Hangtaimycin生物合成基因簇及其应用的制作方法

文档序号：22082846发布日期：2020-09-01 19:40阅读：196来源：国知局
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Hangtaimycin生物合成基因簇及其应用的制作方法

本发明属于微生物基因工程领域，具体涉及一种hangtaimycin生物合成基因簇及其应用。



背景技术：

hangtaimycin是一个具有独特δ不饱和六元环内酯以及末端环二肽单元的新颖聚酮聚肽类杂合化合物(图1)。虽然hangtaimycin最初于2016年从链霉菌streptomycesspectabiliscpcc200148中分离获得，却只进行了初步的抗肿瘤及抗白色念珠菌的活性测试。我们在对链霉菌streptomycesspectabiliscctccm2017417的活性次生代谢产物研究中分离鉴定出hangtaimycin，并对hangtaimycin及其衍生物进行了更广泛的生物活性考察和生物合成机制研究。

生物学活性测试结果显示，hangtaimycin的甲醇水解产物hangtaimycina具有优于一线临床保肝药品水飞蓟宾的降谷丙转氨酶和谷草转氨酶的活性，同时还表现出比抗炎药物雷帕霉素更显著的抗炎活性，具有开发成新一代保肝护肝药品的重要前景。hangtaimycin及其醇解产物hangtaimycina的生物合成基因簇和生物合成机制迄今国内外尚未见报道。



技术实现要素：

针对现有技术的不足，本发明的目的是提供一种hangtaimycin生物合成基因簇及其应用。

为实现上述目的，本发明的技术方案如下：

第一方面，本发明的第一个目的是提供hangtiamycin生物合成基因簇(图2)。

本发明在链霉菌streptomycesspectabiliscctccm2017417基因组测序和生物信息学分析的基础上，发现可能负责hangtaimycin生物合成的基因簇，通过基因簇敲除及发酵产物检测(图3-13)，证明了链霉菌streptomycesspectabiliscctccm2017417基因组中负责曲张链丝菌素生物合成的基因簇。一种hangtaimycin生物合成基因簇，其特征在于：该生物合成基因簇的核苷酸序列如seqidno.1的第1-91594位的碱基序列所示，包含21个基因，具体为：

(1)负责hangtaimycin碳骨架合成及修饰的18个基因：

1)1号基因：htma1位于基因簇核苷酸序列第10986-25451个碱基处，长度为14466个碱基对，编码聚酮合酶，4821个氨基酸；

2)2号基因：htma2位于基因簇核苷酸序列第25448-47611个碱基处，长度为22164个碱基对，编码杂合的聚酮合酶与非核糖体肽合成酶，7387个氨基酸；

3)3号基因：htma3位于基因簇核苷酸序列第47611-61857个碱基处，长度为14247个碱基对，编码聚酮合酶，4748个氨基酸；

4)4号基因：htma4位于基因簇核苷酸序列第1-822个碱基处，长度为822个碱基对，编码游离的酮基还原酶，273个氨基酸；

5)5号基因：htma5位于基因簇核苷酸序列第9823-10578个碱基处，长度为756个碱基对，编码ii型硫酯酶，251个氨基酸；

6)6号基因：htma6位于基因簇核苷酸序列第79115-80338个碱基处，长度为1221个碱基对，编码游离的失活酮基合成酶，负责脱羧，407个氨基酸；

7)7号基因：htma7位于基因簇核苷酸序列第83995-85938个碱基处，长度为1944个碱基对，编码游离的酰基转移酶，负责延伸单元的转移，647个氨基酸；

8)8号基因：htma8位于基因簇核苷酸序列第78787-79113个碱基处，长度为327个碱基对，编码游离的酰基载体蛋白，108个氨基酸；

9)9号基因：htmb1位于基因簇核苷酸序列第61854-69500个碱基处，长度为7647个碱基对，编码非核糖体肽合成酶，2548个氨基酸；

10)10号基因：htmb2位于基因簇核苷酸序列第69515-78790个碱基处，长度为9276个碱基对，编码非核糖体肽合成酶，3091个氨基酸。

11)11号基因：htmb3位于基因簇核苷酸序列第2214-3872个碱基处，长度为1659个碱基对，编码游离的氨酰转移酶，552个氨基酸；

12)12号基因：htmh位于基因簇核苷酸序列第81630-83990个碱基处，长度为2361个碱基对，编码脱水酶，786个氨基酸；

13)13号基因：htmi1位于基因簇核苷酸序列第934-2217个碱基处，长度为1284个碱基对，编码异构化酶，427个氨基酸；

14)14号基因：htmi2位于基因簇核苷酸序列第3932-4564个碱基处，长度为633个碱基对，编码异构化酶，210个氨基酸；

15)15号基因：htmo位于基因簇核苷酸序列第8335-9717个碱基处，长度为1383个碱基对，编码氨基合酶，460个氨基酸；

16)16号基因：htmp位于基因簇核苷酸序列第86021-87256个碱基处，长度为1236个碱基对，编码细胞色素p450氧化酶，411个氨基酸；

17)17号基因：htms位于基因簇核苷酸序列第80359-81642个碱基处，长度为1284个碱基对，编码羟甲基戊二酸单酰辅酶a合成酶，427个氨基酸；

18)18号基因：htmt位于基因簇核苷酸序列第6346-7692个碱基处，长度为1257个碱基对，编码糖基转移酶，418个氨基酸；

(2)负责调控和转运的3个基因：

19)19号基因：htmr1位于基因簇核苷酸序列第7768-8274个碱基处，长度为507个碱基对，编码转录调控因子，168个氨基酸；

20)20号基因：htmr2位于基因簇核苷酸序列第88943-89740个碱基处，长度为798个碱基对，编码lysr家族转录调控因子，265个氨基酸；

21)21号基因：htmk位于基因簇核苷酸序列第89765-91594个碱基处，长度为1830个碱基对，编码ser/thr蛋白激酶，609个氨基酸。

第二方面，本发明提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸序列可利用聚合酶链式反应pcr的方法或包含所述seqidno.1所示序列的第1-91594位的dna作为探针，以southern杂交方法从其它生物体中得到与hangtaimycin生物合基因簇相似的基因。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸序列通过包括体内或体外插入、缺失、置换、突变、与其它来源的同源核苷酸序列进行重组和定向进化方法产生hangtaimycin新结构衍生物。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸列序列可用于通过合适的异源宿主表达，获得更高产量hangtaimycin及其新结构衍生物；所述异源宿主包括放线菌、假单孢菌、大肠杆菌、芽孢杆菌、酵母或植物中任一种。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于特定蛋白的表达及其抗体的制备。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于提高特定蛋白的活性、优化蛋白的动力学特征。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：所述生物合成基因簇通过遗传改造产生可用于医药、工业或农业的hangtaimycin新结构衍生物。

本发明还提供一种如上述的hangtaimycin生物合成基因簇的应用，其特征在于：该生物合成基因簇的基因及其蛋白信息用于发现同类化合物、基因或蛋白。

概括来说，本发明的第二个目的是提供hangtaimycin生物合成基因簇的应用，包括以下几个方面：

(1)本发明提供的核苷酸列或部分核苷酸序列，可利用聚合酶链式反应(pcr)的方法或包含本发明seqidno.1所示序列的第1-91594位的dna作为探针，以southern杂交等方法从其它生物体中得到与hangtaimycin生物合基因簇相似的基因。

(2)本发明提供的核苷酸列或部分核苷酸序列，可以通过包括但不限于体内或体外插入、缺失、置换、突变、与其它来源的同源核苷酸序列进行重组和定向进化等方法产生hangtaimycin新结构衍生物。

(3)本发明提供的核苷酸列或部分核苷酸序列，可以用于通过合适的异源宿主表达，获得更高产量hangtaimycin及其新结构衍生物，这些异源宿主包括但不限于放线菌、假单孢菌、大肠杆菌、芽孢杆菌、酵母、植物等。

(4)本发明所提供的氨基酸序列，可以用于特定蛋白的表达及其抗体的制备。

(5)本发明所提供的氨基酸序列，可以用于提高特定蛋白的活性、优化蛋白的动力学特征或其它致力于得到的性质。

总之，本发明所提供的包含hangtaimycin生物合成相关的所有基因和蛋白信息，有助于人们理解hangtaimycin家族天然产物的生物合成机制，以及在此基础上通过遗传改造产生可用于医药、工业或农业的hangtaimycin新结构衍生物，本发明所提供的基因及其蛋白信息还可以用于发现同类化合物、基因或蛋白。

本发明的链霉菌streptomycesspectabiliscctccm2017417是已知菌种，公开于文献：functionalanalysisofcytochromep450sinvolvedinstreptovaricinbiosynthesisandgenerationofanti-mrsaanalogues.liuy,chenx,liz,xuw,tao,wuj,yangj,dengz,suny.acschembiol.2017,12(10):2589-2597。本申请人保证自申请日起20年内向公众提供该链霉菌streptomycesspectabiliscctccm2017417菌株。

附图说明：

图1.hangtaimycin的化学结构式。

图2.hangtaimycin生物合成基因簇。

图3.hangtaimycin生物合成基因簇敲除重组质粒。

图4.hangtaimycin生物合成基因簇敲除示意图。

图5.hangtaimycin生物合成基因簇敲除验证结果。

图6.hangtaimycin生物合成基因簇敲除突变株δhtmbgc发酵产物hplc检测结果；(a)突变株δhtmbgc，(b)野生型cctccm2017417，(c)hangtaimycin标准品；*表示在同样条件下未检测到hangtaimycin。

图7.hangtaimycin生物合成基因簇敲除突变株δhtmbgc发酵产物lc-esi-hrms检测结果；(a)突变株δhtmbgc发酵产物中hangtaimycin对应[m+h]+抽提和高分辨检测结果，未检测到hangtaimycin对应产物；(b)野生型cctccm2017417发酵产物中hangtaimycin对应[m+h]+(理论值m/z936.45018)抽提和高分辨检测结果；(c)hangtaimycin标准品[m+h]+(理论值m/z936.45018)抽提和高分辨检测结果。

图8.hangtaimycin的1h核磁共振测试结果。

图9.hangtaimycin的13c核磁共振测试结果。

图10.hangtaimycin的1h-1hcozy的核磁共振测试结果。

图11.hangtaimycin的hsqc核磁共振测试结果。

图12.hangtaimycin的hmbc核磁共振测试结果。

图13.hangtaimycin的1h-1hroesy核磁共振测试结果。

具体实施方式：

以下实施例是对本发明的进一步说明，而不是对本发明的限制。

1.链霉菌streptomycesspectabiliscctccm2017417基因组中hangtaimycin生物合成基因簇序列和功能分析。

通过对链霉菌streptomycesspectabiliscctccm2017417进行全基因组测序及生物信息学分析，定位了hangtaimycin位的的生物合成基因簇，它包含了21个基因(图2、表1)，其中htma1、htma2、htma3、htma4、htma5、htma6、htma7、htma8、htmb1、htmb2、htmb3、htmh、htmi1、htmi2、htmo、htmp、htms、htmt共18个是负责hangtaimycin碳骨架合成及修饰的基因，以及htmr1、htmr2、htmk共3个是负责调控和转运的基因。

表1.hangtaimycin生物合成基因簇中各基因编码蛋白的功能分析

2、hangtaimycin生物合成基因簇的功能证明

基于同源重组双交换技术，对链霉菌streptomycesspectabiliscctccm2017417基因组中包含hangtaimycin生物合成基因簇的91887个碱基对进行了敲除，通过产物分析，证明该基因簇是hangtaimycin生物合成基因簇。

表2.hangtaimycin生物合成基因簇敲除重组质粒构建引物及核苷酸序列

表3.hangtaimycin生物合成基因簇敲除突变株验证引物及核苷酸序列

表4.hangtaimycin的nmr核磁归属表

以下进一步提供实施实例，这些实施实例有助于理解本发明，仅用作说明而不限制本发明的应用范围。

下列实施例中未注明具体条件的实验方法，通常按照常规条件或链霉菌标准操作的条件或按照制造厂商所建议的条件。除非另外说明，百分比和份数按重量计。下述实施例中所使用的材料、试剂等，如无特殊说明，均可从商业途径得到。

实施例1

hangtaimycin产生菌链霉菌streptomycesspectabiliscctccm2017417总dna的提取：

取abb13固体培养基(可溶性淀粉0.5％，大豆蛋白胨0.5％，碳酸钙0.3％，3-(n-吗啉)丙磺酸0.21％，盐酸硫胺0.001％，七水合硫酸亚铁0.0012％，琼脂2％)平板上生长7天，大小约1cm2链霉菌streptomycesspectabiliscctccm2017417菌块，接种至80ml的tsby液体培养基(蔗糖10.5％，酵母提取粉0.5％，大豆提取物0.5％)，28℃，220rpm，培养48小时。将菌丝体6000rmp离心10分钟后弃上清，收集菌体。将菌体溶于15ml的set缓冲液(tris-hcl0.07％，乙二胺四乙酸0.73％，氯化钠4.39％)中悬浮混匀，重复离心和悬浮两次后，将菌体溶悬重新浮于10ml的缓冲液中，加入50μl的溶菌酶溶液(100mg/ml)，置于37℃水浴锅中温浴1小时。随后加入280μl蛋白酶k溶液(50mg/ml)，混匀后加入600μl10％sds，颠倒混匀后置于55℃水浴锅中温浴2小时，此期间每隔15分钟颠倒混匀，直至菌丝体裂解变透明。之后加入4ml5m的nacl，颠倒混匀，降温至室温后加入10ml的氯仿颠倒混匀至乳白色。6000rmp离心10分钟，取出上清液后加入0.6倍体积的异丙醇，混匀至絮状dna析出，将析出的dna小心挑出并用75％的乙醇洗涤两次，置于通风处吹干，溶于适量的超纯水中。凝胶电泳检测总dna大小，并测定其浓度和纯度。

实施例2

hangtaimycin生物合成基因簇敲除突变株δhtmbgc的构建：

(1)根据hangtaimycin生物合成基因簇核苷酸序列，在hangtaimycin生物合成基因簇htma4的上游和htmk的下游分别设计一对引物(引物序列见表2)。通过聚合酶链式反应(pcr)扩增获得用于同源重组的左右同源交换臂，长度分别为2061个碱基对和2060个碱基对，pcr反应体系和条件为：

95℃，3分钟

95℃，30秒；58℃，30秒；72℃，90秒；30个循环

72℃，5分钟

(2)用限制性内切酶ndei和hindiii双酶切大肠杆菌和链霉菌穿梭载体pyh7，回收其中约9000个碱基对，含有接合转移起始复制位点和氨苄西林抗性基因的dna片段作为载体，通过gibson方法与上述两条左右同源臂进行拼接，获得目的重组质粒pwhu-bgc(图3)。

(3)将重组质粒pwhu-bgc转入大肠杆菌dh10b感受态细胞，从转化子中制备的重组质粒经酶切和测序验证正确后，转入大肠杆菌et12567/puz8002菌株中。

(4)将含有重组质粒pwhu-bgc的大肠杆菌et12567/puz8002单克隆转化子接种于5ml含抗生素卡那霉素(kanamycin，50μg/ml)和阿泊拉霉素(apramycin，25μg/ml)的2×ty液体培养基(胰蛋白胨1.6％,酵母提取粉1％,0.5％nacl)，37℃过夜培养，将菌液按10％接种量接种于5ml含抗生素卡那霉素(25μg/ml)和阿泊拉霉素(12.5μg/ml)的lb培养液中，37℃培养3小时。

(5)将tsby液体培养基中培养48h的链霉菌streptomycesspectabiliscctccm2017417菌丝体用2×ty液体培养基清洗两次，取100μl与用2×ty液体培养基清洗两次的含有重组质粒的大肠杆菌et12567/puz8002菌体100μl混匀后涂布于含10μmmg2+的abb13固体平板上。28℃培养12小时后加入1ml含抗生素萘啶酮酸(nalidixicacid，25μg/ml)和阿泊拉霉素(35μg/ml)的无菌水进行覆盖，待培养基表面干燥后置于28℃培养，5-7天后可见明显接合转移子生长。

