单纯疱疹病毒胸苷激酶,Herpes simplex virus thymidine kinase
1)Herpes simplex virus thymidine kinase单纯疱疹病毒胸苷激酶
1.Aim To observe in vitro cytotoxicities of GCV and CTL to rat mammary cancer cells transfected with herpes simplex virus thymidine kinase(HSV TK) and costimulatory molecule(B7) genes via retrovirus vector.目的 观察羟甲基无环鸟苷 (GCV)、CTL对逆转录病毒介导的转染单纯疱疹病毒胸苷激酶 (HSV TK)和共刺激分子 (B7)双基因的大鼠乳腺癌细胞的体外杀伤作用。
2.Objective: To investigate the role of herpes simplex virus thymidine kinase (HSV-tk) gene expression driven by vascular endothelial growth factor (VEGF) promoter followed by ganciclovir (GCV) administration in killing hepatocellular carcinoma(HCC) cells in vitro.目的 :构建携带受血管内皮生长因子 (VEGF)启动子调控的单纯疱疹病毒胸苷激酶基因 (HSV- tk)的重组腺病毒载体 ,并探讨该重组腺病毒对体外培养的肝癌细胞的特异性杀伤活性。
3.Under the current circumstance of cancer gene therapy, herpes simplex virus thymidine kinase (HSV-tk) suicide gene therapy is regarded as a promising strategy because it is independent of the genetic background of carcinogenesis, which is not clear yet, and.当前,肿瘤基因治疗所面临的一个主要问题是基因载体的低效率,而单纯疱疹病毒胸苷激酶(HSV-tk)基因治疗中存在的旁观者效应则至少在一定程度上使该问题得以解决。
英文短句/例句

1.Construction of Enhanced Green Fluorescent Protein and HSV1TK Co-expression Vector and Expression in Ovarian Cancer Cells SKOV3Ⅰ型单纯疱疹病毒胸苷激酶真核表达载体的构建及其表达鉴定
2.Effects of adenovirus-mediated HSV-tk/GCV system on lens epithelium腺病毒载体介导的单纯疱疹病毒胸苷激酶基因/丙氧鸟苷体系对晶状体上皮细胞的作用
3.Construction of eukaryotic expression vector containing thymidine kinase gene and its expression in esophageal cell line Eca-109单纯疱疹病毒胸苷激酶基因真核表达载体的构建及其在食管癌细胞中的表达
4.Construction of Eukaryotic Co-expression Vector Containing Herpes Simplex Virus Thymidine Kinase and Green Fluorescent Protein单纯疱疹病毒胸苷激酶与绿色荧光蛋白基因真核共表达质粒的构建
5.An Experimental Study on the Gene Therapy for Human Gastric Carcinoma Using Wild-type P53 Gene and Herpes Simplex Virus Thymidine Kinase Gene;外源性人野生型P53基因和单纯疱疹病毒的脱氧胸苷激酶基因治疗胃癌的实验研究
6.Detection of Herpes Simplex virus DNA and Varicella Zoster virus DNA in aqueous humor of patients with corneal endothelitis by polymerase chain reaction聚合酶链反应检测角膜内皮炎房水中单纯疱疹病毒Ⅰ型DNA及带状疱疹病毒DNA
7.An Experimental Study of the Inhapition of HSV by Cyclocytidine and Heparin环胞苷,肝素对单纯疱疹病毒抑制作用的实验研究
8.Effect of acyclovir combined with polyinosinic-polycytidylic acid injection on herpes simplex keratitis无环鸟苷联合聚肌胞治疗单纯疱疹病毒性角膜炎临床观察
9.Detection of HSV antigen in clinical specimens by McAb-ELISA用单克隆抗体酶联免疫法检测临床标本中单纯疱疹病毒抗原
10.CT Diagnosis of Herpes Simplex Encephalitis in Children小儿单纯疱疹病毒性脑炎的CT诊断
11.Construction of A New Type Herpes Simplex Virus Ⅱ DNA Vaccine单纯疱疹病毒Ⅱ型新型DNA疫苗的构建
12.Experimental Study of the Facial Nerve Paralysis Induced by Reactivation of Latent Herpes Simplex Type-1 Infection in Mice;Ⅰ型单纯疱疹病毒潜伏感染再激活致小鼠面瘫的实验性研究
13.Delayed Dexamethasone Treatment in Combination with Acyclovir Protect Experimental Herpes Simplex Encephalitis in Mice糖皮质激素治疗对单纯疱疹病毒性脑炎预后的影响
14.Any of several viral diseases causing the eruption of small blisterlike vesicles on the skin or mucous membranes, especially herpes simplex or herpes zoster.疱疹几种病毒性疾病之一,引起皮肤表层水泡状小泡或粘膜发疹,尤指单纯性疱疹或带状疱疹
15.Construction and identification of recombinant baculovirus vectors of genes encoding helicase-primase of HSV-1单纯疱疹病毒1型解螺旋酶-引物酶编码基因重组杆状病毒载体的构建与鉴定
16.The Experimental Study on Herpes Simplex Encephalitis Induced by Stress;单纯疱疹病毒性脑炎条件致病的实验研究
17.Herpes Simplex Virus( HSV) encephalitis has its own neuroanatomy.单纯疱疹病毒脑炎有特有的神经解剖学特征。
18.Herpes simplex virus Ⅱ DNA was detected in FQ-PCR in genital荧光定量PCR检测生殖器单纯疱疹病毒Ⅱ型DNA
相关短句/例句

