1)HMGB1高迁移率族蛋白1
1.Expression and Clinical Significances of HMGB1 and EGFr vⅢ in Breast Cancer;高迁移率族蛋白1及生长因子受体Ⅲ在乳腺癌组织中的表达及其临床意义
2.Effect of HMGB1 on endothelial cells in sepsis高迁移率族蛋白1在脓毒症血管内皮细胞激活过程中的作用
3.Objective To detect the expression of HMGB1 in the serum and sputum of the patients with chronic cor pulmonale at high altitude area.目的探讨高原慢性肺心病患者血液中高迁移率族蛋白1(high mobility group box1,HMGB1)变化及与痰液中相关因子的关系。
英文短句/例句
1.Expression of High Mobility Group Box 1 in Murine Lupus Nephritis;高迁移率族蛋白1在小鼠狼疮性肾炎中的表达
2.Cloning, Expression and Functional Study of the Human High Mobility Group Box 1 Protein;人高迁移率族蛋白1的克隆、表达及其功能研究
3.Spectroscopic Study on the Interaction of Heparin with High Mobility Group Protein 1肝素与高迁移率族蛋白1相互作用的光谱研究
4.Translocation and Release of HMGB1 in Hepatocytes during Hepatic Failure肝衰竭时肝细胞高迁移率族蛋白1的移位及释放研究
5.Expression of High Mobility Group Box-1 Protein-mRNA in Patients with Chronic Hepatitis B and Its Clinical Significance;慢性乙型肝炎患者高迁移率族蛋白1-mRNA的表达及其临床意义
6.The Study of Qing Huo Bai Du Yin Affect the Expression of High Mobility Group Box Chromosomal Protein 1 in Macrophage;清火败毒饮调理巨噬细胞高迁移率族蛋白1表达的研究
7.Expression of the Human High Mobility Group-1 Protein Gene and Preliminary Studying on Biological Functions of the Recombinant Protein;人高迁移率族蛋白1基因的表达及其生物学功能的初步研究
8.The Expression and Clinical Significance of HMGB1 in Patients with HIV Infection/AIDSHIV感染者/AIDS病人高迁移率族蛋白1的表达及其临床意义
9.High mobility group box chromosomal protein 1 promotes IL-18 production and IL-18 receptor expression in macrophages高迁移率族蛋白1促进巨噬细胞表达IL-18及其受体
10.Effect of HMGB1 on endothelial cells in sepsis高迁移率族蛋白1在脓毒症血管内皮细胞激活过程中的作用
11.High mobility group box-1 stimulates proinflammatory cytokine production in endothelial cells via MAP kinases丝裂原活化的蛋白激酶在高迁移率族蛋白1诱导内皮细胞释放炎性细胞因子中的作用
12.Mouse high mobility group box chromosomal protein1 gene cDNA clone,prokaryotic expression and identification小鼠高迁移率族蛋白1cDNA克隆、原核表达与鉴定
13.HMGB1 Effects on Changes in Apoptosis of PMN in LPS-induced Acute Lung Injury;高迁移率族蛋白1在内毒素急性肺损伤中性粒细胞凋亡改变中的作用探讨
14.The Regulation of Alpha-melanocyte Stimulating Hormone and Its Analogues on the High Mobility Group Box-1 and Its Receptor;Alpha-黑素细胞刺激素及其类似物对高迁移率族蛋白1及其受体表达的调控作用
15.The Effects of Simvastatin on the Expression of HMGB-1 in Atherosclerotic Rats辛伐他汀干预下对大鼠动脉粥样硬化斑块内高迁移率族蛋白1表达的影响
16.Correlation of Serum High-mobility Group Box Protein 1 Level with Defense-Qi-nutrient-blood Syndrome Differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ Score in Sepsis Patients脓毒症患者高迁移率族蛋白1水平与卫气营血辨证、APACHEⅡ评分的相关性研究