(6)将接合转移子涂布于含abb13固体培养基平板上，28℃下进行松弛培养，5-7天后可见明显单菌落生长。

(7)将单菌落分别涂布在含有抗生素阿泊拉霉素(35μg/ml)和不含抗生素的abb13固体培养基平板上，5-7天后选取在不含抗生素的平板上生长而在含有抗生素阿泊拉霉素的平板上不生长的菌株作为候选目标菌株，提取其基因组dna，并在敲除dna上下游区域设计一对引物(表3)进行pcr验证(图5)，验证正确的菌株即为hangtaimycin生物合成基因簇敲除突变株。

实施例3

链霉菌streptomycesspectabiliscctccm2017417中和hangtaimycin生物合成基因簇敲除突变株δhtmbgc中hangtaimycin的发酵提取以及高效液相色谱(hplc)和液相高分辨质谱(lc-esi-hrms)检测：

将sfm固体培养基平板上生长7天，大小约1cm2链霉菌streptomycesspectabiliscctccm2017417和突变株δhtmbgc菌块，分别接种至40ml的tsby液体培养基中，在28℃和220rpm条件下培养36小时，将菌丝体按照2％的接种量分别转接至40ml的sfm液体发酵培养基(大豆粉2％，甘露醇2％，大孔树脂5％)，在28℃和220rmp条件下培养108小时。将发酵液经6000rpm离心10分钟后，沉淀用40ml乙酸乙酯萃取3次，合并萃取后的乙酸乙酯经旋转减压蒸发，浓缩干燥后的沉积物溶解在1.5ml甲醇中，最后经0.22μm的微孔滤膜过滤后进行hplc(图6)和lc-esi-hrms(图7)检测分析。结果显示，与产生hangtaimycin的野生型菌株链霉菌streptomycesspectabiliscctccm2017417相比，hangtaimycin生物合成基因簇敲除突变株δhtmbgc未检测到hangtaimycin，证明了hangtaimycin生物合成基因簇的正确性。

hplc分离条件：a相为超纯水，b相为乙腈。0-20分钟,35-65％b；20-28分钟,65-95％b；28-30分钟,95％b；30-33分钟,95-35％b.33-38分钟,35％b。流速为1ml/分钟，检测波长245nm，柱温30℃。

lc-esi-hrms检测条件：thermoscientific公司ltq-orbitrapxl离子阱质谱仪，agilent公司hp1100hplcsystem液相系统。

液相条件为：a相为超纯水，b相为乙腈。0-20分钟,35-65％b；20-28分钟,65-95％b；28-30分钟,95％b；30-33分钟；95-35％b，33-38分钟,35％b；流速为1ml/分钟。

质谱条件为：正离子模式检测；离子源喷射电压：4.8kv；毛细管温度：275℃；毛细管电压：15v；鞘气：氮气，流速：45arb；碰撞气：氦气；检测方式：全扫描质谱(分子量范围100-1000da)。

