溶瘤腺病毒,oncolytic adenovirus
1)oncolytic adenovirus溶瘤腺病毒
1.Effects of oncolytic adenovirus H101 treatment on tumor tissue of nude mice transplanted with human esophageal carcinoma cells induced by carcinoembryonic antigen gene silencing癌胚抗原基因抑制对溶瘤腺病毒H101治疗人食管癌裸鼠皮下移植瘤的影响
2.To reduce the killing effect of oncolytic adenovirus on normal cells and get safe clinical application,oncolytic adenovirus AdCN103,a novel dual-targeting tumor specific proliferating virus,was constructed by replacing the wild type adenovirus E1A promoter with the promoter of human telomerase reverse transonptase(hTERT) and mutant E1A lacking CR2 region.为了降低溶瘤腺病毒对正常细胞的杀伤作用,提高临床应用上的安全性,构建了一种双靶向溶瘤增殖型腺病毒AdCN103,以人端粒酶逆转录酶(hTERT)启动子代替野生型腺病毒E1A自身的启动子,同时在E1A区缺失保守区域CR2的24bp。
3.To develop a novel gene therapeutic oncolytic adenovirus in which the hTERT promoter was introduced and used to regulate adenoviral E1A gene.为构建一种由人端粒酶逆转录酶启动子(hTERTp)调控的能够在肿瘤细胞中特异性增殖的新型肿瘤基因治疗溶瘤腺病毒载体系统,利用基因重组技术将hTERTp插入5型腺病毒E1A基因上游,构建肿瘤特异性增殖腺病毒AdSU,使其携带绿色荧光蛋白报告基因。
英文短句/例句

1.Target Therapy with Oncolytic Adenovirus for Cancer Stem Cell溶瘤腺病毒对肿瘤干细胞的靶向治疗
2.The Research of Anticancer for Replicating Adenovirus Combined with Paclitaxel溶瘤腺病毒AdCN103联合紫杉醇抗癌研究
3.Survivin Promoter Mediated Oncolytic Adenovirus Vector for Cancer TherapySurvivin启动子介导的溶瘤腺病毒载体抗肿瘤研究
4.Antitumor activity of the oncolytic adenovirus SG600-p53 in gastric cancer xenografts in nude mice溶瘤腺病毒SG600-p53对裸鼠胃癌移植瘤的抑制作用
5.Feasibility of Oncolytic Adenovirus Labeled With Radionuclides for Treating Tumors放射性核素标记溶瘤腺病毒治疗肿瘤的可行性
6.Studies on Cancer Therapy by Oncolytic Adenovirus Expressing Cpp-Fused SOCS3;溶瘤腺病毒表达穿膜肽修饰的SOCS3的抗癌研究
7.Construction of IL-18 Expressing Cancer-Specific Replication-Competent Adenoviruses and in Vitro Cytotoxic Effect in Hepatocellular Carcinoma Cells;携带IL-18的复制型溶瘤腺病毒治疗肝癌的研究
8.Construction and Application of a Novel Oncolytic Adenovector System;溶瘤腺病毒载体系统的构建及其功能研究
9.Construction and Characterization of Oncolytic Adenovirus Controlled Under Heat Shock Protein70 Gene Promoter加热调控的溶瘤腺病毒载体构建及其特征研究
10.Effects of Recombinant Human Canstatin Protein and Oncolytic Adenovirus He-Cans in the Treatment of Pancreatic Cancer;重组人Canstatin蛋白及溶瘤腺病毒He-Cans治疗胰腺癌的实验研究
11.Study on Cancer-Specific Replication-Competent Adenoviruses Armed with hTRAIL for Cancer Therapy;携带hTRAIL的复制型溶瘤腺病毒治疗恶性肿瘤的研究
12.Construction and Application of a Newly Oncolytic Adenovirus Vector M3 Selectively Blocking STAT3 of Tumor;选择性封闭肿瘤STAT3的新型溶瘤腺病毒M3的构建及应用
13.Potent Antitumor Efficacy of XAF1 Delivered by Conditionally Replicative Adenovirus Vector via Caspase-Independent Apoptosis;携带XAF1的复制型溶瘤腺病毒治疗恶性肿瘤的研究
14.Construction of conditionally replication-competent adenoviral vectors targeting hepatocarcinoma and their in vitro anti-tumor effect肝癌选择性溶瘤腺病毒的构建及其体外抑瘤作用
15.Construction of conditionally replicating adenovirus expressing staphylococcal enterotoxin A gene表达金黄色葡萄球菌肠毒素A基因的条件增殖型溶瘤腺病毒的构建
16.Preparation of Oncolytic Adenovirus Selectively Killing Hepatocarcinoma Cells;肝癌靶向性溶瘤腺病毒的构建及其对肝癌细胞的特异性杀伤研究
17.Inhibitory Effects of Oncolytic Adenovirus with hTERT Small Interference RNA on Proliferation of Human Cervical Cancer HeLa Cells溶瘤腺病毒介导RNA干扰人端粒酶逆转录酶抑制HeLa细胞生长
18.Killing effect of an GFP-expressing oncolytic adenovirus on colon cancer cells in vitro表达GFP基因的溶瘤腺病毒对大肠癌细胞的体外杀伤作用
相关短句/例句