hsv-tk单纯疱疹病毒胸苷激酶
1.Aim:To construct a recombinant eukaryotic expression vector containing α-fetoprotein(AFP) promoter-mediated HSV-TK suicide gene,and analyze its specific expression on AFP-positive hepatoma cells.目的:构建甲胎蛋白(AFP)启动子介导的单纯疱疹病毒胸苷激酶(HSV-TK)重组真核表达载体,并检测其在AFP阳性肝癌细胞株的特异性表达。
2.To improve the effectiveness of radiotherapy and chemotherapy to these tumours, a eukaryotic expression vector expressing herpes simplex virus-thymidine kinase (HSV-TK) regulated by hypoxia responsive element (HRE) under hypoxia was constructed.本研究拟构建一种由缺氧反应元件(hypoxia responsive element,HRE)调控的单纯疱疹病毒胸苷激酶(herpes simplex virus-thymidine kinase,HSV-TK)基因的真核表达载体,观察HRE能否增强HSV-TK/丙氧鸟苷(gancyclovir,GCV)系统对乏氧环境中的人Ewing肉瘤细胞系(SK-ES-1细胞)的杀伤作用,为弥补放、化疗的不足探索有效的治疗方法。
3)HSV-tk gene单纯疱疹病毒胸苷激酶
1.Methods:By using Adeasy system, recombinant adenoviral plasmid containing KDR promoter-controlled HSV-tk gene (AdKDR-HSV-tk) was constructed.HUVEC+HUVEC/tk混合细胞的存活率,随HUVEC/tk细胞比例的增加而降低,说明腺病毒介导的KDR启动子-单纯疱疹病毒胸苷激酶/丙氧鸟苷系统不但能杀伤tk+细胞,也能杀伤未导入tk的细胞,存在明显的旁观者效应。
2.Methods: HSV-TK gene was transfected into PC-3m cells through retrovirus vector, reverse transcription-polymerase chain reaction(RT-PCR) was used to demonstrate the successful transfection and the transcription of HSV-TK gene.目的:探讨单纯疱疹病毒胸苷激酶(herpessimplexvirus-thymidinekinase,HSV-TK)自杀基因体系联合重组干扰素α-2a(rIFNα-2a)对前列腺癌PC-3m细胞的体外杀伤作用。
4)HSV-TK/GCV单纯疱疹病毒胸苷激酶/丙氧鸟苷
1.The application of HSV-TK/GCV gene therapy on bladder cancer;单纯疱疹病毒胸苷激酶/丙氧鸟苷系统对膀胱癌体内杀伤作用的研究
5)Herpes Simplex virus thymidine kinase/ganciclovir单纯疱疹病毒胸苷激酶/羟基无环鸟苷
6)HSV1-sr39TK单纯疱疹病毒Ⅰ型胸苷激酶
延伸阅读

2型单纯疱疹病毒2型单纯疱疹病毒 单纯疱疹病毒2型主要感染生殖道。HSV2是最早被认为在宫颈癌病因中起重要作用的一种病毒。有学者发现宫颈癌患者中HSV2抗体阳性率高达80%以上,而对照组仅为14.14%~57.14%,其抗原阳性率也远较正常对照组及慢性宫颈炎者为高。应用核酸原位杂交及HSV2DNA探针检测,亦发现宫颈癌组织中HSV2DNA相关序列远较正常组织为高,从宫颈癌患者宫颈刮取物中分离出HSV2病毒颗粒,并将分离的病毒株进行细胞转化及小鼠诱发宫颈癌的研究,均获阳性结果,且HSV2与宫颈浸润癌的相关性较宫颈上皮内瘤变(CIN)为强。