序列表

<110>武汉大学

<120>hangtaimycin生物合成基因簇及其应用

<160>7

<170>siposequencelisting1.0

<210>1

<211>91594

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>1

atgcctgaccacatacccggcgcccgcgccgcgctagccgacagaaccgccctggtcacc60

ggggcgggtcagggcatcggagcggcggtcgccgaggcgctcgccgccgagggagcccat120

gtggtggccaccgaccgcacggccgacggcgtcaaggcgctggccgccgactgggccgcg180

gacccggcccggtggggtgagggcgcgggcaccgtcaccgccgaggtcatggacgtcacc240

gacgccgcgtccgtcgaggccgtggtggcggcggccgagcgcgcgcacggcccgctcgac300

atcctcgtgaacgtggccggaatcctccgccccggacccgccgccgaactcaccgacgcc360

gactgggcggacaccttcgccgtgaacaccagcggcgtcctccacaccgcacgcgccgtc420

accccggggatggccgcgcgcggccggggctgcgtcgtcaccgtcggctccaacgccgcc480

ggggtgccccgcaccggcatggccgcctacgccgcgtccaaggccgcggccgccatgtac540

accaagtgcctcggcctggagctcgcccgcagcggcgtgcggtgcaacgtcgtcgccccc600

ggctccaccgacaccgccatgcaacgcgccctgtggaccgacgaggccgccccgcagcgg660

gtcatcgacggcgaccccgccacgtaccgcaccggcatcccgctcggccggatcgcggaa720

ccccgggacatcgcggacgccgtggtcttcctcgcctccgaccgggcgcgccacatcacc780

atgcaggagctctacgtcgacggcggcgccacgctccgctgacgcgccgccgcaccggcc840

ccatcggccccctgtccccaccgccacaacgccctccttcttcaacagcacacccacgcc900

caccgtgtccgtacgcccgcacgcccacggaccgtgagagaaacggagaccctcgtgtcg960

acggcacccgatgtcgccacgcacgtcccggccccggccgcccccaccagggcagcggac1020

ccggcccgccggacggtggaagccgacccggcgcatcccgccgtgggggccgccaccgcg1080

ctcctcgcggactacgcgccaggtgcccgcttcctcggcacccccacccggaccctgctc1140

ggacagggcgtccacagcgaagtgccgcacgacgaaagaccgttggccgcacgcgtcgcg1200

gacaccctcgccgccgccagggaagcgggcgccgacgcgcccgtcgtcatcggtgcggtg1260

cccttcgaccagggcgcaccggcggcgctcgccgtgcccgtcgccctgcacaccgcgccg1320

ccgctggccgccgacccgctcgtcgccctgcccgcccaggcaccggccgccgccgactgg1380

cgcatccgccaggtgcccgcgcccgagcactacggcgcggccgtcggcgccgccgtcgac1440

cgcatgtggcggggcgagttcagcaaggtggtgctcgcccgcaccctcgaactcgacacc1500

cccgacagcgcggagccggtcgacgtcgccgcgatgctccagcgcctggcccgccgcgac1560

cccaccggctacaccttcgcgctgcccacgggccccgagcgcaccctcatcggcgccagc1620

cccgaactcctcgtgtcacggcgcggccggcaggtcgtcgccaacccgctcgccggatcc1680

atcccgcgcagcgacgacctggccgaggacgtgcgccgcgcggcggccctgctgcggtcc1740

tccaaggacctgcacgagcacgccgtcgtcgtcgacgccgtccaccaggcgctcgccccg1800

tactgcgccgacatgaccgtccccgccgcgcccaccctgatccgcaccgccgccatgtgg1860

cacctgtcgaccaccgtcaccggcaccctcgcgcggccggggacctccgcgctcgaactc1920

gcctgcgccctgcaccccaccccggccgtgtgcggcacgccgaccgacaccgcccgcgag1980

gtcatccgcgagagcgagcccttcgaccgcggcttcttcaccggcatggtcggctggggc2040

gacgcctccggcgacggcgagtgggtcgtcaccatccgctgcgcggaggccgagcggaac2100

tccctgcgcctgtacgcgggcgcgggcgtcgtcgccgcgtccgagccggcggcggagacc2160

gcggagaccgccgcgaagttccgtacgttcctcgccgccgtgggggccgagctgtgacca2220

ccgagacgcccccgaccgcggggccccggacgcccacctggcccgaggagttcgccgccc2280

gctaccgcgcggccggatggtggcgcggcgagaccttcgggaccatgctgcgcgagcgcg2340

ccacggcccacccggaccggacggcgatcgtcgaccccgccaccgaccgccgctggacgt2400

acggcgaactcgacgcgcgcgccgaccggctcgccgccgggatgctcgcccgcggcatcg2460

cgcccggcgaccgcgtcgtcgtccagctccccaacatcgccgagttcttcgaggtggtct2520

tcgccctcttccggatcggcgcgctgccggtcttcgcgctgcccgcgcaccgcgagacgg2580

agatcgcctacttctgccgcttcaccgaggccgccgcctacgtcatcgccgccgagcacg2640

ggggctacgactaccgcgccctggccgcgaccgtccgcgccgaggtgccgacgctgcggc2700

acgtgtgggtcgcccagggcgaaccgggggagtgcacggccctggacgacgtgcgcgccg2760

atggcgaaggccccgcggagctgcccgcgcccgcgccgcaggacctggccttcctccagc2820

tgtccggcggcagcaccggcgtgcccaagctgatcccgcgcacccacgacgactacatct2880

actccctgcgcggctccaacgagctgtgcggcgtcgacgagcacagcgtctacctgtgcg2940

tgctcccggccgcgcacaacttcccgctgtcgtcgcccggaacgctcggcgccctgtacg3000

ccggggcccgcgtcgtgctcagcccgagcccggaccccgagaccgccttctccctcatcg3060

cgcgcgaaggcgtcacgctcaccggcctggtgccgccgctcgccctgctgtggacccagg3120

ccgccgccaccaccgcccacgacctgagcagcctcgacgtcctcctcgtcggcggcgcca3180

agttcagcgaggaagcggcccggcgcgtccgtccggccctcggctgcacgctccagcagg3240

tgttcggcatggccgagggcctggtcaactacacccgcctggacgaccccgaggaagtca3300

tcgtcaccacccagggcaggccgatctcccccgacgacgagatccgcgtcgtcgacgacg3360

cggacgacgacctgccgcccggctccaccggacacctcctgacccgcggcccgtacacca3420

tccgcggctactggaacgcccccgagcacaacgcgcgctccttcaccgcggacggcttct3480

accgcaccggtgacatcgtccgcctcaccgacaccggccacctggtcgtcgagggccgcg3540

ccaaggaccagatcaaccgcggcggcgagaagatcgcggccgaggaggtcgagaaccacc3600

tcctggcccaccccgccgtccacgacgccaacgtcgtcggcgagcccgacccgtacctcg3660

gcgagcgcacctgcgcctatgtgatcctgcggcccggagccgagccgctgaagcccttcg3720

cgatgaagcgcttcgtgcgcgagcggggcctcgccgcgtacaaggtccccgaccgcgtcg3780

agttcgtggacgccttcccgcagaccggcgtcggcaagatctccaagaaggacctcagag3840

cggcggccgccgaacggcccgccacgccctgacgggcccggcccctcacctccgacccac3900

tgacccacacccggacggaacgcaccgcaccatggccctgcccaccatcacgccctaccc3960

catgcccgtcgccgcggacctgcccgccaaccgcgtcgactggaaggtcgacccggcccg4020

cgccgtgctcctcgtgcacgacctgcagaactacttcctgtccgcgtacgacgccggggc4080

cgcgccggtgcccgaactgctgcgcaacgtcagcgccttgaaggagcgcgcgaactccgt4140

cggcatccccgtcgtctacaccgcgcagcccggcggccagacccccgccgaacgcggcct4200

ccagcaggacttctggggcccgggcctgccggacgacccgcaggcggcggccatcgcggg4260

acccgtcgccccgggccccggcgaccaggtcctcacgaagtggaagtacagcgggttcgt4320

ccgtacgtccctcgcggacgacctccgcgcccagggccgtgaccagctggtcatcaccgg4380

cgtctacgcccacatcggcgtcctgatgacggcgtgcgacgcctggatgcgcgacatcca4440

ggccttcgtggtcgccgacgccgtggccgacttctccgccgacgaccacgccatggccct4500

gcgctgggccgcgggccgctgcgccgtggtcacgaccacggacgaggtcctgaagggcgc4560

ctgaccaccgacgcgcccctgaatttcagatgcttcgcaggtgcgtcggtccctaggctc4620

cccgccatggacagcaacggcaccgaccacctcctgaacgtcgtggacgtcgaggccacg4680

tgctggcccggctcaccgccgcccggcgcggtcagcgagatcatcgagatcggcctgacc4740

gtcgtcgacctggccgccgggcgacgcgtcgcccggcaccgcgtcctcgtacgcccggag4800

cgctccacggtcagcgacttctgcacggaactgaccggcctcagacagcacgaggtcgac4860

gcgggcgtccccttcaccgacgcctgccgactcctcgcggccgagcaccgggccggggtc4920

agggcctgggcgagctggggcgactacgaccgccgccagttcgcccggcagtgccgggcc4980

accggcacgccctacccgttcggcgcgcgccacatcaacgccaaggccgtcttcacggcc5040

gcgcacggactgcgcaaacgccccggcatggcgcaggccctgcgcatcgccgggctgccc5100

ctcgaaggccggcaccaccggggcgaggacgatgcctggaacatcgcggcgctcgtcgtc5160

ggtctcgtgggagccgggagctggccgtgaaccaagagagtgccaaggggagttcaagaa5220

tttcccactggtctacaccttgactggtatagaccaaggcgggttgactgcgccccagtc5280

cgtctcggccccccagcgtggctcgctgccgcatcgaggagtgaagagattgaacgagcg5340

caagccaagaagaggtgtcaccgcccggttccgcgaacgcgcgcggcggctgcggccgtt5400

gctcgcggcctcggcggccaccggcgtcgcggccctcctggccaccctgcttcccgcgtc5460

gaccgcggccgccgccccggccgcggcccccgcctgcgccaccgcctgggactcggggtc5520

ggtctacaccaacggctccaccgtgtcgcacgggaagcgcaactggcaggccaagtggtg5580

gacccggggcgagacccccggcaccaccggcgagtggggagtctgggtggacaaggggga5640

gtgcggcacgggtggcgggaaccccgacccgggcggcttcatcgtgagccaggcccagtt5700

cgaccagatgttcccgaacaggaagcccttctacacctaccagggcctggtcgacgcgct5760

gaaggcctacccggagttcaccaagaccggcagcgacaccgtgcgcaagcgcgaggccgc5820

ggccttcctcgccaacgtcagccacgagaccggcggcctcgtccacgtcgtcgagcagaa5880

ccaggcgaactacccgcactactgcgacaagacccagccctacggctgtcccgcgggcaa5940

cgacgcgtactacgggcgcggccccatccagctgagctggaacttcaactacaaggccgc6000

gggtgaggcgctcggcctcgacctgctgaacaacccctggctggtcgagcgcgatccgtc6060

cgtggcatggcagaccggcctgtggtactggaacacccagaagggcccgggcaaggtgac6120

gggccaccaggccatcgtcgacggccacggcttcggcgagaccatccgcagcatcaacgg6180

caccctggagtgcaacggcggcaatccggcccaagtgcagagccggatcaaccgctacca6240

gcagttcgtccagatcctcggcaccaccccgggcgacaatctgagctgctgacatcatcc6300

cgagccgccgcgccccgccggcacggggcgcagcggctcgggcctgcggagaaccagcgc6360

gatcgcgtcgttctccgcgcgttccggctcgcgccggctcgtcgtgcacccatactggcc6420

gccgtgcgggttgcgatgatgacagcgggctcccggggcgacgtcgccccgttcaccggc6480

ctcggcgcgggcctcgtccgggccgggcacgacgtgaccttggtgacgcacgacatgttc6540

gagcccctgacgcggggctccggcgtccgcttccatccgctgcccgtcgacccgcgggcg6600

gagctgcactccgagcgcggccagggcctgcaccgcagcggcaccggcgtgggcaagctg6660

ctgcgggccatgtcgatgggcagggccgtcgtggggcagttcaccgacagcctcatcgag6720

gtggccgaggacagtgacgtgctggtcctggccggtgtggtggccccgctgggctgctcc6780

gtcgccgagggcctgaagctgccgagcgtcggcgtcaatctccagcccatgcacgccacg6840

cgcgcgttcgcgcccccgctggccaccgtgcgctcgctcggcccggtgggcaaccgcctg6900

gccgggtacgcggtcaccgccctcatcgagcagatcttcacccgggccgcccgggaggcg6960

cgcgagcggctgcgcctgccgccgctcggcgtcggggccgcgcgccgcgcccgcgaacgg7020

cagggctggccggtcctgtacggcttcagcccgcaggtcgtggcccgccccgccgactgg7080

cgccccggcctcgacgtggtcggctactggtggccgcacgacgtccaggaccaactgccc7140

gcagaactcgaggacttcctcgccgccggtcccgccccggtctacgtcggcctgggcagc7200

gccaccgtccccgacccggcccgcctctgcggccaggtcgtgagcgccctgcgcgcggcg7260

ggcctgcgcggcgtgatccagcgcggctgggcgggcctgtccgccaccggcgacgacatg7320

ctcaccatcgacgacgtcccgcaccgcctgctcttcccccgcaccgccgccgtcgtgcac7380

cactgcggcgcgggcacgaccgccgcgggcctgcgcgcgggcgtccccgccgtgcccgtg7440

cccgtccagttcgacgagatgttctgggccgaccgcctcacggccctgggcacggccccg7500

tacccgctgcccctgcgcaggctgaccacccagcgcctcaccgacgccctgatccgggcg7560

acgggggaccccggccaccgggagcgcgcgcgccttgtggcaggccgcctggccgccgag7620

gacgccgtcggtcccgtacgggacctgctccagcgcatcgagagcggcgagcacggcgcc7680

cgcgtcccctgagccgcgctccggaagatcgtccgcttgacctcaagcaaacttgaggtc7740

atacgttctccccatggccggcacggagtgcgggcctcgcaccacagcaacgggagggga7800

cacaccatgtcgaaccagcagatcactgacgctcagctcgccggacagcccgccgcatac7860

gtgaccggtctcgcctacgaggcgctcatcgcgttcacccgggcccggcaggaggagaag7920

ggctacacccagccccagttctggctgctgcgcaacctgtcggagaacgacctctcgccc7980

gacgggcaggggatgaccgtgccccagctgcaggacgccatggcctcctacatccggccc8040

gaggacgatctggcggcggaggccgatgtgctcctggagcgcggctggctgacccgggac8100

gccgacggccggctgtggctcaccgaggagggggagcggacccgcgtcgacctcaagcgc8160

aacgcccccgcgatccgcgccgccctccaccagggcatcgacgacgccgactacgtcacc8220

acggtgaaggtgctccagcagctgatccgcaacgcgggcgggaagaccgcctgacgggcc8280

ggaggggccgggccgcccggcccggcccctccggcccggtgcgtgcgcggcaggtcagcc8340

gacgtagacctgcggcgtgcggtcccgccacgggacggcctgctccagctgggcggcgac8400

ctggagcagcaggtcctcgcggccgtgcgcggcgaccagctgcacgccgatgggcaggcc8460

ctcgcggctctggccgaggggcaggctgatcgccgggttccccgacacgttgaacgtggc8520

ggtgaagggcccgtacgtgaacaggcggttcagccacgagcgcgccgagtgcccgtcgtg8580

gtcgtagttgagggtcccgtgcggcgcgggcagccggccgagcgtgggcgtcaggagcag8640

gtcgtgctcctggaagaagcggccgatcgaccgcgtcaccacgttctgcgcctcggtcgc8700

ggacatcacgtcgagcagcgtgaactcctcggtctcggagagcacgcgccgcgacacccc8760

ctccagcgtcgcggggtcgggcctgcggggcgtgccgcgcagcacggcgccgccggtggt8820

gacgaccgtcagcatcgcggcctcgatgacggcgctgccgtcgacgtccggtgcggcctc8880

ggtcaccgcgtggccgatccactccaggacctggcccgcggtgaccgccgcctccgcgac8940

ctgggggtccaccgtgccgccggtccacggccgggtggtcagggcgatccgcagccgccc9000

ggggtcggtgcggatcgcctcggcgtacggccgggcgggcggcggcgcctggtacttgtc9060

gccgacggcgggcgcgcagacggcgtccaggaggtgggcggtgtcccgcacggtgcgcgt9120

gaccgcgaactccaccagctgcccgaaagcggtttcaccgctcatcggcccgcacggcgt9180

gcgccccaggcccggcttcaggccgacgaggccgcacgaggaggccgggacgcggatgga9240

gccgcccgcgtcgttcgcgtgcgccaacggcaccgcgcccgccgcgaccagggcggccgc9300

gccgccgctcgacccgcccacgccgcgcttcgggttccaggggttgcgggtcgggccgta9360

gcgcaccgactcggtggcgaagctcagaccgaactccggcgcggtgctctgcccgagcgc9420

caccaggcccgcggcccggaaccgggccatcaggtcgtggtcgaccagggcgtacgcgcc9480

ctggacggcgcggctgccgatggtgaacggcacgccctgcgcgaagggcccgctgtcctt9540

gatgacgaacggcaccccgccgaaggggccatcgggctcatgggccagggacgggtcgaa9600

cggcggctgcgtcagcgcgttgagctccccgtcggcctgctcaagggcgcgccgcgcaca9660

ggcctcgacctcggccgcgctcacctcgcgcgtccggatcagctcacgcagccccaccgc9720

gtcgaaggacgcgtactcgtcgagctccagcgctcccagctccttttaccgtgttcgtcc9780

gtgttccgtgttcgtccgttgctctcgcgtacggggaaggggtcagcggcccggcgccgt9840

ggcgccgaggtggtcggtgatctcccgcacgaccgactcggtgtgatcgccgaggaagaa9900

gtgaccgccggggaagacgcgcagccggaacggcgccacggtgtgctgcgcccaggccct9960

ggcctcggcgacgtcgaccagcgggtcgctgtccccggtcagcgcgaggaccgggcagtt10020

caggggcggacccggccggtagcggtaggtctcgatggcgcggtagtcgccgcgcatggc10080

gggcaggaccatcgccaggaccgcctcgtcggcgagcagctccgagtcggtgccgctcag10140

ccgccgcagctcctcgacgagcccctggtcgtcgcgcaggtgcacgtgctcctcgcgctg10200

ccgcgacggcgcccggcgcccggaggcgaacaggccgtgcaggatgacaccgcgtgcctc10260

