描述
本发明涉及her-3的抑制剂与放射治疗组合用于治疗过度增生性疾病的用途。
人表皮生长因子受体3(her-3，也称作erbb3)是一种受体蛋白酪氨酸激酶并属于受体蛋白酪氨酸激酶的表皮生长因子受体(egfr)亚家族，所述亚家族还包括her-1(也称作egfr)、her-2和her-4(plowman等人,proc.natl.acad.sci.u.s.a.87(1990),4905-4909；kraus等人,proc.natl.acad.sci.u.s.a.86(1989),9193-9197；和kraus等人,proc.natl.acad.sci.u.s.a.90(1993),2900-2904)。如同原型表皮生长因子受体，跨膜受体her-3由一个胞外配体结合结构域(ecd)、一个在ecd内部的二聚化结构域、一个跨膜结构域、一个胞内蛋白酪氨酸激酶结构域(tkd)和一个c末端磷酸化结构域组成。
配体神经生长因子(hrg)与her-3的胞外结构域结合并且通过促进与其他人表皮生长因子受体(her)家族成员二聚化和其胞内结构域的转磷酸化激活受体介导的信号传导途径。her家族成员之间的二聚体形成扩展了her-3的信号传导潜力并且是用于信号多样化和信号放大的手段。例如，her-2/her-3异二聚体在her家族成员之间诱导最重要的促有丝分裂信号之一。
已经发现her-3在几个类型的癌症如乳腺癌、胃肠癌和胰腺癌中过量表达。有趣地，已经显示在her-2/her-3表达和从非浸润期进展至浸润性期之间的相关性(alimandi等人,oncogene10,1813-1821；defazio等人,cancer87,487-498；naidu等人,br.j.cancer78,1385-1390)。因此，需要干扰her-3介导的信号传导的药物。已经报道鼠her-3抗体或嵌合her-3抗体，如在us5968511、us5480968和wo03013602中。
本发明的目的是提供基于抑制her-3治疗过度增生性疾病，尤其癌症，这比从现有技术已知是更有效的。通过使用与放射治疗组合用于治疗过度增生性疾病的her-3抑制剂，解决这个目的。
根据第一方面，本发明涉及her-3的抑制剂与放射治疗组合用于治疗过度增生性疾病的用途。
her-3抑制剂和放疗法组合的治疗导致协同效应，所述协同效应超过单独用her-3抑制剂或放疗法治疗的优势。
本发明的her-3抑制剂根据可以在蛋白质水平或在核酸水平发挥作用。在核酸水平发挥作用的抑制剂的例子是本领域技术人员已知的并且包含反义分子、rnai分子和/或核酶。
在蛋白质水平发挥作用的抑制剂的例子是抗her-3抗体或其抗原结合片段以及支架蛋白。作为抗her-3抗体或其片段、尤其其抗原结合片段的抑制剂代表本发明的优选实施方案。根据本发明，术语“抗体片段”包含前文提到的抗体的任何部分，优选地其抗原结合区或可变区。
如本文所用，“支架蛋白”表示具有抗体样结合活性的蛋白质或抗体即抗her-3抗体。在本发明的上下文中，如本文所用，术语“支架蛋白”意指具有其中高度可耐受氨基酸插入、置换或缺失的暴露表面区域的多肽或蛋白质。可以根据本发明使用的支架蛋白的例子是来自金黄色葡萄球菌(staphylococcusaureus)的蛋白a、来自大菜粉蝶(pierisbrassicae)的胆汁三烯结合蛋白或其他脂笼蛋白、锚蛋白重复序列蛋白和人纤连蛋白(综述于binz和plückthun，curropinbiotechnol.,459-69)。此外，具有抗体样结合活性的支架蛋白可以源自含有支架结构域的接纳体多肽(acceptorpolypeptide)，其中所述接纳体多肽可以用供体多肽的结合结构域移植，以赋予供体多肽结合到含有支架结构域的接纳体多肽上的特异性。
本发明的抗her-3抗体可以是单克隆抗体、多克隆抗体、重组抗体、人抗体、人源化抗体、嵌合抗体、多特异性抗体或其抗原结合片段。特别优选使用单克隆抗体。本领域技术人员知晓怎样产生这类抗体。单克隆抗体可以例如通过任何合适的方法如
本发明的抗体片段根据优选地是fab片段、fab’片段、f(ab’)2片段、fv片段、双体抗体或单链抗体分子。“fab片段”因在重链ch1结构域的羧基端处附加额外几个残基(包括来自抗体铰链区的一个或多个半胱氨酸)而与“fab'片段”不同。“f(ab’)2片段“最初作为一对在其之间具有铰合部半胱氨酸的“fab’片段”产生。根据本发明，“fv片段”是含有完整抗原识别和结合位点的最小抗体片段。
根据本发明使用的抗体可以优选地是igg1、igg2、igg3或igg4抗体类型。
抗体的人源化形式代表又一个优选的实施方案并且可以根据本领域已知的方法如人源化或cdr移植来产生。用于产生人源化抗体的替代性方法是本领域熟知的并且例如在ep0239400和wo90/07861中描述。人抗体避免了与异种抗体(例如拥有小鼠或大鼠可变区和/或恒定区的抗体)相关的某些问题。单克隆的人源化抗her-3抗体代表本发明的一个特别优选的实施方案。
根据又一个优选的实施方案，该抗体针对her-3的胞外结构域。抗her-3抗体优选地与her-3胞外部分中的至少一个表位相互作用。所述表位优选地位于作为氨基端结构域的结构域l1(aa19-184)中、位于两个半胱氨酸丰富结构域的结构域s1(aa185-327)和s2(aa500-632)中或位于旁侧分布有这两个半胱氨酸丰富结构域的结构域l2(328-499)中。所述表位也可以位于结构域的任何组合中，如，但不限于，由l1和s2的部分构成的表位。
所用的抗her-3抗体可以与效应子基团和/或标记基团偶联。相应偶联和/或标记技术是本领域技术人员已知的。可以连接这类效应子基团和/或标记基团用于药物打靶、成像应用和/或诊断性应用。
如本文所用，术语“标记基团”指可检测标记，例如放射标记的氨基酸或可以通过标记的抗生物素蛋白检测到的生物素基部分(例如与荧光标记结合的链霉亲和素或可以通过光学方法或比色方法检测到的酶活性)。合适的标记基团的例子包括但不限于以下：放射性同位素或放射性核素(例如3h、14c、15n、35s、90y、99tc、111in、125i、131i)、荧光基团(例如fitc、罗丹明、镧系元素磷光体)、酶促基团(例如辣根过氧化物酶、(β-半乳糖苷酶、萤光素酶、碱性磷酸酶)、化学发光基团、生物素基团或由第二(secondary)报道分子识别的预定多肽表位(例如亮氨酸拉链对序列、第二抗体结合位点、金属结合结构域、表位标签)。在某些方面，可能想要的是标记基团由各种长度的间隔臂连接以减少潜在的空间位阻。
可选地，根据本发明使用的抗her-3抗体可以与效应子基团偶联。如本文所用，术语“效应子基团”指细胞毒性基团如放射性同位素或放射性核素、毒素、治疗性基团或本领域已知的其他效应子基团。合适的效应子基团的例子是放射性同位素或放射性核素(例如3h、14c、15n、35s、90y、99tc、111in、125i、131i)、刺孢霉素、海兔毒素(dolastatin)类似物如澳瑞司他汀、和化疗药如格尔德霉素及美坦辛衍生物，包括dm1。在某些方面，可能想要的是效应子基团由各种长度的间隔臂连接以减少潜在的空间位阻。
除抑制her-3之外，根据又一个优选的实施方案可以通过用上文所概述的相应效应子基团如放射性同位素或放射性核素标记抗her-3抗体，实施或支持放射治疗。
另外，所用的her-3抑制剂和尤其根据本发明使用的抗her-3抗体可以进一步表征，在于它与her-3的结合减少her-3介导的信号转导。根据本发明，her-3介导的信号转导减少可以例如由导致至少部分her-3分子从细胞表面消失的her-3下调引起或由稳定化细胞表面上的her-3处于基本上无活性的形式(即，与非稳定化形式相比展示出较低信号传导的形式)引起。可选地，也可以通过例如以下方式引起her-3介导的信号转导减少：减少或抑制配体或her家族的另一个成员与her-3的结合、grb2与her-2的结合或grb2与shc的结合、抑制受体酪氨酸磷酸化、akt磷酸化、pyk2酪氨酸磷酸化或erk2磷酸化或减少肿瘤侵入性。可选地，也可以通过例如以下方式引起her-3介导的信号转导减少：减少或抑制与其他her家族成员形成含有her-3的二聚体。连同其他例子，一个例子可以是减少或抑制her3-egfr蛋白质复合物形成。
优选的根据本发明使用的抗her-3抗体在pct/ep2006/012632中描述。
根据一个特别优选的实施方案，该抗体包含重链氨基酸序列，所述重链氨基酸序列包含选自以下cdr的至少一个cdr：(a)如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh1；(b)如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh2；和(c))如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh3
或与根据(a)至(c)的cdr之一显示至少90％、92％、94％、96％、97％、98％、99％同源性的重链氨基酸序列。
根据又一个优选的实施方案，该抗体包含轻链氨基酸序列，所述轻链氨基酸序列包含选自以下cdr的至少一个cdr：(d)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl1；(e)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl2；和(f)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl3，或
与根据(d)至(f)的cdr之一显示至少90％、92％、94％、96％、97％、98％、99％同源性的轻链氨基酸序列。
在本发明的又一个实施方案中，该抗体包含了包含选自以下cdr的至少一个cdr的重链氨基酸序列：
(a)如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh1；
(b)如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh2；和
(c)如seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230中所示的cdrh3，
和包含选自以下cdr的至少一个cdr的轻链氨基酸序列
(d)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl1；
(e)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl2：和
(f)如seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232中所示的cdrl3。
根据又一个优选的实施方案，该抗体包含cdrh1、cdrh2、cdrh3、cdrl1、cdrl2和cdrl3。
根据又一个优选的实施方案，根据本发明使用的抗her-3抗体包含选自seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230的重链氨基酸序列。
又一个优选的实施方案涉及抗her-3抗体的用途，所述抗her-3抗体包含选自seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232的轻链氨基酸序列。
根据又一个优选的实施方案，根据本发明使用的抗her-3抗体包含选自seqidnos:2、6、10、14、18、22、26、30、34、36、40、42、46、50、54、60、62、66、70、74、78、80、84、88、92、96、100、104、108、112、116、120、122、126、130、134、138、142、146、150、154、158、162、166、170、174、178、182、186、190、194、198、202、206、210、214、218、222、226和230的重链氨基酸序列；和选自seqidnos:4、8、12、16、20、24、28、32、38、44、48、52、56、58、64、68、72、76、82、86、90、94、98、102、106、110、114、118、124、128、132、136、140、144、148、152、156、160、164、168、172、176、180、184、188、192、196、200、204、208、212、216、220、224、228和232的轻链氨基酸序列。
特别优选的实施方案涉及抗her-3抗体，所述抗her-3抗体包含seqidno:42的重链氨基酸序列和seqidno:44轻链氨基酸序列，或包含seqidno:54的重链氨基酸序列和seqidno:56轻链氨基酸序列，或包含seqidno:70的重链氨基酸序列和seqidno:72轻链氨基酸序列。
特别地，抗her-3抗体选自u1-1抗体、u1-2抗体、u1-3抗体、u1-4抗体、u1-5抗体、u1-6抗体、u1-7抗体、u1-8抗体、u1-9抗体、u1-10抗体、u1-11抗体、u1-12抗体、u1-13抗体、u1-14抗体、u1-15抗体、u1-16抗体、u1-17抗体、u1-18抗体、u1-19抗体、u1-20抗体、u1-21抗体、u1-22抗体、u1-23抗体、u1-24抗体、u1-25抗体、u1-26抗体、u1-27抗体、u1-28抗体、u1-29抗体、u1-30抗体、u1-31抗体、u1-32抗体、u1-33抗体、u1-34抗体、u1-35抗体、u1-36抗体、u1-37抗体、u1-38抗体、u1-39抗体、u1-40抗体、u1-41抗体、u1-42抗体、u1-43抗体、u1-44抗体、u1-45抗体、u1-46抗体、u1-47抗体、u1-48抗体、u1-49抗体、u1-50抗体、u1-51抗体、u1-52抗体、u1-53抗体、u1-55.1抗体、u1-55抗体、u1-57.1抗体、u1-57抗体、u1-58抗体、u1-59抗体、u1-61.1抗体、u1-61抗体、u1-62抗体或具有所述抗体的至少一条重链或轻链的抗体。特别优选的是抗体u1-49(seqidno.42/44)、u1-53(seqidno:54/56)和u1-59(seqidno:70/72)或具有所述抗体的至少一条重链或轻链的抗体。抗体u1-59是特别优选的。
根据本发明待治疗的疾病是过度增生性疾病。这种过度增生性疾病优选地是癌症，尤其鳞状细胞癌。
优选地根据本发明治疗的癌症的例子选自乳腺癌、胃肠道癌、胰癌症、前列腺癌、卵巢癌、胃癌、子宫内膜癌、唾液腺癌、肺癌、肾癌、结肠癌、结直肠癌、甲状腺癌、膀胱癌、胶质瘤、黑色素瘤、睾丸癌、软组织肉瘤、头颈癌、表达或过量表达her-3的其他癌症和肿瘤转移形成。
根据一个特别优选的实施方案，癌症是肺部、头部和/或颈部的鳞状细胞癌。
本发明的放射治疗优选地选自热疗法、外束放射疗法、近距离放射疗法和/或放射性同位素疗法。本领域技术人员可以决定何种放射治疗并且特别地决定哪个种类的将用于特定待治疗患者的辐射源。
外束放射疗法是最常见形式的放疗法。与内部放疗法(近距离放射疗法)相反，外束放射疗法从身体外部将辐射指向肿瘤。待使用的电压可以由本领域技术人员决定并且尤其取决于待治疗肿瘤的种类。例如，千伏x射线可以用于治疗皮肤癌和浅表结构，而兆伏x射线可以用于治疗位于深部的肿瘤(例如，前列腺、肺或脑肿瘤)。尽管x射线和电子束是迄今最广泛使用的外束放射疗法源，不过还可以使用更重的粒子束如质子束。
如上文已经概述，近距离放射疗法又称作内部放疗法。它是放疗法的一种形式，其中将辐射源置于需要治疗的区域内或与之毗邻。在近距离放射疗法中，将辐射源精确地直接放置在癌性肿瘤的旁侧。这意味着辐射仅影响有限局部区域，这提供胜过x射线束放射疗法的优点。例如，可以用极高剂量的局限化辐射处理肿瘤，同时降低不必要损伤周围健康组织的概率。用于近距离放射疗法的辐射源的例子包括125i/103pd、90y以及选择性内部放射疗法(sirt)。sirt包括使用微球，可能例如注射所述微球。这类种微球可以由树脂或玻璃制成。在微球内部可以安置辐射源如钇-90。已经使用的微球的例子是theresphere和sir-球状体，它们在每个球状体的放射性活度和栓塞效应方面差异。当然，还构思使用与辐射源连接的任何其他适宜载体。近距离放射疗法中使用的药物的其他例子包括savi、mammosite、contura、proxcelan和l-seed。
放射性同位素疗法代表又一种形式的靶向疗法。靶向作用可以归因于同位素的化学特性。放射性同位素可以例如通过输注或摄入来递送。用于治疗的放射性同位素的例子包括碘-131、镥-177和钇-90、锶-89和钐-153。
可以根据本发明使用的放射治疗和/或放射疗法可以基于单次剂量或分次剂量的辐射。当然，还可能变动放射疗法的持续时间。持续时间可以取决于待治疗肿瘤的位置、待治疗肿瘤的尺寸和患者的身体状况。
本发明的her-3抑制剂和放射疗法和/或治疗的组合构思同时用her-3抑制剂和放射疗法以及适时变换的组合治疗。根据一个优选实施方案，在放射治疗之前通过her-3抑制剂使待治疗的肿瘤细胞放射敏感，即在放射治疗/疗法之前施用her-3抑制剂。
本发明可以与又一种活性化合物如又一种化疗化合物如细胞毒药物如多柔比星、顺铂或卡铂、细胞因子或抗肿瘤药组合使用。
本发明的另一个方面涉及her-3的抑制剂用于调节细胞的放射敏感性的用途。
附图简述
图1：
(a)多个癌细胞系中的her3概况。
在相关培养基中培养5个人肺癌细胞系(nci-h226、h292、h358、h520和a549)、5个结直肠癌细胞系(caco2、sw48、ls180、lovo和hct116)和5个头颈癌细胞系(scc1、scc6、scc11a、scc38和scc1483)。用裂解缓冲液获得完整细胞裂解物。使用bradford法将蛋白质定量，通过sds凝胶分离并随后用所示的抗体免疫印迹。
(b)her3的基础活性被u1-59阻断。
具有高p-her3的4个头颈癌细胞系(scc6、scc11a、scc38、scc1483)和两个肺癌细胞系(h226和a549)用u1-59的剂量处理24小时。分离完整细胞裂解物并随后用所示的抗体免疫印迹。u1-59以剂量依赖性方式抑制这些细胞中的her3活性和其下游信号。
图2：
辐射诱导的her3激活被u1-59阻断。(a，d)her3在所示的时间期间被辐射短暂激活并被u1-59阻断。在辐射之前，将scc6和h226细胞与或不与u1-59(20μg/ml)一起温育24小时。在暴露于4gy辐射后，将完整细胞裂解物在所示的时间分离，随后用p-her、p-akt和p-mapk抗体免疫印迹。(b，e)u1-59在辐射后24小时和48小时依旧阻断akt和mapk的激活。(c，f)在scc6和h226细胞中显示her3的免疫荧光由辐射激活并且被u1-59阻断(辐射后30分钟)。
图3.
