α分泌酶,α-secretase
1)α-secretaseα分泌酶
1.Effects of 17β-estradiol on α-secretase activity in rat cortical neurons雌二醇对大鼠皮质原代神经元α分泌酶活性的影响
2.Alternatively, APP can also be sequential processed by α-secretaseand γ-secretase, which not only preclude the formation of Aβ, but also generate a l.APP也可在α分泌酶和γ分泌酶的序列作用下水解,既避免了完整Aβ分子的产生,又产生了对细胞有益的胞外片段(sAPPα),因此这条代谢途径已成为研究AD治疗的靶点。
英文短句/例句

1.Effects of 17β-estradiol on α-secretase activity in rat cortical neurons雌二醇对大鼠皮质原代神经元α分泌酶活性的影响
2.An Experimental Study of the Effect of Ginaton on Hippocampal α、β-secretase of Old Rats after Chronic Cerebrohypoperfusion;Egb761对脑慢性低灌注老龄大鼠海马α、β-分泌酶影响的实验研究
3.Modulation of Mast Cell Proteainse Activated Receptor Expression and Th2 Cytokines Release by TNF-α;TNF-α对肥大细胞蛋白酶激活受体表达和介质分泌的影响
4.An experimental study of the effect on α-secretase of rat hippocampal neurons after chronic hypoxic and hypoglycemic culture慢性低氧低糖培养影响新生大鼠海马神经元α-分泌酶的实验研究
5.Rhizopus secrets this enzyme into the bread.面包酶将这种酶分泌到面包上。
6.The Effect of Lactobacillus on Tumor Necrosis Factor-α Secretion of Cells;乳酸杆菌对细胞肿瘤坏死因子-α分泌的影响
7.The Relation of Adherent Endotoxin Ceramic Wear Debris and TNF-α;粘附内毒素陶瓷颗粒与TNF-α分泌相关性研究
8.The Effect of RNA Interference to the Excretion of TNF-α in Stimulated Splenic Lymphocytes;RNA干扰对小鼠脾淋巴细胞分泌TNF-α的影响
9.High-Level Secretory Expression of Po-IFN α in Pichia Pastoris;猪α干扰素基因在毕赤酵母中的分泌表达
10.The Influence of RNA Interference to the Excretion of TNF-α in Mice Spleen Lymphocytes;RNA干扰作用对小鼠脾淋巴细胞分泌TNF-α的影响
11.The Secretive Expression of Procine IFN-α in Yeast Pichia Pastoris;猪α型干扰素基因在毕赤酵母中的分泌表达
12.The Research of Tumor Necrosis Factor-α on RBP4 Secreted by Mature Adipocytes;TNF-α影响成熟脂肪细胞分泌RBP4的相关研究
13.Influence of Radix Rehmanniae Preparata Water Extract on TNF-α Produced by Monocytes of Balb/C Mice熟地黄水提液对小鼠单核细胞分泌TNF-α的影响
14.Erepsin is secreted by glands in the wall of the small intestine.肠肽酶是由小肠壁的腺体分泌的。
15.Chief cells make and secrete pepsinogen.主细胞制造和分泌胃蛋白酶原。
16.The Effects of Carbon and Nitrogen Sources on Extracellular Laccase Production by Coriolus versicolor;碳、氮源对云芝胞外漆酶分泌的影响
17.Design and Synthesis of New γ-Secretase Inhibitors新型γ-分泌酶抑制剂的设计与合成
18.γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cellsγ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖
相关短句/例句

α-secretaseα-分泌酶
1.Experimental study on activity ofα-secretase in PS1 mutational transfected cells;PS1基因突变转染细胞中α-分泌酶活性的实验研究
2.An experimental study of the effect on α-secretase of rat hippocampal neurons after chronic hypoxic and hypoglycemic culture慢性低氧低糖培养影响新生大鼠海马神经元α-分泌酶的实验研究
3)β-secretaseβ-分泌酶
1.β-secretase Interracts with Divalent Cation Tolerant Protein CUTA;β-分泌酶与二价阳离子耐受蛋白CUTA存在相互作用
2.The effect of TO901317 on the expression of β-secretase and β-amyloid peptide in hippocampal neuron;TO901317对海马神经元β-分泌酶表达及β-淀粉样肽生成的影响
3.Cerebral ischemia injury-induced β-amyloid formation in astrocytes associated with increases of β-secretase in rat brain;大鼠缺血性脑损伤致星形神经胶质细胞内β-淀粉样蛋白聚集与β-分泌酶增加相关
4)γ-secretaseγ分泌酶
1.Assembly of γ-secretase for production of β-amyloid;催化淀粉样蛋白产生的γ分泌酶的组装
2.Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).膜蛋白presenilin1(PS1)是γ分泌酶的催化组分,是催化产生β淀粉样蛋白(β-amyloid,Aβ)的关键蛋白酶,因此也是治疗阿尔茨海默病(Alzheimer’s disease,AD)的主要靶点。
3.Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.处理超表达组(T)和对照组(C)细胞,并收集纯化过程中含γ分泌酶复合物的样本,用Western blotting检测γ分泌酶复合物重要组分Nicastrin(NCT)、Presenilin-1(PS-1)以及TMP21的蛋白表达量。
5)β-secretaseβ分泌酶
1.A screen assay of β-secretase inhibitors in vitro;β分泌酶抑制剂体外筛选模型的构建与验证
2.Construction and identification of RNA interfering vector targeting β-secretase;靶向β分泌酶RNA干扰质粒的构建与鉴定
3.New development of β-secretase;酶解淀粉样前体蛋白的β分泌酶研究进展
6)γ-secretaseγ-分泌酶
1.Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
2.Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;γ-分泌酶组分基因APH-1A和PEN-2的转录调控
3.Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.Aβ是由淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶(BACE)和γ-分泌酶水解产生的,因此BACE1在AD的形成过程中发挥重要作用。
延伸阅读

α,α,α,α',α',α'-六氯对二甲苯分子式:C8H4Cl6分子量:312.84CAS号:68-36-0性质:白色针状或粉末状结晶。熔点108-110℃。溶于二甲苯、石油醚、乙醇、植物油,不溶于水。无味,有特殊臭味,遇光、碱会缓慢分解而呈酸性。制备方法:以混二甲苯为原料,先用98%硫酸磺化,使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层,水洗、干燥,减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1,4-双(三氯甲基)苯:在反应锅中投入邻、对二甲苯,再加入过氧化苯甲酰和三乙醇胺。加热到70℃后,在光照射下导入氯气,于70-80℃反应6h,再升温至100-120℃继续反应,至反应液相对密度达到1.560-1.580(65℃),即为反应终点,停止通氯,减压脱除余氯。降温至5℃,过滤,洗涤得粗品,重结晶,活性炭脱色得成品。用途:抗血吸虫病药物。对肝吸虫病、阿米巴原虫病、疟疾以及肠道线虫有一定疗效。但对神经系统的不良反应较多见,且延迟反应持续较久。