caggcgcctggcgacctcgaaggcgaccgtggcgcccatgctgtgcccgaagaacgtcag10320

cggccggtcggccaagcctgcgagctcatcggcgagccggtccgcgagggtggaaatgtc10380

cgtgatgcacggttcttggaggcggtcctgccgaccggggtactgcacggccagcacgtc10440

cgccgctggtgagagcgcggcggagaacgggaagtagtacgtcgccgagccgcccgcgtg10500

cgggaagcagacgacgcgggcgcccgtctccggtgccggatggaaccgccggacccaggc10560

gctgccggtcgctgccatcacggtgcctcttctccgcgtcgtgccagtggcgcaggtcag10620

ccggggggtgtccggtcctgctggtggtgctcgggcgcgagtggtgcgcgagcgagggct10680

accctaagctccgcgcgcccccgatgtgacaccggagggggtccgggggcgctgaggtat10740

atttcgagccactgcggcgatcggctcgtgactccgtccccgcagctcgcacccactggg10800

tccgcgggccaccatgaattccggacaaccggaacacgcgactgccgtcgaggcatggaa10860

attggtgcttgacggttggccctttcgtgacgcagtgttgcgggacagtcgtcagtgagt10920

aggcgagttagacggctgctcgacggtgggaaacgccgggcacgggggacggggcgtacg10980

tacacatggttcagcagcgcactgacgtcattcggcacgcccgtctctccgatatgcctc11040

ggcttctcgaactcgaggagttgtgctgggcggagccgctgcgcgtctccgaagaagtca11100

tccggcggcgccttttctcctatcccgtcggtcagttcgtcgtcgagtccgacggcgcgg11160

tgcacgccgtcatctactcccagcgcatcgggagtccggacgacgtgttctccgcgacct11220

tcgacacggccgaccgtttgcaccgccccgacgggccggtcgcccaggtcctctcgctga11280

acgtcgacccgtcgaagcagagcttccgtttcggcgacatgctgctggaacacctcctga11340

cgtgggccgatggcgaggcgtccgtgcggaccgcggtcggcgtgacccggtgcagggact11400

tcggcaggcacccggaggcggagctggccgcgtacatccgcgcgacgaacgtacagggcc11460

gctgcctggacaccgtcctgcgcatgcaccagctgcacggcgccgagatccgcgcgctcg11520

tcccgggatatcggccgggcgatctggtcaacgagggaaacggcgtcctcgtcgtctacg11580

acctgtcggaccgtcaggagcgagtgcgaattctccatagcgaaggagagaagtccgcgg11640

cggcctccattccgcccggcggacaactggccgtagaaatacgggagttcttcgacgcta11700

tactcggcggcgactacgagggaatcgaacaccctatagaaagccctctcttcgagctgg11760

gattcgactccgcggggcttctggatcttcaggaaaagatcgaatcccgatacggaatcg11820

gactcgcccccctcttcttcttcgagcacaacaccggcgccttgatcgtttcctatctgg11880

aagatctcaggggcgaggaaacaagccatgcgccggacgcccggccgaccgccgtggccg11940

ccgcgcctgccactcccgctccgcctgccgctaccgccgccgctccgcctgtcgctcccg12000

cctcgcccgctgcggccgctcgggccgagcgctccgacgactcccgtgacgtggcgatca12060

tcggcaccgcgtgccgtctgcccggcggcatcgaggaccgcgccggactgtgggagctgc12120

tcacgtccggccgcagcgccgtcggcaccctgcccgaggggcgctggcagtggcccgacg12180

gcacggggcccgacacccaccccggcatcgaccgcggcggattcgtcaccgacgcggggg12240

ccttcgaggcgggcctgttccgcgtcaccccgtacgaggcgcggcacatggacccgcagc12300

agcgctggaccctcgaactggcctgggcctgcctggaggacgccggatacgcgccgggcg12360

ccgtcgcgggcacgcggacgggcgtcttcgtcggcgccagcggctcggactaccagcgcg12420

tcatggacgcccgcggcgtgcccgtgcgcgcgcacagcggcctggcgacctccatggccg12480

tcatcgccaaccgcgtctcgtacttcttcgacctgcgcggcccgagcgtccagctcgaca12540

ccgcctgctccagctccctcgtcgccgtgcacacggccctgcgcgcgctgcgcgcgggcg12600

agtgcgacacggccctggtcggcggcgtcaacgtgctgtgccacccggccaacagcatcg12660

cctaccaccaggcgggcatgctgtcgcccgacgggcagtgcaagaccttcgacgcctcgg12720

ccaacggctatgtgcgctccgagggcggcgtcgccctgctcctcaagccgctcgccgccg12780

cgctcgccgacggcgacccggtgcacgccgtcatcaagggcagcgccaccaaccacggcg12840

gccaggcgggcggcctgaccgtgcccagcgccgccctccaggcgagcctcgtcgaagccg12900

ccctcgccgacgcgggcgtcagcgcgcgcgacatcggctacgtggaggcccacggcaccg12960

gcaccgccctcggcgaccccatcgaagtccaggggctcaccaaggcgttcgccggaagcg13020

acgcgccctgcgcgctcggctcggtgaagacgaacctgggccacctggaagccgccgcgg13080

gcatcaccggactgctcaagaccgtcctcgccctccagcaccggcagctgcccgcctcgc13140

tgcactacgagcgccccaacccgcacatcgacctggacgcctcgccgttctccgtcgtga13200

cccgcctctcggactgggacctcgacgggcgccccgcccgccgcgccgggatcagcagct13260

tcggctcgggcggcagcaacgcccacgtcgtcgtcgaggagttcccggccgccgcggagt13320

ccccgcgcgccggagccgcgccgcacgcggacggccgcggcggcgaagggccctcgatgg13380

tcgtcctgtccgcccgcagcaccccccaactgctgcgccaggcccggcgcctgctcgacc13440

acctccggcaggagcgcccggccgacgccgacctgagggacatcgcgtacaccacgcagg13500

tgggccgcgcggagctgcccgagcggctcggcctgccggtgacgagcgtcgcctccctca13560

ccgcgctcctcgacgacttcgtggcgggcgtcccgtcgcccgccgtcctgcgcggccgcg13620

ccgagcgggacgccgcaccgcaggccgcccccggcgccacggccgaggacgtcctggccg13680

cgtgggtgcgcggcgccggtgtcgactgggaggcgcaccacgcaggcggcgcccggccgc13740

gccgcgtccccctgcccacgcacgccttcgaccgcgaccactactgggtcggcgacgaac13800

ccgccgccgacccgtcccgagaccgtgcggaccaggacctgcccgccgcgcaggccgcac13860

cccggcaccccttgctccagcgcgcgacgccggacgcggacgccctcgccgccttcgatt13920

ccaccctcgccgcggaggacttcttcctgcgcgaccaccgggtggcgggcgagccggtgc13980

tgcccgccgtcgcctccctggagatggcccgcgaggccgcgagccgtacgctgcccgccg14040

ccgacggcgcggaagtgctccgcctggagaacgtggtgtggtcgcggcccgtcgtcgtac14100

cggacgggacgcggacggtccgcacggtcctgacggagagcgcgaacggcccggccaccg14160

gccagggtccggccaccggggacgccccggcctcaggcgatgcgtcggccgcgggggacc14220

gcccggtcgccttcgagatccgtgccgccgacgtcgtccacgcgcgtggagtggcctcgc14280

gcacgcggacggccccgcccgagcccctcgacctcgacgccctgaagtcccgtacgggcg14340

cggcggtgctcgacatcgacgacttctacgccacgctgcgcgccaccgggctcgactacg14400

gccccgcgcaccgggcggtgcgcgagatccgcctgggcgacggcgaactcctcgccgcgc14460

tcgccgtgcccgacgaggtcgcggccaccctcgacgactacgtactgcaccccagcgtgc14520

tcgacggcgcgctccaggcggccttcgcgccggacgtccgggcggcggaagcgggcggcc14580

tcgcgctgcccttcgccctcgaccgcgtcgacgtccacggagcgacgccgagcgccgcgt14640

acgcgtggatccgcgcggtgccgaccgcctcgcgccaggtgcggcgctgggacctcgacc14700

tctgcgacgcccagggaaggatcttcgcgcggctgcgcggctactccatgcgcaagacca14760

cggaggccaccggggagccgggggccacgcacgacgtgacactgttccgcccggtatggc14820

gcgcggccgacgccccggcggacaccggggcgcccgcgcacacggcgaggctcgtgctcg14880

cctgcggcttcgacgaccggctcgacgaactgcgcggcctggccccagaagtaacgttcc14940

tggagccgcccgagcaggccgccgccacccggaaggccgccccggtggcggacgccgtcg15000

ccgagcacgccgtcgaactgctccgcgcggtacgcgggctgctcatcggcaagccgaccg15060

gatccgtgctcctccaggtcctcacccacgccgacggcgaacaggcgctccaccaggcgc15120

tttccgggctgctgcgcacggcccgcctggagcaccccgccctcgtcggccaggtcgtcg15180

cggtgcccgccgacgcctcggcggcacacctcgccgagatcctggaggcggagagccgcc15240

gcacggacgaccagcgcgtcagccacggcgacggaacccgcacggtcctcgcctgggaac15300

ccctggacgagagcgccgcgcccgaggcggcgcccgtgccgtggcgcgccggaggcgtgt15360

acctcatcaccggcggagcgggcggcctcggccggatcttcgccagggacatcgcgcggc15420

gcgcccccggagccgtgctgtgcctgaccggcaggtccccgctcggcccggcgatcgagg15480

cggagctggcggcgctgcgcgccgagggcgcgcaccccgagtaccacgtcctcgacgtca15540

ccgacgcgcgcgccaccgagcgcctcgtccgcaagctgacgcgacgtcacaaggccctgc15600

acggtgtcctgcacgccgccggagtcctgcacgacgccttcctccagcgcaagcccgtcg15660

cggagttccgccgcgtcctcgctcccaagctggccggctgccacgccgtcgacgaggcca15720

ccaagggcctcgacctggacttcttcgcgctgttctcgtccgtcatgggcgcgaccggca15780

acgtgggccagggtgattacgccgtggccaacgccttcctcgacgagttcgcacgccacc15840

gcgccacccgcgtcgccgcgggcgagcgcggcgggcggaccctgtcggtcgcctggccac15900

tgtggcacggcggcggcatgggcgccgacgaggacacccgcaaggccctgcggctgcgcg15960

gcggcttcctgccgatggccacggacgccgggatcgacgcgttccaccgcgccctggaca16020

gcgccgagccgcacgtcgtcgtctgggccggagagcgcgcggcgggcacgcgcgcgctcc16080

tggacgcggcacccgccccggagacggtcagggccactcccgacgccgggcgggccacga16140

gcaccgggcaggccacgggcgcgcccgacgagcgggccctgcgcgcccgcaccctggagt16200

tcgtcaaggcggagctgtgccgcctcacccagctgccgcccggcgagatcgacgacgccg16260

agcccctgggctcgtacggcatggactcgatcctggcgaccgagctgacggcgggcctgg16320

agaagacgttcggctcgctgccgaagacgctgctgttcgagtaccacacgctcgccgagc16380

tcggcggctacttcctcggcggccaccgggccgtcctggagcagatgttcgcggacggcg16440

gcgccgagcgggcggaggcacaccccgaagccgtggcgcccgagccgccgcgtgcggcgg16500

tcacgacggccctccgcgaggctcccgcagcggacgagcgcgccgccgcccccacggcgg16560

aggactccgccctggacatcgccgtcatcggcctgtccggccgctaccccgaagcgcggg16620

acgtccgcgagttctgggacaacctgcgcgccggacgcgactgcgtcgtcgaggtccccg16680

aggaccgctgggactggcgggagtactacgagcaggaccgcaccgtgcccggccgccact16740

acagcaagtggggcggcttcatcggcgaggtggaccgcttcgacccgctgttcttcaaca16800

tcgcgccgcacgaggccgactacctggacccgcaggagcggctgttcctggagcacgcct16860

ggaccgcgatggaggacgccgggtacacccgggagcggctcgggcgcgccaccggggacg16920

gcgccgccgggcgggtcggcgtgtacgcgggcgtgatgtggggccagtaccagctgctgt16980

tcccggacgcgggcgcgggccgcggcaacccgcacgccctcggcagcagctacgcgagcg17040

tcgccaaccgcgtctccttcgtgctgaacctgcacggcccgagcatgaccgtggacacca17100

tgtgctccagctcgctcaccgccgtggagctggcctgccgcgacctgcgcagcggccgca17160

cccggctcgccttcgcgggcggtgtgaacgtgaccgtgcacccgaacaagtacctgggcc17220

tgagcaccggccagttcatctcgagccagggccactgcgagagcttcggcgtcggcggcg17280

acggctacatacccggcgagggcgtcggcgtcgtcctgctcaagccgctgcgcgacgccg17340

agcgcgacggcgaccccgtctacggcgtcatcaagggcagcggcgtgtcccacggcggac17400

gcaccaacggctacacggtccccaacccgcgtgcccaacaggccgcgatccaggatgcgt17460

tgagcgagtccggcgtcgaccctcgggtcatcagctacgtcgaggcgcacggcacgggca17520

cgaagctcggcgaccccatcgagatcaccggcctgagccaggccttcgccgccgcgtccc17580

cggacggcacgggcaccggcaccggctccggcttgggcgccgacgcccggtgctacctcg17640

gctcggcgaagtccaacatcggccactgcgagagcgccgcgggcatcgccgggctcacga17700

aggtcctgctgcagctccagcacggccagatcgccccttcgctgcactccgcgacgctca17760

acccgcacatcgacttctcgcgcacgcccttcgtcgtcaaccaggaactgcgcgactggg17820

agcgccccgtcgtcgacggacggccgcagccgcggatcgccggagtctcctcgttcggcg17880

cgggcggcgcgaacgcgcacctgatcgtggccgagcacaccgaccgccgccccgcccccg17940

caggacacggcccgcagctgttcccgctctcggcgaaggacgacgcacggctgcgcgcct18000

acgccgagcggctgctggacttcgcgcgggacaaggccctcgcgcagggcaaggtcgagg18060

ccgccgacgtgacccccgcggacctcgcgtacaccctccagaccgggcgcgaggccatgg18120

acgagcgcctcggcgtcgtcgccgactccttcgccgcgctcgccgagaagctggagcgcc18180

acctggccggtgacaccgccgtcgacggcgtctgccgcggcaacgccaagcggggccgca18240

aggccctggccgtcgtccccgccgaggaactcgccgagaccgtcgcaactctggcgcggc18300

gcggcaagctgcccgagctcctggagctgtggacgcgcggcgccgcccccgactggcagt18360

ccctgcacgccgacgcggccgccgtgccgcgccggatcagcgcgcccacgtacccgttcg18420

cgcgcgaacggcactgggtaccggaggccgccgcacccgcttcgcctccgcccgccgcgt18480

ccggtacggcgtccggtacggcgctcttcctcaccaagcagtggcgccccgccccctccg18540

ccccgggccggtccgggctctccggtgtcctcgtcctgcacgaccgcgccacccggcacc18600

tcgccgagcggatcgccggactcgtcgacggcgccacgccggtggacgcgacggaccccg18660

gcgcggacggcgtcgtcgaccggtgtgccgcggcatgctccgccctggtcgacctgaccg18720

ggatcggcgacgacaccgccccggccgggggcatcgaccggatcgcggaggacagcgcct18780

ccggccgcgcgctcgcgctgctgcggcgcgtgctcgacgcgaaggcgtcgcgggacgtcc18840

tgctgctgttcgtgacccagggcctggagaccacccagggcctggagaccgcccagggcc18900

tggagaccgcccagggcctggagaccgcccagggcctggagaccgcccagggcctggaga18960

ccgcccagggcctggagaccgcccagggcctggagaccgccgacgccgccgcgtcccgcc19020

gcgtcccgctcgcgggggccgcgcgtgccgcgctctaccggctgctccagagcgagtacc19080

gcggcctcgcctcccgccacgtcgacctcgaccccgccgtgcgcgacgccgccgcgctcg19140

cggccgtcgtccacggggaactcctcgacgacggacgcgcgccggaggtctgccaccgcg19200

acggcacccggctcgcgcccgtgctcgccgaacccccggcgcccaccgcggcccggcgca19260

ccccgcccgccttcgcccccgacgaggtcctgctggtgaccggcggcacccgcggcatcg19320

gtctgctgtgcgcccagcacttcgtcgcccggcacggcgtacgacggcttgtcctgacgg19380

gccgcgagcccctgccgccgcgccacctgtggtcggacccggaggcctgcccgcccgccg19440

tacgggcgaagaccgacgccgtcgccgccctggaggcgcaaggcgtcgaggtgcgggtgc19500

tcgcgctgccgctggacgacgcggacgcggtggcgacggccgtcaccaccgtcgagtcga19560

cgctcgggccgatcgcgggcgtgctgcacgcggcgggcctcgtcgacacgagtaatccgg19620

cgttcgtccgcaagccggtggccgacatcgcccgggtcgtctcgccgaaggtcgacggca19680

ccgtgcacctgctcgcggcgctcgacccgcgcgccctgcgcttcgccgtcctcttctcgt19740

cggtctccgcggccctgccgggcctcggcgccggacagagcgactacgccatgggcaacg19800

ccttcatggactacttcgcccaggcgcgcgcccacgaactgcccgtcaccagcgtccagt19860

ggccgagctggcgcgagaccggcttcggcgaggtcacgaacaagacctacaccgacacgg19920

ggctgctcagcatcaccaacgccgaaggcctcgccttcctcgacgagatcctcaccgcgc19980

cgcgcggacccgtggtcatgccggtccgggtcgacgccgcccgcttcgacgcggccgccc20040

tcctggacgcgcgcccggcggccccggccgccccggcgccccaggcccgtaccgtcgagg20100

cccgccgggacaccgccgggaccgcgcccctcagggccctgctcaccggcttcctcagcg20160

acaccttcagcggcgaactgggcctgaagtcaggccagttggacgaggagacctcgtacg20220

ccgactacggcgccgactccatcctgctcgcgcaggtcctccagcggatccgccagcgcc20280

tcgacgtgccgctcgacccgtcggtcctcctggagtacccgaccctgagcgagctcgtga20340

cctggctgctcgacacctatcccgccgaggtcgccgcgcagttcggcgccgagccggagg20400

cgcggcccgcgccgaccgcccgtaccgcaccgcgcgtcacggacgaggggcaggaccgcg20460

