatgtc tccacattct49740tgtcaacata ttattttcta tgtttttaaa aaagttttcc tgtaatccca gcactttgag49800aggccgagat gggtggatca cgaggtcagg cattcaagac cagcctggcc aacatagtga49860aaccccgtct ctactaaaaa taaaataaaa aaaaaagctg ggcatggtgg tggggcctgt49920aatcctagct acttgggagt cttgggcagg agaatcactt gaacctggga ggcggaagtt49980gcagtgagcc cagatcatgc cactgcactg cagcccaggt aacagtgcga gactccgtct50040caaaaaaaaa aaaaaaaaaa aatttatagt atccttaaca ggtgtggggt gttatctcat50100tgtaagtttt ggcttgcatt tccctaatga ttagtgatgc tgagcacctt tcatgtgctt50160attggccatt tatatatctt ctttagagaa gtgtctactc atgtcttttg cccactttta50220aatcaaattg ttcctttttc attgttgagt tttaggagct ctctttatat tagtatctta50280tcagatatgt gatttgcaaa tattttattc tgtaggttgc ctttttactc tgttgatatt50340gtctttaaaa atgtatatta aaaattctaa ccagcttaat atattattga caaataaaag50400ttatatatat ttgtggtatg caacatgata ttttgatgta tgcatacagt atgaaatgat50460taaatcatgt taattgacat atccattgcc tcacataatt attcacaaat ttttttcctt50520tccataaagt ttaatttgtc tgtttttttt cttttgtagc ctgtgccctt agaatcatat50580ccaagaaata attgccaaat ccaatgtcat aaagcttttg ctgtatgttt tttcttaaga50640gttttatagc ttcttaaggt tttaaatgta gttctttgat ccatttaaat aaatttttgt50700atatggtgtt aggcaagggt ccaacttcat tattttgcat gtggatatcc agttttccca50760gcacctgttg ttgcaaagac tcttttccat attgaatggt cttagctctc ttgtgaaaat50820
catttaccgt atatatgagg gtttatttct gaattatcta ttctattcca ttggtctatg50880tcttccattg gtctatatct atgtttgtga ctgtactaca ctgttttgat tactgtagct50940ttgtggtaag ttttaaactc aggaactgtg actcttccag atttgttcct ttttcaagat51000tgttctggct attcagggaa ctttgatatt ccatatgaat tttaggatga atttttctat51060aaagagtatc attaggattt tgataggatt gtattgaatc tgtagatcac tttgggtagt51120attgctatcc taaaaatgtt gtcttctact ccataaacat aggatgagtt tctatttttt51180tatgccttta atttcttcca gcaatatttt gtagtttttc ttgtacatgt ctttcatctc51240cttggttaat tcctatgtat tttattttta tttggaaata tttattaggt gcccactttg51300ttccccatat tatcccaggg agttattaca aaatgatgag caagacagac atgggctcat51360ggggcttcct catgcatgtc ttttggtatc accaatttat ctcctgtggc ctgtggcaaa51420tgtatggtgt aattctagtc catgagctta gtatacttat tttcaggtac tcactcagct51480gtacttgttt aaaaaaatgc ctgaaacttg atttgcttgt gtggatatta agagtaaatc51540aactattcca tacatgtaaa gtacgtttta ttctccctgt aaaactctca atgtttttct51600tcaaaatata ctttatgata tatatattaa ctattatttt aagatagttg ggaaaatgaa51660gggaccataa tttaaaagaa atggaatatt tgatacatga tgtggctgcc tgtttttatt51720cttgtcacct agtctcagtt tttcaggttt ttaaaaatat tataaatgca cacatgtaca51780cacacttaat ttcttcttaa tctgtgatct ttcaggtttc tattacatag attaattcat51840gtaaattttc ctagtctttt gaaattaaag aaagtcaatg acaaaaggac catcacgtgg51900acaaccagtg ggaatgtttc attcactctt gtaagttact tgttcccagt gcaaaagttt51960aaaagaaagt ctttttattt attcaaaagt tgaaggtttt tttttttttt ctcttcagca52020ccggaaactg tcaggaaaag cagtatatac ccctaatgac tagttcagaa ataaatgtat52080cattgttttt aataatttga tacagtatat aaatgttgtt ttgtaaagtt taaattctac52140
tattaactga acaaaatata aaccaggaaa ttaacatcaa agaaataacc acattcacct52200gttcctctcg tctctaacat tctgcttttc ctttgctccg cagggtaacc atggtgagaa52260agatgttgat ggcttggatg gagaacaggt actaaaattt ctcattctat gttccgcctc52320tactagtttg gcatttacac atgtcatgat taatctagaa atgtaaacat gcatatttaa52380tgtttaaagt ttatctatgt ttgttcttat cccaaatata caagaaccct agaagtctaa52440ctcgaatcaa cctctcccat attacatttc tttccatctt atttttgtta aatctatcac52500ttagacattg ttattgtttt atatagtcaa tgcttattta gccctaccat catatgtctc52560caattttctg gaagagttag agaaggatta gtattcattc tttaaatgtt tggtagaatt52620cactgaggaa gccatcaggt ccatggtttt cttcaagaga ttttttgatt attgattcaa52680tcttcttacc attgattcaa tcttcttacc agttgtaagt ctattcatat tttctatttc52740ttcaggattt agttttgcag gttttgtgtt tctggaaatt tttccatttt ataaagacta52800cctagttgtt ggcatacact tgttcttagt actatcttag aatgtttttt tatttttttg52860agacggagtc ttgctctgtt gcccaggctg gagtgcagtg gtgtgatctt ggctcactgc52920aatttctgcc tcctgggttc aagcgattat tctgtctcag cctcctgaat agctgggatt52980gcaggcgtag gctaccatgc ccacccaatt tttgtatttt tagtagagac atggttttac53040catttttgcc aggttggtct caaactcttg acctcaagtg acctgcctgc cttggcctcc53100caaagtgcta gaattacagg catgagccac ctcacccagc ctattataat tctttttatt53160tatgtggact cattatttcc actttcattt ttgattttat taatttaaat ttttctcttt53220tttttttagt tcatctggct aaaatttcat cacttttgct aatcttgagg aatcaatttt53280tggttttatt gattttctct attatttctc tgttctctat tttatctttg ctctaatctt53340tatttccttc tttctccaag ttttgagttt agttcttctt tttctagttt cttaaggtat53400aaagcgaagt tgttgatttg agaccttttt tgttttttaa cgataagtgt ttacagctat53460
agttttttcc tttagcacca cttttgctgt gtaccataag ttttcgtgtg atgtagtttc53520atttttcatt tgtctctaat tatattctaa tttcttttgt gatttctttg atccattggt53580tgttgaagac tgtgctgtat gatccttttg tagttcacaa gcctgatgat tgggttttca53640ttcacgtgga tgagatgcac ctccctcaaa cctggttgtt acagcatagg cacattactt53700gtctaacacg aaaaaaagga aaaaggagtg tgctgtgcaa tttccacaaa tttgtgaagt53760ttctaatttt acttgtgtta ctgagttcta atttcatcct gttgtgatca gagaagacaa53820tttgcataat atttatcttt tataatccat cgagaattgg tgacttaata tattgtgtct53880ggagttggtt cctcctggtg ggtttgtggt ctccctgact tcaagaatgg agctgcggac53940cttagcagtg agtgatacag ctcttaaaga tggcacggac ccaaagagtg agcagcagta54000atatttattg tgaagagcaa aataacaaac attccccagc acggaagggg acctgagcgg54060gttgccgctg ctggctgggg tgcccagctt ttattccctt atttgtcccc acccatatcc54120tgctgattgg tccattttac agagtgctga ttggttcact ttacagagca ctgattggtc54180cattttacag tgtgctgatt ggttttacaa aactctagct acagagcgct gattggtgtg54240tttttacaga gcattgatag gtgcatttta caaacctcta gctagctaca gagtgctgat54300tggtacattt ttacagagca ctgattggtg cattttacaa accccttgta agacagaaaa54360gtcctccaag tccccattcg acccaggaag tccagctggc ttcacctctc aatatgatat54420atcttgataa atattccatg tgtacttgag aagaatgtgt atgctgttga tgttgagtaa54480tgctctgtat gtgtctgcta gatctagttg gtttgtgttg tgttctattt cctttcttat54540catctgtctg attggtgtct tcattattga gaggggagta ctgaaatctt taactattat54600tgtagaacta tatttctccc ttcatttctg tcagcttttg cctcatatat tttgatggtc54660agttattaga tgcatgaatg tttatagttt ttatatcttc tttctgtatt gaacatttta54720atttataatg tccttcttta tgtctttttc actttttgga tttaaagtgt attttccctg54780
atattggtat agccactgct gctctctttt ggttactatt tgcatggaat agcttatttc54840tttttttctt tctttttttt tttttaaata aacacatttt tttttttttt ttttgagaga54900cagtctccct cttgtccagt ctggaatgct gtggtgcaat ctcagctcac cgcaacctct54960gcctcctggg ttcaagcaat tcttatgcct cagtctccag agaagctggg actacaagtg55020cacaccacca cccccggcta atgttttgta ttttagtaga gacagggttt tatcatgttg55080cccaggctga tcttgaactc ctgacctcag gcaatctgcc caccttggcc tcccaaagtg55140ctgggattat aggtgtgagc cactgcaccc agccagaata gctttttcta tcattccatc55200tttttttttt ttttttgaga tggagttttg ctcttgttgc ccaggctgca gtgcaatggc55260acaatcttgg ctcactccaa cctccgcctc ccaggttcaa gtgattctcc cacctcagcc55320tcccgagtag ctgggattac aggcgtgcgc caccacctca gataattttt tgtattttta55380gtagagacag ggtttcacca tattggccag gctggtctca aactcctgaa ctcaggtgat55440ccacctgcct cagcctccca aagtgctggg attacaagca taagccacca tgcctggcct55500atcattccat cttttcactt tctatctgtt tgtatttcta aatctaaaat gagtctcttg55560tagacagcat ttagttggat catgtatttt taaatctatt ctgccagtat gtatctttca55620attggagagt ttactccaca tttatttaaa gtaattactg ataaggagga cttacttctg55680ccagtttgct atttgttttc tatatgcctt atactttatt atccctcagt tcctgcatta55740ctgtcatctt ttgtgtttag ttgatttttt gtagggaagt gtttaaattt atttctcatt55800tccttgtata tagtctgtag ttattttctt tatggttgtc atgaggatta catttaacat55860cttaaagtaa taacactgta atttaaattt aaaccagctt aactttaata ctatacaaaa55920agtttactct gttatagctt catccccact tatttcagtg gctgatgtca taaaattaca55980gctttatata ttatgcaccc caaaacataa actaataatt cttttaaata cattagcctt56040ttaaattata tagaaaatga aatgtgaagt taccaaccaa agttacaata ttaggttttt56100
gagtaataat tctttaaatg tatttttctc ttaaatcatg tagaaaataa aaagtggagt56160tataaaccat tattacaata atacttgatt ttatgattgc acatgtattt acctttgctg56220agatagttat tttttcatat gtctttgaat tactgtccag tgtcttttca tttcatgcta56280caggcttccc ttgagcattt ctttcagggc agctctagtg gtaatgaact ccctcagttt56340ttttatttgg gaatatctct tttttttttt gacaagatct tggtctgtca ctcaggctgg56400agtgcagtgg cacaactgta acttactgca gcctcaaact cctgggctca agtgatcctc56460ccacttcagc ctcccaagta gccaggacta caggcatgca ccaccatgcc cagctaatct56520tttttaatta ttattttttg taaggatgag gtctcactgt gattcccatg ttggttttga56580atgcttggcc taagcaatcc tcctgcttca ggctcccaaa gtgccaggat tacaggtgtg56640aatcactatg cccagccatc tgggaatacg tcttaatttc ttattttaga aggacagttt56700ggccagagat agaatttttg gttaatagat tttttctttt tttttttttt ttgcacttgg56760aatatattga cccaatgcct tttggcctcc aaagtttcaa atgagaaatc tgcttatgat56820cttattgaaa atctcttgta tgtagtaagt ctgtctttgt tcaatcaaag gtttgattat56880aatgtatctc agtgtgggtc tccttgagtt catcatattt ggattttctt gaatttcttg56940gatgtttata ttcatgtctg tcatccagtg tcagaagttt ttcagtcatt atttctccaa57000atattcactc tacccctttc tctcttctcc ttctaaaact tctgcaatgt gtatgttggt57060ctgcttgatg atgtgctaca ggtcccttag gctctgttca cttttcttca acattttttt57120ctttctgttc cttagactca ataatttcca ttgtcttatc ttcaagtgtc actgattctt57180ttgcctctta aaacctgcct ttgaatctct ctagggaatt ttttgtttca gttatcatac57240ttatcatttc cagaatttat ttttggtttc tttttaggtt ttggtatctt tatatttcta57300ttttgttcat ttatcatttt cttgattttt ttaacatctt cctttagttt tgaaaatata57360tttaaggcag ttgtttcaaa gactttgtct agtggatctt ccatctgtgt tactcaggga57420
cagttttggt tgatttattt ttgtttcctt tgagtgagcc atagtttcca tttctctgaa57480tgccctgtga tttttttttt tgaaaactgc atatttgaac ctaataaagt ggtaactcta57540gaagccagat tctcctccct ttccctgtgt ttgctgtttt ttggttacaa tttattgttt57600attgattttt tttttaattt gagtgtttta agctatctct gtgtcaagga tcagaatgag57660gtatatactt aaggtcttct caggtatttt ctgagtcagt gctttcccat gggcttgtgt57720ggtgataaaa gaaaaacttc agctgaatta aatttgaagg agtttaattg agcaatgagt57780attttgtaag ttgggcagcc cccagaagca cagctgattc acagagactc cagcacagct57840atgtagtgga agaagattta tagacaaaaa aggggaaatg acctacagaa attggtggtg57900aggtacagaa acagctggat tggttacagg ttggtgtttg ccttattgga acacagtttg57960aacacttagc agtctatgag tgcttggagt atggccgctg ggattgccca agacagttat58020tgttacaggt gcatactgtt aaattaggtt tttaatcttg tgtgactatt aagctaggtt58080acagttcatc cacaaggact caaatataga agtatggagt ccttctcacg ccatatttag58140ttttctttaa gtggtcactt tctaattttc ctcacatata ctgctgcttt tgaatgtccc58200agcctttaat gtctggctcc caaaaaggca aaaagaaaaa aataaagggg agagggagga58260ggcagtggcc cttaaaatcc cctggaagtc aattcatttg ggggtaggag ggagtagcag58320caatttgaga agatacaaaa caatagctgc ctgcttcttt gcacctccga gatcaaaaac58380aacaatcagt aatcaaagct cagatcttga tttgcaggac agagttcttt ttgtcacact58440gatttccaca agctgcattc aagctgctcc aggaacatgt gcattgctac ctgacaagga58500actgtgtgta gggtatgtgt agctcctcct gtgcaaacta aagttggcaa aagtaatagc58560aatacactaa acaagccttc ctttggaagg tgcaagcctt caataggatc cacagttcca58620aaatagttac atcagataaa ttctgtcagt acaattgtag tagggagata gattttatgt58680aggcagatag attttaggta gggagataga tttctggttc ttcctattct gccatcccat58740
cttctaaaac tacacctcat gttattatca ttattactat tattattatt tatttttgag58800acaaagtctc gctctattgc ccaggctgga gtgcagtgat gcaatcttgg atcattacag58860ccttgacctc cacccacctc agcctcccaa gtagcaggga ccacaggcat gcaccactat58920gcctggctaa tttttatgtt tttgtagaga cagggtttca ccatgttgcc caggctggtc58980tcaaactcct gggctcaaca tatctgcctg acttggcctc ccaaattgct gggattacag59040acatgagcca ctgtggccag ccctgaattt attttttaaa tagaagattc ataaaaaaaa59100ttgacctcac gattataggt aactagattt tttgcaaatg aaattatctt attagaaagt59160atattagata taagcagtta tatttttacc cagaaccaca ggcagttctt tctattcaga59220gtaaagagcg atattgggta tatttccaaa ttcaaatgtc attctaaaat atatttgtat59280ttttatcagt gccaagtgca atggtagttt gtgcaaatta gtgctcgtag taggagtgtt59340ttagtactat tgaataataa cagtgtaatt tgaaaggtaa tttcattatg gcaagcttcc59400tgggaaaagc aagtggcctg ccttataaat ttggactcat tgttagaaat tacaagttca59460ttgaataatg aatacagtag tcactgggcc tttagaagtg aagttttaag ttggtgataa59520aaagaggtag cttcatagaa ttccttttgt acttgttttt tttttttttt ttttgtcaaa59580ttatcaaacc ttgctttgga tgtaagaatg agttgcgagg ggagcaaaag ggcaactgtt59640cttcatgcca aaagtaatca ctcatttagt tttttctaaa cattttcttt gttccagggt59700aaataagatt ttcaagccac tttaattata atgaatgatt gttaaaatca tactgaacaa59760aaaatgttat tgttattcag gattattcta ttgagtagga cactcaaaaa cttcagttaa59820atattaatac aagataagag cctaataaaa acagtagaac agttttatac atgttaaata59880gttaaaaaat acatcaatgg ttataataca tttgacaatt taccttgaaa tagtctacag59940tttgcttgtg aaaatgagag ttggaagaat tgcagcttgt gagttactac gtagtagtga60000aatgagggtt atcaaaattt gcagtctttt tgcagcctta aaaactggga catgtttgtt60060
ttccctttga gatgcagctc cttggaagca tatgtttaca atagatacct atgtcataaa60120tatttaaaat ttgatccaat gcatagtctt ctccttcaat taacttcagt atccctgctg60180gaaatctgtg actttttcat ctacactcat agctttactg ataggaaggc tttacgaatt60240gcagtggtgt ttgaaaccac caaaccaccc tctagtagca ctgaaaggag caaattatgc60300aggatttggt gataacggtc tttgtataga gatagtgctt tctctttgat tatgttttct60360ctttgattgt gagaaaggtt gtttttgatc attgcactat ttggtcttca tatgctgaac60420aatatttcaa tttcttgtat ttctttctgc cttgttctta ttgacttcat agcacttgaa60480gtgatttaag atacagccat gtatttgtgc agagttgtct ctgatggtcc accatgtgga60540ttcctttatg cttgttgctc tggagatatc atattccctc ctttctttca aaacacttta60600gttcaagatg atcttcaata tcatcaatac ttaaagattt tcttttacat gcacggcttg60660ctggttttga acacagatgc ttggatatgt ttgagagatt aattaaaaga gtgctttttt60720tttgtattga aaagttcatg agttcaaaag aatggaaaaa cagaacaatg taggctaaca60780catgctgtgg actgaggtaa ctggtagatg gctcaggtct gagcgtgtac gtgttttgtg60840tactaattcc cacatggatc catctaacca tgcagttttc tgcctttatc tagtgtttct60900taacactagt agagatttag cagagataga aaatttgttt tatgctgaaa acattccctc60960gtatgtcaat catgttggaa caaattcatg ttttaaaaca agtgctatag cagaaatgac61020tgtgataaaa aagtttaaaa aggaataaaa acttaggtct gtcattatag taagtgttaa61080ttgactgaaa tctcacttta caagaccatc agattgaagt aaaaaagcac aactatgtac61140tgcctttaca ggaaatgcat aataacaaga gatgagcaga gatatatgcc aaatggaaac61200aaaataaagc aagtgtggta ttgtaaatat cagagaggct gaaatttaat gataatagca61260ataatcagga taaagaaaga cattatacaa taaaattact attaatgaag gagatacact61320gttataaact tttatgcacc aaatatagca actaagcata taaactaaaa tctatgagaa61380
attaaaatct atttgaattt aatataatga aactttagaa taccacttta aatttcaaat61440atgtccagta gaaaaaaatt ttaagagatg cttttaataa aacaatatta gacaaacaca61500tatacaacac acatacatac atgaatatga acataaatat aatattttac agcccttaag61560agaaaatata gcttagtctt agattttaac atataggtaa aaaataaatt aaatattaga61620aaaaatctta gagtttatca aacaattgat atactatgat aaaggtttta ttttagaaat61680gaatggtggt tccttatcag gaagtttgtc accagaattt ttttttcatc aacttttaag61740ttctggggta catatgcagg atgtacaggt ttgttacata ggtaaatgtt tgccatggtg61800gtttgctgca cctattaacc aatcacctag gtattaaccc cagcatccat tagcttccgg61860atgctctccc tctccctact ccccccacag gcctcagtgt gtgttgttcc cccaccatgt61920gtccatgtgt tctcatcatt cagctcccac tgataagtga gaacatgcaa tgtgatcttc61980aacaaatctg acaaaaacaa gcaatgggga acagattcgc tatttaacaa atggtgctgg62040gagaactggc tagccatatg caaaaaaatt gaaactagac acctttctta caccttatac62100aaaaactaac tcaagatgga atgacgactt aaatgtaaca cccaaaacta taaaaacccc62160agaagaaaat ctagtcacca gaatttaata caaaatttaa tggtaaagag aataagcatg62220tggtcataat agcagatgat gaaaatgacg ttttaaaaat ttatcaggaa tttctaataa62280aacgaattac aaaaaacaaa aagaccattt accaaaagca cagctgaagt tttttttttc62340ttttgtaagt gatgaaatac taaaaatact taaaattcat tgagggtata gtttccaaat62400gaaaaaatag acaaaggaca tgaatgggca attcacagga cagcaaatcc aaaagggcaa62460caaatacata aattgatgtg caaataggcc tgatgcaggg cttatgcctg taattccagc62520attttgggag gctgaggtgg gcggatcact tgaggtcaag agtttgagac cagcctggcc62580aacatgggaa aaccccatct ctaataaaaa tccaacaatt agctagacat ggtagtgcgt62640gcctgtaatc ccagctacat gggaggctga agcaggagaa tcgcttgagc ccaggaggca62700
gaggtttcag tgagccgaga tcgcaccact gcactccagc ctgggtgaca gagcgagact62760ctgcctctaa ataaataaat aaataaataa ataaataaat gtgcaaactc attatttata62820aataaataaa tagatgagtc agggaagagt gaacccggga ggcagaagtt gcagtgagct62880gagatcacac cactgcatac cagtctgggt gacagaatga aactccttct ctagataaat62940aaacaaacga ttaattaaat gatacacaaa ctcactggga gtcagaaatg tgaattaaat63000tgaaaatgac atattataca cctaattaga ttggccaaaa taataaaata cccatatctc63060cctaatattt gtggtggtgt agagaaaagt atttccaaat attgctagtg gatatgtgag63120gtactatatt ttttggacag aacatttagc aataaatatt aaaataaaaa atttttaaaa63180ccctcatata ccctttgatc cagaaatccc aaaccaggta tttaggctat agaattaaag63240taccagtatg tgagcataag tataaggatg tttaataact taattattgt tcatactagc63300aaaaaatgga ggaaaatgaa tatccattgt aatagttaac ttatggtacc tgcatataat63360gaattatttt gcagctatta aaacttgtca ctgtttgctg atgatatgat tgtataccta63420gaaaaccctg aagactcatc caaaaagctc ctagatctga taaataaatt cagtaatgtt63480tcaggataca aaatcaatgt acacaaatca gtagcactgc tatacaccaa caaatgacca63540agctgagaat caaatcaaga actcaatccc tttacaacag ctgcaaaaaa aaaaaagaaa63600ataaaatatt taggaatata cttaactaag caggtgaaag atctccacaa ggaaaactac63660aaaacactgc tgaaaaaaat cacagatgac acaaataaat ggaaacacat cccatgctca63720tggatgggta gaatcaatat tgtgaaaatg accatactgc caaaagcaat ctacagattt63780aatgtaattc catcaaaata ccatcattct tcacataact agaaaaaaca attctaaaat63840tcatatggag ccaaaaaaga gccttcataa ccaaagcaat attaagcaaa aagaacaaat63900cgggaggcat catattaccc aacttcaaac tatactacaa ggctacagtt accaaaacag63960catggtattg gtataatagg cacatagatc aatggaacag aatagagaac ccagaaataa64020
agccaaatag tgagaaccaa ctgatcttcg aaaacgcata caaaaaccta aaatgaggaa64080aggacaccct attcaataaa tggtgctagg ttaactggca agccacatgt aggagaatga64140aactggatcc tcatctctca ccttatacaa aaagtcaact caagatggat caaaggctta64200aatctaagac ctgaaaccat aaaaatttta gaagataaca tcagaaaaac tcttctagac64260attggcttaa gcaaataatt catgactaaa aacccaaaag caaatgcaac aaaaccaaaa64320ataaacagga cttaattaaa gtgaaaagct tctacacggc aaaagaaata atcagcagaa64380taaatagaca acccacagag tgggagaaaa tattcacaaa ctatgcatct aacaaaagac64440tgataagcaa aaaagtatat ataagatttc atttttatgt tgcaaataat tgtaaaagta64500tatatttttg catgtatatg ccgaaaatat ggtggaatag ttactacatt ttaaaatgtt64560ggaacatatt aaatatgggg aggaaaaatc gaataaatgt tataaagtgg ggaggggggg64620aagtggaatc aagaatagag aaaaacaagc aagtgataat agaccacaaa agaaaaaaca64680aaatgtttgg gaggcctagg caggcacatc acttgagcca ggagtttgag accagcctgg64740gcaagatggc aaagccccat ctttacaaaa aatacaaaaa ttggcagggc atggtggtat64800gaacctgtag aacccagcta cttgggaggc tgaagtagga gtaatgcttc ttgaacccag64860gaagtggagg ttgcagtgag ctgagatcat gccaccgcac tccagcctag gcaacagagt64920gagacagtgt cttgaaacaa aaaacaaaat gtctaatata tggtggtctc atttatgcat64980ttatgtaaat tagtattctg ctagtcttgt gctttttaga agagaaaaat tgatatttaa65040caattaatag gcttaattat aaatgcatta aaagccctaa taatgaacaa ccttaatcta65100ccagaatgag ttccaaaaat ggacaattat atggaaaatt tgggctttaa aatggtgtat65160tttgttgagg ctacacttgt atcctgcaga ccagagaggg cataggcaag atgctgacct65220tgccttgtct aggaaatact agggatggct ggagggttgc cgatttcaaa aggaagcagc65280aggattatat ttaaatgagg ggtctcaaat gggtactcat gcctgtaatc ccagcacttt65340
gggaggctga cacaggcgga tcacctgagg tcaggagttc tagactagtc aggccaacac65400ggtgaaactc tactaaaaat agaaaaatta gccaggcatg gtggtatgca cctgtaatcc65460cagcaactca ggaggctgag gcaggagaat ggcttgaacc tgggaggcgg aggttgcagt65520gagcttagat tgtgccactg caatccagcc tgggcgacag agtaagactc tgtttcaaaa65580aaaaaaaaaa aattaaatgg tggggggtct tattactctg ctttgccttc tccattgacc65640actggaacaa attgctttga aggttatggc aggtagccat ctctgtatag gaatatgaac65700aattcctacc taactgaagg tatcaatttc taaatttacc aaaaaattct gatgcccagg65760ttttcattcc agagattctg attgaattgg tataagaggt gtgtggctgg ttttctgaag65820cccagagaga gagagagaga gagagagaga gagagaaatt taccctctca ggtttgttca65880gctagaatta caattcattt caaatctatc taaaatgatt gtcattacaa atgattccac65940attgtgctta gtaaccagat gaaacaagag ccaacaaggg ctgcattatt taattctcat66000ctattagtaa actaggacaa aatagagtaa ttaagtaatt atgatatcta aggcactgaa66060agtagggata aaagggaatg tcatcaagtg aatatacatg aggtgagaca cacagactag66120tatagaataa aggaaccgcc cttgacagtg cattggaatc acctggggaa ctttaaaaaa66180tactgatccc cacccccacc caccactcaa attctgatgc aagttgtcct gggcatagtg66240attttaaaag ttacccatga gattctgtta ggtagtcaga gttgaaaacc aataacctaa66300aaggaaatag gatgaaaaaa agtgattcgt gtagaggttc aaagaccctt taagatgggt66360atcattcatt catttattta ttcagttcag gtattcagtt tagtcattct tttcattgca66420ttcaattaat tcaatattta tgaagtaccc actttgtatt tgtccctgaa ttagagtccc66480caacatcacc acttgatgga taaaatgcaa atttgttttg actaatttct ttgtgcctgg66540aaggcatctc ttattctgag tctggctcta ttagaaagag aggcaaattt tctcctcttt66600tctcttctct cttttctttt tctttctttc tttccttttc ttgtttggtt ttagtaaagt66660
gggaagatta ggggattgag aaagaaagag cctaggaaac tttcatttgg tttctactgt66720gttagctacg gattcacatt tcacaggcag aatctcacaa atctgtgaca gaggcattat66780tcactccagt ttacaaatga ggattctgag actaaaaatg attaaggaac ttgtaataag66840taaagccact tattacaaaa ctaggatgta aactgcaaag ttacttcccc caacattttt66900tcttccagtt tctctaaagt caaaaagagt atagccacgt ccccttgcaa atcatatgtg66960tatgcacgta tttcaggaag ttgttctggc aatgttgttt ctttgaaatt tcttcttgta67020tctttaaaac tcacttgaat ttttatttca cccccatatg atgattaaaa tgcaaaaatt67080gggcttaatt tgccattagg aaaaaataat ctgtttctgc cttaagggat gcaactgcat67140tgagtttatc aatttcagaa aatcgtgttg actaaagaga actgactcaa catataaggc67200tcagcatcta ggaaattgct ctgctctgga ttgcaatcac tgaatttcat agatctgggg67260atacaaatgg taacagatct ttttctccgt gcttcttttt tttttttttt ttttaatcct67320tgagacggag tcttgctctg tcgcccaggc tggagtgcag tggcacgatc tcggctcact67380gcaagctccg cctcccggat tcactccatt ctcctgcctc agcctcctga gtagctggga67440ctacaggcgc ccgccagcac acctggctaa ttttttgtat ttttagtaca gacggggttt67500caccatgtta gccaggatgg tctcaatctc ctgacctcgt gatctgcccg cctcggcctc67560ccaaagttct ccatgcttct taaaccctca aatgctgcct gaattaaaaa ggcctctgca67620ttcactgacc agtctcactt aactcactga tgctgatctt ccccccaccc ccatatggta67680taatgcttat gtcatgaatc aagaatctcg aggacaaggc aggtggatca cttgaagaca67740ggagttcaag accagtctgg ccaacatggt gaaaccccat ctctactaaa aatacaaaaa67800ttagcagagc gtgatggcgc aggccgtaat cccagctact ggggaggctg aggcaggaga67860atcacttgaa tacaggaggc agagattgca gtgagctgag atcgcaccac tgcactccgg67920ctgaggaaat agagtgagac tctatctcaa aataataata ataataataa taataataat67980
aataataaca atagtaatct caagtgactc atagtcccta ttagtaactc tcttcatcca68040gtgaaatttt atttttttgg tagtgattct gtgtctattt caaacactca tttggcagca68100ctttttattt ttggcaatta tttattcaac tcttgtaagt atctgtttac tttgcatatt68160ttctgctggt ataagctcta ggaaggtaga aacttagtct gtgtttctaa ctaatatatc68220ctccacacct agcattttgc ctggtagtat atatattggg catttagtat ttgttgaatg68280atcgcagcat aggactttca cagataattt actcctaaaa tatgcttttg acatgtcaag68340cttcactgac cttgaagaaa gcctgaagta atttttagtt taattgattt tgccttttta68400ttgtattgtt ctattcatga tttcatttca gttgcaaaac attctgaaaa cgttttgaga68460gatttgtttg aaatatagct ataagaatgg ttgtccaggg attttttttt tctttccttt68520tttttttttt ttttttttga tatagagtct cactctgttg cgcaggctgg agtgcagtgg68580tgcaatctcg gctcactgca acctccacct cctgggttca aacaattctc ctgcctaagc68640ctcccgagta gctgggacta ccagcatgcg ccactacgcc catctaattt ttgtgttttt68700tagtagagat atgaggtttc accatattga ccaggctggt ttcgaactcc tgacctcgtg68760atccacaggc cttagcctcc caaagtgctg ggattacagg tgtgagccac cgcgctaggc68820ctagggattt ttaaaaaaca aaatctcact caatattcag gattatttat atttttacaa68880taataaaatt taaaatacaa ataagcatca aaactcacca acatgtttag tatcgatagt68940ttctgtgtta ccaccaattc acaagattag gttaagaaaa tatcctttgg ttgtttcttc69000tgtcaagatc attttaggga catctgaagg gtaactgact ccataatatt agatttctat69060gcatttccat tgtcttgtat gttgttactg gtttcaagtc tattttcaaa ttactggttt69120ttaaatcaca ctcaatattg ccagttgaac atgtaattta aaacttattt cccctcttaa69180gttatataaa agataacaaa tttgcttacc tatctactgt tattagaatt ttcagccaag69240cgcggtggct cacgcctgta attccagcac tttgggaggc cgaggcaggt ggatcacgag69300
gtcaggagat caagaccatc ttggctaaca cagtgaaacc ccgtctctac taaaaacaca69360aaaaaattag ccgggcgtgg tggcgggcgc ctgtggtccc agctactcgg gactctgagg69420caagagaatg gcgtgaactc gggaggcgga gcttgcagtg ggccaagatc gcgccactgc69480actccagcct gagggacaaa gtgagactcc gtctcaaaaa aaaaaaaaga aaagaaaaac69540tcatgtaatt ggggagctcg tgatattggg aattagatta gtctcaaacc tgccctgtgc69600atatcgagta ttgagatata tgcaactact atatttcatt catggtatta ttttacgtat69660attccttatc aatcacctgt caaattaggt aattttatta cacacacagg tatttatata69720atttttagtg acacaggaca attatatatt atttcatact atcctcacac tgacagagaa69780gatatttgtt gttccttaaa aaatcaaaca aacaatagaa agcagctgag aatattgaga69840ttcagtcttg cccaaggtca cgtatgctca cacacagcta gaaccagtca cagatctgct69900cttcgtctgg tgctgtctac tctgattttc aaaatagtgg ctcctgttca ctctccccta69960ttttaatttc agagttctgg cagaatggta agaatgtaaa gaaaatggtt cactgctacc70020tctggtatac actttatctt gtaagaattt atggtagatg gtgttgggga acagtgcctg70080catggcaatt cttgcagcat ctctgctgct gtatatcatc ccattttctt atttgccaca70140ttgtaaatca gctttgcaaa tagccactca tacagggaag taacacttta ggctggatag70200tacagtactt tccaattttg tagatgtttt aggaagctat gtctgctgaa tatgccacat70260ttcttatcac tgtcatctca aaaccataat taatattaac cgagaaatga tgatcaaggt70320aatagtctca aaactctttg gcaaataaac aatgctattg cagcacaact ttgttaggca70380ggatgtatat aggtaattaa tacttttagg atatctaaat agctattctg tggggctgag70440gaagaaaaac ttcatcagga gagtggcaat aaaaaaaaat gatgcagtac agcaagatgc70500cgctgaaaaa taatctttgc agaaagcaga acaggcacaa agtacatatt tggagctcct70560tttaagaaaa gttttaagct gatccaactg agtataaagt ggagttgcat gctcagggta70620
aggctctgca gaaagcattg accaggtgtg tgtttatggt tttcaaagct agaactagct70680actgtgccag tggcttttac agcatctggt gggtaggaac cagcatgagt catccgggga70740gcactggact agccggggca ccccagtacc cactaaagag ctgacctagc ctcttgcctg70800gggctgagaa gctgcatttg gtctagatca aggtcctagg gaggaactaa gcaggtggtt70860tgatctgaaa tacttgaact ggcacaacgt caagtaggcc agacaggtag ggcagaggca70920ggcatagcaa gagcaccatg aactggtgac ttagtagatg cctggcctca gttctttttg70980gctaagggct gctctgttgt tctttgcctt ttctgcttcc ctgtgggata gaatttgcag71040atctaagagg ttcaaaaagt tgagaaaagc cctgttacct ggaaaaaata tcatattctt71100agttccctag gaaaagtctt ctgattctga attagaactt gttattgacc tttgtcctca71160ctggtaaaat cattccctgg tgttagaaaa agtgaaattt gtgctaggaa aagaggagaa71220tcttaaaacc acggatgcat ctgtccttaa gcagtaaaat cctaacccga gagaatccat71280gaaatctgca gctctcctta ctttgccctt gactctgtca gctcgtttac ttaaaaaggc71340aatgtggggc agactgataa gatgggttcc ccagagtata tccactgcct cttcaacctg71400gctgcgggtt gacggtttat ataacactaa ctctgaatat gtggaactga cagttgtcaa71460attagtattt atacagaatt tgctccatat gtaaaaccag tcaggctcaa gttttaaaca71520atggacattg gttttatact ttctgatgct ttaaatgcca tcctagtata actgaacctt71580accttggcat agaattatgg taggataagc gccgggctac ttttagtgca cagtcattaa71640gtacctctca cgagataact ttatgattat ccctcaaggg aactgtgggt aagactattc71700ttccttttct ctcctgtcga gttccagtca caaattctca cagagaagag gcttaactaa71760aatttcattt tccccgtaag ttttgtacaa ctctgttaga gcttcagcat ttggaatagg71820ccccaaaacc ccctttaata cattcactga ccaaaagttt ctcttctctg catttacaaa71880atgaacaata agctaatggt atcatttctg ccagaaactg cacaagctga aaatatacat71940
gtttaaaaaa acattttaga tacatctgag caatattgtc accatttgta aacatcatgg72000aagacaatta ttctcatagc aggtctcaat gacagtgaaa tggtcagagc cagtatacct72060gaaagttatg aagatgtttg agaaataagg ctttagtcaa tggcacctac tgaaagattt72120ctgagcgtgg aagtatatac aactaagagg aattaagaaa gatcatgtaa taaaatgagg72180aagaaaatcc tttatcactt ccccaccaga catttttatc attttatatg tttttccctt72240atgtagcact tggtaaattt agaattatat atatgtaagt gagtctttga agaatgcctt72300atttccgcaa ataaagtagg agatccacaa gggcaagaac attgcccatt ttcctcatct72360tgaatccccc atatactgtg tatgatgcat ggagcctgca caagatgagt gttcaattta72420tttttatgaa agaataaatg aattagtgaa agaatgaatg agtctagtag ataattagag72480gcttagacag tcaagaaagt aagtgcaagg gtgccacaga gagtcaaaag agttgacagt72540gaataatatg actgaagagt ttatgctctg tgccctgatt tatagcctgt tgagtaccaa72600tggccctgag tgcccaggta ttgaccatga ccagcaagca ttgtgagacc tgaaggtgac72660tcttttctct gattgtgttg gtagcagcaa gctgttatct tactctggat tctgattacg72720tactatgtat acagtaattg tgtaataggc caggtgagca ttaaacaaag gctgttttca72780tttcttaaac ttcttgtgca attctttagc ataagagatg acaaacaatt tggcagaaag72840tcaaatgctt taaaaatatt ttcgggatag tcattaagat atcattgttg taattcctta72900aagtttatgg taacttttaa ttgtatgttc aataggaaca aatccaagct ggcctatcga72960actggttggt tgtgtaatta atatacataa taaagacatt aaaggaccat cttagctaat73020aatagcaagc ttatcttcct taagtgggct atttttttcc aaaacaattt gcaacataat73080ttatttaggc tagtttatgt tcaccaaatt tctttatgta ctgtctacta gaagcaattt73140gtcttttctt cataggctta taaatttgag ttttaaagcc aattaaagaa aaaaatcaaa73200tgaactcagc ctaatttatt gaactaagag cttttacaga ataaaaaata tatggaattt73260