(a，f)u1-59以剂量依赖性方式抑制细胞增殖。
将scc6和h226细胞接种在96孔板中并且与多个剂量的u1-59温育72小时。使用cck8检测细胞增殖72小时。
(b，g)u1-59对scc6细胞响应于辐射的致敏效应。
将scc6和h226与u1-59温育4小时，并用所示的剂量照射。克隆测定法如所述那样进行。对照曲线在无u1-59处理的情况下暴露于辐射。
(c，h)u1-59对细胞周期的影响。
将scc6和h226细胞与u1-59(20μg/ml)温育48小时，随后暴露于6gy辐射。在辐射后24小时，使用流式细胞仪检测细胞周期(用pi染色)并通过flowjo分析。u1-59造成g1停滞并且辐射造成g2停滞。u1-59和辐射的组合使处于细胞周期内的细胞重配，引起处于g1和g2的细胞积累，并减少处于s期的细胞群体
(d，i)u1-59对细胞凋亡的影响。
使用流式细胞仪检测并通过flowjo分析凋亡(用膜联蛋白v/pi染色)。u1-59与辐射的组合增加凋亡细胞的百分数。
(e，j)u1-59有助于γ-h2ax灶形成。
scc6和h226在4gy辐射之前与u1-59温育24小时。在辐射后4小时，将细胞固定并进行免疫荧光染色。与单独的药物或辐射相比，在采用与u1-59组合的xrt处理的细胞中检测到增加数目的γ-h2ax灶，展示由u1-59所致的增强的dna损伤。
图4.
与辐射组合的u1-59对无胸腺小鼠中异体移植肿瘤的抗肿瘤作用。scc6、scc1483和h226异体移植如“材料和方法”中所述进行。(a)小鼠用单次剂量的igg、辐射(10gy或16gy)、u1-59(8mg/kg)或二者组合处理。数据点表述为平均肿瘤尺寸±sd。结果图示为肿瘤生长曲线和kaplanmeir存活曲线。(b)小鼠用分次剂量的igg、辐射、u1-59(100μg/小鼠)或二者组合一周2次如所示那样处理。结果图示为肿瘤生长曲线和kaplanmeir存活曲线。
图5.
u1-59抑制异体移植肿瘤中her3的基础激活和辐射诱导的激活。在辐射后或在分次处理组中末次辐射后24小时收集scc6、scc1483和h226异体移植肿瘤。从肿瘤分离蛋白质并且通过蛋白质印迹法分析p-her3。照射过的肿瘤中存在增加的p-her3并且用u1-59处理或联合处理过的肿瘤中存在减少的p-her3。
图6.
u1-59抑制细胞存活信号并且与辐射组合时增强对无胸腺小鼠中的异体移植肿瘤上的dna损伤。单次剂量辐射处理(16gy)、u1-59(8mg/kg)或二者组合治疗的scc6异体移植肿瘤，处理后24小时收获肿瘤。如“材料和方法”中所述进行ihc染色。在采用u1-59或联合治疗的肿瘤中检测到减少的p-mapk、p-s6和pcna染色、减少的pcna阳性细胞和增加的γ-h2ax阳性细胞。
实施例
材料和方法
细胞培养物和药物
5个人肺癌细胞系(nci-h226、h292、h358、h520和a549)以及5个结直肠癌细胞系(caco2、sw48、ls180、lovo和hct116)从atcc(马纳萨斯，va，美国)购买并且维持在含有10％胎牛血清(fbs)的含有1％青霉素和链霉素rpmi1640或dmem(mediatechinc.，马纳萨斯，va，美国)中。5个头颈癌细胞系(um-scc1，um-scc4，um-scc6，um-scc11a，和um-scc1483细胞)从密歇根大学获得并且维持在含有10％胎牛血清(fbs)的补充有1％氢化可的松的dmed(invitrogen，carlsbad，ca，美国)中。
使用抗her-3抗体u1-59。
细胞增殖测定法
将细胞接种在96孔板中并且暴露于多个剂量的u1-59持续72小时。通过细胞计数试剂盒-8(dojindomoleculartechnologies,gaithersbury,md，美国)检验细胞增殖。
克隆生成测定法
将指定数目的细胞接种至六孔组织培养平板的每个孔中。在允许细胞贴壁时间(6小时)后，将u1-59或溶媒对照(pbs)以指定的浓度添加。接种后10至14日，将平板随后以剂量2、4、6、8gy照射4小时，集落用结晶紫染色，确定含有至少50个细胞的集落的数目并计算存活分数。针对u1-59单独产生的细胞毒性归一化后，产生存活曲线。展示的数据是来自至少三次独立实验的均数±sd。
细胞周期分析
将细胞与u1-59(20μg/ml)温育48小时，随后6gy辐射。在24小时后，将细胞经胰蛋白酶消化并用pbs洗涤，在90％乙醇中固定并在4℃贮存过夜。通过离心移除乙醇后，将细胞用pi染液缓冲剂(50μg/mlpi，100μg/mlrna酶a，0.1％tritonx-100)染色。通过facscalibur流式细胞仪(bdbiosciences，sanjose，ca，美国)分选细胞。用flowjo软件(treestarinc.，ashland，or，美国)进行方图分析。
凋亡
使用膜联蛋白v/pi试剂盒检测凋亡。在处理后，将100μl染色缓冲液中含有1x105个细胞的细胞悬液与5μl膜联蛋白v和pi温育。通过facscalibur流式细胞仪(bdbiosciences，sanjose，ca，美国)分选细胞。用flowjo软件进行群体分析。
免疫印迹法分析
在处理后，将细胞用缓冲液(50mmhepes，ph7.4，150mmnacl，0.1％tween-20，10％甘油，2.5mmegta，1mmedta，1mmdtt，1mmpmsf和10μg/ml亮肽素和抑蛋白酶肽)裂解。使用标准bradford吸光度测定法定量蛋白质。通过sds-page分离等量的蛋白质。此后，将蛋白质转移至pvdf膜并通过与适宜的第一抗体温育进行分析。通过与hrp缀合的第二抗体温育及ecl化学发光检测系统检测蛋白质。使用nihimagej程序来测量蛋白质印迹条带的光密度。这项研究中使用的抗体如下：her3、akt、mapk、辣根过氧化物酶缀合的山羊抗兔igg和山羊抗小鼠igg从santacruzbiotechnologyinc.(santacruz，ca，美国)购买。p-her3(tyr1289)、p-akt和p-mapk从cellsignalingtechnology(beverly，ma，美国)获得，α-微管蛋白来自calbiochem(sandiego，ca，美国)。
免疫荧光测定法
将大约2x103个细胞接种在4孔玻璃腔式载玻片(nalgenenunc，naperville，il，美国)上。48小时后，将细胞用pbs洗涤3次并用2％甲醛固定在室温15分钟。将细胞在冰冷的100％甲醇中在-20℃温育10分钟并用含有0.3％tritonx100的pbs溶液中的5％正常血清在室温封闭1小时并且与p-her3或λ-h2ax抗体在4℃温育过夜。接下来，将细胞与含有0.3％tritonx100和1％bsa的pbs中fitc缀合的适宜第二抗体温育2小时。使用带dapi的prolong金(invitrogen)封装盖玻片。通过共聚焦显微术或荧光显微术捕获照片。
小鼠异体移植模型
无胸腺裸鼠(4至6周龄；雄性)从harlan实验室(印第安纳波利斯，in，美国)获得。全部动物流程和维护均根据威斯康星大学机构指南实施。将细胞在第0日在小鼠的背腹部双侧注射(2*106个细胞)。一旦肿瘤达到期望体积，将小鼠用1)igg、2)u1-59、3)辐射或4)组合单次剂量处理或分次剂量处理。通过数字式卡尺评价量值并且由式(π)/6x(大直径)x(小直径)计算。
免疫组织化学
异体移植肿瘤固定在中性福尔马林中并包埋在石蜡中。
针对pcna、p-mapk、p-akt、p-s6和γ-h2ax进行免疫组织化学染色。简言之，将标本常规地脱石蜡并复水，随后在水浴中通过柠檬酸盐缓冲液在98℃修复抗原15分钟，在3％过氧化氢中温育10分钟，3％bsa封闭30分钟。如下进行染色：在4℃在稀释于推荐的抗体稀释剂中的第一抗体中温育过夜，在室温在生物素酰化的第二抗体中温育30分钟，使用dakocytomation液dab+底物生色原系统进行过氧化物酶可视化，在苏木精中复染，例行脱水和清洁，用盖玻片封装。
统计分析
将异体移植肿瘤生长作图并使用graphpadprism5(graphpad，sandiego，ca)分析。
结果
her3在多种实体瘤细胞系中表达
人表皮生长因子受体3(her3)是her家族的关键二聚化配偶物并激活致瘤信号传导途径。它在许多实体瘤中的过量表达已经与不良预后相关。在图1a中，我们对源自非小细胞肺癌(h226、h292、h358、h520和a549)、结直肠癌(caco2、sw48、ls180、lovo和hct116)和头颈鳞状细胞癌(scc1、scc6、scc11a、scc38和scc1483)的15个细胞系表征her3和p-her3的表达。hnscc细胞系和nsclc细胞系均含有激活型her3，表明her3可能正在增强它们的致肿瘤表型。
u1-59可以抑制her3的基础活性和辐射诱导的her3激活
her3缺少内在酪氨酸激酶活性。然而，与多个配体，如heregulin(神经调节蛋白-1)结合时，her3可以与其他her家族成员受体形成异二聚体以启动强烈影响细胞增殖和存活的多条信号传导途径的激活。u1-59是与her3结合并失活her3致瘤信号传导途径的全人单克隆抗体。在图1b中，我们显示用递增剂量的u1-59处理多个hnscc和nsclc细胞系可以成功地抑制her3和akt的激活(图1b)。此外，使用免疫印迹法和免疫荧光测定法，我们发现对hnscc细胞系scc6和nsclc细胞系h226的放射处理增加激活形式的her3(图2a、2c、2d和2f)。辐射治疗后her3的短暂激活还伴随scc6和h226细胞系中erk和akt二者激活的增加(图2a和图2d)。在图2b和2e中，我们显示辐射可以导致scc6和h226细胞系中在放射处理24小时和48小时后her3、akt和erk的持续激活。我们随后显示，在放射处理前scc6或h226细胞系与u1-59预温育24小时可能阻止辐射诱导的her3、erk和akt激活(图2a、2c、2d和2f)。另外，u1-59可能导致在放射处理后24小时和48小时her3、erk和akt活化的持续抑制(图2b和图2e)。总体上，这些数据表明在放射处理前细胞与u1-59的预温育可以阻止辐射诱导的细胞存活和增殖途径激活。
u1-59可以在体外辐射致敏hnscc和nsclc细胞系
在图2中，我们展示u1-59可以阻止辐射诱导的her3及后续下游效应器erk和akt激活，因此，我们假设u1-59可增强hnscc细胞系和nsclc细胞系的放射敏感性。首先，我们在图3a和图3f中展示u1-59可以按剂量依赖性方式抑制scc6细胞系和h226细胞系的生长。为了评价与辐射组合的u1-59的体外作用，我们实施如“材料和方法”中所述的克隆生成测定法。我们将scc6和h226细胞与u1-59预温育4小时，随后使细胞接受用所示的剂量辐射。如图3b和3g中所示，u1-59增加辐射曲线的斜率，展示u1-59对scc6和h226细胞响应于辐射的致敏作用。对照曲线在无u1-59处理的情况下暴露于辐射。
u1-59可以在体外与放射治疗组合时促进细胞周期停滞和凋亡
我们进一步假设u1-59还可以增强hnscc和nsclc细胞系对辐射诱导的细胞周期停滞和凋亡。为了研究这一点，我们将scc6和h226细胞与u1-59预温育48小时，随后暴露于6gy辐射。辐射后24小时，我们通过pi和膜联蛋白v染色法分析细胞周期时相分布水平和凋亡水平。如图3c和图3h中所示，与对照细胞相比，u1-59预处理的细胞展示g1相停滞，而辐射处理的细胞展示g2相停滞。我们观察s-相随任一种处理而减少。众所周知，处于g1相的细胞对放射治疗更敏感，而s-相细胞更有抵抗性。因此我们通过膜联蛋白v染色法展示，在辐射处理的与u1-59预温育的细胞中凋亡确实增强(图3d和图3i)，显示由u1-59诱导的g1相停滞可以促进scc6和h226二者的放射敏感性。此外，通过y-h2ax染色，我们进一步在辐射之前用u1-59预处理的scc6和h226细胞中显示增强的dna双链断口水平(图3e和图3j)。总之，这些数据显示与辐射组合的u1-59的增强的抗肿瘤作用。
与辐射组合的u1-59可以在hnscc和nsclc小鼠肿瘤异体移植物中具有抗肿瘤作用
为了进一步评价与u1-59组合的放疗法的功效，我们将scc6、scc1483和h226细胞系接种至无胸腺小鼠中。一旦肿瘤达到100-200mm3，将肿瘤分割用于单次剂量和分次剂量的辐射。在单剂量处理组中，向异体移植小鼠施用igg、u1-59(8mg/kg)，辐射(xrt16gy或xrt10gy)或二者的组合(图4a)。在分次处理组中，向异体移植小鼠施用igg、u1-59(100μg/小鼠)、辐射(按所示剂量一周2次)或组合(图4b)。全部三种异体移植模型均展示与单一疗法治疗的小鼠或igg对照治疗的小鼠相比，用与单次剂量辐射或分次剂量辐射组合的u1-59治疗时，肿瘤体积明显减小。另外，用u1-59和单次剂量辐射或分次剂量辐射治疗的异体移植物展示出清晰的存活优势，如通过kaplanmeir存活曲线分析所述。
为了验证u1-59可能有效地在体内抑制激活her3，我们从源自每个处理组的各种肿瘤中分离蛋白质并对总her3和激活形式的her3进行蛋白质印迹分析。在图5a中，我们显示，从用u1-59单独处理或与单次剂量辐射组合的u1-59处理的小鼠分离的肿瘤具有较低水平的her3激活。在scc1483和h226异体移植模型中，u1-59处理的肿瘤还含有较低的her3蛋白总量(图5a)，这在用u1-59体外处理的这些细胞系中没有观察到。另外，当给予单次剂量辐射时，从5a图中每个异体移植模型分离的两种肿瘤的至少一者显示明显的her3活化，所述her3活化在u1-59处理的肿瘤中被阻断。在图5b中，我们进一步显示与分次剂量辐射组合的u1-59处理的肿瘤还含有减少的激活型her3水平和her3总水平；u1-59还阻断her3被分次剂量辐射激活。总体上，与对照或任一种单独处理相比，采用与单剂量辐射或分次剂量辐射组合的u1-59处理的异体移植肿瘤均显示明显的生长延迟，同时肿瘤体积明显减小，显示激活型her3表达水平和总her3表达水平的损失均可以辐射致敏hnscc和nsclc肿瘤。
与辐射组合的u1-59可以在体内阻止细胞存活信号的激活并增强dna损伤
为了进一步分析与放射处理组合的u1-59的生长抑制作用，我们通过免疫组织化学分析scc6处理的肿瘤中erk、akt、s6激酶和γ-h2ax的激活(图6)。我们显示，用u1-59和单次剂量辐射处理的scc6细胞可以具有下游效应器分子erk、akt和s6激酶的较低激活水平。另外，u1-59处理的肿瘤展示减少的pcna阳性细胞水平。最后，用u1-59和辐射二者处理的scc6肿瘤中存在增加的γ-h2ax水平。总体，这些数据表明除增强dna损伤之外，与辐射组合的u1-59可以有效地抑制细胞存活和增殖途径。这些数据为与辐射组合的u1-59的增强的体内抗肿瘤作用提供机理性证据。
这些实验的结果表明，u1-59和辐射的组合在使用单次剂量辐射或分次剂量辐射的研究中对肿瘤生长具有强烈影响。肿瘤分析表明体内放射治疗激活的her3和u1-59能够消除这种激活。总之，我们的体外和体内研究结果表明，通过延迟细胞周期进展、增加凋亡和增加dna损伤，与辐射组合的u1-59对细胞和肿瘤生长具有影响。这些研究结果表明her3可以在响应于放射疗法时发挥重要作用，并且阻断其活性可能在人肿瘤中具有强的治疗益处。cdr序列表
序列表
<110>u3制药有限公司
<120>用于调节放射敏感性的her3抑制剂
<130>53017pus
<140>
<141>
<150>
<151>
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gactccgtgaagggccgattcaccatctccagagacaattccaagaacacgctgtatctt240
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202530
tyrmetsertrpvalargglnalaproglylysglyleuasptrpval
354045
servaliletyrserglyglyserthrtyrtyralaaspservallys
505560
glyargphethrileserargaspasnserlysasnthrleutyrleu
65707580
glnmetasnserleuargalagluaspthralavaltyrtyrcysala
859095
argglyglntrpleuaspvaltrpglyglnglythrthrvalthrval
100105110
serser
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tacctgcagaggccagggcagtctccacaactcctgttctatttgggttttcatcgggcc180
tccggggtccctgacaggttcagtggcagtggatcaggcacagattttacactgaaaatc240
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202530
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354045
proglnleuleuphetyrleuglyphehisargalaserglyvalpro
505560
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65707580
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cagcacccagggaagggcctggagtggattgggtacatctattccagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagat300
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glnvalglnleuglngluserglyproglyleuvallysprosergln
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thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrserserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
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tacctgcagaagccagggcagtctccacagctcctgatctatttgggttctaatcgggcc180
tccggggtccctgacaggttcagtggcagtggatcaggcacagattttacactgaaaatc240
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aspilevalmetthrglnserproleuserleuprovalthrprogly
151015
gluproalaserilesercysargserserglnserleuleutyrser
202530
asnglytyrasntyrleuasptrptyrleuglnlysproglyglnser
354045
proglnleuleuiletyrleuglyserasnargalaserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyiletyrtyrcysmetglnala
859095
leuglnthrproleuthrpheglyglyglythrlysvalgluilelys
100105110
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cagcccccaggaaaggccctggactggcttgcactcatttattggaatgatgataagcgc180
tacagcccatctctgaagagcaggctcaccatcaccaaggacacctccaaaaaccaggtg240
gtccttacaatgaccaacatggatcttgtggacacagccacatattactgtgtacacaga300
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glnilethrleulysgluserglyprothrleuvallysprothrgln
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202530
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354045
trpleualaleuiletyrtrpasnaspasplysargtyrserproser
505560
leulysserargleuthrilethrlysaspthrserlysasnglnval
65707580
valleuthrmetthrasnmetaspleuvalaspthralathrtyrtyr
859095
cysvalhisargaspgluvalargglypheasptyrtrpglyglngly
100105110
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115
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tttcagcagaggccaggccaatctccaaggcgccttatttataaggtttctaactgggac180
tctggggtcccagacagattcagcggcagtgggtcaggcactgatttcacactgaaaatc240
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<223>antibody
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aspvalvalmetthrglnserproleuserleuprovalthrleugly
151015
glnproalaserilesercysargserserglnserleuvaltyrser
202530
aspglytyrthrtyrleuhistrppheglnglnargproglyglnser
354045
proargargleuiletyrlysvalserasntrpaspserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglngly
859095
alahistrpproilethrpheglyglnglythrargleugluilelys
100105110
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caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
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cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtatttctgtgcgagagat300
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gtcaccgtctcctc374
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glnvalglnleuglngluserglyproglyleuvallysprosergln
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thrleuserleuthrcysthrvalserglyglyserilesersergly
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glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrphe
859095
cysalaargasparggluleugluglytyrserasntyrtyrglyval
100105110
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gggaaagcccctaagctcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagcagcctgcagcct240
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<223>antibody
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aspileglnmetthrglnserproserserleuseralaservalgly
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leuasntrptyrglnglnlysproglylysalaprolysleuleuile
354045
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serglyserglythraspphethrleuthrileserserleuglnpro
65707580
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859095
thrpheglyglnglythrargleugluilelys
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<223>antibody
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cccgggaaaggcctggagtggatggggatcatctatcctggtgactctgataccagatac180
agcccgtccttccaaggccaggtcaccatctcagccgacaagtccatcagcaccgcctac240
ctgcagtggagcagcctgaaggcctcggacaccgccatgtattactgtgcgagacatgaa300
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gluvalglnleuvalglnserglyalagluvallyslysproglyglu
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serleulysilesercyslysglyserglytyrserphethrsertyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspseraspthrargtyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileserthralatyr
65707580
leuglntrpserserleulysalaseraspthralamettyrtyrcys
859095
alaarghisgluasntyrglyasptyrasntyrtrpglyglnglythr
100105110
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115
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gggaaagcccctaagctcctgatctatgctgcttccagtttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct240
gaagattttgcactttactgctgtcaacagagtaacggttccccgctcactttcggcgga300
gggaccaaggtggagatcaaa321
<210>20
<211>107
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aspileglnmetthrglnserproserserleuseralaservalgly
151015
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202530
leuasntrptyrglnglnlysproglylysalaprolysleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealaleutyrcyscysglnglnserasnglyserproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
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caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
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cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaggagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagat300
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accacggtcaccgtctcctc380
<210>22
<211>126
<212>prt
<213>artificial
<220>
<223>antibody
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glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leuargserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargasparggluargglutrpaspasptyrglyaspprogln
100105110
glymetaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>23
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gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
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gggaaagcccctaagctcctgatccatgctgcatccagtttacaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagtagtctgcaacct240
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gggaccaaggtggagatccaa321
<210>24
<211>107
<212>prt
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<220>
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aspileglnmetthrglnserproserserleuseralaservalgly
151015
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202530
leuhistrptyrglnglnlysproglylysalaprolysleuleuile
354045
hisalaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserasnproleu
859095
thrpheglyglyglythrlysvalgluilegln
100105
<210>25
<211>354
<212>dna
<213>artificial
<220>
<223>antibody
<400>25
gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatc60
tcctgtaagggttctggatacagctttaccagctactggatcggctgggtgcgccagatg120
cccgggaaaggcctggagtggatggggatcatctggcctggtgactctgataccatatac180
agcccgtccttccaaggccaggtcaccatctcagccgacaagtccatcagcaccgcctac240
ctgcagtggagcagcctgaaggcctcggacaccgccatgtattactgtgcgagacatgaa300
aactacggtgactacaactactggggccagggaaccctggtcaccgtctcctca354
<210>26
<211>118
<212>prt
<213>artificial
<220>
<223>antibody
<400>26
gluvalglnleuvalglnserglyalagluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrserphethrsertyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletrpproglyaspseraspthriletyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileserthralatyr
65707580
leuglntrpserserleulysalaseraspthralamettyrtyrcys
859095
alaarghisgluasntyrglyasptyrasntyrtrpglyglnglythr
100105110
leuvalthrvalserser
115
<210>27
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>27
gacatccagatgacccagtctccatcctccctgtctgcatctgtgggagacagagtcacc60
atcacttgccgggcaagtcagagcattcgaagttatttaaattggtatcagcagaaaccg120
gggaatgcccctaaactcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct240
gaagattttgcactttactactgtcaacagagtatcagttccccgctcactttcggcgga300
gggaccaaggtggagatcaaa321
<210>28
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>28
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserileargsertyr
202530
leuasntrptyrglnglnlysproglyasnalaprolysleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealaleutyrtyrcysglnglnserileserserproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
<210>29
<211>374
<212>dna
<213>artificial
<220>
<223>antibody
<400>29
caggtgcagctggtgcagtctggggctgaggtgaagaagcctggggcctcagtgaaggtc60
tcctgcaaggcttctggatacaccttcaccagttatgatatcaactgggtgcgacaggcc120
actggacaagggcttgagtggatgggatggatgaaccctaacagtggtgacactggctat180
gcacaggtgttccagggcagagtcaccatgacctggaacacctccataagcacagcctac240
atggaactgagcagcctgagatctgaggacacggccgtgtattactgtgcgagatttggg300
gatctcccgtatgactacagttactacgaatggttcgacccctggggccagggaaccctg360
gtcaccgtctcctc374
<210>30
<211>124
<212>prt
<213>artificial
<220>
<223>antibody
<400>30
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysalaserglytyrthrphethrsertyr
202530
aspileasntrpvalargglnalathrglyglnglyleuglutrpmet
354045
glytrpmetasnproasnserglyaspthrglytyralaglnvalphe
505560
glnglyargvalthrmetthrtrpasnthrserileserthralatyr
65707580
metgluleuserserleuargsergluaspthralavaltyrtyrcys
859095
alaargpheglyaspleuprotyrasptyrsertyrtyrglutrpphe
100105110
aspprotrpglyglnglythrleuvalthrvalser
115120
<210>31
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>31
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagccagagcattagcagctatttaaattggtatcagcagagacca120
gggaaagcccctaagctcctgatctatgcagcatccagtttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacagtaccccgctcactttcggcgga300
gggaccaaggtggagatcaaa321
<210>32
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>32
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserilesersertyr
202530
leuasntrptyrglnglnargproglylysalaprolysleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserthrproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
<210>33
<211>386
<212>dna
<213>artificial
<220>
<223>antibody
<400>33
caggtacagctgcagcagtcaggtccaggactggtgaagccctcgcagaccctctcactc60
acctgtgccatctccggggacagtgtctctagcaacagtgctgcttggaactggatcagg120
cagtccccatcgagaggccttgagtggctgggaaggacatactacaggtccaagtggtat180
aatgattatgcagtatctgtgaaaagtcgaataaccatcaacccagacacatccaagaac240
cagttctccctgcagctgaactctgtgactcccgaggacacggctgtgtattactgtgca300
agagatctctacgatttttggagtggttatccctactactacggtatggacgtctggggc360
caagggaccacggtcaccgtctcctc386
<210>34
<211>128
<212>prt
<213>artificial
<220>
<223>antibody
<400>34
glnvalglnleuglnglnserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysalaileserglyaspservalserserasn
202530
seralaalatrpasntrpileargglnserproserargglyleuglu
354045
trpleuglyargthrtyrtyrargserlystrptyrasnasptyrala
505560
valservallysserargilethrileasnproaspthrserlysasn
65707580
