1)abnormal expression异常表达
1.Abnormal expression of PI3Kp85 in nasopharyngeal carcinoma鼻咽癌组织中PI3Kp85的异常表达
2.Objective To investigate the clinicalpathological significance of abnormal expression of p33ING1 protein in esophageal squamous cell carcinoma.目的探讨p33ING1蛋白在食管鳞状细胞癌中异常表达的临床病理意义。
英文短句/例句
1.Abnormal expression of keratin in pterygial epithelium翼状胬肉上皮细胞异常表达角蛋白
2.Mechanism of Abnormal Expression of ZNF403 Genes in Laryngeal Squamous Cell Carcinoma;喉癌中ZNF403基因异常表达及其机制研究
3.Abnormal Expression of mGluR1 in Hippocampus of Spontaneously Epileptic Rats;mGluR1在自发性癫痫大鼠海马中异常表达
4.Significance of Aberrant Pim-3 Expression in Gastric CarcinomaPim-3在胃癌中异常表达的意义
5.Abnormal Expression of Endothelin Receptor and Diseases内皮素受体的异常表达与疾病的关系
6.Altered expression of E-cadherin/P120ctn complex in spinal chordomaE-cadherin和P120ctn在脊柱脊索瘤中的异常表达
7.Abnormal expression of PI3Kp85 in nasopharyngeal carcinoma鼻咽癌组织中PI3Kp85的异常表达
8.The Effect of SAM on C-myc Abnormal Expression Induced by As_2O_3 in Normal Human Liver CellsSAM对As_2O_3诱导人正常肝细胞c-myc异常表达的影响
9.Study of the Abnormal Expression of Tissue Enzymes and Oncogenes in the Middle Ear Cholesteatoma中耳胆脂瘤组织酶和癌基因异常表达的研究
10.Aberrant Expression and Its Mechanism of SFRP4-the Antagonists of Wnt in Pancreatic Carcinoma;Wnt拮抗剂SFRP4在胰腺癌中的异常表达及其机制
11.Abnormal Expression of Fragile Histidine Triad (FHIT) Gene Protein in Human Coloretal Carcinoma and Their Clinical Significance;结直肠癌中FHIT蛋白的异常表达及其临床意义
12.Significance of Abnormal HLA Molecules Expression in Colorectal Carcinoma;大肠癌组织HLA及相关分子的异常表达及其意义
13.Aberrant TNF-a and TGF-β_1 Expression by Early Spontaneous Aborters;早期自然流产患者TNF-a 和TGF-β_1的异常表达
14.Expression of DNA on Chromosomal Fragile Sites and the Phenotypic Abnormalities染色体脆性位点DNA表达与表型异常
15.p53 overexpression but inactivation in NPC.结论:NPC中p53表达增加而功能异常。
16.The Correlation Study between Smad4 Abnormal Expression and Colorectal Cancer;Smad4表达异常与结直肠癌的相关性研究
17.Normal-cerebral Palsy Twins Differences in Gene Expression Profiling正常-脑瘫双生子基因表达谱差异研究
18.Differential Expression of MicroRNAs in Mouse Liver under Aberrant Energy Metabolic Status异常能量代谢状态下小鼠肝脏microRNA的差异表达
相关短句/例句
Heterologous expression异源表达
1.The heterologous expression and purification of membrane protein from Mycobacterium tuberculosis;结核分枝杆菌膜蛋白的异源表达与纯化研究进展
2.Cloning and heterologous expression of laccaes isozyme B gene from Trametes sp. 420;栓菌420漆酶同工酶B基因克隆及异源表达
3.Cloning,heterologous expression and purification of a 3-ketosteroid-9α-hydroxylase (KSH) from Mycobacterium sp.NwIB-01分枝杆菌Mycobacterium sp.NwIB-01 3-甾酮-9α-羟基化酶基因的克隆、异源表达及分离纯化
3)differential expression差异表达
1.Differential expression of cytokines in severe aplastic anemia;重型再障细胞因子差异表达的研究
2.Study on seasickeness and differential expression of energy metabolism genes;晕船与能量代谢相关基因的差异表达
3.Investigation of the differential expression proteins in uterine arteries of women with type 2 diabetes mellitus;糖尿病妇女子宫动脉蛋白质差异表达的初步分析
4)different expression差异表达