17.High Mobility Group Box-1 Protein Inhibition and Liver Function Protection of Ulinastatin in Patients Underwent Hepatoectomy乌司他丁抑制肝切除术后高迁移率族蛋白1的释放及对肝功能的保护作用
18.Influence of High Mobility Group Box 1 on Migration of Human Cord Blood CD34~+ Cells高迁移率族蛋白B1对人脐血CD34~+细胞迁移的影响
相关短句/例句
High mobility group box-1 protein高迁移率族蛋白1
1.AIM To investigate the clinical significance of high mobility group box-1 protein (HMGB1) in chronic hepatitis B and the relationship between HMGB1 and lipopolysaccharide (LPS), tumor necrosis factor-α(TNF-α), serum total bilirubin (TBIL) or prothrombin activity (PTA) respectively.目的本研究旨通过检测慢性乙型肝炎患者外周血单个核细胞(PBMCs)高迁移率族蛋白1(high mobility group box-1 protein,HMGB1)—mRNA的表达水平、外周血浆内毒素(LPS)、肿瘤坏死因子-α(TNF-α)的水平,来探讨HMGB1在慢性乙型肝炎中的临床意义及其与LPS、TNF-α、总胆红素(TBIL)、凝血酶原活动度(PTA)等的关系。
2.High mobility group box-1 protein (HMGB1), which was first discovered as a nuclear protein with rapid electrophoretic migration, is a 30 kDa, nonhistone, DNA-binding molecule that is highly conserved: it has a 99% sequence identity across mammalian species.高迁移率族蛋白1 (high mobility group box protein 1 ,HMGB1)是高迁移率族蛋白中的一种,因其在聚丙烯酰胺凝胶电泳中迁移率快而得名。
3)High mobility group box 1高迁移率族蛋白1
4)High mobility group box chromosomal protein 1高迁移率族蛋白1
1.High mobility group box chromosomal protein 1(HMGB1) is originally identified as a DNA-binding protein that functions as a structural co-factor.目的:高迁移率族蛋白1(HMGB1)是细胞核内典型的非组蛋白。
2.Objective:To investigate whether high mobility group box chromosomal protein 1(HMGB1) can activate macrophages to secrete IL-18.目的:探讨高迁移率族蛋白1(HMGB1)能否激活巨噬细胞表达IL-18及其受体。
5)High mobility group protein 1高迁移率族蛋白质1
6)High mobility group box chromosomal protein 1高迁移率族蛋白-1
1.Objective: To investigate the release and intracellular localization of high mobility group box chromosomal protein 1 (HMGB1) in peripheral blood monocytes of rheumatoid arthritis (RA) patients and the effect of thalidomide on them.目的探讨类风湿关节炎(rheumatoid arthritis,RA)患者外周血单核细胞(peripheral blood monocytes)中高迁移率族蛋白-1(highmobility group box chromosomal protein 1,HMGB 1)的释放和细胞内定位及沙利度胺(Thalidomide,商品名:反应停)对其的影响。
延伸阅读
高迁移率蛋白质分子式:CAS号:性质:真核生物细胞核内的一组含量丰富的染色质非组蛋白。分子中含有25%碱性氨基酸和30%酸性氨基酸,分子量一般小于30 000。由于其在聚丙烯酰胺凝胶电泳中迁移率高而得名。从不同核酸酶选择性地水解有转录活性的染色质的实验中,发现HMG1和HMG2结合在链节DNA上,而HMG14和HMG17常与核小体核心部分的组蛋白八聚体和DNA结合。认为前者在链节处取代组蛋白亚基H1,后者则作用于核小体的核心颗粒,使之修饰成对DNase I等核酸酶更敏感的转录活性染色质,对基因表达起调控作用。荧光免疫法发现,细胞S期的HMG含量高于丝裂期。HMG14和HMG17还可用作亲和层析配体,分离有转录活性的染色质。