glnpheserleuglnleuasnservalthrprogluaspthralaval
859095
tyrtyrcysalaargaspleutyraspphetrpserglytyrprotyr
100105110
tyrtyrglymetaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>35
<211>383
<212>dna
<213>artificial
<220>
<223>antibody
<400>35
caggtacagctgcagcagtcaggtccaggactggtgaagccctcgcagaccctctcactc60
acctgtgccatctccggggacagtgtctctagcaacagtgctgcttggaactggatcagg120
cagtccccatcgagaggccttgagtggctgggaaggacatactacaggtccaagtggtat180
aatgattatgcagtatctgtgaaaagtcgaataaccatcaacccagacacatccaagaac240
cagttctccctgcagctgaactctgtgactcccgaggacacggctgtgtattactgtgca300
agagattactatggttcggggagtttctactactactacggtatggacgtctggggccaa360
gggaccacggtcaccgtctcctc383
<210>36
<211>127
<212>prt
<213>artificial
<220>
<223>antibody
<400>36
glnvalglnleuglnglnserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysalaileserglyaspservalserserasn
202530
seralaalatrpasntrpileargglnserproserargglyleuglu
354045
trpleuglyargthrtyrtyrargserlystrptyrasnasptyrala
505560
valservallysserargilethrileasnproaspthrserlysasn
65707580
glnpheserleuglnleuasnservalthrprogluaspthralaval
859095
tyrtyrcysalaargasptyrtyrglyserglyserphetyrtyrtyr
100105110
tyrglymetaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>37
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>37
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagagcattagcagctatttaaattggtatcagcagaaacca120
gggaaagcccctaaggtcctgatctatgctgcatccaatttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacagtacccctcggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>38
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>38
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserilesersertyr
202530
leuasntrptyrglnglnlysproglylysalaprolysvalleuile
354045
tyralaalaserasnleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserthrproarg
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>39
<211>371
<212>dna
<213>artificial
<220>
<223>antibody
<400>39
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctc60
acctgcactgtctctggtggctccatcagtagttactactggagctggatccggcagccc120
gccgggaagggactggagtggattgggcatatctataccagtgggagcaccaactacaac180
ccctccctcaagagtcgagtcaccatgtcagtagacacgtccaagaaccagttctccctg240
aagctgagctctgtgaccgccgcggacacggccgtgtattactgtgcgagagaagcgatt300
tttggagtgggcccctactactactacggtatggacgtctggggccaagggaccacggtc360
accgtctcctc371
<210>40
<211>123
<212>prt
<213>artificial
<220>
<223>antibody
<400>40
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyserilesersertyr
202530
tyrtrpsertrpileargglnproalaglylysglyleuglutrpile
354045
glyhisiletyrthrserglyserthrasntyrasnproserleulys
505560
serargvalthrmetservalaspthrserlysasnglnpheserleu
65707580
lysleuserservalthralaalaaspthralavaltyrtyrcysala
859095
argglualailepheglyvalglyprotyrtyrtyrtyrglymetasp
100105110
valtrpglyglnglythrthrvalthrvalser
115120
<210>41
<211>377
<212>dna
<213>artificial
<220>
<223>antibody
<400>41
caggtgcagctggtgcagtctggggctgaggtgaagaagcctggggcctcagtgaaggtc60
tcctgcaaggcttctggatacaccttcaccggctactatatgcactgggtgcgacaggcc120
cctggacaagggcttgagtggatgggatggatcaaccctaatattggtggcacaaactgt180
gcacagaagtttcagggcagggtcaccatgaccagggacacgtccatcagcacagcctac240
atggagctgagcaggctgagatctgacgacacggccgtgtattactgtgcgagaggggga300
cggtatagcagcagctggtcctactactactacggtatggacgtctggggccaagggacc360
acggtcaccgtctcctc377
<210>42
<211>125
<212>prt
<213>artificial
<220>
<223>antibody
<400>42
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysalaserglytyrthrphethrglytyr
202530
tyrmethistrpvalargglnalaproglyglnglyleuglutrpmet
354045
glytrpileasnproasnileglyglythrasncysalaglnlysphe
505560
glnglyargvalthrmetthrargaspthrserileserthralatyr
65707580
metgluleuserargleuargseraspaspthralavaltyrtyrcys
859095
alaargglyglyargtyrsersersertrpsertyrtyrtyrtyrgly
100105110
metaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>43
<211>336
<212>dna
<213>artificial
<220>
<223>antibody
<400>43
gatattctgatgacccagactccactctctctgtccgtcacccctggacagccggcctcc60
atctcctgcaagtctagtcagagcctcctgcttagtgatggagggacctatttgtattgg120
tacctgcagaagccaggccagcctccacagctcctgatctatgaagtttccaaccggttc180
tctggagtgccagataggttcagtggcagcgggtcagggacagatttcacactgaaaatc240
agccgggtggaggctgaggatgttggggtttattactgcatgcaaagtatgcagcttccg300
atcaccttcggccaagggacacgactggaaattaaa336
<210>44
<211>112
<212>prt
<213>artificial
<220>
<223>antibody
<400>44
aspileleumetthrglnthrproleuserleuservalthrprogly
151015
glnproalaserilesercyslysserserglnserleuleuleuser
202530
aspglyglythrtyrleutyrtrptyrleuglnlysproglyglnpro
354045
proglnleuleuiletyrgluvalserasnargpheserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglnser
859095
metglnleuproilethrpheglyglnglythrargleugluilelys
100105110
<210>45
<211>380
<212>dna
<213>artificial
<220>
<223>antibody
<400>45
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctc60
acctgcactgtctctggtggctccgtcagcagtggtggttactactggagctggatccgg120
cagcccccagggaagggactggagtggattgggtatatctattacagtgggagcaccaac180
tacaacccctccctcaagagtcgagtcaccatatcagtagacacgtccaagaaccagttc240
tccctgaagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagaggg300
ggggacagtaactacgaggattactactactactacggtatggacgtctggggccaaggg360
accacggtcaccgtctcctc380
<210>46
<211>126
<212>prt
<213>artificial
<220>
<223>antibody
<400>46
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyservalsersergly
202530
glytyrtyrtrpsertrpileargglnproproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrasntyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargglyglyaspserasntyrgluasptyrtyrtyrtyrtyr
100105110
glymetaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>47
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>47
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagagcattagcatctatttacattggtatcagcagaaacca120
gggaaagcccctaagctcttgatctctgctgcatccagtttgcaaagtggggtcccgtca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcagaagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacacttccccgatcaccttcggccaa300
gggacacgactggagattaaa321
<210>48
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>48
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserileseriletyr
202530
leuhistrptyrglnglnlysproglylysalaprolysleuleuile
354045
seralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileargserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrthrserproile
859095
thrpheglyglnglythrargleugluilelys
100105
<210>49
<211>380
<212>dna
<213>artificial
<220>
<223>antibody
<400>49
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctc60
acctgcactgtctctggtggctccatcagtagttactactggagctggatccggcagccc120
ccagggaagggactggagtggattgggtatatctattacagtgggagcaccaactacaac180
ccctccctcaagagtcgagtcaccatatcagtagacacgtccaagcaccagttctccctg240
aagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagagattcgagt300
tactatgatagtagtggttattacttatactactacgctatggacgtctggggccaaggg360
accacggtcaccgtctcctc380
<210>50
<211>126
<212>prt
<213>artificial
<220>
<223>antibody
<400>50
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyserilesersertyr
202530
tyrtrpsertrpileargglnproproglylysglyleuglutrpile
354045
glytyriletyrtyrserglyserthrasntyrasnproserleulys
505560
serargvalthrileservalaspthrserlyshisglnpheserleu
65707580
lysleuserservalthralaalaaspthralavaltyrtyrcysala
859095
argaspsersertyrtyraspserserglytyrtyrleutyrtyrtyr
100105110
alametaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>51
<211>339
<212>dna
<213>artificial
<220>
<223>antibody
<400>51
gacatcgtgatgacccagtctccagactccctggctgtgtctctgggcgagagggccacc60
atcaactgcaagtccagccagagtgttttatacagctccaacaataagaactacttagct120
tggtaccagcagaaaccaggacagcctcctaagctgctcatttcctgggcatctacccgg180
gaatccggggtccctgaccgattcagtggcagcgggtctgggacagatttcactctcacc240
atcagcagcctgcaggctgaagatgtggcagtttattactgtcagcaatattatactact300
cctctcactttcggccctgggaccaaagtggatatcaaa339
<210>52
<211>113
<212>prt
<213>artificial
<220>
<223>antibody
<400>52
aspilevalmetthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serasnasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuilesertrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrthrthrproleuthrpheglyproglythrlysvalaspile
100105110
lys
<210>53
<211>357
<212>dna
<213>artificial
<220>
<223>antibody
<400>53
gaggtgcaactggtggagtctgggggaggcttggtacagcctggggggtccctgagactc60
tcctgtgcagcctctggattcaccttcagtatctatagcatgaactgggtccgccaggct120
ccagggaaggggctggagtgggtttcatacattagtagtagtagtagtaccatatactac180
gcagactctgtgaagggccgattcaccatctccagagacaatgccaagaactcactgtat240
ctgcaaatgaacagcctgagagacgaggacacggctgtgtattactgtgcgagagatagg300
ggtgacttcgatgcttttgatatctggggccaagggacaatggtcaccgtctcttca357
<210>54
<211>119
<212>prt
<213>artificial
<220>
<223>antibody
<400>54
gluvalglnleuvalgluserglyglyglyleuvalglnproglygly
151015
serleuargleusercysalaalaserglyphethrpheseriletyr
202530
sermetasntrpvalargglnalaproglylysglyleuglutrpval
354045
sertyrileserserserserserthriletyrtyralaaspserval
505560
lysglyargphethrileserargaspasnalalysasnserleutyr
65707580
leuglnmetasnserleuargaspgluaspthralavaltyrtyrcys
859095
alaargaspargglyasppheaspalapheaspiletrpglyglngly
100105110
thrmetvalthrvalserser
115
<210>55
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>55
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccaggcgagtcaggacattaccaactatttgaattggtatcagcagaaacca120
gggaaagcccctaagctcctgatctacgatgcatccaatttggaaacaggggtcccatca180
aggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcct240
gaagatattgcaacatataactgtcaacagtgtgaaaatttcccgatcaccttcggccaa300
gggacacgactggagattaaa321
<210>56
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>56
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysglnalaserglnaspilethrasntyr
202530
leuasntrptyrglnglnlysproglylysalaprolysleuleuile
354045
tyraspalaserasnleugluthrglyvalproserargphesergly
505560
serglyserglythraspphethrphethrileserserleuglnpro
65707580
gluaspilealathrtyrasncysglnglncysgluasnpheproile
859095
thrpheglyglnglythrargleugluilelys
100105
<210>57
<211>336
<212>dna
<213>artificial
<220>
<223>antibody
<400>57
gatattgtgatgactcagtctccactctccctgcccgtcacccctggagagccggcctcc60
atctcctgcaggtctagtcagagcctcctgtatagtaatggatacaagtatttggattgg120
tacctgcagaagccagggcagtctccacagctcctgatctatttgggttctaatcgggcc180
tccggggtccctgacaggttcagtggcagtggatcaggcacagattttacactgaaaatc240
agcagagtggaggctgaggatgttggggtttattattgcatgcaggctctacaaactccg300
atcaccttcggccaagggacacgactggagattaaa336
<210>58
<211>112
<212>prt
<213>artificial
<220>
<223>antibody
<400>58
aspilevalmetthrglnserproleuserleuprovalthrprogly
151015
gluproalaserilesercysargserserglnserleuleutyrser
202530
asnglytyrlystyrleuasptrptyrleuglnlysproglyglnser
354045
proglnleuleuiletyrleuglyserasnargalaserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglnala
859095
leuglnthrproilethrpheglyglnglythrargleugluilelys
100105110
<210>59
<211>374
<212>dna
<213>artificial
<220>
<223>antibody
<400>59
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctc60
acctgcactgtctctggtggctccgtcagcagtggtggttactactggaactggatccgg120
cagcccccagggaagggactggagtggattgggtatatcaattacagtgggagcaccaac180
tacaacccctccctcaagagtcgagtcaccatatcagtagacacgtccaagaaccagttc240
tccctgaagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagagat300
cgagaactggaactttactactactactacggtatggacgtctggggccaagggaccacg360
gtcaccgtctcctc374
<210>60
<211>124
<212>prt
<213>artificial
<220>
<223>antibody
<400>60
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyservalsersergly
202530
glytyrtyrtrpasntrpileargglnproproglylysglyleuglu
354045
trpileglytyrileasntyrserglyserthrasntyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargasparggluleugluleutyrtyrtyrtyrtyrglymet
100105110
aspvaltrpglyglnglythrthrvalthrvalser
115120
<210>61
<211>374
<212>dna
<213>artificial
<220>
<223>antibody
<400>61
caggtgcagctgcaggagtcgggcccaggactggtgaagccttctgagaccctgtccctc60
acctgcactgtctctggtggctccgtcagcagtggtggttactactggaactggatccgg120
cagcccccagggaagggactggagtggattgggtatatcaattacagtgggagcaccaac180
tacaacccctccctcaagagtcgagtcaccatatcagtagacacgtccaagaaccagttc240
tccctgaagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagagat300
cgagaactggaactttactactactactacggtatggacgtctggggccaagggaccacg360
gtcaccgtctcctc374
<210>62
<211>124
<212>prt
<213>artificial
<220>
<223>antibody
<400>62
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyservalsersergly
202530
glytyrtyrtrpasntrpileargglnproproglylysglyleuglu
354045
trpileglytyrileasntyrserglyserthrasntyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargasparggluleugluleutyrtyrtyrtyrtyrglymet
100105110
aspvaltrpglyglnglythrthrvalthrvalser
115120
<210>63
<211>336
<212>dna
<213>artificial
<220>
<223>antibody
<400>63
gatattgtgatgactcagtctccactctccctgcccgtcacccctggagagccggcctcc60
atctcctgcaggtctagtcagagcctcctgtatagtaatggatacaagtatttggattgg120
tacctgcagaagccagggcagtctccacagctcatgatctatttgggttctaatcgggcc180
tccggggtccctgacaggttcagtggcagtggatcaggcacagattttacactgaaaatc240
agcagagtggaggctgaggatgttggggtttattattgcatgcaggctctacaaactccg300
atcaccttcggccaagggacacgactggagattaaa336
<210>64
<211>112
<212>prt
<213>artificial
<220>
<223>antibody
<400>64
aspilevalmetthrglnserproleuserleuprovalthrprogly
151015
gluproalaserilesercysargserserglnserleuleutyrser
202530
asnglytyrlystyrleuasptrptyrleuglnlysproglyglnser
354045
proglnleumetiletyrleuglyserasnargalaserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglnala
859095
leuglnthrproilethrpheglyglnglythrargleugluilelys
100105110
<210>65
<211>363
<212>dna
<213>artificial
<220>
<223>antibody
<400>65
caggtgcagctggtggagtctgggggaggcgtggtccagcctgggaggtccctgagactc60
tcctgtgcagcgtctggattcaccttcagtagctatggcatgcactgggtccgccaggct120
ccaggcaaggggctggagtgggtggcagttatatggtatgatggaagtaataaatactat180
gcagactccgtgaagggccgattcaccatctccagagacaattccaagaacacgctgtat240
ctgcaaatgaacagcctgagagccgaggacacggctgtgtattactgtgcgagagcagct300
cgccttgactactactacggtatggacgtctggggccaagggaccacggtcaccgtctcc360
tca363
<210>66
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>66
glnvalglnleuvalgluserglyglyglyvalvalglnproglyarg
151015
serleuargleusercysalaalaserglyphethrphesersertyr
202530
glymethistrpvalargglnalaproglylysglyleuglutrpval
354045
alavaliletrptyraspglyserasnlystyrtyralaaspserval
505560
lysglyargphethrileserargaspasnserlysasnthrleutyr
65707580
leuglnmetasnserleuargalagluaspthralavaltyrtyrcys
859095
alaargalaalaargleuasptyrtyrtyrglymetaspvaltrpgly
100105110
glnglythrthrvalthrvalserser
115120
<210>67
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>67
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtctcc60
atcacttgccgggcaagtcagagcattaacagctatttaaattggtttcagcagaagcca120
gggaaagcccctcagctcctgatctttggtgcatccggtttgcaaagtggggtcccatca180
aggttcagtggcagtggatctgggacagatttcactctcaccatcaacagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacagttccccgctcaccttcggccaa300
gggacacgactggagattaaa321
<210>68
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>68
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalserilethrcysargalaserglnserileasnsertyr
202530
leuasntrppheglnglnlysproglylysalaproglnleuleuile
354045
pheglyalaserglyleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileasnserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserserproleu
859095
thrpheglyglnglythrargleugluilelys
100105
<210>69
<211>351
<212>dna
<213>artificial
<220>
<223>antibody
<400>69
caggtgcagctacagcagtggggcgcaggactgttgaagccttcggagaccctgtccctc60
acctgcgctgtctatggtgggtccttcagtggttactactggagctggatccgccagccc120
ccagggaaggggctggagtggattggggaaatcaatcatagtggaagcaccaactacaac180
ccgtccctcaagagtcgagtcaccatatcagtagaaacgtccaagaaccagttctccctg240
aagctgagctctgtgaccgccgcggacacggctgtgtattactgtgcgagagataagtgg300
acctggtacttcgatctctggggccgtggcaccctggtcactgtctcctca351
<210>70
<211>117
<212>prt
<213>artificial
<220>
<223>antibody
<400>70
glnvalglnleuglnglntrpglyalaglyleuleulysproserglu
151015
thrleuserleuthrcysalavaltyrglyglyserpheserglytyr
202530
tyrtrpsertrpileargglnproproglylysglyleuglutrpile
354045
glygluileasnhisserglyserthrasntyrasnproserleulys
505560
serargvalthrileservalgluthrserlysasnglnpheserleu
65707580
lysleuserservalthralaalaaspthralavaltyrtyrcysala
859095
argasplystrpthrtrptyrpheaspleutrpglyargglythrleu
100105110
valthrvalserser
115
<210>71
<211>339
<212>dna
<213>artificial
<220>
<223>antibody
<400>71
gacatcgagatgacccagtctccagactccctggctgtgtctctgggcgagagggccacc60
atcaactgcaggtccagccagagtgttttatacagctccagcaataggaactacttagct120
tggtaccagcagaacccaggacagcctcctaagctgctcatttactgggcttctacccgg180
gaatccggggtccctgaccgattcagtggcagcgggtctgggacagatttcactctcacc240
atcagcagcctgcaggctgaagatgtggcagtttattactgtcagcaatattatagtact300
cctcggacgttcggccaagggaccaaggtggaaatcaaa339
<210>72
<211>113
<212>prt
<213>artificial
<220>
<223>antibody
<400>72
aspileglumetthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncysargserserglnservalleutyrser
202530
serserasnargasntyrleualatrptyrglnglnasnproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrproargthrpheglyglnglythrlysvalgluile
100105110
lys
<210>73
<211>374
<212>dna
<213>artificial
<220>
<223>antibody
<400>73
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtggttactactggagctggatccgc120
cagcacccagggaagggcctggagtggatggggaacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctgagaaccagttc240
tccctgaagctgaactctgtgactgccgcggacacggccgtatattactgtgcgagaggg300
ggaactggaaccaattactactactactacggtatggacgtctggggccaagggaccacg360
gtcaccgtctcctc374
<210>74
<211>124
<212>prt
<213>artificial
<220>
<223>antibody
<400>74
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpmetglyasniletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrsergluasnglnphe
65707580
serleulysleuasnservalthralaalaaspthralavaltyrtyr
859095
cysalaargglyglythrglythrasntyrtyrtyrtyrtyrglymet
100105110
aspvaltrpglyglnglythrthrvalthrvalser
115120
<210>75
<211>324
<212>dna
<213>artificial
<220>
<223>antibody
<400>75
gaaattgtgttgacgcagtctccaggcaccctgtctttgtctccaggggaaagagccacc60
ctctcctgcagggccagtcagagtgttagcagcagctacttagcctggtaccagcagaaa120
cctggccaggctcccaggctcctcatctatggtgcatccagctgggccactggcatccca180
aacaggttcagtggcagtgggtctgggacagacttcactctcaccatcagcagactggag240
cctgaagattttgcagtgtattactgtcagcagtatggtagctcaccgctcactttcggc300
ggagggaccaaggtggagatcaaa324
<210>76
<211>108
<212>prt
<213>artificial
<220>
<223>antibody
<400>76
gluilevalleuthrglnserproglythrleuserleuserprogly
151015
gluargalathrleusercysargalaserglnservalserserser
202530
tyrleualatrptyrglnglnlysproglyglnalaproargleuleu
354045
iletyrglyalasersertrpalathrglyileproasnargpheser
505560
glyserglyserglythraspphethrleuthrileserargleuglu
65707580
progluaspphealavaltyrtyrcysglnglntyrglyserserpro
859095
leuthrpheglyglyglythrlysvalgluilelys
100105
<210>77
<211>377
