1)γ-secretaseγ分泌酶
1.Assembly of γ-secretase for production of β-amyloid;催化淀粉样蛋白产生的γ分泌酶的组装
2.Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).膜蛋白presenilin1(PS1)是γ分泌酶的催化组分,是催化产生β淀粉样蛋白(β-amyloid,Aβ)的关键蛋白酶,因此也是治疗阿尔茨海默病(Alzheimer’s disease,AD)的主要靶点。
3.Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.处理超表达组(T)和对照组(C)细胞,并收集纯化过程中含γ分泌酶复合物的样本,用Western blotting检测γ分泌酶复合物重要组分Nicastrin(NCT)、Presenilin-1(PS-1)以及TMP21的蛋白表达量。
英文短句/例句
1.Effect of Overexpressed Transmembrane Protein 21 on Activity of β-secretase Involved in Alzheimer's超表达状态下的TMP21对介导阿尔茨海默氏病γ分泌酶复合物活性影响的研究
2.Design and Synthesis of New γ-Secretase Inhibitors新型γ-分泌酶抑制剂的设计与合成
3.γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cellsγ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖
4.Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;γ-分泌酶组分基因APH-1A和PEN-2的转录调控
5.Regulatory effects of gamma-secretase in neural stem cell differentiationγ-分泌酶在神经干细胞分化过程中的调节作用
6.The Effect of γ-secretase Inhibitor-DAPT on Differentiation and Proliferation of Neural Stem Cells in Rats;γ-分泌酶抑制剂DAPT对神经干细胞增殖分化影响及可能机制
7.Study on the Impact of Transmembrane Protein 21 γ-Secretase Involved in Alzheimer s Disease;跨膜转运蛋白21对引起阿尔茨海默病的γ-分泌酶的作用研究
8.Inhibitor and regulator of presenilin for Alzheimer’s disease治疗阿尔茨海默病的早老素/γ-分泌酶抑制剂和调节剂
9.T-Lymphocytes Immune Function of IFN-Gamma Production from Tuberculous Pleural Effusions Assayed by ELISPOT酶联免疫斑点法检测结核性胸水T淋巴细胞分泌IFN-γ的免疫功能
10.Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect;兼有神经保护作用的γ-分泌酶抑制剂的计算机辅助设计、合成及初步活性实验研究
11.The Expression of Insulin/Insulin Growth Factor-1 and γ-Secretase/β-Amyloid Protein in the Brain Tissues of Mice with Diabetes Mellitus as Well as Its Research MeaningIGF-1/INR与γ-分泌酶/β-淀粉样蛋白在糖尿病大鼠脑组织中的表达及意义
12.Construction of prokaryotic expression vector pFLAG-IFN-γ with mouse secretion type IFN-γ小鼠分泌型γ干扰素原核表达载体pFLAG-IFN-γ的构建
13.Rhizopus secrets this enzyme into the bread.面包酶将这种酶分泌到面包上。
14.Erepsin is secreted by glands in the wall of the small intestine.肠肽酶是由小肠壁的腺体分泌的。
15.Chief cells make and secrete pepsinogen.主细胞制造和分泌胃蛋白酶原。
16.The Effects of Carbon and Nitrogen Sources on Extracellular Laccase Production by Coriolus versicolor;碳、氮源对云芝胞外漆酶分泌的影响
17.Protein kinase Cε and β cell secretion funtion蛋白激酶Cε与胰岛β细胞分泌功能
18.Enzymatic Studies of Oligoxanthan Degraded by Xanthase from Sphingomonas sp. Strain XT-11;黄原胶寡糖酶法制备及水解酶分泌菌株的定性
相关短句/例句
γ-secretaseγ-分泌酶
1.Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
2.Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;γ-分泌酶组分基因APH-1A和PEN-2的转录调控
3.Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.Aβ是由淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶(BACE)和γ-分泌酶水解产生的,因此BACE1在AD的形成过程中发挥重要作用。
3)β-and γ-secretaseβ-和γ-分泌酶
1.Objective To investigate the effects of Chinese herb compound Shen-wu capsule on the metabolism of β-amyloid(Aβ) and β-and γ-secretase in β-amyloid precursor protein(APP) transgenic mice.目的观察中药新复方参乌胶囊对β-淀粉样肽前体蛋白(APP)转基因小鼠脑内β-淀粉样肽(Aβ)代谢及β-和γ-分泌酶的影响。
4)γ-secretase inhibitorsγ-分泌酶抑制剂
1.Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect;兼有神经保护作用的γ-分泌酶抑制剂的计算机辅助设计、合成及初步活性实验研究
2.Methods A series of compounds were designed,synthesized,and evaluated based on pharmacophore model of γ-secretase inhibitors by virtual screening in MDL.目的通过在数据库中虚拟筛选,以期发现新的γ-分泌酶抑制剂。
5)β-or γ-secretaseβ-或γ-分泌酶
6)γ-secretase inhibitorγ分泌酶抑制剂
1.SectionⅠ: The expression and activation of Notch signaling in human breast cancer and the effect ofγ-secretase inhibitor on the proliferation of breast cancerBackground:Notch signaling is a pathway highly conserved through evolution which regulates various physiological processes,including stem cell maintenance, differentiation,proliferation and apoptosis.第一部分乳腺癌标本及乳腺细胞系中Notch信号通路的表达、活化及γ分泌酶抑制剂对乳腺癌细胞增殖的影响研究背景:Notch信号传导通路是在进化过程中高度保守的信号传导系统,由Notch受体和配体组成。
延伸阅读
酒化酶、醇酶、发酵酶分子式:CAS号:性质:又称酒化酶、醇酶、发酵酶。从酵母中分离而得的一系列酶。不耐热。它能催化酒精发酵反应,与糖酵解有关,如磷酸化酶、醛缩酶、葡萄糖磷酸变位酶、葡萄糖6-磷酸酶等。