1)Wnt/beta-catenin pathwayWnt/beta-catenin通路
1.This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA in various subgroups of acute myeloid leukemia(AML)and to analyze their potential relationship,so as to provide theoretical basis for exploring the role of Wnt/beta-catenin pathway in the pathogenesis of AML.结论:在AML患者中存在beta-catenin及cyclin D1的过度表达,且在部分亚型中存在显著相关性;Wnt/beta-catenin通路在AML中被异常激活,很可能是通过该通路下游靶基因cyclin D1的激活,参与白血病细胞的周期紊乱和异常增殖的调节。
2)Wnt/β-catenin pathwayWnt/β-catenin通路
1.[Objective]To investigate the expression of β-catenin and β-catenin/Tcf complex, two key members in the Wnt/β-catenin pathway, in different differentiated nasopharyngeal carcinoma (NPC ), and elucidate the role of Wnt/β-catenin pathway in neoplastic cells differentiation of NPC.【目的】探讨Wnt/β-catenin通路的枢纽分子β-catenin和β-catenin/Tcf复合体在不同分化程度鼻咽癌中的表达,进而阐明Wnt/β-catenin通路对鼻咽癌分化的作用。
英文短句/例句
1.Effects of Caffeic Acid Phenethyl Ester in Wnt/β-Catenin Signaling Pathway on Human NeurogliomaCAPE在神经胶质瘤异常Wnt/β-catenin通路中的作用及机制研究
2.Expression and Clinical Significance of the Member of Wnt/β-catenin Signaling Pathway in Human Gliomas人脑胶质瘤中Wnt/β-catenin通路相关蛋白的表达及及临床意义
3.The Relationship between the Hepatitis B Virus X Protein and β-Catenin;HBX对Wnt/β-catenin信号转导通路的影响研究
4.Wnt/β-catenin Signal Pathway and Malignant Hematological Disease--ReviewWnt/β-catenin信号通路与恶性血液病
5.Research on the Relationship between Wnt/β-catenin Pathway Activation and Human Ovarian CarcinomaWnt/β-catenin信号转导通路与卵巢癌的相关研究
6.The Effect of Octreotide on Colonic Cancer Cell SW480 and Its Wnt/β-Catenin Signal Transduction Pathway in Vitro;奥曲肽对结肠癌细胞SW480及Wnt/β-catenin信号传导通路的影响
7.Effect of Quercetin on Proliferation of Human Colorectal Cancer Cell Line and on Wnt/β-catenin Signaling Pathway;槲皮素对结肠癌细胞抑制作用及对Wnt/β-catenin信号转导通路的影响
8.Primary Research on the Effects of Wnt/β-catenin Signalling on Pig Satellite Cells Proliferation and Differentiation;Wnt/β-catenin信号通路对猪肌卫星细胞增殖分化影响的初步研究
9.Regulation of Wnt/Beta-Catenin Signal Pathway during Porcine Adipose Tissue Development;Wnt/β-catenin信号通路在猪脂肪组织发育过程中的调控作用
10.Wnt/β-Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells;Wnt/β-Catenin信号通路对正常和肿瘤性肝前体细胞活化的调节
11.Experimential Study on the Canonical Wnt/β-catenin Pathway in Intervertebral Disc Degeneration经典Wnt/β-catenin信号通路在椎间盘退变中的作用及机制研究
12.The Role of Wnt/Beta-catenin Signaling Pathway Hypofunction in Diabetic Patients with Impaired Wound HealingWnt/β-catenin信号通路功能低下在糖尿病合并创面难愈中的作用
13.Studying on the Relevance Between Aging Kidney-Yang Deficiency Syndrome and the Wnt/β-catenin Signaling Pathway by cDNA Microarray Assay运用基因芯片技术分析老龄肾阳虚证与Wnt/β-catenin信号通路的相关性
14.Pathogenesis of osteoarthritis and its relationship with the Wnt/β-catenin pathway骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系
15.Identification of Wnt/β-catenin Signal Pathway in Human Prostate Cancer Cell Lines and Its SignificanceWnt/β-catenin信号通路在多种人前列腺癌细胞系中的表达研究及意义