<212>dna
<213>artificial
<220>
<223>antibody
<400>77
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtgtctccatcagcagtggtggttactactggagctggatccgc120
cagcacccagggatgggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagtcaccatatcagaagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagat300
tccgagtccgagtatagcagctcgtcgaactacggtatggacgtctggggccaagggacc360
acggtcaccgtctcctc377
<210>78
<211>125
<212>prt
<213>artificial
<220>
<223>antibody
<400>78
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyvalserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglymetglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrilesergluaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargaspsergluserglutyrserserserserasntyrgly
100105110
metaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>79
<211>377
<212>dna
<213>artificial
<220>
<223>antibody
<400>79
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtgtctccatcagcagtggtggttactactggagctggatccgc120
cagcacccagggatgggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagtcaccatatcagaagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagat300
tccgagtccgagtatagcagctcgtcgaactacggtatggacgtctggggccaagggacc360
acggtcaccgtctcctc377
<210>80
<211>125
<212>prt
<213>artificial
<220>
<223>antibody
<400>80
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyvalserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglymetglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrilesergluaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargaspsergluserglutyrserserserserasntyrgly
100105110
metaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>81
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>81
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagaatcacc60
atcacttgccgggcaagtcagaccattagcagctatttaaattggtatcagcagaaacca120
gggaaagcccctaagctcctgatctatgctgcatccagtttgcaaggtggggtcccatca180
aggttcagtggcagtgtatctgggacagatttcaccctcaccgtcagcagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacagtaacccgctcactttcggcgga300
gggaccaaggtggagatcaaa321
<210>82
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>82
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargilethrilethrcysargalaserglnthrilesersertyr
202530
leuasntrptyrglnglnlysproglylysalaprolysleuleuile
354045
tyralaalaserserleuglnglyglyvalproserargphesergly
505560
servalserglythraspphethrleuthrvalserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserasnproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
<210>83
<211>371
<212>dna
<213>artificial
<220>
<223>antibody
<400>83
gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatc60
tcctgtaagggttctggatacagttttaccagctactggatcggctgggtgcgccagatg120
cccgggaaaggcctggagtggatggggatcatctatcctggtgactctgataccagatac180
agcccgtccttccaaggccaggtcaccatgtcagccgacaagtccatcagtaccgcctac240
ctgcagctgagcagccatgaaggcctcggacaccgccatgtattactgtgcgagacagat300
ggctggaaactacgtacatcacgggtgatcgagacgtcctggggccaagggaccacggtc360
accgtctcctc371
<210>84
<211>123
<212>prt
<213>artificial
<220>
<223>antibody
<400>84
gluvalglnleuvalglnserglyalagluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrserphethrsertyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspseraspthrargtyrserproserphe
505560
glnglyglnvalthrmetseralaasplysserileserthralatyr
65707580
leuglnleuserserhisgluglyleuglyhisarghisvalleuleu
859095
cysgluthraspglytrplysleuargthrserargvalilegluthr
100105110
sertrpglyglnglythrthrvalthrvalser
115120
<210>85
<211>324
<212>dna
<213>artificial
<220>
<223>antibody
<400>85
gaaattgtgttgacgcagtctccaggcaccctgtctttgtctccaggggaaagagccacc60
ctctcctgcagggccagtcagagtgttatcagcatctacttagcctggtaccagcagaaa120
cctggccaggctcccaggctcctcatctatggtgcatccagcagggccactggcatccca180
gacaggttcagtggcagtgggtctgggacagacttcactctcaccatcagcagactggag240
cctgaagattttgcagtgtattactgtcagcagtatggtagctcaccgtgcagttttggc300
caggggaccaaactggagatcaaa324
<210>86
<211>108
<212>prt
<213>artificial
<220>
<223>antibody
<400>86
gluilevalleuthrglnserproglythrleuserleuserprogly
151015
gluargalathrleusercysargalaserglnservalileserile
202530
tyrleualatrptyrglnglnlysproglyglnalaproargleuleu
354045
iletyrglyalaserserargalathrglyileproaspargpheser
505560
glyserglyserglythraspphethrleuthrileserargleuglu
65707580
progluaspphealavaltyrtyrcysglnglntyrglyserserpro
859095
cysserpheglyglnglythrlysleugluilelys
100105
<210>87
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>87
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaggagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>88
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>88
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leuargserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>89
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>89
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagatacct120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcaacagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatggttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>90
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>90
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnileproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileasnserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnglytyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>91
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>91
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattggatacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>92
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>92
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>93
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>93
gacttccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcaggacattcgaaatgatttaggctggtatcggcagaaacct120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>94
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>94
asppheglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnaspileargasnasp
202530
leuglytrptyrargglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>95
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>95
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattggatacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcaatagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggaatggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>96
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>96
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileserileaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpasnglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>97
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>97
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcaggacattagaaatgatttaggctggtatcggcagaaacct120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>98
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>98
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnaspileargasnasp
202530
leuglytrptyrargglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>99
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>99
caggtgcagctgcaggagtcgggcccaggactggtgaagcctacacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgacttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagca300
gattacgatttttggagtggttactttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>100
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>100
glnvalglnleuglngluserglyproglyleuvallysprothrgln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargleuthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>101
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>101
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataataattacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>102
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>102
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnasntyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>103
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>103
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagtagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagttgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>104
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>104
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>105
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>105
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataataattacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>106
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>106
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnasntyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>107
<211>351
<212>dna
<213>artificial
<220>
<223>antibody
<400>107
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtggttactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagag300
gacgacggtatggacgtctggggccaagggaccacggtcaccgtctcctca351
<210>108
<211>117
<212>prt
<213>artificial
<220>
<223>antibody
<400>108
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaarggluaspaspglymetaspvaltrpglyglnglythrthr
100105110
valthrvalserser
115
<210>109
<211>336
<212>dna
<213>artificial
<220>
<223>antibody
<400>109
gatattgtgatgactcagtctccactctccctgcccgtcacccctggagagccggcctcc60
atttcctgcaggtctagtcagagcctcctgcatagtaatggatacaactatttggaatgg120
tacctgcagaagccagggcagtccccacagttcatgatttatttggggtctaatcgggcc180
tccggggtccctgacaggttcagtggcagtggatcaggcacagattttacactgaaaatc240
agcagagtggaggctgaggatgttggggtttattactgcatgcaagctctacaaactccg300
atcaccttcggccaagggacacgactggagattaaa336
<210>110
<211>112
<212>prt
<213>artificial
<220>
<223>antibody
<400>110
aspilevalmetthrglnserproleuserleuprovalthrprogly
151015
gluproalaserilesercysargserserglnserleuleuhisser
202530
asnglytyrasntyrleuglutrptyrleuglnlysproglyglnser
354045
proglnphemetiletyrleuglyserasnargalaserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglnala
859095
leuglnthrproilethrpheglyglnglythrargleugluilelys
100105110
<210>111
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>111
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagtacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgaggtctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>112
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>112
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglntyrproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuargservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>113
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>113
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatacttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>114
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>114
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnthrtyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>115
<211>372
<212>dna
<213>artificial
<220>
<223>antibody
<400>115
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctc60
acctgcactgtctctggtggctccgtcagcagtggtggttactactggagctggatccgg120
cagcccccagggaagggactggagtggattgggtatatctattacagtgggagcaccaac180
tacaacccctccctcaagagtcgagtcaccatatcagtagacacgtccaagaaccagttc240
tccctgaagctgagctctgtgaccgctgcggacacggccgtgtattactgtgcgagagat300
ggggacgtggatacagctatggtcgatgcttttgatatctggggccaagggacaatggtc360
accgtctcctca372
<210>116
<211>124
<212>prt
<213>artificial
<220>
<223>antibody
<400>116
glnvalglnleuglngluserglyproglyleuvallysproserglu
151015
thrleuserleuthrcysthrvalserglyglyservalsersergly
202530
glytyrtyrtrpsertrpileargglnproproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrasntyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargaspglyaspvalaspthralametvalaspalapheasp
100105110
iletrpglyglnglythrmetvalthrvalserser
115120
<210>117
<211>324
<212>dna
<213>artificial
<220>
<223>antibody
<400>117
gaaattgtattgacgcagtctccaggcaccctgtctttgtctccaggggaaagagccacc60
ctctcctgcagggccagtcagagtttaagcggcaactacttagcctggtaccagcagaag120
cctggccaggctcccaggctcatcatctgtggtgcatccagcagggccactggcatccca180
gacaggttcagtggcagtgggtctgggacagacttcactctcaccatcacaagactggag240
cctgaagattttgcagtgtattactgtcagcagtatgataggtcaccgctcactttcggc300
ggagggaccaaggtggagatcaaa324
<210>118
<211>108
<212>prt
<213>artificial
<220>
<223>antibody
<400>118
gluilevalleuthrglnserproglythrleuserleuserprogly
151015
gluargalathrleusercysargalaserglnserleuserglyasn
202530
tyrleualatrptyrglnglnlysproglyglnalaproargleuile
354045
ilecysglyalaserserargalathrglyileproaspargpheser
505560
glyserglyserglythraspphethrleuthrilethrargleuglu
65707580
progluaspphealavaltyrtyrcysglnglntyraspargserpro
859095
leuthrpheglyglyglythrlysvalgluilelys
100105
<210>119
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>119
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagga300
gattacgatttttggagtggagagtttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>120
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>120
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargglyasptyraspphetrpserglyglupheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>121
<211>386
<212>dna
<213>artificial
<220>
<223>antibody
<400>121
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtggttactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctatgacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgaggtctgtgactgccgcggacacggccgtgtattactgtgcgagagat300
caggggcaggacggatacagctatggttacggctactactacggtatggacgtctggggc360
caagggaccacggtcaccgtctcctc386
<210>122
<211>128
<212>prt
<213>artificial
<220>
<223>antibody
<400>122
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyraspserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuargservalthralaalaaspthralavaltyrtyr
859095
cysalaargaspglnglyglnaspglytyrsertyrglytyrglytyr
100105110
tyrtyrglymetaspvaltrpglyglnglythrthrvalthrvalser
115120125
<210>123
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>123
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccaggcgagtcaggacattagcaattatttaaattggtatcagcagaaacca120
gggaaagcccctaaactcctgatctacgttgcatccaatttggaaacaggggtcccatca180
aggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcct240
gaagatattgcaacatattactgtcaacagtgtgataatctccctctcactttcggcgga300
gggaccaaggtggagatcaaa321
<210>124
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>124
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysglnalaserglnaspileserasntyr
202530
leuasntrptyrglnglnlysproglylysalaprolysleuleuile
354045
tyrvalalaserasnleugluthrglyvalproserargphesergly
505560
serglyserglythraspphethrphethrileserserleuglnpro
65707580
gluaspilealathrtyrtyrcysglnglncysaspasnleuproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
<210>125
<211>365
<212>dna
<213>artificial
<220>
<223>antibody
<400>125
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattggatacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctc365
<210>126
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>126
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalser
115120
<210>127
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>127
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcaggacattagaaatgatttaggctggtatcggcagaaacct120
gggaaagcccctaagcgcctgatctatgctgcatcccgtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>128
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>128
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnaspileargasnasp
202530
leuglytrptyrargglnlysproglylysalaprolysargleuile
354045
tyralaalaserargleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>129
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>129
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>130
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>130
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>131
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>131
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaaatggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>132
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>132
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnasnglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>133
<211>365
<212>dna
<213>artificial
<220>
<223>antibody
<400>133
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactactggggccagggaatcctggtcaccgtc360
tcctc365
<210>134
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>134
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglyileleuvalthrvalser
115120
<210>135
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>135
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatttatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>136
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>136
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>137
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>137
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagtagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagttgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggaatggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>138
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>138
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpasnglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>139
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>139
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataataattacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>140
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>140
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnasntyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>141
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>141
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>142
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>142
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>143
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>143
gacatccagctgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaaatggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>144
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>144
aspileglnleuthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnasnglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>145
<211>365
<212>dna
<213>artificial
<220>
<223>antibody
<400>145
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagtacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgggctctgtgactgccgcggacacggccgtgtatttctgtgcgagagcc300
gattacgatttttggagtggttattttgacttctggggccagggaaccctggtcaccgtc360
tcctc365
<210>146
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>146
