1)PML-RARα fusion proteinPML-RARα融合蛋白
1.5 μmol/L As2O3 was incubated for 24 hours and 48 hours,then total protein was extracted,expressions of subunit β1 and PML-RARα fusion protein were determined by Western blot.5μmol/LAs2O3干预NB4细胞,分别提取干预24小时及48小时后的总蛋白;以Western blot检测蛋白酶体β1亚基及PML-RARα融合蛋白表达变化,并进行灰度分析。
英文短句/例句
1.The Study on Molecmle Mechanism of NE Cleaved PML-RARα in APL PathogenesisNE介导的PML-RARα融合蛋白裂解产物在APL发生中的分子机制研究
2.Detection of PML/RARα Fusion Gene in Acute Promyelocyte Leukemia急性早幼粒细胞白血病PML/RARα融合基因的检测
3.Detection of PML/RARα Fusion Gene Transcripts in Patients with APL Using Real-time Quantitative PCR实时定量PCR检测急性早幼粒细胞白血病患者PML/RARα融合基因转录本
4.Detect PML-RARα fusion gene and analyse its clinical significance in acute promyelocytic leukemia动态监测PML-RARα融合基因对急性早幼粒细胞白血病的临床意义
5.The detection of PML-RARα fusion gene in promyelocytic leukemia to monitor minimal residual diseasePML/RARα融合基因检测早幼粒细胞白血病微小残留病
6.Preparation of DNA Biosensor for Detection of PML-RARα Fusion Gene in Acute Promyelocytic Leukemia检测急性早幼粒细胞白血病PML-RARα融合基因的DNA传感器研制
7.Detection of expression of PML/RARα fusion gene in acute premyeloid leukemia patients with real-time RT-PCR初治APL患者PML/RARα融合基因表达
8.Effect of SEA on the Distribution and Clonal Expansion of TCR Vβ Subfamilies and the Cytotoxicity of T Cells Stimulated by PML-RARα Peptide.;超抗原SEA对PML-RARα融合多肽诱导TCR Vβ亚家族T细胞克隆性的影响
9.The Research of Specific T Cells Immunological Reaction and DNA Vaccine Construction Based on PML-RARα Fusion Gene;基于PML-RARα融合基因的特异性T细胞免疫反应和基因疫苗构建研究
10.The Study on Screening Target Proteins Interacting with NLS-RARα in Vivio Cells;NLS-RARα相互作用蛋白的筛选与验证
11.Detection of PML-RARa Transcripts in Acute Promyelocytic Leukemia by Real-time Quantitative Reverse Transcriptase Polymerase Chain Reaction;实时定量RT-PCR检测急性早幼粒细胞白血病PML-RARa融合基因
12.Screening and Identification of The Proteins Interacting With NLS-RARα ProteinNLS-RARα蛋白相互作用蛋白的筛选与验证(英文)
13.antibody fusion protein抗体融合蛋白(质)
14.Effect of Immune Response Induced by APL Cells and PML-RARα Vaccine in Vitro and in Vivo;APL细胞和PML-RARα疫苗诱导体内外免疫应答的研究
15.Molecular Mechanisms Underlying PML Nuclear Body PlasticityPML蛋白调控细胞核体可塑性的分子机制研究
16.Advance in diagnosis of APL by detection of PML protein and POD structure and its antibodyPML蛋白、POD结构及其抗体在APL诊断的研究进展
17.Identification of the Interactions Between JTV1 and NLS-RARα in vivo and in vitro带核定位信号的RARα与JTV1蛋白相互作用的验证实验
18.Study of Recombinant Human Serum Albumin-Interferon-α 2b Fusion Protein;重组人血清白蛋白—干扰素α 2b融合蛋白的研究
相关短句/例句
RARα fusion proteinRARα融合蛋白
3)PML/RARαfusion genePML/RARα融合基因
1.Methods FISH was used to detect the AML1/ETO fusion gene and/or PML/RARαfusion gene in 10 AML-M_2 cases,19 AML-M_3 cases and 11 AML cases undetermined as AML-M_2 or AML-M_3 by routine morphology,cytochemical staining and immunophenotyping.方法对初发的经骨髓常规形态学、细胞化学染色和免疫分型初步诊断的10例AML-M2、19例AML-M3,11例AML不能确定为M2或者M3的患者,进行FISH技术检测AML1/ETO和/或PML/RARα融合基因,进而协助诊断和指导治疗。
4)PML/RARα fusion genePML/RARα融合基因
1.PML/RARα fusion gene was detected by using reverse-transcription polymerase chain reaction (RT-PCR) technique.为了了解CD117/CD11b在急性早幼粒白血病细胞初诊及治疗后的表达变化,探讨其表达变化对APL诊断和预后的意义,采用CD45/SSC双参数散点图设门方法进行三色或四色流式细胞术细胞表面及浆内分化抗原分析,应用RT-PCR技术检测骨髓中PML/RARα融合基因的mRNA表达。
2.Detection of the PML/RARα fusion gene by RT PCR in acute promyelocytic leukemia (APL) blasts is not only critical to commence promptly the specific therapy with all trans retinoic acid (ATRA) or arsenic trioxide (As 2O 3), but also essential for the definition of PML breakpoint type and subsequent monitoring of minimal residual disease (MRD).在急性早幼粒细胞白血病 (APL)细胞中迅速、准确检出PML/RARα融合基因对于及时应用全反式维甲酸 (ATRA)或亚砷酸 (As2 O3 )提高诱导缓解率、减轻出血导致的早期死亡至关重要 ,但目前临床上采用的嵌套式RT PCR方法繁琐且费时 ,亟待改进以满足临床APL快速、准确诊断的需要。
3.A new kind of sandwich-type DNA electrochemical biosensor is designed to detect PML/RARα fusion gene in acute promyelocytic leukemia.基于急性早幼粒细胞白血病(APL)中PML/RARα融合基因的碱基序列,设计了新型的锁核酸(LNA)修饰寡核苷酸作为捕获探针和信号探针,研究出一种基于"三明治"传感模式的电化学生物传感器对PML/RARα融合相关基因进行检测。
5)PML-RARα fusion genePML-RARα融合基因
1.A DNA electrochemical sensor was prepared by fixing amino group-modified ssDNA probe with particular DNA sequence of PML-RARα fusion gene in acute promyelocytic leukemia(APL) on the surface of a glassy carbon electrode using covalent bond technology.利用共价键合法,将氨基修饰的具有急性早幼粒细胞白血病PML-RARα融合基因特异性的单链DNA探针固定在玻碳电极表面,构成急性早幼粒细胞白血病DNA传感器(急粒DNA传感器)。
6)NLS-RARα proteinNLS-RARα蛋白
延伸阅读
PM分子式:CAS号:性质:由白色链球菌(Streptomyces.alboniger)发酵制得的抗生素。熔点175.5~177.0℃。旋光度-11(乙醇)。在酸性溶液中分解成为6-二甲胺嘌呤,O-甲基-L-酷氨酸及3-氨基-3-去氧核糖。结构与氨基酰tRNA分子中腺苷相连结的氨基酸末端基因相似,因而它可作氨基酰tRNA的类似物,与正在延伸的多肽链结合,而抑制了蛋白质的合成,并以肽基嘌呤霉素的形式从核糖核蛋白体上早期解离出来。主要用作研究蛋白质合成的生物化学工具。
