1)liver microsomes肝微粒体酶
1.Metabolic kinetics of MN9202 in Beagle dog liver microsomes;MN9202在Beagle犬肝微粒体酶中的代谢动力学
英文短句/例句
1.Effects of 20 Chinese patent medicines on the catalytic activities of five main cytochrome P450s of human liver microsome20味中成药对5个人肝微粒体酶活性的影响
2.Effects of Cryptotanshinone on Cytochrome P450 Isoforms in Rat Liver Microsomes隐丹参酮对大鼠肝微粒体CYP酶的影响
3.Preliminary Study on Microsomal Cytochrome P450 Enzymes in Pigs;猪肝微粒体细胞色素P450酶系的初步研究
4.A Preliminary Study on Hepatic Microsomal Cytochrome P450 in Carassius Auratus;鲫鱼肝微粒体细胞色素P450酶系的初步研究
5.Effects of Several Pesticides on Hepatic Cytochrome P450 in Carassius Auratus;几种农药对鲫鱼肝脏微粒体P450酶系的影响
6.CYP450 Bioactivation of Organnophosphorothioate Pesticides in Fish Liver Misrosomes鱼类肝脏微粒体P450酶对有机磷杀虫剂的代谢
7.Research of Euphorbia Coadministration with Glycyrrhiza Based on Cytochrome P450 in Rat Liver Microsomes;基于大鼠肝脏微粒体细胞色素P450酶系的甘遂和甘草配伍作用研究
8.Research on the Mechanism of Activation of Mice Liver Microsome Glutathione S-Transferase by Drug Treatment;药物对小鼠肝微粒体谷胱甘肽S-转移酶的激活机制研究
9.Influence of Borneolum Syntheticum on Cytochrome Enzymes in Liver Microsome;冰片单次和多次给药对肝脏微粒体药物代谢酶的影响
10.Effects of Simvastatin on Drug-metabolizing Enzyme of Liver Microsome in Rats辛伐他汀对大鼠肝微粒体药物代谢酶活性的影响
11.Responses of CYP450 Isoenzyme in Liver Microsome of Carassius auratus Linn.Under Polybrominated Diphenyl Ethers Stress鲫鱼肝脏微粒体CYP450同工酶对多溴联苯醚胁迫的应答
12.Effects icariin on the contents of liver microsomal cytochrome P450 and the activities of CYP2E1淫羊藿苷对小鼠肝微粒体细胞色素P450酶及其亚型CYP2E1活性的影响
13.Metabolism of enrofloxacin and detection of metabolic enzyme activity in the liver microsome of johnny carp (Carasius auratus gibelio)异育银鲫肝微粒体体外恩诺沙星N-脱乙基酶酶促反应动力学初步研究
14.CHANGES OF HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASE AND PLASMA SEX HORMONE LEVELS IN ADULT THYMECTOMIZED RATS AND AGED RATS成年去胸腺大鼠和老年大鼠肝微粒体混合功能氧化酶及血浆性激素水平的变化
15.Expression and Metabolic Function of the Microsomal Phase Ⅱ Enzymes in the ES Derived Hepatocytes;微粒体Ⅱ相代谢酶在小鼠胚胎干细胞分化肝细胞的表达及其代谢功能研究
16.Preliminary Studies on Metabolism and Impact on Main P450 Isoenzymes of Enrofloxacin in Carasius Auratus Gibelio Liver Microsome恩诺沙星在异育银鲫肝微粒体中代谢及对P450主要亚酶影响的初步研究
17.Metabolism of Ketamine in the Cytochrome P450 of Human Liver Microsomes;氯胺酮在人肝微粒体CYP450系统中的代谢