cgggcgaccacagggtcgccgtggtcggcatggcctgccgcctgcccggcgcgcccgggc20520

tcgacgcgtactgggagctgctgtcccagggccgccgcgccgtgcgcgaggtgcccgccg20580

agcgctgggggcgggccaccggcttccgcgccgggctcgtcgacgacgtgtacggcttcg20640

acgccgggcacttcatgctgcacgccgaggacgtccgcgccatggacccgcaggccctgg20700

tcctcctggaggagagcctcaaggccgtgcaccacgccggttaccgggcggccgacctgg20760

agggctcgcgcaccggcgtgtacgtgggcgcccgcagcgggcagcggcccgacggcacgc20820

tggtggacggggcccgcaaccccatcatgaccgtgggccagaactacctggcggccaacg20880

tctcccagttcttcgactggcacggccccgccatggtcatggacaccgcctgctcgtccg20940

cgctcacggcgatgaaggtcgccaccgacgcgctggccgcgggctccgtcgacctggccc21000

tggtcgcgggcgtcagcctgctcgccgaccccgaggcgcacgagctgttccggcgccgcg21060

gactgctgcgtgaggacggcgcgttccacatcttcgaccgccgcgcgggcggcgtcgtcc21120

tcggcgagggcgcgggcgtggtgctgctcaagccgctggccgccgccgagcgcgacggcg21180

acaccgtgtacgccgtcgtcgaaggcctcgccgtcaacaacgacggccgcacggcaggac21240

ccgccacgcccaacctcaccgcccagaagcaggtgatgcgggaggcgctgcgccaggccg21300

gctgccccccgcaccaggtgggccacctggacgtcaacggctccggatccgaactcacgg21360

acctcctggagctgaaggccgtccaggaggtgtacggagcggaccgcaccgcgcccctgc21420

acgtcgggtcgatgaagcccaacatcgggcacccgctgtgcgccgagggcatcgccgcct21480

tcatcaaggtggcgctgatggtgcaccaccagcggaccgtgccgttcctctcgggcgagc21540

agcccatggagcactacacgatcgaccccgccgtactccacctgccccggcacgccgagc21600

cggtggacctggcgtacgcggcggtgagcagcttcgccgacggcggcacgaacgggcacg21660

tcgtcctgggccgccccgatgcgccccgccccggcagggaacagcggggccccgtgccgc21720

tcccggagctcgaccgccgcgacgtgcgcaccgacgcacccgtccgcgccggcgagcccg21780

aggccgccaccggggcacgggtgtggacgcggcgcgtcgacgcccgcgacgccgtcgtgg21840

acggacaccgcgtctacggacggcggctgctgcccggcctcgcctggatcgacctcctgt21900

acggctgctgcgccgacctcgcaccggacgcgtcccccgcccggctcgcgctgcgcgacc21960

tgtcgatctaccggccgctcgccgtggacgagggcgccgccgtggaccttcgtatcgagg22020

cgcgcgccacggccgcggacacctggcacatcactgtcaccgacgcggcgcgcggcgaga22080

ccccggcaccgtacgtgacggccgacgtgcacctcacggacggcgccaccgccttcgacg22140

cggcagttcctgccgacgtcctgcgcacccgtggcgagggggcgcgcgacctcggcgaga22200

tctaccggagcttccgctcgcaggagctcgtgcactcgggcgagatgaaggtcgtcggct22260

cggtgcgcaccacgtccgacgacatctgggtgagcgtggccgtcgacgagtccgccgtat22320

cgagtggggcggtagagcgttcgttccacccggcattgatcgacggcagcgcggtggcgg22380

ccagcgccgtcgccctgggcggcgagccgcggctcttcctgcccctgcactacgcctcgt22440

tccgggccgccgcgccgctgggccgcgcctgccacacgcgcgtgcggcgcagcgggatca22500

cccgcggggacgaactcctcaccttcggaatggagttctacgacgaccgcgggcgcaagc22560

tgggcgagctgaccgggctcaccaccaaggcggtgcgcgacgccgggcacatcgaccccg22620

cgcgggccaccgcgccgaagcccgaggccgcgccggtggaaaggaccgcgcccgtggccg22680

ccgctccggccgtcgccgctccggccgccgccgctccggctgtcgacgcgatgcggacgc22740

tcgtacggtccgtcgtcgccggtcgcctcggcgtgcccgaggaccggatcgacgcggacg22800

cgagctactacgcgctcggcctggactccgcgacgctgctgcggatcgcggcggagctgg22860

gggagcggctcggcacgaaactcgcgccgacgctgctgttcgagcacgcctcggtggcgg22920

cgctcgccgggcacctggcccgccaccacgagcctgcggcaccggccgaggcgtctggcg22980

tacccgcgcacgccgaggcgccgcgccccgtcgcggccccggccgccacggaagccgccg23040

gtgccgtcggttccgtcggtgccgtcggtcaggacatcgcgatcgtcggcatcagcggcc23100

ggtacccgaaggcgcgcggcctcgccgagttctgggagaacctcaagtccgggcgcgact23160

gcgtcggcgaggtgcccgaggagcgctggccgggcgacaccttcgacggcgagcgcaccc23220

cgtcggggcggccggtgtcccgcctcggcggcttcctcgacgaccccgactgcttcgacg23280

cggagttcttccagatatccgacgccgaggcggcccgactcgacccgcaggagcggctgt23340

tcctcgaagtgtgctgggaggccgtcgaggacgccggatacacgcccgcgggcctctccg23400

cggccgacggcggacggcgcggggccgtcggcgtcttcgccggggtcatgcacaaggact23460

acgtcctggtgcagcacgacgcggcggacggcgacccggccgtcccgcccgcgcccctgg23520

cgctgaacgccgcggccatcgccaaccgcgtctcgcacttctgcgacttccgcggcccgt23580

ccctcgcggtcgactccgtgtgcgcctcgtcgctgagcgccgtgcacctggcggtggaga23640

gcctgcggcgcggcgagtgcgacgccgccctcgcgggcggtgtgaacctctcgctgcacc23700

ccgcgaagtaccgcacgtacggcagcctcgacctgctggcgggcgagacgccctcccgct23760

ccttcggcgccgggggcgacggctacgtggccgcggagggcgtcggagccgtgctcctga23820

agcccctcgaccgcgcgctggccgacggtgacgccgtgtacgccgtcatcaagggcaccg23880

ccgtcaaccactcgggccggacccccggcatgcgggtgccgtccgtcgccgcgcaggcgg23940

agctcatcgagacctgcctggagcgcgccggggtcgacgccgggacgatcggctacctcg24000

aagcccacggcacgggcacggagatcggcgacctcatcgaagtgcaggggctgcgccggg24060

cgttcgagaagcgcacggacgccaagggcttctgcgccctcggctcggtcaagtccgcca24120

tcggccacgccgaggcggccgccgggatcagcgggctcaccaaggccgtcctccagctcc24180

accaccggaccctgacgccgctggtcggcggcgccgggaccaacccgtacctcgacctcg24240

ccgactcgccgttccggctccagacggacctcgcggagtggacggtggacgcgggctgcc24300

ccggcacgccgcgccgcgccggagtgagcgcgttcggcgccacgggcaccaacgcccacg24360

tcgtcgtcgaggaagcacccccggtgcgcgaccacgccctgagcggcgacgcggcgggcc24420

ccgtgctcgtaccgctgtcggcgaccgacggcgaccggctgcgcgcctacgcggacaagc24480

tgctgcgcttcctcgacaccaaggagggcgccgcgctcgacccggccgacctggcccaca24540

ccctccagaccgggcgcgtcgccctggccgagcgcgcggtgatcctcgcgcacgacctgg24600

acgaggtccgcgagggcctggaggccgtggccaacggcaccgggaccgacggcaccgggg24660

tccgggtgtggcgcgggcgcgtggcggagacacccgcggaggcacggctcctcgacgagg24720

acgacgtacgcgcggaactcgtcggccgatgggcggcgcggggcaagtgggccaagatcg24780

cggagctgtggctcggcggctacgccctcgactggcccgccccgcacggcacggcggccc24840

cgcgccgcgcgcacctgcccacgtacccgttcgccaagcggcgtcactggatcacggcac24900

cggcaccggcaccgggaacggccggcacggcacccaccgcgcaggcccccgcttccgaga24960

gcggcaccgtccactggcacttcgtgcccgacggcgcgcagccgcccgcgtccgcccacc25020

gggccgacctcccggcggaggagaaggcccgcggctacgtgcgccagctcgtcgccgccc25080

gcgtgggacgccccgcacgggacatcggcccgcacgcgggtctgatcgacatcggcctga25140

cgtcgctcggcgccgtcggcctcagcaaggacctggcggcgacggtcgcgcccggcttcg25200

tgcccagcgccctgttcgagtacggcaccgtcgccgaactcgccgggtacctgacggcca25260

cgtggcccgcgggcccggcccgtcttgtcgccacgcgcccgcaggccccggagccggacc25320

tgccgtccgcccggccggaggaacggcccaccgcgcccgacgtcctggacgtcctcgagt25380

gcctgcgcagcggcgccctgcacctcgacgacgccatcgcgctcctcgacgaagagagtt25440

acgagaagtgaagcacgagctcagcgccctcatcgcggactacaaggcgggcaaggtcag25500

cgcccgtgaggtcggcgacctcctgcgcgacctgcgcgagcaggcgggggagccgcagcc25560

cgccggggcgttcgcgtacccgctctccgagggccagcgcggactgtgggcgctccagcg25620

ggcgtacccggacatggccgcgtacaacgtgccgctgtgcttccgcgtcagcggcctgga25680

cgtggcggcgttccaggacgcctgccgggcgctgctcgtgcgccaccccgtgctcaccac25740

cgtgatcggccaggacgcgggcgagccgacgcagtccgtcgaccccgcccgcgcgctcga25800

cttcgcgcggatcgacctgacgggcaccgccgacgagggcgaggcgctcgccgccgtgga25860

gcgcgcgggcaagcgggtgttctccctgggcggggcggccgggcacgagggcgaaggcct25920

gttccgcgtccgcgtcttcgaccgcccggcgggcgagtcgctcgtcctggtcgtcgtcca25980

ccacatcgtcttcgacggcacgtcggcgacgctcctgatgagcacgctgttcgaggagta26040

cgaggcgcgggtgagcggcgtaccggcgaagggccgcgaccccgaggacaccgcgggctt26100

ccacgacttcgtccgcgaggagcggcgcaccctggccgcgcgcggcgccgagcgccttcc26160

ctactggcgcaaccggctcgccgcgcccctgcccgtcctcgacctgcccgcggaccggcc26220

gcacacggacctcgccgaccgcttcgccgggaagacgctcgtgaccgaggtgcccgcgga26280

actggccgcgcgcgtcgccgagttcgccaccgcgcggcggaccttcgtgtccacggccat26340

gctcaccgcctacgcggcgaccctggcgacgtactccgacgccggtgaagtcgtcgtcgg26400

catgcccgtgaacgagcgcgaaggcgacgccctcgcccggaccgtgggcctgatgatcaa26460

catggtgccggtccgcgtcgcgctcccgcccgacgagcccttcgaccggctcgtcacgcg26520

cgcccagcgggacgtcgccgacgacctgctgcacggccaccccttcccggccctcgtgcg26580

ggacctcgcgcaggacaccccggccgggcgctccccggtgttccagacggcgttcgtctt26640

ccaggacgtcctcgacggcatcgccgacgccgaccggccctaccggctcgtcgaggagct26700

gcaccaggaaggggagtacgagctctccgtcgaggtgtggcgcagcggcgcgggctacgc26760

gctgtactggaagtaccagccggagctctacagccgcgcgttcatccaggagctggcggc26820

ccgcttcgccgacgtcctggcggcggtgtgcgacgagccgcacacgaccgtggccgccct26880

gcggcagcgcggcgccgagcggtgcgtgcaggacctcgtcgaggacacggcgcggcgcac26940

cccggacgcggtcgccgtggccggtcaggaagaggtcctgacgtacgaggcgctcagcgc27000

ccgcagtgccgcgctcgcctcctgcctggtggcgcggggcgtgcgccgcggcgacctggt27060

gtccgtgctgctcgaccggtcgcccgacctcgtcgtgaccctgctcggcatcctcaaggc27120

gggcgcggcgtacgtcccgctcgacccggagctgcccgccgcccggctcacggacatcgt27180

gacggacagcggcaccccgctgatcgtgacccagacccggcacgaggcccgcgcccgcgg27240

cctcgcggagggccggggggccgccgcgcccgcgctgttcgtactcgacgaggagcggga27300

cgcgctcgcggccgccctcgccccggggcggtccgccgccgtgcccgtgaccgccgacga27360

cctggcgtatgtcatctacacgtcgggcagcaccggccgccccaagggcgtgatgatccc27420

gcaccggggcttcaccaacctgctcggctcgctgcgccgcgagcccggcatggacgcgac27480

ggacaccctcttcgccgtcaccaccgtcagcttcgacatggcgcaggtcgaactgctgct27540

gccgctggtgtgcggggcccgcgtctatgtctgcgacagcccggccatcaaggacgtgga27600

ccggctcaaggagcgcatcgcccgggtgcggcccacggtgatgcaggcgaccccggcgac27660

gtggagcatgctgttccactcgggctggcgcaaccccgagggcgtgcggatcttctgcgg27720

cggcgaggcgctgccccgcacgctcaaggagttcttccgcgacaccggcaccgaggcctg27780

gaacctgtacgggccgaccgagacgaccgtgtactccaccggcggcctcgtccgccacga27840

ccggccgaccaccatcggcaggccggtcgcccacacccgggtccacatcctcgacgagca27900

cctgcgcccggtgccccacggagagaccggcgaactgtgcatcgcgggcaagggcctggc27960

gaagggctacgtcaaccggcccgacctcaccgcggagaagttcgtcgaccacgacctggt28020

gcccggcggcaagctctaccgcaccggggacctggcccgctggaccgaggacggcgagat28080

cgactacctgggccggaaggacttccaggtgaagatccgcggctaccgcatcgaactggg28140

cgacatcgagtaccacttgggccgccaccaggacgtcgccgagtgcgtcgtcgtcgcgcg28200

cggcgaggacggcgccaagcagctcgtcgcctactacgtgccgggcggcgcgggcgcccg28260

ccccgacgccttcaaggaacacctgcgcgcgctgctgcccgcgtacatggttccggactt28320

ctacgtcccgctcgacgccgttccgctgacgggcagcggcaaggtggaccgcaccgccct28380

gatggggcgcgaggtgtccgccgccgcgcccgccccggctgcccgcccccagcgggccgc28440

gcggccctcccgtgacgtggagcgcgaggtcctcgcctgctggcaggaggtcctgaaggt28500

gcgggacctcaccccgtccgtctccttcttcgagtccggcggcaactcgctgtcggccgt28560

ggtgctcgcggacctgatcggccgccggctcggggtgtcgttcgcggcggccgacctgtt28620

caagtacgccaccccggccgctgtcgccgcgtacgtgcgggagcaggtgccggaccaggc28680

ggaggcggcccaggaggcgccggagcccgtcgcgcccgctcccgcgcagacgcagacgca28740

gacgcaggctccggagccggagccggagcgcgtgtccctgcccgacgacgccgtcgccgt28800

cgtcggcatctcctgccgcttccccgacgcccgcgaccactgggagttctgggagaacct28860

caagcgcggccacgcctccgcagggcgctggagcgaggcggagctgcgcgctgcgggcgt28920

gcccgaacgcgtcctgcgcgacccggacttcgtgccgctgcgctcggggctcgacggcaa28980

ggacgagttcgacggcgcgttcttccggctctcgccccagcacgtcgagctgatggaccc29040

gcagttccgccaggtcctgctgcacgcctggaaggccgtcgaggacgcgggccgcgacca29100

ccgggagatccccaacaccggggtgtacgtctccaccggcaaccaccactacggcgcccc29160

ggacgacaccgccgagacgcccgccgcggtcatcgaggacccgcggcagtacctgtcgtg29220

ggtgatgagccagagcggcaccgtcgcctccatggtctcctaccagctcggcttcggcgg29280

cccgagcatgtccgtgcactccaactgctcgtcctcgctgagcgccctcgccctcgcggc29340

ccgcgccgtgcagaccggcgagacggacttcgccctggtggcgggggcctccgcgaacag29400

cgtcgacgggctcggctacgtccacaaggcgggcctcaacctctccggcgacggccgcgt29460

caaggccttcgacgcggacgccgacggcatggcgggcggcgagggcgtcgtggccctgct29520

gatccgccgcgctgccgacgccgtcgccgacggcgaccacatctacggactgctgcgcgg29580

catcgccgtcaacaacgacggcggcgacgccaccggcttctacagccccagcgtcaacgg29640

ccagtcccggctgatccggcaggtcctcgaccgcaccggcgtcgacccgcgcaccatcgg29700

ctacgtcgaggcgcacggcaccggcacgaagctcggcgaccccgtggaggtcgccgcgct29760

caccgaggcgtaccgcgcgttcaccgacgacaccggctactgcggcatcggctcggtgaa29820

gaccaacctcggccacctcgacaccgcggccggactcgccggtgccgtcaaggtgctcct29880

gagcctctaccacgggcagctcccgcccacgctccactaccgcgagcccaacccccaact29940

gcgcctggacacctcgccgttccacgtcgtggaccggctgcgcgactggcccgcggacgg30000

cgggccgcgccgcgcggcgcagagctccatcggcctgggcggcaccaacgcccacgccgt30060

cttcgaggagtacgtccccgccgccccggcacgcgccgacgacgagggcgccccgcagct30120

ggtgccgctgtccgcccgcacccgcgacgacctcgtgcgcgcggccgccgagctgcgccg30180

gcacctgaccgggccgcgcgccgccgcgctgcgcctggacgacgtcgcgcacacgctgcg30240

caccggccgggtcgccctggcccaccgcgtggcgttcgtcgtgcgcgacctggaccggct30300

ggccgccgaactggacgcgttcgtacgggacccggaaggcgacgacaccgcgcgccgctt30360

cacaggccctgcggcgggctgcgccacggccgacgccgacgccacccgcaagcacaccgc30420

gcagctcgcccgcaggctcgccgacggcaagctgaagaaggccgcgaaggcctgggcgcg30480

cggcgccgaggccgactggagcccgctcgccgggcagcggcccgcccgccgcgtgagcct30540

gcccggatacgccttcgcgccggtggtccacccgtacccggtccgcgcgccgcggcccgc30600

caccgccgcgccccgcccggacgcggcccccggcacgccgctcgcgcacccgctgctgca30660

