1)Collagen-induced arthritis胶原诱导性关节炎
1.Inhibition of sinomenine on nuclear factor-κB of synoviocytes in collagen-induced arthritis rats;青藤碱对胶原诱导性关节炎大鼠滑膜细胞NF-κB的抑制作用
2.OBJECTIE:To isolate and purify collagen typeⅡ(CⅡ) and establish the rat model of collagen-induced arthritis(CIA).目的:在鸡胸骨剑突软骨中提取、纯化Ⅱ型胶原蛋白(CⅡ)并进行初步鉴定,为制备胶原诱导性关节炎(CIA)大鼠模型提供原材料;制备CIA大鼠模型,从形态学、免疫学及病理组织学等多角度观察CIA大鼠模型特点;进一步阐明CIA大鼠的发病机制。
3.Administration of recombinant or synthetic peptides containing CTE2 can improve the condition of collagen-induced arthritis(CIA) and reduce the anti-CⅡantibody level in serum and synovial fluid.随后进一步的研究发现,CⅡ中真正发挥功能的区域是定位于CⅡ-CB11片段中260-270aa,称为CⅡ耐受原表位2(Collagen tolerogenic epitope 2,CTE2),单独给予包含该表位的化学合成或基因重组的多肽能够对胶原诱导性关节炎(Collagen-induced arthritis,CIA)症状起到缓解作用,并能显著降低血清及关节液中抗CⅡ抗体水平。
英文短句/例句
1.Anti-inflammatory effect and mechanisms of lovastatin in rats with collagen-induced arthritis洛伐他汀对胶原诱导性关节炎大鼠的抗炎机制探讨
2.Effect of Chromones from Saposhnikovia Divaricata on Collagen-induced Arthritis in Rats防风色原酮提取物对大鼠胶原诱导性关节炎的影响
3.Effect of sinomenine on apoptosis of synoviocytes in CIA rats青藤碱对胶原诱导性关节炎大鼠滑膜细胞凋亡的影响
4.Proteomics Research on Synovitis of Collagen-induced Arthritis (CIA) Rat Treated with Bizhongxiao Decoction (BZXD);痹肿消汤干预胶原诱导性关节炎大鼠滑膜病变的蛋白质组学研究
5.The Cellular and Molecular Immunoregulatory Mechanisms of TongBiLing on Collagen-induced Arthritis;通痹灵抗胶原诱导性关节炎分子免疫学机理探讨
6.Comparative Proteomic Analysis of Collagen-Induced Arthritis (CIA) Rat Synovium Treated with Bizhongxiao Decoction;痹肿消汤干预胶原诱导性关节炎大鼠的差异蛋白质组学分析
7.Effect of Compound Glycyrrhizin Tablets on Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1β(IL-1β)in Serum of Rats with Collagen-induced Arthritis;复方甘草酸苷对胶原诱导性关节炎大鼠血清TNF-α、IL-1β的影响
8.Experimental Study on the Effects of Bikangyin Mixture on the Rats with Type Ⅱ Collagen-induced Arthritis;痹康饮合剂对Ⅱ型胶原诱导性关节炎大鼠治疗机制的实验研究
9.IL-17 Level in Serum and Its Expression in the Synovium of the Collagen Induced Arthritis Rat;IL-17在胶原诱导性关节炎大鼠血清水平及滑膜组织表达
10.Establishment of Rat Collagen-induced Arthritis Model and Evaluation of Interleukin-33 Expression in Synovial Tissue胶原诱导性关节炎大鼠模型建立及其滑膜IL-33的表达
11.Effect of Tripterygium Polyglycosides on the Expression of VEGF mRNA in CIA Rat Tissues雷公藤多苷对胶原诱导性关节炎大鼠组织中VEGF mRNA表达的影响
12.Effects of Bi-Zhong-Xiao Decoction on Annexin-1 expression in synovium of Collagen-Induced Arthritis rat痹肿消汤对胶原诱导性关节炎大鼠滑膜组织Annexin-1表达的影响
13.Effect of extractive from Lapemis Hardwick Ⅱ on serum SOD,T-AOC and MDA levels on rats with type Ⅱ collagen-induced arthritis海蛇提取物对胶原诱导性关节炎大鼠血清SOD、T-AOC和MDA含量的影响
14.Study on Establishing Collagen-induced Arthritis and Adjuvant-induced Arthritis Models in Rats胶原诱导的关节炎和佐剂诱导的关节炎大鼠模型的制备
15.Effects of PGE2 on the Differentiation of Treg/Th17 Cells and Its Significance on the Pathogenesis of Collagen-induced ArthritisPGE2对Treg/Th17细胞分化的调节及对胶原诱导性小鼠关节炎发病的影响
16.Experimental Study of Pentoxifyline on Treatment of Collagen-induced Arthritis in Rats;己酮可可碱治疗胶原诱导性大鼠关节炎的实验研究
