1)hydrolytic kinetic resolution水解动力学拆分
1.L-(–)-Carnitine was synthesized from epichlorohydrin by selective hydrolytic kinetic resolution with chiral salen-CoIII complexes to give (S)-(+)-epichlorohydrin, which was subjected to quaternarization, cyanidation, hydrolysis and then ionic exchange with an overall yield of about 70% based on (S)-(+)-epichlorohydrin.以自制手性salen-CoⅢ为催化剂,水解动力学拆分外消旋环氧氯丙烷,得到高光学纯度的(S)-(+)-环氧氯丙烷,再经季胺化、氰化、水解及离子交换制得L-(–)-肉碱,总收率70%[以(S)-(+)-环氧氯丙烷计]。
2.The hydrolytic kinetic resolution (HKR) of racemic terminal epoxides catalyzed by chiral (salen)Co could afford optically active terminal epoxides.用手性 (Salen)Co催化剂催化的外消旋末端环氧化合物的水解动力学拆分反应所得的手性末端环氧化合物和各种取代的胺和烷氧负离子反应 ,可得到光学纯的 β 胺基醇和 β 烷氧基醇类化合物 ,这两类化合物是重要的生物活性分子 。
3.Chiral Salen reacted with cobalt acetate and oxidized to give the Salen-Co(III) complex (S,S)-2, which catalyzes the hydrolytic kinetic resolution of racemic epoxides to afford chiral epoxides and diols in good yield with the e.将 (S ,S) 1,2 二苯基乙二胺 (DPEDA)与 2 羟基 5 甲基 3 叔丁基苯甲醛缩合 ,得到手性Salen ,再与Co络合 ,氧化后得到Salen Co(III)手性催化剂 ,用于催化外消旋环氧化合物的水解动力学拆分 ,得到了光学活性的环氧化合物和二醇 ,产率较高 ,对映体过量 2 0 。
英文短句/例句
1.Design, Synthesis and Application of Hydrolytic Kinetic Resolution Catalysts水解动力学拆分末端环氧化合物催化剂的设计、合成及应用
2.Enzymatic Ammonolysis of Ethyl 4-chloro-3-hydroxybutanoate in Organic Solvents;有机相酶催化氨解反应拆分4-氯-3-羟基丁酸乙酯及其动力学研究
3.Efficient Kinetic Resolution of Terminal Epoxides with Phthalimide Using Chiral Salen(Co)(OAc)手性Salen(Co)(OAc)催化胺解动力学拆分外消旋末端的环氧化物
4.Dynamic Kinetic Resolution Reactions of Azlactones Catalyzed by Organocatalysts;有机小分子催化吖内酯动态动力学拆分反应
5.Dynamic Kinetic Resolution via Asymmetric Transfer Hydrogenation Reaction不对称氢转移反应诱导动态动力学拆分
6.Enzymatic Resolution of γ-Lactones and Dynamic Kinetic Resolution of α-Branched Aldehydes by Using Asymmetric Transfer Hydrogenation Reaction;γ-内酯的酶法动力学拆分以及α-支链醛的不对称氢转移动态动力学拆分
7.Resolution of Alpha-Cyano-Benzyl Acetate Via Lipase-Catalyzed Asymmetric Alcoholysis in Organic Media;有机相酶催化不对称醇解反应拆分α-氰基苄醇乙酯及其反应动力学研究
8.Synthesis and Thermal Decomposition Kinetics of Hydrated Strontium Borate水合硼酸锶的制备及脱水热分解动力学
9.Recent advancement of the dynamic thermodynamic resolution of chiral compounds手性化合物的动态热力学拆分研究进展
10.Preparation of Spherical TiO_2 and Kinetics of Its Hydrolysis Process水解制备球形TiO_2及其水解过程动力学
11.Molecular Dynamics Simulation of Methane Hydrate Dissociation Process in the Presence of Thermodynamic Inhibitor热力学抑制剂作用下甲烷水合物分解过程的分子动力学模拟
12.Kinetics of Monosaccharide Decomposition in High Temperature Liquid Water;高温液态水中单糖分解反应动力学研究