tatgtcttac tttgtcttta atgactttcc ttttagtacc ttagacttca atgccccatt73320atataatttt tagaattgag ttaatacttt aactaataca tctatattta tcttctgtat73380ataatagatg tgttataagc tataagctcc tctaaacaat atcaaatatg aaatgttcaa73440cacaaacctg tattaaagaa tttgttttta cctcttgttt ggtaaagcat taaaaaaaag73500tctcaatagt tttagaaaac atttattcaa ataccaggct agatgttgag gatatagtgt73560tgaaaatgta atcttaagtt cactgtgtat tgggaataca gataaagaag ccaaggattt73620cattacagtg tgataagtaa tataacagag gaattcacac aatatttaaa gatgagagca73680gagaatagag gcatattttt taacctaaaa attgactttg ttgtcaaaga agattttcta73740taggcaacta aacttaatgc atttcttgaa ggaaaagaag ataccagcca ggaggaaact73800cgtgtgtgtg tgtgtgtgtg tgtgtgcatg agagagagag aggtagtact ttgggtattt73860cgagtatgtg caaagcatgt gcaaagatat tctggcatca aatagcaatg tctcactttt73920aattctgtgt ggtatttagg tttagtaacc attgatgaaa agttggggga gataaacagg73980agacagatca tgaagaaacc tttaaaacat gctaaacaaa tggctcttta ttttaagaat74040aatgtggatc cactaacaaa tcttacacag aatagtcctt ttttttttag gctacatact74100gtccttcaat atatatataa aaataatacg gcctccttta aaaaatgttg aagtgcaaaa74160taatcatttt ttctaagcta aagcaattgt aatctctgat aagattttct gaattaatct74220atcatatgat ttgtttaatt aaagaagtct cctttctttc acctacccct tccccaaccc74280ttagatggga ttattatatt atttccttgc agtcactcag ttgagaataa cagatttagg74340atcagtgtgg aatgtggata aagaaatctc agaatgacct ggggagatct gttagcaggc74400tcttgggtat tgcaggtaag agtgatgtgt gcctgtgctg acatagcagt gataggaact74460gagagaatgg gattggtata agagatacta tggaggttgc atcagtgaga cttggtggta74520gattgaatgg gggatggaaa gacagaatgg ttgatgttga ctgcccagtt tcttgctcag74580
cctattgggt agatggtgac acatatcaca gtattttgaa ggggtatgga aaagaggtag74640aaaagatggt gagttcagtt gggtatctat tgacttagag atagtaatgt gtaataggca74700tatgaagata tgggttggag ctcagaagag atgtctgcta agcaattatg aatctgaaac74760tcattgctga acagatagtt gaagttacag gtttggccat ggtgttccag gacagagagt74820tgactggaat cagaagagta taaatcaaga aactttgggg aaaattccca tatttataag74880gagaaagagg aagataaaac ctgaaaaaaa ctgagaaaga gcaaccatag acataggatt74940caaatcaaga cagcaaaatt ttggaagatg ctgcaagaag taatcacagt gtcaaaagtg75000actgagaggt caagtaagat gaggacctac aaatgtccat tcaatttgga gttaaaaagt75060ccttggcaga cagattgcct catttgtaaa aattcaggtg acattttaat aattttatta75120agcaaaataa tttatcttga agagatgaaa ccaagccaaa ccaaaaaata ctctgatagc75180ataaaagcat ttcctttaca tatttttcta aatgttacaa gacactttgg tcttttggtt75240gaagagaaag gagagggaga gggaacatta tatttatggc attaacatcc ttattattta75300agtcaattat agattttagt aaatccatat attcaacatg acaaaatgtg cccctccaat75360ctatttcttt ctttttcatg gcagtacttg tatttctttt tataaattta aataataatt75420ctgagtgtca ttttctagaa tagcattagc gattctaggt tcataatata gagattataa75480tgtgaaatct aacaccatat taatgctttt ggaagaaggt aagagataat ataacttaaa75540aaataaacaa ttatagcatc ccttatgcag agaggctata ggtttcttca aggaaattag75600taaatttaaa agcatcaagg aagatttatt cccagagcaa ggtttttctc tctgatgcag75660gttttccagt ttgatcctta aacatgggaa gaaacataca tgaagtttga atctggtgac75720aagacaggaa acagaaggga aatacagaga cttaccagtg ttatttaaca gtattgtgaa75780caacaggcca acttctattt caaagtagag cgatcacaaa agctcaaaat agccttgggc75840agtacaggag agcagatgaa gcactgaact ggatgccaag atgaaatcaa tgagagagaa75900
caggtgaaaa attgtcagca agagttacat tttgggccta ggaaagaatg tgacgattcc75960aaagggctac ccactctctg aaacaggatt gtatgaatta tatttcctag atatatagca76020cctgcagtgt ggatggttag gaattttgga gaagttaaat tgattgctta tttcattgta76080cgtcaatgca aacatttttc aatgaataga acatatctac aattaacaga agaaagttct76140agaaaatgta gcactcccta agtcagtgtc ttcttggtga ataagtagat gtgttcttat76200atccttgatc agcaacaccc aagggacaga gacaggactg atgaagattt ctattctctc76260aataagttta gcagagctga ttggagtcgt ctgccgtaga acatccacag agcaacgatg76320tatatatatg tcagtatatc tcagatgtcc tctaattcag attgtgaggg atggaagagc76380ttttgtttct ttagagtcag agggcacgct agacagttat gtgcacaaaa acattccaga76440aatcccccat ggcgccgtgt ctggaaatag taatttcttt gcttattgat ttaaaaatgt76500ctcaatctgg aaaccaatta gaatttttac gtaaatattt cagtaatcta gcattgtgtg76560tctgattcaa gacacctttg aaaatcactg caaggctggg tgagatggct tacgcctgga76620atcccagcac tttgggaggc tgaggcaggc ggatcacttg agcccaggag ttccagacca76680gcctgggcaa catggtgaga cccccatttc tacaaaaaat acaaaaatta gctgggtatg76740gtggaagggg cctctggtcc caccttctcg ggaggctgag acactcaggc atctcccagg76800atcacttgaa cctgggatgt tgaggctgca gtgagctgtg attgtgcccc tgcactccag76860cctaggtgac agagcgagac actgtgttta aaaaaaaaaa aaaaaaaagc aaatggatgt76920ggacacatac aagatttgga aatttgattg cgggcatgac tcagggaaat atgagattaa76980actctgctgt ggaaaatgtt caagtcctga tatttatgtc tataccataa tttccatctt77040gctaaacgtg agaatttttt aaagaactat ataaaagttg cttggaaaag cagcatactt77100ttctagaaag atgattaacc aaatgctaac caaacgttgt caatgaggaa taagtgattg77160ttcacatttc tgtgatcctt tgaaacatga taggaatatt taactactcc ataaaatttg77220
tttcccattt tatatatgtg agagttgctg gaaacaaatg aaacaccatt ataaagtatc77280aaattctctc cttggaatga atcgattttc caccagagcc attgaggcaa ttccttagct77340cctggttgtc aaaacctggc ttcagagagt gacatctttc agaagtccaa ctcctacccc77400tcttgttaaa aaatattcac tgactgcata ttagttagta aataaccctc cctccatctc77460tcactgacaa aaaatcggac tcattttcaa attctttcca aaatgtcatc tccttcctga77520agtcttttct gaatcttttc aaccaaatat actctgtcct tcctctgacc tcacaaacta77580tctcactctt aactttgtga catttatttg tttaatttgt tcatttgcca cactattttg77640taacttcctt gaaggcagag tttcttcttc gggtttgtat tatctatctc attagatcag77700tattagattg atagattgat tgatagattg atacagagct agagagacag agagataaac77760aggtagataa ctcatgttcg aatatcttgt ttttagtgga attaaatttt agagaagaaa77820agcaggcaaa cataaaagga ttttgaaaga tagaagatac tttggccaaa aacatattta77880tcagcagcat acaaatgtgc ttacacatgg aggcattatg gcaacccaaa tacaaactag77940ttcttttttt gtcaacacat ttttcactat tgtcacagta gcttgtttac catatttttc78000tcttgactca cttgcctcct attattgggt cctagaatga tcatgttcct gctggataga78060gcaagacatg tttagaagtt ttgcttatgg aaatcaaagt tgttacaatt tcaaggtcat78120cttatctttg cactttaaat ctactattta gttcgtctta atctttagct tttgtctact78180tccaacctct gaaagtaatt ttgcctttca ttttgagctc catccctgtg tagagtttca78240gatgtctctt ggctctccca gtcctccctc taaacaactc acaaccctgg catgatcttt78300agtaagattc ttcttaggtt tttttttttt tttttttttt tttttttttt attaaagggc78360aaggtgggta ggggaatggc atagaagaac acatttggtt gtttttcagg gtacctaagt78420ttatgtaatt atcatcaggt agctcttgct ctttacatgg tttgatggtc gtttctctgc78480caagtggtct tgaagtcttg tcagggacac ttctgcttca gcaatgattt ctataggaaa78540
gtgaagccca taacattcaa acttgggttt tttatcttct tgattactaa ttagctctaa78600cttccaatat ccacaaataa aacttcagag tcaagttaaa agtctttaat tgattacttt78660aaatttgaag ggtatgcata cttatttcca tggaattgca agatcaaagg ggatgaaatt78720cctgaaagca gtactgtgtc cctcaaatcc tctgatatta actgctctta aggatatggg78780gaaatgggct agtttgggat ggtctgtatc atagctctta ggaaataaaa aataagaatg78840gaggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg78900gatcatgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc cacctctact78960aaaaaataca aaaaattagc tgggcgtggt ggcgggcgcc tgtagtccca gctactgggg79020aggctgaggc aggagaatgg cgtgaatccg ggaggcggag cttgcagtga gcccagatcg79080cgccactgca ctccagcctg ggtgacagcg agactccgtc tcaaaaaaaa aaaaaaaaaa79140aaaaaagaat ggaatagatg cttcaaaata cattaggacg aaggtaaatt acacatttaa79200aaacttagat gtgtgtgaga atgatgtttt taacaaattt taaaaggtga ataagtaaaa79260taaatttaat tttgaaatag ttctacattt ttttgtaaat tatttcttcc atgatgattt79320agagggacta tcaacaaacc agtacaaata tttcataaat aatatctgcc tgttttctaa79380ccaattgagt aatttgttgc acaataagcc acttcacatc tttctgcaag taaaacatta79440gctgtgaata gtaaagacat tacacaatga attagggcac aattaaaatt tgatttaaat79500atttctttag gggagggaac accacacttc cacttaatga aaagaaacat ttttagagtc79560cagaggtctt ttgcttcttt tacacctatt atgccctgac tgcatagggg acaggttcca79620gcagctcagg ctttggttct cacaaagtat gtttccctgg gtggagcagg ctggtgcttc79680agttgaaccc aggaaccttt ctctttggct tctttctctg accattttcc tttatgtgtt79740ttaggaagcc gtctcggcac ttagagtgct taatatgctc aatatgcaca tgaattccct79800tggcaagaat cttgtcctta acttgtttac aacactgcca acagcatgct gggtaacact79860
gtagattctt ccaattttgc catggtaata cttgtgaggc attccttttt gaacaggact79920cattcccttg atgtctacag tatcaccttt cttctaagtt tgcatgtaca tggccaaatg79980aacaactccc tgttttccaa atagactgga gaacatgtat cagtgcctat cctctttccc80040tgtgtgttca tcattttggt gaattactga aagatggtgg ttctggctga aaggctaatt80100ttttaattta aaaatttcta atgattctac ttttaataat ttctaattaa tttctaaaaa80160tcaattgtat agtattaagt aaatttcact tttcagaaat gatctaaatt tgtttttgtc80220taaacatacc aatatcataa tttcagattc agattgattc tgtttagcaa gccatttaaa80280atttgcttgt agttcccggt aatagtatga gaaggcaact tcttcttatt tatttatcca80340aatttgcagt actattcaat tcatacagta tttactcata tcccatttta gttttggtta80400atttctcttt ggagaaatat gggagacaat gaaatctcac tttggaaaag aaaaagagaa80460actaattctt attcagtacc tattacatac caaccactgt gtcagatact ttaatctcac80520aactattctt tgaggttgca aaagttttgt gcatttttat acggtttaag aaataaagta80580tcaagaagtt aagtaactaa gttgcaaata acctaaatga ctcaaagcta atggattgag80640taaacttttg tacattcatg tgttacaatg caaaaaagca atgaaagatt agtaagtatg80700ttattatttg atatcataaa atgcctacta gatattgcca aatttaaaaa atagtacaca80760caaccattta tatgtatgta tatgggtgtg tatacacaca catctgtttt ttaaaaaata80820aagacctaca tacaacacaa gactcacaga atcacataaa ataaaaaaac cacattaaaa80880cagagaaaac tggtaaaagt tgctttagca cttatatcag ggtagtgagt tacagatgat80940tttcattctt ttgtttattc actctaaatt tctgacgatg agtatatctc agctttatat81000tttaaaaaag caacgtatca tttaaaaaat acgtattcca atgttacaca gttgtaaaca81060ttagagctca gctttgaaat ataaggttat attctttcct ctatgatcaa agatagacta81120ctcaggccta aagaaaaaca ctcagatact cccgtgtggg ggctggggga cagggagaga81180
aagagagaga gggaagaaag agtcaaagac acacactcac acacacacac acgcacacac81240acacgggggg gcggggtgga catagagaaa agagctttca tttggctgtt cttgacgtta81300gaccaccttc actctaatta ctgactgtac agttgtaaaa gcccttccca attacatata81360aggatatttt tgagtcctac tggttgctgt tgcaaagcta taaagatctt cataattacc81420ttcaggcagt taaaaattta gagatccaga gaggtctagg tatagattct tttggaatag81480cgggccagct gaaattgtta ggtggttatt attcagtaca agggaatttg gctcttcctg81540tttaaatggc aaatttaacc aatgcacaga ttagaagact ccaaaccaaa tcaattgtat81600atagagaaga acctagaaaa aagaaaggaa tccatttaaa cagcagagga ggtatagtaa81660ttgggcctat agatcacagg cccaactagt aagattgtat tactaagcca aaatcatcaa81720taaaagaaaa taaagccagg tgactaagtt aaggtctagt atgacaatgg tcatgaatca81780acacaaataa tcttggcaca aaagtttcag gacaggctgt ccaaaagcag ctgagtagaa81840gattcaagta aggttttatg tatggtatgt tacgctgatc ttcctccctc gcttacttcc81900ttgctttctc tttccctcct tcttcctatt cctccctccc tcccttcctt cccttcctta81960acttccttct ctcattttcc ttcttttaca aaaataatct ctactgcata cattgtttga82020agcacttata atgatgaata agatgtgtct ctcacctaaa aagagtttac agaatatgtg82080tgttgaggtc ataggttaat atttgtgttt acttattata tcttgagtac tcatttgcag82140tgttttagtt gttcacaatc taacatatgg atttaatgct gaacatgtgg ctcctgctgt82200agaaagttat gggcctttgg gcagaaaccc tactcctgac cttcaaactg aaatggatgt82260cctaaatgat gtaatgtgta tagctaatga tgttatacag tagaactcat ttgtaatagt82320ggtattgaga aactgggcta atggccacat gtagacttag taatataatg agagaaattc82380atgatgaaac tttaagtaag aggacatgat ttttcttcca gtataactga atctttgcta82440ttatgagaaa tattagggtg aaatttaata gaattacaca aaacatattg aactactgtt82500
ggaatagtat ggaatgtgat atcaaaatca tgcttcaata gaatacaagt ttaggcttga82560aatatattat atttcaagtt gaaattcatg acagctgaat aagggatatg gtattgcctt82620ttaatgagct aatttcttcc caattttaag agtgaccaaa ggtcagccct tttggattgc82680acagcacaca cttgtaagaa acccttataa atcatcctta tgttcaagtg caaggcaact82740ataacacaag cccatgtatt aaatcaaaag tgcctttcag aatatgagag agagacgcaa82800atgttcacag taacagtatg ctaagggctt tatgaaatag aaaattaacc ttggaagttt82860ctcagtggac aaggcttaga taaaataaaa aagttattcc tttggtatgc ttagaggata82920ccaaacaatg tagaacaatt tgtattttaa tgtggaagtt gttccgtctt gtttatttct82980gagtgtcagt ccttctgcct tatccccatt attttcaaaa ctgtaaacta catacagcat83040ggctctaatg aatcaggttg acagggattg ctaatgcatt ggaacatttc tgaatgttca83100gagaaatttg aatttagtaa gtgccatatc tgaaaccagt acagaacctg ggggtggata83160gttggtattg gtgggtggtc agaatttgac acccatcccc aaacttcaaa agggatttag83220agaagtattt ctaataagac tgaagttaaa aggatatgac aatgggaata ccaattggtt83280taatcctttt gaatggcaaa ttattattaa gaattagcta gcattaattt agtactttct83340atatgccagg aactgtatta atttatttat atataattta ataactgaat tacttactat83400gtgtaaggat tcttaaaagt attaatgggg ccaggcacgg cggctcacac ctgtaatccc83460agcactttgg gaggctgaga tgggtggatc acaaggtcag gggatcgaga ccatcctggc83520taacacagtg aaaccctgtc tctactaaaa atacaaaaaa ttagccaggc gaggtggcag83580gtgcctgtag tcccagctac tcgggaggct gaggcaggag aatggcatga acctgggagt83640tggagcttgc agtgagctga gatcgtgcca ctgcactcca gcctgggtga cagagtgaga83700ttctgtctca aaaaaaaaaa aaaagtatta atggtcttga cctagtattt ctatatccag83760gaactcatag taataattaa tgacccatat aaagaattat gcactaaaat gtttgcttca83820
gcattattta catagcataa agtctgaaac aaatgtccaa cactgaagaa tgcttaggaa83880aagttacata aaggatatta tacagtcatt gaaatcatgt ttgcagtgaa tgcttaatgg83940gaagatgatc tccatgcaat gttaagagaa aaacaaagta gcacgcaaaa tagtatatat84000aaaatacttc aaaatataat aaacaataaa cattggaact tttataaaaa gacttagagg84060agatacagca aaatatcaat tgtggttata tctgggtaat gagaattata aataatttta84120gtttttaaaa tttatttctg tattttccaa gttttttaca aaaagtttac atcaagtata84180taatttgaaa aataagctta aacattttct gggtgaaaag aattcctggc ttctctacag84240gcagattccc ttcacacatc ttcctgccca actactgtgt cagtgggacc cctgctcatg84300tgaatatttc tttgtgccag tgtttgggtc tccaggctag agcaattttc ttctgggctt84360tggagcattt tgtttcctac ctcttagtaa tccaccccca acagttgact cctggttttg84420gcatccaccc tttcatgaag ccatcctcag gttgaggtgg ttaaaccatt ccattccacc84480attagttgct cactgccaca ctggctggct tcatgcttta gtgaagctag taaaacctca84540agggatgtat caagtatccc aaaatctact taaaaaattt tgggatgacc agggggcata84600tttagccatc tttagctctc agaatttcgg ctacatctct ctaccaataa tcctgtttat84660actgaggact ttactgataa gatgggttac aagaatgttt tcatgcaagt ccctaggact84720cctcggtaaa ttaagggtat gggactttgg gattaaaagt cagttgctct cagagacgtc84780ggagcattat agatactcaa gaagtatttg atgaaggaaa gaatactagg ggtgataaag84840gtagtcttta atatttttac taatcaaaag aataagtatt atttttcaga aaataggagg84900tgggaaagac atatggagga agcagggaaa tcattcagag gcagggaaaa ttgatggaat84960aagtgccgca ttttgggaca gatattcagg gttaataagg aaaattaaga gaatagtgtg85020atatgatatc aatggacatg cagataactg atatcagtcc tttaacaaag gaaattgcaa85080attgtttttt caagagtttc aaagaggtac aatttttatg gcctagacct tctgtggctg85140
actgtcatag gtgaataatg gctgccccaa aatatcaagt ccaaatcgtt ggaatttata85200aacgttatct tctttgaaaa aaaggtcttt gcagatatta caaagttaag gattttgaaa85260tgaatagatt ctaccttgga tgacccagat gagctttaaa taccatcaaa agtgtcttca85320taaaatagag gccgagggag attccacgcc gacacacaga ggagacaaac agaagaggag85380ggtgcaatgt gaccatggag acaaaaattg gggtggcatg gccacaaaac aagaaacact85440cggagttgcc caaaggtgga agaggcaaga gcagatactt ccctggatcc tttggagaga85500ctgtagtcct actgatgcct taatttcaga ctttgggcct tcagagcagt gagggaacac85560attcctgttg ttttcggcta gcaaatctgt ggtaatttgt tatggcagcc ctagaaaaca85620cacacagtga ataaaataac tcttgtgtgg gaaaacagcc tcattctgat tggttgggga85680ggaaagtgat tgccaatagt gtacctgtaa gacggtagaa ggtgaaatca gctgtaaagc85740gtaggaaggc agtggtggta ggtgtctagg agtacggtgg ccacaatagc atctgctatt85800gtaagagcac tggggagtga aggtgggaga ataagagtgg aagggtcact ttcctgagtg85860ccctaatccc tcttttagtt gacacatcag acctagccat ccagatgaga tgacattgtt85920ctatttaaaa gactgggtgg gaactggagc caggatactc tgtggggtta tttatccaaa85980tccggggtta ttattcaaaa gtgcatggct gggcaaatag gtttatgcca tagtttatca86040agacggaaac caaaagaaag aaagttgcca aattaatttt tgggggcttg aagaacagtt86100gtttgtaaag aaatggttta aattacagat taaaaaaaaa acacacacaa aaatccgtgc86160tgcttcaaaa ctcaaactag actacctcca caagcattcc ttcctcaaag ccaccttgta86220gacaccagac ctagtaaatt tacatttgac agacaaatag gaaacttttt catgttacac86280aaaggcaaca ttataatcta gctgtcaggc cttagctcca ttgatgcact gagatgtggg86340ccagatgaag ataattcagg gaatctagct ccagcgagag tttcagggag ccctccctca86400gttagttgat atcccaaacg cttatcacaa aagcaagaga aacttgataa cgacctggca86460
gtggtgacca gacttattct tcctagaaca agaaagtgat attcagagat tgacataccc86520ttaaaacgat caaaagggaa aagcaaggtt ttctttttag aggttcaagt catgctgagt86580ttggtcagat agtgtgaggg gcccagtcga gtcacttgtg agggtatata aaataaagtt86640gggaaacaaa ggaaacgagt gaaaagaatg aggtatttat tcactaaaag gaccaatgaa86700accgatcccc tctaagtgta aaaggaggag tagagattac tgtgcctgtt gtttaaaatg86760tgtggacaga agattatttc tagaggacac ttagtatata tttaccatgg tatgcatcaa86820aggcaacaga attttgttac gtcgcttacc ataaaatatt agaataaaaa atcaatattg86880atgtttctgt tttaaaaagt aatacatgtt cattatttaa aaaaataaac aagtgctgta86940ataaaagtat atagtatgga gggcgacatt ctcagagata cccacttctt ggtgtcagcc87000acaattaact gtttggtgta caaaatcaca gaaataaggg ctgataaatt tgtagatgct87060gtctaatcca attcccttat ttcatagtgg aggaagatga ggcacaaaca gggctacaag87120gctactgagt tactgaagat tgtccagtta gttagagaaa gatgctggtt tgctcttata87180ttacctacag atacagataa ttttattcac cttttttttt tctgttgagc tatcagggaa87240acacatccta gatattcaga accccctact aggttgacta aaacaaagca aggaaggaaa87300ttttaaaaat agcagagggt ctctaaagac agctgcttga ggtaagcaaa tgaacaggtg87360tttatgattg aattattagc ctcaataaat tgaagaaaac accatttttt tttcaaactt87420gaggtaaaaa cacaataaca atagagaatt tatcactctc cagaactttc tgtgttgaat87480acaggagtat atttttagct ttttctctag gaaaacggct tccagtttct gaatcatttt87540ggctaatttt tatatgcttc cgatctatcc tctgcagcac tcccgcaagc tgcttatttt87600gtggcaaata gtagcaaaca actttttatt tttttcagag atatccagaa tttcgccaaa87660tggtgatgtt ttttcctcta aaagagtcct tgtgaaaatc ccttacttct gtctaataaa87720tgccatattc aatatttact ttctccaggg acgattgttt cagtactatg aaaatctcag87780
aagagcaact agagtcattt aacctactct taatctgtcc taatgccatt tctctcttaa87840acgtgtctcc atttttttca gaattgtatg cctcttagtt tttcaaagca gtgagtaggt87900tgagcagaga aagggccaat acagcatttg ttctcctcat actgctgagc atagtcatca87960aaatgtccta agatatgtgt atgaataatc atctaagaat atgtgtatat tctgtgttca88020tatagaacac atttatatac gtacatgttc tctgatacat atagggttct caatttttga88080ataggaaagg gacttggact ttgagatcta tagatttggg atcaaatatc aacttctact88140tcatggctat gtgatcttgg aaaagtcatt tagcttctga aatttagttt tctcacttac88200aaaatgagga taataatgac tatcttaagg tgatgttaca aggattatat atggtaatga88260cataaaaggt ctgtttgata aatgcttgat gtatcagtgt caacaaatgg caattattat88320tttctcatat aatcacatat attttcaaaa aactaaacaa tactgcctga aaatattcat88380catttgccct ttctgtcatc tagaaaatgc tacttctttt agatcatttg caaattgtag88440ctttgttcag tctttcccaa acttacactt tctcccctgc tccatatttg acagctatag88500ctgctctgct attatcactt tctggctcct cttgttcatg catcatttca gattggattg88560taacgtgctc tggaaccact tcaggtattc tgccctctgt gcaattgcct tagaatcaac88620ttctcccaca attagttgtc actggttaca tttttatcgg ttaaccaaaa tgcttagttg88680aacatagatt aggttgtcat gcctctggag agcctgcagt tcagaacttt tttactggac88740actttctctt gtcacttgat gctaagagga acatgtcaac agtgaaactt atctgaaagc88800tgaatatgaa gtaactgata gacttaggtg tcacattata tagtagacag tagtgttgct88860tgatagaata ttgtttgact ctatgccaaa aggcacactg ggttcactat agctgtctaa88920cttttcccat atcagtatgt catttagaag cttgctaaaa atgtagcaag aggccaggat88980tatttttagt tggaaaagct tcatttactt ctcacaaggt aaatagatct ttaataactt89040ctttaattta gtcttgtttt taacacatga aatgggaata aatattcagt gatttgaatg89100
atggattctc tataacaatg aaatatttaa atgctcttac taggagcagt aatcgaccgt89160aacgtttctt tttgacactc acaagtattt tctgttaagt gggagtaatg tttttaaaac89220taaacataaa atcacaaaca tagagcattt tcaatttgaa cttttaatac ttagaagtga89280gcctttattc agaaggctca tagaagtatt ttccttaatt gttgcatgca taaggatctc89340ttctaaatta acattaattt tatgattaat tttgaaacag aaatctaatt tttactcact89400ggcatgaaat gtttcttgga acaggaaaga gaaatttatt tttgtttctt actaactcag89460tcatcattta atgccatctg atattaaata ccatattttc aacaatctaa aatgaataat89520ttacaaaata ttttaattat attgttatga tattaaatat ggtaggctat gtatagtaac89580acaagctcac caataatgaa tttgctgaga ttaactgtga aatctggttg agagatatgc89640ctgtggagga ttatcctccc atggtaagaa ccatgaaggt ggttcattca tttgactaaa89700gctttgagct catgcttatg tggtagacca cttttcctcc atttcttatc aaaaaaatgt89760gtagccagag gaaaacagta ttttcaaata tttcttatag tagattaaga caatagttgc89820tattgtttgg atgtttgttc tctgcaaata tcatgttgaa atttaattcc tagtgtggca89880atgctgggag gtgggtccta ggtcatggga cacatcctgc atgaacagat taatgttctc89940tcttggtgct gagtgaggtt tcactttatt atttcccata agagctggtt gttaaaaaga90000gcttagcacc tcctccttct ttgtcttggt tgctctctgt acatctgatc tctgcacact90060ctggctttcc ttcaccttcc agctagtgga agcagcctga ggccctcacc agatgctcaa90120tcttgaatgt tccagttcca gtcagcaaaa ctatgggcta cataaatttc ttttctttat90180aaattaccca gtctcagcta tttctttaga acaacactaa gcagactaag ccaatagctc90240ttctatttcc tgtatgtgta gtgcttgaga atagatcatt atgtagcaaa aattcctgat90300ctttgacttc accagaactg acggaggtgt attttgttgt tgctgttatt tttctccctt90360taaattgtct aaaggactat ttatcaatca atttctggcc atttcaaact tgtcgtattt90420
tactgtatgg gtaggtttta gtcaggaaac cagaagccac tctggatatt cagataggaa90480gggtttcgat acagtaattg taggtataat cattgttagg gctgcagagt gaagatcagg90540aaagtctccc tgttgagtag acctacagag cattctcaaa agttcatctg gaagctgctg90600tgaatcttaa gaatcaacat tcctgctgcc tgagatactc aaagtggctg atttgaaagc90660tgtcatgcac agaagctcat gcctgcatgt gcatatttcc ttaattgttg atagaaaaga90720atgctttttt ctgctttgat acccttacta caagcttgct tgtcatttgc agagtaatct90780gtagccatcc agttaaatgg gtactgggaa gggagttttg ggtttctctt tgttgaagta90840gacaaaatga taaaacaggc acagtaatga tgtcaagttg aagacaaatc tggcatagcc90900atgttttgtc aacctagcat tcgtatatac tcttctaccc acattctaac ttcaaaaaca90960accatccaac ttcatgcttc cacatgatat gatctaacta tgtcttatcc agccatatat91020acatatacat atatgtatac actctctccc tacaggggta gacacaaagt tctataaatc91080actgtatgct attttggggt gatgttcatt ctttttctaa ctcagttcca attctccttt91140ggtatctttt aacttataga ctaaattata aggtaaatct ctattaatac acttcgcatt91200agataaaaga tgaggatggt ggcaaaaaac tggttaatat atgcaactat gtacatcata91260aatcagaaaa ggaaataggc ttagctttca catgcttcgt ttctacaagt gaataagagg91320ccataattgg tctttacgat tttgctttct ccctatccat ttgatttgtt ctcagtgggc91380gcgttatctg gtcatggttc ttcacttgat gggatgatgc aaaacctcat ttttgaaggg91440ctagagccac tagtagcctt gcttttttgg gttgctctac tcctttgcta accttttaca91500ctagatatac aagtactgag gggcaatcca gagaatcctt tgaatcctct ttgcctttat91560tatgcagcag caactctatt tctccttgac aatcaatatt attcactccg gttagtacag91620caagcccttc tttgactgtt gccttagtgg catgaagaat tcaaagtgat agtttaaatt91680tcacattcag tagaatcatt gttaggtcca ctagtgtaag cattcatttt ttagaaatta91740
agtcctctaa acctgcagag ccaaaagtgg ttaagagaag tgatatggtt tggatcttta91800tacccaccca aatctcatct ggaattgtaa tccccaggtg ttgagggagg gacctggtgg91860gaggtgattg gatcatgggg atggttcccc catgctgttc ttatgaaagt gaatgagttc91920ccgcaacagc tgatggttat aaaagtgttt ggcagttccc cccactttct ctgtctcctg91980tcgccatgta agaggtgcct tacttcccct ttgccttctg ccataattgt aagtttcctg92040aggcctcccc aaccatgcag aactataagt caattaaacc tctctccttt gtaaattaca92100ttgtctcaag ttgtatcttt agagcagtgt gaaaatggac taatacaaaa agcaaatctt92160ttgtgattgg gtctttaaga ataacagaga gaggaaccac tcccattccc acttcttggc92220tcctttatcc atgtcttctg gccatgggaa aagatagtgt catgttgtca tattgtttgc92280tagttcagaa catatatgaa atctttcagg acagcacata gccaaacaag gtattattac92340ttagccagca cccaaaatga gtttttaata gggcattcca ctgttatgtc aggcaggcca92400acttgaggtg atgtggtaca ctgtaagacc aataaattct acagatgtga acatttccct92460cattctttgc tggtcaatgt gttctttggc caggagcaaa gttatatggg catcattaaa92520gagaatcagg ctttccatta gcctgtggat actggtactt tacaaaggca gagcagacag92580ggatggcaca ttcatatcta ctgtgtttat tctggtaaaa catgctgttc tttcttccat92640gatggaggta gtcaacatgg ctagcagatc ccctcaagaa tagtgccaca gaaggaaatc92700agcatcaaac tcagctgaca acatactatg tttttagcaa ctgtgatagc tagaatagtc92760ttattgaaga gaagaccctg cttttgagcc catgcatagt ctctatcact gacactttga92820ccattttatt tatgagccca ttggtcaagc tcaaatggct gggaagaggg tggctaatat92880tcacagaaag cgttatctcg actttattat tcgaaaaatg ccttgcagtt gaagcctgtt92940tgtgagcaat tacttggggc acaaaaaatt tcaaactctt accattccca gaggtttacc93000atttcttact cagacctttg tgttatcaat cccttatttt attttcttca aaatccggag93060
aaatgagaaa accactttcc attgtccagt gtagatatgg catctctttc caaaaaagaa93120aaaaaaaatt gaatgcagtt ctgcccacta gaaagatttc ctttttcccc aatccttaac93180ggccattaca tagtgggact gaaatgctac atggtacaag actattgtgt ggacatatct93240acaaaccagg actgatttgt tttacctcag tcacttgatg atgaactccc cctgaggtcc93300caaatgtggt gtgtggtata gttgtcaatg caagcttttg atgccaaaag ttcaaatttt93360gccatcagtt caaattctac cccatatctc atgtttctac tctggctggt gtgaagggca93420acttatgcca aacttatgtg agcttgctga atttttctct atagcacaac acacctgtgc93480tttcaggact aattgagctc agttgcacat acgccacttc agtttgataa tggaatgctg93540ctatacactc tttaaaaaat taaatcaatg ttattgagat ttaatttaca taccaaaatg93600cattcatttt aagtgcagaa tttgatgagc tttggcaaat gttctccctg tatgaccttc93660acgaaaccga atatatagaa tatttccttc attcaaaaat tacccagtgc ctttttgcag93720tcagtacctg cacttattcc tgccccaaac aaacactgat ctgattttta tcactataga93780ttggttttgc ctattctgga tttttacata agtggaatca tacagtgtat agtcttttat93840gcctggtttt atttcactat ataaagattc tgagattcat ccatgctgtt gcgtatatca93900gtagttggtt ctgtttcact gctgagtagt atcccattgt ttgaatatat cacaatttgt93960ttacccatca ctgtgttgga tatacttgta caagttcttt ttttttaaat cttttttttt94020attatttata ctttaagttt tagggtacat gtgcacaatg tgcaggttag ttacatatgt94080atacatgtgc catgctggtg cgctacaccg actaactcgt catctagcat ttggtatatc94140tcccaacgct atccctcccc tcccccaacc ccacaacagt ccccagagtg tgatgttccc94200cttcctgtgt ccatgtgttc tcattgttca attcccacct gtgagtgaga atatgtggtg94260tttggttttt tgttcttgcg atagtttact gagaatgatg atttccaatt tcatccatgt94320ccctacaaag gacatgaact catcattttt tatggctgca tagtattcca tggtgtatat94380
gtgccacatt ttcttaatcc ggtctatcat tgttggacat ttgggttggt tccaagtctt94440tgctattgtg aatagtaccg caataaacat atgtgtgcat gtgtctttat agcagcatga94500tttatagtcc tttgggtata tacccagtaa tgggatgggt gggtcaaatg gtatttctag94560ttctagatcc ctcaggaatc gccacactga cttccacaat agttgaacta gtttacagtc94620ccaccaacag tgtaaaagtg ttcctatttc tccacatcct ctccagcacc tgttgtttcc94680tgacttttta atgattgcca ttctaactgg tgtgagatga tatctcattg tggttttgat94740ttgcatttct ctgatggcca gtgatggtga gcattttttt catgtgtttt tggctgcata94800aatgtcttct tctttctgta aacaagtatt actaattttc ttgggtaaat aagaattaaa94860tgactggttt gaatgttctg ttcatgtttc gctttacaag ggactcacaa aatgttttcc94920aaatgatggt tgattattcc caccaacatt atagtagagt tctaattgct ccacattttt94980gccagtattt tgtattgtca gacttttaac tttagcaatt tctaacgggc atttggtgga95040cttaattttg atttttctgt tgattaatga tgtttcatat gcccattagc aatttatata95100tctttctatg tgatgcatca gttcaactct ctgtccattt aaaatttgat tgtttttctt95160attatttagt tgtaagaggt ctttatatat tctggaaact aatcctttgt cagaaatttg95220tactgtaaat gtttactccc agactttatc ttgccttttt atttttgtca aagtgtcttt95280caaagggcag tcatttttaa tcttgatgga gtacaagcat cagtttttct tttacgttca95340tgctttctac atagtatgta aaaataacac aaaaaacaat ataaacagta tagcaaggtc95400acaaatattt tctactatat tttattctag aagttttaca gttttaactt tcacacttag95460ggctatgatt taagttaatt tttatgtatg atttgaatta agcattaaag cttattttta95520ctttgctatt tttatctctg gtttgagtta ggtcttcttc atatcatcca tgtttctatt95580taaaatgctt aatatttcct ctattaagct taactatcct aacttaactt aactatccta95640acttaactta actatcctaa atatttaggc agccaacatt gggccacata aaacaaattc95700
