1)HMG-CoA reductaseHMG-CoA还原酶
1.Increase of copy number of HMG-CoA reductase and FPP synthase genes improves the amorpha-4,11-diene production in engineered yeast;HMG-CoA还原酶和FPP合酶基因拷贝数对紫穗槐-4,11-二烯酵母工程菌产量的影响
2.Effect of atorvastatin on HMG-CoA reductase expression in spontaneously hypertensive rats;阿托伐他汀对自发性高血压大鼠HMG-CoA还原酶表达的影响
3.Objective To explore the effects of the one-week swimming with different loads on the gene expressions of HMG-CoA reductase,LDL-R,SR-BI and StAR in Leydig cells of rats with exercise-induced low serum testosterone.方法:大鼠在经过5周间歇性负重游泳训练(TA组),造成运动性血睾酮降低的基础上,停训1周(TB组),继续训练1周:维持原负荷(负重5%体重,1组/日,TC组)、负荷量加倍(负重5%体重,2组/日,TD组)、负荷强度增加(负重6%体重,1组/日,TE组),检测大鼠Leydig细胞胆固醇代谢关键环节上的HMG-CoA还原酶、LDL-R、SR-BI及StAR mRNA表达。
英文短句/例句
1.Hyperexpression of Low-Density Lipoprotein Receptors and Hydroxy-Methylglutaryl Coenzyme A-Reductase in Human Pterygium;人翼状胬肉HMG-CoA还原酶和LDL-R基因表达
2.The establishment of virtual screening models for the discovery of HMG-CoA reductase inhibitorsHMG-CoA还原酶抑制剂的虚拟筛选模型的建立
3.Cloning, Functional Expression, and Expressional Regulation of the Ganoderma Lucidum Hydroxymethylglutaryl-Coenzyme a Reductase Gene;灵芝HMG-CoA还原酶(HMGR)基因的克隆、功能验证及表达调控的初步研究
4.3D-QSAR study of HMG-CoA reductase inhibitors:based on molecules docking and superimposion of FlexSHMG-CoA还原酶抑制剂的3D-QSAR研究:基于分子对接和FlexS的叠合
5.Relationship between HMG-CoA recuctase gene polymorphism and lipid level in Alzheimer's disease阿尔茨海默病患者HMG-CoA还原酶基因多态性与血脂关系的研究
6.Effect of Fenglasu on the expression of HMG-CoA reductase mRNA and protein in HepG_2 cells蜂蜡素对HepG_2细胞HMG-CoA还原酶mRNA表达及蛋白质水平的影响
7.Expression of low-density lipoprotein receptors and hydroxy methylglutaryl-coenzyme A-reductase in human pterygium人翼状胬肉组织HMG-CoA还原酶和LDL受体基因的表达
8.The association of HMG-CoA reductase gene single nucleotide polymorphisms with coronary heart diseaseHMG-CoA还原酶基因单核苷酸多态性与冠心病的关系
9.Study of Hypolipidemic Mechanisms and Efficacy of the Compound Prescription of FTZ Based on the HMG-CoA Reductase复方贞术调脂方基于HMG-CoA还原酶的降脂作用机制及药效物质基础研究
10.reductase deficiency5α-还原酶缺乏症
11.acyl-CoA reductase脂肪酰辅酶A还原酶
12.Nitrate reductase is a short-lived enzyme.硝酸还原酶是短寿酶。
13.Review on the Research of the Relation Between Acetyl CoA Carboxylase and Fatty Acid Metabolism;乙酰CoA羧化酶与运动和饮食减肥关系研究现况
14.Characterization and functional analysis of pXT166 gene in Brassica napus油菜脂酰CoA合成酶基因pXT166的鉴定和功能分析