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglntyrproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuglyservalthralaalaaspthralavaltyrphe
859095
cysalaargalaasptyraspphetrpserglytyrpheaspphetrp
100105110
glyglnglythrleuvalthrvalser
115120
<210>147
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>147
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatggttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>148
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>148
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnglytyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>149
<211>365
<212>dna
<213>artificial
<220>
<223>antibody
<400>149
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagtacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgggctctgtgactgccgcggacacggccgtgtatttctgtgcgagagcc300
gattacgatttttggagtggttattttgacttctggggccagggaaccctggtcaccgtc360
tcctc365
<210>150
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>150
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglntyrproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuglyservalthralaalaaspthralavaltyrphe
859095
cysalaargalaasptyraspphetrpserglytyrpheaspphetrp
100105110
glyglnglythrleuvalthrvalser
115120
<210>151
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>151
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatggttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>152
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>152
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnglytyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>153
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>153
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagtagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg300
gattacgatttttggagtggttattttgactcctggggccagggaaccctggtcaccgtc360
tcctca366
<210>154
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>154
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheaspsertrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>155
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>155
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagatacct120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatggttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>156
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>156
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnileproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnglytyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>157
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>157
caggttcagctggtgcagtctggagctgaggtgaagaagcctggggcctcagtgaaggtc60
tcctgcaaggcttctggttacacctttaccaactatggtatcagctgggtgcggcaggcc120
cctggacaagggcttgagtggatgggatggatcagcgcttacgatggttacagaaactat180
gcacagaagctccagggcagagtcaccatgaccacagacacatccacgaccactgcctac240
atggagctgaggagcctgagatctgacgacacggccgtgtattactgtgcgagagatgtt300
caagactacggtgactacgactactttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>158
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>158
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysalaserglytyrthrphethrasntyr
202530
glyilesertrpvalargglnalaproglyglnglyleuglutrpmet
354045
glytrpileseralatyraspglytyrargasntyralaglnlysleu
505560
glnglyargvalthrmetthrthraspthrserthrthrthralatyr
65707580
metgluleuargserleuargseraspaspthralavaltyrtyrcys
859095
alaargaspvalglnasptyrglyasptyrasptyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>159
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>159
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagagcattagcagttatttaaattggtatcagcagaaacca120
gggaaagcccctaacctcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
agattcaggggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct240
gaagattttgcaacttactactgtcaacagagttacagtacccccatcaccttcggccaa300
gggacacgactggagattaaa321
<210>160
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>160
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserilesersertyr
202530
leuasntrptyrglnglnlysproglylysalaproasnleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphearggly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserthrproile
859095
thrpheglyglnglythrargleugluilelys
100105
<210>161
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>161
caggtgcagctgcaggagtcgggcccaggactggtgaagcctttacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggaccacctac180
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
gccctgaagctgaactctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggagtggttattttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>162
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>162
glnvalglnleuglngluserglyproglyleuvallysproleugln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglythrthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
alaleulysleuasnservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>163
<211>322
<212>dna
<213>artificial
<220>
<223>antibody
<400>163
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaggtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctcagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattctctctcacaatctccagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaac322
<210>164
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>164
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaglyglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaproglnargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrglupheserleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>165
<211>369
<212>dna
<213>artificial
<220>
<223>antibody
<400>165
caggtgcagctggtggagtctgggggaggcttggtcaagcctggagggtccctgagactc60
tcctgtgcagcctctggattcaccttcagtgactactacatgagctggatccgccaggct120
ccagggaaggggctggagtgggtttcatatattagtagtagtggtaataacatataccac180
gcagactctgtgaagggccgattcaccatctccagggacaacgccaagaactcactgtat240
ctgcaaatgaacagcctgagagccgaggacacggccgtgtattactgtgcgagagagaga300
tatagtggctacgacgaccctgatggttttgatatctggggccaagggacaatggtcacc360
gtctcttca369
<210>166
<211>123
<212>prt
<213>artificial
<220>
<223>antibody
<400>166
glnvalglnleuvalgluserglyglyglyleuvallysproglygly
151015
serleuargleusercysalaalaserglyphethrpheserasptyr
202530
tyrmetsertrpileargglnalaproglylysglyleuglutrpval
354045
sertyrileserserserglyasnasniletyrhisalaaspserval
505560
lysglyargphethrileserargaspasnalalysasnserleutyr
65707580
leuglnmetasnserleuargalagluaspthralavaltyrtyrcys
859095
alaarggluargtyrserglytyraspaspproaspglypheaspile
100105110
trpglyglnglythrmetvalthrvalserser
115120
<210>167
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>167
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccaggcgagtcaggacattagcaactatttaagttggtttcagcagaaacca120
gggaaagcccctaagctcctgatccacgatgcatccaatttggaaacaggggtcccttca180
aggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcct240
gaagatattgcaacatattactgtcaacagtatgataatcccccgtgcagttttggccag300
gggaccaagctggagatcaaa321
<210>168
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>168
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysglnalaserglnaspileserasntyr
202530
leusertrppheglnglnlysproglylysalaprolysleuleuile
354045
hisaspalaserasnleugluthrglyvalproserargphesergly
505560
serglyserglythraspphethrphethrileserserleuglnpro
65707580
gluaspilealathrtyrtyrcysglnglntyraspasnproprocys
859095
serpheglyglnglythrlysleugluilelys
100105
<210>169
<211>366
<212>dna
<213>artificial
<220>
<223>antibody
<400>169
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc60
acctgcactgtctctggtggctccatcagcagtggttattactactggagctggatccgc120
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggaccacctac180
tacaatccgtccttcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc240
tccctgaaactgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcc300
gattacgatttttggagtggtcactttgactactggggccagggaaccctggtcaccgtc360
tcctca366
<210>170
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>170
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
tyrtyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglythrthrtyrtyrasnproser
505560
phelysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglyhispheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>171
<211>321
<212>dna
<213>artificial
<220>
<223>antibody
<400>171
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc60
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca120
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca180
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct240
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa300
gggaccaaggtggaaatcaaa321
<210>172
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>172
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>173
<211>365
<212>dna
<213>artificial
<220>
<223>antibody
<400>173
caggttcagctggtgcagtctggagctgaggtgaagaagcctggggcctcagtgaaggtc60
tcctgcaaggcttctggttacacctttaccagctatggtatcagctgggtgcgacaggcc120
cctggacaaggacttgagtggatgggatggatcagcgcttacgatggtcacacaaactat180
gcacagaagctccagggcagagtcaccatgaccacagacacatccacgaacacagcctac240
atggagctgaggagcctgagatctgacgacacggccgtttattactgtgcgagagacccc300
catgactacagtaactacgaggcttttgacttctggggccagggaaccctggtcaccgtc360
tcctc365
<210>174
<211>121
<212>prt
<213>artificial
<220>
<223>antibody
<400>174
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysalaserglytyrthrphethrsertyr
202530
glyilesertrpvalargglnalaproglyglnglyleuglutrpmet
354045
glytrpileseralatyraspglyhisthrasntyralaglnlysleu
505560
glnglyargvalthrmetthrthraspthrserthrasnthralatyr
65707580
metgluleuargserleuargseraspaspthralavaltyrtyrcys
859095
alaargaspprohisasptyrserasntyrglualapheaspphetrp
100105110
glyglnglythrleuvalthrvalser
115120
<210>175
<211>519
<212>dna
<213>artificial
<220>
<223>antibody
<400>175
atgaggtcccctgctcagctcctggggctcctgctactctggctccgaggtgccagatgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagagcattagcagttatttaaattggtatcagcagaaacca180
gggaaagcccctaacctcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
agattcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacct300
gaagattttgcaacttactactgtcaacagagttacagtacccccatcaccttcggccaa360
gggacacgactggagattaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgcc519
<210>176
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>176
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserilesersertyr
202530
leuasntrptyrglnglnlysproglylysalaproasnleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserthrproile
859095
thrpheglyglnglythrargleugluilelys
100105
<210>177
<211>534
<212>dna
<213>artificial
<220>
<223>antibody
<400>177
accatggactggacctggagggtccttttcttggtggcagcagcaacaggtgcccactcc60
caggttcagctggtgcagtctggagctgaggtgaagaagcctggggcctcagtgaaggtc120
tcctgcaaggcttctggttacacctttaccaactatggtatcagctgggtgcggcaggcc180
cctggacaagggcttgagtggatgggatggatcagcgcttacgatggttacagaaactat240
gcacagaagctccagggcagagtcaccatgaccacagacacatccacgaccactgcctac300
atggagctgaggagcctgagatctgacgacacggccgtgtattactgtgcgagagatgtt360
caagactacggtgactacgactactttgactactggggccagggaaccctggtcaccgtc420
tcctcagcttccaccaagggcccatccgtcttccccctggtgccctgctccaggagcacc480
tccgagagcacagccgccctgggctgcctggtcaaggactacttccccgaaccg534
<210>178
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>178
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysalaserglytyrthrphethrasntyr
202530
glyilesertrpvalargglnalaproglyglnglyleuglutrpmet
354045
glytrpileseralatyraspglytyrargasntyralaglnlysleu
505560
glnglyargvalthrmetthrthraspthrserthrthrthralatyr
65707580
metgluleuargserleuargseraspaspthralavaltyrtyrcys
859095
alaargaspvalglnasptyrglyasptyrasptyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>179
<211>504
<212>dna
<213>artificial
<220>
<223>antibody
<400>179
cagctcctggggctcctgctactctggctccgaggtgccagatgtgacatccagatgacc60
cagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggca120
agtcagagcattagcagttatttaaattggtatcagcagaaaccagggaaagcccctaac180
ctcctgatctatgctgcatccagtttgcaaagtggggtcccatcaagattcagtggcagt240
ggatctgggacagatttcactctcaccatcagcagtctgcaacctgaagattttgcaact300
tactactgtcaacagagttacagtacccccatcaccttcggccaagggacacgactggag360
attaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttg420
aaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaa480
gtacagtggaaggtggataacgcc504
<210>180
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>180
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnserilesersertyr
202530
leuasntrptyrglnglnlysproglylysalaproasnleuleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythraspphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysglnglnsertyrserthrproile
859095
thrpheglyglnglythrargleugluilelys
100105
<210>181
<211>493
<212>dna
<213>artificial
<220>
<223>antibody
<400>181
catctgtggttcttcctcctgctggtggcagctcccagatgggtcctgtcccaggtgcag60
ctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcact120
gtctctggtggctccatcaacagtggtgattactactggagctggatccgccagcaccca180
gggaagggcctggagtggattgggtacatctattacagtgggagcacctactacaacccg240
tccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaag300
ctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcagattacgat360
ttttggagtggttactttgactactggggccagggaaccctggtcaccgtctcctcagcc420
tccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggc480
acaacggccctgg493
<210>182
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>182
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserileasnsergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>183
<211>518
<212>dna
<213>artificial
<220>
<223>antibody
<400>183
atgagggtccctgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgc518
<210>184
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>184
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>185
<211>436
<212>dna
<213>artificial
<220>
<223>antibody
<400>185
tggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtggttactactggagctggatccgccagcacccagggaag180
ggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtattactgtgcgagagatggctatgatagtagt360
ggttattaccacggctactttgactactggggccagggaaccctggtcaccgtctcctca420
gcctccaccaagggcc436
<210>186
<211>125
<212>prt
<213>artificial
<220>
<223>antibody
<400>186
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
glytyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargaspglytyraspserserglytyrtyrhisglytyrphe
100105110
asptyrtrpglyglnglythrleuvalthrvalserser
115120125
<210>187
<211>521
<212>dna
<213>artificial
<220>
<223>antibody
<400>187
caggtcttcatttctctgttgctctggatctctggtgcctacggggacatcgtgatgacc60
cagtctccagactccctggctgtgtctctgggcgagagggccaccatcaactgcaagtcc120
agccagagtgttttatacagctccaacaataagaactacttagcttggtaccagcagaaa180
ccaggacagcctcctaagctgctcatttactgggcatctacccgggaatccggggtccct240
gaccgattcagtggcagcgggtctgggacagatttcactctcaccatcagcagcctgcag300
gctgaagatgtggcagtttattactgtcagcaatattatagtactccgctcactttcggc360
ggagggaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccg420
ccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttc480
tatcccagagaggccaaagtacagtggaaggtggataacgc521
<210>188
<211>113
<212>prt
<213>artificial
<220>
<223>antibody
<400>188
aspilevalmetthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serasnasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrproleuthrpheglyglyglythrlysvalgluile
100105110
lys
<210>189
<211>455
<212>dna
<213>artificial
<220>
<223>antibody
<400>189
ctgtggttcttcctcctgctggtggcagctcccagatgggtcctgtcccaggtgcagctg60
caggagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtc120
tctggtggctccatcagtagtggtgattactactggagctggatccgccagcacccaggg180
aagggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtcc240
ctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagttg300
agctctgtgactgccgcggacacggccgtgtattactgtgcgagagccgattacgatttt360
tggagtggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctcc420
accaagggcccatcggtcttccccctggcaccctc455
<210>190
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>190
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>191
<211>442
<212>dna
<213>artificial
<220>
<223>antibody
<400>191
gtgcccgctcagcgcctggggctcctgctgctctggttcccaggtgccaggtgtgacatc60
cagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcact120
tgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaaccagggaaa180
gcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatcaaggttc240
agcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcctgaagat300
tttgcaacttattactgtctacagcataataattacccgtggacgttcggccaagggacc360
aaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgat420
gagcagttgaaatctggaactg442
<210>192
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>192
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnasntyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>193
<211>427
<212>dna
<213>artificial
<220>
<223>antibody
<400>193
tggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtgattactactggagctggatccgccagcacccagggaag180
ggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtatttctgtgcgagagccgattacgatttttgg360
agtggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctccacc420
aagggcc427
<210>194
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>194
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrphe
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>195
<211>518
<212>dna
<213>artificial
<220>
<223>antibody
<400>195
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatacttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgc518
<210>196
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>196
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnthrtyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>197
<211>428
<212>dna
<213>artificial
<220>
<223>antibody
<400>197
tggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtgattactactggagctggatccgccagcacccagggaag180
ggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtatttctgtgcgagagccgattacgatttttgg360
aatggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctccacc420
aagggccc428
<210>198
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>198
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrphe
859095
cysalaargalaasptyraspphetrpasnglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>199
<211>519
<212>dna
<213>artificial
<220>
<223>antibody
<400>199
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcttccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatacttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgcc519
<210>200
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>200
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnthrtyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>201
<211>398
<212>dna