ttagagacct ataaagagac ttagataacc acacaataat tgtgggagac ttaacacctt95760actgacagtg ttagacacat cattaaggca gaaaactaac atagatatct gggacctatt95820ggttcttgaa cacctggata gagttgtaat aactgtttta atgtctttgt ttatatgttc95880tatcatcttc ataatttctg ggtcagtttt gatttaattt tttctcttcg ttatgagtct95940tattttcctg cttttttatg tttgtatggc agactttgtg aaatttacct cattgagtga96000tggatatttt tgtattacta taaatgttgt tgagctttgt tctgggacat agttaagtta96060ctcggaaaca gatgggttct ttcaggtctt gaatttaatc tttgttaggt gggattagag96120cagctaattt tgtcacgcta ctgaagaaaa gccattatgc atatactact caatgcccca96180ttttccactc tgactagtgg gtagagaaac tattcttggc cctgtgaaaa ctctgtaaat96240tttctcctct aatccttttg ggttgttctt tttccatcct cagagagttt cctcacagaa96300ataccctgat taatactcag ccaaagcctt gagggaaggg agatcctgtg aagatttctg96360aatctctgtg taactttccc ctctggtact ctgaccagca aaatgtagct ttctccaaag96420agacctgagc agtttgtcag ggattagagt atactggctc ctgagtggtg ttagccaggg96480aaatgaaatg ttttgtggtg atgtcaatca attttaaggc atcatttcct cattgtcaga96540catatctctc acataggcaa ggaagctcat gtcagctgac tagacatcct ctctccagga96600caatggtgga gattccctgt gaatctagcc ctcttggtct ccgtttcctt ttgttgcatg96660ccaacatacc cctgcttgat aaaccctctt tcttttgtgg taagtttgta gctctctcag96720tcccagtgac attacaatct ttgctaatta gtcatctcac ttggggtttc caaaactctt96780tattcacaaa tactgatagt cctatgagtc attcttatat atgagtaatt cagtaatttt96840gtgttgattt ttaccagttt tatctcaaag atcaatttca ttgtaaatgt tgtgactata96900attactgtga attaagaatt tttgaacata ttcctattta aaaaaaaatc tttgctagga96960ccatctatct tatttgtatg agctccttta taatctagat ttttgggtat tatttatttg97020
ttaatatctt ctagtttgac cttgccctta ttttggttct atttcattgt ccatagaatt97080aaaataattt tttttgtggt ggattggtcg gtgaggggag gcagtggcag acagggtctt97140gctcttttgc ccagggtgga gtgcagtggc tcaatcatag ctttgtaaca tcaaactcct97200gggactccat acatgcacta tgactggcta attaaaaaaa ttattttgta gcagtggaat97260cttgctatgt tgcccaggct ggaacagaat taaaattcta atatagtaaa aagtataaaa97320tctttacatt tattgtttct tctctttaat gtatacgaat gaattaatat ttaatctaga97380gacctgaaaa gcattaaatt ccattttctg gtagattttt gaatatatat tttatttttg97440tagacatatt agagtgttgt tccgtctctc atatttttct ccttcctgac tactcctctc97500atcacttggc taatccatag cagcatgggg gtgggtccat aatagccctg ttggcacaat97560ctgattcttc ctctttgatg atggtttatt ttaatccagt gaccatctga atcaagatgg97620cctaattagc attattttcc tgggacttta aatctgggct gtaaaattta aattgaaaac97680aaggagagtc acttgaatga ataagatgta atcttaggac actgtagaag agatatctta97740gttatgatat cactggggtg ttcagagaaa gaggtgaata aatgaactta atgctcagta97800agaagcagaa gtgagaggag gaagggaatt tcctgggatt tttatgtctt ctgcttccta97860gttccagtgt ttctctaaaa ccagcctgca tttctgttct tggtcattaa taaaatgtac97920ttatatcttt ataataaatt ctctctttca cttactttag ctaaatttag tttatagtac97980ttctaattca ggagttttaa ctaataaaga attcaagttt tttccctttt ttgtaataag98040tttggtgtaa gctgtcagat ggagtatcca acattcaccc taagagtagg aactagataa98100attatatacc accttctggg cagcatatga aggcagttca caaaagaaag aggctgaggt98160caaggcagaa gctagttttg tatattacta ccagatctta taatttctaa gacaaaagaa98220attaagcttg agctaggtta gaaaaccgtg ggagagactg gttaagtatc aatacctagc98280ctggagaagg ggcagacaca aaatggaaga gtaataagag aagactggaa ataacactta98340
gttaaactag ataatccata cagaatcaat ctagaaagag tctcatgatt aataagttta98400gttaatcctt tatttttttc atttagaagc tatataggca tagggtactg gacaaaaccg98460gcatatacag cagaaaccaa ggcaaacaca gcccttccat tatggagctc acattcttgt98520gggatggaga aggaaggtat taaataatta agtatacatt tattcattca ttattactgt98580aatgagtact gttaaggaga accattaaag tttaagctga aggaacttga ccaggtctgg98640gtgacaagga atgattcttt aagaaagtga aataaagtat ctttgcatat attttctagg98700ccagatgttt aaaatagtag acttgttcca gtgggcatgt ggattttttt ttaaaatcac98760tttataatta cttgtaacaa aaactggtag aaatgcaaaa gtgtatggat ttaaatttct98820gtgttctttt ttttatgcct ttgacattaa ttttcttctt gaaataagtg ttagtcatgt98880gacttaaaat gcagaaaatg atacacattg tctagctttg tcagagggat gcagtgagtg98940caaagaatta tcttgcctaa gaaatctaac atcctaaatg gaaaggcttc aaatatcaaa99000taaacccgat gctactttat ttgatacctc cttacaccat ttcatttagg cttttctttt99060ttctgcttcc taactcacat gctcagactt ctcgaaacct tcaggcactg ggaaggaaaa99120gagaacaagg aaactagaag attttaagca tgagctatgc accaggtcca ataggaggtg99180cttggccatt ttgggctgca tctttagcat tagaaatcca ttcttttcct caatgatctc99240tttatgtaat tctccaacag aacagagctt tctcaccaag gccagggacg tttggagtta99300ttgtgtggat ttcagggggt cagtaaaaac ttggaaaata tatatattat atatttctac99360atttctataa tttacaatca tatttaattg ttcttataaa cttttatttg taaaaaatat99420gtttagctta atgaacaaga cacatagagt tagtttattt tgttattact tgctattact99480gtactattta gaaaaggagc ttgtaaatgt caatttcttt tcctattatg catagtttta99540aaatgttaag gttagtagag taaataatat tgtttaacta ctcagtatgt tgtaggcaga99600ataatggctg acaaagatat ctacctcctt atctctgaat ctgtgaagat gttgtcttgg99660
cataacctca tggcaagggg gtgtgaggtt gcaggtggaa ttaaggttgc tgatcaattg99720acctcagaat aagaatattt tcctgtatta ttgagatggg tgtaatgtaa acacaaaggc99780ccttaaatat agaagaggaa ggcagaagga ctggagtcag agttattcaa tgtgagaaag99840acttgccagt ctgtcgctgg ctttgaagat gttgatgtta ggagaccaca aacaggtgtt99900ctctagcagc aaacaaaggc aagaaaacat tctcccctga agctttgagg aaagtataca99960gaaaacacct tgattttagt ctagcaggac ctattttgaa cttcttatct ctggaattat100020aaggtaacaa atctgttttg ttttaagcca ctgaatttga agtggcaaca agaaacttac100080taatactatc aggtaggaac attagattac ttttattgtc cacacattgt gggccaagta100140aataattaag tactttacac acatgtattt ttagttctat ctgactgcag aatatacagt100200cttaaccatt gtgctataca acctcttttt taaattaata attcaatgaa tgattgaaat100260acggaacatc aagtctgtgc tcatttggag cacatacgaa gtactcagca aatgcttata100320aatgcttatc tgaagagtgg ctttttggcc cataggaata ttcagcaagc cagagttatt100380ctacctccct ggatagaggc gtcatggctg gagcaacttt gagcttagca cattctatct100440gagctgttca ttacattcat catttaagat atactcaagc ctttgagagt ttgtttctta100500caattctgaa aatatgaaga tatatgaacc tcctagtaca ccctggtgaa tcatcttaat100560cagggtgttt ccctcaaggt attccaaaca gacatttttt ataatatgag aaagtgaaag100620catattgaac ctaaggccaa gttatagatt ccctaaaagt aagcatcata taaaacaacc100680gatccatttt ttcttcaact ttccaaactt gtttttatcc atttgcttga aatgttttct100740ctcttgctct ataagtatgt tttgtgtagt gcctgattct ccctatggta tttgctttcc100800attaacttcc tattgatttt cagttgtgtg tacacagtac tgcaggaaca taaactgcaa100860acaccagact taaagaagtc cgaactctaa ctgttttatc ttggtgacac agtactacaa100920cgtgaatatt acctgtggcc tcttttaaaa aatgtattta aaggcagttg tgacaagtag100980
ggtcaagtct gaataatgat gtatataaat tacagtggaa aaatatttgg cgtctcagga101040tgaaggatgt tcaagttgaa agggcaggtt ggaacagata aagagcagtt tttgaaaata101100tggcattaca gaaggtgaag caaagtataa gtcactgtaa aaagaaaggt accaaaagat101160gacaaaagtg aggaggagtg ggaaggaagt aacacacagc aagttgatat gacactcaaa101220aaggaatacc gtttttgaaa caagtgaaat ttaaagttat cttaacttaa tctgatgaat101280aatttctcta acatttaaga gcattcacgt ttttattgtt ttgctttata gtaagctcgt101340ccaactggca gcacacaaac cgcatgcagc ccaggacagc tttgaatgcg gcccaacaca101400aatttttaaa ctttcttaaa acattatgag ttttgccaaa agcaattgca acaaaacaca101460gaactgacaa atgggatcta attaaactaa acagatacag cacagcaaag aaactatcat101520cagagtgtac aggcaaccta cagaatggga gaaaattttt gcaatctacc atctgacaaa101580ggtctaatac ccagaattta caagtcagga aacaatagat gctagcgagg ctgtggagaa101640ataggaatgc ttttacactg ttggtgggaa tgtaaattag ttcaaccatt gtggaagaca101700gaatggcgat tcctcaagga tctagaacca gaaataccat ttgactcagc aatcccatta101760ctgggtatat acccaaaata ccaaaatagt attctactat aaggacacat gcatacgtat101820gtttattgca gcactattca caatagcaaa gacatggaac caacccaaat gcccatcaat101880gatagactgg ataaagaaaa tgtggtacat atgcaccatg gaatactatg cagccataaa101940aagaaatgag atcatgtcct ttgcagggac atagatgaag ctggaagcca tcattttcag102000caaactaaca caagaatgga aaaccaaaca ttgtgtgttc tcacttgtaa gtgggagttc102060aacattgaga acatagggac acagagaggg aacaacacac accagggcct gttggggggt102120ggggaggtga ggggagagaa cttagaggat gggttagtag gtgcagccaa tcaccaaggc102180acatgtatac ctatgtaaca aacctacatg ttctgcacat gtaccccatt tttttttgga102240agaaataaaa aattgtgatt tttttttttt tttttttttt ttttagctca tcagctatca102300
ttagtgtttg tgtattttat gtgtggcaca agacagttct ccttccaatg tggcccaggg102360aaggcaaaag attgacacac ctgctttata atctcaaaca cagtagcaca ctttgaagat102420cagagagaaa acacctaact tcatcagtct tggttgtgtc acctgtaaga cagagataat102480acatattaac tcagagagtt actgaatggc ttatgtgtat gtagagaaac tagtaaaggg102540cctgtgtagc ttacatatat ttttagaggt gataaaaata accaataacc atatttataa102600tatattgaag ttaattgaaa tgaaaaacaa taaattaaca gaaaagatta gtcataaata102660aaatgagttg aactaatcaa gcaaaaaaca tgtgtttaat ttctttcaat tattttatag102720attttgactg aagtccacag tgctgattaa atttacatct ctattaagaa gcattaataa102780tacagaagaa atagacaagc caaggagatt gatggcagac ataggattac tttaagttgg102840tgttctatga aaacaatctt aaattaaaat attgaagtgg ggttccttta tattataatc102900tcatgtttca caaatttgtg agtgtatgat tgtactgagc taaaattgaa attgaacatt102960ttttctgttt tctatatcaa atcgataaca agcaattttc tagaattttg agattgtatt103020cctctttcat gagtattttt agaaatggaa ctaagttata aatataagaa aattttgtca103080cattagtgaa aaatgtttac ataaaagacc tgaatttcgt gaagaacctt taaacaatgt103140tcatctccat aaacacaatg tctgctctga aacttctttc ttattagagc caggaaataa103200agaaaggtgt atttttggag gaaagataaa ttgcctgtga tatcttagct ttatgccttt103260ttttcttata cttcatttat actaatgaga attttctatt tatcttttat gagttgattg103320tttgaaacac tattttgtta tttttaccat attttgtttg gggtattcaa gactcttaag103380caagaagttt agttactgaa tattttatat tgatctagtt tcttttcttt ccaacataaa103440gttattttta attttttaat ttttttattt ttattttttg agatggagtt tcactgttct103500tgcccaggct ggagtgcaat ggcacgatct cagctcactg caacctccac ctcctgggtt103560caaatgattg tcctgcctca gcctcccgag tagctgggat tacaggcatg caccaccatg103620
cccaattaat tgtgtatttt tagtagagac ggggtttctc cgtgttggcc aggctggtct103680caaactcctg acctcaggtg atccacctgc tttggcctcc caaagtgctg ggattacagg103740tatgagcttc aagtacaagg aaataatgct cagttgagac tgagttgggc tgagtgggtt103800tttgattaac tgtggtctgc ctgaaacaga aacagtgctc tctgtagcaa atgtatcttg103860aaggactgac agctatacct cctgttgttc tgttcctatt cttacactag tttcataagt103920atctataaga taaatagaaa attatcatta gcataaatga tatataagtt ccatttctaa103980ataaacaaat tattttaaaa gaagaagttt tttttttatt tattgagtgc ctattttccc104040agtcttaccc tcttccagga atgtactcct agttgggaaa aacatcgcct cttgataggt104100tacttgatat tgctatagta ttgaggtctc cttctagatc atggttcagt atagcaggtc104160atcatttttt ctgactggtg aagagaaagt ctagattttc aagtaccttg gaagagaata104220gatatgctac cacctgtggt agtcctgtta tttgatcagg gcttagctct tttcaaagga104280actttcctta agaattctgt ctcttaatac cacttctctt gatgactggt tcaccttcca104340tgataccgtt acatcagagg agagcctgga agaattgggg tggattttgt gtgcatgtgt104400gtgtacgtga gcagtgcatg attcttattg gcttgtttcc tcataattca gctaaaggaa104460agcgtatggt ggcgttgatc taactggtgt ttattatcta ccttatattt ccaagaaatc104520agaatattct cttgagttcc atttaccaaa gtaagtttta aatcatccta atatagagcc104580aaaacatagt tacttttcaa aattgcaatt ccataaattt tagctttatt ttccaagatg104640agagaaacaa tagaggaaaa ttctcactca caacctaact cagttatcaa cagaacattc104700aaggctggat ctcctaatca acattgaaaa agtatcccct acattaggaa aatactctgg104760ttctgtcttt acttcatact gggttattca cagattggaa aggtatataa gtatggcgat104820tgaatctatt cccttcccca catatccctc cctttgtagt gaggtcaagc ttggctcttt104880cactgtgttc atgtcagcat tttgtgttag aaatttacga tgggtgtggg ggcattacag104940
tgcattcaac atttttttca gtgccttcta tttggaaata tggtgacatg tgcagccagc105000actgagtaaa agttttaatg ggaggggaaa ctagtataag gataggaaca gagcaacagg105060aggtgtagcc gtcagtcctt caagacacat ttgctacaga cagcactttt tctgtctcag105120gcagacaaca gttaatctta agttagaaga agaaagaagc agagctgatg caaaaaaata105180tatatatatg gagaaagtta agctgaatgt tgtagagcta acactcaata agtatttgga105240atgttagcag tacaaccttt attagcagct acaaaaatca gactacatag ttttttgata105300acaagatgac caattcaagg tgatacagag gcttgtgctt ggagaaggat gtcttgtaga105360ctattgacca atagggcaga atttcccttt gtacattcat ccctgttcag gtctaacttg105420catcctttta agcacggaca cctgacccat cacacccgca aaagtggata agatcaatct105480caagcagtga acttacactg accaagcaca caggaaatgc atataaaagt agattcctca105540aggccacatc tgaccagagt attcattatt tgttacagaa gactcgggaa agcattgaat105600ggctatctta taattgtttt ttcctcccca tctgaagctg cagacaccat ttgaaaagtg105660gctacatccc agcctatgat tgttctcagg tggcattttt gtttttattt tctaaatctt105720gatgggtacc tcactgttat tcccacatat cactcataat atttatatta tatactggta105780attgaatgtg ggttccatat tctacattca tttgctagac aaataattga gattctactg105840tatgccaagc actggagtaa tctgttaatt ggttaattca tttattagtt tctttaagac105900atactgtatt tactatgtat tggggactat gttagaagct tgaaatatca cagtgaacaa105960gttagaccat ggctactttc aaagtgtcta tagaagaatt gagaaatcaa gtgaacaatc106020acaatacttc tgataagaga taacacagag gaggtaatag ggttttattt ttaaagaaca106080atatataaat atagtggctt tggtcttgta aaatttagtg gcaatgtaat tgtataaaac106140aagggaaccc aagtggataa ggtaggaaat caaaatatta gctagtagta aaataattaa106200atgacattct ctggtctgga aattttgcca agtcttttca aataaacgaa gaaaacaaca106260
aaaaaaactt actttggttt gtttcctaac aagtcaaaag gaaaaccaca atccaacaac106320aatgcaagca acagaaaatc tttaaataat gacgctgaaa ttatcttata actttaataa106380gtaaaagtaa aaatatggaa ataaacagaa gtttggcaga aagaacagat acaaaaattt106440caaaactcag gagaaaaagt cgagatcttc atgaaacaaa gctttaaaag agaaaagtta106500atgttagaaa accacacaaa agtctaaaag cttagaatgt tcagatccct aaagaaataa106560ggagagcatc atatagattt tatggggcat tttattttca caatagttga tactgaaagc106620aatttttttt ccaaagagaa tgtgccacat aacaactagt aaaatagcaa aaacaacagg106680caaaattgga taaaatactc cactttctag cagtccagga gttggccctg taatctgtct106740tctagttttt aacttagccc atccctgact gtctcatata acaattggtt tgtagatgat106800cccatcattg agtagtttag cgtctctgaa tcataggcca ggtacagcat tcaaacttac106860ctaaaaacat cactcttttg gttcttaaaa aatattttgt gaaggagatg ccacaagctt106920tcccttagaa gccctgtgga aatcatctaa ctggtgggct attattagac acattatcaa106980agtttctgct tttttacaag tctcttctta atacagtact agcacatgat gccaacagcc107040catgttatta tcatgtcatt ctagtgcttt aactaatagg tccctggaag gagaagaatt107100cgtttattcc tttgggatta tatatagatt ttctttctta attttatcta cagtgtaaac107160ttatacccag atcatgtctt ttattttgta ttttatgtag caccctcttt gcctttagaa107220aaggtttaga agagacaatg aggaaagata gtttaagggt ggtagaaata agttgaattt107280gagatttgag atggatgtga aagggtttgg agaggtagtt gctgaggaag gggcaaagct107340gggactttgc ctttggagca ggcttcttgg acatgcagaa cagtatcttt gtcagagaac107400attctggacc aggaaaactg ggaacattaa tctagattag tacaggactt tgaacatagc107460tgtgactacc tgacttgtaa attggcatat ctgtattttt ctgctgtcct gagttagtta107520acttcgtatt ttaaaatact catctgaata tatctgctac ttttgcccac ccagaaccca107580
ttaccttttc ttcagtgcag cactgttccc tccccacctt ctttggaaaa cgatgctgct107640ccaaccttta gggcttttgt tttggaaggg cagaccacca acctagatca agatgtagct107700gtcgtccagg cctacccaat gaccttattc aatttccata cctacaaagc atggttgaga107760agaggaaaaa aacccacact tttcagaggc aatcctaggt ttgaactttt gaaaaggagg107820agctctttcc actgtggtag ttgaaggtag agggctgcct ggagctgcca gtagccatct107880tgccactctc tgggataagc ctgaccgaat aaagtccaca cagaggaaag cagaactgag107940agaaagagag ggaccaagtc cctactgatc tcatttgaca cactcgatct actgccttct108000gaacatttct tgagcctata gattactcta cctcccttat ttcccataag tcaccatgac108060ttgccttttt ctgttacaac caaatcagtc ctaggaaata aaatgtttgt tttgcttcca108120cacccacagt ggggcttggg agcatctgta tttcaaagct gagaattctc cacagaatcc108180agttcccttc tatcttgttt taccttctga ggagaggacc atgaaggcag cgtcaggcac108240acgacacaaa tggcagctgt gtttcatctc ttctgtgcag atagcttaat aataaatacc108300tccttccctt tttagggaac aaaatagttt tattttacat agaaatttct tctgtagtga108360gtagcagtga aacgctaata tttattaaag agaaattgcc actgataccc tttggtgtag108420cccaagagga tgtaagaaaa aaaggaacaa atggcaccta cactctataa gctgcctaag108480tggaatctta atgtagaatt tgttgctttg tagtcttctt ttttttttta tctagcaaga108540ctagtgttac agaggatcac ggacattagt cacttgttct tgataacctc tgaagagttg108600gataaaagaa agaaactgcc cccagtgaaa agggatgatc tgcaatatct gaagaattat108660ttctgtggaa gacaatgtta ttacaagaca ctgggatatt atgactattt tggtagctta108720aagaaaaata aattcataat actagatatt aattatattc gatgatatac ataatttata108780atactaggat agaaaaaatc tttattaatt ttcaagtagt tacatcattc tctcctcact108840tcttagcatg aaggccattt atgtactggc aggtaaatgt caggttgaga aggctctaag108900
tcatttcaca gtagggaaag ttggtttttc aacttggaag caaattttat tttattattt108960ttagaaaatt atatatatat ataacttaaa atggaaaatt gcacaaatca taagtggaca109020gctccgtaca ttctcaccaa gagaacatat caatgtaatg aacacccaaa ttaagaaaca109080ctacatgggc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc109140gggtggatca tgaggtcagg agatcgagac catcctggct aacaaggtga aaccccgtct109200ctactaaaaa tacaaaaaat tagccgggcg cggtggcggg cgcatgtagt cccagctact109260cgggaggctg aggcaggaga atggcgtgaa cccgggaagc ggagcttgca gtgagccgag109320attgcgccac tgcagtccgc agtccggcct gggcgacaga gcgagactcc gtctcaaaaa109380aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aacactacat gattagctcc ccaatatcct109440ccattcggct actgtctagc caattcccta ccaagggcaa ctgctacact gacttctaac109500actgtaaagt agtcactggc agagattttg aaaggcagta tgtcctgctg aaatgtgagg109560gaaattccac tgatgatttt aaacctaaaa cgatatgaat atctttagca acaaaaccta109620ctttcctcca gaccacataa gaacccgccc atgcctatgt cctatttcct ctggagcatt109680tttaggttaa gttttagatc ttgtagtctg gtgatatagt acattttgac ataacatgga109740gtaaggatgc catgaggatg cccagctcat gtagggggtg cttggctggt ctgtgatagt109800cactgggaga aaggtttaag ggaagggctg gcatgtcatt tccttctccc tcttatcctg109860ctccataatg atcaccactg tttattcttt aaataagtga aaagggaaag aaataaatgt109920gtcatttaaa gggttccaat ttaagtctcc tgctttattc ttaagccctg cttaatcttt109980cttgattcta ccctaaggag tacaaatctc ttttggctga tccactttcc tttgaggaac110040caaaagtgaa cacgagcaaa cagattaaaa gatagcccaa gagcactggt caacatgtgc110100cctgtgtggt tggatcaagt agagggaaac catgatttgc tttaaaagaa taacggtcat110160tgcaatgtcc tgcttctgtt ctggggttca gaatgtgata ttctgcatcc agttaaagga110220
atctcttggc catttaccac agctaatagt aattaacaga acctactgaa aatgcagatg110280caccctcttc aaactagtaa gtgttactca tcatgctggg atattgagag agatttgact110340ttgagaagca tggagaaatg atttggttta aaactagaaa ctctggatta tacagatact110400catggcacta agcaaattca gaattaaaag aatgtgcctt cagagagaca aatgccacag110460gatctctcta tatgtgaaat ccagaaaagc caaactcata gaagtagaga ttagaatggt110520ggttaccaga aactgagggt ggtgatggtg gatggagaaa ggggagatgt tggttaatgg110580gtacaaagtt tcagttaggc agtaggcata agttctggtg atctcttcca tagcacagtg110640actgtagtta ataataatgt attgtatatt tcaaaattgc taaaagagaa gattttaaat110700gatcctacca caagaaatgg taaatatttg aggtgataga tatgctaatt agcctatcag110760atcattctgt gatatataca tgtattgaaa caaccttata cctcacaagt agatgcagtt110820attatgtcag ttaaaaataa aactaaaaaa aatttttaaa agaatgtgcc ttaaaaaata110880ttttgttctt ttcattaaat aataatctta gtaacactga cagtgagaat ctataaattt110940agcaatttcc aaagcaatca ttttaattgg atttaaaagg gatattatag tggataaaac111000cctcagaata ttttatgtag tagtgccatg gtttattaaa cagaattcat ttaaagtaca111060catgcaacac atcccgatag tttcttacaa accttgaaat aagcaattat tgagaagagt111120tgagagggtg attttctgag tttaacgaag aaggccttac atctagaagc ttgcagtctt111180cttgaagata gagattctga gttggttttg gctcagtgtc acccttgcct gaaatagtat111240gtggaaagcc acaataatgg gaatgagcat agtgtatctg ggggaggagt agacaggtca111300gtccagctga atgccgtgta tgtatgtttg tgtttgtgtg tttatacacc aagtgtaaaa111360taaaataaag tacaagtcat aaaattggac atgttacgga tagttttgta ttgtcataaa111420cacatttaca ctcaataaat gtggaacgaa taaatcaaag gacaaaaagc tttgaatacc111480taatggaacc tgagggtgtt catcctgaag gtaactagaa gatataagtt atttctctct111540
ttgtggccag aaaggctaga attcctttta tagacagagc aatgttacta gttttcagac111600agatgggaat tgaaacaact tttatcttta aagacaaaat cctacccaac attgtacata111660tttaaattta tgtgaagttg cccacaggca gtggaatgag ttaatcaaat gataaagaaa111720tgtcaaaaca tcttatactt gtatataaac ctggtagttc agtatcctat aaagtacaac111780caatccatct gtccgaaagc ctaataccac tatttttggt gacactaaat gctttaaatt111840ttgtcagcaa gatttgaggc aatgtcaaat gctagagtga tcaatatcaa atactagagt111900gataaaaccc caatattatt atatataatt atatgtgtgt atgtatataa atatatgcca111960aaatgctata caaatctata cacactttat ataagtacta tatgcacaca tacacacaca112020taattattaa ctaagtttaa aaaattccac gtgatgagat ttttttttaa ctttaaaaag112080tattagctca ttagacttca cttttttttt tttttttttt tttgagactg ggtcttgctg112140tgtcgcccag gctggagtgc agtggcgtga tctcggctca ctgtagtctc tgcctcctag112200gttcaagaaa ttctcctgcc tcagcctcct gagtagtgag gattacaggc taatttttgt112260atttttagta gacacagggt ttcaccatgt tggccaggct ggtctcgaac ccctgacctc112320aagtgatccg cccacttcgg cctcccaaag tgctgggatt acaggcatga gtcactgcat112380ctggccagct cattagactt cctgataaga tttcaaattt tatgtctttg tccgaagtca112440gatctataac tttaaaaata taaactagtt attttacttt gttttcattt gtttttcttt112500ctgatttttt aagtaattaa ttctaacaaa atggtctact tggctgtgct catgtgtata112560gctgatgtca gcatattaat agccagatgt agatgacata tcttgatctc tggtctcatc112620gctctactgt taccgtcaac attgttacca agcatgagct gggcaatgca aggcaattat112680tttctgaccc ttgcagtctg tataatttgg ttatccccta gatacaatct ctataaatag112740tgtttgttgg gttctggaaa ctagagtgga cagatggcat gggggacata atcaccaatc112800ttacccaagt atgtaacaga tctgagtata taaagaaagc ttgggtattt cttgtagtca112860
gcatgatatt ttgctcataa atttccaaca taatataaat tttgaaacaa aaaggtaagg112920aaaataaagc tttaggactg ttttcagcct gctatttttg aggaacaagt gacagagtct112980ggtcatcatt ccattctgta tctttggatt attttaatgg attatgtccc agatggatat113040tagcgtattg gtagggcatg ggcagctaag tggtcaaaat ttttaaaaag cagcagctac113100tggattggct tgaactgttt ccttaaaatg gcagattagt tttaccagtg gtgtttttaa113160tacagcttca catcaaagca gatttgtgta atttggccac ctgctataaa catcaatttt113220aatcaatcac atatatcttt gccaatatag tttatcagtg gtaaatgttt aaagattttg113280aaataaattt tatgataaaa ttaagcagcc atctggaatt gtaatatagg ttttttctaa113340atgatttgca agtcataaat tttaaacact atatatagag aatacacaca gtaagtgtac113400attcattttg tccctgttta caatattgtt tttgaggaca tttcattgtg aataatacag113460aaaatttacc ttctgaacag gacctatcaa cagtcttggg cagaaagaca tttgagctct113520gctggtctag acctgtgtgc ttagataatg agtccagcta ttcttgccag aactgcttgg113580tgattatgat tcaatctctg tagcttttca gtcagtgtga aattattgta aaaaacaaaa113640tctgctctct gatacattta tttcaagtgg tattgcttta ataatgtacc cccaatccaa113700gtataactta caagaaaaat gtatttagcc tgcatatgca agttagatat cctccccatt113760agagtagtaa cttcccaaac tgtttaggaa agatgcatcc aaagaatttg cataattatt113820atattgcaat ctggatttgt gaaatcaaag gtattggata tctaaattag taggaatatc113880tgcacacaac ccctcaatcc acttatttca ttacatggct tattttaggt tttcttttct113940taggcttatt tttgaataat tgatgtattc attaccagta gtaggggatg tgggggttgg114000tttttatctc ctctgtttta tccccctttt tatacttctt ttattgctca ttttaacatg114060ccacctgtgg gggtttctcc ttgacgtaac tagtattctt ctggctaagg ccatatttta114120ttagttttat ggcttgtctt tccttttatt caaaatctca ggtcttgaaa aagactggat114180
acgaatgtaa aatgtaagaa agaacaaaaa tacactttaa aaagactttg gattgccaat114240ataaagtcca ttattagcat tcataaaata aactacttta gagccaataa ggatgaaatg114300ctctactttt aatttctgtg gcactattaa aaatactgta tatgggatac atcctacttt114360atagggatta actttcaaca tgcaaataaa caagaatcgt ataaccagtc ttacgtattt114420aagatttaat ctaaaattaa aatattttat atatttgatg tgtatcctta ggttatcact114480ttatgtagat agatgtggaa gtccttaata cttaacaaaa cacatataat aggctgggta114540cgtacctata tcatctgata taaaactcct gtgaggtaac tagggctgac tctggataac114600aagctatcat caatatacca cagtacttct cacataagct atatttgtga cacagcttga114660tgtgtggtat aatattcata gttatgaata agcatatgtt tggataatac aggaggatgc114720aactcgctct tccttgaata gtaatgattt cacagagaaa ctaatattta tattgggaca114780cgaggaatgc ataggaattt atccagtcca atttaattat tgtacaacga aagttaaaaa114840gagaaaacgc cattgacttt ggaaagtagg aactccagct atgaaagttg gaggtgaaga114900gtattccaac aaaaagagta gtatgaaata atatagtcag ttaagggaaa gccaagaaat114960tgaagttcat aagattggga aggtaaacaa aatggtggag aagtagagta aggggcttcg115020aactcatcta aggtcaggtt atcaagggca ttattgccaa gataaggaat aattctgcag115080gcatagagag ctagccaata ttttaaagcg ataagactga catcagttta tgacttttat115140aaagagatta tcaacttata ttgtggagat tgtaccaaac aggaacagat tgatagcagg115200gccaattata caaaaatgat actgatctat tattttttta gcagaaaagg aagccatggg115260tttttctagg aagagctctc ttatatgtaa ctaattagca ttggttttac tgctagatta115320caataaaata tataaagatt agagaatatt gttcatactt aatttttttc attttttatt115380ttcaacaaga cagtttatca agatagttta tataatgatt tgaatacatc ttcatttttt115440tcatactttt taaaataatt tttttcacat gttcaagtta ctgttcatcc atgtggttga115500
cagaggccca tgaggttgat aaatgaactc cactgtaacc aaaacaactg tttttaaaaa115560taaatacatc tcctttacca agattttgaa gacatctgaa agcaaaagca attgatctgt115620tttaccttcc ttacctgaca cttcctgcaa agcaaacaca atgtaaattg ttagaaaaag115680attcaaaagg cagctgactg aaaagaaaag gtgaagaaag tacataaacg agcaacacac115740caaatgacaa tttaattctt gtacaatgaa agttgaaaag acaaaatatc attgactttg115800gaaagtagga actcttgcta tgaagattat tattactcat atataatgcc tttattattt115860attctgtctt atttatactg ttcaaaatct ctactgtgat agattatgaa acagagaata115920ttcttgtgcc tggaattgtt tgtccatgtc aagtattgtt tgatggtttt gacttgattt115980gacaagtcag gttaatcaaa acaatcaagg ctctatacca tatctagtct cattatactg116040tcaaaattta gatgttttgt aatagtaaag catattaatt gtttgctgca agaagttcag116100ggtccttagc tgtccttcta gcatggaaaa tgttgttcat tttagtgaat atgtaaagga116160atagttgggt taacttttgg gcaaagcaat ttattttctt acttaatgca agactagtac116220taatgattct tgtaacaatt gtcataaaga tgattcatat ttttctatgt ggctttataa116280atgcaccatc tatcataaga tagaagattc tagtttaatt gctaacattt atctttttgg116340gtctcatttt ccccctggag taacatttct agaaatgata aaaaaaatca ttacttaaaa116400gattgggctt taaaattgga attcaaggtt attagataca aatttctgtg ggggaggaaa116460gcacatgtat tatcctaagt tatatattat tttgtctgtt aagccattga tataattaag116520gggttaattg ttacaatcgt ctttggagat caaagtttag attgaatgag caattgaaac116580ttgctatgtt ttaaatgtaa gaaaagtagg aatttgcttt acagttatcc ttttaaataa116640gaccttacag gagagttctt ttctgtcatt ctccctctct tgccctctgc cttctccaat116700ctccattact tcccttttgc ctcttttccc tccacaaata tttattgaga gattactgaa116760tgagtacaaa atgtattaat gtagtgacaa atatattgct gtacaaacaa atgcaaaact116820
ttcttagact aaaatactgt taaggttagt tttgagcaat atttgaagaa ggaaagggct116880gcagtgttgg agggaagata tcaagagtgg acagtaacta catcaggata aaactgacca116940tttaggagca agtccaaaag cccaattagg taaaaggagt cttagaggca tggtagcact117000ggcaggcaag aagtcatgtt caagctagca gagggggaag ttctattaga tgatgactca117060agtaaggaaa taataaacta cagttctagc aggctttcat gagggaaaat tgcatggtac117120agaaaggggc attggcaatg agaagggagg cacaagcagt gttgggctat caaagaggat117180agattcattt taagagaaac caggtcactt tggcttcaac agtaaacatt ggttggtcca117240tagagtggat aaacaaacag agtgaacctt tgtcaaaaat attaatttaa attgtttggt117300tacctgctac tgttgttgtt gttttgaggg gagattatgg ctatcatgca atcaaaatag117360tacctaaggg ggacaatttc agagagcata gtgattaaga gcatgtactt tggagtcgga117420ctgcctgaat tcaaatccta gtttcactat ttacaaactt tgtgactttg ggcaaattat117480ttaacctctt tgtacctcag tgttcttata tttaaaatgg ggagaatagt agcacatacc117540tcaaaagatt gccataaaca ttaattgaaa tatttgtaaa gtgcttagaa taatacctga117600ccaatagtaa atggttgtta agtgtatatg tatatgagtg tgtatatata tatgtgtgtg117660tgtgtgtgtg tgtttgtgta ataaaggctg tatgcttgag tagctcatga cagaaatggt117720aaacactacc atttaaggga gcaaaagaca aatgtatggt aatgtttgaa cttgaagtaa117780agcttgcagt atgtaaagga tggagtggat ctagagttta tttattctgg ttttaccagg117840ccaatctagc atgttcttgc ccaaacatgc taaattagcc tagatgtact gttagttcag117900ccaggtaagt attaaaaggt ctaaagtttc aaactcctgc tttagggaac aaggactatt117960gagattccaa actactctag agttagcaaa attggaccaa gcttctcttt ctaggagtct118020tgagaatatt cagggctaga aaccttggtg cttctgagaa caccatacca catagtctac118080ataaatccag actccaaaca aacatgtcaa atacaagacc ggaaaggatt ttagagctgg118140