17.Experimental Study of Lovastatin and Batroxobin on Treatment of Collagen-induced Arthritis in Rats洛伐他汀及巴曲酶治疗胶原诱导性大鼠关节炎的实验研究
18.Effect of low molecular weight sinomenine on collage induced arthritis model in rat青藤碱对胶原诱导性大鼠关节炎症的影响及其作用机制
相关短句/例句
collagen induced arthritis胶原诱导性关节炎
1.The pathological effect of Qingbi tablet on synovium of rat with collagen induced arthritis;清痹片对胶原诱导性关节炎大鼠滑膜组织病理学改变的影响
2.Objective This study was performed to explore the interleukin( IL )-17 level in serum and expression in synovium, and to analyze the relationship with tumor necrosis factor-α(TNF-α) , joint destruction in the collagen induced arthritis (CIA) rat in different periods, so that we realize the effect of IL-17 on CIA and provide a new method of diagnosis and therapy for rheumatoid arthritis (RA).目的探讨胶原诱导性关节炎(collagen induced arthritis CIA)大鼠不同时期血清IL-17水平及在滑膜组织的表达,及其与同期血清肿瘤坏死因子-α(TNF-α)和最终关节病理破坏的关系,研究IL-17在CIA发病中的作用机制,为类风湿关节炎的早期生物治疗提供线索。
3)collagen induced arthritis(CIA)胶原诱导性关节炎
1.Objective To observe the neuroimmunoregulating effect of vasoactive intestinal peptide(VIP) in ameliorating collagen induced arthritis(CIA), providing an important implication for the clinic therapy of rheumatoid arthritis(RA) with VIP.目的探讨血管活性肠肽(VIP)对胶原诱导性关节炎(CIA)大鼠的免疫调节作用,为应用VIP治疗类风湿关节炎(RA)提供理论依据。
2.Objective To observe the relationship between multiple neuroimmunoregulating effects of β-endorphin(β-END) on collagen induced arthritis(CIA) rats,providing an important implication for the clinic therapy of rheumatoid arthritis(RA) with β-END.目的研究β-内啡肽(β-END)对胶原诱导性关节炎(CIA)大鼠的免疫调节作用,为探索β-END治疗类风湿关节炎(RA)提供实验依据。
4)collagen induced arthritis (CIA)胶原诱导性关节炎
1.ObjectiveTo observe the neuroimmune-regulating effect and molecular mechanism of vasoactive intestinal peptide (VIP), β-endorphin (β-END) ameliorating collagen induced arthritis (CIA), further to explore new promising therapy on rheumatoid arthritis (RA).【目的】 研究血管活性肠肽(vasoactive intestinal peptide，VIP)、β-内啡肽(β-endorphin，β-END)对胶原诱导性关节炎(collagen induced arthritis，CIA)模型的神经-免疫调节作用及其受体依赖的细胞内信号传导途径，为探索两者治疗类风湿关节炎(rheumatoid arthritis，RA)提供实验依据。
5)collagen Ⅱ-induced arthritisⅡ型胶原诱导性关节炎
1.Objective To study the effect of Guizhishaoyaozhimu Decoction(GSZD) on rats with collagen Ⅱ-induced arthritis(CIA) and to discuss the mechanism.目的研究桂枝芍药知母汤对Ⅱ型胶原诱导性关节炎大鼠的治疗作用,并探讨其作用机制。
6)C-II induced arthritis in rats胶原诱导性关节炎大鼠
延伸阅读
尿道炎性关节炎尿道炎性关节炎 病名。亦称Reiter综合征、Fiessinger-Leroy-Reiter综合征、Waelsch综合征、脓溢性特发性关节炎、性病性关节炎、结合膜尿道滑膜综合征、尿道-眼-关节(滑膜)综合征。许多病原体被认为与之有关，如类胸膜炎菌、衣原体、福氏痢疾杆 菌(肠型者)。自身免疫，皮肤病变类似脓疱性牛皮癣，过度角化症，海绵状脓疱。滑膜改变 为非特异性，后期似类风湿性关节炎的损害。男性多见，11～40岁发病。尿道炎：出现最早 ，可能不被注意，也可为严重的痛性排尿、血尿、脓尿。在肠型者尿道炎常轻微。后期发生 环状龟头炎。结合膜炎(50%以上)：在尿道炎开始后10日出现，从轻度充血到化脓性病变， 很少同时有虹膜炎、角膜炎。关节炎(最常见)：对称性，常累及膝、踝、跖及跗关节，很少 为腕关节。关节周围肿胀、皮肤苍白、变热，关节痛，轻度发热，有些病例以腹泻为首发症 状，在2～3周或数年后才相继或同时出现上述“三联症状”，但表现较轻。在患关节炎的同 时或以后发生局部或全身皮肤角化症，口腔黏膜损害。急性期可有血沉加快，X线示早期骨 质疏松、软组织肿胀，后期皮肤侵蚀，新骨形成，关节破坏。治疗用四环素、保泰松、肾上 腺皮质激素，亦可理疗。部分自发缓解，反复发作可引起关节强直。并发症有心肌炎、心包 炎、胸膜炎、主动脉瓣损害、心传导阻滞、肺浸润、青光眼和血栓性静脉炎。
