1)selective estrogen receptor modulator选择性雌激素受体调节剂
1.Advances on mechanisms of selective estrogen receptor modulators and their therapy of postmenopausal osteoporosis;选择性雌激素受体调节剂的作用机制及其治疗绝经后骨质疏松症的研究现状
2.AIM: To discuss the influence of selective estrogen receptor modulator(SERM) raloxifene(RAL) on the expression of TNF-α in cancellous bone and bone mineral density (BMD) loss in ovariectomized rats.目的选择性雌激素受体调节剂(SERM)—雷诺昔酚(RAL)对去卵巢大鼠骨密度及松质骨中TNF-α表达的影响。
3.Objective To discuss the influence of selective estrogen receptor modulator(SERM) on Expression of TNF-α in cancellated bone and bone mineral density and the parameters of bone morphometry in ovariectomized rats.目的了解选择性雌激素受体调节剂(SERM)对去卵巢大鼠骨组织形态计量学指标、骨密度及松质骨中TNF-α表达的影响。
英文短句/例句
1.Synthesis of Selective Estrogen Receptor Modulators: Pipendoxifene;选择性雌激素受体调节剂:Pipendoxifene的合成
2.lnfluence of Movement and the Selective Estrogen Receptor Modulator For Postmenopausal Women with Bone Metabolism运动和选择性雌激素受体调节剂结合对绝经后女性骨代谢的影响
3.Objective To synthesize raloxifene hydrochloride, which is a selective estrogen receptor modulator.目的合成选择性雌激素受体调节剂盐酸雷洛昔芬。
4.Studies on Synthesis and Technique of Raloxifien: A Selective Estrogen Receptor Modulator;选择性雌激素受体调节剂雷诺昔芬的合成方法研究
5.Estrogen and Selective Estrogen Receptor Modulators Inhibit Cell Proliferation in Prostate Carcinoma Cell Line PC3 Cells;雌激素和选择性雌激素受体调节剂抑制前列腺癌细胞系PC3生长的实验研究
6.Studies of the Impairing Effects and Mechanism of Action of Selective Estrogen Receptor Modulators on Learning and Memory Function in Mice;选择性雌激素受体调节剂对小鼠学习记忆功能的损伤作用及机理研究
7.Effect of selective estrogen receptor modulators on bone metabolism induced by premature ovarian failure after radiotherapy选择性雌激素受体调节剂对放疗所致卵巢早衰引起骨质丢失的实验研究
8.The study of selective estrogen receptor-β agonist in the treatment of adenomyosis in mice选择性雌激素受体β激动剂治疗小鼠子宫腺肌病的实验研究
9.Problems and countermeasure of screening studies on estrogen receptor modulators in Chinese materia medica中药植物雌激素受体调节剂筛选研究中的问题与对策
10.The selective activation effect of E0703 on different estrogen receptor subtypesE0703对雌激素受体(ER)不同亚型的选择性激活作用
11.Isoflavones Regulate Target Genes Transcription Through Estrogen Receptors;异黄酮类植物雌激素通过雌激素受体对靶基因的转录调节作用
12.Effect of Estrogen Replacement Therapy after Ovariectomy on Expression of Estrogen Receptor α and β in Rat Trabecular Bone;去卵巢后雌激素替代对大鼠松质骨雌激素受体α和β的调节
13.Studies on Functions of New Estrogen Receptor Regulation Factor GA5;新型雌激素受体调节因子GA5的功能研究
14.Research of Function of a Novel Co-regulator of Estrogen Receptor(ER)新型雌激素受体(ER)调节因子蛋白的功能研究