ttcagaggct gttacctgta ttttgctcat tcatgaattg ctggcccttg tgattttttg118200tgggtggcac ctgggacttt ttgacatttg aaagtctctt tcaatatttg catctatgat118260gcatccattt ggaaagtcct aaaaatatga agatattttg tagaaatttt aggatgatgc118320agattaagaa acggttaatt tatggaacca aaaaagagcc cacattgcca agtcaatcct118380aagccaaaag aacaaagctg gaggcatcat gctacctgac ttcaaactat atacaaggct118440acagtaacca aaacagcatg gtactggtac caaaacagag atatagacca atggaacaga118500acagagccct aagaaataat gccgcatatc tacagctatc tgatctttga caaacctgac118560aaaaccaaga aacagagaaa ggattcccta tttaacaaat ggtgttggga aaactggcta118620gccatatgga gaaagctgaa actgcatccc ttccttacac cttatacaaa aattaattcg118680agatggatta aagacttaaa tgttagacct aaaaccataa aaaccctaga agaaaaccta118740gacaatacca ttcaggacat aggcatgggc aaggacttca tgtctaaaac accaaaagca118800atggcaacaa aagccaaaat tgaccaatgg gatctaatta aactaaagag cttctgcaca118860gcagaagaaa ctaccatcag agtgagcagg caacatacag aatgggagaa aatttttgca118920atctacttat ctgacaaagg gctaatatcc agaatctaca atgaattcaa acaaatttac118980aagaaaaaaa caaccccatc aacaagtggg cgaaagatat gaacagacac ttctcaaaag119040aagacattta tgcagccaac agacacatga aaaaatgccc atcatcactg gccatcagag119100aaatgcaaat caaaaccaca atgagatacc atctcacacc atttagaatg gcaatcatta119160aaaagtcagg aaacaacagg tgctggagag gatgtggaga aataggaaca cttttacact119220gttggtggga ctgtaaacta gttcaaccat tgtggaagtc agtgtggcga ttcctcaggg119280atctagaagt agaaatacca tttgacccag ccatcccatt actgggtata tacccaaagg119340attataaaac atgctgcaat aaagacacat gcgcacgtat gtttattgcg gcactattca119400caatagcaaa gacttggaac caacccaaat gtccaacagt gatagaccag attaagaaaa119460
tgtggcacat atacaccatg gaatactatg cagccataaa aaaggatgag ttcatgtcct119520ttgtagggac atggatgaag ctggaaacca tcattctcag caaactatcg caaggacaaa119580aaaccaaaca ccgcatgttc tcactcatag gtgggaattg aacaatgaga acacatggac119640acaggaaggg gaacatcaca caccggggac tgtcgtgggg tggggagagg ggggagggat119700agcattagga gatatatcta atgttaaatg atgagttaat gggtgcagca cacccacgtg119760gcacatgtat acatatgtaa caaacctgca cgttgtacac atgtacccta aaacttaaag119820tataaaaaaa aaaagtagga atcaggcaaa aaaaaaaaaa ggttaattgt cctgttgaga119880ggttgattca gattttctgt tattctaggg ggagagttct attgatgaca aaaatgtaaa119940tttctttcta tgtcattttg ttcagtctgg ggagtagcaa aggattattc tttacagtat120000gttttctaat gatttgtcca aactgatttt gtattccaga atcacatact gctcttgggt120060ttttctcccc acatttccct tcagtggatt atttatactt ttaacaaaat gatgaatggg120120tcgttgtata ttcaaaatgt gttcacttcc cctggagaat ctgagtgaaa caagtacatt120180cttgcagaag aatcctaata tggttaccta gtcctttgaa attggtttta tctttgattc120240tgagaattct ctacaaattc aatgctgtat attaaaaagt tacaatattt catattttta120300atagcagaga taaaattgta gaaacaagtt ataatagaga aaagatttta gtttcttctg120360gagagcagta tttcataaca taaaataaat ccacttaggg atttatagaa tattttctct120420acatattact atgaaacttt taagacataa tttttttttc tctttcctgg aaatcctttc120480tctctcttcc tctctgttgc ccttatctat cccccacccc attattgtac tttagcactt120540aagcatttaa ctacagtttt gaccaacaga tgtatctgtt tgtttccata tagtaatata120600tgtttatttt agagaagaaa aaataagaca aagtaaaaat atacagcaac tgaggcacaa120660aattctgcag tgacttgctt catttttccc ttcctattta atcaaagtac tatcaaaaat120720tctatttaaa tttctcaaat tagaatatag gaaatatcat tcagatattt taaaaaatgt120780
aattatatac ataagcataa gtaatagtac agaatgttgc atgagatgaa aatgtatata120840agcttagctg tcattgatca tactgaaaat tatttctaag atggacttta ataggctaca120900gatttttaag atttttaaaa ttgtaagctc tgatcaaggc actgtgttac ttacaggggg120960atgtatgcat gtgcatgact tggtccatac tttccagaaa tttataattt agttgaagag121020aaaagaagta gacaccatga cgatacaatc tagtttgtga gtggcacaga ttttgctata121080gctcagaaga ataaaggcat ttttaaattt caatagtttt tggggaacaa gtggtgcttt121140atcacataga taagttcttt agtggtgatt tctgagattt tggtgcaccc atcacctgag121200cagtgtacac tgtacccaat gtgtaatctt ttctccctca cccccctggc actcttcccc121260ctgagtcctc aaagtccatg gtggtattct tgtgatgcct atctcccact tataagtgag121320aacataagat gtttggtttt ccattcctga gttacttcac ttagaataat gatttccaac121380tccatccagg ctgctgcaaa tgccattatt ttgttccttt ttatggccga gtagtattcc121440atgatacaca aacacacaca cacacacaca cacacacaca ccacacacac acacacacac121500acaccacatt tcccttatcc acttgttgat tgatgggcat ttgggctggt tccatatttt121560tggaattaca aattgtgcta ctctaaacat gcatgtgcaa gtatcttttt catataatgg121620cttcttttcc tcttgggatt cctggatcaa atggtagact tacttttagt tccttaagga121680atcttcatac tgttttccat agtggctgta ctagtttaca tttgaccagc agtgtaaaag121740tggtcccttt tcaccacatc caagccaaca tctatttttt taattttttt aaattatggc121800caatttttgc atgagtaagt tggtatctca ttgtgatttg aatttgcatt tccctgatca121860ttagtgatgt tgaccatgac ctattttggg ttcaagtttg gctttgggaa gtgctttgga121920gcttcttctg agtccagcca ctgagctggt catcaacagt tgtataaaat ccacttttca121980ttgcatgtca caattcgatc tagaaatggt ttgtcgtttt tgtgttgaat aagagaatat122040gacacttcca aatgacattt ttttaaattt tcagtcagct catgaggcac tcacttactg122100
agctttttca cctttccaat ttgcttcaaa tgccaaacga ccatagaatg gtcaatgttg122160agttcttctg caacttcttg tgtagttgta ggaggattag cttcaatgat ggctctcaat122220tagtcattgt caacttctga tggctggcca ctatgcttca catcttcaac actctcacct122280cctttgcaaa acttcttgaa ccaccactgc actgtatgtt cattagcagt tcctgggtca122340aatgcattgt tgatgttgtg agttatctcc actgctttat gacccatttt gaactcaaat122400aagaaaatcg cccgaatttg tgttttgtct aacatcattt ccatagtcta agataaatct122460aaaataaaca gcaagtaagt cattagcaaa acaacataaa gcaagaaatg cacattaaaa122520tgatgtataa cataacaaca cttatttaag actgtatttc aatatcaaac agcaaatttc122580aacaatgcaa aaaccgcagt tatgtttgca ccaacctaat aactgtgaaa tatactttgc122640tttaggctgt ttctgtcaat gaagctgact agttacaatc ttactaggtg ctgagaattg122700aaaggaaggt gctacagttg acacagatca ccagtcctac actattcaaa attttaaatt122760aaaaaatatt tattgagtag tttttatgtt caagggactg taaaagacaa tggaaataat122820tttctagaag agtaaaaaac agttttgtct ccaaaaattt caccatccac attcggaaac122880aatcaagcta aaaagtcaaa ccaaacaaat caagctttaa tgaaacatgg ttggaggaac122940tcagaaaaaa gggtgtctaa ttctgttttg gggtatctgg taagctatga ccagaggagt123000aaatctcagg ataagtccca aagatagacc aggtaggaaa gggcatttca ggcagaggaa123060actttatagg cagatacact gaagtgacgt gaagtagaga atcctaagga aattgcagac123120taaatagtag agtgctgatg gagttgtcaa agccatgacc ccggagtgtg gcaaagggca123180gctcgtgaaa tgtcttgcac attagcccga agtaaagtgt tttgaagtgc agtccttcga123240gtcctgtaat gttagaagaa ataatgctgt cataatccct aaacatatta tgacaagaca123300taacacaaat ctatgaagtg ttgtgaaaca ggatggtgca gtctaatgtg aaacaagtgg123360tcatttttca ggatgaatct agattccctg gggtgaagga gagtcagagc gtaaatagat123420
acggaaagtt taatgagctt tgaaaggcaa tctttatcga gtcagaatgt aaaagagtca123480caaaatgaat aacacaaatg tattaattta tctaataaat attaactgcc tttaatgtat123540ccctgtggga gatgagagtc ttgttcttga gaatttcata acataccaca aacatcaaga123600tctttgagtc tgaagaacca aagtaataga attggctgga cgatgttgtg gctacttctg123660gccccccagg tgtcttgagt taataatatt gctgatctgg aaatagtagg aaggttaatg123720aacaattgca tttcttaatg ttcttgtacg tgtttctttt gtgaactgaa tgttagccta123780tttataagac atgccacaaa gtgatctagt aggaactttt taagctcatg ctacaaactt123840ggggttgtga aaactaaagc aaataagttg gtatttttag tatgtaatga aaggaggaaa123900gttgtggatg agtagaacaa agagataggt ttaacaatca taacacacaa agtcatttgg123960tggcctatat ccaaactttc attgattttg ttcatgtttt gtcctagaac cttgagaatc124020aggagaatct agtctcttcc ccaacctcag gggtgaagct tgattagtcc aggccagtta124080tggtaattcc ataccattgt caagtgactc attctgttat ggacacagga cgacagaatt124140ttggcaaata agatatgagg gaaaatcagt tgggtagctt ctgagactgt tttagtcatt124200cttatttagg atagaaagat gagaaaatgc ccttttgtgg cttttcagta gtactgcgtg124260aggatgtaat atttgaagct gttgcagcca tcttgctatc atgaagggcc agaggatata124320gttctacttt ctgatgttgg cagtatggaa gggatggaaa gaacaggagt tatttttttt124380ataatggact gaggaattaa ccagctaacc attcttgccc tgccatagct ctaaactctt124440acataacata gaaaatgtat ttacaaaatc caatcttgtt ttaattgttt ttcttttcct124500tgcagctgaa agcattcttg gggaggaacg catttcttct atcctcttat tttcagtatc124560tggaagcctg caaattaaac aaaccacaaa aaaaaaggca gatctatagg aggaagggca124620tatatttctt ttcttcttaa aattttattg gagtatgatt gacaaaaaat atgtacatat124680ttaatgtaca caactttatg atttcaaaga taagtataca tccatgaagc cagcaccaca124740
gtctatgcca taaacctatt cattacctac aagagtttac tcctgacttc ttatctatta124800ttcttatttc atatgataca aaaaagagaa aataatttaa aaatattgcc acaaagaagc124860atcaaaacac aaagatagac aacatgagat ggagagagga acacaataac tgcaaaacat124920tcagaaaaac agttaacaaa atggcaatag taagtccttg cctatcaata attactttaa124980atgcaagtgg attaaactca ccaataaaaa gacacagagt ggcagaatgt gttaaaaaat125040aaaaccagaa tgcaactata tgcagtctcc tttctctttt ctgtatctgc tgcaagtttt125100ttctttgtgg ttacaatgag gcttgcataa aactctttat tactgtaaca gtccattttg125160actaatgaca acttcaattg catgcaaaaa ctatacttgc actcccctgc cccactttat125220taatgtcaga attaacttat ttttgtacta tgtattcatt atccaacttt ctgcagttat125280agtttctttc tatgttttgc cttttaagct ctatgctagg gttaagagtg atttacgcac125340cctcattact attttacgtt attatgtatt tgtgtatata tttaccttta ccattgagag125400ttatgctttc atatattttc atattactgt ttggtgttct ttaatttcaa tttgaagaac125460tccttttagc acttcttgca tggcagttct aatggtaata aacttcttag ttttggtttc125520tctgggaaag cctttgtatc ttcttcatta ttagaggaaa gattttccag gtatattatt125580attggttagc agtttctttc tttcagcact ttgaatatat tatcctattc tctcctagcc125640tggaaagttt ctgctgaaaa attcattaat agtttcatag ggatccttcc tatgtgatga125700gtcacatttt tcttacagct tttaaaattc tctctttgac ttttagcaat ttagtgataa125760tgtgtcttag tgtagacctc tagtctttaa gttccacctg gggttttggg ggcttcataa125820atctggatgt tcattttcct tttcagattt gggaaatttt cacccattat ttctttaaat125880aaggattttg cccctttctc ttttattttt tttcctgagg tacccataag gtaaatattg125940atttgcagga tgttgttctg taagtcctgt aggctttctt cactcttttt cattttttat126000cttttcattc ctctgaagag ataattttaa attacctgta tttgagctaa taaattcatt126060
tttctgcatg atattctgct gttgaaactc tctatagaaa ttttgaattc agttattttc126120tttggtggta gaatttctgt ttggttctct tttatgattt ctatctcttc gaggaacttc126180ttgttttgct cctgtatcat tttcctgatt tatttatttg tctatctgtg ttcgcttgta126240acttattgag tttaagatga ttattttgaa ttcttatcag gcagttcata gatctccatt126300tcttcatggc tggttactgc cattttattt tgttcctttg ttgatgtcat gtttccctga126360ttctttgtga attttaggac ttgtatttat gtccatgcat ttgaagacat cattttttcc126420agtctttaca gactaatcag tccagtcaga gattctgggt gagctggttg gtccgctggg126480ggcaggactg ctgttgatgt ctttgggaag gtagcctgta acctgggttt ctgggagcag126540gcctggttct ggtttccact gtggtaggtc tggttttggg gtcatgataa agtctaatat126600acacttttct ctccctttct tccacaggtg aactcctgag ccaataagat ctctttgggc126660agttcattaa gtgggctagg gaaatactaa tgtggaagtg aaaccatcct ttctactctg126720catattgtgc cttttctaat ttatgtgctc tatttatgtg ctgcagtctt tcacctggat126780tccagagttc ttatcaagat gttttgtcca tggatgtttg ttaaattaat ttctgtggga126840tgacaagggc tggaaccatc tattccacca tattgctggt gtcatttccc catatgttgc126900tttatttaca ttaatatttt atatgcttga ggtatcagaa aaagaagtgg aaaccccaaa126960aggcagttag accccgaggc atatgtacca ctttaatgaa gggcaataaa ttgcagagaa127020gaaatcagca aaaaaaaggg atttgggctc ctaggggcag taaattgtga aaatgtgact127080agtattgtag ataaaggctg tttagtatgg tttgtcatac agataagagt tgtttacctc127140ttccaggtac aggagaggag aacaccttta aaaatggaga cctatgtcac ttttacaaag127200gaaaatttat gctgtgattt taggcagaaa gttgacacca gagaattctt cctgctgctt127260ctcaatttcc ttcagctcaa aaatgatcct tatgccaata tggaatattt ttggggtggc127320atattctgct cctcttcagc atccttcctg gtatgtgaat tacccaactc ttgtgttctc127380
agaagttggg cttgagcctt ttgttcaggc ttatgggtac attttgtact ctctaggagc127440taaagcagat gggaaggtag tttttagcta agatattttt acaaatcata atttttatgt127500ctatagtaaa accaaatttt aagcatcatt acagcaaatc tgaagtggat aaatgaactg127560ataaattttt aaaaaaatta agatagtatt aagaaattga catgtagatt ctaaactaag127620atttaatagc taacaatgaa gacatcttcc ttatttttat gactgctgag agcaaaaaca127680caaagaccta aagcaagtaa ttgaaataaa aaatgatgga ttgggctggc agctattctt127740tagatataaa actaaatgca gtctgtctgg aatttaaagg gagtgggtga tccttagccc127800ttccttcaga tagacatgca agaaatacaa agtttaaccc ttaataaata aagcctggga127860gtaaggaaat tcagaaattt gaatcatatg accaataaaa tgtctctttt tatatcacta127920ttgatatcat ttgtgtaagg gtttgaatgg catttaagaa cctcttggtt atatgaaatt127980gaatttcagt gaaactaggc tgttattttg tgaagtatct gacttagcat tttttaagga128040agatatcatt ttaattagtg tatttgaagg tcgagtggat acttttactc tttttaagta128100gtggttttct tcacaaactt cggttctgtg tcatatatta ctgatcttta caatgtctct128160gagttactgc tgttttccat tcttaaattg ggagaacttt attcctgatt gagaagcaag128220aactgaaaat gtcacttttc cctttgaggt gtggaggaaa tcttttggaa atgttcagtc128280tctagtttcg taatgtgtaa cttatacttg tatagaacgt taggtcaaaa tttttttacc128340agtggcattt ctcacattca ggtgtaaggg ctcgatgctt gcgtagatac aggaaatcaa128400actcacaaaa agtctccact tgttttaggg aattcagtac ccagctgaga gcaattacag128460gcaatattaa tatgttggca agaaatgtca gagttcaaat ggccagtctg agtgttcact128520ttttccttta tttgctctgt gatcatggct ttagaaggtt ttcttgttaa gaatagttgt128580gacctcacct gaattgaaag gtggaagtaa tgtttcttat catgtgtggc atggcctctg128640gtcaagtgaa aattattcac tcacttggaa aatgtctttg gtacaggaaa tgatatcctg128700
aaattcatta agggtttacc attgggttgg attctctata tgaagtgatc acagaacttc128760aaacatcatt ctatgaataa cagcttccta gggtgcatgg agaaaaactt cattttctca128820aatatttatt gggtaccaac acaggagacg ggcctgtact aggttattga tgtctataga128880tagttaagga aacttaagaa gtttccttaa ctatctatag tttccttaac tgtacctcaa128940ctatatcact tgcagctcat tatgtgtagg tatctctgca tgtatgatct atttccttct129000actgctacag actagtagat atcacagttg gcaattctac caaaagaacc tatagtccca129060gctactcagg aggctgaggg aggagaatca cttgaacccg ggacacagat gttgcagtga129120gccaagatcg cactactgca ctccagcttg gcaacagagc aagattcagt ctcaaaaaag129180agagaaaaaa aatgctcctt ttggtttccg atctgtttcc ttagggagaa attgttcccc129240tcaagctctc tttctaagag agtggacaga aatgtcttat ctctccagtc ggtaattatg129300acttctctgt aagtctacta ctacagacta gtagaaggaa atagatgata catgcagaga129360tacctacatg taatgagctg caggtgatat agttgaggta cagttagatg cagataatac129420agttgaggta gttatagctg aggtgcaagg gacaaaaatt agacactgtg tgattaaaag129480aaaatcatcc atcatctgag caacaactat tcattgaaca cctctaatgt gccaggatca129540cgctttgtac aagagttatg atggtgaaca aaatagactt tcagagttta ttcttgaatg129600gtaatgtatt aattaaaagg tctcattaat gtttaattac aaactagatt aagtattgtg129660gttcaagtgg acagctgggt caggggtgga gtatatctag gatagagaat ttcagttcta129720tattttacta attaactggt aaccaggagg tatgttctat acttacattt agctctgtgg129780cctgttgtgc ttcaatttcg tcatcttcaa aaccaggaag agctatattc atcttatctc129840acaaagctga ttaacataaa tgaaggagcc ttggaaaatg gaaagcatta tacaaatgta129900agttgtatag agttccacgg taattgctaa aaatactgag gcaaagataa tcctttgtag129960acagaggttt tggttaactt gtgagaatag agttagtaga atgctagaca tagaaaacag130020
atttcagtga tttcaggaga aaatcagagg gaaggaagaa acatgaggtg ggtccagaag130080tggaagtctt caattccttt agaaaaggca catgtagctg gaagcagtgg ctcacgcctg130140taatcccagc actttgggag gccgaggcgg gtggatcaca aagtcaagag atcgagatca130200tcctggccaa catggtgaaa ccccgtctct actaaaaata caagaattag ccaggcgtag130260tggtgggcgc ctgtagtccc agctactcgg gaggctgagg caggagaatc acttgaaccc130320aggaggcgga tgttgcagtg agccgagttt gcactactgc actccagcct gtcaacagag130380caagactccg tctcaaagaa aaaaaaaaaa aaaacagtcc ccggtgtgaa catggcacgt130440gtatacatat gtaacaagcc tgcacattgt gcacatgtac cctaaaactt aaagtataat130500aataataaaa taaaaaaaag aaaaagagaa aaaaaaaagc tccttttggg ttccgatctg130560tttcctcggg gagaaattat tctcctcaac ctctctttct aagagagtgg acagaaatgt130620cttatctctc cagtgggtaa ttataacttc tctgtaagct ataaataggc aaaaaaattc130680cctaaggatg tatgcctggg gtgttgtagg ttttagtcat acctgaaagg gttgctcctt130740cttccttttt cagagtactc tgtatcgtta tctattcctt tcattttttt tctgaatatt130800ttcctaactt attttgtcca catgttctac aggtaaacct taaagattaa attctgttga130860ccctgtgctt tcttcagtct aactccttgg cacactgaaa ccacatttga tattgaatgt130920tttaacataa tctatttcag gaagtaaaaa aaatcctaga gctctctctt attttccttt130980atgttaaata atcaccctct ctgacattgt agctttttaa ggaacacatc atgtagaatt131040gataggttct tttggtagaa ttcccaactg tgatatttat ttcatgacta cacatcattc131100tcagcaggtc aaaaatcatt gtattatgaa catctaaatt ggttctttaa tatatttttg131160ttagcagcag cacatctcct gaaaagcaac actgaagtcg attctgcgga cataaggatg131220atttggcatt gacatctgtc agcctgttaa ttactaagga agatttggct gaattaattt131280gtttcctggt tagctccttt tctctgctcc attatgccct ttactatgtt gcaaacttga131340
acaaattaaa gatacattcc aagatatgag aagaattttc atcaaatgta tgaaaatcaa131400gtacatgaga aattcagttt ccaaaatata gggcatcatt gtgcagacga acagcttttt131460gaacctttct gttgaggaac acttccagtt ctataacatt tcttcagaca tttaatgaca131520gtttcctctg tgccaggcac tctctgtaag gtgaaagctc aggctgggaa gaggggtggg131580agtagggtga atgggaagcg ggtggggaca aggaaattaa cataagtgga catgcacaac131640aaaaaggccc tttcgggcgt taattttgta tcacctgcct gtatttctat tcaaacatga131700aaaatttttg aaacaaattt gaagggggag tggtccttca ccaataaggc accaataagg131760caggttattt tctcctttgt actggcaacc atcttttctg tagtttatgc tctgctcaca131820ccctatgtgc ttgtttccca tctgagataa ccctgcccct tttctgtttt catgaccatt131880attcaatgga aaattggaat aaagtaaaac aggacaagcc tgaattactt tgggctcttt131940gttatatctc atcatttttt ttggtctctt ttctccacta catttaaaac aaaaaataac132000ctttgcctgt gcttttccct cacttctaaa tatgtttttt ttaacctttt ctttcttctc132060ttttgtgctt gctttcttag ttaacattac aaattttctg ttttttctaa agctaatttt132120aaaaggaggc ctataatatt tgtgtaaagt ttttcattcc tccagtcatc ccattttcta132180tatgacttta atgtgttatc tgccagaaca actagaatag atatctccat tatttctgca132240cagatggcag agtgaacaag actttgtcct tagaatttcc atcaacaaaa caaaaccaaa132300ccacttacta tatatgtatt gccattcatg tttaagtgct gaaaatggac ttggagactt132360atctcagcac tatcacttat gtactctaac tcttctttat ttgagtaggg aatccttctt132420gtgacttcct tcagggtgtg gacacattga aagattaatt attcacatat cagctggaaa132480aaagtgaggt gacaagtgtt gacatttgcg tttctgaaag aggcacattg ttacatcaaa132540aaaaggataa tgccaattag gatttcatat gtgttgtttt attttcacaa ttacaatgtt132600agaggaaagc tcaaaagtaa aggcttttgt gaaaatgatc agatgataaa tcttgatacc132660
tgtgtaagaa gtgaaagcac cagagttttt ttagaagatg aaaaatgaaa aaaaaaaaaa132720aaagaaaaag aaacaatttg gcattgttag aaattcttta ttgggagtgg aaaaacatga132780aataaaggga aaatagcttt aatcaactcc aaattccttc tttggaagtg ctgtgtgtaa132840tctccaataa tggtggtgta catttccccc aactctatta aaaccatcat tatcattgtc132900atcttcatca acatggtcat catcattgaa cacacactcc atacaaagta agatgttatg132960tgtttgtatt ataagcagag attagacaat aactctaatc acaaggatgc tgtaactagt133020agtgtagatg gtagatgtgc acaacaatga agggatgttt gatggtatct aagttgtgta133080atcattaggc ttacttgaag agtttcccct aatttttcta tttttctttt tccttttttt133140tttttttttc aaacagggtc ttagtctgta cccaagctgg agtgcagtgg cacattcctc133200atggctcact ggaggtgcct cagcctcctg ggctcaagca atcccccaac ctcagcctcc133260ctagtagcta ggactatagg catgccccac accagctcat tatttatttt tttatttttt133320tgcagaaaca tagtctcact ctttttccca ggctggtctc aaactccagg gctcaagcag133380tcctctgtcc tcaacctccc aaagtgctgg gactacaggt atgagccact gtgcctgacc133440agaatttttc ttgaatgtga tattctcctt cattctatta cacataattt ctctaatctt133500cataatttaa ttatcattga atttcagtct atctgattca tgtaaagaca acctgtcatt133560ccaaacatga tttgtcctct ttacaaaact aatctgatat gaactgtatt tgattcacta133620gagaacagag tatagtgatg cctcaagtta ttgatacctg cattgatcag ggtaactaag133680gcttactact ggaacaagca gtgctgtaaa tctcatgggc ttaacatgaa gtctgatatg133740gatttgggtg ggggctttac tagggggctt acctctaagc agtgacaaaa ctatgtaggc133800tttattcaat tgtgtggctc tgtcatcttt aagtccatca cttcctgcct cagctacaga133860agagagaaag aatgaactac caaatgagac tttttaggac tatatcacat gtggcttcaa133920cttaagagca acggtagctg ggaaatatca tcttcctgtg tacctcccaa aaaataaaat133980
gggtttgtga atacatagca ttttctttat tacactatag aatatccaaa tagagatcgg134040atattttata gtgtaataaa gaaattggga aattaggagt tagggctgaa tgataaatat134100agcctttgaa gacagtgaca atgatataca gttgattagt tggatattgg ataataaaac134160ccatcaccta aagaaagagc atagcaaatg attaaaaaca ggatttaaag aatggttttt134220acaatgaggg acaatggtag aagcttattg tggtgtggac ttgtaattac ctcttaattt134280ccattttttt cttcctttgt aacaaaactc tagttttttg cctaactaaa agactgttgt134340gtacccttct ttatagtagg gtataaccac atgactaatg tcacatataa aaatggagaa134400cgggtgcaca ttaaagagta ggtaagtggt taatatactt tttctctctc aatcctccca134460acctgccctc tttaccttta tctctccaaa ataacatgtt tgttgtttaa tagagatgac134520atcgtcctaa tctaaggctt aagattcctg taactcttaa gtcacacttt gccaaatttt134580tattcaatca ctgaaggctc acattgcctc tgaaagaaaa aaaaaaagca agtgaaatat134640ttctgactgt gagtgttctt atattggcat cttagtgtga acttagggga tatgttagcg134700ttgactgttt tctgtatcac ctcaggtgta ttttgtcttt cccctcttga cttcacttac134760ccactcactc tgactaatgt cctagcagtg gcaagcatgt agatgtctaa aaatgtagaa134820attgtaagaa agaggctgtt tcagggcagc atttggaagt ggctattgtg tagggctaac134880catatctctc tcctgccaga ggtcatggcc ttgttgatgg tctctagtca agagcaatcc134940cattagtgaa aaaaaaaaaa aaaaagaaaa ccagcactga cagtgactgc ttccaaatat135000tctcctgtct gctactatag aatttcctag tgtttcccat cttgtcaatt cctttccctc135060acctttttta cactgagtga acaactttta tttgaagtgt taggtactaa cccagttctc135120tcacccttta ctctgcttcc ttcctttctt aaatgcttcc tgctttgtaa ccctctgcag135180ctagtgatac attagtttat gtttgtgttt tctcaagaag tgaaactgtt gtaggttgac135240ctattatata gaagtacata ctcctcagta gaaggcaact tatgattgta gaaactgggt135300
gtttcgtgag aagttgctac ttaactgacc aattaggaaa aggggtacag aaatgattga135360gacctccaag gagatacaga ttcatttaag ttgagtgtac tgctgcagac atcattttga135420atatctgtat tacgagtaaa tggtggaaat ttgaagacaa gtccatactt tatgaaagta135480agagaacaag aaatttgttt ccctaaatct gtgagcatac cctataattc atcagaaaca135540gcaaattcac aaacacaaaa ttgacagaaa tatgtaaaac ttttccagca gtttacttct135600gaatacatta gaaaatgtga cagaacatag taaatttctt gtcattttac ttcccaaggg135660aagtgctagg tttgtaaatc ctagaatatc atcaaattat attttgaaat ttatttcttt135720ttgagctaga attttaaaag attacatgtt ttttcacaga atacgttcat ccagttacta135780ataatgatgc tgaaggaatg gaaatgtaat ttctagaaat catcactttt caaagtttta135840tagtttgtga actggaatac tgaagatgga agtatgattt aatatttggt agaaacagga135900gagtttgtta tttgtagctc tgatattaga aattacttga ggtttctgtt accaaacttc135960acaaaatata tttcataaaa agcattctta actcaggtta tacatttttt aaaaattatt136020ctgaaaggaa ttagatattt aacattgtag ctgacctaaa taaattggag aaaattctta136080aacaattatc tttcattttc ccatcaataa atggagcaat aataatacct aattatttat136140tgcacaggag tcttgcaata attaattaaa gctttaaagt actttgaaga tgaaaacaat136200tttataggcc tcattattaa aggtaatttg ttatggtaac cagtcaaagt cattcatttg136260gtcttttaaa cttgttttta aatgctctat tcggatccag gtgttaatta aaaaatttta136320aaacaacact taggaaacat atgaaattct gctttctatc ttgatgctta acttgtgaaa136380taataggtaa gttttttttc cgaattttgt ttttttcatg tttatacgcc tctctcaaat136440cccattgagt gagcgagtat tgctcccagc tcattattac aaaaagaggt ttgccatgtt136500aaagccacta agatttttct ttttctgaag ctctttactt aatgcaaaga caaagtgtca136560tctatgataa caattctgca tatggaaaac acaaggttat tcatccattt aaacatttat136620
tgagcaaatg ctatagttta aaaaagataa gccactcggt aaattggaaa atatagtaat136680atgtcacttg catgaaattt ttatccaatg aaataatcaa gtaattaaat ttaaggtgaa136740agtgattgat gtaatatagg ttaaaagcca gtatggcaaa ggctgaaaca ttacaaagag136800aggcatcaaa tgtggttttg ggaagcactc aatttttgtg tagataatat cctagatgta136860cctgtatttc ataggaaaga aggcagtagt ggtattctag aacagtggtt ctcaacaagg136920gcaatagtcc cctgtccccc attcctggga catttatcaa tttctggaaa tatttttggt136980tgtcacaact agggaagtgc tacttgcatc tagtgggaag ctactaaaca tcctacaaaa137040cacaggacgg cccaccacaa cagagaatta tccagcccta aatatcaaca aaactgagct137100tgaggaagtc tgctcttgtt ggaaaacaca gaactatcaa ggcaccagat ggagaaagta137160taagatgtat atcaggaata gcttggcagg agtagacgtt gaaggtaaca ttgaaaatgc137220tttaggatag ccttgattat tagattagac tacaaagctg actcattgaa tcactcacgc137280actgtgagtc attcaataaa catttatatc tcaggcaata cggacagaga gatagaagat137340atagatgctg ctgtaaagtt tacaatttag ttggagacag tcagataaac cacccactgt137400gtgaacaaag tgatatctgt caaacaccaa ttctactgtg tctttaaaaa aagttcaatt137460aaaaataaat tttggaaaga gtatgcacta catacttctc cacaacttgg gactatatac137520aatcttgttt tgtgtatcag tttgccttta tttcagccag catttctttt ggcagtgtac137580ttttaattcc cttttatata acaactatta gcaacccatg acgtattgga tagcttccct137640tccagactca ctctggaccc ttctctgtgc tattccaggc tcaagatact gatcttcggg137700aacttcatgc tgagtgtccc tgtgttcggt tcttgattgt gtttggccca agagggacat137760ttataggaga tgagagggtg agaggagaca ggggttgggg catttggtcc ctcaactccc137820tcctccaaat agccaggtca ccacagactt gctgcatccc tccactgaag gccacactcc137880tttcagatgc cctttcttat agagctaccc tgtctgggtc cttataactg tttcctctcc137940
ttatcccttc tatctaaagc tggcaatgtt cctcatctgt tgtgagctgt atgctgcttc138000actatccctc tttaggaaac tgcctacaca tttgtaaaaa tcctttatta agcactcctc138060aaagtgccag tctaggattc tcattgttat atatggggaa catgacttgg gaactgcttg138120tatggtagtt gcttttaaaa agagttctgc ataggaagga gtccgaaaag tttaaatttc138180atattatgac ttatgcacat ctattgaaga atgtatctgt tagcttattt attcctgcat138240gtatgtatgt atctgtatgt atgtatttat ttattttgag atggagtcta gctgtcgccc138300aggctggagt gcagtggtgt gatctcagct cagtgcaacc tccacctccc ggcttcaagc138360aattctcctg cctcagcctc ccgagtagct gggattatag gaacctgcca ccacacccag138420ctaatttgtg tgtggtgtgt gtatttagta gagacagggt ttcgtcatgt tgtccaggct138480ggtctcgaac tcctgacttc aagtgatcca cctgcctcgg cctcccaaag tgctgggatt138540acaggagtga gccaccatgc tcagcctctt ttatttattt ttaaatgtgg tttagctgtt138600ccgcaggacc attctgatgt tctccatata attccatttt tgctatattt ggtttcagtg138660aaaatgtaag gttttgaaaa agtgaagtgg ctcaagagtc atgctttatt ctggtagatg138720gatttcaaag acgggaagaa ggcatgaggc aaggagacaa acccagatgt acatttaata138780atgagtaatt aatactttat tgattatgtt ttcctttatt ttataattct aatgaactga138840cgccaatatt tttaaaaagc aagataatga tttgaagaga gttagccatg gcagggaaag138900catgaatgga aaagagattg tgctgttata gtgacagtgc ctggaaactc attgaacctg138960acagtgtaga aagatgatgt gagataggca gggaaagaca gtagtaaaaa tccaaaattt139020aacgtacgga aacaaccatg tctgtggcca ttccactctg aacacgccga tactgtctga139080tctcagaggc taagcaccgt ccagcttggt tagtatttgg atgggaagaa acatcttctt139140ccccaattcc tttttagtta ccaattatat ctattacttt tatgaatgtt aagagtctac139200attgagatta gattagcatg caggggtatg acaatctttt aatggagaag gtaacttctg139260
gtatctataa actggagaaa aagtgattct tcttacaaga aataaactgc agatgcaggc139320actaatagac tgaagcaata actctatttc cctcttttga tctttgaagt atctatatca139380aaaaaatctt cttggtggtg gggatatact acatggagat gggccaaaga ctacaaagag139440agacttaggt aaaatcttgt ctttgtatga ggattctact tgaattcaat aggcctgtgt139500ccctaaagaa aaaaaaatgt atttattgca aaccaattta gcttaagtaa aggtacacat139560tttggggttt tattggttgt ggttgttcag ttaaattata cttactgtac tggacaccat139620atacgccaat cactgttatc aattctagga atgcacaaat gaataaaata tggtccctgt139680cttttctatt ttctgtgaac tttctactta cgtcacaatg gtgcaatggg aaaagaagaa139740atggatcatt tattcaaccc ttgataaaag aaagacccct cctagttagc atggtggtag139800cagggataat ctgtaaggaa acctaaatcc aatgtgaacc tctgaagaaa gtgaggatgg139860ttagagtaat ctagtcttgc ctccacatca ggacatactt gccatgacca gcctgggagt139920gtctattttt tttccccatt aaagagggta gcatttcctt ttagttaata ctgagattcc139980cccctagaaa ggttctaata attgtagtgt aacaaagtta gtatcaggtt aatatccact140040ttaatgggag aatttccaaa actaatatta tcagttttaa tgataccttt ttgatttacg140100aaatgtctgt tattcacata gtttttgtta gcagtcaaaa ccaacaaaaa tatttgatga140160acccagataa atatttgaga aacttgtatg ctataacact tcattttaaa agatatgtat140220tttgtcatct ccaagttttc tttttaaaat tgttattcca acccttcttc ccctcaattt140280accagcatca ctaaatgccc accttatttc ccagtagttt atgtgttctc tcatatttta140340aaaaggtttc ttgaggtata atttacatat tataaaatta tttatttatt tatttaattc140400atttttaaat gtggtttagc tgttccgcag gaccattctg atgttctcta tgtaattcca140460tttttgctat atttggtttc agtgaaaatt taaggttttg aaaaagtgaa gtggctcata140520aagagtcatg ctttattctg gtagtgtatt caggtgtaca cccattttaa gtgtacagtt140580
