1)humanized monoclonal antibody人源化单克隆抗体
1.A method for evaluation of in vitro and in vivo anti-tumor activity of anti-Her2 humanized monoclonal antibody;抗HER2人源化单克隆抗体体内外抗肿瘤活性评价方法的建立
2.The mechanism,clinical uses and adverse reactions of immunosuppressive drugs which have been used or studied in clinic were reviewed,including mycophenolate mofetil,tacrolimus,sirolimus,mizoribine,humanized monoclonal antibody,FTY720 etc.综述了已在临床使用或处于临床研究的霉酚酸酯、他克莫司、西罗莫司、咪唑立宾、人源化单克隆抗体、FTY72 0等新免疫抑制剂的作用机制、临床用途及不良反应等情况 ,给临床合理用药提供帮助。
英文短句/例句
1.Preparation of the humanized anti-human thyroglobulin monoclonal antibodies抗人甲状腺球蛋白人源化单克隆抗体的制备
2.Preparation of McAb Against γ Chain of Human IgG and Application in the Quantitative Detection of VEGF Huaman Monoclonal Antibodies;抗人IgGγ链单克隆抗体的研究及其在VEGF人源化单克隆抗体检测中的应用
3.THE INFLUENCE OF MOLECULAR TARGETED THERAPY OF CANCERBASED ON THE HUMANIZED MONOCLONAL ANTIBODY人源化单克隆抗体用于肿瘤分子靶向治疗的研究进展
4.Expression and Analysis of Humanized Anti-HER2 Monoclonal Antibody in Kluyveromyces lactis抗HER2人源化单克隆抗体在乳酸克鲁维酵母中的高效表达及其产物分析
5.Non-clinical Pharmacokinetic and Pharmacodynamic Study of Humanized Anti-CD20 Monoclonal Antibody;重组抗CD20人源化单克隆抗体的非临床药代动力学与药效动力学研究
6.The Initial Research of the Preparation of Humanized Mouse Anti-human cTnI Antibody;鼠源性抗人心肌肌钙蛋白I单克隆抗体人源化改造的初步研究
7.Humanization and Molecular Downsizing of mAb3D3 against Human Lung Cancer;抗人肺癌单克隆抗体3D3的人源化及分子小型化研究
8.Humanization of Mab SM5-1 and the Anti-tumor Effects in Vitro and Vivo;SM5-1单克隆抗体的人源化及其体内外抗肿瘤作用研究
9.Humanization of Monoclonal Antibody Against Chikungunya Virus and Study on the Mammalian Cell High Productive Expression;抗基孔肯亚病毒单克隆抗体人源化及真核细胞高效表达研究
10.Pharmacokinetics of Recombinant Human Rabies Monoclonal Antibody;重组人源化抗狂犬病毒单克隆抗体的药代动力学研究
11.Indirect ELISA Determination of Recombinant Human Anti-EGFR Monoclonal Antibody in Rhesus Serum间接ELISA法测定猕猴血清中重组人源化抗EGFR单克隆抗体的含量
12.Expression and purification of the extracellular factor from Streptococcus suis type 2 of human origin strain ZYH24 and preparation of its monoclonal antibodiesSS2人源分离株ZYH24 EF的表达纯化及其单克隆抗体的制备
13.Preparing Human TNF-α Monoclonal Antibody to Treat Allergic Rhinitis制备人源性TNF-α单克隆抗体治疗变应性鼻炎
14.The Preparation of Anti-human MUC1 Monoclonal Antibodies and Expression of Glycosylated MUC1;人MUC1单克隆抗体的制备及基化MUC1抗原的表达
15.Expression and Purification of Recombinant Anti-human CD25 Chimeric Monoclonal Antibody重组抗人CD25嵌合单克隆抗体的表达及纯化
16.The Application of the Rat Anti-human RANTES mAb in Reducing the Rejection in Rat Small Bowel Transplant and the Humanization of the mAb;大鼠抗人RANTES单克隆抗体在减轻大鼠小肠移植排斥反应中的应用及其人源化
17.Therapeutic mAbs has developed from reshaping antibody and humanized antibody to fully human antibody in order to lower supersensitivity resulting from mouse antibody.为了降低鼠源抗体引起的超敏反应,治疗性单克隆抗体已由改型抗体,人源化抗体发展到全人抗体。
18.Purification of Human Mutant CD59 Protein and Preparation of Monoclonal Antibody;人突变CD59蛋白的提取纯化与单克隆抗体的制备
相关短句/例句
humanized recombined CD25 monoclonal antibody人源化抗CD25单克隆抗体
3)humanized anti-HER2 monoclonal antibody抗HER2人源化单克隆抗体
1.Objective: To study whether the humanized anti-HER2 monoclonal antibody could be expressed in Pichia pastoris, and to investigate the structure and the activity of the expressed products.方法:合成抗HER2人源化单克隆抗体的全基因,构建轻重链双表达盒表达载体,转入毕赤酵母中;通过表型筛选和诱导表达实验得到抗体表达工程菌,对表达产物进行分离纯化和活性测定。
4)VEGF huaman monoclonal antibodiesVEGF人源化单克隆抗体
5)human monoclonal antibody人源单克隆抗体
6)human monoclonal anti-D抗-D人源性单克隆抗体
1.More recently, molecular biology techniques have been used to produce human monoclonal anti-D in a variety of differe.各种抗-D人源性单克隆抗体和基因工程抗体已经成为发展方向。
延伸阅读
单克隆抗体单克隆抗体monoclonalantibody单一克隆产生的并针对单一抗原决定簇的均一性抗体。它见于免疫增生性疾病，也可通过杂交瘤技术人工产生。细胞杂交是20世纪60年代建立起来的一种新技术，把种内或种间细胞融合后，可成为新的细胞。这种含有双亲细胞核的细胞经有丝分裂为两个单核子细胞，子细胞核内含有双亲细胞的染色体。1975年分子生物学家G.J.F.克勒和C.米尔斯坦在细胞杂交技术的基础上，创立杂交瘤技术，他们把可在体外培养和大量增殖的小鼠骨髓瘤细胞与经抗原免疫后的纯系小鼠脾细胞融合，成为杂交细胞系，既具有瘤细胞易于在体外无限增殖的特性，又具有抗体形成细胞的合成和分泌特异性抗体的特点。将这种杂交瘤作单个细胞培养，可形成单细胞系，即单克隆。利用培养或小鼠腹腔接种的方法，便能得到大量的、高滴度的、非常均一的抗体，其结构、氨基酸顺序、特异性等都是一致的，而且在培养过程中，只要没有变异，不同时间所分泌的抗体都能保持同样的结构与机能。这种单克隆抗体是用其他方法所不能得到的。这项新技术从根本上解决了在抗体制备中长期存在的特异性和可重复性问题。单克隆抗体可直接用于人类疾病的诊断、预防、治疗以及免疫机制的研究，为人类恶性肿瘤的免疫诊断与免疫治疗开辟了广阔前景。