1.The results showed in low nitrogen,the gladins expression were little influenced,but until high nitrogen stress,the gladins appear different expression,prouduce 4 peculiar tables altogether.2%)胁迫下,籽粒醇溶蛋白出现了差异表达,共产生了4条特异蛋白谱带,其中2条在ω区,另2条在γ区,且γ区的蛋白特异带表达比ω区强。
2.Then MS was used toanalysis the proteins of different expression.利用质谱技术对差异表达的蛋白质进行了肽质量指纹(Peptide Mass Fingerprinting PMF)分析。
3.Different expression and analysis of SLP-76 gene in cancer of the digestive tract and adjacent normal mucosa;目的 分析SLP 76基因在食管癌、贲门癌、胃癌、结肠癌及其癌旁组织中的差异表达。
5)expression difference表达差异
1.The expression differences of isozyme SOD,GSH-Px,COX and Ca2+-ATPase in mice liver mitochondria were determined by PAGE.利用聚丙烯酰胺凝胶电泳法分析了大鼠肝脏线粒体SOD、GSH-Px、COX和Ca2+-ATPase同工酶的表达差异。
2.In this paper,with the consideration of the restraint of linear model and the co-action of many SNPs,we perform logistic regression between gene expression difference and IBD value.研究影响基因表达差异的调控机制对研究人类复杂性状的遗传机制具有重要意义。
3.The expression differences of ADAM28 in HDFC were detected by immunocytochemistry,RT-PCR and Western blot assays.方法应用反义核酸技术,设计并合成与ADAM28 mRNA特异序列互补的AS-ODN和正义对照S-ODN转染HDFC后,通过免疫细胞化学、RT-PCR和Western blot检测细胞中ADAM28的表达差异。
6)differential expression表达差异
1.Differential expression of E6, LTP, PRP and Expansin gene families, especially that of ? and LTP gene families, were observed from 10DPA cotton fiber and 10DPA mutant.利用cDNA芯片技术分析E6、Lipid transfer protein (LTP)、Proline-rich protein(PRP)、Expansin、Tubu-lin、Annexin等家族的63个棉花纤维发育相关基因,在陆地棉徐州-142开花后10d纤维组织及其无长绒无短绒突变体开花后10d胚珠中的表达差异,发现属于E6、LTP、PRP、Expansin家族的基因在两种组织中存在显著的表达差异,符合前人的报道。
2.Real-time PCR technique was employed to analyze the differential expression of two aroma related genes,β-glucosidase and β-primeverosidase genes,in different maturity shoots and different source cultivars in spring season of tea plant(Camellia sinensis).采用实时定量PCR技术,分析了‘龙井43’茶品种春季不同嫩度新梢,以及8个不同品种春季一芽二叶的β-葡萄糖苷酶和β-樱草糖苷酶基因的表达差异。
3.Cloning and differential expression of Bombyx mori carboxylesterase gene;moricarboxylesterase,BmCarE)基因全长cDNA,并用实时荧光定量PCR检测了添毒后12h、36h、72h BmCarE在感、抗BmDNV-Z家蚕品系中肠内的表达差异。
延伸阅读
表达谱差异分析表达谱差异分析(differential expression profiling)主要包括基因表达谱(gene expression profiling) 和蛋白质表达谱(protein expression profiling) 。大规模表达谱分析已经成为认识疾病分子机制的有利方法,在癌症研究等方面取得了一定的进展。成功的表达谱分析基于实验及其过程分析的有机结合。实验过程从关注的疾病开始,首先收集大量的疾病相关组织样本,样本数量可从10 多个到数百个,但必须足以对每一组织类型及个体差异进行比较分析,而且许多情况下不能仅简单地分为正常和疾病组织。例如,在对糖尿病的研究中,所收集的样本来自健康人、胰岛素耐受和糖尿病病人的不同试验阶段,如胰岛素治疗前后。样品还应包括其他器官的取材,以便进行基因表达的组织分布研究。为了便于对后来的实验数据进行分析管理,需采集并储存所有的组织样本和临床参数。接下来进行组织样本的处理,利用生物芯片(寡核苷酸芯片、cdna 芯片或全基因组芯片) 进行表达谱测定,并进行生物信息学分析。通常,表达谱的分析结果需进一步的实验加以证实。定量rt2pcr 是最灵敏的确证方法,该方法还可以将确证实验的范围扩大到原测组织以外的更广泛的组织和组织类型,揭示基因表达的组织分布情况。确证实验揭示了疾病相关基因。据此,可以进行进一步研究,探索这些基因的功能,开发新的治疗手段。例如,对于正常和疾病组织中表达有显著性变化的基因,可以进行新治疗靶点的鉴定和确定研究,或利用实验和分析工具研究分析其功能;对于疾病组织中活性升高的酶,可以当作前药活化酶进行鉴定研究。典型的表达谱能够显示疾病过程中有大量的已知基因表达的改变,而许多已知基因的代谢通路、表达产物酶学分类和蛋白质功能业已发表,将两者对照分析,可以鉴定出酶活性,选择其中可能成为前药活化酶的部分进行进一步研究;对于疾病特异的蛋白质,可以进行抗原表型分析,决定疫苗的开发策略。寻找差异表达基因的方法除芯片技术外,一些新的检测方法如差异显示pcr ( differential display pcr, dd－pcr) 、消减杂交( suppression subreactive hy bridization , ssh) 等也相继得到结合应用。