caatgaaatt tagtaaattt ttataattgt gcaaccatca ccacaatcca gttatataac140640atttcagtta ccaagaagtt tccctcatgc ccctttgcag ttaattcttg ctcccgctgc140700agccctaaca acagccacta atttttctgt ctctataatt ttgccttttc tagaaatttt140760gtataaaagg aaccatacaa tatgtagtct tttgtgtcta attatatttg tatgtttttg140820aactattaac ttgccacatg tattagtact ttgttccttt tattgatgag tagcattcca140880catttggata tattttgttt attcagtcat cagttgatag atgtttggat tatttctagc140940atttgcctat tatgaattgt tctgaacaag cgattatgaa taatgatttc tcacacacaa141000gtgttatgta aacatatgtt tttatttctc ttgggtagat acctaggact aaaatttctg141060ggttatatga taagtatatt cttaactttt aaagaaacta ccaagctacc acttttccaa141120tgtgtacgta tcattgtgca ttgccaccag caatgtaaaa tggtttttct acactcttac141180caacacttga tattgttagt tgttttgatt ataatcactc tagttggtgt gttgtggtat141240catcttgttc aatatccatt ttcccaatgg ttacttatgt tgaacatatt tttatacgct141300tttgcatatc tttttcaatg aaatatccac atcttttgct catttttata ttgggttatt141360gtcctcttgg attgtaaaag ttcttttttt attccaaata caagcccttt cctagatatg141420attggcatat attttttccc agcctgaggc ttgtctttgc tttatcttaa tggtgtcctt141480aaaagccatg cttgtgtaaa catatgtatc cacaaacata aacactgtag gagttttatt141540ttgttttttt atcttattaa aatggaactg actctatata cttttcagca tcttgatttt141600ctcattcaac attacctcat agaaattcac ccattagttt caatttatta tttttaatga141660ctgcatacta tttcatggta tgcattcccc cactgatgag cattcaattt gtttctaggt141720ttattccaca cccccaacag ccagtaaaac aataaccaca tttgtaccca tttatagatc141780cttaagtacg ggtgcttttt atttctgtag tttcaagtcc aggagtaaaa tttttggctc141840aaaggcttat atggttttat tttgatttat gttgccagat ggctttctga aacgtatgtg141900
ataattcact tttctcccaa atgtgtgggc atcctttctc ccatatccac ttaagtcagg141960gagctgtcca ttttcaaagg ttgttcagtt aaattgttca gttaaatgtg actgggcatt142020tgcattccta tcatgactag caaatttggg cattttcacg tgtttgctag ttgactgaat142080ttgctcaatt gttaacttca gtttaaccct ttataaattt ttcctttggg tgttttgtct142140ttttttttta gaatataaat atatttggaa ttgtagatat tgggttttgt catttgaatt142200gcaaatattt cttccagttg tattgtttga ctattggttt tgcttttgat ctcccttgct142260acaagaattt ttaaatttta ttattcctag tcttgaaata tttgtaatat cattactata142320tattttctaa ttctttaagg tgggtactag attcctttat ttttgtcttt ctcctttaat142380aaaggagtag tgtcctggaa gtgataacat cccagtatca aacacctaga gtccagatct142440tggtttctga aggtcattta cttctaaaaa gaaccaagag tgcttggaga aatggctgat142500tacaggttgt ggccaagaaa aaacaatcag atctgaatta ttttgtggcg ttagaaacaa142560ggaagtactc agagactaat ggagggagtc atgttaaaag gactcagaaa tcacattcaa142620ggagccactg ctggtctact ctggaaaaaa tttgaatacc aaaaatagag aataaataac142680aatgatggta aaggatcaca aaacatttga ataaacaaaa aaaaatcttg agtcagcaga142740gatattccaa aaaaatgaga gactaataaa tgtagggaaa acatgtatat ttaagaatca142800ctattgcagc tccagtataa catttgatta ggcaagaaca tggacagagg ctaaaatttt142860ggccattaga ttgttgggga acacggtagt ctcacaagga tacaatgttt gataaggttt142920ggctgtgtgc ccacccaaat ctcatcttga attgtaattc caaatgttgt gggagggact142980ggatgggggt aattgaatca tgggggcggt ttctcctatg ctgttcttgt gatagtgagt143040gagttcttat gagatctgat ggttttataa atatcttgca tttctcctgc tatcatttat143100tctctctcct gctgccctgt gaagaggtgc cttccaccat gactgtaagt ttcctgaggc143160ctctccagcc atgtggaact gtgagtcaat taaacctcta ttattgataa atcatccagt143220
ctcaggtatt tcatcatagc agcatgagaa cagactaatg cagtaaattg gcaccacaga143280gagtgatgtg ctgctataag ggtactcgaa aatgtggaag tggctttgga actgagtagc143340aggcagaggt tgaaacagtt gggaggactc agaaaaagaa aggaaaatat gggaaagttt143400ggaacttcct ggagacttgg agggctcaga agacaggaat atgtgggaaa atttggaact143460tcctagagac ttgttgaatg gctttgacca aaatgctgat agtgatatgg acaatgaaga143520ccaggctgaa gtggtctcag atggagatga ggaacttatt gggaattgga gtaaaggtca143580ctcttgctat gctttagcaa agagactggc gacattttgc cctagaaatc tgtggaacat143640tgaacttgag agatggttta gggtatctga cagaaggaat ttctaagcag caaaccattc143700aagaagaagc agagcttaaa tgtttggaaa atttgcagac ttatgatgca atagaaaaga143760aaaacccatt ttctgggaat tcaagcctgc tgcagaaatt ttcataaata acaaggagcc143820aaatgttaat caccaagaca atgaggaaaa tgtcagagac cttcacagca gcccctcgct143880tcacagaccc agaggcctag gagagaaaaa gtgttttgtg ggccaggccc aagcgccccc143940cagccctgcc ccccggcagc cttgggacat ggtgcccagt atcccagctg cgtcagctcc144000agccttggtt aaaaggagcc aaggtacagc ttgggccatt tcttcagggg tactagcccc144060gtgacttggc agcttacatg tggtgttggg cctacgggtg cacagaagtc aagaattgag144120gtttaggaac ctccacctag atttcagagg atgtacagaa acccctggat gtgcaggcag144180aagtgtgctg cagcggtaga gccctcatgg agaacctctg ttggacaata cgaaagggaa144240atgtggggtt ggagcctcca cacagagtcc ccagtggggc actgcctagt ggagctatga144300gaattgggac acaattctcc agaccctaga atggtagatc tactggcagc ttgcaccatg144360tgcctggaaa agtcacagac actcaatgcc agcctgtgaa agcagccagg agggggcggt144420accctgcaaa gccacagggg cagagctgcc taaggctgtg ggaactcatc tcttgcatca144480gcgtgacctg gatatgagac atggagtcaa aggaaatcat tttggaactt taaggtttaa144540
tgactgtcct attggatttg acttgcatgg ggcctctagc tctttggctt tggccaattt144600ctcatttgga atggatgtat ttacccaatg gctctacccc attgcatcta ggaagtaact144660aactttcttt ttattttgca ggctcatagg tggaagggat ttgccttgtc tcagatgaga144720ctttgaactt ggacttttgg gttaatgcta gaatgagtta aaactttggg gaacctttag144780gaaggcatgg ttgtgtttta aaacatgagg acatgtgatt tgggaggggc cagaagtgga144840atgatatggt ttgggtgtgt cctcacccaa atctaatctt gaattgtaat cccacgtgtc144900atgggaggga cccagtggga ggtaattgaa tcatgggggt ggtttcctcc atgctgttct144960tgtaagagtg agttctcatg agatctaatg gttttatgtg tctggcattt cccttgctgg145020cattctctct ctcctgccac cctgtgaaga ggtgccttcc tccatgattg taagtttcct145080gaggcctctc cagccataca gaagtacgag tcaattaaac catttttctt tataaattac145140gcagtttcag gtatttcttc atagcagtgt gagaacagac taatacagtg ttacttcata145200aattgcttac taatcgaaaa ggggaaaatg tattaatacc tttaagatag aaagatctgg145260caagtagaca aacttaacgt tgcaagtaat agaacataat attttgtttc tcctctgcta145320tgcagtataa agtacctaaa tcattaccaa caaactatgc ttaccaaaaa tgtttattct145380aaataaagca tctactgtgg ttctcattta tatagtaagt ataggaatta gagaaacaaa145440tgaagtagca ccattatgca tcaatcagac aaatccatga tttgggacat tctctaagtc145500aactaatttg gctcttttag aaagtgaaag tcaagagaaa ataaaaatgt aggaggcatg145560gcatggtggc tcacacctgt aatcccagca cttagggagg cagaggtggg tggatcactt145620aaggccggga gtttcagatc aacctgggca acatagtgag aactcgttct cttaaacaac145680aacaacaata aactcttgcc agcagaggtg tgctattaaa aaaaaaaaag taagagaact145740atcttgatta aaaatgattt cagagaaata atctttattg caatatgaga atttttcttt145800gaatactgaa gttgttttta aagatataaa atttattttg atgaaaattg aggaaacttt145860
aatatggact gaattagatg acatgaaatt attattaatt tttaacaatt gtgataatgg145920tattgtactt atgtagaagc atgcccttat taggatatgt gtgctgaatg taggctttaa145980ttgctgcaaa agtcttcctc atgtaaagtc aaaatttttt aggtactaac tattggtctt146040cgttccgcca actggagtta aaagcatcag ttgatactgt cacaagaaaa ttatcttctt146100tgtattagta aaataattaa aattaaaatg tatatataca aggcagagaa ttacaaaatt146160tgggtatcaa tactactata ttaattttat gctactatag tatatgccct tttagatgtt146220taatatctgc taacagatat gtttaggtag aaatgatgta tatcaggtat ttctcaccat146280ttagatgcca tgaagttgct gtgaattaaa taaacatttg tttggtaaac tgcagtaacc146340tattttaaag tgttctttaa aaggtatgta taggccaggc gtgatggctc acacctataa146400tcccagcact ttgggaggct gaggtgggca gatgacgagg tcaggagatt gagaccatcc146460tggctaacac agtgaaactg cgtctctatt aaaaatacaa aaaattagct gggcgtggtg146520gtgggtgcct gtagtcctag ctactcggga ggctgaggca ggagaatggt gtgaacccag146580caggcggagc ttgcagtgag ctgagaccgc accactgccc tccagcctgg gcgacagaac146640aagactccgt cttaaaaaaa aaaggtatgt atatatacat acatgcacag acacatatat146700atttgtgtat cttttttaag attatatcta ttttatatga tgattatata ttatgtgata146760tattattata caataatata ttctataaaa ctattttttc ttcaatttat taaaatatta146820ttttcatgta atcctggcac tttggcaagc tgaggtggaa ggattgcttc agctcaggag146880tttgagacca gcctaggaaa cataaaaccc aactcataaa aattaaaaat atgtatactt146940ttcggtttta tacttgacag gctttacaag aatttcaagg agatataaaa ataatgcaaa147000ttgtctggaa gaactcgcct ctcctctcct tactccaccc tgctattggg aaaaagatta147060actgatggtg agtggtgagt ctataatacc atcactccat gttcctggat gttaaaagtc147120actcacacat gtgacttctg tctttacaac acatgaagta ggtaaggcca gaattctgct147180
tccagctaac tgggagaggt agtctgttcc caaagactta aaatatcctc aggtcaggag147240tttcaaagtc tacacttaga gggaagaacc aggaagtccg taaagtcata ggtttcaacc147300gcatccttca atttagtatt tctaacaaca atgctggtat tttgatatcc atctctttaa147360tacctgcttc tatttccaac ttgtttagaa cttgaagagg gagataaggt ttaattttgt147420gccttcccca agcccagcat ttagggatgc agagatatta tgtattttaa gcatgtgctg147480tagtagccaa tgggaatcca gaatgttgtt gtttatttgc attttaattt actacagaat147540tgttgatttt aggccctttg atccaatgct aatttaaatc attttcaata gaacattgtt147600tatttccctt catgctttat aactctaaat aataaaaaat accatctttc actttaaagt147660ccatattctc caggcattat ttttgagctt cacataggct tagaagaaaa actgatcaac147720agtagtgatg tggtggttgt ggaagcagtt gcatagctta gatagctcag gttttaaatc147780tcacctttgc cttatgttaa ctgtgtgaac aggttaaaat tactttgatc tctctacacc147840tgtttccttg tatgtaaaat gagagtaaca aaagagtagc tgggaagatt agtgagctaa147900gacatgcaca gtgattacca tgtctcctgc catatacgcc tcaaaaattt agctcttatt147960atacttgttt ggttcatagt aggtgaagtg tttggtagaa aaattgggaa ttcattcctt148020tcttgattag agtgaatgac aatccatttg cagaaagctg cagaaagacc gctccagaaa148080tagaatgagg caaccgctct ggagaattga aaactaacgg gagctacgct ccacaaaaga148140taaggaaata aaaatgccag gaacaatatt ctgagaagaa gggaaaacaa aagaacagaa148200aaattatcag ttatatagcg gggaaaaatc tgaaaggaaa aaatctcaag agaaggggac148260taaagaagta taaagctgat tattctatat tgatcgaccc atcaatgtgc taatcaagca148320gtaagcagaa ggttgcagga tggaagtatg gattcttcct gaccattcgt tacgcagtag148380atgctttctc tacttaatga caacagcaat aggcaactgg aaaatgtcac ttagccagca148440tgtccaaatc catcttcctt gactttcctg gtgaaaccac atattttatt ctagatatca148500
ggttgaccat agaggtaaga catgcagtgc tttggagttt gtattttctt tttttttccc148560tttctttttt tattttttat tttttttatt ttttgagact gagtcttgct ctgtcgccca148620ggctggagtg cagtggcacg atctcggctc actgcaagct ccgcctgctg ggttcacgcc148680attctcctgc ctcagcctcc cgggtagctg ggactacagg cgcccgccac cacgcccggc148740taattttttg tatatttagt agagacgggg tttcaccgtg ttagccagga tggtcttgat148800ctcctgacct catgatccgc ccaccttggc ttcccaaagt gctgggatta caggcgtgag148860ccaccgcgcc cggcctggag tttgtatttt cttaattctt ttggttggta ctttgcagat148920ttggggagca acaattggtg agaaaaacaa tagtattaac atatgtgaaa attcagctgc148980tacctttttt atgtaaaaat aattcagctt ttcaattata tgctttcagg tataatctgt149040tgtttctata gcatcattag tggcagtatt taaaagtctc taagcctgac agttcacttc149100gacagatgca aagaacaata agcactgatt ttcaataagc taataagaag tagtttaaga149160aataaattgg cttaatttga gtttacaata atctaaaatt ttgcaaagat ttatttattt149220acatatcaca gtgtgctttt gaattagatg tttcttagac taatatgctt attttcagag149280gattacaagg atgcagtaga cagcattcca tttgatgtac atagctgcga atacatttaa149340cattgaaagt ttcaagcact ttcttttaga atttggattt ttcatttcag tctttctagc149400aagataactt agagatatgt atgagatata aagtaaatga caaaatagaa tgctatatgg149460aggaaaattt gatgaaaata taattgattg agagattttt gttgaacaaa tgaaaccaac149520gattttttcc ccatcagaaa ctaattgcat ttctttctta tttccttgga gacacatgtg149580gaataaaatg taataaatac tgtacttgtg tgtttactta ccagaatgtt ctcttcagaa149640aaagtaatga taccctttca ttgacatcat ccaagtgata atatactttt gtttctgtca149700ttggagtaat aataaccttt caaccacatc actgcacagt gcttctttct tttattgtac149760ataatgcata aaaataaaga gggtatatta tttcttaagg aaataggttg ttatttaaat149820
aaattccaag catcagaaaa ctacagttct tgctgatgtg tactaaaatt tctatagata149880cttataactt tgtatagaaa tttaatttta atattctttc aattgtcaca tcatacttaa149940gtacggatct ccactatttc acatctcaaa aatatgactt aaaaccagtt atagttgttt150000ataccccgat gataagggat tagaattttt ttttgccaaa tactccttag gctaagtttc150060aaagtctggt ttgtataaaa tattactagc agataaatag tttgttaata aaacatccaa150120gcttgtgctg atgggtgaat ttgctataat gtaataaagg ctgacactac tcatagtgag150180aatttaacct tttcctcaga ataccttatt catttaaatg aactcacagg tttaatgtaa150240aatatttcat atatatttga tacgatcctg tacaaattgt ttcctagcat aataaattga150300atacagtgtg aaataaattg tgactttgtt ttttttactt agtatctcaa gtttgaagaa150360tataagttct ttatgttttt gcttaagttt gatttacttt atcattaatc ataataatag150420gatttgtgct ggatgatgga aatccaaacg gtgttactca gtataataag aaaagtgaac150480tacatatgga atgtttaaaa taaagaacta atcttaaacc aatcagattg tttcatgatg150540cagacaggaa tctcaggaaa taggcttagt ggaattttct ggcaattaag tataaaattt150600tacatgcttt aagtaaatat ttcttaaaca agtgtctatt tctggtctca ttccactctc150660caaagagttt catctgagct taataatgtt ggtttgaagg catacttgca aatagagggc150720agaaatgtta actctatttc cagatttcta ctattgcaaa cagtctctaa gttaaagcca150780aagttgtttt ctattttatt ggagcaaggg aagcctgatt aaagcttttt ttagaataca150840tattcactca gcagagcaag aaaacaacct caagactgac atagctgttc taaaagtcat150900cttttggttt tattgttgga aagagggatt gctcatcaaa tcactgataa taagaatgct150960tagatgacgc tgttatgtag ttgatgttac ttagcatgcc aagtctcttt ctgtacatat151020taaaagtgat acgttgttct cagccaagac taataaattt ttttctggta acagctttat151080tgagatataa ttcacaaacc atacaattca cccactgaaa ttgtacagtt cgatggtttt151140
tactatattc acagttaatg caaccatcac tgcaatcaat tttaggacat tttcgtcact151200ccaaaaagaa atctcgtatc tattagcaat cgctccttat ttcctcctaa ccacccctca151260cccaacctct cagctctagg caaccactaa tttactttct gtctgtatat atttgctatt151320gtagacattt aatataattg aaattatata gtatgtggtc tttcgtgact agcttctttc151380acttgtcata gtgttttcaa agctcatcca tgttgtagta tatatcagta gtatatcaat151440gtgttttatt gacaagtgat attccatcat gtgtatatac cacattttat ttagctcttc151500atcagttaaa ggacatttgg gttgtttcca ccctttggct attatgaata atgtcgctat151560gaacatttgt gtacacattt ttgagtggac atatgttttc acttctcttt ggtatatgcc151620aaggagtgga attgctggat tatatagtaa ctctatgatt acccctctga ggaactgctg151680gacagttttg caaagaggtt gtgccatttt tcattcccat aagtgttata tggggattcc151740attttctaca tgtcatcacc aacacttgat attatctgtc ttttttttat tatggccata151800ctgatggggg tgaagtagta tttcattgtg gttttgcctt acgtttcctt aatgatgttg151860acattcatct tttagtgctt tattggctgt tcgaatatct tctaagataa atgtctattc151920agatcctttg cctatctaaa aaattgtgtt gtctttttat tgttataata agagatcttt151980aaatattctt ttatcaattt tgctttgtgt ggtttactaa ggtaaaaacc ttgggtgtgc152040aattaataca ttcaattgtt agcaaaatta ttaaaacaat aacttataat ttttggtcca152100cctgaaatag ggaaactaat ttgactcaac ttttctttca attgttgtgg agtctggttg152160actgccaaat tttgtaaatt ttaatatttt acccagtaaa aagcttatta aataatagga152220tatactgatt agaggttact ttcaagaaat taaatatttt tgtgtcttca gaaagagttc152280tccttttgga aagatactat atggataaag aagtaaattt taagtacata tttttttaaa152340gtgcatcagt tattatttaa aggaacattt aaattttagc atttgagcag ctatctttcc152400tccttcaaag ttttctcatt atcctttcct tgtacgtatt attatttata ggctgcaaat152460
gaaacctaaa agaacataaa tggttttcta tttcaacaaa agcaatcacc tccacgtctc152520actttcttat ctttaattaa ataagtaaga taaaaagtaa aaatcatggt tgcccctttg152580gttttgctgg tctgacccat tatcccagca cattgtggta gagatataat aagcctgctt152640tgcctagaag atcacttagg aacaaccaag gcttggggaa gaaatcagtt gccactaaaa152700tgtcaaagta tcaagtattt ctgcatgtgt aactagagga aaaggagaga agacagcagt152760gcttctgatg aggcccaaga tctctggcat ttgaaagaaa ggtgaaagct gttgatggtc152820actttctttg ggtctctttc cttgggtcag gattgtacat gaaagtcgct ttagatacat152880tggccagaaa gaatgtgtgt agcctaacac aaacgtgacc tactttttac gaaaggaaga152940aattcttggg aggtataact gaaaattatc gtcccaattt acaaactcac tggacagtat153000gaatttctct tagggctcct aatctatttc agtcagacag taagtcttcg ccatgaaaac153060aaaacgaaat ggactataaa actgaacagg ctgggcttag ttatagatct gattgtttgg153120ctatgtgcag ggaaccagca tttaaaaaat aattccagct ttaatctgaa ataaagcaaa153180gtctgaatgt atggcatagc ttagtgaaaa aataagctca taaatgtcta taaatgcatt153240tataaatata tttaaaaatt tttaaagcag atgcaattct ttgtcacaaa tacggatgtg153300attctaaata tcagcaagtt tctgctaaca aaaagatgca aatgaaagtc atgatccaaa153360acctgggcat agtaataatt ctggtatctg gtttgagttt tagctccttt cttagctgtc153420agcaaaatca tcctctgaac ttctcactct tatgcctgcc cgtctttatt ttaactcata153480gacaagcagt tggaattttg ccatttaaca gccaagccct gtggcaggat aataagtaac153540agtccactaa catgaatgca gagaaaagca tatgttaggc caggagggat gaaaattgtc153600cacatagaag aaaaaataga aaaagcaaga cagaaagaaa aagataaata aaaccttaag153660ggcaagaatt ttctgtttac aaatatgctc tcctttagcc tagcttttac aagtgggtga153720ctgcattttg cagtcttagt aaatcacgac tgcttaacca tgcatttaaa gctattaaat153780
taagttacca acagccaatc ccccaaaact tatatgcatg aaaagacata aaaataaaat153840aaaacaataa agaaaatttc ttatttaaaa tttaatgttg atatgattaa aaacatatat153900caacatctta aaagcaatca gacttcataa tcaaggagta ggcatgttat aataaaaaca153960agctctagtt tcatttctgg tgcaggttta atttattatt atttttttaa aagctgaaaa154020tggtaggagg tgattcattt gtttggattg aggactacat ctggttcaga gttaatagtc154080atctaaaagt aaagtatcat ttgagaaggc ttaggggtat gccggaagtt ttaactttta154140catcatttgc taatgtgcta gttatctgga agctattaaa ttagaatatc tgattttgct154200gagattaaaa agaaatatta gacccatagt taattttttg tgcagaacgc ttccattata154260ttctgccaag ttttaaacat ccaatgtaac agcctgtttt tgtttttttt gctttaggaa154320atgttcttca atttgccata taggaaatta aaaagtataa catttgaagt aggataatgt154380tctgagctta tgttttacaa agctttgaac attaaaactg ttcatggttt aaataatttc154440atggttaata tttgtgatgt ataaattcac tggtttcctc tactatggca tgttaaattc154500caggtaacct atatctgaag aagaattagt tgtaacaaag attttttttt taatctttct154560cgaatgggaa gatccatata gtataggaaa ttgtgagaat actaatgaat tactcagaaa154620taaactaaaa ttgtgaaaaa agtaaagaag ttagagatga gagaatgtca tgaccaacga154680tggatttaga cttaattgcg tatttggcac attgaagtct aagtccattg ttggtcattt154740ataaattttt agactgcagt ttttaatatt tggttttctc ttcattttcc tttcctaaaa154800ttatttcctc ttcttccttt tcatctcttc ttttattcct tgtttcccag tgaaattatt154860ttctagcaca gcaagacatg gttccactct gaggcgaatt ttaagatgcc gatgttattc154920tatttggttt tgcaagctca gggcacacat atacgagtgt gtggagtgtg tgtacgtatc154980aaagaagttt ttattctaag aaaattttga atataagttt gaatttatta cttttctctt155040ttgcctagta tgttatacaa attctacata gttttagagc caaattacag caatcagttc155100
acaatccctg tgatcatatt attttcttaa aatttcttgt ttatttgaaa tgactatatt155160gacttatttt agctgaaata tagtcacaaa cagatcctct tgtaatgctt ttctcaagat155220tccagctgag aaactgcaaa tatgaaaata ccacaactga tttcttcaac tacttattaa155280atatcatctt aagttacagt tcaagatcaa cttctttggg acaagcaact atttacttat155340gtatgagatt tttaaaaata tcgcttatga ttgttttggt gtatgaagga tcctgtcacc155400caggtagtaa gcatagtatc caaccaaagc tcaggaacat gcagtttacc catgtaacaa155460acctgcacat gtaccccctg aactccaaag tcgaaaaata aaattaagtc ttccaatagc155520ttgttcttta aaaaaaagat tgtttttaaa ttttggaaat aattttctat tgcaacagta155580ttaaaagaat gggacttggt ccaagaataa ctcccaaact ggttgtttat ctcataataa155640agctgaattg tggaaatcta gaacctaact tcaatacatt gttttccgag aaaaaaaatg155700gaacactctt aatttatttc tgatttatca gaattttgct ctccatgtgc aatccaattc155760ttacctctgg atgcatgacc tcatagggga aaaaaattgt tcatttctgg ctcgccacaa155820tttcatgctc attttaactg agcccttacc agtgcccttc tattttaatt tatctgttgt155880tggttctcta acaaaatatc caaaggagta gctgccatga atattttatc tttccaattc155940catattccct tccttctcaa cttccatttg tattcctcat caaatgatta ttctccctgt156000tgatgtgaaa agatttagga cactttccct cctcctcagc ttgtcaactt gtgatttcct156060ttgatttcag agaaagagat gattcttcta taaaaccaac ctatctctct gtccttgacc156120cagcttctcc tgtttcataa gagatattac tcttatagat cttcttttct agtctttaca156180tacacatttg ttccctcatc cccctctggc tactgtcctc tttcctcttt tcctttagtg156240aaaaatgtct tccatgtccc ttgcatctgt atcaccctgg atgtaagttc atttaattgt156300tttctctttt tccctttcta cggagattgc cttctcaaaa tcaacttcgt gtcagctcta156360gcagtcacat attcactctc agtctggtta attctttagt gcatttcaca acttaaaact156420
gtttttttct tgacttctgg gaaagcacat tatattgccc cataatactc agattcttct156480cttactacca cctaaatgct cagtcttttt catatattcc ttttcactcc tctgtgtgtt156540atctctacta aatatgaaat ctcagcgatc tcatctaccc cattactgca actctccctt156600ctatgtgaaa aagcccaaaa taataatcat ttcccatttt caaagagctt ttccttggat156660acttatattt aatctttaat aagaatttat gaggtagata cattcattac acagactacc156720aaattcacat tttcagtttc ctactatttg gtcattctcc ataagtcaac tagatattta156780ctgcacttag gcattcactg tggtgtagta atgtatcaaa aattaagtct attgtctttt156840tatgtcccat ccagtgtccc ttctcaacct tcctgttggt attaaattgg ccaggctact156900ggccaagtct gttagttcaa agtcttaaga gtaagcttca tttcaaacag tagaggcttc156960caatgggatg aacttggatt attatctgtt ggtgaccctc cccactgtca actcatcctt157020tagaagccca ctcaaatgcc agctccttca agagtcatca ccttatcgca atgctcctag157080gaacattttc acaactctgt tcctgtggca ctttttgtct ccatcctgat attgctaaat157140agtgtggctc tcagacctcg gggtgttggg tcagacaggc tcgtgctcca gtttttgtgc157200tgccacttac gaggtggatg acttgttgca agtcaccttt ttaaagcttc gtttttccat157260attggtacac agtgttcatg atcataatgc ctagtttgtg ggatgtttaa aaagattaca157320tcagataatc atacgcggaa ctggaacata ctaaatgctc aaaaaattgt tagctaactc157380actttctata atgtaatatt ctgaacacat gcagaacctg acttttaaga tccagttcct157440agttttgtgc ctgaggcttt acaatgctgt gatgctgtga tctggtcatg acttagaata157500ctttgattat ctctgctata caatggaatg tattataatt taaataagta tttgtggggc157560tggatgctat ggctcatgcc tgtaatccca gcattttggg aggctgaggc ggatggatca157620cttgagatca ggaattcgag accagcctgg ccaacatggc gaaaccctgt ctctactaaa157680aatacaaaat taagctgggt gttgtggcat gtgcctgtaa tcccagctac tcaggagagt157740
gaggcaggag aatcacttga acccaggagg cagaggttgc agtgacccaa gatcgcacca157800ttgcattcta gcctgggtaa cagaaaggga ctccatctta aaaaaaaaaa aaaaaaaaaa157860aaaaaaaaag tatttgtggg atagatggaa aaatttctat aaagatgttc ataaactatt157920cttgctaaat tgtaaacaat gattaaaatc aagcatttga acagcagaat ctgattttgt157980acatctttgc attttgtata ttacatgagc aaaaccaggg tggattatat ttaaaaattt158040tagttatttg ttgattgaat ttactttgat gtcaatcctc catttcttat atatatgcac158100tttccaaatc ctattgatca aaaaaatgaa aaatctcatc ttcattaccc tgtaacccaa158160agccactcct ctaatcagac cccaactccc tttaagaata accataagtg tctcctactt158220ggccctcata cctccagctt ttaactctat taatccattt attacaatga tatacaatag158280ataatcttct gtaaacactc atttgaccat gcccttccct tgtttaagaa cttgcaatga158340cttgcttttt cctagcacag caaagctaaa tttctccctt gaattttaaa atcctccatc158400tgtttctact cttcctatgc aatattattt tccattattc cttaacaagc ttccaccatc158460ctactgagac aggtatattt tttgtctcta gtaaactagg ccctgaagat aaaaatttgc158520ataaaatatt cagtagcatg ttccttattt tgctctcacc ttctatgctt ttacacatgc158580tatttaagtc tcctggaatg ccttctccta aactccatga cccaatacac attttttctc158640ccctgtcaac tatttcttca tgaatctccc ccctcttaat gttgttacat agtctctaaa158700aataatctaa aatagatgat ttagtcatgt ggaataagat tcagaaggta tcccaggcca158760tgtagttaaa gtctcttaac ctcagcaaca cgcctgccag attccctcct tctctgagag158820atgttctcta tataaacaaa tattatatat attcttccct tatttctctt tcgcccctct158880ttttaataca aatgatggag ggagtatcga agctgtccct aaagaggtca caattaagca158940gaaacctgaa agaaatgatt gagcatatca ggtaaggatc 158980
<210>33<211>405<212>DNA<213>人<400>33cttgttgcta ttttagaagg tgtccagtgt gaggtacagc tggtggagtc tgggggaggc60ttggtccagc cgggggggtc cctgagactc tcctgtgcag cctcgggatt cgtttttaat120gtgtattgga tgagttgggt ccgccaggct ccagggaagg ggctggagtg ggtggccaat180ataaatcaag atggaagtca gaaatggtat ctggactctg tgaagggccg attcagtatc240tccagagaca acgccaagga ctcactttat ctgcaaatac acagcctgag agccgaggac300acggctctat attactgtgc gagaggagat tactacgact atagtggtaa ttacattgat360gcttttgatg cctggggcca agggacaatg gtcaccgtct cttca405<210>34<211>1749<212>DNA<213>人<400>34gatttgctct gccagcagct gtcggtgccg cgctcgacac cgagtcctag ctaggcgctc60acagaatacg cgctccctcc ctcccccttc tctgtccccc gcctctcgct caccccggcc120cactccagcg gcgactttga gggattccct ctctggcggc ctctgcagca gcacagccgg180cctcattcgg ggcactgcga gtatggatct ccaaggaaga ggggtcccca gcatcgacag240acttcgagtt ctcctgatgt tgttccatac aatggctcaa atcatggcag aacaagaagt300ggaaaatctc tcaggccttt ccactaaccc tgaaaaagat atatttgtgg tgcgggaaaa360tgggacgacg tgtctcatgg cagagtttgc agccaaattt attgtacctt atgatgtgtg420ggccagcaac tacgtagatc tgatcacaga acaggccgat atcgcattga cccggggagc480tgaggtgaag ggccgctgtg gccacagcca gtcggagctg caagtgttct gggtggatcg540
cgcatatgca ctcaaaatgc tctttgtaaa ggaaagccac aacatgtcca agggacctga600ggcgacttgg aggctgagca aagtgcagtt tgtctacgac tcctcggaga aaacccactt660caaagacgca gtcagtgctg ggaagcacac agccaactcg caccacctct ctgccttggt720cacccccgct gggaagtcct atgagtgtca agctcaacaa accatttcac tggcctctag780tgatccgcag aagacggtca ccatgatcct gtctgcggtc cacatccaac cttttgacat840tatctcagat tttgtcttca gtgaagagca taaatgccca gtggatgagc gggagcaact900ggaagaaacc ttgcccctga ttttggggct catcttgggc ctcgtcatca tggtaacact960cgcgatttac cacgtccacc acaaaatgac tgccaaccag gtgcagatcc ctcgggacag1020atcccagtat aagcacatgg gctagaggcc gttaggcagg caccccctat tcctgctccc1080ccaactggat caggtagaac aacaaaagca cttttccatc ttgtacacga gatacaccaa1140catagctaca atcaaacagg cctgggtatc tgaggcttgc ttggcttgtg tccatgctta1200aacccacgga agggggagac tctttcggat ttgtagggtg aaatggcaat tattctctcc1260atgctgggga ggaggggagg agggtctcag acagctttcg tgctcatggt ggcttggctt1320tgactctcca aagagcaata aatgccactt ggagctgtat ctggccccaa agtttaggga1380ttgaaaacat gcttctttga ggaggaaacc cctttaggtt cagaagaata tggggtgctt1440tgctcccttg gacacagctg gcttatccta tacagttgtc aatgcacaca gaatacaacc1500tcatgctccc tgcagcaaga cccctgaaag tgattcatgc ttctggctgg cattctgcat1560gtttagtgat tgtcttggga atgtttcact gctacccgca tccagcgact gcagcaccag1620aaaacgacta atgtaactat gcagagttgt ttggacttct tcctgtgcca ggtccaagtc1680gggggacctg aagaatcaat ctgtgtgagt ctgtttttca aaatgaaata aaacacacta1740ttctctggc1749
<210>35<211>2320<212>DNA<213>人<400>35ctcagctgca gttctctgat ggcttgcaca gggtggacca gcccccttcc tctatgtgtg60tgtctgctgc tgacctgtgg ctttgccgag gcagggaagc tactggtagt gcccatggat120gggagccact ggttcaccat gaggtcggtg gtggagaaac tcattctcag ggggcatgag180gtggttgtag tcatgccaga ggtgagttgg caactgggaa gatcactgaa ttgcacagtg240aagacttatt caacttcata taccctggag gatctggacc gggagttcaa ggcttttgcc300catgctcaat ggaaagcaca agtacgaagt atatattctc tattaatggg ttcatacaat360gacatttttg acttattttt ttcaaattgc aggagtttgt ttaaagacaa aaaattagta420gaatacttaa aggagagttc ttttgatgca gtgtttctcg atccttttga taactgtggc480ttaattgttg ccaaatattt ctccctcccc tccgtggtct tcgccagggg aatactttgc540cactatcttg aagaaggtgc acagtgccct gctcctcttt cctatgtccc cagaattctc600ttagggttct cagatgccat gactttcaag gagagagtac ggaaccacat catgcacttg660gaggaacatt tattatgcca ccgttttttc aaaaatgccc tagaaatagc ctctgaaatt720ctccaaacac ctgttacgga gtatgatctc tacagccaca catcaatttg gttgttgcga780acggactttg ttttggacta tcccaaaccc gtgatgccca acatgatctt cattggtggt840atcaactgcc atcagggaaa gccgttgcct atggaatttg aagcctacat taatgcttct900ggagaacatg gaattgtggt tttctctttg ggatcaatgg tctcagaaat tccagagaag960aaagctatgg caattgctga tgctttgggc aaaatccctc agacagtcct gtggcggtac1020actggaaccc gaccatcgaa tcttgcgaac aacacgatac ttgttaagtg gctaccccaa1080aacgatctgc ttggtcaccc gatgacccgt gcctttatca cccatgctgg ttcccatggt1140
gtttatgaaa gcatatgcaa tggcgttccc atggtgatga tgcccttgtt tggtgatcag1200atggacaatg caaagcgcat ggagactaag ggagctggag tgaccctgaa tgttctggaa1260atgacttctg aagatttaga aaatgctcta aaagcagtca tcaatgacaa aagttacaag1320gagaacatca tgcgcctctc cagccttcac aaggaccgcc cggtggagcc gctggacctg1380gccgtgttct gggtggagtt tgtgatgagg cacaagggcg cgccacacct gcgccccgca1440gcccacgacc tcacctggta ccagtaccat tccttggacg tgattggttt cctcttggcc1500gtcgtgctga cagtggcctt catcaccttt aaatgttgtg cttatggcta ccggaaatgc1560ttggggaaaa aagggcgagt taagaaagcc cacaaatcca agacccattg agaagtgggt1620gggaaataag gtaaaatttt gaaccattcc ctagtcattt ccaaacttga aaacagaatc1680agtgttaaat tcattttatt cttattaagg aaatactttg cataaattaa tcagccccag1740agtgctttaa aaaattctct taaataaaaa taatagactc gctagtcagt aaagatattt1800gaatatgtat cgtgccccct ccggtgtctt tgatcaggat gacatgtgcc atttttcaga1860ggacgtgcag acaggctggc attctagatt acttttctta ctctgaaaca tggcctgttt1920gggagtgcgg gattcaaagg tggtcccacc gctgccccta ctgcaaatgg cagttttaat1980cttatctttt ggcttctgca gatggttgca attgatcctt aaccaataat ggtcagtcct2040catctctgtc ctgcttcata ggtgccacct tgtgtgttta aagaagggaa gctttgtacc2100tttagagtgt aggtgaaatg aatgaatggc ttggagtgca ctgagaacag catatgattt2160cttgctttgg ggaaaaagaa tgatgctatg aaattggtgg gtggtgtatt tgagaagata2220atcattgctt atgtcaaatg gagctgaatt tgataaaaac ccaaaataca gctatgaagt2280gctgggcaag tttacttttt ttctgatgtt tcctacaact 2320<210>36<211>2722<212>DNA
