1)Human telomerase reverse transcriptase人类端粒酶催化亚单位
1.Background & Objective:Human telomerase reverse transcriptase (hTERT) is a limiting component for telomerase activity.背景与目的:人类端粒酶催化亚单位(humantelomerasereversetranscriptase,hTERT)基因是端粒酶活化唯一的限制性组分。
2.Objective Human telomerase reverse transcriptase (hTERT) is a rate-limiting enzyme which dictates the activity of human telomerase and thus decides the life span of cells.目的骨髓人类端粒酶催化亚单位(hTERT)是控制人细胞端粒酶活性的限速成分,决定了细胞寿命。
2)human telomerase reverse transcriptase mRNA人端粒酶催化亚单位mRNA
3)hTERT人端粒酶催化亚单位
1.Hammerhead ribozyme against human telomerase catalytic subunit (hTERT) induced apoptosis of liver cancer cells;人端粒酶催化亚单位锤头状核酶诱导肝癌细胞凋亡的作用
2.Objective To clone sequence of hTERT promoter and study its transcriptional activity and its relationship with hTERT mRNA expression and telomerase activity in various kinds of human lung cancer cells and normal cells,and to investigate the targeting transcriptional activity of hTERT promoter in tumor cells.目的克隆人端粒酶催化亚单位(hTERT)启动子序列片段,并探讨hTERT启动子在肿瘤细胞中的靶向转录活性。
3.Objective To investigate the effect of human telomerase reverse transcriptase(hTERT) in the(immortalization) of human neural stem cells(NSCs).目的明确外源性人端粒酶催化亚单位(hTERT)在人神经干细胞永生化过程中的作用。
英文短句/例句
1.Study on pharmacokinetics and acute toxicity of human telomerase reverse transcriptase antisense oligonucleotide molecular probe人端粒酶催化亚单位反义分子探针的药代动力学与急性毒性研究
2.An Experimental Study of hTERT Promoter on Targeting Therapy for Lung Cancer with Suicide Gene HSV-TK;人端粒酶催化亚单位启动子调控自杀基因HSV-TK靶向性表达治疗肺癌的实验研究
3.Uptake kinetics of hTERT antisense molecular probe by cells and its biological properities人端粒酶催化亚单位(hTERT)反义分子探针细胞摄取动力学与生物学性质
4.Expression and Regulation of Telomerase Reverse Transcriptase (hTERT) in Human Lymphocytes From Normal Individuals;不同年龄正常人外周血淋巴细胞端粒酶催化亚单位的表达及调控
5.Expression of Human Telomerase Reverse Transcriptase and c-myc in Osteosarcoma;端粒酶催化亚单位和c-myc在骨肉瘤中的表达
6.Induction of Anti-tumor Immunity Using a Dendritic Cell-targeting Adenovirus Encoding Telomerase Reverse Transcriptase;端粒酶催化亚单位重组腺病毒疫苗的抗肿瘤作用的实验研究
7.Expression of Telomerase Reverse Transcriptase and Its Relationship with Expression of c-myc in Laryngeal Squamous Cell Carcinomas;端粒酶催化亚单位与c-myc在喉鳞癌组织中的表达及意义
8.Study on the Diagnostic Value of Telomerase Activity and hTERT in Pleural Effusions;胸腔积液端粒酶活性和催化亚单位检测的诊断价值研究
9.Correlation of hTERT single nucleotide polymorphism with susceptibility to esophageal carcinoma端粒酶催化亚单位Ex2-659A/G多态性与食管癌易感性的研究
10.Mechanisms and Biological Significances of the Regulation of hTERT Nucleolar Localization;端粒酶催化亚基核仁定位的调控机制及其生物学意义研究
11.Effect of siRNA Targeting the Subunit of Telomerase on Hepatocellular Carcinoma;端粒酶亚单位的siRNA对肝癌的作用