18.Preliminary Study on Microsomal Cytochrome P450 Enzymes in Chickens;鸡肝微粒体细胞色素P450的初步研究
相关短句/例句
Liver microsome P450 enzyme肝微粒体P450酶
3)liver microsomes肝微粒体
1.CYP3A1/2 and 2C9/10 in rat liver microsomes mediate 22α-and 24-hydroxylation of 18α-glycyrrhetic acid;大鼠肝微粒体CYP3A1/2和CYP2C9/10参与甘草次酸羟化代谢
2.Determination of puerarin in rat liver microsomes by LC-MS and its pharmacokinetics;大鼠肝微粒体中葛根素的液相色谱-质谱测定法及药物代谢动力学
3.Gender difference in ranolazine metabolism in rat liver microsomes;盐酸雷诺嗪在大鼠肝微粒体内代谢的性别差异
4)hepatic microsome肝微粒体
1.Effect of influence on levels of LPO and SOD of hepatic microsome in mice of Yuzhiling;预知灵对小白鼠肝微粒体LPO及SOD活性的影响
2.Cytochrome P450 contents and activity in hepatic microsome of grass carp(Ctenopharyngodon idellus);草鱼肝微粒体的提取及CYP酶活性的测定
5)microsomes肝微粒体
1.Methods Liver microsomes were preparated from normal human liver, which was subjucted to be treated with a series of concentrations of CsA or coadministration with MP.方法在人肝微粒体中单独使用CsA和联用甲基强的松龙,以红霉素为底物,经过NADPH系统孵育后,分别测定肝微粒体的红霉素N-脱甲基酶(ERD)活性。
2.The activities oi CYP3A in the microsomes were detected by using erythromycin as substrate.方法:制备大鼠和人肝微粒体,用不同浓度的CsA作用、加或不加MP、Flu,以红霉素为底物,经过NADPH系统孵育后,利用分光光度法测定人和大鼠肝微粒体的红霉素N-脱甲基酶(ERD)活性。
3.The activities of CYP3A in the microsomes were detected by using erythromycin as substrate.方法：(1)分别制备大鼠和人肝微粒体，加入不同浓度的CsA0μmol／l、10μmol／l、20μmol／l、40μmol／l作用，以红霉素为底物，经过NADPH系统孵育后，利用分光光度法测定人和大鼠肝微粒体的红霉素N-脱甲基酶(ERD)活性。
6)Liver microsome肝微粒体
1.Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes;五味子醇甲在大鼠肝微粒体内的代谢动力学和性别差异
2.Screening of Chinese materia medica possessed inhibitory effect on cytochrome P4502D6 in liver microsomes of rats;应用大鼠肝微粒体筛选对细胞色素P4502D6有抑制作用的中药
3.Study on metabolism of tetramethylpyrazine in system of rat liver microsomes;川芎嗪在大鼠肝微粒体系统中的代谢研究
延伸阅读
肝微粒体药物代谢酶分子式：CAS号：性质：肝脏微粒体中含有多种酶系统,是许多药物、杀虫剂、除草剂、污染物及食物添加剂等外源性高脂溶性物质在体内的主要生物转化场所,也称为肝微粒体药物代谢酶,简称为肝药酶。该酶系统底物面广,活性个体差异大,影响活性因素多。其中最重要的是混合功能氧化酶系统,可催化许多不同型的氧化反应,如羟基化,烷基化,脱氨基化,脱卤素,硫原子氧化等。该酶系统中一个主要成分是细胞色素P450,是由与一氧化碳结合后,在光谱450nm处有吸收峰而得名。细胞色素P450含量高低反映了混合功能氧化酶系统活性的高低,这个系统将分子氧中一个氧原子氧化药物,另一个氧原子生成水,没有产生相应的还原物,故也称为细胞色素单加氧酶。肝药酶主要生物学意义是使大多数药物转化后降低或消失活性,极性增加,易于排出体外。少数药物经生物转化后可产生药理活性,如环磷酰胺,在细胞色素P450催化下氧化成4-羟基环磷酰胺,开环后变成磷酰胺氮芥才有烷化作用。个别药物如非那西丁,经转化生成对氨基苯乙醚,毒性加大。也有少数化合物如多环芳香烃经转化可成为有致癌及致突变的中间体。