<213>人<400>36catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc60acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag120gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt180tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa240cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag300tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga360tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc420cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga480gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt540cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc600atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta660accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat720cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa780ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact840tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg900cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat960tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta1020cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg1080gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa1140aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct1200tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc1260
aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg1320cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga1380acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc1440ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc1500tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa1560ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg1620ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg1680gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg1740ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg180actgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta1860ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg1920gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc1980aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca2040aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga2100gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt2160tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac2220cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct2280cagcctcaga gtcagatgca ggaggaagac acagcaccct ggagatgtta aggcagaagt2340cagttcttct gtccatccct ctccccagcc aggatagagc tatcttttcc atctcatcct2400cagaagagac tcagaagaaa gatgacagcc ctcagaatgc acgttatgag gaaggcagaa2460tgtgggtctg taattcctcc gtgtcccttc tccccctctg caaaccgtcg taacaataat2520agttcctaac acatgggaca attgtgagga ttaaatgagt tagcctgcag aaatcacttg2580
atgcacagca catgggaagc attgtgtgta tttattaatc cttcacaaag tctttgagat2640atatttttat caaatattta gcatggatcc cggtacactt tcaatactta ataaatggtc2700aatgttattc tttttcacta tt 2722<210>37<211>631<212>DNA<213>人<220>
<221>混杂的特征<222>(524)..(524)<223>任何一种碱基<220>
<221>混杂的特征<222>(592)..(592)<223>任何一种碱基<220>
<221>混杂的特征<222>(547)..(547)<223>任何一种碱基<220>
<221>混杂的特征<222>(600)..(600)<223>任何一种碱基<220>
<221>混杂的特征<222>(519)..(519)<223>任何一种碱基<400>37
ttattctcta ccttgttcca catctggcat tttttgtgca tcttccaact taagtacaca60gcagcaagtg ctctacatct ttgggtagct acacagaacc ccactgtggc tcactgtgga120cacaccattg aaaaccttgt atgtaggtca cttagtacaa ggaggaacac aactgttgaa180gaagtaccta aaaattgaat tacttgaaca aagtgtggga catttgctgt tttgatggat240tttaccacac tgtcttccca tttatgctta ccagcaatac ataggaacac ttgggtccct300gcagtcaggg tgtggaaatg gcagatgagt tcagccctaa ggtgcatttt tcttactagg360aggagatgga gtgtatttta tgggatataa gcattagcta catttcctgt cctgttcaca420tcctttgccc atgtgtctat gaggttattg atctttctta ctgatttatt ggtagctctt480acttaagagg taattagcct tttgcctgtg gagagtttnt tgtnttgcca tttgtccttt540tttaatnttt tttggttatt ggcccatttg tcttttggac tctgatgtgg tnttgctgan600ttcctttgat gtattctagt tatctgactt t 631<210>38<211>1761<212>DNA<213>人<400>38gtttagagta ctaggttatt tatgttttac aaagtttgaa tcttctataa actaagaaag60gggatgatcc ttagatttgc attaaaatat agaagtcttt taaagtaaat gtgaaccttg120tctaagtact gtaatccaca caacacatta taagaagcaa accagcatct taaggaatta180taaaattacc ctatttaaaa gccatgctat tgttctgcta ttaccagatt tattgtgcca240cacaaaagga tcatgtgtgt cagcaggggc cgtttggaac aaacctagtc attaatgagt300aagatactcc tgttagttca gggaccaagt tttatgaccc agaggcttaa tgatgtttgg360atatatttca aatcggcgtg cttacctcac tgatttaaat tattttctaa atagtggcca420ttgtagacct gactcaggct gaagctaaat agagaacaat ttagaaagtt aactaacaat480
acagtgcatt ctacccgtag gcccaccatg cccttctgcc cctggctgat ttgatcctgt540gtctgatccc attgcaccct gactgggcag tccctacaga accagtgtta atttgaaggg600cctccactca ggctccaaat gtggcagcca aagagaacaa tccagggaac ctacatttat660ttttaaggac aaatatttcc tcctcagtgg tcctaatgtt cagggcttta gagggaaccc720aggtggtctc ttcaccctgt gtcctagaat gggagagtaa gtagacagtg gtgataaccc780cacactgctt ataagtgcat ctttatagta tttggggctt tcctacccct ttagccttct840gtacctagta ccatattcca gttttaaaga actggcagaa tgtgatggat aacagaggaa900gagctcaatt tatgtttatt ggaagaacat tttacttaaa tgatttgagg ggtgggaggg960agtgaactac tgagtttgcc agagtgaaaa tccatctgaa aaactcagct acctttagtt1020tttagtcctc atttttggtc ttgtctctgc ggactgtgaa gaatcacaat gctctatatg1080ccctggactg tgtggcaaat gcaggttgca gcgtgtgtgt tacatgagga tcttccacaa1140tttcagaatg cacgccagag ctgaaggggg aaacttggta acttgcccat tattctctgc1200ttttagccag agttaaacag actgatgggt ctggtagcca acaacttggc aacttccact1260ccttctcacc tcgtgagatt aagggctgtg aaaagaaatc tagtctaact ccaacagaaa1320tctgtctctg ttaagtgttt taccttctgt aagtagagat ggtagagcca agatttttct1380tttggtaatt tccctgtcta taaagtgaga ccaaagggat atctgttccc tgttaccttt1440ttggagaatt cataacattt gaagatcaaa aaattgaatg ataaatatga atggcttttc1500aattctgtgg actttgtacc atttggcttc accttgtact gcaagatgaa tttgtaaaca1560aaacaaaatt ggactgtctg gaaagctaaa gttctgaaat atggaatgta ctgcctctaa1620tttttctttg tcttcctctc actggcattt ttttctctcc caggtttctt aagaataatg1680ttttttaaag gaggcttttt gcccatcaag aataaaaaga aataaaacca aagggttacc1740ggaaaaaaaa aaaaaaaaaa a 1761
<210>39<211>2414<212>DNA<213>人<400>39ggggtgaggg cagcagctcg ccacagctgc cagccatctg tccattcacc catctgtcca60tctggcagcc cgctgttcag acctgtctgt ctgtccgccc atctctgtaa gcccatctct120gtcccattgt ctatctgacc atctttctct tactgtcctc tttgtctagc tatctggcct180atctgtcgat ccatcttcgt gtctgtcttc agcccccacc tgtttttgtc catctgtcca240attacctgtg actctgtgca tcttcttgtc cattcatctg cccacccatc cgtccctccg300tctgcccacc agccgcccct ctcctcctgg gctgcagagc catggcccgg ggctacgggg360ccacggtcag cctagtcctg ctgggtctgg ggctggcgct ggctgtcatt gtgctggctg420tggtcctctc tcgacaccag gccccatgtg gcccccaggc ctttgcccac gctgctgttg480ccgccgactc caaggtctgc tcggatattg gacgagccat cctccagcag cagggctcac540ccgtggatgc caccatcgcg gctctggtct gcaccagcgt cgtcaaccct cagagcatgg600gcctgggcgg aggggtcatc ttcaccatct acaatgtgac aacagggaag gtggaggtca660tcaatgcccg ggagacggtg ccggccagcc acgccccgag cctgctggac cagtgtgcac720aggctctgcc actgggcaca ggggcccagt ggatcggggt gcccggggag ctccgtggct780atgccgaggc ccaccgccgc catggccgcc tgccctgggc gcagctgttc cagcccacca840tcgcgctgct ccgagggggg catgtggtgg cccctgtcct cagccgtttc ctgcacaaca900gcatcctgcg gccttccttg caggcgtcaa ccctgcgcca gctcttcttc aacgggacag960aacccctgag gcctcaggac ccactcccat ggcctgcact ggccaccacc ctggagaccg1020tggccacaga gggcgtggag gtcttctaca cggggaggct gggccagatg ctggtggagg1080
acattgccaa ggaagggagc cagctgacgc tgcaggacct ggccaagttc cagcccgagg1140tggtggatgc cctggaggtg cccctggggg actataccct gtactcacca ccgccgcctg1200cagggggtgc cattctcagc tttatcctca acgtgctaag agggttcaac ttctcaacag1260agtctatggc caggcctgaa gggagggtga acgtgtacca ccaccttgta gagacgctca1320agtttgccag ggggcagagg tggaggctgg gggaccctcg aagccacccg aagctccaga1380atgcctcccg ggacctgctg ggggagaccc tggcccagct catccgccaa cagatcgatg1440gccgggggga ccaccagctc agccactaca gcttggccga ggcctggggc cacgggacag1500gcacgtccca tgtgtctgtg ctgggggagg atggcagcgc cgtggctgcc accagcacca1560tcaacacacc ctttggagcg atggtgtatt caccacggac aggcatcatc ctcaacaacg1620agctcctgga cttatgcgag cgatgcccct ggggttccgg caccaccccc tcacctgtga1680gtggagacag ggtgggtgga gctcccggaa ggtgctggcc cccagttcca ggcgagcgtt1740ccccatcctc catggtgccc tccatcttga tcaacaaagc ccaggggtcg aagctagtga1800ttggcggggc tggcggggag ctcatcatct ctgctgtggc ccaggccatc atgagcaagc1860tgtggcttgg ctttgacctg agagcggcca ttgcagcccc catcctgcat gtcaacagca1920agggctgtgt ggagtacgag cccaacttca gccaggaggt gcagagggga ctccaagacc1980gtggccagaa ccagacccag aggcccttct tcctgaacgt ggtccaggct gtgtcccagg2040agggggcctg tgtgtacgcc gtctcggacc tgaggaagag tggggaggcc gcaggctact2100aagacactgc tctgcccaga gctgaagtct ggccccacca tgagtcctgt gtccaggccg2160gacatggctg ggggaccaac tactctggca ggatctggac ccctggcagg ggagtccagc2220tgagagtgga agaggtggcg gggaccagct gggcagatga gaggctgagc ctcatcccta2280accccctttc ccagagcccc tggtggtcct gaaccggccc ctctatccct ccgcaggcct2340cttacctggg gccactctcc caccctctcg atctgtatat cctccagtcc aagattaaag2400
aagaggcgga ctgt 2414<210>40<211>2146<212>DNA<213>人<400>40cggggacggt gcgccagtgc cccctccgcg agccccaacc agtagacggt tccctgtctc60ccgcgcccca atttcgattt tcaaacgcaa ctcctacagg attctgagac cccgtcccat120ctcccatatc ccatttccag ctgcaaatta ctgcagaatc tgaacccagg aaagaaaccc180atttgccgac cccctcttcc ctctccagac aggtggagag cgggtgaggg tctcgctcgg240ctttccccct gcacctttcc caccctcccg cccgtccctg ggggtcctcc gtcaccgcgg300ccatggccca gaagccgaag gtggaccccc acgtcgggcg gctgggatac ctgcaggcgc360tggtcacgga attccaggag acccaaagcc aagacgccaa ggagcaagtc ctcgccaacc420tcgccaactt cgcttatgac cccagcaact acgagtatct gcggcagctg caggtcctgg480atttatttct cgattcgctg tcggaggaga atgagaccct ggtggagttt gctattggag540gcctgtgcaa cctgtgccca gacagggcca acaaggagca catcctgcac gcaggaggtg600tcccactcat catcaactgc ctatccagcc ccaatgagga gacggtgctg tctgccatca660ccacgctcat gcacctgagc ccgccgggcc gcagctttct cccagagctg accgccacgc720ccgtggtgca gtgcatgctt cgcttctccc tctcggccag cgccaggctc cggaacctgg780cacagatctt cctggaggac ttctgctccc cccgccaggt ggccgaggcc cgcagccggc840aggcgcactc tgccctgggt atcccactgc cgaggagcgt ggccccacgg cagcgctgat900ccatggagac tgcgagaccg tggcacccct actgctgggg accacagtcc tgatgtggac960gcagggaacg gggagcacat actgccccat tggtgccttt tcagccatct gaaaggcggg1020ttctttcagc aggacaggca tttacactga tgaaacgcca ctgggagtga ggaagccaga1080
ctccagagac acggagaaga tcaaactgga gctgcgttca taggctggca ctctcaatcc1140tacatcaggt gccaccacca ccagactcag gccctggtgt aagaagcggc caagtgcctg1200gacccagagg ctttgcagga cagtgttctc aggagctggg cctgaggctt aggagagctg1260ccttcgctgc aggaaatcag ggattatccc ttaacagaag tgtctggagt agttttcagg1320tataggaatg agatgcctcg tggtgaaagg atctcaccct gggaagatgt ggtgccccct1380ccagggctct ggaggatgga tgcctccccc aggggctctc caagctgggc atttgggcct1440ggtggatgcc aacctggata acctgtggcc cagcattgac tgtccaccca gccttgctgt1500taggcaccat gactccaaga tgaagatgtg gtccctgccc ttgagtgaca gcccagggac1560ttaatgtggc catcgggcat caagcacaag gccatgcagg tgatgatacg tcggaataga1620ggcaccagcc ctggtaactg catcttctcc ccttgccacc ccatggcccc ggctgaaagc1680ttcggccctc ctctgctgtc actcaatgat ggggagccct accccagaag tgtatcccac1740gagggcatca gggacgcagt gagtgttgct caagggagtc aggaagagac ggcaacgtaa1800aggatgtggc tccatgtcca tggtgccccc tggtcaacat aaggagcgtg ggatccgatg1860gaaaggtgga gctcagggaa aatgggggtc cttgcctctc gtgtaccccc tcaaggctga1920ccccttagat ggcccaggaa tggcaggtgc tacaaaaatg gtacccacgt gggcatggaa1980atggggcaga ttaggggacc actggactca gaggggaggg aagggctcat cagcacccgc2040tcagggagcc tgtcccttta tgttcccaaa taaagggtcc tagaagacta gaaagccaag2100gtcttttatt aaaggtcccg actggtaaaa aaaaaaaaaa aaaaaa 2146<210>41<211>8789<212>DNA<213>人<400>41
atgtctgaca aaatgtcgag tttcctacat attggagaca tttgttctct gtacgcggag60ggatcgacaa atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag120ccagaaaccg gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta180tgtcccatga accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc240aacagcacca cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag300aagcagaatg agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg360atccagctcc tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct420ctgttggaga agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg480ttttatattc agccattcta caagctgcga tccattggag acagcgtggt cataggtgac540aaggtggttc tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg600gtagataacc caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata660gtccttttca tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg720aggctgtttc atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag780cacgtcttcc tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc840ctgtgggagg tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac900agccttttcc gtttcaagca tctggccacg gggcattact tggcagcaga ggtggaccct960gatcaggacg cctctcgaag taggttgcgg aatgcccaag aaaagatggt atactccctg1020gtctctgtgc ctgaaggcaa tgacatctcc tccattttcg agctagatcc caccactctg1080cgtggaggtg acagccttgt cccaaggaac tcttatgttc ggctcagaca cctatgtact1140aatacctggg ttcacagcac aaatattcct attgacaagg aagaagaaaa gcccgtgatg1200ctgaaaattg gcacctctcc tgtgaaggag gataaggaag catttgccat agttccggtt1260tctcctgctg aagttcggga cctggacttc gccaatgatg ccagcaaggt gctgggctcc1320
attgctggga agctagagaa gggcaccatc acccagaatg aaaggaggtc tgtaaccaag1380ctgctagaag atttggttta cttcgtcact ggtggaacta attctggtca agatgttctc1440gaagttgtct tctccaagcc caacagagaa cggcagaaac tgatgagaga acagaatatt1500ctcaagcaga tcttcaagtt gttacaagcc ccattcacag actgcggtga tggcccaatg1560cttcggctgg aagagctcgg ggaccagcgg cacgctcctt tcagacacat ctgccggctc1620tgctacaggg tgctgagaca ctcgcagcaa gactacagga agaaccagga gtatatagcc1680aagcagtttg gcttcatgca gaagcagatt ggctatgatg tgttggctga agacactatc1740actgccctgc tccacaataa tcggaaactc ctggaaaaac acattaccgc ggcagagatt1800gacacatttg tcagcctggt gcgaaagaac agggagccca gattcttaga ttacctctcc1860gacctctgtg tctccatgaa caaatcaatt ccagtgaccc aggaactgat atgtaaagct1920gtgctgaacc ccaccaacgc tgacatcctg attgagacca aattggttct ttctcgtttt1980gaatttgaag gtgtctcttc cactggagag aatgctctgg aggcaggaga agacgaggaa2040gaggtgtggc tgttttggag ggacagcaac aaagagattc gcagcaagag tgtgagggaa2100ttggctcagg atgctaaaga agggcagaag gaggaccgag acgttctcag ctactacaga2160tatcagctga acctctttgc gaggatgtgt ctggaccgcc aatacctggc catcaacgaa2220atctcaggcc agctggatgt cgatctcatt ctccgctgca tgtctgacga gaacctgccc2280tatgacctca gggcgtcctt ctgccgcctc atgcttcaca tgcatgtgga ccgagatccc2340caggaacaag tcacccccgt gaaatatgcc cgcctctggt cggagattcc ctcggagatc2400gccattgacg actatgatag tagtggagct tccaaagatg aaattaagga gagatttgct2460cagaccatgg agtttgtgga ggagtattta agagatgtgg tttgtcagag gttccctttc2520tctgataaag agaagaataa gcttacgttt gaggttgtaa atttagctag gaatctcata2580tactttggtt tctacaactt ctctgacctt ctacgattaa ctaagatcct tctggccata2640
ttggactgtg tacatgtgac aacaatcttc cccattagca agatggcgaa aggagaagag2700aataaaggta acaatgatgt ggagaagctg aagagcagta acgtgatgag atctattcat2760ggcgtgggag agctgatgac ccaggtggtg ctccggggag gaggcttttt gcccatgact2820cccatggctg ctgcccctga aggcaatgtg aagcaggcag agcctgagaa ggaggacatc2880atggtcatgg acaccaagct gaagatcatt gagatactcc agtttatttt gaatgtgagg2940ttggattata ggatctcctg cctcctgtgt atatttaagc gagagtttga tgaaagcaat3000tcccagactt cagaaacatc ctccggaaac agcagccaag aagggccaag taatgtacca3060ggtgctcttg actttgaaca cattgaagaa caagcagaag gcatctttgg aggaagtgag3120gagaacaccc cactggactt ggatgaccac ggcggcagaa cctttctccg tgtcctgctc3180cacttgacga tgcatgacta cccacccctg gtgtcagggg ccctgcagct cctcttccgg3240cacttcagcc agaggcagga ggtgctccag gccttcaaac aggttcaact gctggttacc3300agccaagatg tggacaacta caaacagatc aaacaagact tggatcaact gaggtccatc3360gtggaaaagt cagagctttg ggtgtacaaa gggcagggcc ccgatgagac tatggatggt3420gcatctggag aaaatgaaca taagaaaacg gaggagggaa ataacaagcc acaaaagcat3480gaaagcacca gcagctacaa ctacagagtg gtcaaagaga ttttgattcg gcttagcaaa3540ctctgtgttc aagagagtgc ctcagtgaga aagagcagga agcagcaaca gcgtctgctc3600cggaacatgg gcgcgcacgc cgtggtgctg gagctgctgc agattcccta tgagaaggcc3660gaagatacca agatgcaaga gataatgagg ttggctcatg aatttttgca gaatttctgc3720gcaggcaacc agcagaatca agctttgcta cataaacaca taaacctgtt tctcaaccca3780gggatcctgg aggcagtaac catgcagcac atcttcatga acaatttcca gctttgcagt3840gagatcaacg agagagttgt tcagcacttc gttcactgca tagagactca cggtcggaat3900gtccagtata taaagttctt acagacaatt gtcaaggcag aagggaaatt tattaaaaaa3960
tgccaagaca tggttatggc cgagctggtc aattcgggag aggatgtcct cgtgttctac4020aacgacagag cctctttcca gactctgatc cagatgatgc ggtcagaacg ggatcggatg4080gatgagaaca gccctctcat gtaccacatc cacttggtcg agctcctggc tgtgtgcacg4140gagggtaaga atgtctacac agagatcaag tgcaactccc tgctcccgct ggatgacatc4200gttcgcgtgg tgacccacga ggactgcatc cctgaggtta aaattgcata cattaacttc4260ctgaatcact gctatgtgga tacagaggtg gaaatgaagg agatttatac cagcaatcac4320atgtggaaat tgtttgagaa tttccttgta gacatctgca gggcctgtaa caacactagt4380gacaggaaac atgcagactc gattttggag aagtatgtca ccgaaatcgt catgagtatt4440gttactactt tcttcagctc tcccttctca gaccagagta cgactttgca gactcgccag4500cctgtctttg tgcaactgct gcaaggcgtg ttcagggttt accactgcaa ctggttaatg4560ccaagccaaa aagcctccgt ggagagctgt attcgggtgc tgtctgatgt agccaagagc4620cgggccattg ccattcccgt ggacctggac agccaagtca acaacctctt tctcaagtcc4680cacagcattg tgcagaaaac agccatgaac tggcggctct cagcccgcaa tgccgcacgc4740agggactctg ttctggcagc ttccagagac taccggaata tcattgagag attgcaggac4800atcgtctccg cgctggagga ccgtctcagg cccctggtgc aggcagagtt atctgtgctc4860gtggatgttc tccacagacc cgagctgctt ttcccagaga acacagacgc cagaaggaaa4920tgtgaaagtg gcggtttcat ttgcaagtta ataaagcata caaaacagct gctagaagaa4980aatgaagaga agctctgcat taaggtccta cagaccctga gggaaatgat gaccaaagat5040agaggctatg gagaaaagct aatttccatt gatgaattgg ataatgctga gcttcctcca5100gctccggatt ctgagaacgc cactgaggag cttgaaccaa gtccacccct gcggcagctg5160gaagaccata aaaggggtga ggcgctcagg caagttctgg tcaaccgtta ctatggaaac5220gtcagacctt cgggacgaag agagagcctt accagctttg gcaatggccc actgtcagca5280
ggaggacccg gcaagcccgg gggaggaggg ggaggttccg gatccagctc tatgagcagg5340ggtgagatga gtctggccga ggttcagtgt caccttgaca aggagggggc ttccaatcta5400gttatcgacc tcatcatgaa cgcatccagt gaccgagtgt tccatgaaag cattctcctg5460gccattgccc ttctggaagg aggcaacacc accatccagc actccttttt ctgtcgcttg5520acagaagata agaagtcaga gaaattcttt aaggtgtttt atgaccggat gaaggtggcc5580cagcaagaaa tcaaagcaac agtgacagtg aacaccagtg acttgggaaa taaaaagaaa5640gacgatgagg tagacaggga tgccccatca cggaaaaaag ctaaagagcc cacaacacag5700ataacagaag aggtccggga tcagctcctg gaggcctccg ctgccaccag gaaagccttc5760accactttca ggagggaggc tgatcccgac gaccactacc agcctggaga gggcacccag5820gccactgccg acaaggccaa ggacgacctg gagatgagcg cggtcatcac catcatgcag5880cccatcctcc gcttccttca gctcctgtgt gaaaaccaca accgagacct gcagaacttc5940ctccgttgcc aaaataacaa gaccaactac aatttggtat gtgagaccct gcagtttctg6000gactgtattt gtggaagcac aactggaggc cttggtcttc tgggcttgta tataaatgaa6060aagaacgtag cgcttatcaa ccaaaccctg gaaagtctga ccgaatactg tcaaggacct6120tgccatgaga accagaactg catagccacc catgaatcca atggcattga catcatcaca6180gccctgatcc tcaatgatat caatcctttg ggaaagaaga ggatggacct tgtgttagaa6240ctgaagaaca atgcctcgaa gttgctcctg gccatcatgg aaagcaggca cgacagtgaa6300aacgcagaga ggatacttta taacatgagg cccaaggaac tggtggaagt gatcaagaaa6360gcctacatgc aaggtgaagt ggaatttgag gatggagaaa acggtgagga tggggcggcg6420tcccccagga acgtggggca caacatctac atattagccc atcagttggc tcggcataac6480aaagaacttc agagcatgct gaaacctggt ggccaagtgg acggagatga agccctggag6540ttttatgcca agcacacggc gcagatagag attgtcagat tagaccgaac aatggaacag6600
atagtctttc ccgtgcccag catatgtgaa ttcctaacca aggagtcaaa actacgaatt6660tactatacta cggagagaga cgaacaaggc agcaaaatca atgatttctt tctgcggtct6720gaagacctct tcaatgaaat gaattggcag aagaaactga gagcccagcc cgtgttgtac6780tggtgtgccc gcaacatgtc tttctggagc agcatttcgt ttaacctggc cgtcctgatg6840aacctgctgg tggcgttttt ctacccgttt aagggagtcc gaggaggaac cctggagccc6900cactggtcgg gactcctgtg gacagccatg ctcatctctc tggccatcgt cattgccctc6960cccaagcccc atggcatccg ggccttaatt gcctccacaa ttctacgatt gatattttca7020gtcgggttac aacccacgtt gtttcttctg ggcgctttca atgtatgcaa taaaatcatc7080tttctaatga gctttgtggg caactgtggg acattcacaa gaggctaccg agccatggtt7140ctggatgttg agttcctcta tcacttgttg tatctggtga tctgtgccat ggggctcttt7200gtccatgaat tcttctacag tctgctgctt tttgatttag tgtacagaga agagactttg7260cttaatgtca ttaaaagtgt cactcgcaat ggacgggcca tcatcctgac agcagttctg7320gctctgatcc tcgtttacct gttctcaata gtgggctatc ttttcttcaa ggatgacttt7380atcttggaag tagataggct gcccaatgaa acagctgttc cagaaaccgg cgagagtttg7440gcaagcgagt tcctgttctc cgatgtgtgt agggtggaga gtggggagaa ctgctcctct7500cctgcaccca gagaagagct ggtccctgca gaagagacgg aacaggataa agagcacaca7560tgtgagacgc tgctgatgtg cattgtcact gtgctgagtc acgggctgcg gagcgggggt7620ggagtaggag atgtactcag gaagccgtcc aaagaggaac ccctgtttgc tgctagagtt7680atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg7740gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg7800aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc7860tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg7920
gtgaaagtaa aggactccac cgaatatact gggcctgaga gttacgtggc agaaatgatc7980aaggaaagaa accttgactg gttccccagg atgagagcca tgtcattggt cagcagtgat8040tctgaaggag aacagaatga gctgagaaac ctgcaggaga agctggagtc caccatgaaa8100cttgtcacga acctttctgg ccagctgtcg gaattaaagg atcagatgac agaacaaagg8160aagcagaaac aaagaattgg tcttctagga catcctcctc acatgaatgt caacccacaa8220caaccagcat aagcaaatga aagaaaggaa ttgtatttac cttttataat tattattagt8280gtgggaatgg ctaatgagtt ctgattcacc cacgaaggtt acatttatgc tgaatacatt8340tgtaaatact cagttttata ctgtatgtat atgattgcta ctctaaaggt ttggatatat8400gtattgtaat tagaattgtt ggcatgatga catttcattt gtgccaaaaa tattaaaaat8460gccttttttg gaaggactaa cagaaagcac ctgatttgca cttgaaccag attatagatt8520taaaagtata tgacatgtat tttgtattta aaactagaat agccagtatt tatgtttttt8580ataaaactgt gcaatacgaa ttatgcaatc acaatacatt tgtagctccc gagtgtccta8640aagggagtgc acttctttga agctggtgtg ttaatactat gtaataaatg gttaactttc8700aaatgatgct gctgccaaaa ttatattaat agagagtttc aggcccctgg gaattcctgc8760agcccggggg atccccgggt accgagctc 8789<210>42<211>4394<212>DNA<213>人<400>42aaactcccag ggcccgccca ggacccccaa gccgccgcgg acgcagccca ggatggcggc60ccaggtgact ctggaggacg cgctgtccaa cgtggacctc ctggaggagc tgcccctgcc120cgaccagcag ccctgcatcg agcccccgcc atcctcgctg ctctaccagc caaatttcaa180cactaacttt gaagacagaa atgcatttgt tactggcatc gcaagataca ttgaacaagc240
caccgtccac tctagcatga acgagatgct ggaggagggc caagaatatg ctgtcatgct300gtacacctgg aggagctgct cccgggccat cccacaggtg aaatgtaacg agcagcctaa360cagagtggaa atctacgaga aaaccgtgga ggttctggag cctgaggtca caaaactgat420gaatttcatg tacttccaga gaaatgccat tgagcgtttc tgcggggaag tgaggcgcct480gtgccatgcc gagaggagga aggacttcgt gtcagaagcc tacctgatca cactgggcaa540attcatcaac atgttcgctg tgctggacga gctgaagaac atgaagtgca gtgtgaagaa600cgaccactca gcgtacaaga gggccgctca gtttttacgt aaaatggcag atccacagtc660catccaggaa tcgcagaatc tgtccatgtt cctggccaat cataacaaga tcacacagtc720tctgcagcag cagctcgaag tgatttctgg ctacgaagag ctcctggcag atattgtgaa780tctgtgtgtg gattactacg agaacaggat gtatttgacg cccagtgaga aacacatgct840tctcaaagtc atgggatttg gtctgtacct gatggatggg agtgtcagta acatctataa900gttggatgcc aagaaaagaa taaacttatc caaaatcgac aagtacttca agcaactcca960ggtggttcca ctatttgggg acatgcaaat agaactggca agatatatca agaccagcgc1020ccactacgag gaaaataaat ctcgatggac gtgcacatcc tccggcagca gccctcagta1080caacatctgc gagcagatga tccagatccg cgaggaccac atgcgcttca tttcggagct1140ggcgcgctac agcaacagcg aggtggtcac gggctcgggc cgccaggagg cccagaagac1200ggacgcggag taccgcaagc tcttcgacct ggcgctgcag ggcctgcagc tgttgtcgca1260gtggagcgcg cacgtgatgg aagtgtattc ctggaagctt gtgcacccca ccgacaagta1320ctccaacaag gactgccccg acagcgctga agagtacgag cgtgccacgc gctacaacta1380caccagcgag gagaagtttg ccctagtgga ggtgatcgcc atgatcaaag gcctgcaggt1440gctgatgggc aggatggaga gcgtgttcaa ccacgccatc cggcacaccg tctatgccgc1500actgcaggac ttctcccagg tgacccttag ggagccgctg cggcaggcca tcaagaagaa1560
gaagaacgtc atccagagtg tcctgcaggc catcaggaag accgtgtgtg actgggagac1620ggggcatgag cccttcaatg acccagcctt gcggggcgag aaggacccca agagcggctt1680cgacataaaa gtaccacgcc gcgccgtggg accctccagc actcagcttt acatggtgag1740aaccatgcta gagtccctca ttgcagacaa aagtggttcc aagaaaacct tgagaagtag1800ccttgagggg cccaccatat tggacataga aaaatttcat cgagagtcat tcttctacac1860tcacttgata aatttcagtg aaacgctgca gcagtgctgt gacctttcgc agctgtggtt1920ccgagagttc ttcctggagc tgaccatggg caggaggatc cagttcccca ttgagatgtc1980gatgccctgg atcctgacgg accacatcct ggagaccaag gaggcatcga tgatggagta2040cgtgctctac tccctggacc tgtacaatga cagcgcccac tacgcgctca ccaggttcaa2100caagcagttc ctgtacgacg aaattgaggc cgaggtgaat ctatgttttg accaatttgt2160ttacaagcta gcagaccaga tatttgccta ttataaggtt atggcaggaa gtttgcttct2220tgataaacgg ttacgatcag aatgcaagaa tcagggagcc acgatccacc tcccgccgtc2280taaccgctac gagacgctgc tgaagcagag gcatgtgcag ctcctcggca gatcaataga2340cctcaatcgt ctgatcaccc agcgcgtctc agcagccatg tataagtccc tagaactggc2400gattggacga tttgaaagtg aagatttgac ctccatagtt gagctggatg gcctgttgga2460aatcaaccgc atgacccaca agctgctgag ccggtacctg acgctggacg gcttcgacgc2520catgttccgg gaggccaacc acaacgtgtc agcgccctac gggaggatca ccctgcacgt2580cttctgggag ctcaactatg acttcctgcc caactactgc tacaacggct ctaccaaccg2640gtttgttcgg acagtgttac cattttctca ggaatttcaa agagataagc agcctaatgc2700acagcctcag tatctgcatg gatccaaggc tttgaacttg gcctactcca gcatttacgg2760cagctaccgg aacttcgtgg gacctccaca ctttcaagtc atctgccggc ttctcggcta2820ccagggtatc gccgtggtca tggaggagct gctgaaggtc gtcaagagcc tgctgcaagg2880
cacaatcctg cagtacgtga agacgctgat ggaggtgatg cccaagatct gccgcctgcc2940ccggcacgag tacggctctc ctggtatcct ggagttcttc caccaccagc tgaaggacat3000cgtggagtac gcagagctga agacggtgtg cttccagaac ctgcgggagg tggggaacgc3060catcctcttc tgcctgctca tcgagcagag cctgtcttta gaagaagtgt gtgacctgct3120gcacgcggct cctttccaga acatcttgcc gcgagtccat gtgaaagagg gggagagact3180tgatgccaaa atgaaaagac tagaatcaaa gtacgccccg ctgcatcttg tcccactgat3240tgaaagactg gggacccctc agcaaattgc catcgcaaga gagggggacc tgctgacaaa3300ggagcgcctc tgctgcggcc tgtccatgtt tgaggtcatc ctgacacgga tccggagctt3360tctggatgac cccatctggc gcgggcctct gcccagcaat ggggtcatgc atgtggacga3420gtgtgtggag tttcacagac tgtggagtgc catgcagttt gtctactgca ttcccgtggg3480gacacacgag ttcacagtcg agcagtgctt tggtgatggg ctacactggg ctggctgtat3540gatcatcgta cttcttgggc agcagcggcg ttttgctgtg ctggatttct gctaccatct3600acttaaagtc cagaaacatg atggcaaaga tgagattatt aaaaatgtgc ctttgaagaa3660gatggtggag agaattcgca agttccagat tctcaatgat gagatcatca ccatcctgga3720taagtacctg aagtcaggcg acggggaggg cacgccagtg gagcatgtgc gctgcttcca3780gccgcccatc caccagtccc tcgccagcag ctgagggcac gcgctgcact ccgtaactca3840acatggcatg cctttctctc cgtaaactat ttagtgagat ttttagggac tatttttcag3900tatctctgta cctgttaaag ggggtgcttt tcgatctaaa aacttaattt tataaaattg3960acttattttt ctagactaaa attgtatatg cttttggtaa ttaggaactc ttgagaatat4020tggctgctga ttgttgccat cacgttccta caaaattgtt tttctatggg atgttctggc4080agctgtgtca taaaatgctg ctgggttcat tcattcattc cataagaaac ttaataccag4140caaatgcatt aaatcccttg ccagttacca ttaactataa ctatttagct tttgtttagg4200
gatctttctg atggtctttt atgagcaatc ttagttctaa gtcattgttc ccatcccttt4260tttgtgtgtt tcagaaaata gtgaacttga ttcccctgct tccactaaat ccagttgtga4320caaaatctaa cgtgacatca gatcgaaagg ttatagaaat aaaactaatg agatctaaaa4380aaaaaaaaaa aaaa 4394<210>43<211>1166<212>DNA<213>人<400>43gcaagaatgg tgcctgtcct gctgtctctg ctgctgcttc tgggtcctgc tgtcccccag60gagaaccaag atggtcgtta ctctctgacc tatatctaca ctgggctgtc caagcatgtt120gaagacgtcc ccgcgtttca ggcccttggc tcactcaatg acctccagtt ctttagatac180aacagtaaag acaggaagtc tcagcccatg ggactctgga gacaggtgga aggaatggag240gattggaagc aggacagcca acttcagaag gccagggagg acatctttat ggagaccctg300aaagacattg tggagtatta caacgacagt aacgggtctc acgtattgca gggaaggttt360ggttgtgaga tcgagaataa cagaagcagc ggagcattct ggaaatatta ctatgatgga420aaggactaca ttgaattcaa caaagaaatc ccagcctggg tccccttcga cccagtagcc480cagataacca agcagaagtg ggaggcagaa ccagtctacg tgcagcgggc caaggcttac540ctggaggagg agtgccctgc gactctgcgg aaatacctga aatacagcaa aaatatcctg600gaccggcaag atcctccctc tgtggtggtc accagccacc aggccccagg agaaaagaag660aaactgaagt gcctggccta cgacttctac ccagggaaaa ttgatgtgca ctggactcgg720gccggcgagg tgcaggagcc tgagttacgg ggagatgttc ttcacaatgg aaatggcact780taccagtcct gggtggtggt ggcagtgccc ccgcaggaca cagcccccta ctcctgccac840