15.Expression of α-methylacyl-CoA-racemase in breast cancer and its significanceα-甲酰-CoA消旋酶在乳腺癌中的表达及其意义
16.nitrate reductase inhibitor硝酸盐还原酶抑制剂
17.Reduction of nitro phenols catalyzed by nitroreductase硝基还原酶催化还原硝基苯酚的研究
18.An enzyme that catalyzes an oxidation-reduction reaction.氧化还原酶催化氧化还原反应的一种酶
相关短句/例句
HMG CoA reductaseHMG-CoA还原酶
3)HMG CoA reductase mRNAHMG-CoA还原酶mRNA
4)HMG-CoA reductase (HMGCR) geneHMG-CoA还原酶基因
5)HMG-CoA reductase inhibitorHMG-CoA还原酶抑制剂
1.Synthesis and biological evaluation of condensed pyrrole-based HMG-CoA reductase inhibitors;吡咯类HMG-CoA还原酶抑制剂的合成及生物活性
2.A three-dimensional pharmacophore model of 3-hydro-3-methyl glutaryl coenzyme A (HMG-CoA)reductase inhibitors (RI) was developed based on 21 HMG-CoA reductase inhibitors from a rat liver.利用Catalyst计算HMG-CoA还原酶抑制剂最优药效团由一个氢键受体,一个氢键给体,一个疏水基团和一个芳香环特征组成。
3.Pitavastatin is a novel,fully synthetic HMG-CoA reductase inhibitor,which can significantly reduce low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),and also increase high-density lipoprotein cholesterol(HDL-C).匹伐他汀(pitavastatin)是新一代HMG-CoA还原酶抑制剂,能显著降低低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)及升高高密度脂蛋白胆固醇(HDL-C),药动学性质优良,具有肝细胞选择性,且毒性低,安全性好,具有抗动脉粥样硬化、促血管生成和抗炎作用。
6)HMG-CoA reductase inhibitorsHMG-CoA还原酶抑制剂
1.Aim To seek and design new kinds of HMG-CoA reductase inhibitors.目的寻找和设计新的HMG-CoA还原酶抑制剂。
2.By using TLC and UV-spectrum detection,HMG-CoA reductase inhibitors produced by a strain of Monacus sp were assayed,and the optimum fermentation conditions were studied as well.采用薄层层析-紫外吸收光谱法对一株红曲霉产生的HMG-CoA还原酶抑制剂进行分析测定,并对其发酵条件进行研究。
3.Author discussed the impacts of different reference structures on building a pharmacophore model of HMG-CoA reductase inhibitors using DIStance COmparison method (DISCO).目的:考察不同模板分子对距离比较法(DIStance COmparison,DISCO)构建HMG-CoA还原酶抑制剂药效团模型的影响。
延伸阅读
Hmgcoa还原酶hmgcoa还原酶(hmgcoareductase)是合成胆固醇的限速酶,存在于小胞体膜,催化合成甲基二羟戊酸(mevalonicacid),并生成体内多种代谢产物,称之为甲基二羟戊酸途径。细胞内胆固醇水平调节主要依赖于内因性胆固醇合成途径和ldl受体摄取细胞外胆固醇的外因途径两条。goldstein和brown阐明其抑制机制认为,细胞内ch可作为hmgcoa还原酶抑制剂使其活性降低,肝细胞膜上的ldl受体增加,从血中摄取ch也增加,使血中胆固醇水平降低。设想使hmgcoa还原酶活性降低的药物可使血在胆固醇水平下降,尤其是对fh的杂合子患者,凡能使ldl受体数锐减的药物均可起治疗作用。以merinolin的hmgcoa还原酶抑制剂投入,使狗血中ldl消失速度上升,ldl产生速度下降;肝移植的小儿fh纯合子患者,用梅维诺林治疗可使ldl胆固醇降低40%,而ldl产生速度下降35%。这种抑制剂的投入使ldl合成减少的机制,有两种可能,一是胆固醇合成减少使vldl生成量降低;第二是hmgcoa还原酶抑制剂使vldl残粒或β-vldl异化增加,转变成ldl减少。体外抑制实验也证实,从vldl残粒转变到ldl的速度比正常状态下小20倍,与此同时ldl受体的亲和力也增加。