16.Effects of Wnt/β-catenin signals on the callus modelling and the biomechanical properties of the fractured tibia in miceWnt/β-catenin信号通路对小鼠骨痂塑形和生物力学性能的影响
17.Study on the Role and Mechanism of Wnt/β-catenin Signaling Pathway in the Development of Rat Embryo and Tumorigenesis;Wnt/β-catenin信号通路在胚胎发育和肿瘤发生中作用及其机制的初步研究
18.Varp Interacts with LRP6 and Negatively Regulates Wnt/b-catenin Signaling Pathway;Varp与LRP6相互作用抑制性调控Wnt/b-catenin信号通路
相关短句/例句
Wnt/β-catenin pathwayWnt/β-catenin通路
1.[Objective]To investigate the expression of β-catenin and β-catenin/Tcf complex, two key members in the Wnt/β-catenin pathway, in different differentiated nasopharyngeal carcinoma (NPC ), and elucidate the role of Wnt/β-catenin pathway in neoplastic cells differentiation of NPC.【目的】探讨Wnt/β-catenin通路的枢纽分子β-catenin和β-catenin/Tcf复合体在不同分化程度鼻咽癌中的表达,进而阐明Wnt/β-catenin通路对鼻咽癌分化的作用。
3)Wnt/β-catenin signaling pathwayWnt/β-catenin信号通路
1.Expression of β-catenin,Survivin and C-myc involved in Wnt/β-catenin signaling pathway were detected by immunohistochemistry.材料与方法:将SW480细胞经皮下接种Balb/c-nu/nu裸小鼠,构建裸鼠SW480细胞荷瘤动物模型,观察CPP作用后移植瘤体积和重量的变化,HE染色光镜下观察移植瘤组织形态学变化,免疫组织化学方法检测瘤组织内Wnt/β-catenin信号通路中核心成分β-catenin及其下游靶蛋白Survivin和C-myc表达的变化。
4)Wnt/β-catenin signaling pathwayWnt/β-catenin信号转导通路
1.Objective: The inhibition effect of periplocin extracted from cortex periplocae (CPP) on proliferation of human colon carcinoma cell line SW480 in vitro and in vivo was studied, and the regulation effect of CPP on Wnt/β-catenin signaling pathway and its downstream target genes was investigated.目的:观察香加皮杠柳苷(periplocin extracted from cortex periplocae, CPP)对人结肠癌细胞株SW480在体内外增殖的抑制作用,研究其对SW480细胞内Wnt/β-catenin信号转导通路的调控作用和对β-catenin/TCF下游靶基因的影响,以探讨CPP的抗肿瘤作用机制,为CPP作为抗肿瘤药物开发提供理论依据。
5)Wnt pathwayWnt通路
1.Sulindac induces SMMC-7721 cells apoptosis through inhibiting Wnt pathway;Sulindac通过抑制Wnt通路诱导SMMC-7721肝癌细胞凋亡
2.AIM:To investigate Wnt pathway activity in pancreatic cancer cell lines.目的:研究胰腺癌细胞中Wnt通路的活性变化,观察Wnt通路拮抗剂DKK-1的表达及其在胰腺癌中可能的发生机制,探讨DKK-1对Wnt通路活性的调节作用。
3.The expression of Twist mRNA in SMMC7721 was detected respectively when the WNT pathway was activated and not activated by RT-PCR and real time PCR.05mol/L氯化锂加入人肝癌SMMC7721细胞中培养2h激活WNT通路,然后分别培养6、12、24h,分别为A1、A2、A3组;将0。
6)Wnt signaling pathwayWnt通路
1.Effect on expression of Wnt signaling pathway inhibitor Dickkopf-1;Wnt通路抑制因子Dickkopf-1的表达作用
2.Ectogenetic p53 promotes mRNA of Wnt signaling pathway inhibitor Dickkopf-1;外源性p53对Wnt通路抑制因子Dickkopf-1的表达作用
3.Effects of antitumor-drug cisplatin on expression of Wnt signaling pathway inhibitor;化疗药顺铂对Wnt通路抑制因子的表达作用
延伸阅读
β-catenin分子式：CAS号：性质：原癌基因编码的蛋白质，参与钙依黏附蛋白(cadehrin)胞内结构域介导的信号转导的重要分子。正常细胞内它的浓度较低。在由它介导信号转导的结果中都发现APC(adenomatous polyposis coli，是一种肿瘤抑制蛋白质)，是一个β-连蛋白信号转导的负调节剂。显然β-连蛋白在恶性肿瘤病因研究领域中占有相当重要的地位。一旦APC或β连蛋白发生突变，即可发生信号转导减弱，细胞增殖加快与抑制细胞凋亡等作用，这是至今所了解的正常细胞发生恶变的β-连蛋白作用分子机制。