gtgcagcaca gcagcctggc ccagcccctc gtggtgccct gggaggccag ctaggaagca900agggttggag gcaatgtggg atcttagacc cagtagctgc ccttcctgcc tgatgtggga960gctgaaccac agaaatcaca gtcaatggat ccacaaggcc tgaggagcag tgtgggggga1020cagacaggag gtggatttgg agaccgaaga ctgggatgcc tgtcttgagt agacttggac1080ccaaaaaatc atctcacctt gagcccaccc ccaccccatt gtctaatctg tagaagctaa1140taaataatca tccctccttg cctagc 1166<210>44<211>5221<212>DNA<213>人<400>44cggccgcccg ggcaggtttt gtagactttc atagccaaag aaaccggctt cggcttcttt60aaaatccccg acgactcacc tgattaacct gctgcagttc tgaccctgcc aagagctgac120aatttactgg ttcatcaatg aaacaatatt aaattatgaa gatgtaagga aaaaatccta180cgctaacact gtcgcagttt gaaaggcttc tctgcagaat gtcaaacaaa gatcgacaca240ttgattccag ctgttcgtcc ttcatcaaga cggaaccttc cagcccagcc tccctgacgg300acagcgtcaa ccaccacagc cctggtggct cttcagacgc cagtgggagc tacagttcaa360ccatgaatgg ccatcagaac ggacttgact cgccacctct ctacccttct gctcctatcc420tgggaggtag tgggcctgtc aggaaactgt atgatgactg ctccagcacc attgttgaag480atccccagac caagtgtgaa tacatgctca actcgatgcc caagagactg tgtttagtgt540gtggtgacat cgcttctggg taccactatg gggtagcatc atgtgaagcc tgcaaggcat600ctttcaagag gaaaatacaa gccaatatag aatacagctg ccctgccacg aatgaatgtg660aaatcacaaa gcgcagacgt aaatcctgcc aggcttgccg cttcatgaag tgtttaaaag720tgggcatgct gaaagaaggg gtgcgtcttg acagagtacg tggaggtcgg cagaagtaca780
agcgcaggat agatgcggag aacagcccat acctgaaccc tcagctggtt cagccagcca840aaaagccata taacaagatt gtctcacatt tgttggtggc tgaaccggag aagatctatg900ccatgcctga ccctactgtc cccgacagtg acatcaaagc cctcactaca ctgtgtgact960gtgccgaccg agagttggtg gttatcattg gatgggcgaa gcatatccca ggcttctcca1020cgctgtccct ggcggaccag atgagccttc tgcagagtgc ttggatggaa attttgatcc1080ttggtttcgt ataccggtct ctttcgtttg aggatgaact tgtctatgca gacgattata1140taatggacga agaccagtcc aaattagcag gccttcttga tctaaataat gctatcctgc1200agctggtaaa gaaatacaag agcatgaagc tggaaaaaga agaatttgtc accctcaaag1260ctatagctct tgctaattca gactccatgc acatagaaga tgttgaagcc gttcagaagc1320ttcaggatgt cttacatgaa gcgctgcagg attatgaagc tggccagcac atggaagacc1380ctcgtcgagc tggcaagatg ctgatgacac tgccactcct gaggcagacc tctaccaagg1440ccgtgcagca tttctacaac atcaaactag aaggcaaagt cccaatgcac aaactttttt1500tggaaatgtt ggaggccaag gtctgctaaa agctccctgg gccttccatc cttcattgtt1560gaaaagggga aataaaccca agagtgatgt cgaagaaact tagagtttag ttaacaacat1620caaaaatcaa cagactgcac tgataattta gcagcaagac tatgaagcag ctttcagatt1680cctccatagg ttcctgatga gtttctttct actttctcca tcatcttctt tcctctttct1740tcccacattt ctctttctct ttatttttta tccttttctt ctttcacctc ccttatttct1800ttgcttcttt cattcctagt tcccattctc ctttattttc ttcccgtctg cctgccttct1860ttcttttctt tacctactct cattcctctc ttttctcatc cttccccttt tttctaaatt1920tgaaatagct ttagtttaaa aaaaaatcct cccttccccc tttcctttcc ctttctttcc1980tttttccctg tccttttccc tttcctttcc tttcctcttg accttctttc catctttctt2040tttcttcctt ctgctgctga acttttaaaa gaggtctcta actgaagaga gatggaagcc2100
agccctgcca aaggatggag atccataata tggatgccag tgaacttatt gtgaaccata2160ccgtccccaa tgactaagga atcaaagaga gagaaccaac gttcctaaaa gtacagtgca2220catatacaaa ttgactgagt gcagtattag atttcatggg agcagcctct aattagacaa2280cttaagcaac gttgcatcgg ctgcttctta tcattgcttt tccatctaga gcagttacag2340ccatttgatc ccttaattgt tttttcaagt ctcccaggta tttgttagtt tagctactat2400gtaacttttt cagggaatag tttaagcttt attcagtcat gcaatactaa agagaaataa2460gaatactgca attttgtgct ggctttgaac aattacgaac aataatgaag gacaaatgaa2520tcctgaagga agatttttaa aaatgttttg tttcttctta caaatggaga tttttttgta2580ccagctttac cacttttcag ccatttatta atatgggaat ttaacttact caagcaatag2640ttgaagggaa ggtgcatatt atcacggttg caatttatgg ttgtgtgccc agtctggtcc2700ccaaacatca atttcttaac atgagctcca gtttacctaa atgttcactg acacaaagga2760tgagattaca cctacagtga ctctgagtag tcacatatat aagcactgca catgagatat2820agatccgtag aattgtcagg agtgcacctc tctacttggg aggtacaatt gccatatgat2880ttctagctgc catggtggtt aggaatgtga tacatgcctg tttgcaaagt cacagaccat2940tgcctcagaa ggagctgtga gccagtattc atttaagagg caataaggca aatgccagaa3000ttaaaaaaaa aaaatcatca aagacagaaa atgcctgacc aaattctaaa acctaatcca3060tataagttta ttcatttagg aatgttcgtt taaattaatc tgcagttttt accaagagct3120aagccaatat atgtgctttt caaccagtat tgtcacagca tgaaagtcac agtcaggttc3180cagactgtta agaggtgtaa tctaatgaag aaatcaatta gatgccccga aatctacagt3240cgctgaataa ccaataaaca gtaacctcca tcaaatgcta taccaatgga ccagtgttag3300tagctgctcc ctgtattatg tgaacagtct tattctatgt acacagatgt aattaaaatt3360gtaatcctaa caaacaaaag aaatgtagtt cagcttttca atgtttcatg tttgctgtgc3420
ttttctgaat tttatgttgc attcaaagac tgttgtcttg ttcttgtggt gtttggattc3480ttgtggtgtg tgcttttaga cacagggtag aattagagac aatattggat gtacaattcc3540tcaggagact acagtagtat attctattcc ttaccagtaa taaggttctt cctaataata3600attaagagat tgagactcca aacaagtatt cattatgaac agatacacat caaaatcata3660ataatatttt cagaacaagg aataatttct ctaatggttt attatagaat accaatgtat3720agcttagaaa taaaactttg aatatttcaa gaatatagat aagtctaatt tttaaatgct3780gtatatatgg ctttcactca atcatctctc agatgttgtt attaactcgc tctgtgttgt3840tgcaaaactt tttggtgcag attcgtttcc aaaactattg ctactttgtg tgctttaaac3900aaaatacctt gggttgatga aacatcaacc cagtgctagg aatactgtgt atctatcatt3960agctatatgg gactatattg tagattgtgg tttctcagta gagaagtgac tgtagtgtga4020ttcttgataa atcatcatta gcaattcatt cagatggtca ataacttgaa atttatagct4080gtgataggag ttcagaaatt ggcacatccc tttaaaaata acaacagaaa atacaactcc4140tgggaaaaaa aggtgctgat tctataagat tatttatata tgtgagtgtt taaaaagatt4200attttccaga aagtttgtgc agggtttaag ttgctactat tcaactacac tatatataaa4260taagatatat acaatatata cattgttttc actgtatcac attaaagtac ttgggcttca4320gaagtaagaa gccaaccaac tgaaaacctg agatggagat atgttcaaag aatgagatac4380aattttttag ttttcagttt aagtaactct cagcattaca aaagagtaag tatctcacaa4440ataggaaata aaactaaaac gtagatttaa aaaagaactg cacgggcttt agggtaaatg4500ctcatcttaa acctcactag agggaagtct tctcaagttt caagcaagac catttactta4560atgtgaagtt ttggaaagtt ataaaggtgt atgttttagc catatgatcc taaatttaat4620tttgctcttt taggttcgtt cttatttaaa gcaatatgat tgtgtgactc cttgtagtta4680cacttgtgtt tcaatcagat cagattgttg tatttattcc actattttgc atttaaatga4740
tagcataaca gatataaaaa atttaaaact gctatttttc ttatagaaga gaaaatgggt4800gttggtgatt gtattttaat tatttaagcg tctctgttta cctgcctagg aaagcatttt4860atggcagtct tatgtgcaaa gatcgtaaaa ggacaaaaaa tttaaactgc ttataataat4920ccaggagttg cattatagcc agtagtaaaa aaaataataa taataataat aaaaccatgt4980ctatagctgt agatgggctt cacatctgta aagcaatcaa ttgtatattt ttgtgatgtg5040taccatactg tgtgctccag caaatgtcca tttgtgtaaa tgtatttatt ttatattgta5100tatattgtta aatgcaasaa ggagatatga ttctgtaact ccaatcagtt cagatgtgta5160acccaaatat tatgcctttc aggatgatgg tagagcaata ttaaacaagc ttccactttt5220g5221<210> 45<21l>1174<212>DNA<213>人<400>45ggcacgaggg ggccggagga gggacgcgcc ggagcgggac cgacgggacc gagcgagcga60ccgacgcgcc acccgccgac gcetcagccg cttggggccc gcacggacce tctacttcag120tgtagaatga gccaaggaga ctcaaaccca gcagetattc cgcatgcagc agaagatatt180caaggagatg acegatggat gtctcagcac aacagatttg ttttggactg taaagacaaa240gagcctgatg tactgttcgt gggagactcc atggtgcagt taatgcagca atatgagata300tggcgagagc ttttttcccc acttcatgca ctgaattttg gaattggggg agaracaaca360agacatgttt tgtggagact aaagaatgga gaactggaga atattaagcc taaggtcatt420gttgtctggg taggaacaaa taaccaogaa aatacagcag aagaagtagc aggtgggatc480gaggccattg tacaacttat caacacaagg cagccacagg ccaaaatcat tgtattgggt540
ttgttacctc gaggtgagaa acccaatcct ttgaggcaaa agaacgccaa ggtgaaccaa600ctcctcaagg tttcgctgcc gaagcttgcc aacgtgcagc tcctggatac cgacgggggt660tttgtgcact cggacggtgc catctcctgc cacgacatgt ttgattttct gcatctgaca720ggagggggct atgcaaagat ctgcaaaccc ctgcatgaac tgatcatgca gttgttggag780gaaacacctg aggagaaaca aaccaccatt gcctgactgg ctcttatcag tgttaatagc840atctcagctt cctcagatca gttctatcac tggcactaca gaatccttct ctttcttaag900gcactttgca ttgtagaatg ttcctggatg ttcatatcta gtgtttgaag gggaggaggg960atttaaactg gtcctgtaca tagaaggttt gtttgacaga ggagaaaaat tagccaagga1020agattgttgt ttaaattcat ttgaaaccag aaggggactt tttagttgta tgtgtaacac1080attcattgaa ttattatcac tgttttcttg ggacaacatc aagcctaaat actgaacaat1140atgaagatta aaaaaaaaaa aaaaaaaaaa aaaa1174<210>46<211>1619<212>DNA<213>人<400>46ggggatatgg cggggccttt gtctctcgct gtcgccggag tcctaggtct gtcttcactg60ctctgtgtcc tctgctccta gaggcccagc ctctgtggcg ctgttaccag cagtattgga120gatccacagc taagatgcca ggacccccta gaagcctaga aatgggactg ttgacattta180gggatgtggc catagaattc tctctggagg agtggcaaca cctggacatt gcacagcaga240atttatatag aaatgtgatg ttagagaact acagaaacct ggccttcctg ggtattgctg300tctctaagcc agacctgatc acctgtctgg aacaagggaa agagccctgg aatatgaagc360gacatgagat ggtggatgaa cccccaggta tgtgtcctca ttttgctcaa gacctttggc420cagagcaggg catggaagat tcttttcaaa aagcaatact gagaagatat ggaaaatatg480
gacatgagaa tttacagtta agaaaaggct gtaaaagtgt ggatgagtat aaggtgaaca540aagaaggtta taatggactt aaccagtgtt tcacaactgc ccagagcaaa gtatttcaat600gtgataaata tttgaaagtc ttctataaat ttttaaattc aaacagacct aagataagac660atactgaaaa gaaatctttc aaatgtaaaa aacgtgtcaa attattttgc atgctttcac720ataaaaccca acacaaaagc atttatcata gagagaagtc ctacaaatgt aaagaatgtg780gaaaaacctt taattggtcc tcaaccctta ctaatcatag gaaaatttat actgaagaga840aaccttacaa atgtgaagaa tataacaaat ctcctaagca actctcaacc cttactacac900atgaaataat tcatgctgga gagaaactct acaaatgtga agaatgtggc aaagctttta960atcggtcctc aacttttact aaacataagg taattcatac tggagtaaaa ccctacaaat1020gtgaagaatg tggcaaagca tttttctggt cctcaaccct aactaaacat aagagaattc1080atactggaga gcaaccctac aaatgggaaa aatttggcaa agcctttaat cggtcctcgc1140acctcaccac agataagata actcatactg gagagaaatc ttacaagtat gaataatgtg1200ccaaagccta agaaaaccct caattcttaa tagatataag attattccta ctggagagaa1260actacaaacc tgagagaggc gctaatgctt ttgacagtac ctaaaacttt aaagaaaatc1320attctgctga aaaatcctag aaatgtgaag aatgtgaaaa agcctttaaa tgattgtcac1380acttgattgt aggtaagata attcatactg gagaaaacta ccagtgtgaa caacgtggcc1440aagcttcgac aatgctcaca ccctattgca caggaaagca tttatacttg agaagaaatg1500tacaaatatt ggcaaagtaa aaaatccatt aacacctgct cacatcttac tcaaaattgt1560agagttcata gtaaataaaa gcattaaaat tcaaaaaaaa aaaaaaaaaa aaaaaaaaa 1619<210>47<211>534<212>DNA<213>人
<400>47tttttacaac atatatcttt aattaaattt atattggtgg gtttaaaaaa cattaagtca60ggagatgata gctagggaaa taaggtatcc tgtgagtatt tataacaaaa tatttaaaat120ttaaaaagaa taagaaacat caattggctt tttgtaactt aaaagagact aaccaagtgt180tgtttcccag ttctgtacaa gcagaggcca caggaggatt cttacataag aagcacaggg240aaaagaattg ttaattctgc gtgtgtgttt ttgtttctca gaattgtttg gaagaacttt300gtccagtcag aaatgagtaa aaacaagatg taagaaacat taaaacaggg ggcatatggt360cttaagagat aatcttggag aatatagcaa aagacaaatt gctccattag atattataat420ttggtatgta acatgaacat ttaaaattct gattaaagtg actaaaaggg tttgtttttt480aaaaaaaatc aaaacagaac ttacgggata aaactcagaa taaatttact ctca 534<210>48<211>4763<212>DNA<213>人<220>
<221>混杂的特征<222>(3847)..(3847)<223>任何一种碱基<400>48cccctcaccc cactcaactg ccccgggccc ccgcgcgcgc ggccgcccct ccactcaccc60tgtgtcggcc ccgctcccct ctcccccacc aggcgagcag gcgagcgggc agagcccgcg120gcggaggtcg gcgcggctcc ggggttcatg gtgacgaggc ggcggccgct cgagcccagc180ggcggcgggc ggcgggagct ggggcgcggg cccgggccgc ctctcccaga gcgcggggcc240gggcggcggg cgcgcccagg cagcggctgc gagcgccccc ccgcgccgcg cccccgcgcc300ccccgcgccg cgcccccgcg cgcttggctt gcggggggcc gggcctgcgg gcggccgccg360
cgccgcgcac ccatggacgg cccggccatc atcacccagg tgaccaaccc caaggaggac420gagggccggt tgccgggcgc gggcgagaaa gcctcccagt gcaacgtcag cttaaagaag480cagaggagcc gcagcatcct tagctccttc ttctgctgct tccgtgatta caatgtggag540gcccctccac ccagcagccc cagtgtgctt ccgccactgg tggaggagaa tggtgggctt600cagaagccac cagctaagta ccttcttcca gaggtgacgg tgcttgacta tggaaagaaa660tgtgtggtca ttgatttaga tgaaacattg gtgcacagtt cgtttaagcc tattagtaat720gctgatttta ttgttccggt tgaaatcgat ggaactatac atcaggtgta tgtgctgaag780cggccacatg tggacgagtt cctccagagg atggggcagc tttttgaatg tgtgctcttt840actgccagct tggccaagta tgcagaccct gtggctgacc tcctagaccg ctggggtgtg900ttccgggccc ggctcttcag agaatcatgt gtttttcatc gtgggaacta cgtgaaggac960ctgagtcgcc ttgggcggga gctgagcaaa gtgatcattg ttgacaattc ccctgcctca1020tacatcttcc atcctgagaa tgcagtgcct gtgcagtcct ggttcgatga catgacggac1080acggagctgc tggacctcat ccccttcttt gagggcctga gccgggagga cgacgtgtac1140agcatgctgc acagactctg caataggtag ccctggcctc tgcctgcctc ccgcctgtgc1200actctggaac ctctggcctc aggggacctg cctgtcctca gctccctggg agctgaaagt1260gaggatactc cgtgctccag gccacagggt gaatgtggcc atgcctacct gttttgtttt1320tttaagaaca gaaacaacta ttttaaaaga actcttttaa gaaatttcat aaagggacat1380gcattttact gggtttgctt ttcttaaaac ataccaaaaa agaaaaaaat agaaaaaaaa1440aaaaaaaaag ctgatctcta tcagactctt caactgtcct ccctccaagc agaccacctg1500tccccttcta tcccagctca gagcagctga cccaactcag aatctctttc ctacaggatg1560aaagtgcctt ttgaatgtta tttttaagcc gagagttaat ttttctacac aacatatttc1620cagacatctt ttagtctttt attgtcttag atactataag aagatgaaca tgacaatttt1680
ctagaacctg gtagcgtgtg tgtgtggttg gcggggggtg ctgagggagg ggagtgagtc1740acaggagcct gtcccccaac aggtgtgact gctctgacaa cctgtggcat gctgcagggt1800caggctcctg ataggaggat ttcatgacta tgtcattgtc tccactcatt tttgacccag1860tttggaatgt atctgcaatt gtgtggctca acactttagg aaacatagat tattttatat1920tattatttct gatggtgaca agtttgtctt gaggtcacat tttctccttg aaaagtgaca1980tcctgtcact tctgctctca cactactgcc atacatttgt gtttttttgt tgttattgtt2040tgggtagagc agttacaaga aaccctaaaa cccttggata taaaagaaat ctgtttattg2100atttttaaat ctttcctttc caaaagctgg atacacatgg agctgtttgg gaattttcct2160tgctgctacc gcgctgccac caaatggaat tgaccagcgg ctgttacact gttctttgcc2220actgtgccta tgctcagaat atgctcactg ctaagctaca aactcggaca gggtcagaaa2280cagaggtgtc ccatcccatt gcagcctcca ccacctgtaa ccccttcctg gcattggcca2340ctgaagggta caaaggcaaa aggaccacag caccacttag gtgtagcatg gattttaaac2400tgcagtcagt atcagatcct gtttgataaa taagctgact gttctctctt gagaacctgt2460ggcctcaacc agccaccaag ctgatgtggc ccaagctcca tctcttggtc ttctcctttg2520aagcacagcc tatttctgag ccaagggttg gggaagcctg tctagatgtg ggactcattg2580ccccaaacca gggagaggaa gagctcccac agggagagcc caggctctct ttgcagcctt2640tcccagtttg gtgtttaaag cagtgccatg ttccttgttt gacaacaaga cagtctgtaa2700agtattgctc ttaaaaacaa ttaaaaagaa ccctttcata ttggcaccat tgccttagtc2760ctctgtgggt tggtcttcag ccagcattct ggtgggagtg actggcatta acaagactgg2820aaatcggggg tcaaagtaaa atatctttgt tttgctttca ttcacaaagt aatgaagcca2880gctgccaatt acatcctccc aacagcactt tggtctgtga ctgctgtgtg atattcagaa2940gggaagtagt attcaggggg taaacaggtc tcccagcatt ctgagtgttc caaaccagta3000
atccacatgc caattcaaat agaacagccc cttgctagat attaccacag ataatgacag3060tacatggtag aactgcccat gccacaaata tttatttgga aaagtagtca ttaaatgaac3120ccactgcctt aaatgtcttg aatgttgcag tcaagtgtct gtcatgtgtt gatatccaca3180cagaattagg ccctaatgag agccttagac cctcaaccat gcccccttcg ttggcatcac3240agggccttat ttggaagagc ggggcaaaga ggatggaaat cataaaatat ttcatgggaa3300tcgaacctag ggatagtgct ccacttctga cgatggagtg aagacacttg gcagacttga3360gccagacact tcacctagta gttcctgaaa ctgtgagcac cactgcacta agccagtgcg3420gagctgttag ggacgggccc agctcctgca cacggacaca gaatgtctgg agagggcagc3480aggcctctga gggttctgga atctgtgcca ccttatttga ccacactcca aaattctgtt3540tttattttaa cccttgaatc tgctttatgt acataatcaa aatatctata tctatatcta3600tatctatatc tatatatttt taatcatcta catgtaaatg aagcaataga attctaacat3660aaggccaaga aatgagacga atgtttgggg tttatgtttt ttaaggtaaa tacgggtatt3720gtttttaatt attaccatgt attaaattgt gggctttgaa acctaatgaa acctgttagc3780cacttctctg tgccatatac ttcccatgtt accaaaatac gcccaactct ttagccaaaa3840gagaacnctg acctcctgag tttccatgct cctttctgtc aggtttaaat gtagtcttct3900ggagaagtat ttttgacatt gagctctggg acaggacacc ttgggtttgt ggactgcagc3960ccactatgat gttattactt ctctggccag gcctccagtg gaagtgcaca ggcactccca4020atgttgttaa tgctctgtct tccatttgtt ctggaatcct acgtgttggt ctgtggttcc4080atgcattagc tgtttgtaaa taatgcattt gcatactgaa aaaggaatgc cacctgccac4140agttgatggt gagaagctcc tttgacgtgg tgcaattttg atgagatgtc tctggggaca4200cgaggatgcc ctaatgatgc tgacttgtca tggttgcagc atttgaactt ttggtgttaa4260aaaaaaaaac ctgtaagtct gtaacctggc aacattttac aaccctgtat ttttaaagat4320
ggctttctaa taaaaaatcc agaaccacac agccctatgg tcaaacaatc ctacgtttgt4380gcctctgctt ttaaaggtgc tgtgctggac agttggcatg ccagggttcg agaagagtga4440atggcttgac gtccttgcag ttaactgtgc aaaattggct ggctgcctct gttcctactg4500tactgtaact ttgatcatgt ctgttcctat tccattctcc caggagcttc tctgcagact4560gacacaccct cccccacccc gggtagtgga gatgctggtg tctgggtagt catggatttc4620tgctgacatt tgaatgtgat aaacaatcca gcattactta ggaaatgcta catgcggaat4680gtgcacgttt ccaggggcga gtattgtcaa tcaaaaggtt tgcaatgatt tccttcctgc4740caaaaataaa catgtgaaac tgc4763<210>49<211>10300<212>DNA<213>人<400>49aactgctagt ggctgagtcc ctggcggggc gcggcggtgg aaggtgtcgc gtacgggctt60cccgagctga cgtggcttga attgggaggg gggcagctgg agcctcaggc ggcagcgctt120ctagaaatgc tgagccgatt atcaggatta gcaaatgttg ttttgcatga attatcagga180gatgatgaca ctgatcagaa tatgagggct cccctagacc ctgaattaca ccaagaatct240gacatggaat ttaataatac tacacaagaa gatgttcagg agcgcctggc ttatgcagag300caattggtgg tggagctaaa agatattatt agacagaagg atgttcaact gcagcagaaa360gatgaagctc tacaggaaga gagaaaagct gctgataaca aaattaaaaa actaaaactt420catgcgaagg ccaaattaac ttctttgaat aaatacatag aagaaatgaa agcacaagga480gggactgttc tgcctacaga acctcagtca gaggagcaac tttccaagca tgacaagagt540tctacagagg aagagatgga aatagaaaag ataaaacata agctccagga gaaggaggaa600
ctaatcagca ctttgcaagc ccagcttact caggcacagg cagaacaacc tgcacagagt660tctacagaga tggaagaatt tgtaatgatg aagcaacagc tccaggagaa ggaagaattc720attagcactt tacaagccca gctcagccag acacaggcag agcaagctgc acagcaggtg780gtccgagaga aagatgcccg ctttgaaaca caagttcgtc ttcatgaaga tgagcttctt840cagttagtaa cccaggcaga tgtggaaaca gagatgcaac agaaattgag ggtgctgcaa900aggaagcttg aggaacacga agaatccttg gtgggccgtg ctcaggtcgt tgacttgctg960caacaggagc tgactgctgc tgagcagaga aaccagattc tctctcagca gttacagcag1020atggaagctg agcataatac tttgaggaac actgtggaaa cagaaagaga ggagtccaag1080attctactgg aaaagatgga acttgaagtg gcagagagaa aattatcctt ccataatctg1140caggaagaaa tgcatcatct tttagaacag tttgagcaag caggccaagc ccaggctgaa1200ctagagtctc ggtatagtgc tttggagcag aagcacaaag cagaaatgga agagaagacc1260tctcatattt tgagtcttca aaagactgga caagagctgc agtctgcctg tgatgctcta1320aaggatcaaa attcaaagct tctccaagat aagaatgaac aggcagttca gtcagcccag1380accattcagc aactggaaga tcagctccag caaaaatcca aagaaattag ccaatttcta1440aatagactgc ccttgcaaca acatgaaaca gcatctcaga cttctttccc agatgtttat1500aatgagggca cacaggcagt cactgaggag aatattgctt ctttgcagaa gagagtggta1560gaactagaga atgaaaaggg agccttgctc cttagttcta tagagctgga ggagctgaaa1620gctgagaatg aaaaactgtc ttctcagatt actctcctag aggctcagaa tagaactggg1680gaggcagaca gagaagtcag tgagatcagc attgttgata ttgccaacaa gaggagctct1740tctgctgagg aaagtggaca agatgttcta gaaaacacat tttctcagaa acataaagaa1800ttatcagttt tattgttgga aatgaaagaa gctcaagagg aaattgcatt tcttaaatta1860cagctccagg gaaaaagggc tgaggaagca gatcatgagg tccttgacca gaaagaaatg1920
aaacagatgg agggtgaggg aatagctcca attaaaatga aagtatttct tgaagataca1980gggcaagatt ttcccttaat gccaaatgaa gagagcagtc ttccagcagt tgaaaaagaa2040caggcgagca ctgaacatca aagtagaaca tctgaggaaa tatctttaaa tgatgctgga2100gtagaattga aatcaacaaa gcaggatggt gataaatccc tttctgctgt accagatatt2160ggtcagtgtc atcaggatga gttggaaagg ttaaaaagtc aaattttgga gctcgagcta2220aactttcata aagcacaaga aatctatgag aaaaatttag atgagaaagc taaggaaatt2280agcaacctaa accagttgat tgaggagttt aagaaaaatg ctgacaacaa cagcagtgca2340ttcactgctt tgtctgaaga aagagaccag cttctctctc aggtgaagga acttagcatg2400gtaacagaat tgagggctca ggtaaagcaa ctggaaatga accttgcaga agcagaaagg2460caaagaagac ttgattatga aagccaaact gcccatgaca acctgctcac tgaacagatc2520catagtctca gcatagaagc caaatctaaa gatgtgaaaa ttgaagtttt acagaatgaa2580ctggatgatg tgcagcttca gttttctgag cagagtaccc tgataagaag cctgcaaagc2640cagctgcaaa ataaggaaag tgaagtgctt gagggggcag aacgtgtaag gcatatctca2700agtaaagtgg aagaactgtc ccaggctctt tcacagaagg aacttgaaat aacaaaaatg2760gatcagctct tactagagaa aaagagagat gtggaaaccc tccaacaaac catcgaggag2820aaggatcaac aagtgacaga aatcagcttt agtatgactg agaaaatggt tcagcttaat2880gaagagaagt tttctcttgg ggttgaaatt aagactctta aagaacagct aaatttatta2940tccagagctg aggaagcaaa aaaagagcag gtggaagaag ataatgaagt ttcttctggc3000cttaaacaaa attatgatga gatgagccca gcaggacaaa taagtaagga agaacttcag3060catgaatttg accttctgaa gaaagaaaat gagcagagaa agagaaagct ccaggcagct3120cttattaaca gaaaggagct tctgcaaaga gtcagtagat tggaagaaga attagccaac3180ttgaaagatg aatctaagaa agaaatccca ctcagtgaga ctgagagggg agaagtggaa3240
gaagataaag aaaacaaaga atactcagaa aaatgtgtga cttctaagtg ccaagaaata3300gaaatttatt taaaacagac aatatctgag aaagaagtgg aactacagca tataaggaag3360gatttggaag aaaagctggc agctgaagag caattccagg ctctggtcaa acagatgaat3420cagaccttgc aagataaaac aaaccaaata gatttgctcc aagcagaaat cagtgaaaac3480caagcaatta tccagaagtt aatcacaagt aacacggatg caagtgatgg ggactccgta3540gcacttgtaa aggaaacagt ggtgataagt ccaccttgta caggtagtag tgaacactgg3600aaaccagaac tagaagaaaa gatactggcc cttgaaaaag aaaaggagca acttcaaaag3660aagctacagg aagccttaac ctcccgcaag gcaattctta aaaaggcaca ggagaaagaa3720agacatctca gggaggagct aaagcaacag aaagatgact ataatcgctt gcaagaacag3780tttgatgagc aaagcaagga aaatgagaat attggagacc agctaaggca actccagatt3840caagtaaggg aatccataga cggaaaactc ccaagcacag accagcagga atcgtgttct3900tccactccag gtttagaaga acctttattc aaagccacag aacagcatca cactcaacct3960gttttagagt ccaacttgtg cccagactgg ccttctcatt ctgaagatgc gagtgctctg4020cagggcggaa cttctgttgc ccagattaag gcccagctga aggaaataga ggctgagaaa4080gtagagttag aattgaaagt tagttctaca acaagtgagc ttactaaaaa atcagaagag4140gtatttcagt tacaagagca gataaataaa cagggtttag aaatcgagag tctaaagaca4200gtatcccatg aagctgaagt ccatgccgaa agcctgcagc agaaattgga aagcagccaa4260ctacaaattg ctggcctaga acatctaaga gaattgcaac ctaaactgga tgaactgcaa4320aaactcataa gcaaaaagga agaagacgtt agctaccttt ctggacaact tagtgagaaa4380gaagcagctc tcactaaaat acagacagag ataatagaac aagaagattt aattaaggct4440ctgcatacac agctagaaat gcaagccaaa gagcatgatg agaggataaa gcagctacag4500gtggaacttt gtgaaatgaa gcaaaaacca gaagagattg gagaagaaag tagagcaaag4560
caacaaatac aaaggaaact gcaagctgcc cttatttccc gaaaagaagc actaaaagaa4620aacaaaagtc tccaagagga attgtctttg gccagaggta ccattgaacg tctcaccaag4680tctctggcag atgtggaaag ccaagtttct gctcaaaata aagaaaaaga tacggtctta4740ggaaggttag ctcttcttca agaagaaaga gacaaactca ttacagaaat ggacaggtct4800ttattggaaa atcagagtct cagcagctcc tgtgaaagtc taaaactagc tctagagggt4860cttactgaag acaaggaaaa gttagtgaag gaaattgaat ctttgaaatc ttctaagatt4920gcagaaagta ctgagtggca agagaaacac aaggagctac aaaaagagta tgaaattctt4980ctgcagtcct atgagaatgt tagtaatgaa gcagaaagga ttcagcatgt ggtggaagct5040gtgaggcaag agaaacaaga actgtatggc aagttaagaa gcacagaggc aaacaagaag5100gagacagaaa agcagttgca ggaagctgag caagaaatgg aggaaatgaa agaaaagatg5160agaaagtttg ctaaatctaa acagcagaaa atcctagagc tggaagaaga gaatgaccgg5220cttagggcag aggtgcaccc tgcaggagat acagctaaag agtgtatgga aacacttctt5280tcttccaatg ccagcatgaa ggaagaactt gaaagggtca aaatggagta tgaaaccctt5340tctaagaagt ttcagtcttt aatgtctgag aaagactctc taagtgaaga ggttcaagat5400ttaaagcatc agatagaaga taatgtatct aaacaagcta acctagaggc caccgagaaa5460catgataacc aaacgaatgt cactgaagag ggaacacagt ctataccagg tgagactgaa5520gagcaagact ctctgagtat gagcacaaga cctacatgtt cagaatcggt tccatcagcg5580aagagtgcca accctgctgt aagtaaggat ttcagctcac atgatgaaat taataactac5640ctacagcaga ttgatcagct caaagaaaga attgctggat tagaggagga gaagcagaaa5700aacaaggaat ttagccagac tttagaaaat gagaaaaata ccttactgag tcagatatca5760acaaaggatg gtgaactaaa aatgcttcag gaggaagtaa ccaaaatgaa cctgttaaat5820cagcaaatcc aagaagaact ctccagagtt accaaactaa aggagacagc agaagaagag5880
aaagatgatt tggaagagag gcttatgaat caattagcag aacttaatgg aagcattggg5940aattactgtc aggatgttac agatgcccaa ataaaaaatg agctattgga atctgaaatg6000aagaacctta aaaagtgtgt gagtgaattg gaagaagaaa agcagcagtt agtcaaggaa6060aaaactaagg tggaatcaga aatacgaaag gaatatttgg agaaaataca aggtgctcag6120aaagaacccg gaaataaaag ccatgcaaag gaacttcagg aactgttaaa agaaaaacaa6180caagaagtaa agcagctaca gaaggactgc atcaggtatc aagagaaaat tagtgctctg6240gagagaactg ttaaagctct agaatttgtt caaactgaat ctcaaaaaga tttggaaata6300accaaagaaa atctggctca agcagttgaa caccgcaaaa aggcacaagc agaattagct6360agcttcaaag tcctgctaga tgacactcaa agtgaagcag caagggtcct agcagacaat6420ctcaagttga aaaaggaact tcagtcaaat aaagaatcag ttaaaagcca gatgaaacaa6480aaggatgaag atcttgagcg aagactggaa caggcagaag agaagcacct gaaagagaag6540aagaatatgc aagagaaact ggatgctttg cgcagagaaa aagtccactt ggaagagaca6600attggagaga ttcaggttac tttgaacaag aaagacaagg aagttcagca acttcaggaa6660aacttggaca gtactgtgac ccagcttgca gcctttacta agagcatgtc ttccctccag6720gatgatcgtg acagggtgat agatgaagct aagaaatggg agaggaagtt tagtgatgcg6780attcaaagca aagaagaaga aattagactc aaagaagata attgcagtgt tctaaaggat6840caacttagac agatgtccat ccatatggaa gaattaaaga ttaacatttc caggcttgaa6900catgacaagc agatttggga gtccaaggcc cagacagagg tccagcttca gcagaaggtc6960tgtgatactc tacaggggga aaacaaagaa cttttgtccc agctagaaga gacacgccac7020ctataccaca gttctcagaa tgaattagct aagttggaat cagaacttaa gagtctcaaa7080gaccagttga ctgatttaag taactcttta gaaaaatgta aggaacaaaa aggaaacttg7140gaagggatca taaggcagca agaggctgat attcaaaatt ctaagttcag ttatgaacaa7200
ctggagactg atcttcaggc ctccagagaa ctgaccagta ggctgcatga agaaataaat7260atgaaagagc aaaagattat aagcctgctt tctggcaagg aagaggcaat ccaagtagct7320attgctgaac tgcgtcagca acatgataaa gaaattaaag agctggaaaa cctgctgtcc7380caggaggaag aggagaatat tgttttagaa gaggagaaca aaaaggctgt tgataaaacc7440aatcagctta tggaaacact gaaaaccatc aaaaaggaaa acattcagca aaaggcacag7500ttggattcct ttgttaaatc catgtcttct ctccaaaatg atcgagaccg catagtgggt7560gactatcaac agctggaaga gcgacatctc tctataatct tggaaaaaga ccaactcatc7620caagaggctg ctgcagagaa taataagctt aaagaagaaa tacgaggctt gagaagtcat7680atggatgatc tcaattctga gaatgccaag ctagatgcag aactgatcca atatagagaa7740gacctgaacc aagtgataac aataaaggac agccaacaaa agcagcttct tgaagttcaa7800cttcagcaaa ataaggagct ggaaaataaa tatgctaaat tagaagaaaa gctgaaggaa7860tctgaggaag caaatgagga tctgcggagg tcctttaatg ccctacaaga agagaaacaa7920gatttatcta aagagattga gagtttgaaa gtatctatat cccagctaac aagacaagta7980acagccttgc aagaagaagg tactttagga ctctatcatg cccagttaaa agtaaaagaa8040gaagaggtac acaggttaag tgctttgttt tcctcctctc aaaagagaat tgcagaactg8100gaagaagaat tggtttgtgt tcaaaaggaa gctgccaaga aggtaggtga aattgaagat8160aaactgaaga aagaattaaa gcatcttcat catgatgcag ggataatgag aaatgaaact8220gaaacagcag aagagagagt ggcagagcta gcaagagatt tggtggagat ggaacagaaa8280ttactcatgg tcaccaaaga aaataaaggt ctcacagcac aaattcagtc ttttggaagg8340tctatgagtt ccttgcaaaa tagtagagat catgccaatg aggaacttga tgaactgaaa8400aggaaatatg atgccagtct gaaggaattg gcacagttga aagaacaggg actcttaaac8460agagagagag atgctcttct ttctgaaacc gccttttcaa tgaactccac tgaggagaat8520
agcttgtctc accttgagaa acttaaccaa cagctcctat ccaaagatga gcaattgctt8580cacttgtcct cacaactaga agattcttat aaccaagtgc agtccttttc caaggctatg8640gccagtctgc agaatgagag agatcacctg tggaatgagc tggagaaatt tcgaaagtca8700gaggaaggga agcagaggtc tgcagctcag ccttccacca gcccagctga agtacagagt8760ttaaaaaaag ctatgtcttc actccaaaat gacagagaca gactactgaa ggaattgaag8820aatctgcagc agcaatactt acagattaat caagagatca ctgagttaca tccactgaag8880gctcaacttc aggagtatca agataagaca aaagcatttc agattatgca agaagagctc8940aggcaggaaa acctctcctg gcagcatgag ctgcatcagc tcaggatgga gaagagttcc9000tgggaaatac atgagaggag aatgaaggaa cagtacctta tggctatctc agataaagat9060cagcagctca gtcatctgca gaatcttata agggaattga ggtcttcttc ctcccagact9120cagcctctca aagtgcaata ccaaagacag gcatccccag agacatcagc ttccccagat9180gggtcacaaa atctggttta tgagacagaa cttctcagga cccagctcaa tgacagctta9240aaggaaattc accaaaagga gttaagaatt cagcaactga acagcaactt ctctcagcta9300ctggaagaga aaaacaccct ttccattcag ctctgcgata ccagtcagag tcttcgtgag9360aaccagcagc actatggtga ccttttaaat cactgtgcag tcttggagaa gcaggttcaa9420gagctgcagg cggggccact aaatatagat gttgctccag gagctcccca ggaaaagaat9480ggagttcaca gaaagagtga ccctgaggaa ctaagggaac cgcagcaaag cttttctgaa9540gctcagcagc agctatgcaa caccagacag gaagtgaatg aattaaggaa gctgctggaa9600gaagaacgag accaaagagt ggctgctgag aatgctctct ctgtggccga ggagcagatc9660agacggttag agcacagtga atgggactct tcccggactc ctatcattgg ctcctgtggc9720actcaggagc aggcactgtt aatagatctt acaagcaaca gttgtcgaag gacccggagt9780ggcgttggat ggaagcgagt cctgcgttca ctctgtcatt cacggacccg agtgccactt9840