cgagaacgtgtcgcggctcgacggacagcgctaccgctcgtccttctccggcgccgagtt30720

cgtcctgcacgaccacgtcgtcgacggcaagaagctgctgcccgccgtcgcgagcctgga30780

gatggcctgcacggccgtgcggcaggccctgccggagacggccgggcggcgcaccgtcct30840

gaagaacgtgacgtgggcgcgcccggtcgtcgtggacgacggcggcaggcaggtggagtt30900

caccctcacccgcgacgagacggccccctccgggccgctgggcttcgccctcctgacgga30960

cggcgaccagctgtgcgtccagggccgcgccaccatcgacgcggccgcgccgccgccccg31020

cgtcgacctcgcggacctgcgcgaccggctgcgcctgcggcccctcgcgggcgaggacgt31080

gtacgcgcacatcgcccgcgcgggcgtcgcctacggccccggcttccgcctcgtgcacgt31140

gctgcaccggggcgagcgcgacgggcgccgcgaggtgctcgccgaactgcggctgcccgc31200

gcacctgcgcgccacggcggacgcgtacgcgctccaccccagcttcctcgacgccgccgt31260

gcacgcttcgctcggcctggacccggccttcgactccgccgcggccgggacggtcgcgga31320

cgggacgacgcgggtgccgttcgcgctcgaccggctcgacgcgcacgcgccgttcggcga31380

gacgatgtacgcctgggtgcgcccggcggcgaaccgttccgccgcggcggaacgcgtcct31440

cgacatcgacctcctcgacccggcggggcaggtctgcgccacgctgcgcggcctcgccta31500

ccgcgccctggccacgcccgaccgccgggagcccgagagcagggagtccgagcgccggga31560

gcccgagagccgggagtccgagcgccgcccggaggcgactcgcgcctcccggctgcgcac31620

gctgcttccggtgtgggagccccggcaccccgccgaggccccggccccgcagagccctcg31680

gggcgccgtgctcgtcctggacgccgaccgcaggctgcacgccgaactggcggtgctcca31740

cccgggccaccagcgcgtcgacctgcctgatggcgcgtccgccgacgacatcgcggggct31800

gatccgcaccgcctgcgcggccaccggcgggcggatcgcccggatcgtctgggtcgcccc31860

cgccgagacccccgacggcatggtccggggccaggagcgcggcgcggtccaggtcttccg31920

cgtcgtcaaggctctactcgccctcggccacggcacgcgcgacctcgcctggtccctcta31980

cacgttcggcacccaggccgtccgcgaccccgacccggtcgcggccacgcacgcgagcgt32040

ccacggcctggcgggcagcctcgcccaggagcacacgcgctggacgatcgacctcgtcga32100

cctgccgcacccggactccggcgacctcgtcggcgaccgcctcggcgaggagcgacgcct32160

caccggggtgcgccccggcaccacggtggccctgcgcggcggccgctggttctcccacga32220

actgctgcccaccaccgccctggaaccggccaccggcacctaccggcacggcggcgtcta32280

cgtcgtcatcggcggcgcgggcggcatcggcgagctgtggagccggtacatggtcgaccg32340

ctaccgcgcgacgatcgtgtggatcgggcggcgccccctggccgacggggtggagcggcg32400

cctcgccgacctcgccgagcgggcccgcgccgcgggcgcggcggccccctcgtacgttca32460

ggccgacgcgcgcgacgacgagagcctgcgggccgcgcacgcgcggatcaagcgggacca32520

cccgcgcgtcgacggcgtcgtgcactccgcgatcgtcctcgccgacaagaccctcgcgca32580

catggacgaggaccggttccgcgccgccctcgccgcgaaggccgacgtcggcgtccgcgt32640

cgccgacgtgttcggggccgagccgctggacttcctgctgttcttctcctcggtcgagag32700

cttcgtccgggcccccggacaggccaactacgccgccggatgcaccttcaaggacgccct32760

cgcgcacgccctgaaccggcgcggcaccaccgtcgccaaggcggtcaactgggggtactg32820

gggcgtggccggtgtcgtcagcgactccttctaccgcgagcggatggccgccgccggagt32880

cgactcgctcgaccccgacgaggcgttcaccgccctggagtccttcctcgcgggcgagca32940

cggccaggtcgccctgatgcgcaccttcggcgacgaggcgctgcgcggcctcgccctgga33000

cgaacaccagggccgccaccgccgcgcgctgccctccgtgcgcgacgccgtcgtgtccgc33060

gcaccgcgcgccgcacggcgaggtcgagcggctgcgccgcttcctgccgcacccgcgcat33120

gcgcgaactcaccctgaacctgctgtacgtgaccctccgcgacctcggcgccgcgcgccc33180

ggacggggccgggcacggcgtcctgccccggtacgcgcgctggctggaggagagccaccg33240

gctgttcgccgaggccggccccgccctcgccgccctggacctggacggcgccgccctgtg33300

gcgccagtggcgggccgagcgcgacggctggcagacaggcgccaaccagcgcgcgcaggt33360

cgacctggtcgagtcctgcctccaggccctgccggacgtcctcaccggcgtccgccaggg33420

caccgagatcctcttccccggctcctcgctgtcccgcgtcgagggcgtctaccggggcga33480

cccggtcgtcgactacttcaacgaccggctcagcatgctcctcgccgacgccgtgcgcgc33540

ctggggcacggccgagccgggccggcggctgcgcgtcctggaggtcggcgcggggaccgg33600

cgcgaccagcgtcaaggtcctggaggccctcgaaccgttcggcgaccgcatcgccgagta33660

ccactacaccgacctgtccaaggcgttcctgttccgcgccgaggaacgcctcaagccccg33720

ctacccgcacgtgaccaccggcatcttcaacgccgagcacgcgcccgggccgcagggcgt33780

cgacctcggcggcttcgacgtcgtcgtggccaccaacgtcctgcacgccaccgccgacat33840

ctcccgcaccctgcgcaacgtcaaggcgaccctgcgggagggcggcctgctcctgctcaa33900

cgagatgagccgcaacaccctgctcgcccacgtcacgttcggcctcgtggacggctggtg33960

gctgtaccgggacgccgccctgcgcatccccggcagcccggtgctctccgccgagagctg34020

gcgcgaggtcctggaggacgaagggttccgcaccggtgcccagccggacaccgaggccca34080

cgcgctcgggcagatgctgctcgtcgcggagagcgacggacggtaccgcacgccggacgg34140

cccgagcgccgctcaggaccaggccgcgccccgcaccaccgcccccgcgtacgagcccgt34200

cgcggcggcgcccggcgcggacgacgagggcgagctgcgcgcgcgtaccgccgactactt34260

cgagcggctgctgcgcgaggccctgcacctggcggacggggagctcgacccggccaagga34320

cctgcacgactacggcctcgactccatcctcgtgtccggcatgaacagcgccgtggcccg34380

ggacttcgaggacgtcagcagcaccctgttcttcgaactgcgcaccctggacgagctcgt34440

ggaccacttcgtggagcggcggcgcccggagctgcggacgctcttcggcctcgaccgggc34500

ggacgcccgcagcccgcaggccgacgccgcccgggcctccgacgcgtccctcgccgagag34560

ggccgtcgcgtacctcaccggcctcgtcgccgagacgctgaagctcgacccggagcggct34620

cgacgcggacgccgacctcttcgacctcggcctcgactccatcctcgtcgtccagctgaa34680

caacaccctcggccgcgacttcgaggacctcggcagcacgctgttcttcgaccactcgac34740

ggtccgggacgtggccgcgtacttcgcgacgacgcacgcggcgcggctggccgaggtcct34800

gggcacggcgacccccgcggcaccgccgacggaagccacccgtccggcacctctgaccgc34860

tgcggtcgagcccgcccccgcccccgccccggctcccgaggtccggccccggcccgagcc34920

gcactccggcgacatcgccgtcgtgggcctcgccgggcgctacccgggcgccgagagccc34980

cgcccgcctgtgggagaacctggcccgcggcgagagtgcgaccgcgccctacccggccga35040

ccgctggtggtgcgactggcaggaccgggagcgcccctggggcggcttcctcgacgacgt35100

ggcctccttcgacgccgcgtacttcggcatcgacgagcgcgaggccgcggccatggaccc35160

gcaggagcggctgttcatcgagaccgcgcacggagccgtgcaggacgcgggctacacgcc35220

cgcggccctcgccggacacggccgcgtcggcgtgttcgtgggcgtcatgaacgccacgta35280

caacgggcgcacggcctactcgtccatcgccaaccgcacctcctacctcttcgacttcca35340

gggcccgagcgtggccgtcgacacggcctgctccgggtcgctcacggccctgcacctggc35400

cgtgcagagcctgctctccggggacagcgcctgcgcggtggcgggcggcgtcaacctgct35460

cctcggcacggaccacttcgacgtgctccaggagcacggcctgctgtcgtcaggggagcg35520

gtgccgccccttctccgagcacgcggacggcttcctcgcggcggagggtgtcggcgccgt35580

ggtgctgcgcccgctgcgcgacgcgctggccgcgggcgaccacgtctacggcgtgatcaa35640

gggaagtgccgtcaactccggcggccgcaccagccgttacagcatgccgagcctggacgc35700

gcagcgcgacgtcgtcacccacgccctggccagggccggggtcacgccggacacgatcag35760

ctacgtggaggcccacggcacggcgacgcccctcggcgactccctggagatctccgcgct35820

cagccgcgccttcgccggtgaccgcccggggcagtactgcgcggtcggctcgctcaagtc35880

caacctgggccactgcgagagcgcctcgggcatcgcgggcctcaccaaggtcctgatgca35940

gctgcgccaccgcgcgctcgcgccctcgatcaacgccgaggacctcaacaccggcatcgt36000

cttcaagcagtcgccgttccacgtccagcgcgagctcgccccctggcacccggtcgacgc36060

cgaagggcgccccctgccgcggcgcgcgggcatctcctgcttcggcgcgggcggctcgaa36120

cgcacacctgatcatcgagggatacgagaacatggccgacgacgaggcccgcaccgccga36180

tgcgacggccgacgagacctgcctggtcccgctgtcggcgcacacgcccgagcaactgcg36240

cacggcggccgggcagctggccgcgcacctgggcgaggcggagcgcgagcggcgcccggt36300

gccgctgcgcgacctcgcgcacaccctccagaccggccgcgacgaactgcccgtgcgcct36360

cgcgctcgtcgtccgctccaccgccgaactcgccgcagcgctggccgagttcagcgcaca36420

cggcgtcgcgggacccggccggtacgccgacctcaccgaatccggcaccggcaccggtgc36480

acgggtgtcggcggtgggcggcgcggccggtgacccgcacgcggcggcgcgcggctggct36540

ggccggagcgagcgtcgcgtgggccgagctgcacgccgggcgcccgccgcgccgcgtcag36600

cctgccgacgtacccgttcgcacggcgcgagtactggtacgagcctgcgggggagcggcc36660

ccaggccggggagcgcgcgtccggcaccccggtagcggcacgccccgcaccgcaccccgc36720

accgcgcgccgaggacggcgcccacgacgtccgggcctggctgcgcgccgcgctcgccga36780

ggagctggacggcgtcgcgccccacgacgtcgccaccgaccgcgagttcgccgcgctcgg36840

cgtctcgtcgatgggcctggtgcggctctcccggcgggtgcggagcgagctgcacgcgga36900

cttcgcgtcggccgcgctcttcgagcaccgcaccgtcgacgccctggccgcccacctcgt36960

cggcgtactcccgcaggtggttcacacccccgatgcggtcgacgcgttcgtgccgcaccc37020

gctgtccgaggggcagcggggcctgtggagcctccagaagtccgcacccgacgcgagcgt37080

gtacaacgtgccgctgtgcttccaggtgtccggcctcgacctgccggccctgcgcaccgc37140

cttcgaccgggtccgcacccgccacccgctgctggcggccgtcgtacgacgggacggcga37200

ccgcctcgtgttcgcacgggccgaggccccgcggcccgcggtcaccgagcacgaactgac37260

cgcgacggaccccgacgaggtgcgcgcacagctgcgcgcgcacgccaaagagccgttcga37320

cctggagaacggcccgctgtgccggctgagcgtcttccacggcgctccgggcgcggacgc37380

ccgggtgctcctgaacgcccaccacctcgtcctcgacggcgcctccgccgtcgtgctcgt37440

caaggacctgctggccgcctaccggagcgccgccgcgggcgccgcgccggttccggccgc37500

cgcggccgccccgtacgccgagttcgtcgccgacgaggccgctctccaggccggggacga37560

gggcgcggaccggctcgccttctggcgcgagcagctggccgcgctgccgcccgtccccgc37620

cttccccacggaccggccgcgctccgcgcccgaccaggggcggcacggcgccaccgaggt37680

cctgcggctcccggtggacctcggcgaccgcgtcgcccggttcgcccgcgagcggggcgt37740

ctacccgtccgccgtgttcctggccgcgcaccaggtcctgctgcggcagtacgcccagca37800

ggacgacgtcgtcgtcggcatgccggtcagcacccggcccggcgcccgcttcgacggcac37860

cgtcggccacttcgtcaccatggtgccggtccggacccggatgtcggggcgcggcacgtt37920

cgccgagctgtgcgcggacgtccagggcacgctgctggacgccctcgcgcacgcctaccc37980

gttcggcccgctggtccgcgagctcggcctgggcacggccgacggctccgcgccggtgtt38040

ccgccacgccttcatgtaccaggactggcacgaggacgtcaccgcgggagcccccggcgt38100

ccgctacgtcgagggcgtccaccaggagggcgagtacgaactcgtcgtcgaggtcatcgc38160

gccgcacgccaccgaggacgcgtacaccgtcaaggcgaagtacgaccccgccctgttcga38220

cgccgcgacggtggaccggctgctgcgccagtacgcccacctcctggagtcggccccggg38280

cacggacccgctccggcggctcgacgactgctcggcggcctcgccgcaggagctgcacac38340

cctcaccgtggagtggaacgacaccgccgtcacccagccggacaagcacgtccacgagct38400

gttcgccgagcaggcggcccgcacccccgacgcgatcgcgctcgtggcgggcaccgagtc38460

cgtgacgtacgcgcgactggacgagcgcacccgggagctggccgcgcgcctgcgccgaac38520

cggcgtgggaccgggccgtctcgtcgccgtccacctggagcgctccgtcgacctcgtcgt38580

cgcgctgctcgccaccctgcgcgccgggggcgcctacatccccctcgacccggactaccc38640

gcgcgaccggatcgcccacatcctcgacgacgcagggcccgccgtcctgctcagccacac38700

cgcgctgcgcggacgcctcgcggacctggcggttccggccggtcggcgcctgctcgtgct38760

cgacgacccggacgccgacccggcggccgcggagccgagcggcgccgcgcccggcgcgca38820

ggatccggcctacgtcatctacacctccggcagcacgggcctgccgaagggcgtcgtggt38880

gccccaccgcgcgctcaccaacttcctgtgcgcgatggcgaagcggccgggcctcggcgc38940

ggccgaccgcgtcctcgcggtgacgacgcacagcttcgacatcgccgccctggagctcta39000

tctgccgctcgtcaccggcgccgagtgccacctcagcgacccggagaccgcgcgctccgg39060

cgaccggctcgccgcgctcgtcgcgcgggtgcggcccaccgtgatgcaggcgacccccgc39120

cacctggacgatgctgctgcacgcgggctggaccaacgccgaaggcctgcgcgtgctgtg39180

cggcggcgaggcgctgtccgagtccctcgcggagcgcctcaccgccctgggcggcgaggt39240

gtggaacctgttcgggcccaccgagaccaccgtgtggtccacggtcgcccgggtggaggc39300

gggccgccgcgtcaccatcgggcgccccatcgacaacacccggatccacatcctcgacaa39360

gcgcggcgccacggccccggtcggcgtgcccggcgagctgtgcatcgcgggcgacgggct39420

cgcgctcggctacctcaacaagcccgagctcaccgccgagcggttccccgccgacccctt39480

cacgccgggcggcaggctgtaccgcacgggcgacctggcacggcgccgcgcggacggcgc39540

catcgagtgcctgggacggatcgactcccaggtgaaggtgcgcggcttccgcgtcgagcc39600

gggcgagatcgagcacgccctcacccggcaccccgccgtgcgcgagtgcgccgtcgtcac39660

cagggccgagcccgcgacgggcgccacccagctcgtcgcctactggaccggcggcaacgc39720

caccgcgcgcgagctgaccgagcacctgcgccgggccctgcccgcgtacatggtgcccgc39780

gttcgtcctgccggtcgacgcgctgccgcagaccccgaacggcaaggtggaccggctcgc39840

cctggcccgccggccgatcacgctgccggacgcgcccgccccggagcggagcccggctcc39900

gccgaccgccgtcggcaccgtccgcgacagcgacgtgctcgccgtgtggcgggacgtgct39960

cggcgtcgccgggctccgccccacggacgccttcctggacgcgggcggcaactccgtcct40020

cgcggtggtgctcgccgaccgcgtcgccgagcgcttcggcgtgcgcttcacctcggcgga40080

cgtcttcggctgcgtcgacgcggccggtacggcagcccggctgcgcgcggacctcggcgc40140

ggcgcaccggccgggcgacgacgcggccccggccgccgacaccccgtcggccgatggcgc40200

gccccgtgccacggccccggccgcgccggagccgtccggccggctcgacggcgccgtcgc40260

cgtcatcggcgtctccgtcgggctccccggcgccgacgaccaccgcgcgttctggcgcaa40320

cctcgtcgcgggcacggagagcgtggagctgtgcacccctgacgagctgcgccgcatcgg40380

cgtcgacgaaggcctggtccaggacccggcgcacgtgccggtccgcgcgagcatgcgcgg40440

caagggcctgttcgaccacgccttcttccaggtctcggcgcgcgacgccgaactcatgga40500

cccgcaggcccgccagctgctccagcacgcctggaaggccgtcgaggacgccgcgtacct40560

gcccgccgacatcgccgacgcggcggtgtacatgtccaccgccaactccctctaccaggc40620

gcccgtcaccggccccggcgcccgccgcgactcggaggccctcgtcggcttcctccaggc40680

gcagcccggcaccgtgccgacgaccgtgtcgcaccggctcggcctgcgcggaccgagcct40740

gttcgtgcacagcaactgctcgtcggcgctcgccggcctcgccctggcctgccagggcat40800

ccagtcgggccagaccacgcacgccctggtcggcggctgcgcgatgtacggcgaggagac40860