<213>artificial
<220>
<223>antibody
<400>201
ttggtggcagcagctacaggcacccacgcccaggtccagctggtacagtctggggctgag60
gtgaagaagcctggggcctcagtgaaggtctcctgcaaggtttccggatacaccctcact120
gaattatccatgtactgggtgcgacaggctcctggaaaagggcttgagtggatgggaggt180
tttgatcctgaagatggtgaaacaatctacgcacagaagttccagggcagagtcaccatg240
accgaggacacatctacagacacagcctacatggagctgagcagcctgagatctgaggac300
acggccgtgtattactgtgcaactgggtggaactacgtctttgactactggggccaggga360
accctggtcaccgtctcctcagcctccaccaagggccc398
<210>202
<211>117
<212>prt
<213>artificial
<220>
<223>antibody
<400>202
glnvalglnleuvalglnserglyalagluvallyslysproglyala
151015
servallysvalsercyslysvalserglytyrthrleuthrgluleu
202530
sermettyrtrpvalargglnalaproglylysglyleuglutrpmet
354045
glyglypheaspprogluaspglygluthriletyralaglnlysphe
505560
glnglyargvalthrmetthrgluaspthrserthraspthralatyr
65707580
metgluleuserserleuargsergluaspthralavaltyrtyrcys
859095
alathrglytrpasntyrvalpheasptyrtrpglyglnglythrleu
100105110
valthrvalserser
115
<210>203
<211>388
<212>dna
<213>artificial
<220>
<223>antibody
<400>203
ggatccagtggggatattgtgatgactcagtctccactctccctgcccgtcacccctgga60
gagccggcctccatctcctgcaggtccagtcagagcctcctgcatagtaatggatacaac120
tatttggattggtacctgcagaagccagggcagtctccacagctcctgatctatttggat180
tctcatcgggcctccggggtccctgacaggttcagtggcagtggatcaggcacagatttt240
acactgaaaatcagcagagtggaggctgaggatgttggggtttattactgcatgcaagct300
ctacaaactccgctcactttcggcggagggaccaaggtggagatcaaacgaactgtggct360
gcaccatctgtcttcatcttcccgccat388
<210>204
<211>112
<212>prt
<213>artificial
<220>
<223>antibody
<400>204
aspilevalmetthrglnserproleuserleuprovalthrprogly
151015
gluproalaserilesercysargserserglnserleuleuhisser
202530
asnglytyrasntyrleuasptrptyrleuglnlysproglyglnser
354045
proglnleuleuiletyrleuaspserhisargalaserglyvalpro
505560
aspargpheserglyserglyserglythraspphethrleulysile
65707580
serargvalglualagluaspvalglyvaltyrtyrcysmetglnala
859095
leuglnthrproleuthrpheglyglyglythrlysvalgluilelys
100105110
<210>205
<211>446
<212>dna
<213>artificial
<220>
<223>antibody
<400>205
tggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtgattactactggagctggatccgccagcacccagggaag180
ggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtatttctgtgcgagagccgattacgatttttgg360
agtggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctccacc420
aagggcccatcgagtcttccccctgg446
<210>206
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>206
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrphe
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>207
<211>519
<212>dna
<213>artificial
<220>
<223>antibody
<400>207
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacaaaattcactctcactatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatacttacccgtggacgttcggccaa360
gggaccaaggtggaaatcagacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgcc519
<210>208
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>208
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrlysphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnthrtyrprotrp
859095
thrpheglyglnglythrlysvalgluilearg
100105
<210>209
<211>564
<212>dna
<213>artificial
<220>
<223>antibody
<400>209
accatgaaacatctgtggttcttcctcctgctggtggcagctcccagatgggtcctgtcc60
caggtgcagctgcaggagtcgggcccaggactggtgaagccttcacagaccctgtccctc120
acctgcactgtctctggtggctccatcagcagtggtgattactactggagctggatccgc180
cagcacccagggaagggcctggagtggattgggtacatctattacagtgggagcacctac240
tacaacccgtccctcaagagtcgagttaccatatcagtagacacgtctaagaaccagttc300
tccctgaagctgagctctgtgactgccgcggacacggccgtgtattactgtgcgagagcg360
gattacgatttttggagtggttattttgactactggggccagggaatcctggtcaccgtc420
tcctcagcctccaccaagggcccatcggtcttccccctggcaccctcctccaagaacacc480
tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacg540
gtgtcctggaactcaggcgccctg564
<210>210
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>210
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglyileleuvalthrvalserser
115120
<210>211
<211>519
<212>dna
<213>artificial
<220>
<223>antibody
<400>211
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgcc519
<210>212
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>212
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>213
<211>432
<212>dna
<213>artificial
<220>
<223>antibody
<400>213
tggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtgattactactggagctggatccgccagcacccagggaag180
ggcctggagtggattggatacatctattacagtgggagcacctactacaattcgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtattactgtgcgagagcggattacgatttttgg360
agtggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctccacc420
aagggcccatcg432
<210>214
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>214
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnserser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>215
<211>372
<212>dna
<213>artificial
<220>
<223>antibody
<400>215
ggtgccaggtgtgacatccagatgacccagtctccatcctccctgtctgcatctgtagga60
gacagagtcaccatcacttgccgggcaagtcagggcattagaaatgatttaggctggtat120
cagcagaaacctgggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagt180
ggggtcccatcaaggttcagcggcagtggatctgggacagaattcactctcacaatcagc240
agcctgcagcctgaagattttgcaacttattactgtctacagcacaatagttacccgtgg300
acgttcggccaagggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttc360
atcttcccgcca372
<210>216
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>216
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>217
<211>548
<212>dna
<213>artificial
<220>
<223>antibody
<400>217
aggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctgcag60
gagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtctct120
ggtggctccatcagcagtggtgattactactggagctggatccgccagcacccagggaag180
ggcctggagtggattggatacatctattacagtgggagcacctactacaacccgtccctc240
aagagtcgagttaccatatcagtagacacgtctaagaaccagttctccctgaagctgagc300
tctgtgactgccgcggacacggccgtgtattactgtgcgagagccgattacgatttttgg360
agtggttattttgactactggggccagggaaccctggtcaccgtctcctcagcctccacc420
aagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcg480
gccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactca540
ggcgccct548
<210>218
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>218
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>219
<211>517
<212>dna
<213>artificial
<220>
<223>antibody
<400>219
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacg517
<210>220
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>220
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>221
<211>446
<212>dna
<213>artificial
<220>
<223>antibody
<400>221
ctgtggttcttccttctgctggtggcagctcccagatgggtcctgtcccaggtgcagctg60
caggagtcgggcccaggactggtgaagccttcacagaccctgtccctcacctgcactgtc120
tctggtggctccatcagcagtggtgattactactggagctggatccgccagcacccaggg180
aagggcctggagtggattgggtacatctattacagtgggagcacctactacaacccgtcc240
ctcaagagtcgagttaccatgtcagtagacacgtctaagaaccagttctccctgaagctg300
agctctgtgactgccgcggacacggccgtgtattactgtgcgagagccgattacgatttt360
tggagtggtcactttgactgctggggccagggaaccctggtcaccgtctcctcagcttcc420
accaagggccccatccgtcttccccc446
<210>222
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>222
glnvalglnleuglngluserglyproglyleuvallysprosergln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglyserthrtyrtyrasnproser
505560
leulysserargvalthrmetservalaspthrserlysasnglnphe
65707580
serleulysleuserservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglyhispheaspcystrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>223
<211>419
<212>dna
<213>artificial
<220>
<223>antibody
<400>223
atgagggtccccgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaagtcagggcattagagatgatttaggctggtatcagcagaaacca180
gggaaagcccctaagcgcctgatctatgctgaatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattcactctcacaatcagcagcctgcagcct300
gaagattttgcaacttattactgtctacagcatcatagttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcc419
<210>224
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>224
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaserglnglyileargaspasp
202530
leuglytrptyrglnglnlysproglylysalaprolysargleuile
354045
tyralagluserserleuglnserglyvalproserargphesergly
505560
serglyserglythrgluphethrleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhishissertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>225
<211>504
<212>dna
<213>artificial
<220>
<223>antibody
<400>225
tggctgagctgggttttcctcgttgctcttttaagaggtgtccagtgtcaggtgcagctg60
gtggagtctgggggaggcgtggtccagcctgggaggtccctgagactctcctgtgcagcg120
tctggattcaccttcaatagctatgacatgcactgggtccgccaggctccaggcaagggg180
ctggagtgggtggcagttatatggtatgatggaagtaataaatactatgcagactccgtg240
aagggccgattcaccatctctagagacaattccaagaacacgctgtatctgcaaatgaac300
agcctgagagccgaggacacggctgtgtattactgtgcgagagaccgcttgtgtactaat360
ggtgtatgctatgaagactacggtatggacgtctggggccaagggaccacggtcaccgtc420
tcctcagcttccaccaagggcccatccgtcttccccctggcgccctgctccaggagcacc480
tccgagagcacagccgccctgggc504
<210>226
<211>126
<212>prt
<213>artificial
<220>
<223>antibody
<400>226
glnvalglnleuvalgluserglyglyglyvalvalglnproglyarg
151015
serleuargleusercysalaalaserglyphethrpheasnsertyr
202530
aspmethistrpvalargglnalaproglylysglyleuglutrpval
354045
alavaliletrptyraspglyserasnlystyrtyralaaspserval
505560
lysglyargphethrileserargaspasnserlysasnthrleutyr
65707580
leuglnmetasnserleuargalagluaspthralavaltyrtyrcys
859095
alaargaspargleucysthrasnglyvalcystyrgluasptyrgly
100105110
metaspvaltrpglyglnglythrthrvalthrvalserser
115120125
<210>227
<211>504
<212>dna
<213>artificial
<220>
<223>antibody
<400>227
atgagggtccctgctcagctcctggggctcctgctgctctggctctcaggtgccagatgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccaggcgagtcaggacattagcaactatttaaattggtatcagcagaaacca180
gggaaagcccctaaggtcctgatctacgatgcatccaatttggaaacaggggtcccatca240
aggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcct300
gaagatgttgcaacatattactgtcaacactatgatactctcccgctcactttcggcgga360
gggaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtgg504
<210>228
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>228
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysglnalaserglnaspileserasntyr
202530
leuasntrptyrglnglnlysproglylysalaprolysvalleuile
354045
tyraspalaserasnleugluthrglyvalproserargphesergly
505560
serglyserglythraspphethrphethrileserserleuglnpro
65707580
gluaspvalalathrtyrtyrcysglnhistyraspthrleuproleu
859095
thrpheglyglyglythrlysvalgluilelys
100105
<210>229
<211>472
<212>dna
<213>artificial
<220>
<223>antibody
<400>229
ggactgtgcaagaacatgaaacacctgtggttcttcctcctgctggtggcagctcccaga60
tgggtcctgtcccaggtgcagctgcaggagtcgggcccaggactggtgaagcctttacag120
accctgtccctcacctgcactgtctctggtggctccatcagcagtggtgattactactgg180
agctggatccgccagcacccagggaagggcctggagtggattgggtacatctattacagt240
gggaccacctactacaacccgtccctcaagagtcgagttaccatatcagtagacacgtct300
aagaaccagttcgccctgaagctgaactctgtgactgccgcggacacggccgtgtattac360
tgtgcgagagccgattacgatttttggagtggttattttgactactggggccagggaacc420
ctggtcaccgtctcctcagcttccaccaagggcccatccgtcttccccctgg472
<210>230
<211>122
<212>prt
<213>artificial
<220>
<223>antibody
<400>230
glnvalglnleuglngluserglyproglyleuvallysproleugln
151015
thrleuserleuthrcysthrvalserglyglyserilesersergly
202530
asptyrtyrtrpsertrpileargglnhisproglylysglyleuglu
354045
trpileglytyriletyrtyrserglythrthrtyrtyrasnproser
505560
leulysserargvalthrileservalaspthrserlysasnglnphe
65707580
alaleulysleuasnservalthralaalaaspthralavaltyrtyr
859095
cysalaargalaasptyraspphetrpserglytyrpheasptyrtrp
100105110
glyglnglythrleuvalthrvalserser
115120
<210>231
<211>531
<212>dna
<213>artificial
<220>
<223>antibody
<400>231
atgagggtccctgctcagctcctggggctcctgctgctctggttcccaggtgccaggtgt60
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcacc120
atcacttgccgggcaggtcagggcattagaaatgatttaggctggtatcagcagaaacca180
gggaaagcccctcagcgcctgatctatgctgcatccagtttgcaaagtggggtcccatca240
aggttcagcggcagtggatctgggacagaattctctctcacaatctccagcctgcagcct300
gaagattttgcaacttattactgtctacagcataatagttacccgtggacgttcggccaa360
gggaccaaggtggaaatcaaacgaactgtggctgcaccatctgtcttcatcttcccgcca420
tctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctat480
cccagagaggccaaagtacagtggaaggtggataacgcccttccaatcggg531
<210>232
<211>107
<212>prt
<213>artificial
<220>
<223>antibody
<400>232
aspileglnmetthrglnserproserserleuseralaservalgly
151015
aspargvalthrilethrcysargalaglyglnglyileargasnasp
202530
leuglytrptyrglnglnlysproglylysalaproglnargleuile
354045
tyralaalaserserleuglnserglyvalproserargphesergly
505560
serglyserglythrglupheserleuthrileserserleuglnpro
65707580
gluaspphealathrtyrtyrcysleuglnhisasnsertyrprotrp
859095
thrpheglyglnglythrlysvalgluilelys
100105
<210>233
<211>26
<212>dna
<213>artificial
<220>
<223>primer
<220>
<221>prim_transcript
<222>(1)..(26)
<400>233
cgggatccatgtcctagcctaggggc26
<210>234
<211>39
<212>dna
<213>artificial
<220>
<223>primer
<220>
<221>prim_transcript
<222>(1)..(39)
<400>234
gctctagattaatgatgatgatgatgatgttgtcctaaa39
<210>235
<211>12
<212>prt
<213>artificial
<220>
<223>u1-1cdr-1-h
<400>235
glyglyserileasnserglyasptyrtyrtrpser
1510
<210>236
<211>16
<212>prt
<213>artificial
<220>
<223>u1-1cdr-2-h
<400>236
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>237
<211>12
<212>prt
<213>artificial
<220>
<223>u1-1cdr-3-h
<400>237
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>238
<211>11
<212>prt
<213>artificial
<220>
<223>u1-1cdr-1-l
<400>238
argalaserglnglyileargasnaspleugly
1510
<210>239
<211>7
<212>prt
<213>artificial
<220>
<223>u1-1cdr-2-l
<400>239
alaalaserserleuglnser
15
<210>240
<211>9
<212>prt
<213>artificial
<220>
<223>u1-1cdr-3-l
<400>240
leuglnhisasnsertyrprotrpthr
15
<210>241
<211>12
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-1h
<400>241
glyglyserileserserglyasptyrtyrtrpser
1510
<210>242
<211>16
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-2h
<400>242
tyriletyrtyrserglyserthrtyrtyrasnproserleuargser
151015
<210>243
<211>12
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-3h
<400>243
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>244
<211>11
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-1l
<400>244
argalaserglnglyileargasnaspleugly
1510
<210>245
<211>7
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-2l
<400>245
alaalaserserleuglnser
15
<210>246
<211>9
<212>prt
<213>artificial
<220>
<223>u1-2-cdr-3l
<400>246
leuglnhisasnglytyrprotrpthr
15
<210>247
<211>12
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-1-h
<400>247
glyglyserileserserglyglytyrtyrtrpser
1510
<210>248
<211>16
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-2h
<400>248
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>249
<211>15
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-3h
<400>249
aspglytyraspserserglytyrtyrhisglytyrpheasptyr
151015
<210>250
<211>17
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-1l
<400>250
lysserserglnservalleutyrserserasnasnlysasntyrleu
151015
ala
<210>251
<211>7
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-2l
<400>251
trpalaserthrarggluser
15
<210>252
<211>9
<212>prt
<213>artificial
<220>
<223>u1-3-cdr-3l
<400>252
glnglntyrtyrserthrproleuthr
15
<210>253
<211>12
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-1h
<400>253
glyglyserileserserglyasptyrtyrtrpser
1510
<210>254
<211>16
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-2h
<400>254
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>255
<211>12
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-3h
<400>255
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>256
<211>11
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-1l
<400>256
argalaserglnglyileargasnaspleugly
1510
<210>257
<211>7
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-2l
<400>257
alaalaserserleuglnser
15
<210>258
<211>9
<212>prt
<213>artificial
<220>
<223>u1-4-cdr-3l
<400>258
leuglnhisasnasntyrprotrpthr
15
<210>259
<211>12
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-1h
<400>259
glyglyserileserserglyasptyrtyrtrpser
1510
<210>260
<211>16
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-2h
<400>260
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>261
<211>12
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-3h
<400>261
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>262
<211>11
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-1l
<400>262
argalaserglnglyileargasnaspleugly
1510
<210>263
<211>7
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-2l
<400>263
alaalaserserleuglnser
15
<210>264
<211>9
<212>prt
<213>artificial
<220>
<223>u1-5-cdr-3l
<400>264
leuglnhisasnthrtyrprotrpthr
15
<210>265
<211>12
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-1h
<400>265
glyglyserileserserglyasptyrtyrtrpser
1510
<210>266
<211>16
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-2h
<400>266
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>267
<211>12
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-3h
<400>267
alaasptyraspphetrpasnglytyrpheasptyr
1510
<210>268
<211>11
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-1l
<400>268
argalaserglnglyileargasnaspleugly
1510
<210>269
<211>7
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-2l
<400>269
alaalaserserleuglnser
15
<210>270
<211>9
<212>prt
<213>artificial
<220>
<223>u1-6-cdr-3l
<400>270
leuglnhisasnthrtyrprotrpthr
15
<210>271
<211>12
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-1h
<400>271
glyglyserileserserglyasptyrtyrtrpser
1510
<210>272
<211>16
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-2h
<400>272
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>273
<211>12
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-3h
<400>273
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>274
<211>11
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-1l
<400>274
argalaserglnaspileargasnaspleugly
1510
<210>275
<211>7
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-2l
<400>275
alaalaserserleuglnser
15
<210>276
<211>9
<212>prt
<213>artificial
<220>
<223>u1-7-cdr-3l
<400>276
leuglnhisasnsertyrprotrpthr
15
<210>277
<211>10
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-1h
<400>277
glytyrthrleuthrgluleusermettyr
1510
<210>278
<211>17
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-2h
<400>278
glypheaspprogluaspglygluthriletyralaglnlysphegln
151015
gly
<210>279
<211>8
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-3h
<400>279
glytrpasntyrvalpheasptyr
15
<210>280
<211>16
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-1l
<400>280
argserserglnserleuleuhisserasnglytyrasntyrleuasp
151015
<210>281
<211>7
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-2l
<400>281
leuaspserhisargalaser
15
<210>282
<211>9