12.Treatment of Endometrial Cancer Cells in Vitro and in Vivo with Antisense Oligodeoxynucleotides of Human Telomerase Reverse Transcriptase Gene;人端粒酶催化亚基反义寡核酸抑制子宫内膜癌的实验研究
13.Influence on SGC-7901 Cell Proliferation and Telomerase Activity by Stably RNAi hTERT and TRAP Gene;稳定干扰端粒酶催化亚基及转录因子对SGC-7901细胞增殖和端粒酶活性的影响
14.Optimization of Antisense Drug Design by Constructing a WEB Based Bioinformatic Analysis System Targeting against Telomerase Reverse Transcriptase mRNA Researches;依据远程WEB生物信息平台靶向设计人端粒酶催化亚基反义寡核苷酸药物的研究
15.Clone and sequence analysis of telomerase reverse transcriptase gene from Giardia canis犬贾第虫端粒酶催化亚基基因的克隆及序列分析
16.Therapeutic Effects of Antisense-hTERTcDNA on Ovarian Cancer Mediated by Retroviral Vector in Vivo;病毒载体介导端粒酶催化亚基反义基因治疗卵巢癌的研究
17.The Effect of ELE on Telomerase Activity and Telomerase Catalytic Subunit hTERT in Hela Cell;榄香烯对Hela细胞端粒酶活性及对hTERT催化亚基的影响
18.Study of Telomerase Activity and Its Subunits in Brain Gliomas;脑胶质瘤端粒酶活性表达及其亚单位基因表达的研究
相关短句/例句
human telomerase reverse transcriptase mRNA人端粒酶催化亚单位mRNA
3)hTERT人端粒酶催化亚单位
1.Hammerhead ribozyme against human telomerase catalytic subunit (hTERT) induced apoptosis of liver cancer cells;人端粒酶催化亚单位锤头状核酶诱导肝癌细胞凋亡的作用
2.Objective To clone sequence of hTERT promoter and study its transcriptional activity and its relationship with hTERT mRNA expression and telomerase activity in various kinds of human lung cancer cells and normal cells,and to investigate the targeting transcriptional activity of hTERT promoter in tumor cells.目的克隆人端粒酶催化亚单位(hTERT)启动子序列片段,并探讨hTERT启动子在肿瘤细胞中的靶向转录活性。
3.Objective To investigate the effect of human telomerase reverse transcriptase(hTERT) in the(immortalization) of human neural stem cells(NSCs).目的明确外源性人端粒酶催化亚单位(hTERT)在人神经干细胞永生化过程中的作用。
4)Human telomerase reverse transcriptase人端粒酶催化亚单位
1.AIM: To construct the sense and antisense eukaryotic expressing vector of human telomerase reverse transcriptase (hTERT) and then test its expression in human embryonic fibroblast (hEFs).目的 :构建人端粒酶催化亚单位 (hTERT)正、反义荧光真核表达载体 ,并检测其在人胚胎成纤维细胞中的表达 。
5)hTERT (human telomerase-reverse transcriptase)人端粒酶逆转录酶催化亚单位(hTERT)
6)telomerase catalytic subunit端粒酶催化亚单位
1.Effect of elemene emulsion on gene expression of telomerase catalytic subunit in HeLa cell;榄香烯对HeLa细胞端粒酶催化亚单位基因表达的作用
延伸阅读
端粒酶分子式：CAS号：性质：一种以逆转录的方式合成真核细胞中线性染色体端粒DNA的特殊酶。该酶的辅基为一特定的RNA，端粒DNA的合成必须依赖酶分子中的辅基RNA为模板，通过逆转录而完成，其自身携带RNA作为产物的模板是区别于一般由纯蛋白组成的逆转录DNA聚合酶的主要特征。在逆转录时需要一个DNA引物，以便从5′→3′方向添加端粒的重复序列。底物是脱氧核苷三磷酸(dNTPs)。如在四膜虫(tetraphymena)中，四膜虫端粒酶催化反应式如下：染色体-GGGGTTGGGGTT(DNA引物)+4ndGTP(dNTPs)+2nTTP(dNTPs)→染色体-GGGGTTGGGGTT(GGGGTT)n(四膜虫端粒DNA)+6n焦磷酸端粒酶的活性在胚系细胞、癌化细胞中活跃；在体细胞，尤其经多次分裂后的体细胞，其活性降低。该酶的活性也可能是多细胞器官限制其细胞增殖的一种机制之一。