cgtcggctacctctacgaggagggcatgacgctgtcgcccgacgggcactgcaagccctt40920

cgcggcggacgcccgcggcatggtcggcggcgagggagccgtcgtcgtcctcctgaagga40980

cgcccgcgcggcggtgcgcgacggcgaccacatccacgcgctcgtgcgcggcgtcggcat41040

gaacaacgacggtgcccgcaaggcgggttactacgcgccgagcctcaccgggcagagcga41100

actgatcgcctccgtcctcgaccgcgccggggtgcgcgccgagtccgtccgctacctgga41160

ggcccacggcaccggcaccgtcatcggcgaccccgtcgaggtgaacgccgtgtccgaggc41220

gttccggcgccacaccggcgccaccggcttctgcggcatcggctcggtgaaggcgaacct41280

gggccacctcgacgcggcggcgggcctcgcgggcctcgtgaagtccgccctcgtcctgag41340

ccaccgcacggtgccgccgaccatcaaccacgaggcgcccaacccgcagatcgacttcgc41400

gaactccccgttccacgtggtggaccggctcaccccgctgtcacccgcggacggccagcc41460

gctgcgcgccgccgtcagctccttcggcatcggcggcacgaacgtccacgccgtcctcga41520

agaggccccgccgcgcgacggcctcggcgcggacctcccggggccgcacctcgtccccct41580

gtcggcgcggacgcccgacgccctgcggcggtacgcccgcgacctggcccggcacctcac41640

cgacgaggcggccccggtggcggatgtcgccttcaccttccaggtgggccgcaccgccct41700

gccctgccgggcggcgttcacggccgcgaccacggccgaactcgtcgccgcccttgagga41760

cttcgccgagcgcgcgcagccgggcgcacagccgggcgcgcagccgaacacgcaggcacc41820

cgccgtcctcgacgtcctcgacgacgaggaccggcgcgccctgctcgaccagtggctcgc41880

cgagcgcaggctcgacaaggtggcccgcctgtgggaggcgggcgagcccgtcgactggcg41940

gcggctgtacgccgacgggccgcgcccgcaccgcctgagcctgcccgcgtaccccttcga42000

ggagcagcacttctggctgcgcgccgagcccccggcaccggtcgaggacgcctccgtggc42060

cccccgcctgttcgcggagcactgggtggcgcgcgacgccgcggcggtcgcggacaccgg42120

cgcccggcgcgtggtcgtggccttcctgtccgaccgcgcggcccaggacgcctaccgggc42180

cgcgacgctccggcacgcgcccggcacccgcctggtcttcgtcgccaggaccgacagcgg42240

caccggcaccggcaccccggagcccgcgcccggcgacgccggggccgcgctgacggggta42300

ccgcgtcgaccccgccgacgagcgcgccctcgcgcggacgctcgtcgccgtcgccgaggc42360

ccacggcccgctcgacgccctccactacctgtggcccaccgagcgcgcggacggcaggcc42420

gccgctgcgcgaactcgccgacgtcggcgtgctcgtacgggccgtcgccgccaccggcga42480

caccgtccctgacgtcctcgtcgcgggccactacgacgacgccgtgggccaggccgccct42540

cgacgccctgatcggctacgagcgctccctgtccgggccgctgcccggcaccgcgctgcg42600

cgtcgtgctgcacgagggcgccgtggccgcgggccgctgggccgagctgctcctgaccga42660

gcagcaccaggagcagaaggccgccgccctgtaccggggcgggcagcgccacgtctgcga42720

ggtgcggagcctgcccgacgccgccgcgcaccgcacgggtgccctgcgtgagggcggcac42780

gtacctgatcaccggcgccttcggcggcctcggccgccgcgtcgccgggcacctggcccg42840

cgcctaccgcgcgaacctcgtcctgctcggccgctcgccgctgagccccgccgacgagac42900

ctgggccgcggggctcggcgagcacggcggcgccgtcgtctgccgccgcgccgacgtcac42960

cgacgaggacgccctcgtcgaggcgctcagcaccctgccgcccgcgctgcgggccatcga43020

cggcgtcgtgcacgccgcgggcaccgcgcagcggctcgccgtgacggacgcgacccgcga43080

cgccgcccggcgcgtcctcgccgccaaggtggacgggacgctcgccgtcgaacgggccct43140

cgcccgcacgagcgccgggcgctccgcggagttcatctgcctcttctcgtccagctccgc43200

caccctcggcgacttcggcagctgcgactacgcggtcgccaaccgcttccagtcggccta43260

cgcgcgcgccctcgccgagcgcggcgagcgacggctgctcgccgtcggctggccgctgtg43320

ggaggacggcggcatgggcgccgccgcccagcgcgcggccgaccacgaccacgtcaccgc43380

gtacctggccgccagcggccagcggcccctcggcgccgacaccgcgctcgccgtcctcga43440

acggctcctcgcggaacggtccggcaccgccgcgcccctggtcctgcacgcgcccgccga43500

gcgggccatcgccctggccgagcgggccgtcgcgcccgcgccgcaccgcccgcgaccggc43560

ggcccccgcggccgccggccaggacccggcccccgcgcgggagccggccgcggtacacga43620

ccggcgtcgcgccgccctggccgacgcggtgcgcgaggtcgtcgcgcacgtcctgaagtc43680

ccccgcggaccagctggacgacgacagcggcttccacgacctgggcctggactccatccg43740

cctcacccagctcgcccaccggctcgccgaacgcctcggcacgccgctccagccgacggt43800

cctgtacgaccacccgtcggtacggcgcctgaccgaccacctggccgacgaaccggacgt43860

ccagctgcccgagtccgccgagcccgtcgtggctccgacggccccgcgccccgcccccga43920

agccgcccccgccgaccccggcaccgacagcgccgccgacgccgtcgccgtcatcggcat43980

gagcggcatcttccccggctgccgcgacgtggacgccttctggtccgcgctcgccgacgg44040

caaggacctcgtccgcgaactgccgtccgcccgcttcggcgcaccggcgaccggtgacgg44100

gggcgcgccgcggccctaccggtggatgggcagcatcgactgggcggacgaattcgacgc44160

cgccttcttcgagatcgcccccaaggaggcgcgcacgctcgacccgcgccagcgccacct44220

cctccaggagtgctggaaggcgctggaggacgccgccctcggcgcccaggagctggcggg44280

ccgcaaggtcggcgtgttcgtcggcgtggaacagggcgactaccagctcctcgacggctc44340

cggcggcaacctcacctcgaaccacgacggcgtcctcgccgcgcgcctttcgtacttcct44400

cgacctgaagggccccgtcctcgcggtcaacacctcctgctcctcgggcctggtcgcgct44460

gcaccaggcgcgcgcgagcctgctccagggggagtgcgacatcgccgtcgtcgcggcggc44520

gaacttcgtcctgaccccgcaggcgctcgccgccatggacgacgcgggcatgctgtcggc44580

ctccggccggtgcgccacgttcgaccaggacgccgacggcatggtccccggcgaggccgt44640

cacggccctggtccttcgcccgctggcggccgcggaggccgcgggcgaccccgtgcacag44700

cgtgatcacggccagcggcctcaactacgacggccgcaccaacggcatcaccgcgccctc44760

gggcgacgcccagcgcgagctcctggagtccgtgtacgagcggggcggcatcgacccggc44820

ggacatcggctacgtcgtgacccacggcaccggcaccaagctcggcgacccggtcgaggt44880

gggcgccctgcgcgcggccttcgcccggcacaccgacgagcgcgggttctgcgccctcac44940

ctcgaccaagaccaacgtcggccacaccttcgccgcctccggcctggtcggcctggtctg45000

tctgaccgaggcgctgcgccaccgcgccatcccgcccagcctgcactgcgagcgcgacaa45060

cgagtacatcgactggagcgccagccccttctacgtcaacaaggcgacgaaggagtggcc45120

cgccccgcgccacggccaccgcaccggcgcggtcagcgcgttcgggatgagcggcaccaa45180

cgcccacgtggtcgtacgggagtacaccggccggccggtcacggcggctccggcgcagcc45240

cgcctacctcctgccggtctccgccaagacggacacggccctggaggggatcgtcgacgc45300

cctcctcgaccggatcgcgagcggcgccctgacggacgccgacctgccccggctcagcgc45360

caccctcggcaccggccgccaccacttccggcaccggtgcgccctggtcgtgagctccct45420

cgacgaggccgccgcgctctggcgcggctggcgccgcgcgcggacggccccggccgacgc45480

gtgcttcgagggcgtcgtgccccgcggcttcaccgagcgggcgcaggacgccgaccggct45540

ccgggccgcggccgacagcgcccgggacaccgggctcgacccggccgcgcgacgggcggc45600

cctcgccgaggtcgcgcgcggctacgtcgcgggccacaccgtcccgaccgccgtaacccg45660

gcccgactgccgccccgtcacgcggctgcggctgcccgcgtacccgttcgcgcggaaccg45720

ctactgggtgcgcgccgagcagcagtccccggctccggccacggctgcggcgccggctcc45780

ggtcagcctgaccgcggcggagccggtcccggcgcccgccgacccggcccccgccccgga45840

gccgcgcaagcccgtcgtcctgcgggacttggcggacataccgcaccgaatcgacaccac45900

cgactcctcacccattgccgcgaagccgcaggtgtccctggcgcccctgacggcgtccgc45960

gcctgcccgtcccggcaccgcgcccgaggccgcggaggcacggcccgtcacccgcgacca46020

cgacgtactggaagacctcaaggcggcggccgacctcgacttcggcgggatggtcgccac46080

cctgaaccgcaccggcgtgatggtcgagcggctgatcccgtactcccaggagttcgccgc46140

gtacgcgggcgagagcggcggcgaggccctggacctgggctgcgcgtacggcgtggcgag46200

catcgccgcgctcgaacgcggggcgcgggtggtggcgctcgacatggagcagaagcacct46260

ggacatcctcggacagcgcgtcaacgacgaggcccgggagcggctttccctgcgccaggg46320

catgctgcccgacgtcgacttcgaggccgggcgcttcacggccgtgcacgccagccgcgt46380

gatgcacttcctcgccccggacgacttccggctcacgctgcgcaagatgtacgagtggct46440

ggcgcccggcggcaaggtcttcctcagctcggactcgccgtacttcggctactgggcgtc46500

caaggccgccgactacgaggcgcgcaagagcgcgggcgacccgtggcccggcttcatcga46560

cgacgtcgccgcgcacttcgaggcggcccacgtcgtcggcggtccgccgctgatcaacgc46620

gatcgaccccgacgtgttccgcagggagtgcgaggccgccgggttcgtcgtggagcgggc46680

cgggttcttcggcgccgtgggcgtggaccgggagtcgtacggcgcgcccgcccccgacat46740

ggagcacgtgggcgtcatcgcccgcaaaccggacgaaaaggccacagtgtccgatcccgc46800

ggccacctcggccgacggcacccgcatccgctaccggacgcgcggcaacggctccaccgc46860

cctcgtcctcatccacggcctcggctgcgacgcgtcgtactgggaccggcagctggagca46920

cttcgccgaccgctacaccgtggtcgcgcccgacctcgccgggcacggcggatcgggcag46980

ggcccggcggcgctggaccgtggaggcgttcgccgaggacgtcgtcgccgtcgtcgagca47040

ggagggcctcgacgacgtggtcctcgtcgggcactccctcggcgggcccgtgatgctggc47100

cgccgagcggctcctgggcggccgggtccgcggtctggtcggcgtggacacgctgcacaa47160

cttcgagcccaaggcgctctccgccgagcagctcgaccggttcgtgcggacgttcagcga47220

gcagccggtggaagcgcgggagctgttcctcgacggcgcgcgcgacgacctcgtcgccct47280

ggtcgcgcgcacccgcgaggagaccggggcggacgtggtgtccgccgcgttccgcgagat47340

gctcacctacctccaggacgtgcccaagcacttcgacgtgccgctcgtactgatcaactc47400

gacgtcctggatgccgacgaacctgaccgcggcgcgccgctacggcgtcgaggtggaact47460

ggtcgacggcgtcgggcacttcgtgatgctcgaggcgcccctcaccttcaacgcgaccct47520

gcgccgccgtctggagcagctcgttcctgacgtcgccgcaggtcaggacggcagcgggcg47580

cggagcccggacggaaggggccgattcctgatggccgcgccacgtattaagatccacgcg47640

aaaagcgacctgcatcggtacctgcgcgacacgctggccgtcgtccttggaaccgaagtg47700

gctccgagccgtgacgacgtgtccctcgtggagctgggtctcgattcgttcggctgcgcc47760

cagtggctgcacgaggtcaaccgaaccctcgggctttccctcacagtggcccaggtctgc47820

ggtcaccccacgttccgtacgttgtccgccctgatcgagggcgccatgggagaacagatg47880

agtgccacacccgctgggtcctctgccgcccgcggcacgtccgcgcccgggcgccaggcc47940

atcgccgcgcacctgcgtgagagcctcgcggcggagctggagctcgtcgcggcggacatc48000

gacgacgaggcgcccttcgtggagctgggcctcgactcgatcaccggtgtcacctggacc48060

cggaagctgaacacgcacttccagctgtcgctctccgcgacccaggtctacagccacccc48120

acggtcgacgagctcgcggggcacttggccgagctgctcggcggcggcgccgacgacgaa48180

ccggtgcaggctcccggcgatgctgagcccgagcccgttgaggcgacccccgtgggcccg48240

gacgcaccggcatccgcgcacgccgcggagtccgcgctcgccgcgtggctgcgggccagc48300

ctcgccaaggagctggagctcgccgcggccgaactggacgacgaggcgcccttcgtggag48360

ctggggctcgactcgatctccggcgtcacctggacccggtccctcaacacgcgcctgcgg48420

ctctcgctgtccgcgaccacggtctacgggcacccgacgatcagcgacctggcgcggtac48480

ctgacgcgggagcacggcgcggtggcccccgacgcgggggagggcacacggcccgaggcc48540

gcctcggcagcggagcccgagccgcagcccgccgtcgtcgagcccgagcccgtcgtagag48600

cccgagcctgccctggaagccgcgcccgccgctgcgcccgagcccgccgcggcagcggag48660

cccgagcccgcgccgcagcccgctgcccaggcgtccccggcacccgcccccggggccggc48720

ctcgtggacatcgccgtcatcggcatctccggcgcgttcccccaggcggagaacgtcgac48780

gcgttctggcggaacatcctggacggccgcgactgcatatccgaggtgccgtcctcgcgc48840

tggcccgtggagaagttctacgacgaacggcccggcgtgccggggaagtcctccagcaag48900

tggatgggcgtcctggagaacgcggaccgcttcgacccgctcttcttctccatctcgccc48960

ggcgaggccgaggccatggacccgcagcagcgcgtcctgctccaggagacctggcgctgc49020

gtcgaggaggcgggctacagccccgacgacctctccggcacccagtgcggcgtcttcgtc49080

ggctgctccgtgaacggctacggcgccacggccgacgcggccgggctcagcgcgcaccag49140

aacctcggcaccaacagcgccatcctcgccagccgcgtctcctacaccctgaacctcaag49200

ggcccctgcctctccatcgacacctcgtgctcgtcgtcgctcgtggccatcgcccaggcc49260

tgcgacagcctctgcctcggtgacagcgacaccgcgctcgcggccggcgtctgggtcatc49320

ccgggccccggcgtgcacgtggccatgagccagctgcgggccctgtcgcccgacggccgc49380

tgctacgccttcgacgagcgcgccaacggcttcgtaccggccgagggcgtgggcgtcctg49440

ctcctgaagcggctcgcggacgcccaggccgacggcgaccggatccacgccgtcatcaag49500

ggctggggcgtgaaccaggacggcaggtccaacggcatcaccgcgcccagcgccgaggcg49560

caggcccggctccagaagcacgtgtacgacaagttcggcatcgaccccggtgacatcgag49620

ctcgtcgaggcgcacggcaccggcaccgccctgggcgaccccgtcgagatcgacggcctc49680

gtcgacagcttcaccgcgcgcaccgaccgccgcggccactgcgccgtcggctcggtgaag49740

agcaacatcggccacaccgcgtgcgccgccggagtggccggcgtcctcaaggccaccctc49800

gccctggagcacgcgacgctgccgccgaccgcccagtacgagcgcctcaacgagcacatc49860

gacctggacggcacgcccttctacgtcaacacccgggcgcgcgagtggcggcgcgcggac49920

cggccgcgcctggccgccgtcagctccttcggctacagcggcacgaacgcccacgtcgtc49980

ctggccgaggcccccgacgccgcggcccctgcgtccgaacgccccggcggctcccgtctg50040

atcgccctgtccgcccgcacggccggacagctccaggaccaggcgcggcagctcgccggg50100

cacctcgaagcgcaccccggcctgagcctgcgcgacgtcagccacaccctggggcggggc50160

cgcaagcacttccgccaccgcctcgccttcgtcgtcgacagcacggcaggggccgccgcg50220

ctgctgcgcacctggctggagaccggcagcgcgccgtccgcgtacgccggtgaccacaag50280

ccccggcgcccggcgcggcccgacgtgcgggaggccagggaactgacggacccggaccgg50340

ctgcggacgctcgccgacgagtacgcccggggcgcggccgtcgcgttcgagctgctcttc50400

gcagccgaccggcgcccggcccggatctcgctgcccacgtacccgttcgcccaggactcc50460

tactggctgtccggcgaagccccttcgtccgacgagcctgccacggaggacgacgctgag50520

gacagggctgagggcgccgccgagaagccggaaggcccggtcgacctgctggccctggag50580

ccgtgctggacaccgctgcccacgccgcccgccgcccccgacgccgaaccggacgactgg50640

gccgtgtggctcgtcggccccggcgccgacgcggcggggcgcgcgctgcgcacccggctg50700

ccccgcaccgtggtgctgcacacgtccgaggtggccgcggaccgtccgctggacgccgcg50760

tacgcccgtctgatccgggacgtcctgggcgagctgcgcacccggatcgccgccggtgac50820

ctgccggacggcggcctcgcgcagatcgtcgtcctggggcacggcgccccggccgcgcgg50880

gtgctgaccggagtgaccgggctgctgcgcacggccgccctcgaacacccgtggctgcgg50940

gcccagctcctggagcacctcgaccccttcgacgccgccgacgaccggtccgtggccgcg51000

ctcgccgaagccgtcgaggcgggcgcccgcgcccacaccgagcagcacgtccgccagcag51060