<212>prt
<213>artificial
<220>
<223>u1-8-cdr-3l
<400>282
metglnalaleuglnthrproleuthr
15
<210>283
<211>12
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-1h
<400>283
glyglyserileserserglyasptyrtyrtrpser
1510
<210>284
<211>16
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-2h
<400>284
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>285
<211>12
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-3h
<400>285
alaasptyraspphetrpasnglytyrpheasptyr
1510
<210>286
<211>11
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-1l
<400>286
argalaserglnaspileargasnaspleugly
1510
<210>287
<211>7
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-2l
<400>287
alaalaserserleuglnser
15
<210>288
<211>9
<212>prt
<213>artificial
<220>
<223>u1-9-cdr-3l
<400>288
leuglnhisasnsertyrprotrpthr
15
<210>289
<211>12
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-1h
<400>289
glyglyserileserserglyasptyrtyrtrpser
1510
<210>290
<211>16
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-2h
<400>290
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>291
<211>12
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-3h
<400>291
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>292
<211>11
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-1l
<400>292
argalaserglnglyileargasnaspleugly
1510
<210>293
<211>7
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-2l
<400>293
alaalaserserleuglnser
15
<210>294
<211>9
<212>prt
<213>artificial
<220>
<223>u1-10-cdr-3l
<400>294
leuglnhisasnasntyrprotrpthr
15
<210>295
<211>12
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-1h
<400>295
glyglyserileserserglyasptyrtyrtrpser
1510
<210>296
<211>16
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-2h
<400>296
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>297
<211>12
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-3h
<400>297
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>298
<211>11
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-1l
<400>298
argalaserglnglyileargasnaspleugly
1510
<210>299
<211>7
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-2l
<400>299
alaalaserserleuglnser
15
<210>300
<211>9
<212>prt
<213>artificial
<220>
<223>u1-11-cdr-3l
<400>300
leuglnhisasnthrtyrprotrpthr
15
<210>301
<211>12
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-1h
<400>301
glyglyserileserserglyasptyrtyrtrpser
1510
<210>302
<211>16
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-2h
<400>302
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>303
<211>12
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-3h
<400>303
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>304
<211>11
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-1l
<400>304
argalaserglnglyileargasnaspleugly
1510
<210>305
<211>7
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-2l
<400>305
alaalaserserleuglnser
15
<210>306
<211>9
<212>prt
<213>artificial
<220>
<223>u1-12-cdr-3l
<400>306
leuglnhisasnasntyrprotrpthr
15
<210>307
<211>12
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-1h
<400>307
glyglyserileserserglyglytyrtyrtrpser
1510
<210>308
<211>16
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-2h
<400>308
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>309
<211>7
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-3h
<400>309
gluaspaspglymetaspval
15
<210>310
<211>16
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-1l
<400>310
argserserglnserleuleuhisserasnglytyrasntyrleuglu
151015
<210>311
<211>7
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-2l
<400>311
leuglyserasnargalaser
15
<210>312
<211>9
<212>prt
<213>artificial
<220>
<223>u1-13-cdr-3l
<400>312
metglnalaleuglnthrproilethr
15
<210>313
<211>12
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-1h
<400>313
glyglyserileserserglyasptyrtyrtrpser
1510
<210>314
<211>16
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-2h
<400>314
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>315
<211>12
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-3h
<400>315
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>316
<211>11
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-1l
<400>316
argalaserglnglyileargasnaspleugly
1510
<210>317
<211>7
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-2l
<400>317
alaalaserserleuglnser
15
<210>318
<211>9
<212>prt
<213>artificial
<220>
<223>u1-14-cdr-3l
<400>318
leuglnhisasnthrtyrprotrpthr
15
<210>319
<211>12
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-1h
<400>319
glyglyservalserserglyglytyrtyrtrpser
1510
<210>320
<211>16
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-2h
<400>320
tyriletyrtyrserglyserthrasntyrasnproserleulysser
151015
<210>321
<211>14
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-3h
<400>321
aspglyaspvalaspthralametvalaspalapheaspile
1510
<210>322
<211>12
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-1l
<400>322
argalaserglnserleuserglyasntyrleuala
1510
<210>323
<211>7
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-2l
<400>323
glyalaserserargalathr
15
<210>324
<211>9
<212>prt
<213>artificial
<220>
<223>u1-15-cdr-3l
<400>324
glnglntyraspargserproleuthr
15
<210>325
<211>12
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-1h
<400>325
glyglyserileserserglyasptyrtyrtrpser
1510
<210>326
<211>16
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-2h
<400>326
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>327
<211>12
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-3h
<400>327
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>328
<211>11
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-1l
<400>328
argalaserglnglyileargasnaspleugly
1510
<210>329
<211>7
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-2l
<400>329
alaalaserserleuglnser
15
<210>330
<211>9
<212>prt
<213>artificial
<220>
<223>u1-16-cdr-3l
<400>330
leuglnhisasnsertyrprotrpthr
15
<210>331
<211>12
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-1h
<400>331
glyglyserileserserglyasptyrtyrtrpser
1510
<210>332
<211>16
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-2h
<400>332
tyriletyrtyrserglyserthrtyrtyrasnserserleulysser
151015
<210>333
<211>12
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-3h
<400>333
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>334
<211>11
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-1l
<400>334
argalaserglnglyileargasnaspleugly
1510
<210>335
<211>7
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-2l
<400>335
alaalaserserleuglnser
15
<210>336
<211>9
<212>prt
<213>artificial
<220>
<223>u1-17-cdr-3l
<400>336
leuglnhisasnsertyrprotrpthr
15
<210>337
<211>12
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-1h
<400>337
glyglyserileserserglyasptyrtyrtrpser
1510
<210>338
<211>16
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-2h
<400>338
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>339
<211>12
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-3h
<400>339
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>340
<211>11
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-1l
<400>340
argalaserglnglyileargasnaspleugly
1510
<210>341
<211>7
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-2l
<400>341
alaalaserserleuglnser
15
<210>342
<211>9
<212>prt
<213>artificial
<220>
<223>u1-18-cdr-3l
<400>342
leuglnhisasnsertyrprotrpthr
15
<210>343
<211>12
<212>prt
<213>artificial
<220>
<223>u1-19-cdr-1h
<400>343
glyglyserileserserglyasptyrtyrtrpser
1510
<210>344
<211>16
<212>prt
<213>artificial
<220>
<223>u1-19-cdr-2h
<400>344
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>345
<211>12
<212>prt
<213>artificial
<220>
<223>u1-19-cdr-3h
<400>345
glyasptyraspphetrpserglyglupheasptyr
1510
<210>346
<211>12
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-1h
<400>346
glyglyserileserserglyglytyrtyrtrpser
1510
<210>347
<211>16
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-2h
<400>347
tyriletyraspserglyserthrtyrtyrasnproserleulysser
151015
<210>348
<211>19
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-3h
<400>348
aspglnglyglnaspglytyrsertyrglytyrglytyrtyrtyrgly
151015
metaspval
<210>349
<211>11
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-1l
<400>349
glnalaserglnaspileserasntyrleuasn
1510
<210>350
<211>7
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-2l
<400>350
valalaserasnleugluthr
15
<210>351
<211>9
<212>prt
<213>artificial
<220>
<223>u1-20-cdr-3l
<400>351
glnglncysaspasnleuproleuthr
15
<210>352
<211>12
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-1h
<400>352
glyglyserileserserglyasptyrtyrtrpser
1510
<210>353
<211>16
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-2h
<400>353
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>354
<211>12
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-3h
<400>354
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>355
<211>11
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-1l
<400>355
argalaserglnaspileargasnaspleugly
1510
<210>356
<211>7
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-2l
<400>356
alaalaserargleuglnser
15
<210>357
<211>9
<212>prt
<213>artificial
<220>
<223>u1-21-cdr-3l
<400>357
leuglnhisasnsertyrprotrpthr
15
<210>358
<211>12
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-1h
<400>358
glyglyserileserserglyasptyrtyrtrpser
1510
<210>359
<211>16
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-2h
<400>359
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>360
<211>12
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-3h
<400>360
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>361
<211>11
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-1l
<400>361
argalaserglnglyileargasnaspleugly
1510
<210>362
<211>7
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-2l
<400>362
alaalaserserleuglnasn
15
<210>363
<211>9
<212>prt
<213>artificial
<220>
<223>u1-22-cdr-3l
<400>363
leuglnhisasnsertyrprotrpthr
15
<210>364
<211>12
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-1h
<400>364
glyglyserileserserglyasptyrtyrtrpser
1510
<210>365
<211>16
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-2h
<400>365
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>366
<211>12
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-3h
<400>366
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>367
<211>11
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-1l
<400>367
argalaserglnglyileargasnaspleugly
1510
<210>368
<211>7
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-2l
<400>368
alaalaserserleuglnser
15
<210>369
<211>9
<212>prt
<213>artificial
<220>
<223>u1-23-cdr-3l
<400>369
leuglnhisasnsertyrprotrpthr
15
<210>370
<211>12
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-1h
<400>370
glyglyserileserserglyasptyrtyrtrpser
1510
<210>371
<211>16
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-2h
<400>371
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>372
<211>12
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-3h
<400>372
alaasptyraspphetrpasnglytyrpheasptyr
1510
<210>373
<211>11
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-1l
<400>373
argalaserglnglyileargasnaspleugly
1510
<210>374
<211>7
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-2l
<400>374
alaalaserserleuglnser
15
<210>375
<211>9
<212>prt
<213>artificial
<220>
<223>u1-24-cdr-3l
<400>375
leuglnhisasnasntyrprotrpthr
15
<210>376
<211>12
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-1h
<400>376
glyglyserileserserglyasptyrtyrtrpser
1510
<210>377
<211>16
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-2h
<400>377
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>378
<211>12
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-3h
<400>378
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>379
<211>11
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-1l
<400>379
argalaserglnglyileargasnaspleugly
1510
<210>380
<211>7
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-2l
<400>380
alaalaserserleuglnasn
15
<210>381
<211>9
<212>prt
<213>artificial
<220>
<223>u1-25-cdr-3l
<400>381
leuglnhisasnsertyrprotrpthr
15
<210>382
<211>12
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-1h
<400>382
glyglyserileserserglyasptyrtyrtrpser
1510
<210>383
<211>16
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-2h
<400>383
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>384
<211>12
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-3h
<400>384
alaasptyraspphetrpserglytyrpheaspphe
1510
<210>385
<211>11
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-1l
<400>385
argalaserglnglyileargasnaspleugly
1510
<210>386
<211>7
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-2l
<400>386
alaalaserserleuglnser
15
<210>387
<211>9
<212>prt
<213>artificial
<220>
<223>u1-26-cdr-3l
<400>387
leuglnhisasnglytyrprotrpthr
15
<210>388
<211>12
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-1h
<400>388
glyglyserileserserglyasptyrtyrtrpser
1510
<210>389
<211>16
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-2h
<400>389
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>390
<211>12
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-3h
<400>390
alaasptyraspphetrpserglytyrpheaspphe
1510
<210>391
<211>11
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-1l
<400>391
argalaserglnglyileargasnaspleugly
1510
<210>392
<211>7
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-2l
<400>392
alaalaserserleuglnser
15
<210>393
<211>9
<212>prt
<213>artificial
<220>
<223>u1-27-cdr-3l
<400>393
leuglnhisasnglytyrprotrpthr
15
<210>394
<211>12
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-1h
<400>394
glyglyserileserserglyasptyrtyrtrpser
1510
<210>395
<211>16
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-2h
<400>395
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>396
<211>12
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-1l
<400>396
alaasptyraspphetrpserglytyrpheaspser
1510
<210>397
<211>11
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-1l
<400>397
argalaserglnglyileargasnaspleugly
1510
<210>398
<211>7
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-2l
<400>398
alaalaserserleuglnser
15
<210>399
<211>9
<212>prt
<213>artificial
<220>
<223>u1-28-cdr-3l
<400>399
leuglnhisasnglytyrprotrpthr
15
<210>400
<211>10
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-1h
<400>400
glyphethrpheasnsertyraspmethis
1510
<210>401
<211>17
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-2h
<400>401
valiletrptyraspglyserasnlystyrtyralaaspservallys
151015
gly
<210>402
<211>17
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-3h
<400>402
aspargleucysthrasnglyvalcystyrgluasptyrglymetasp
151015
val
<210>403
<211>11
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-1l
<400>403
glnalaserglnaspileserasntyrleuasn
1510
<210>404
<211>7
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-2l
<400>404
aspalaserasnleugluthr
15
<210>405
<211>9
<212>prt
<213>artificial
<220>
<223>u1-29-cdr-3l
<400>405
glnhistyraspthrleuproleuthr
15
<210>406
<211>12
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-1h
<400>406
glyglyserileserserglyasptyrtyrtrpser
1510
<210>407
<211>16
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-2h
<400>407
tyriletyrtyrserglythrthrtyrtyrasnproserleulysser
151015
<210>408
<211>12
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-3h
<400>408
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>409
<211>11
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-1l
<400>409
argalaglyglnglyileargasnaspleugly
1510
<210>410
<211>7
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-2l
<400>410
alaalaserserleuglnser
15
<210>411
<211>9
<212>prt
<213>artificial
<220>
<223>u1-30-cdr-3l
<400>411
leuglnhisasnsertyrprotrpthr
15
<210>412
<211>10
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-1h
<400>412
glytyrthrphethrasntyrglyileser
1510
<210>413
<211>17
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-2h
<400>413
trpileseralatyraspglytyrargasntyralaglnlysleugln
151015
gly
<210>414
<211>13
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-3h
<400>414
aspvalglnasptyrglyasptyrasptyrpheasptyr
1510
<210>415
<211>11
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-1l
<400>415
argalaserglnserilesersertyrleuasn
1510
<210>416
<211>7
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-2l
<400>416
alaalaserserleuglnser
15
<210>417
<211>9
<212>prt
<213>artificial
<220>
<223>u1-31-cdr-3l
<400>417
glnglnsertyrserthrproilethr
15
<210>418
<211>12
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-1h
<400>418
glyglyserileserserglyasptyrtyrtrpser
1510
<210>419
<211>16
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-2h
<400>419
tyriletyrtyrserglythrthrtyrtyrasnproserleulysser
151015
<210>420
<211>12
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-3h
<400>420
alaasptyraspphetrpserglytyrpheasptyr
1510
<210>421
<211>11
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-1l
<400>421
argalaglyglnglyileargasnaspleugly
1510
<210>422
<211>7
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-2l
<400>422
alaalaserserleuglnser
15
<210>423
<211>9
<212>prt
<213>artificial
<220>
<223>u1-32-cdr-3l
<400>423
leuglnhisasnsertyrprotrpthr
15
<210>424
<211>12
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-1h
<400>424
glyglyserileserserglyasptyrtyrtrpser
1510
<210>425
<211>16
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-2h
<400>425
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>426
<211>12
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-3h
<400>426
alaasptyraspphetrpserglyhispheaspcys
1510
<210>427
<211>11
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-1l
<400>427
argalaserglnglyileargaspaspleugly
1510
<210>428
<211>7
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-2l
<400>428
alagluserserleuglnser
15
<210>429
<211>9
<212>prt
<213>artificial
<220>
<223>u1-33-cdr-3l
<400>429
leuglnhishissertyrprotrpthr
15
<210>430
<211>10
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-1h
<400>430
glytyrthrphethrasntyrglyileser
1510
<210>431
<211>17
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-2h
<400>431
trpileseralatyraspglytyrargasntyralaglnlysleugln
151015
gly
<210>432
<211>13
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-3h
<400>432
aspvalglnasptyrglyasptyrasptyrpheasptyr
1510
<210>433
<211>11