15.Neuroprotective Effects of Prenylflavnoid Estrogen Receptor Modulators and Differentiation Stimulatory Effects on Embryonic Stem Cells into Neurons;异戊烯基黄酮类雌激素受体调节剂的神经保护和促胚胎干细胞分化为神经细胞的研究
16.Expression of estrogen receptor α in female rat's brain雌激素受体α在雌性大鼠脑中的表达
17.Regulatory mechanism in expression of IRS-1 and 2 by estrogen and high concentration of insulin雌激素和高胰岛素调节胰岛素受体底物-1,2表达机制研究
18.Relationship of depression-like behavior induced by chronic restraint stress estrogen and hippocampal estrogen receptor of female mice慢性束缚应激性抑郁与雌性小鼠雌激素和海马雌激素受体的关系
相关短句/例句
selective estrogen receptor modulators选择性雌激素受体调节剂
1.In recent years,advanced research on selective estrogen receptor modulators has been made,making the treatment of menopausal syndrome safer and more effective.近年来,选择性雌激素受体调节剂的研究取得一定进展,将使更年期综合征的治疗更趋安全有效。
2.Selective estrogen receptor modulators(SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen receptor agonists and antagonists.选择性雌激素受体调节剂(SERMs)是一类结构不同的化合物,能与靶器官细胞内的雌激素受体结合而发挥雌激素受体激动剂和拮抗剂的作用。
3.Based on the brief introduction of progress in the development of present anti-AD-drugs, the paper mainly focused on the advances in the field of multi-target-directed drug development both home and abroad, especially those studies on selective estrogen receptor modulators.本文在简要介绍目前抗AD药物开发的基础上,主要阐述国内外多靶向抗AD药物的研究进展,尤其是选择性雌激素受体调节剂在AD多靶向治疗药物方面的研究进展。
3)SERMs选择性雌激素受体调节剂
1.Selective estrogen receptor modulators(SERMs) are kinds of compounds that exert different biological effects on ER in different tissues and can be used in the tr.选择性雌激素受体调节剂是一类在不同的组织细胞中对雌激素受体发挥不同调节作用的化合物,用于治疗绝经后妇女的骨质疏松和乳腺癌等。
4)selective estrogen receptor modulators(SERMs)选择性雌激素受体调节剂
1.Two major types of antiestrogenic agents are structurally categorized as selective estrogen receptor modulators(SERMs)and pure antiestrogens.抗雌激素药物主要包括选择性雌激素受体调节剂(SERMs)和纯抗雌激素剂。
5)SERM选择性雌激素受体调节剂
1.Selective estrogen receptor modulators (SERMs) are a class of compounds that can act as estrogen receptor (ER) agonists in some tissues and at the same time as ER antagonists in others.分类综述近年来非甾体类选择性雌激素受体调节剂(SERMs)的研究与开发,其中包括三苯乙烯类、苯并噻吩类、吲哚类、萘类、苯并吡喃类、呋喃类、吡唑类、四环类等。
6)Selective estrin receptor modulator (SERM)选择性雌激素受体调节剂(SERM)
延伸阅读
雌激素受体雌激素受体 雌激素受体属类固醇类受体,纯化的受体相对分子质量为65000,第322~395位氨基酸为雌激素结合区,调控雌激素受体基因位于X性染色体,雌激素受体基因在第6对染色体,分A、B、C、D、E、F 6个区,C和E区分别为DNA和配基结合区。雌激素受体在羧基末端有配基结合区,其组成的氨基酸与雌激素、孕激素受体的配基结合区有许多相似性。其功能除与相应配基结合外,还具有二聚体化和核定位的功能。雌激素受体是一种酸性蛋白质,不溶于30%的硫酸铵溶液,对热极不稳定,未结合的受体比游离受体复合物更敏感。它不仅存在于细胞浆,也存在胞核内。其生物学特性为结合容量低、高亲和力、特异性强和组织特异性,如子宫、乳腺、阴道的性激素受体含量较非靶组织器官要高得多,目前已证实,骨骼、心脏、肌肉和大脑等组织均存在雌激素受体。在正常月经周期中,子宫内膜ER和PR呈周期性变化,增生期因E2的升调节作用逐渐增加,到增生晚期达高峰,分泌期因P的降调节作用ER和PR则下降。在病理情况下,ER含量会发生明显变化。