13.Decomposition Kinetics of Glucose in High Temperature Liquid Water;高温液态水中葡萄糖分解反应动力学研究
14.Molecular Dynamics Simulations of Water and Electrolyte Solutions水及电解质溶液的分子动力学模拟研究
15.Research on the Kinetics of Gas Hydrate Decomposition in Porous Media多孔介质中气体水合物的分解动力学研究现状
16.Thermogravimetric Characteristics and Kinetic Analysis of Lignin Hydrolyzed by Dilute Acid稀酸水解木素的热失重特性及其动力学分析
17.Degradation Kinetics of Azadirachtin A and Its Homologues with the Influence of Water水分影响印楝素及同系物降解动力学研究
18.Decomposition kinetics of salvianolic acid B's aqueous solution丹酚酸B水溶液分解反应的动力学研究
相关短句/例句
kinetic resolution动力学拆分
1.Bulk liquid membrane (BLM) containing D-(+)-dibenzoyltartaric acid (D-(+)-DBTA) as chiral carrier was used for the resolution of racemic clenbuterol, the optimal chiral extraction conditions and the kinetic resolution model were established.以D-(+)-二苯甲酰酒石酸(D-(+)-DBTA)为流动载体,研究了克伦特罗(clenbuterol,Cle)对映体的厚体液膜法拆分,建立了手性拆分条件和动力学拆分模型。
2.While a great progress was achieved in the domain of enzymatic kinetic resolution during the past years, non-enzymatic kinetic resolution is becoming another current hot area, which mainly refers to enanti-oselective acylation, oxidation, reduction, ring-opening, ring-closing, substitution and addition, etc.动力学拆分是合成光学纯化合物的重要方法之一。
3.Kinetic resolution is the most widely used method in the production of enantiomer pure ketoprofen.介绍了生产酮洛芬单一对映体常用的动力学拆分法及该工艺过程存在的不足。
3)resolution kinetics拆分动力学
1.The factors influencing the enantioselectivity of enzyme catalyzed asymmetric transformations in organic phase, and the enzymatic resolution kinetics are discussed.总结了有机溶剂中的酶催化研究进展，讨论了影响有机溶剂中酶促不对称转化过程对映体选择性的因素和拆分动力学。
4)dynamic kinetic resolution动态动力学拆分
1.The dynamic kinetic resolution (DKR) of racemic compounds provides one of the most convenient and efficient routes to a wide range of enantiomerically enriched molecules.动态动力学拆分是合成具有光学活性化合物最方便和最有效的方法之一。
2.Dynamic kinetic resolution (DKR) has extended the scope of methodology for preparation of enantiopure compounds.动态动力学拆分扩展了制备单一手性化合物的工艺方法。
3.The methods of kinetic resolution,dynamic kinetic resolution and enantioconvergence resolution were compared with each other.系统地综述了酶法手性拆分技术的最新研究和应用进展,对动力学拆分、动态动力学拆分和对映体收敛转化3种方法进行了比较,并介绍了酶,尤其是脂肪酶在非水介质中催化酯和氨基化合物的立体选择性水解、转酯化和酰胺化的研究进展及其在技术上遇到的问题和解决方法。
5)hydrolysis resolution水解拆分
6)parallel kinetic resolution平行动力学拆分
延伸阅读
动力学拆分分子式：CAS号：性质：外消旋体与一手性试剂(包括酶)反应时，它们的过渡态是非对映的，具有不同的活化能。如果反应是不可逆地进行，则具有低活化能的反应是主反应，成为主要产物。当用不足量的手性试剂与外消旋体反应，则其中一个对映体优先与手性试剂反应生成产物，而余下的是富集的另一对映体，这就是动力学拆分。如下式所示。(±)-A+(+)-B(不足量)→(-)-A·(+)-B+(+)-A