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-1l
<400>433
argalaserglnserilesersertyrleuasn
1510
<210>434
<211>7
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-2l
<400>434
alaalaserserleuglnser
15
<210>435
<211>9
<212>prt
<213>artificial
<220>
<223>u1-34-cdr-3l
<400>435
glnglnsertyrserthrproilethr
15
<210>436
<211>10
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-1h
<400>436
glyphethrpheserasptyrtyrmetser
1510
<210>437
<211>17
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-2h
<400>437
tyrileserserserglyasnasniletyrhisalaaspservallys
151015
gly
<210>438
<211>14
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-3h
<400>438
gluargtyrserglytyraspaspproaspglypheaspile
1510
<210>439
<211>11
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-1l
<400>439
glnalaserglnaspileserasntyrleuser
1510
<210>440
<211>7
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-2l
<400>440
aspalaserasnleugluthr
15
<210>441
<211>9
<212>prt
<213>artificial
<220>
<223>u1-35-cdr-3l
<400>441
glnglntyraspasnproprocysser
15
<210>442
<211>12
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-1h
<400>442
glyglyserileserserglytyrtyrtyrtrpser
1510
<210>443
<211>16
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-2h
<400>443
tyriletyrtyrserglythrthrtyrtyrasnproserphelysser
151015
<210>444
<211>12
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-3h
<400>444
alaasptyraspphetrpserglyhispheasptyr
1510
<210>445
<211>11
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-1l
<400>445
argalaserglnglyileargasnaspleugly
1510
<210>446
<211>7
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-2l
<400>446
alaalaserserleuglnser
15
<210>447
<211>9
<212>prt
<213>artificial
<220>
<223>u1-36-cdr-3l
<400>447
leuglnhisasnsertyrprotrpthr
15
<210>448
<211>10
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-1h
<400>448
glytyrthrphethrsertyrglyileser
1510
<210>449
<211>17
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-2h
<400>449
trpileseralatyraspglyhisthrasntyralaglnlysleugln
151015
gly
<210>450
<211>13
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-3h
<400>450
aspprohisasptyrserasntyrglualapheaspphe
1510
<210>451
<211>11
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-1l
<400>451
argalaserglnserilesersertyrleuasn
1510
<210>452
<211>7
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-2l
<400>452
alaalaserserleuglnser
15
<210>453
<211>9
<212>prt
<213>artificial
<220>
<223>u1-37-cdr-3l
<400>453
glnglnsertyrserthrproilethr
15
<210>454
<211>12
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-1h
<400>454
glypheserleuserthrserglyvalglyvalgly
1510
<210>455
<211>16
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-2h
<400>455
leuiletyrtrpasnaspasplysargtyrserproserleulysser
151015
<210>456
<211>9
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-3h
<400>456
argaspgluvalargglypheasptyr
15
<210>457
<211>16
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-1l
<400>457
argserserglnserleuvaltyrseraspglytyrthrtyrleuhis
151015
<210>458
<211>7
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-2l
<400>458
lysvalserasntrpaspser
15
<210>459
<211>9
<212>prt
<213>artificial
<220>
<223>u1-38-cdr-3l
<400>459
metglnglyalahistrpproilethr
15
<210>460
<211>10
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-1h
<400>460
glyphethrvalserserasntyrmetser
1510
<210>461
<211>16
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-2h
<400>461
valiletyrserglyglyserthrtyrtyralaaspservallysgly
151015
<210>462
<211>6
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-3h
<400>462
glyglntrpleuaspval
15
<210>463
<211>16
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-1l
<400>463
argserserglnserleuleuhisserasnglytyrasntyrleuasp
151015
<210>464
<211>7
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-2l
<400>464
leuglyphehisargalaser
15
<210>465
<211>9
<212>prt
<213>artificial
<220>
<223>u1-39-cdr-3l
<400>465
argglnalaleuglnthrproleuthr
15
<210>466
<211>12
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-1h
<400>466
glyglyserileserserglyglytyrtyrtrpser
1510
<210>467
<211>16
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-2h
<400>467
tyriletyrserserglyserthrtyrtyrasnproserleulysser
151015
<210>468
<211>15
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-3h
<400>468
asparggluleugluleutyrtyrtyrtyrtyrglymetaspval
151015
<210>469
<211>16
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-1l
<400>469
argserserglnserleuleutyrserasnglytyrasntyrleuasp
151015
<210>470
<211>7
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-2l
<400>470
leuglyserasnargalaser
15
<210>471
<211>9
<212>prt
<213>artificial
<220>
<223>u1-40-cdr-3l
<400>471
metglnalaleuglnthrproleuthr
15
<210>472
<211>12
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-1h
<400>472
glyglyserileserserglyglytyrtyrtrpser
1510
<210>473
<211>16
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-2h
<400>473
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>474
<211>15
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-3h
<400>474
asparggluleugluglytyrserasntyrtyrglyvalaspval
151015
<210>475
<211>11
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-1l
<400>475
argalaserglnalaileserasntyrleuasn
1510
<210>476
<211>7
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-2l
<400>476
alaalaserserleuglnser
15
<210>477
<211>9
<212>prt
<213>artificial
<220>
<223>u1-41-cdr-3l
<400>477
glnglnasnasnserleuproilethr
15
<210>478
<211>10
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-1h
<400>478
glytyrserphethrsertyrtrpilegly
1510
<210>479
<211>17
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-2h
<400>479
ileiletyrproglyaspseraspthrargtyrserproserphegln
151015
gly
<210>480
<211>9
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-3h
<400>480
hisgluasntyrglyasptyrasntyr
15
<210>481
<211>11
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-1l
<400>481
argalaserglnserileargsertyrleuasn
1510
<210>482
<211>7
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-2l
<400>482
alaalaserserleuglnser
15
<210>483
<211>9
<212>prt
<213>artificial
<220>
<223>u1-42-cdr-3l
<400>483
glnglnserasnglyserproleuthr
15
<210>484
<211>12
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-1h
<400>484
glyglyserileserserglyglytyrtyrtrpser
1510
<210>485
<211>16
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-2h
<400>485
tyriletyrtyrserglyserthrtyrtyrasnproserleuargser
151015
<210>486
<211>17
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-3h
<400>486
asparggluargglutrpaspasptyrglyaspproglnglymetasp
151015
val
<210>487
<211>11
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-1l
<400>487
argalaserglnserilesersertyrleuhis
1510
<210>488
<211>7
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-2l
<400>488
alaalaserserleuglnser
15
<210>489
<211>9
<212>prt
<213>artificial
<220>
<223>u1-43-cdr-3l
<400>489
glnglnsertyrserasnproleuthr
15
<210>490
<211>10
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-1h
<400>490
glytyrserphethrsertyrtrpilegly
1510
<210>491
<211>17
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-2h
<400>491
ileiletrpproglyaspseraspthriletyrserproserphegln
151015
gly
<210>492
<211>9
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-3h
<400>492
hisgluasntyrglyasptyrasntyr
15
<210>493
<211>11
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-1l
<400>493
argalaserglnserileargsertyrleuasn
1510
<210>494
<211>7
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-2l
<400>494
alaalaserserleuglnser
15
<210>495
<211>9
<212>prt
<213>artificial
<220>
<223>u1-44-cdr-3l
<400>495
glnglnserileserserproleuthr
15
<210>496
<211>10
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-1h
<400>496
glytyrthrphethrsertyraspileasn
1510
<210>497
<211>17
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-2h
<400>497
trpmetasnproasnserglyaspthrglytyralaglnvalphegln
151015
gly
<210>498
<211>16
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-3h
<400>498
pheglyaspleuprotyrasptyrsertyrtyrglutrppheasppro
151015
<210>499
<211>11
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-1l
<400>499
argalaserglnserilesersertyrleuasn
1510
<210>500
<211>7
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-2l
<400>500
alaalaserserleuglnser
15
<210>501
<211>9
<212>prt
<213>artificial
<220>
<223>u1-45-cdr-3l
<400>501
glnglnsertyrserthrproleuthr
15
<210>502
<211>12
<212>prt
<213>artificial
<220>
<223>u1-46-cdr-1h
<400>502
glyaspservalserserasnseralaalatrpasn
1510
<210>503
<211>18
<212>prt
<213>artificial
<220>
<223>u1-46-cdr-2h
<400>503
argthrtyrtyrargserlystrptyrasnasptyralavalserval
151015
lysser
<210>504
<211>17
<212>prt
<213>artificial
<220>
<223>u1-46-cdr-3h
<400>504
aspleutyraspphetrpserglytyrprotyrtyrtyrglymetasp
151015
val
<210>505
<211>12
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-1h
<400>505
glyaspservalserserasnseralaalatrpasn
1510
<210>506
<211>18
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-2h
<400>506
argthrtyrtyrargserlystrptyrasnasptyralavalserval
151015
lysser
<210>507
<211>16
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-3h
<400>507
asptyrtyrglyserglyserphetyrtyrtyrtyrglymetaspval
151015
<210>508
<211>11
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-1l
<400>508
argalaserglnserilesersertyrleuasn
1510
<210>509
<211>7
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-2l
<400>509
alaalaserasnleuglnser
15
<210>510
<211>9
<212>prt
<213>artificial
<220>
<223>u1-47-cdr-3l
<400>510
glnglnsertyrserthrproargthr
15
<210>511
<211>10
<212>prt
<213>artificial
<220>
<223>u1-48-cdr-1h
<400>511
glyglyserilesersertyrtyrtrpser
1510
<210>512
<211>16
<212>prt
<213>artificial
<220>
<223>u1-48-cdr-2h
<400>512
hisiletyrthrserglyserthrasntyrasnproserleulysser
151015
<210>513
<211>16
<212>prt
<213>artificial
<220>
<223>u1-48-cdr-3h
<400>513
glualailepheglyvalglyprotyrtyrtyrtyrglymetaspval
151015
<210>514
<211>10
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-1h
<400>514
glytyrthrphethrglytyrtyrmethis
1510
<210>515
<211>17
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-2h
<400>515
trpileasnproasnileglyglythrasncysalaglnlysphegln
151015
gly
<210>516
<211>17
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-3h
<400>516
glyglyargtyrsersersertrpsertyrtyrtyrtyrglymetasp
151015
val
<210>517
<211>16
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-1l
<400>517
lysserserglnserleuleuleuseraspglyglythrtyrleutyr
151015
<210>518
<211>7
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-2l
<400>518
gluvalserasnargpheser
15
<210>519
<211>9
<212>prt
<213>artificial
<220>
<223>u1-49-cdr-3l
<400>519
metglnsermetglnleuproilethr
15
<210>520
<211>12
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-1h
<400>520
glyglyservalserserglyglytyrtyrtrpser
1510
<210>521
<211>16
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-2h
<400>521
tyriletyrtyrserglyserthrasntyrasnproserleulysser
151015
<210>522
<211>17
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-3h
<400>522
glyglyaspserasntyrgluasptyrtyrtyrtyrtyrglymetasp
151015
val
<210>523
<211>11
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-1l
<400>523
argalaserglnserileseriletyrleuhis
1510
<210>524
<211>7
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-2l
<400>524
alaalaserserleuglnser
15
<210>525
<211>9
<212>prt
<213>artificial
<220>
<223>u1-50-cdr-3l
<400>525
glnglnsertyrthrserproilethr
15
<210>526
<211>10
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-1h
<400>526
glyglyserilesersertyrtyrtrpser
1510
<210>527
<211>16
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-2h
<400>527
tyriletyrtyrserglyserthrasntyrasnproserleulysser
151015
<210>528
<211>19
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-3h
<400>528
aspsersertyrtyraspserserglytyrtyrleutyrtyrtyrala
151015
metaspval
<210>529
<211>17
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-1l
<400>529
lysserserglnservalleutyrserserasnasnlysasntyrleu
151015
ala
<210>530
<211>7
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-2l
<400>530
trpalaserthrarggluser
15
<210>531
<211>9
<212>prt
<213>artificial
<220>
<223>u1-51-cdr-3l
<400>531
glnglntyrtyrthrthrproleuthr
15
<210>532
<211>12
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-1h
<400>532
glyglyserileserserglyglytyrtyrtrpser
1510
<210>533
<211>16
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-2h
<400>533
asniletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>534
<211>15
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-3h
<400>534
glyglythrglythrasntyrtyrtyrtyrtyrglymetaspval
151015
<210>535
<211>12
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-1l
<400>535
argalaserglnservalsersersertyrleuala
1510
<210>536
<211>7
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-2l
<400>536
glyalasersertrpalathr
15
<210>537
<211>9
<212>prt
<213>artificial
<220>
<223>u1-52-cdr-3l
<400>537
glnglntyrglyserserproleuthr
15
<210>538
<211>10
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-1h
<400>538
glyphethrpheseriletyrsermetasn
1510
<210>539
<211>17
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-2h
<400>539
tyrileserserserserserthriletyrtyralaaspservallys
151015
gly
<210>540
<211>10
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-3h
<400>540
aspargglyasppheaspalapheaspile
1510
<210>541
<211>11
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-1l
<400>541
glnalaserglnaspilethrasntyrleuasn
1510
<210>542
<211>7
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-2l
<400>542
aspalaserasnleugluthr
15
<210>543
<211>9
<212>prt
<213>artificial
<220>
<223>u1-53-cdr-3l
<400>543
glnglncysgluasnpheproilethr
15
<210>544
<211>12
<212>prt
<213>artificial
<220>
<223>u1-55.1-cdr-1h
<400>544
glyglyservalserserglyglytyrtyrtrpasn
1510
<210>545
<211>16
<212>prt
<213>artificial
<220>
<223>u1-55.1-cdr-2h
<400>545
tyrileasntyrserglyserthrasntyrasnproserleulysser
151015
<210>546
<211>15
<212>prt
<213>artificial
<220>
<223>u1-55.1-cdr-3h
<400>546
asparggluleugluleutyrtyrtyrtyrtyrglymetaspval
151015
<210>547
<211>16
<212>prt
<213>artificial
<220>
<223>u1-55-cdr-1l
<400>547
argserserglnserleuleutyrserasnglytyrlystyrleuasp
151015
<210>548
<211>7
<212>prt
<213>artificial
<220>
<223>u1-55-cdr-2l
<400>548
leuglyserasnargalaser
15
<210>549
<211>9
<212>prt
<213>artificial
<220>
<223>u1-55-cdr-3l
<400>549
metglnalaleuglnthrproilethr
15
<210>550
<211>16
<212>prt
<213>artificial
<220>
<223>u1-57.1-cdr-1l
<400>550
argserserglnserleuleutyrserasnglytyrlystyrleuasp
151015
<210>551
<211>7
<212>prt
<213>artificial
<220>
<223>u1-57.1-cdr-2l
<400>551
leuglyserasnargalaser
15
<210>552
<211>9
<212>prt
<213>artificial
<220>
<223>u1-57.1-cdr-3l
<400>552
metglnalaleuglnthrproilethr
15
<210>553
<211>12
<212>prt
<213>artificial
<220>
<223>u1-57_cdr-1h
<400>553
glyglyservalserserglyglytyrtyrtrpasn
1510
<210>554
<211>16
<212>prt
<213>artificial
<220>
<223>u1-57_cdr-2h
<400>554
tyrileasntyrserglyserthrasntyrasnproserleulysser
151015
<210>555
<211>15
<212>prt
<213>artificial
<220>
<223>u1-57_cdr-3h
<400>555
asparggluleugluleutyrtyrtyrtyrtyrglymetaspval
151015
<210>556
<211>10
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-1h
<400>556
glyphethrphesersertyrglymethis
1510
<210>557
<211>17
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-2h
<400>557
valiletrptyraspglyserasnlystyrtyralaaspservallys
151015
gly
<210>558
<211>12
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-3h
<400>558
alaalaargleuasptyrtyrtyrglymetaspval
1510
<210>559
<211>11
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-1l
<400>559
argalaserglnserileasnsertyrleuasn
1510
<210>560
<211>7
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-2l
<400>560
glyalaserglyleuglnser
15
<210>561
<211>9
<212>prt
<213>artificial
<220>
<223>u1-58-cdr-3l
<400>561
glnglnsertyrserserproleuthr
15
<210>562
<211>10
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-1h
<400>562
glyglyserpheserglytyrtyrtrpser
1510
<210>563
<211>16
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-2h
<400>563
gluileasnhisserglyserthrasntyrasnproserleulysser
151015
<210>564
<211>9
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-3h
<400>564
asplystrpthrtrptyrpheaspleu
15
<210>565
<211>17
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-1l
<400>565
argserserglnservalleutyrserserserasnargasntyrleu
151015
ala
<210>566
<211>7
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-2l
<400>566
trpalaserthrarggluser
15
<210>567
<211>9
<212>prt
<213>artificial
<220>
<223>u1-59-cdr-3l
<400>567
glnglntyrtyrserthrproargthr
15
<210>568
<211>12
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-1h
<400>568
glyvalserileserserglyglytyrtyrtrpser
1510
<210>569
<211>16
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-2h
<400>569
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>570
<211>16
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-3h
<400>570
aspsergluserglutyrserserserserasntyrglymetaspval
151015
<210>571
<211>11
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-1l
<400>571
argalaserglnthrilesersertyrleuasn
1510
<210>572
<211>7
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-2l
<400>572
alaalaserserleuglngly
15
<210>573
<211>9
<212>prt
<213>artificial
<220>
<223>u1-61.1-cdr-3l
<400>573
glnglnsertyrserasnproleuthr
15
<210>574
<211>12
<212>prt
<213>artificial
<220>
<223>u1-61-cdr-1h
<400>574
glyvalserileserserglyglytyrtyrtrpser
1510
<210>575
<211>16
<212>prt
<213>artificial
<220>
<223>u1-61-cdr-2h
<400>575
tyriletyrtyrserglyserthrtyrtyrasnproserleulysser
151015
<210>576
<211>16
<212>prt
<213>artificial
<220>
<223>u1-61-cdr-3h
<400>576
aspsergluserglutyrserserserserasntyrglymetaspval
151015
<210>577
<211>10
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-1h
<400>577
glytyrserphethrsertyrtrpilegly
1510
<210>578
<211>17
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-2h
<400>578
ileiletyrproglyaspseraspthrargtyrserproserphegln
151015
gly
<210>579
<211>12
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-3h
<400>579
glnmetalaglyasntyrtyrtyrglymetaspval
1510
<210>580
<211>12
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-1l
<400>580
argalaserglnservalileseriletyrleuala
1510
<210>581
<211>7
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-2l
<400>581
glyalaserserargalathr
15
<210>582
<211>9
<212>prt
<213>artificial
<220>
<223>u1-62-cdr-3l
<400>582
glnglntyrglyserserprocysser
15