1)Smad4 geneSmad4基因
1.Objective To study the inhibitory effect of Smad4 gene on the growth of human pancreatic adenocarcinoma cell line(HS766T)cells.目的 探讨Smad4基因在人胰腺癌细胞中的肿瘤抑制作用。
2.Objective : To study the association between Smad4 gene expression levels change,abnormal methylation of CpG islands in colorectal cancer and its clinical and pathological features,and explore the effect of Smad4 protein express on the development and progression in colorectal tumor.目的:研究结直肠组织Smad4 mRNA及其蛋白表达水平变化、Smad4基因CpG岛异常甲基化与结直肠癌及其临床病理特征的关联性。
3.Results:Effect of siRNA of Smad4 gene in PanIN cells was confirmed by RT-PCR and Western blot.基于此目的,在已成功分离建立K-ras突变启动的PanIN细胞株基础上,本研究拟进一步应用RNA干扰技术沉默PanIN细胞株中内源性Smad4表达,以探讨siRNA干扰Smad4基因对PanIN细胞恶性转化作用。
英文短句/例句
1.Expression of Smad4 Gene in Colorectal Cancer and Its SignificanceSmad4基因在大肠癌中的表达及意义
2.Construction and Identification of a Eukaryotic Expression Vector for Small Interfering RNA Targeting Smad4 GeneSmad4基因siRNA表达载体的构建与鉴定
3.Role of Smad4 Gene in Vestibular Development of Inner Ear in Mice;Smad4基因在小鼠内耳前庭发育中作用的初步研究
4.Significance of Expression of TGFβ1, Smad2 and Smad4 in Hepatocellular Carcinoma Tissues;肝细胞癌中TGFβ1及Smad2、Smad4基因表达的初步探讨
5.Expression of TGFβ1 and Smad4 gene in human hepatocellular carcinoma tissues and its significanceTGFβ1与Smad4基因在肝细胞癌中的表达及意义
6.Expression of Smad 4 gene in human hepatocellular carcinoma tissues and its significance肝细胞癌组织Smad4基因表达及其临床意义的研究
7.Targeted Disruption of Smad4 in Mouse Gut Epithelium Results in Gastrointestinal Adenoma;小鼠消化道上皮部分细胞剔除Smad4基因引发胃肠道腺瘤
8.Keratinocyte Specific Smad4 Knockout Lead to Overactivation of Mouse Follicle Stem Cells;角质细胞特异性Smad4基因敲除导致小鼠毛囊干细胞过度活化
9.Effects of Smad4 gene silencing by small interfering RNA on the proliferation of prostate cancer cells in vitroRNAi沉默Smad4基因表达对人前列腺癌细胞增殖的影响
10.Effect of Smad4 silencing on the growth and vascularization of pancreatic cancer transplantation tumor in nude miceSmad4基因沉默促进PanIN裸鼠移植瘤增殖和微血管形成的研究
11.Refinement of High Heterozygosity Loss on Chromosome in Sporadic Colorectal Cancer;散发性结直肠癌高频杂合缺失精细定位及SMAD4基因突变的初步研究
12.The Expression and Significance of Gene p53、p16 and Smad4 Receptors in Pancreatic Carcinomas;抑癌基因p16、p53和Smad4在胰腺癌中的表达及临床意义
13.Expression and Clinical Significance of SEL1LmRNA and Protein, Smad4 Protein in Esophageal Cancer;SEL1L基因及其蛋白、Smad4蛋白在食管癌中的表达及其临床意义
14.The expression and clinical significance of DcR3 and Smad4 in gastric cancer胃癌组织中诱捕受体3和抑癌基因Smad4的表达及其临床意义
15.Study on Chondrocyte Specific Smad4 Gene Conditional Knockout Resulting in Hearing Loss and Inner Ear Malformation in Mice;软骨细胞特异性Smad4条件基因敲除导致小鼠听力丧失和内耳发育畸形的相关研究
16.Expression of Transforming Growth Factor β Receptor Ⅰ、Ⅱ and SMAD4 and Their Clinical Significance in Gastric Cancer;转化生长因子β受体Ⅰ、Ⅱ和SMAD4在胃癌中的表达及其临床意义
17.Expression of Smad4 and TGF-β1、TGF-β RⅡ in Cholangiocarcinoma Tissues and Its Biological Significance;胆管癌组织Smad4和转化生长因子β1及Ⅱ型受体的表达及意义
18.Expression and significance of Smad4 and TGF-β receptor Ⅱ in cervical adenocarcinomaSmad4和转化生长因子β受体Ⅱ在宫颈腺癌中的表达及意义
相关短句/例句
Smad 4 geneSmad4基因
1.The antisense Smad 4 gene could down-regulate the expression of Smad 4 in.方法 采用逆转录病毒将反义Smad4基因导入四氯化碳 (CCl4) /乙醇诱导的小鼠肝脏 ,经Southern印迹证实反义Smad4基因已经整合入小鼠肝脏 ,Northern印迹及Western印迹方法显示反义Smad4基因能下调Smad4的表达。
3)Smad4Smad4基因
1.Co-mediator Smads (Smad4) functions in TGF-β signaling pathways.为了研究Smad4基因在内耳发育中的作用，利用Cre-LoxP系统形成软骨细胞特异性Smad4条件基因敲除小鼠，绕过了应用完全基因敲除Smad4基因后导致小鼠在胚胎发育早期(e6。
4)DPC4/Smad4 geneDPC4/Smad4基因
5)Smad_4抑癌基因Smad4
1.objective To study the expression of TGF-β_1 and Smad_4 in human hepatocellular carcinom(HCC) and their biological significances.目的探讨转化生长因子-β1(TGF-β1)与抑癌基因Smad4(TGF-β1)在肝癌组织中的表达意义。
6)Smad 4Smad4
1.The Expression of Transforming Growth Factor Beta 1 and Smad 4 in Colorectal Cancer;TGF-β1及Smad4在大肠癌组织中的表达及临床意义
2.Objective:To construct and identify the small hairpin RNA(shRNA) expression vector for Smad 4/DPC 4 gene.目的:构建Smad4基因小发夹RNA(shRNA)表达载体。
3.Objective To investigate the abnormal change of Smad 4,Smad 6 and Smad 7 in pancreatic cancer and their relationship.目的研究Smad4、Smad6和Smad7在胰腺癌组织中的改变及其相互关系。
延伸阅读
J基因分子式：CAS号：性质：为免疫球蛋白V区与C区之间的连接区(J区)编码的基因。