ctagcagcca tctactttct aatgattcat gtcctgctca ttctgtgttt tacgggccat 9900ctatagactt agttgttact ctttggacca ctcccttcaa aacttggaat tctctcacct 9960ctaacatcag aacatcaatt ccagtggaac agtcttccca tttacaggtc ttctctccaa 10020ctcttcacgg aaagtgcctg caaaaacaga ggtggatacg aggacaggtt ggagctgcag 10080ggactggcga gtctgctttc ttctactgcc ctgagcctga acgcttctgc ttaatctgag 10140aatcacattt ggtttgttga gcctaatatt tgttgagatt ttgcaggacc ctgatctttt 10200gtggtcctgt aaaagatact gaggaatgtc tttcagccaa gccaagagga tggtttcaat 10260aaacctaata atctgaagtt cagctttttt tttttttttt 10300<210>50<211>2357<212>DNA<213>人<400>50gaggagacgc gctttgtgct gggcgccggc cgcgccagcc acggcctgcg gcgcccgcgg60caccatgatc tccaccaagg agaagaacaa gatcccgaag gacagcatga cgcttctgcc120ctgcttctac ttcgtggagc tgcccatagt ggcttcttcc atcgtatcct tgtacttcct180ggagctgacc gacctcttca agccggccaa ggtgggcttc cagtgctatg accgcactct240ctccatgccc tacgtggaga ccaacgagga gctcatcccg ctgctgatgc tgctcagctt300ggccttcgcg gcccctgccg cctcgatcat ggtggccgag ggcatgttgt actgtctgca360gtcccggctg tggggccgtg ccggggggcc cgccggggcg gagggcagca tcaacgccgg420cggctgcaac ttcaactcct tcctgcggcg tacggtgcgg tttgtgggtg tccacgtgtt480cggcctgtgt gccacagccc tggtgacgga cgtgatccag ctggccacgg gttaccacac540tcccttcttc ctcaccgtct gcaagcccaa ctacactctc ctgggcacgt cctgcgaggt600caacccctac atcacgcagg acatctgctc cggccacgac atccacgcca tcctgtctgc660
acggaagacc ttcccgtccc agcacgccac gctgtcagcc ttcgccgcgg tctatgtgtc720ggtgagtccg gcacctcact gcccttccca ggccctcttg ctgacccgtg gggagccctc780cctgacccca acccccatgc cccagatgta cttcaactcg gtcatctcgg acaccaccaa840gctgctgaag cccatcctgg tcttcgcctt tgccatcgcc gcgggcgtat gcgggctcac900gcagatcacg cagtaccgca gccaccctgt ggacgtgtat gccggcttcc tcatcggggc960gggcatcgct gcctacctgg cctgccacgc ggtgggcaac ttccaggccc cacctgcaga1020gaagcccgcg gccccggccc ccgccaagga cgcgctgcgg gccctgacgc agcggggcca1080cgactcggtt tatcagcaga ataagtcggt gagcaccgac gagctggggc ccccagggcg1140gctggagggc gcgccccggc ccgtggcccg cgagaagacc tcgctgggca gcctgaagcg1200cgccagcgtg gacgtggacc tgctggcccc gcgcagcccc atggccaagg agaacatggt1260gaccttcagc cacacgctgc ccagggccag cgcgccctcg ctggacgacc ccgcgcgccg1320ccacatgacc atccacgtgc cgctggacgc ctcgcgctcc aagcagctca tcagcgagtg1380gaagcagaag agcctggagg gccgcggcct ggggctgccc gacgacgcca gccccgggca1440cctgcgcgcg cccgccgaac ccatggcgga ggaggaggaa gaggaggagg acgaagagga1500agaggaggag gaggaagagg aggaggacga gggcccggcc ccgccctcgc tctaccccac1560cgtgcaggcg cggccggggc tggggcctcg ggtcatcctc ccaccgcgcg cggggccgcc1620gccgctggtg cacatcccgg aggagggcgc gcagacgggg gccggcctgt cccccaaaag1680cggcgccggg gtgcgcgcca agtggctcat gatggccgag aagagcgggg cggcagtggc1740caaccctccg cggctgctgc aggtcatcgc catgtccaag gctccgggcg cgccgggccc1800caaggcggcc gagacggcgt cgtcgtccag cgccagctcc gactcctcgc agtaccggtc1860gccgtcggac cgcgactccg ccagcatcgt gaccatcgac gcgcacgcgc cgcaccaccc1920cgtggtgcac ctgtcggccg gcggcgcgcc ctgggagtgg aaggcggcgg gcggcggggc1980
caaggcggag gccgacggcg gctacgagct gggggacctg gcgcgcggct tccgcggcgg2040ggccaagccc ccgggcgtgt cccccggctc gtcggtcagc gacgtggacc aggaggagcc2100gcggttcggg gccgtggcca ccgtcaacct ggccacgggc gaggggctgc ccccgctggg2160cgcggccgat ggggcgctgg gcccgggcag ccgggagtcc acgctgcggc gccacgcggg2220cggcctgggg ctggcggagc gcgaggcgga ggcggaggcc gagggctact tccgcaagat2280gcaggcgcgc cgcttccccg actagcgcgg cggggccggg ggcgggcggg gggcgggccg2340agggcgcggg cggccgc 2357<210>51<211>3496<212>DNA<213>人<400>51aagattttac tgacaatttg gagctagatg aagaaggagc aggcgggttc acggctaaag60caatcgttca gagagacaga gtggatgaag aggccttgaa tttcccctac gaggatgact120ttgacaacga tgtggatgct ctgctggaag aaggcctttg tgcccccaaa aagaggcgaa180cagaggaaaa atatggcgga gacagcgacc atctgtccga tggagagaca agtgtgcagc240cgatgatgac caagattaaa acagtgctca aaagtcgtgg ccgcccacct acagagccgc300tgcccgacgg gtggatcatg acattccata actctggagt cccggtgtac ctacacagag360agtctcgggt ggtcacctgg tccaggccat acttcttggg aacgggaagc atacggaaat420acgaccctcc tctgagtagc atcccttgtc tgcattataa gaaaatgaag gacaacgagg480aacgggagca aagcagtgac ctcaccccta gtggggatgt gtcccccgtc aagcccctga540gccgatctgc agagctggag tttcccctgg atgagcctga ctctatgggt gctgacccgg600ggcccccgga cgagaaagac ccactagggg ctgaggcagc ccctggggcc ctggggcagg660
tgaaggccaa agtcgaggtg tgcaaagatg aatccgttga tctcgaggaa tttcgaagct720acctggagaa gcgttttgac tttgagcaag ttactgtgaa aaaattcagg acttgggctg780agcggcggca attcaatcgg gaaatgaagc ggaagcaggc ggagtccgag aggcccatct840tgccagccaa tcagaagctc attactttat cagtgcaaga tgcacccaca aagaaagagt900ttgttattaa ccccaacggg aaatccgagg tctgcatcct gcacgagtac atgcagcgtg960tcctcaaggt ccgccctgtc tataatttct ttgaatgtga gaacccaagt gagccttttg1020gtgcctcggt gaccattgat ggtgtgactt acggatctgg aactgcaagc agcaaaaaac1080ttgcgaagaa taaagctgcc cgagctacac tggaaatcct catccctgac tttgttaaac1140agacctctga agagaagccc aaagacagtg aagaactcga gtattttaac cacatcagca1200tcgaggactc gcgggtctac gagctgacca gcaaggctgg gctgttgtct ccatatcaga1260tcctccacga gtgccttaaa agaaaccatg ggatgggtga cacgtctatc aagtttgaag1320tggttcctgg gaaaaaccag aagagtgaat acgtcatggc gtgtggcaag cacacagtgc1380gcgggtggtg taagaacaag agagttggaa agcagttagc ctcacagaag atccttcagc1440tgctgcaccc acatgtcaag aactgggggt ctttactgcg catgtatggc cgtgagagca1500gcaagatggc caagcaggag acatcggaca agagtgtgat tgagctgcag cagtatgcca1560agaagaacaa gcccaacctg cacatcctca gcaagctcca agaggagatg aagaggctag1620ctgaggaaag ggaggagact cgaaagaagc ccaagatgtc cattgtggcg tccgcccagc1680ctggcggtga gcccctgtgc accgtggacg tgtgagggag gtggcacggg ccagggcgcg1740ggggccgcca gccgcacttc tgaggagacc agcagtcatg catcgtgcac cacagtgtca1800ggcctccaac ccacgctcct tccctgtggc caacctgtgg gcccggcctt agggtggaga1860ctttagtgta cagggacagc catggccaca cagcacacat gtggagcagc ggctctccct1920ggaaagctcc aggcctgaat ggatggactc agcgactgca ccagtggcag ctggtgactg1980
tggacagtgg tggaccctgc ttctgtgcac ctgctgcagg ctctttttat gaaggctttc2040atgaatttta gtatgtaata cgcactgacg acacatgatg cttggatgac agatgagagg2100ggatggctga gtcctgtggc tggcccgtga tgccaggtgg cccatgtgcc cagggcgcct2160gcagggctgc tacagggacc tggtcaggag gtgcacatgg tgccctgccc tcacccaccc2220tctgtgtttc cccttctttg aaaaggtaga agagaaagga atattttaaa cctttttggc2280ttaaacagaa ttttagcatc agaactagct ttctgggatt ggaggcaaac catcaaggtg2340gtccctctcc agtctggaca cgatgccagc aaggatgacg tcctgccacc tcctggagtt2400accctggcct cctagggtcc ctttttctga tgaagtctta attccctaaa agcgcctctt2460tggacactga ggccctctct gcctttcctg gcctccggca acagtttttt tacaaagatt2520ttttgcagtc gagtccatat gtccacccat tgatttttaa agcttttgtg atattttagc2580attttgaaag actttcacag tgagagtaga aggtagattt ggaatcatgc attttagcaa2640gtggacttgt tgaaacagga agcaagggcc ttcagtgtag cccattcttg atccagagct2700gttgcctgtg acagcggttt ctctggatgt caaaggcagc tgcctggtgc ccagcttgct2760tctcgactgg tggcccctat gggtgggtgt gcgatggaaa tgtgttcctg ccggagtctg2820aggcaccagg gtgtgctcaa aggctggccc tggtggtgga ctggcacctg tgcagagtgc2880cgtgtgcttg tggtgcgcca tctgaagcaa gagtccagcg ttctgccgtg tctgtccccc2940accatgcccc ctacaggcgg tactgatggc gctttttttt ttttttttct gtcaggaaaa3000caatgttggc ctgtgggccg cccacaacat atccttccct cactacctgt gtgaccaagg3060ttggcttctg ttgacctttt aaaaaagaaa ccctcaactc aaattgctat aattagacac3120ttgcttctgt cttgcctcct gtctgcagct gtgaatagtc atttgactgt gactgttgcc3180cttagccagc cagatgcgcc tgtgaaccaa agcttcgtgc acatgtgttc ccctaaaggt3240tggggagcct cgctgtgtct tgctgttccc aggcaccacc acagcaggtg ctgccatact3300
cttgtggtct ctgtgcgccc cccccccccc cacccgtctg ccaagcatgg gtatgaatcg3360tgcacacagc catgcttcaa ggccggggca ggggagcctg tgctgatgcc atccagggca3420ctgggctgtg cctggaaggc gagccttgat tgtctgaaca cataaagcaa actgtccaga3480aaaaaaaaaa aaaaaa3496<210>52<211>3508<212>DNA<213>人<400>52gcaacagccc agccctagct tgggagcgga cccacacgaa ctgctcaaag gcttggagcg60ggtctagtaa ggcgaacgga ctgcttccgg ccagaggtcc cgggcggagg aggaagctgt120ggctgccggc ggtgggacgc cccggccgct cagcccccgg gcactgctgt ggggcgttca180gctttccaca cttggggcaa agcaagccgc gaggaggaac cagacagtcc tgttagttgt240ggccagccct cattccctgg aaatggcaaa caaggggaac aagaagcgtc ggcagttctc300tctggaggag aaaatgaaag ttgtgggagc tgtagactca ggcaagagga aaggtgatgt360ggcaaaagaa tttggtatca ctccctctac tttatctaca ttcttaaagg atcgcaccaa420atttgaagaa aaggtgcggg aggcatccgt gggaccccag cggaaaagga tgaggagcgc480tctttatgat gacattgata aggctgtttt tgcttggttt caagaaatcc atgccaaaaa540cattcttgtg actggttctg tcattcggaa aaaagcacta aacttggcca acatgcttgg600ctatgacaat tttcaagcaa gtgtgggctg gctgaacaga tttagagatc gccacggaat660tgctttgaaa gcagtctgta gagaagatag tgacaggtta atgaatggtc taggaataga720taagattaat gagtggcatg caggggaaat tataaaactg attgctgact acagcccaga780tgatatcttt aatgctgatg agacaggagt gtttttccag ttgcttcccc agcacacact840tgctgctaaa ggagaccact gtagaggggg caagaaagca aagcagcggt tgacagcact900
cttttgttgc aatgcctcgg ggactgaaaa aatgagacca ttgattgttg gtaggtcagc960cagcccacac tgcctcaaga acattcattc cctcccttgt gattaccgag ccaaccagtg1020ggcttggatg acaagggatc tgtttaatga gtggctgatg caagtggatg ccaggatgaa1080gagggcggaa cgccggatcc tcttgctcat agacaactgc tctgctcata acatgcttcc1140acacttggaa aggattcagg ttgggtatct gccctccaac tgtactgctg tcctgcagcc1200actgaatctt ggcataattc acaccatgaa agtactgtac cagagccacc ttctaaaaca1260gatcctcctc aagctcaaca gcagtgagga tcaagaagag gtggacatca agcaggccat1320cgacatgatt gctgcagcgt ggtggtcagt caagccatcc acagtggtga aatgttggca1380gaaggcaggc atcgtcccta tggaatttgc agaatgtgac acagaatcag cagccagtga1440accagacatt gccattgaaa agttgtggca cacagtggct attgccacct gtgtcccaaa1500tgaagtaaat ttccaggact ttgttactgc agatgatgat ctcattatct ctcaggacac1560agacatcatc caggacatgg tggctggcga aaataccagt gaagcaggaa gtgaagatga1620aggggaggta tctttaccag agcaaccaaa agtcaccatc acagaagcca tatcaagtgt1680acagaaactt agacagttcc tttccacttg tgtagacatt cctgatgcca tttttggaca1740attaaatggc atagatgaat atttaatgaa aagagtgaca caaaccctta ttgattccaa1800aattacagat ttcctccaaa caaaataatg caggaattta tttcagaaaa tgtagtttac1860aagaataaag atttctttag ataggttgtt gagccaattt aagtaaagca atgttattgt1920gacaacattc cagtactctg aaatagccag gaaacttctt tgaatggaat ttgactaata1980tgtgtgtttt cttttctttt gtttttggct gtctctggtc cttgattcaa gatgtatttt2040gattcatcca agggtttcca aacttgtctg caaattagga tcacttgaga atcctttaaa2100aattccaaag ctcaggccat atcccaggcc tattaaatca caatctttgg tgacgggtca2160caggcattgg tagttttgaa gctctccagg tgattccaat gtgcagacaa atttgaaaac2220
tgaaccaacc acaggaacat caagtacact gtgggcctgg gtccagcttc tttccagtaa2280gtgtatctca ggggcttcca aatttagctt acatcagaat cacttggaag gcttgttaaa2340acccaaggct gctaggccca cccccagagt ttgatacagt agacctcagg tgggacccaa2400aaatttgcat ttctaacaca ttctcagctg atgcagtcca ggctccatgc tttgaaaacc2460actggtctag ctttagatag gatattgagc caatttaaat aaagcaatat actggtctag2520ctgagttcta gaacttctct ctttagctgg ccatctgaat actcccccat cactaattgt2580taaaaaaaga atcaactgtt cttactctag agctcttttt tcctttctgc tgatttgctg2640gaagcactac aagacttctg tttgttcgtt cgtttgtttg tttgtttgtt tttaaagatg2700gggtcttgtt atattgccta ggctggaatg cagtggttat tcacaggcat gattataaca2760cactactctc tctaactcct ggcctcaagc catcctccca aatagatggg actactgatg2820cacactgcca tgctggcctt acgaaatgtt ttaataggca tttcactaat agggatctgg2880agtacaagga aatacagtgc atttaagaca taggctgggc atggtggctc atgcctgtaa2940tcccagcaca ttgggaagat cacttgaggc aaggagtttg agaccagact ggccaacaca3000gcgagacccc catctctaaa aaaaaaaaaa ttaataagac atggatacaa ccagggaggg3060aggttataat aatagagcat cctgttaatc agaatcatgg gggagaacat acagcccagc3120gtgcctctca ctttccagaa agggtgagag gatcattaga gagttcatta gagagtattt3180attcctaata agtcagataa atgtcagttt catttttaga agtttcacac aatacctgct3240aatggtgtga tgtcattttt ccccctgctt caggttaatt ttttggatat ttcagaaacc3300catagcaatt cagtgatttt tctttttgta gtagctcagt caaaacaggt aacagcagat3360taatcataga aaatgttgct tccacattaa caaaacaatc actgaaaaac agcagatgtt3420taaatagatt attttatagc ttattttgga tattttttct tttaataaac taatatgatc3480atttgaatta aaaaaaaaaa aaaaaaaa 3508
<210>53<211>1391<212>DNA<213>人<400>53tgcactcacc tcctagagac caggctgcca tcatgctctg gaagcttgtg gagaatgtca60agtacgaaga tatctatgag gaccggcacg atggtgtccc gagccacagc tcgcggctct120cccagctggg ctcggtgtcc caaggaccct actcgagcgc cccgccgctg tcccacaccc180cgtcgtcgga cttccagccg ccctacttcc caccccccta ccagccgctc ccctaccacc240agagccagga cccctactcc cacgtcaacg acccctactc cctgaaccca ctgcaccagc300cccagcaaca tccctggggg caacggcagc ggcaagaagt gggttcggaa gccggctctc360tcctgcccca gcctcgggcc gccttgcccc agctctcggg ccttgacccc cggagggact420accactcggt ccgccggccg gacgtgctgc tgcattcggc gcaccacggc ctggacgcgg480gcatgggtga cagcctctcg ctgcacggcc tcggccatcc cggaatggaa gacgtccagt540cagttgaaga tgccaataac agcggcatga atctattgga ccagtctgtc attaaaaaag600ttccagttcc tcccaaatcg gtgacttctc taatgatgaa taaagacggc ttcctgggag660gcatgtctgt caacaccggc gaggtgtttt gctccgtccc aggccgtttg tctctgctca720gttcaacttc gaagtacaaa gtaactgtgg gagaagttca gagacggctg tcgccccctg780aatgcctcaa tgcatctctc ctcggcggag tcctcagaag agccaaatcg aaaaatgggg840ggagatcttt gcgagaaagg ctagaaaaaa tcggtttgaa tttacccgcg ggcaggcgca900aagcagcaaa tgtcacgtta ctcacctccc tggtggaagg agaagctgtt cacttagcta960gggattttgg gtacatttgc gaaacggagt ttcccgccaa agccgtctct gagtatttga1020accggcagca cacagacccg agtgacctgc actcccgaaa gaatatgctg ttggccacca1080
agcaactttg taaagaattt acggatctac tggcgcagga ccggacaccg atagggaaca1140gccgacccag ccccatcctg gagccgggga tccagagctg cctcacgcac ttcagcctca1200tcacgcacgg cttcggcgcc ccggccattt gcgccgcgct cacggccctg cagaactatc1260tcaccgaggc gctcaaaggc atggacaaga tgttcttgaa caacaccacc actaacaggc1320acacgtctgg ggaaggccca ggtagtaaaa ctggcgacaa ggaggagaaa cacaggaaat1380gaaaaatttt t 1391<210>54<211>4862<212>DNA<213>人<400>54acgcagctcc gccccgcgtc cgacccgcgg atcccgcggc gtccggcccg ggtggtctgg60atcgcggagg gaatgccccg gagggcggag aactgggacg aggccgaggt aggcgcggag120gaggcaggcg tcgaagagta cggccctgaa gaagacggcg gggaggagtc gggcgccgag180gagtccggcc cggaagagtc cggcccggag gaactgggcg ccgaggagga gatggaggcc240gggcggccgc ggcccgtgct gcgctcggtg aactcgcgcg agccctccca ggtcatcttc300tgcaatcgca gtccgcgcgt cgtgctgccc gtatggctca acttcgacgg cgagccgcag360ccctacccaa cgctgccgcc tggcacgggc cgccgcatcc acagctaccg aggtcacctt420tggctcttca gagatgcagg gacacacgat gggcttctgg ttaaccaaac tgaattattt480gtgccatctc tcaatgttga cggacagcct atttttgcca atatcacact gccagtgtat540actctgaaag agcgatgcct ccaggttgtc cggagcctag tcaagcctga gaattacagg600agactggaca tcgtcaggtc gctctacgaa gatctggaag accacccaaa tgtgcagaaa660gacctggagc ggctgacaca ggagcgcatt gcacatcaac ggatgggaga ttgaagattt720ctgttgaaac ttacactgtt tcatctcagc ttttgatggt actgatgagt cttgatctag780
atacaggact ggttccttcc ttagtttcaa agtgtctcat tctcagagta aaataggcac840cattgcttaa aagaaagtta actgacttca ctaggcattg tgatgtttag gggcaaacat900cacaaaatgt aatttaatgc ctgcccatta gagaagtatt tatcaggaga aggtggtggc960atttttgctt cctagtaagt caggacagct tgtatgtaag gaggtttata taagtaattc1020agtgggaatt gcagcatatc gtttaatttt aagaaggcat tggcatctgc ttttaatgga1080tgtataatac atccattcta catccgtagc ggttggtgac ttgtctgcct cctgctttgg1140gaagactgag gcatccgtga ggcagggaca agtctttctc ctctttgaga ccccagtgcc1200tgcacatcat gagccttcag tcagggtttg tcagaggaac aaaccagggg acactttgtt1260agaaagtgct tagaggttct gcctctattt ttgttggggg gtgggagagg ggaccttaaa1320atgtgtacag tgaacaaatg tcttaaaggg aatcattttt gtaggaagca ttttttataa1380ttttctaagt cgtgcacttt ctcggtccac tcttgttgaa gtgctgtttt attactgttt1440ctaaactagg attgacattc tacagttgtg ataatagcat ttttgtaact tgccatccgc1500acagaaaata cgagaaaatc tgcatgtttg attatagtat taatggacaa ataagttttt1560gctaaatgtg agtatttctg ttcctttttg taaatatgtg acattcctga ttgatttggg1620tttttttgtt gttgttgttt tgttttgttt tgtttttttg ggatggagkc tcactcttgt1680cacccaggct ggagtgcagt ggcgccatct cggctcactg caacctctgc ctcctgagtt1740cacgtaatcc tcctgagtag ctgggattac aggtgcctgc caccacgctg gccaattttt1800gtacttttag tagagacagt gtttcgccat gttggccagg ctggtttcaa actcctgacc1860tcaggtgatc cgcccacctc agcctcccaa aatggtggga ttacaggtgt gtgggccacc1920gtgcctggct gattcagcat tttttatcag gcaggaccag gtggacttcc acctccagcc1980tctggtccta ccaatggatt catggagtag cctggactgt ttcatagttt tctaaatgta2040caaattctta taggctagac ttagattcat taactcaaat tcaatgcttc tatcagactc2100
agttttttgt aactaataga tttttttttc cacttttgtt ctactccttc cctaatagct2160ttttaaaaaa atctccccag tagagaaaca tttggaaaag acagaaaact aaaaaggaag2220aaaaaagatc cctattagat acacttctta aatacaatca cattaacatt ttgagctatt2280tccttccagc ctttttaggg cagattttgg ttggttttta catagttgag attgtactgt2340tcatacagtt ttataccctt tttcatttaa ctttataact taaatattgc tctatgttag2400tataagcttt tcacaaacat tagtatagtc tcccttttat aattaatgtt tgtgggtatt2460tcttggcatg catctttaat tccttatcct agcctttggg cacaattcct gtgctcaaaa2520atgagagtga cggctggcat ggtggctccc gcctgtaatc ccagtacttt gggaagccaa2580ggtaagagga ttgcttgagc ccagaacttc aagatgagcc tgggctcata gtgagaaccc2640gtctatacaa aaaattttta aaaattagca tggcggcaca catctgtaat cctagctact2700tggcaggctg aggtgagaag atcattggag tttaggaatt ggaggcggca gtgagtcatg2760agtatgccgc tgcactccag cctgggggac agagcaagac cctgcctcaa aaaaaaaaaa2820aaaaaaaatt caggccggga atggtggttc acgcctgtaa tcccagcact ttggggggtc2880gaggtgggca gatcacctga ggtcaggagt tcgagaccag cctggccaac atggtaaaac2940cccatttcta ctaaaaaata caagaattag ctgggtgtgg tggcgcatgc ctgtaatcct3000agctactcag gaggctgagg caggagaatc acttgacccc aggaggcgaa gattgcagtg3060agctgatatc gcaccattgt actccagcct gtgtgacaga gcaatactct tgtcccaaaa3120aaaaaaaaaa ttcaaatcag agtgaagtga atgagacact ccagttttcc ttctactccg3180aattttagct cctcctttca acattcaaca aatagtcttt tttttttttt tttttttttg3240gggatggagt ctccctctgt tgcccaggct ggagtgcaga ggtgcgatct ctgctcacta3300caagctctgc ctcccgagtt caagtgattc tcctggctca ccctcctgag ctgggattac3360aggcgcctgc caccatgcct ggctaatttt gtgtttttag tggagacggg gtttcaccat3420
gttgtccagg atggtcttga tctcctgacc ttgtgatcca cccacctcag cctcccaaag3480tggtgggatt acaggtgtga gccaccgcgt ccagccagct ttattatttt ttttaagctg3540tctttgtgtc aaaatgatag ttcatgctcc tcttgttaaa acctgcaggc cgagcacagt3600ggctcatgcc tgtaatccca gcattttggg agaccaaggc ggatggatca cctgaggtca3660ggagctcaag accagcctgg ctaacatggt gaaacctcat ctccacttaa aatacaaaaa3720ttgccggccg cggcggctca tgcctgtaat cccagcactt tgggaggcct aggcgggtgg3780atcacgacgt caggaaatcg agaccatcct ggctaacacg ggtgaaaccc cgtctctatt3840aaaaaataga aaaaattagg cgggcgtggt ggtgagcgcc tgtagtccca gctactcgag3900agcctgaggc aggagaatgg catgaacctg gaaggtggag cttgcagtga gctgagatgg3960tgccactgca ctctaacctg ggcgacagag tgagactccg tctcaaaaaa aaaaacaaaa4020accaaaactt atccaggtgt ggcggtgggc gcctgtgagg caggcgaatc tcttgaaccc4080gggaggcgga ggttgcagtg agccaagatc acaccattgc actccagcct gggaaacaag4140agtgaaattc catctcaaaa ccaaattttc aaaaaaaaaa catgccgctt gagtactgtg4200tttttggtgt tgtccaagga aaattaaaac ctgtagcatg aataatgttt gttttcattt4260cgaatcttgt gaatgtatta aatatatcgc tcttaagaga cggtgaagtt cctatttcaa4320gttttttttg ttttgttttg tttttaagct gttttttaat acattaaatg gtgctgagta4380aaggaaatag gcagggtgtg ttgtgtggtg ttttaactag gcgcttctct ctcagagagt4440tttgaaacct gtttacataa aggcccaaga tgggaaggag atccaaacat aagccaccag4500cctcattcca agtctcttct ctttccaacc ctggattttt tttttttatt taacattgtt4560tcttttagct ttatttttct tataaaagaa atgtatcact ataaaaaatt acacactaca4620gaaaaatatt aagaagaaaa acattcacat cggaaacaaa gttttttccc atgaaaacag4680aacccaaaag ggtaagtggt tagtatttca ccagcaatta tgttgagaat aaggccaggc4740
gaggtggctc acgcctgtaa tctcagcact ttgggaggcc agggcaggca gatcatctga4800ggtcaggagt ttgagaccag cctggccaac atggtgaaac cctatctcta ctaaaaatta4860aa 4862<210>55<211>3568<212>DNA<213>人<400>55atagttttca ggttaagaaa gccagaatct ttgttcagcc acactgactg aacagacttt60tagtggggtt acctggctaa cagcagcagc ggcaacggca gcagcagcag cagcagcagc120agcagcagca gcagggctcc tgggataact caggcatagt tcaacactat gggtcctcct180ctgaagctct tcaaaaacca gaaataccag gaactgaagc aggaatgcat caaagacagc240agacttttct gtgatccaac atttctgcct gagaatgatt ctcttttcta caaccgactg300cttcctggaa aggtggtgtg gaaacgtccc caggacatct gtgatgaccc ccatctgatt360gtgggcaaca ttagcaacca ccagctgacc caagggagac tggggcacaa gccaatggtt420tctgcatttt cctgtttggc tgttcaggag tctcattgga caaagacaat tcccaaccat480aaggaacagg aatgggaccc tcaaaaaaca gaaaaatacg ctgggatatt tcactttcgt540ttctggcatt ttggagaatg gactgaagtg gtgattgatg acttgttgcc caccattaac600ggagatctgg tcttctcttt ctccacttcc atgaatgagt tttggaatgc tctgctggaa660aaagcttatg caaagctgct aggctgttat gaggccctgg atggtttgac catcactgat720attattgtgg acttcacggg cacattggct gaaactgttg acatgcagaa aggaagatac780actgagcttg ttgaggagaa gtacaagcta ttcggagaac tgtacaaaac atttaccaaa840ggtggtctga tctgctgttc cattgagtct cccaatcagg aggagcaaga agttgaaact900
gattggggtc tgctgaaggg ccatacctat accatgactg atattcgcaa aattcgtctt960ggagagagac ttgtggaagt cttcagtgct gagaaggtgt atatggttcg cctgagaaac1020cccttgggaa gacaggaatg gagtggcccc tggagtgaaa tttctgaaga gtggcagcaa1080ctgactgcat cagatcgcaa gaacctgggg cttgttatgt ctgatgatgg agagttttgg1140atgagcttgg aggacttttg ccgcaacttt cacaaactga atgtctgccg caatgtgaac1200aaccctattt ttggccgaaa ggagctggaa tcggtgttgg gatgctggac tgtggatgat1260gatcccctga tgaaccgctc aggaggctgc tataacaacc gtgatacctt cctgcagaat1320ccccagtaca tcttcactgt gcctgaggat gggcacaagg tcattatgtc actgcagcag1380aaggacctgc gcacttaccg ccgaatggga agacctgaca attacatcat tggctttgag1440ctcttcaagg tggagatgaa ccgcaaattc cgcctccacc acctctacat ccaggagcgt1500gctgggactt ccacctatat tgacacccgc acagtgtttc tgagcaagta cctgaagaag1560ggcaactatg tgcttgtccc aaccatgttc cagcatggtc gcaccagcga gtttctcctg1620agaatcttct ctgaagtgcc tgtccagctc agggaactga ctctggacat gcccaaaatg1680tcctgctgga acctggctcg tggctacccg aaagtagtta ctcagatcac tgttcacagt1740gctgaggacc tggagaagaa gtatgccaat gaaactgtaa acccatattt ggtcatcaaa1800tgtggaaagg aggaagtccg ttctcctgtc cagaagaata cagttcatgc catttttgac1860acccaggcca ttttctacag aaggaccact gacattccta ttatagtaca ggtctggaac1920agccgaaaat tctgtgatca gttcttgggg caggttactc tggatgctga ccccagcgac1980tgccgtgatc tgaagtctct gtacctgcgt aagaagggtg gtccaactgc caaagtcaag2040caaggccaca tcagcttcaa ggttatttcc agcgatgatc tcactgagct ctaaatctgc2100aatcccagag aatcctgaca aagcgtgcca cccttttatt ttccgtcagg tgccaggtct2160tagttaagat tcacaatctt tagaaagaat gagattcaca ataattaact cttcctctct2220
tctgataaat tccccatacc tcccaatcca agtagcatct gtagctacat aacctatata2280cctccagcag ctggacatgg ggaggcgaca gtcctatcta gacatcatac acatttgcca2340agaaaggatc tctggggctt ccgggggtga gattcaagca ggacaataac aagaggctgg2400acaccctaca gatgtctttg atgttttcag ttgtttgata tatctcccct gtagggcatg2460ttgaggaagg aggagggctg atcaaggcca agctggtcta gcctgacatc ctagctcctg2520actgaacact atagacttcc cagcagcatt tcacccagca gccagagccg gctttaagtc2580cccaaccctt acagacacca ctgccaccac caccaaccac gaccaccacc accaccacca2640ctcaccacca tcatcacctc cggaaagtgt agtcctgccc taacccaagt cacccccgac2700agtaaatttt accttcatgt tgagaaagct tcctggtgct taatcaagag ctggagttca2760atgagtccta gacagtgaga ggggcctgag cttcagctca atggaagcct gctgtgtgcc2820acaagacgga aaagtggaag aagctgcagt gggagacaaa gcctcggtcc cccacccatc2880cacacacacc tacactcaca cacgcgcaca tgggcgcgca cgaactacca ttcaggcagt2940cagtgggcaa gaggaaagat aagtaagtac catacacacc taaaagatga gagaattcat3000ccagacatat tacagccagt ttggggcccc tgactgcaat gtgaaacctc tcgctgctgc3060taggtttaca aacaagccca ttgtcctgtg cctcctaata tcatttgtac tgaagacccc3120atctggggac ttgagacttt ggtcccagcc cagactcctc agacttttct ctcagttggg3180atgcttcact cgctgggggt gtttgtttgc cctctcattt ttcagtactt ctacagaatt3240ttctctagag tcagtcatta tgaaatgtac ttccctccat cttaacctat caactttctg3300cccctccttc aaggcccagt ataaatgcca cctcctccat gaagccttcc ctaattccac3360cccaaacccc caccttcaac aatatttcaa cgcttctgca atgatgaaaa agaaacatag3420ttgtagtact tagcctacct agaccagcaa gcattcattt ttagctcgct cattttttac3480catgttttcc agtctgttta acttctgcag tgccttcact acactgcctt acataaacca3540
aatcacaata aagttcatat tcagtaca 3568<210>56<211>1955<212>DNA<213>人<400>56gaattcacca agcgttggat tgttcaccca ctaataggga acgtgagctg ggtttagacc60gtcgtgagac aggttagttt taccctactg atgatgtgtt gttgccatgg taatcctgct120cagtacgaga ggaaccgcag gttcagacat ttggtgtatg tgcttggctg aggagccaat180ggggcgaacg taccatctgt gggattatga ctgaacgcct ctaagtcaga atcccgccca240ggcgaacgat acggcagcgc cgcggagcct cggttggcct cggatagccg gtcccccgcc300tgtccccgcc ggcgggccgc ccccccctcc agcgccccgc gcgcgcggga gggcgcgtgc360cccgccgcgc gccgggaccg gggtccggtg cggagtgccc ttcgtcctgg gaaacggggc420gcggccggaa aggcggccgc cccctcgccc gtcacgcacc gcacgttcgt ggggaacctg480gcgctaaacc attcgtagac gacctgcttc tgggtcgggg tttcgtacgt agcagagcag540ctccctcgct gcgatctatt gaaagtcagc cctcgacaca agggtttgtc cgcgcgcgcg600gcggcgtgcg tgcggggggc ccggcggggc gtgcgcgtcc ggcgccgtcc gtccttccgt660tcgtcttcct ccctcccggc ctctccgccg accgcgggcg tggtgggggg gtgggggggg720gacgcgcgac cccggtcggc gcgccccgct tcttcggttc ccgcctcctc cccgttcacc780gcggggcggc tcgtccgctc cgggccggga cggggtccgg ggagcgtggt ttgggagccg840cggaggcggc cgcgccgagc cgggcccgtg cgcggtcccc gtcccggggg ttggccgcgc900gggccccggt ggggccaccc ggggtcccgg ccctcgcgcg tccttcctct cgctcctccg960cacgggtcga ccagcagacc gcgggtggtg ggcggcgggc ggcgaggccg cacgggcgtc 1020cccgcacccg gccgacctcc gctcgtgacc tctcctcggt cgggctccgg ggtcgaccgc 1080
ctgccccgcg ggcgtgagac tcagccgctg tctcgccgtg tcccgggtcg accggcgggc1140ttctccaccg agcggcgtgt aggagtgccc gtcgggacga accgcaaccg gagcgtcccc1200gtctcggtcg gcacctccgg ggtcgaccag ctgccgcccg cgagctccgg acttagccgg1260cgcctgcacg tgtcccgggt cgaccagcag gcggccgcga cgtgcggcgc accgacgaga1320gggcgtgcat tcccgttcgc gcgcccggac cctccaccgg cctgggcccg acggtggagc1380tgggaccacg cggaactccc tctcctacat ttttttcagc cccaccgcga gtttgcgtcc1440gcgggatttt aagagggagt cactgctgcc gtcagccagt aatgcttcct ccttttttgc1500ttttaggttt tgctcttgcc tttttttttt tttttttctt tctttctttc tttctttctt1560tctttctttc tttctttctt tctttctcgc tctcgcctct cgctctctcc ctcgctcgtt1620ttctttctct ttctctttct ctctctctct ctctctctct ctctctgtct ctcgctctcg1680ccctctctct ctctctcttc tctctgtctc tctctgtctc tctctctctc tctctctctc1740tctctctctc tctctctctc tctctctccc tccccctccc tccctctctc cccttccttg1800gtgccttctc ggctcttgac acttagccgc tgtctcgccg tgtcccgggt cgaccggcgg1860gccttctcca ccgagcggcg tgtaagagtg cccgtcggga cgagccggac ccgccgcgtc1920cccgtctcgg tcggcactcc ggggtcgacc agctg 195权利要求
1.一种评估乳癌状况的方法，包括在选自由Seq ID No.1-56组成的小组的基因组合中，鉴定每个基因相对于正常种群中相同基因的表达的差异性调节。
2.权利要求1所述的方法，其中所述的被调节基因的表达至少存在2倍的差异。
3.权利要求1所述的方法，其中所选择的基因是那些可作为复发或转移指示剂的上调基因。
4.权利要求1所述的方法，其中所选择的基因是那些可作为复发或转移指示剂的下调基因。
5.权利要求1所述的方法，其中所选择的基因包括Seq ID No.1-56的全部。
6.权利要求1所述的方法，其中指示差异调节的p值小于0.05。
7.权利要求1所述的方法，进一步包括非遗传基础的乳腺标记。
8.权利要求7所述的方法，其中所述的非遗传基础的标记选自ER和雌激素调控的蛋白和肽。
9.权利要求1所述的方法，其中所述的基因包括表4中所示的基因。
10.权利要求1所述的方法，其中所述的基因包括表5中所示的基因。
11.权利要求1所述的方法，其中所述的基因包括表6中所示的基因。
12.权利要求1所述的方法，其中所述的基因包括表7中所示的基因。
13.一种预后文库，包括从选自由Seq ID No.1-56组成的小组中的基因组合中分离的核酸序列、它们的互补序列或其部分序列。
14.权利要求13所述的文库，包含于适合鉴定基因差异表达的矩阵中。
15.权利要求14所述的文库，其中所述的矩阵用于微阵列。
16.权利要求15所述的文库，其中所述的微阵列是cDNA微阵列。
17.权利要求15所述的文库，其中所述的微阵列是寡核苷酸微阵列。
18.一种用于确定乳癌病人预后的试剂盒，包括用于检测从选自由Seq IDNo.1-56组成的小组的基因组合中分离的核酸序列、它们的互补序列或其部分序列的物质。
19.权利要求18所述的试剂盒，包括用于进行微阵列分析的试剂。
20.权利要求18所述的试剂盒，进一步包括一种介质，从而所述的核酸序列、它们的互补序列或其部分序列能通过其进行分析。
21.权利要求18所述的试剂盒，其中所述的基因包括表4中所示的基因。
22.权利要求18所述的试剂盒，其中所述的基因包括表5中所示的基因。
23.权利要求18所述的试剂盒，其中所述的基因包括表6中所示的基因。
24.权利要求18所述的方法，其中所述的基因包括表7中所示的基因。
25.一种评估乳癌的治疗效果的方法，包括在选自由Seq ID No.1-56组成的小组中的基因组合中，鉴定每个基因相对于正常种群中相同基因的表达的差异性调节。
26.权利要求25所述的方法，其中所述的基因包括表4中所示的基因。
27.权利要求25所述的方法，其中所述的基因包括表5中所示的基因。
28.权利要求25所述的方法，其中所述的基因包括表6中所示的基因。
29.权利要求25所述的方法，其中所述的基因包括表7中所示的基因。
30.评估乳癌状况的制品，包括用于检测选自由Seq ID No.1-56组成的小组的基因组合中的核苷酸序列、它们的互补序列或其部分序列的物质。
31.权利要求30所述的制品，其中所选择的基因是上调的并进一步选自SeqID No.1-26和Seq ID No.56。
32.权利要求30所述的制品，其中所选择的基因是下调的并进一步选自SeqID No.27-55。
33.权利要求30所述的制品，其中所述的基因包括表4中所示的基因。
34.权利要求30所述的制品，其中所述的基因包括表5中所示的基因。
35.权利要求30所述的制品，其中所述的基因包括表6中所示的基因。
36.权利要求30所述的制品，其中所述的基因包括表7中所示的基因。
全文摘要
一种通过分析一组基因的表达从而提供乳癌预后的方法。还包括存在于各种介质例如微阵列中的基因表达模式，例如含有其的试剂盒。
文档编号C12N15/09GK1715421SQ20041004309
公开日2006年1月4日 申请日期2004年4月23日 优先权日2003年4月24日
发明者Y·王 申请人:维里德克斯有限责任公司