1)Hypoxia inducible factor缺氧诱导因子
1.Objective:To investigate the expression of Hypoxia inducible factor-1α(HIF-1α) and inducible Nitric Oxide Synthase (iNOS) in cholesteatoma and approach the possible role of them in the formation and development of the middle ear cholesteatoma.目的:研究缺氧诱导因子-1α(HIF-1α)、诱导型一氧化氮合酶(iNOS)在中耳胆脂瘤上皮中的表达及意义,探讨其在发病机制中的可能作用。
2.To research the relationship between the expression of hypoxia inducible factor - alpha (HIF- α) and vascular endothelial growth factor (VEGF) in drowning rats brain and brain injury caused by freshwater drowning, meanwhile, to investigate the correlation of the two cytokines.探讨溺水后大鼠脑内缺氧诱导因子(HIF-1α)和血管内皮生长因子(VEGF)与溺水脑损伤的关系及两者的相关性。
3.The mutation of von Hipple-Lindau tumor suppressor gene results in the inactivation of pVHL,and abnormal accumulation of hypoxia inducible factor-α(HIF-α),HIF-α regulates the transcription and expression of downstream genes,and promotes tumorigenesis and development of the clear cell renal cell carcinoma(CCRCC)through stimulating angiogenesis and cell proliferation.肿瘤抑制基因vonHipple-Lindau(简称VHL基因)的突变失活导致肿瘤细胞中缺氧诱导因子的累积,进而调节其下游靶基因的转录和表达,促进肿瘤内新生血管形成及细胞增殖,从而促进肾透明细胞癌的发生、发展。
英文短句/例句
1.The Effects of Hypoixa-Inducible Factor-1a on Gastric Cancer During Hypoixa;缺氧诱导因子-1α对缺氧胃癌细胞的影响
2.Cardioprotection role of hypoxia-inducible factor-1缺氧诱导因子-1在心肌保护中的作用
3.RESEARCH PROGRESS OF HYPOXIA INDUCIBLE FACTOR 1α IN HYPOXIC-ISCHEMIC INJURY缺氧诱导因子1α在缺氧缺血性损伤中的研究进展
4.Protective role of hypoxia inducible factor-1 in cultured cardiocytes with hypoxia/reoxygenation缺氧诱导因子-1对心肌细胞缺氧/复氧损伤的保护作用
5.Gene Cloning of Hypoxia-inducible Factor-1α and Expression Research of HIF-1α-pcDNA3.1;缺氧诱导因子1α基因克隆及HIF-1α-pcDNA3.1表达研究
6.Correlation of hypoxia inducible factor 1-α polymorphism and nasopharyngeal carcinoma缺氧诱导因子-1α基因多态性与鼻咽癌的关系
7.Research Progress on the Relationship between Hypoxia-Inducible Factor-1 and Preeclampsia缺氧诱导因子1与子痫前期相关性研究进展
8.Study on the Roles of HIFs and Their Target Genes in Chemical Hypoxia Preconditioning Protection;缺氧诱导因子及其调节基因在化学缺氧预处理保护中的作用研究
9.The Effects of Ischemic Preconditioning on the Expression of Hypoxia Inducible Factor-1α Gene in Ischemic Myocardium;缺血预处理对缺血心肌缺氧诱导因子-1α基因表达的影响
10.Study of Hypoxia-inducible Factor-1α on Carcinogenesis of Esophageal Squamous Cell Cancer;缺氧诱导因子1α在食管鳞癌发病机制中的研究
11.Experimental Research in Targeting Hypoxia-inducible Factor-1α for Pancreatic Cancer Therapy;缺氧诱导因子-1α在胰腺癌中的靶向治疗研究
12.The Influence of Hypoxia Inducible Factor 2 Alpha on the Biological Behaviour of Hepatocellular Carcinoma Cells;缺氧诱导因子2α对肝癌细胞生物学行为的影响
13.Research of Hypoxia Inducible Factor-1α in Benign Prostatic Hyperplasia;缺氧诱导因子-1α与良性前列腺增生的研究
14.Activity and Mechanism of Hypoxia-inducible Factor 1 Related Peptide;缺氧诱导因子1相关肽的活性及机制研究
15.Research of the Screen and Activity of Relative Peptide of Hypoxia-Inducible Factor-1;缺氧诱导因子1相关肽的筛选及活性研究
16.Expression and Significance of HIF-1α in Human Astrocytoma;人星形细胞瘤中缺氧诱导因子-1α的表达及意义
17.Expression and Clinical Significance of HIF-1α Receptor in Human Hepatocellular Carcinoma;肝细胞癌中缺氧诱导因子-1α的表达及临床意义
18.Expression of HIF1-α on Myocardium and Lung in Rats Model of Asphyxia Death;鼠窒息后缺氧诱导因子1-α在心、肺中的表达
