TLR4,Toll-like receptor 4
1)Toll-like receptor 4TLR4
1.Lipopolysaccharide upregulates the expression of Toll-like receptor 4 in human vascular endothelial cells;内毒素上调血管内皮细胞TLR4m RNA的表达(英文)
2.Upregulated expression of Toll-like receptor 4 in brain tissue surrounding hematoma correlates with neurologic deficits in experimental cerebral hemorrhage miceTLR4在实验性脑出血小鼠脑组织表达变化及其与神经功能缺损的相关性
3.Inflammation signal mediated by lipopolysaccharide ( LPS) is transduced into cells by a transmembrane protein of Toll-like receptor 4(TLR4),resulting in a series of cytological effect.细菌脂多糖(LPS)介导的炎症信号主要通过一种跨膜蛋白toll样受体4(toll-likereceptor4,TLR4)传入胞内,引起一系列相应的细胞效应。
英文短句/例句

1.Studies on the Mechanism of BCL10 in the LPS/TLR4 Signal Pathway;BCL10介导LPS/TLR4信号通路的机制研究
2.Study on the Role of 4-1BB and CD40 Signals in Regulation of TLR4 Expression;4-1BB和CD40信号对TLR4表达调节的研究
3.The Influence of AIRE to Treg Mediated by TLR4 and Notch1AIRE通过TLR4及Notch1对Treg影响的研究
4.Expression of TLR2、TLR4 mRNA in Patients with Atopic Dermatitis特应性皮炎患者皮损中TLR2、TLR4 mRNA的表达
5.Study on relationship between chronic left heart failure and TLR2 and TLR4 in elderly patientsTLR2和TLR4与老年慢性左心衰关系的研究
6.Relativity of TLR4 expression in uroepithelium carcinoma of the bladderTLR4在膀胱尿路上皮癌中的表达及意义
7.Cutaneous Expression of Toll-like Receptor2 and 4 in Various Dermatitis ModelsTLR2和TLR4在不同皮炎模型皮肤的表达
8.Effects of SIGIRR on TLR4 of H292 induced by LPSSIGIRR对LPS诱导的H292细胞TLR4表达的影响
9.Changes of TLR4 and Treg in Severely Burnt Rats and Effects of Forsythia Suspense on Them;严重烫伤大鼠TLR4和Treg的变化及连翘对其影响
10.The Role of PTEN in Regulating LPS Induced TLR4 Signaling Pathway and Its Mechanism;PTEN调控LPS活化TLR4信号通路的作用及机制研究
11.The Effect of Forsythia Suspense on Anti-endotoxin and LPS-TLR4 Signal-transducing Pathway;连翘抗内毒素作用及其对LPS-TLR4信号通路的影响
12.The Expression and the Relationships among TLR4, MBP, GFAP, and PDGFR-α in the Brain of the Premature Rats with Intrauterine Infection;宫内感染早产大鼠脑TLR4、GFAP、MBP、PDGFR-α表达及意义
13.Expression of CD14 and TLR4 in Experimental Pulpitis of Rats Induced by Lipopolysaccaride;CD14、TLR4在LPS诱导的大鼠实验性牙髓炎中的表达
14.Exploration of the Relationship between the Expression of Toll Like Receptor Four and Inflammation during Cardiopulmonary Bypass;TLR4的表达与体外循环术后炎症反应关系的探讨
15.TLR4 Expression in the Monocytes of Hypertensive Left Ventricular Hypertrophy Patients;TLR4在高血压左室肥厚患者单核细胞中的表达
16.Effects of the Inhibition of NF-κB on TLR4 Expression in Left Ventricular Myocyte of Goldblatt Rats;抑制NF-κB对TLR4在Goldblatt鼠左室心肌中表达的影响
17.TLR4 Expression and Its Relevant Factors in Left Ventricular Myocyte of Goldblatt Hypertensive Rats;TLR4在Goldblatt鼠左室心肌中的表达及影响因素
18.Changes of TLR4/MD-2 Receptor Complex in Perioperative Patients and the Expression of MD-2 Protein in E.coli;围手术期TLR4/MD-2的变化及MD-2蛋白的原核表达
相关短句/例句

TLR2,TLR4TLR2、TLR4
3)TLR4 geneTLR4基因
1.In this experiment,a 316 bp and 382 bp fragments of TLR4 gene named T4CRBR1 and T4CRBR2,of Chinese Holstein,Sanhe cattle,and Chinese Simmental was amplified by polymerase chain reaction(PCR),respectively.以中国荷斯坦奶牛、三河牛和中国西门塔尔牛为研究对象,以TLR4为乳房炎抗性的候选基因,分别扩增316bp和382bp2个片段,分别采用SSCP和RFLP-AluⅠ方法来检测TLR4基因的多态性。
2.To detect the DNA variation of bovine TLR4 gene,a 321bp segment of TLR4 gene exon Ⅲ was analyzed by PCR-RFLP.采用PCR-RFLP技术,对奶牛TLR4基因外显子Ⅲ321bp的部分序列进行多态性分析,结果发现扩增产物C到T突变处存在限制性内切酶Bbv12 I酶切位点,并且导致编码氨基酸由苏氨酸变为异亮氨酸。
3.The genetic polymorphisms of TLR4 gene exonⅢwere detected by sequencing in the first and by RFLP in the second.本研究以中国荷斯坦奶牛和新疆褐牛为研究对象,对TLR4基因外显子3进行了序列分析,并对发现的多态性位点进行PCR-RFLP分析,共发现TLR4 E3+1656、TLR4E3+2021和TLR4 E3+2414三个多态位点,其中TLR4 E3+1656位点发生T/C的碱基突变,但没有引起氨基酸变化;TLR4 E3+2021位点C/T的碱基突变,导致编码氨基酸由苏氨酸变为异亮氨酸;TLR4 E+2414位点发生G/A突变,引起氨基酸由精氨酸变为谷氨酸。
4)TLR4 signalingTLR4通路
1.The expression of molecule targets in TLR4 signaling parthway were detected at 5 min,10 min,30 min,1 h,2 h,6 h,12 h,24 h(n = 3) after treatment by Western blotting.方法:将雄性C57BL/6J小鼠随机分为LPS处理组(腹腔注射LPS10mg/kg)和生理盐水对照组,Western blotting检测处理后5min、10min、30min、1h、2h、6h、12h、24h各时间点(n=3)心肌TLR4通路各分子靶点的激活。
5)TLR4-blockedTLR4阻断
6)Toll like receptot-4TLR4受体蛋白
延伸阅读

J基因分子式:CAS号:性质:为免疫球蛋白V区与C区之间的连接区(J区)编码的基因。