1)γ-secretase inhibitorsγ-分泌酶抑制剂
1.Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect;兼有神经保护作用的γ-分泌酶抑制剂的计算机辅助设计、合成及初步活性实验研究
2.Methods A series of compounds were designed,synthesized,and evaluated based on pharmacophore model of γ-secretase inhibitors by virtual screening in MDL.目的通过在数据库中虚拟筛选,以期发现新的γ-分泌酶抑制剂。
英文短句/例句
1.γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cellsγ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖
2.Design and Synthesis of New γ-Secretase Inhibitors新型γ-分泌酶抑制剂的设计与合成
3.Inhibitor and regulator of presenilin for Alzheimer’s disease治疗阿尔茨海默病的早老素/γ-分泌酶抑制剂和调节剂
4.The Effect of γ-secretase Inhibitor-DAPT on Differentiation and Proliferation of Neural Stem Cells in Rats;γ-分泌酶抑制剂DAPT对神经干细胞增殖分化影响及可能机制
5.Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect;兼有神经保护作用的γ-分泌酶抑制剂的计算机辅助设计、合成及初步活性实验研究
6.Study on the Inhibitors of GABA Shunt Enzymes;γ-氨基丁酸（GABA）代谢酶抑制剂的研究
7.Effect of PPI on anaylase release from isolated pancreatic acini.质子泵抑制剂对离体胰腺腺泡淀粉酶分泌的影响
8.Discovery and SAR studies of β-Secretase (BACE) inhibitors from Aloe vera L.库拉索芦荟中β-分泌酶抑制剂的发现和初步构效关系研究
9.Effects of PDE5 Inhibiter Sildenafilon on Airway Mucus Hypersecretion;磷酸二酯酶5抑制剂西地那非对气道粘液高分泌的影响
10.THE PROTECTIVE EFFECTS OF β-SECRETASE INHIBITOR ON INJURY OF PC12 CELLS INDUCED OF OAβ分泌酶抑制剂对岗田酸(OA)诱发PC12细胞损伤的保护作用
11.Small Molecular β-secretase Inhibitor Discovery and Glucokinase Activator Evaluation Correlating with Related Mechanisms Analysis;β-分泌酶小分子抑制剂发现及葡萄糖激酶激动剂筛选和相应作用机理探讨
12.Small doses depress salivary and bronchial secretion and sweating.小剂量可抑制唾液分泌、支气管分泌及出汗。
13.Preparation and Characterization of Monoclonal Antibodies Against Human Secretory Leukocyte Protease Inhibitor and Interleukin 28A;抗人分泌性白细胞蛋白酶抑制剂和白介素-28A单克隆抗体的制备与鉴定
14.Recurrence of prolactin-prod ucing endome-trial stromalsarcoma with sex-cord stromal component treated with progestin an d aro-matase inhibitor用孕激素和芳香酶抑制剂治疗分泌催乳素的伴有性索基质成分的复发性子宫内膜基质肉瘤
15.Dose-Response Relationship of a Novel Phospholipase A_2 Inhibitor in Rat with Acute Hemorrhage Necrotizing Pancreatitis新型分泌型磷脂酶A_2抑制剂对急性出血坏死性胰腺炎大鼠模型的量效关系
16.Protease inhibitory activities of nasal secretion on house dust mite allergen鼻分泌物中蛋白抑制酶与螨变应原蛋白酶间的相互作用
17.Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;γ-分泌酶组分基因APH-1A和PEN-2的转录调控
18.Regulatory effects of gamma-secretase in neural stem cell differentiationγ-分泌酶在神经干细胞分化过程中的调节作用
相关短句/例句
γ-secretase inhibitorγ分泌酶抑制剂
1.SectionⅠ: The expression and activation of Notch signaling in human breast cancer and the effect ofγ-secretase inhibitor on the proliferation of breast cancerBackground:Notch signaling is a pathway highly conserved through evolution which regulates various physiological processes,including stem cell maintenance, differentiation,proliferation and apoptosis.第一部分乳腺癌标本及乳腺细胞系中Notch信号通路的表达、活化及γ分泌酶抑制剂对乳腺癌细胞增殖的影响研究背景:Notch信号传导通路是在进化过程中高度保守的信号传导系统,由Notch受体和配体组成。
3)DAPTγ-分泌酶抑制剂DAPT
1.γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cellsγ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖
4)gamma-secretase inhibitorγ泌肽酶抑制剂
1.Objective To explore the inhitition effect of gamma-secretase inhibitor on Notch signaling molecules in alveolar epithelial type Ⅱ cell(AEC Ⅱ) in a heterocellular culture of AECⅡ and lung fibroblast(LF).目的探讨γ泌肽酶抑制剂在肺泡Ⅱ型上皮细胞(AECⅡ)与肺成纤维细胞(LF)共培养胎鼠模型中对Notch信号分子表达的影响。
5)secretase inhibitor分泌酶抑制剂
1.00 μg·mL~(-1)),β-secretase inhibitor(S4562,100.mL-1)、β分泌酶抑制剂(S4562,100。
6)BACE1 inhibitorβ-分泌酶抑制剂
延伸阅读
酶抑制剂分子式：CAS号：性质：作用于或影响酶的活性中心或必需基团导致酶活性下降或丧失而降低酶促反应速率的物质，可分为可逆抑制剂和不可逆抑制剂。对酶有一定的选择性，只能对某一类或几类酶起抑制作用。一价阴离子（X—、NCO—、NCS—、CN—、CH3COO—等），磺胺，草酸盐，苯胺，咪唑，喹啉羧酸，吡啶羧酸盐等都是天然碳酸酐酶抑制剂。抑制剂进入酶活性部位并且改变金属离子的配位层。利用抑制剂作为酶的修饰剂，可获得有关活性部位结构及反应机理等信息。