相关短句/例句
HIF-1α缺氧诱导因子
1.The dynamic changes of HIF-1α in intracerebral hemorrhage rats and the influence of rhEPO on it脑出血大鼠脑组织缺氧诱导因子的动态变化及促红细胞生成素对其的影响
2.The experimental study of the effects about rhEPO on brain edema and HIF-1α in rats with intracerebral hemorrhage促红细胞生成素对脑出血大鼠脑水肿和缺氧诱导因子的影响
3.AIM:To investigate the effect of hypoxia-inducible transcription factor-1α(HIF-1α)on proliferation of and the VEGF expression in SW480 cells,so as to explore the possible mechanism of HIF-1α regulation on cell proliferation.目的:研究转录因子-缺氧诱导因子-1α(HIF-1α)在缺氧条件下对人结肠癌SW480细胞增殖的作用,以及HIF-1α对血管内皮生长因子(VEGF)表达的影响,研究HIF-1α调节SW480细胞增殖的机制。
3)hypoxia inducible factor-1α缺氧诱导因子
1.Objective To investigate the role of hypoxia inducible factor-1α (HIF-1α) in the hy- poxic protection effects of Acanthopannx Senticosus Saponins (ASS) on neural cells and the potential regulatory mechanism.目的探讨缺氧诱导因子(HIF)-1α在刺五加皂苷(ASS)对神经元缺氧保护中的作用及可能的调控机制。
4)Hypoxia-inducible factor-1α缺氧诱导因子-1α
1.Expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in the retina of diabetic rats;糖尿病大鼠视网膜中缺氧诱导因子-1α和血管内皮生长因子表达的研究
2.Effects of Chinese herbs for replenishing qi and resolving stagnation on hypoxia-inducible factor-1α and vascular endothelial growth factor in granulation tissue of skin ulcers in rats with diabetes;益气化瘀中药对糖尿病皮肤溃疡大鼠缺氧诱导因子-1α和血管内皮细胞生长因子的影响
3.Expression of hypoxia-inducible factor-1α in endometriosis;缺氧诱导因子-1α在子宫内膜异位症的表达及意义
5)hypoxia-inducible factor-1 alpha缺氧诱导因子-1α
1.Expression of Hypoxia-inducible Factor-1 Alpha in Gastric Adenocarcinoma and Its Relationship with Cell Proliferation and Angiogenesis;胃腺癌组织中缺氧诱导因子-1α的表达及其与细胞增殖和血管形成的关系
2.The overexpression and clinical significance of hypoxia-inducible factor-1 alpha and carbonic anhydrase Ⅸ in renal cell carcinoma;目的探讨缺氧诱导因子-1α(HIF-1α)与碳酸酐酶9(CAⅨ)在肾细胞癌中的表达及相互关系。
6)HIF-1α缺氧诱导因子1α
1.Objective To investigate the effect of trichostatin A(TSA) on the expression of HIF-1α and VEGF in lung adenocarcinoma cell line A549 under hypoxic condition.目的探讨组蛋白去乙酰化酶1抑制剂曲古抑菌素A(trichostain A,TSA)对低氧条件下人肺腺癌细胞株A549缺氧诱导因子1α(hypoxia induced factor 1α,HIF-1α)和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。
2.HIF-1α,a crucial transcriptional control gene in signaling cell to adapt to anaerobic microenvironment,can activate the expression of many anaerobic-responding genes which includes the expression of Glut1 gene,in order to supply energy for tumor under hypoxia.缺氧诱导因子1α(HIF-1α)是介导细胞对缺氧微环境进行适应性反应的关键性转录调控基因,能激活许多缺氧反应性基因的表达,其中包括促进肿瘤细胞Glut基因的表达,以满足在乏氧状态下,肿瘤生长的能量需求。
3.Hypoxia-inducible factor-1α(HIF-1α) is a nuclear transcription factor which play activity in a state of hypoxia.缺氧诱导因子1α(HIF-1α)是一个在缺氧状态下发挥活性的核转录因子,在胰腺癌组织及细胞中高表达,促进胰腺癌生长和血管生成,缺氧状态下,间质细胞和胰腺癌细胞之间的相互作用增加。
延伸阅读
正常人白细胞转移因子 , 白细胞转移因子,转移因子药物名称:转移因子英文名:Transfer Factor别名: 正常人白细胞转移因子 , 白细胞转移因子,转移因子外文名:Transfer Factor ,TF适应症: 为细胞免疫反应增强剂,能将细胞免疫活性转移给受体,以提高受体的免疫功能。临床上用于治疗某些抗生素难以控制的病毒性或酶菌性细胞内感染(如带状皰疹、流行性乙型脑炎、白色念珠菌感染等)。对恶性肿瘤可作为辅助治疗剂,对自体免疫性疾病也有一定治疗作用。 用量用法: 一般采用皮下注射,注于上臂内侧或大腿内侧腹股沟下端,1次注射1支,每周1~2次,1个月后改为每2周1次。对带状疱疹,一般只需注射1次。 规格: 注射液:每支2ml,相当于1×1000000000白细胞提取物(上海产),北京产则相当于5~10×1000000000. 注:严禁静脉给药.类别:免疫调节剂