HCC-specific CRAd溶瘤性腺病毒
3)oncolytic adenovirus vector溶瘤腺病毒载体
1.With the development of gene-virotherapy for cancer, more and more tumor-specific promoters are employed to mediated oncolytic adenovirus vector for tumor selective cytotoxicity.肿瘤特异性启动子用于调控溶瘤腺病毒载体靶向于肿瘤细胞,从而实现对肿瘤组织的特异性杀伤,肿瘤特异性启动子的应用已成为靶向基因病毒治疗中的一个重要策略。
4)Bicistronic adenovirus双顺反子溶瘤腺病毒
5)replicative oncolyitc adenovirus增殖性溶瘤腺病毒
1.ZD55-IL-24 is a replicative oncolyitc adenovirus carrying tumor-specific interleukin-24 gene and targeting tumor cells with loss of p53.增殖性溶瘤腺病毒ZD55-IL-24是靶向p53缺失且携带肿瘤特异性的白细胞介素-24基因(IL-24);丝裂霉素(mitomycin C,MMC)是一种目前临床上癌症治疗常用化疗药物之一。
6)Oncolytic virus溶瘤病毒
1.Oncolytic virus is a kind of virus killing tumor cells with duplication ability,which can duplicate in tumor cells depending on its own specificity and then kill and split the tumor cells.溶瘤病毒是一类具有复制能力的肿瘤杀伤型病毒。
2.Objective:To observe the effectiveness of oncolytic virus H101 combined with chemotherapy in treatment of patients with lymph node metastasis of nasopharyngeal carcinoma, and to discuss the related mechanism.目的:观察溶瘤病毒药物H101联合化疗药物对鼻咽癌淋巴结转移的治疗效果,初步探讨H101的作用机制。
延伸阅读

促肾上腺皮质激素腺瘤促肾上腺皮质激素腺瘤ACTH secreting adenoma,Cushing disease  分泌过多的ACTH导致肾上腺皮质增生而分泌过量的糖皮质激素,造成多种物质代谢紊乱及抵抗力降低,即皮质醇增多症,临床表现为身体向心性肥胖,满月脸、水牛背,多血质、腹部和大腿皮肤有紫纹,毳毛增多等,重者闭经、性欲减退、全身乏力。有的并有高血压、糖尿病等,本症应与其他原因所引起的皮质醇增多症(cushing syndrome)相鉴别,少数肥胖病患者亦可有类似的皮质醇增多的症状,测血浆ACTH及地塞米松试验有助于鉴别诊断。