ggcggcctgcggtacgccctgcggctcaccgaggtcgaggcgcggcccgcgcacggggcc51120

gccgcgtcgccgtggcgcgacggcggcgtgcacctgatcaccggcggcaccggcggcctc51180

ggcctgcacgtcgccggggagctgtcccgcaccctgcgcaccggcacggtcgtcctcgtc51240

ggacgctccgcccccgaggccgcacggccgcgcctcgccgccctcgccacgccgggcgtc51300

accgtcgagtaccggcaggcggacgtcaccgaccggcgggccgtcgacgcgctcgtcgcg51360

gacgtcgtctcccgccacggcgcgctgcacggcgtcgtgcactgcgccggagtgctccgc51420

gacggctacctcgccaccaagaaggacggggacctggccgccgtcctcgcccccaagacc51480

accggcctggtcaacctcgacgaggccaccgccgaccagccgctcgaccacctggtcgtc51540

ttctcctccacggcggccgcgctcggcagcgcgggccagggcgactacgccgcggccaac51600

gcgttcctcgacgcctacatggagtaccgcgccgacctcgccgcgcgcggcctcaggtcc51660

ggccgcgccgtgtccgtcggctggcccctgtgggccgacggcggcatgcggctcgacggc51720

gcgtccctggagcggctgcgcgggatcggcgtgacgcccctgcccaccggcgaaggactg51780

cgggccctgaccgcagccgtcgcgggcggcgcccggcacaccctcctgctctgcggcgac51840

cgcgagcggctgctcgaccgcctggccgcgcacatcaccacggagcggcagccgctgccg51900

acgcccgccccggccccggtcacggacgcgcgccccggccgccaggagtgggagcgcacg51960

ctggccgccgccgtctccgagcagctcaaggtccccgccgaagagatcgacggggacggg52020

gagttcggcgagtacggcttcgactccatcagcctgaccgagctcgtgcagcgcctgaac52080

gacgcccacgggctgagcctggcgcccaccgtgttcttcgagcacaccaccgtgggcgcg52140

ctcgcggcccacatcgccgagcacgcacccgcggcccacatcgccgagcacgcgccgacg52200

cccgccgagcccctgcccgccacggagccgacgcggcccgccccggtcgccgcggtcgtc52260

gcgcccgatctggacgcgatccggcaggccgtcatcgccgaggtgtccgggcagctgaag52320

gtccccgccgatgagatcgagggcgacggggagttcggcgagtacggcttcgactccatc52380

agcctgaccgagctcgccggccgtctcggcgaccggttcggcgtgcggctggcgcccacg52440

gtgttcttcgagcaccggaccgtggacagcgtggcggcacacctggcggagacggccccc52500

gcgccgacggtcccggccgccgaagtcccgtaccaggaagagccgttggagcacgccccg52560

gccgaggcgggcctctccgccgagcccatcgccgtcatcggcatgagcggcagcttcccg52620

caggcacccgacctgtcggccttctgggacaacctgtacgcgggcaaggactgcatcacg52680

gagatccccggggaccgctgggactggcgcgccctggctgaggacccggacgtcccgcgc52740

ggcaagaagcccgtgcgctggggcgggttcctcgacggcgtcgacacgttcgacccgctg52800

ttcttcggcatctcgccccgcgaggcccgcaccatggacccgcagcagcggctgctgctc52860

acccatgcctggcaggccctcgaagacgccggttacgcgccttccggtctggcgggaagc52920

gacaccgccgtcctgatcggcaccgcgccgagcggctacggcagcctcgtcatgggggag52980

cgggccggggaggacgggtacgccgcgaccggcgtctccggctccgtgggccccaaccgc53040

gtcagctacctgctcgacctgcacggccccagcgagcccgtggagacggcctgttcgagc53100

tcgctcgtcgccctgcaccgcggtgtcgagctgctccgctccggccgcagcggcctcgcg53160

ctcgtcggcggcgtcaacaccatcgtcagccccgacctgcacatcggctacagccgcgcg53220

ggcatgctgtgcgaggacggccgctgcaagacgttctccgcacgggccaacgggtacgtg53280

cgcggcgagggcgtcggcgtcctgctcctcaagccgctgcgccacgcccggcgcgacggc53340

gaccggatcctcggcgtcatccgcggcagcgccgtcaaccacggaggccgcgcccactcg53400

ctcaccgcgcccaacccgcgcgcccaggccgacctcctcaagagcgcctaccgcgacgcg53460

ggcgtcgacccgcgcaccgtcacctacgtcgaggcgcacggcaccggcaccgaactcggc53520

gaccccgtcgagctgaacggcctcaagagcgccttcggcgagctgtacgcggagacggcc53580

gaggcgcccggccgtctcgacgcaccggcccgctgcggcctcggctcggtcaagagcaac53640

atcggccacctggaactggcagcgggcgtggccggagtcatcaaggtgctgctccagatg53700

cgccacgccaccctggtcgagagcctgcactgcgcggacctcaacccgtatctggacttc53760

acggacagcccgttcgaggtcgtccgcgagcggcagccgtggcagcggccgcgcgacgcc53820

gacggccgggcgctcccgcgccgggcgggcgtcagctccttcggcttcggcggcgtcaac53880

gcgcacgtcgtcatcgaggaatacgtcgacgagcacgatgagcacgacgaggaccacggg53940

ggacacgcggccatggaaacgcacgccgacgcgcacacgggcaccgcgccccgggccggg54000

gcacccgcaccggccgcggcgctgatccccctgtccgcgcgcaccgaggagcagctcgtc54060

gcgcgggcccgggcgctgcgcgaccacctcagggccgggcacgaggcacgcctcgccgac54120

ctcgcgttcacgctccaggtgggccgtgacgcgatggaggagcggctcgcgacccgggtc54180

acctcgctcgccgacctggagcgcaggctgacgtcgttcgtggccgaccccggcgcccac54240

gacggctggcaccgcggcacggtgtcccgcaggaccggcgccgcgcaggacaccgggcac54300

cccctcgtggcgggggagcacgacgaagccctcgcccggtgggtgaccggtcacccactg54360

gactggcggagcctgtacgcgccgggggcccggcccgtgcgggtcggcctgccgacgtac54420

ccgttcgccgaggagcgctactgggcggggcgcgccaccgcgcccgccgccgggcccgcg54480

gccgcgcggccggacaccgcgcccgacgcgcacccgatgctgcaccagccggtgggcggc54540

accctgtcggcgtaccgcaccgtcttcgacggcgccgaacccttcctgaaggaccatcag54600

gtacgcggcctgcgcgtcctgcccggcgccgcgcacctggagatggcccgcgccgccgtc54660

gcccgcaccgcgggaacggcgggccgcgtccggctgagcgacgtggtgtggctgcggccc54720

gccgcctgcgccacggacgacggcctcgacgtgcgcctcgacctgaagccgacgggcacg54780

gacgcctacgcgtacacgctccacaccgtcggcgccgacggcgagcggacgctgtcgagc54840

cagggccgcgcccgcctggcggacgcgcccgccgagcgcccggcgctcccgctcgcggac54900

ctgcgcgccgcctgcgccgacgccgccttcaccgccgccgacgtctacggcctgtacgac54960

cgcgtgggcatggagtacggcccggcgcagcgctcgctcaccgccctcgccgtcggcacc55020

gacaccgcggggcgcccccaggcgctcgccgaactgcgcctgccccgggcggcggaggcc55080

accgacgcctacggactgcacccgagcatcctcgacggcgccctccaggccaccatcggc55140

ctcggactcggcggcggcgacggcgcggcccccgcacggcccgcgctgcccttcgccctc55200

caggaagcggacgtcctggccgccaccccggcgacggcgtacgcctggatccggtaccag55260

gacggcagccgccccggcgacacgtccgcgaagctggacatcaccctcctcgacgccgag55320

ggacgggtgtgcgcggagctgacagggctgctcgcacgggtgctgcccgccgatgcggcc55380

ccgaaggccgccgagccgaccgcgcgccccgccgcaccggccgtcggcaccccgctcgcc55440

cctctcgccgagcgcgcgctgccgtacctgcgcgaccagctcgccaccgcgctcgaagtc55500

gccgccgaacgcctcgacgtggacacgccgttggagttctacggcatggactccatgatg55560

gcgatggagctcacgcaccacctggagggcaccttcggggagctgtcgaagacgctgttc55620

ttcgaggtccgcaccatccgggcgctgagcgagcacttcgcagaggcgtacccgcagcgg55680

ctgcgcgccgccctcggcggccaggccccggaggctcaggaggccgacacgcaggccccg55740

gcccaggctccggcggggaccgccctcgcgcggccggacacgggccacgtcaccgacatc55800

gcgatcgtcggcgtgagcggccgctacccgctggcggagaacctcgacgagttctggcgg55860

aacctgcgttccggccgcgactgcgtcaccgaggtcccggcggaccgctgggacccccgc55920

gaccacgagggcacgtcccggtggggcgggttcctcgacggcgtcgaccgcttcgacccg55980

ctgttcttccgcatctcgccgcgcgaggcggagttcctcgacccccaggagcggctgttc56040

ctggagtgcgtccaccacaccctggaggacgccgggtacaccggcgagaccctgtcccgg56100

cagtccgccggacgggacggcgccgacgcgggcctcgtcgccaccggcaaggtcggcgtg56160

ttcgtcggcgtgatgtacgaggagtaccagctccacggcgcccaggcgcaggcgcgtggc56220

caccgcgtggcgctctccggcagcccgtcgtccatcgccaaccggatctcgtacttctac56280

gacttccacggcccgagcatggccgtggacaccatgtgctcctcctcgctgaccgcgatc56340

cacctcgcctgcgaggcgatcaggagcggtcagtgcgaggcggccgtcgcgggcggcgtc56400

aacgtcagcgtccacccgaacaagtacgtgatgctgagccagggcaagttcacctcaagc56460

gacggccgctgccgcagcttcggcgagggcggcgacggctacgtgcccggcgagggcgtc56520

ggcgccctcctgctcaagcccctggaccgggccgtcgccgacggcgaccagatccacgcg56580

gtcatcaagggcaccgccctcaaccacggcggcaggacccacggcttctcggtgcccaac56640

ccggcggcccagggtgacgtcatcacccgcgcgctcgcccgtgccggggtcgcgccgcac56700

gagatgagctacctggaggcgcacggcaccggcacctccctcggcgaccccatcgaactg56760

accggcctggtcaaggcgttcgggcggacgaccggggcgaccgcgccgacctgcgcgatc56820

ggctcggtcaagtccaacatcggccactgcgagagcgccgcgggcatcgcgggcgtcacc56880

aaggtgctgctccagatgcgccacggcgagctggtacccagcctgcacgcgagcaccctc56940

aacccccatctggacttcgacgggacgccgttcaccgtgcagcgcgacctcgcgccgtgg57000

cacgggccgcgcgtcgcgggcgtctccagcttcggcgcgggcggcgccaacgcgcacgtg57060

gtcctggccgcgtacgagcccgatgacgcccccgccaccccccggacgcgccccgtcgcc57120

gtacccctgtcggccgcgaccgaggaccaactgcttgaagccgcacggcggttgcgggcc57180

cgcgcggacggcctcaccgaggacgacctcgccgcgctcggctggacgctccagaccggc57240

cgcaccgcccttgaggagcgcctcgccttcaccgcggactccctggagtccctccggcgc57300

accctcgacgcgttcctggccgaccccgccgccccgggcgactgggtacgcgaccgggtc57360

agggccgaccgggccccggccgcggcggacggcgaagccaccggaccccaggagtgcgcg57420

gcccgctgggcgcgcggcgaagccgtcgactgggacctgctgtacgcggcggacggcacg57480

gcacgcccgcgccggctgagcctgcccggctaccccttcgcccgcgagcgccactggctc57540

gacctggagacggtgacgggccgtgagcccgccacgccggaccacgtcctcctgacgcac57600

cccgtgtgggaggccgaggagcccgcagacgcgacggccacgcccgcgcccgagcggcac57660

gtcatcctcgtcggccggttcgcgccgggcgaggagcccgcgctgaccacggccctgacg57720

gcggtgctgccgggcgcggtgcaccacgagaccgtggccctggccgccgacgcccccctg57780

gacaccgcgtacctgacggcggcacggcacgtgttcgcccgggcgcgcgccctcctgacg57840

gatggcgtgcgcggcggcgcgctgctccaggtcgtgctcgtcggcgaccgcggccaggag57900

gcggcgggtcggaccgtgttcggcggtctgagcggtctgctgcggaccgtggccctggag57960

aacccgaggctgcgcacccagctcgtggactgcctcgacggcgccgcgcccgccctcgtc58020

gccgagcggctgcgcgcggagacggcccccgagacggcgcccgaagtccgctaccgcgcg58080

ggccgccgcgaggtcaggcggctcacggagctggctcctgcgccggacgcgggcgccgcc58140

ccgtggcgcgcgggcggcgtgtacctcatcacgggcggcaccggggccctcggcctcgtc58200

acggcccgggacatcgcgtcggccgccgcgggcgccaccgtcgtactgaccgggcgctcg58260

gcgctcgacgacgcgcagcgggaggcgctcgacggcctgcgggccgcgggcctgaccgtg58320

gaccaccagcgcaccgacgtcaccgaccgcgccgacgtggaacgcctggtggcgcacatc58380

gcgcggacgcacgggccgctgaccggcgtcgtgcacgccgcgggcgtgctgcgcgacaac58440

ttcgtcgtgaacaaggcgcccgaggaattcgcgcgcgtcctcgcgccgaaggtcgcgggt58500

ctcgtccacctggacgagctgacccgggaccagccgcttgagctgttcctgtgctactcg58560

tcgacgaccggtgccctgggcaacgcgggccaggccgactacgcggcgggcaacgccttc58620

atggacgcctacgccgcccaccggggccgcctcgcggccgccggagcgcgccacggcctg58680

accctgtccctgaactggcccctgtgggccgagggcggcatgggcggggacgcagccgtc58740

gcggaccggctgcggcggatggacctcgtcccgctggacaccgagagcggtctgcgcgcc58800

ctgcgcaccggcgtcgccgcacgccgcaccggcctcgcggacggtcagctcctggtcgtc58860

gccgggcggcgcgacgcggtcctgccgcggctgaccgcgcgacccgggcgggcaccggcg58920

gccgagccgcgcgccggtgccgaggagcgggccgccgcgccgacgcctcccgccaccgcg58980

ccgacgtcccccgccggggcggcgggcggcgaccgggccctgctcgaccgcacccgccgc59040

cacctgcgcgcgcacctggcggcgggcctcaagctcggcgccgaccggctcgacgcggag59100

gtgcccctcgagcgctacggcatggactccgtcgtggcgatgaacctgatcgcccagctg59160

gagacggacttcggctccctgcccaagaccctgttcttcgaggtgcagacggtccgcgag59220

ctcgcggagtacttcgtcgccgagcacggtgacgcgctgcgcgcgctgttcggcgagacg59280

gtcgccgcggtgcccgcaccggagcccgcaccggccccgctcgccgccgagcccgcgaag59340

gcccagcgcgaggaggcgcagcccgccccagtaccgtccgccccggtaccgtccgccccg59400

gtaccgtccgccccggtaccgtccgccccggtaccgtccgccccggtaccgtccgcttcg59460

atcccgcccgtcgcgatcccgcccgtcgcgatcccgtccgtcgcggtcccgaccgtttcg59520

gtcccgtccgcacgggacccgcgcgacgagggcgtcgccgtcatcggcctcgccgggcgc59580

tacccgggcgccgccgaccccgacgccctgtggggcctgctgcgctccggcgccgactgc59640

gtcaccgaggtccccgccgaccgctgggaccacgacgcggtgttcgaccccgaccgcgag59700

gcggtcggcaagagctacggcaagtggggcggcttcctcgacggcgtcgaccagttcgac59760

ccgctgcacttcggcatctcgccgcgcgaggccgagaccatggacccgcagcagcggctg59820

ttcctggagacggtgtggcagctcctggagcagagcggcgtcacccaggaggccgtcgag59880

cgcacgtacggccgccgggtcggcgtgtacgtcggcgcgatgtaccagatgtaccgggcc59940

gacaccgccgacgtggtgcgctccgccctgacgtcggcggcgtcgtacaacctcatcgcc60000

aaccgcgtctcgcactacttcggcctggagggcccgagcctcgccgtggacggcatgtgc60060

gcgtcctcggcggcggccattcacctggcctgcgccgatctgctgagcggcgacagcgag60120

ctggccatcgcgggcggggtgaacctgaccgtccacccggacaagtaccgggcgctgtcc60180

cgggcgggcctgctcggcagccaccccggcagccgcagcttccgcgacggcgacggctat60240

ctgcccgccgaggcggtgggcgccgtcctgctcaagccgctggccgccgcccgcagggac60300

ggcgacaccgtcctcgccgtcatcaagggcagcgcctcgctgcacggcggccgcgcgggc60360

cagttcatggccccgagccgcaggacgcaggtgaacgtggcccgcagggccctggagaag60420

gcgggctgcgagcccgcgtcgatcggctacgtggaggccgcggccaacgggtccgcgctc60480

ggcgacgccgtcgaggcgggcgcgctccgcgaggtcttcggcgacgtcaccgagccgatc60540

gcgctcggctcggtgaagtccaacctgggccaccccgaggccgcgtccggcatcgcccag60600

ctcaccaaggtcatcctccagctccgccaccgggagctggcgccccgcaccgcggtcggc60660

acgcccaaccccgaactccgcctggacgagggtccgttgcggctgtgcgagacgctgacg60720

ccctgggagccgcgccccggcacgccccggcgcgcgctgctcaactccgtcggagcgggc60780

ggcagccacgtcagcctcgtcgtggaggaggcgccggagcccgagcgcccggaggccaac60840

cggccgcagccgacgcggcctgagctgatcctgctgtccgccggtgaccccgagcggctg60900

cgcaccgcggcccgcctcctgcacgacttcgtcgagcggagcgacgcaccgggcgcggac60960

gccgccgcctggctcgccgacgtcgcccacacgctgcgcgtgggcagggaagcacaggcc61020

gagcgcctggcgttcgtcacggactcccgcgcgggcctgctgcgcacgctcgccgatttc61080

ctggcggaccggcccccgtacggcccgctgtaccggggcgacgcggaggcggggggcgcc61140

accctgggcgacctgctcgcgggcggccacggcgaggcgttcgtccgcgcgctcgtgacc61200

gacggcgaactcgaccggctcgccgagctgtgggtgcgcggcggccggatcccctggcgc61260

gcactgcacaccgggcaggggcgccgactcgtaccgctgccgacgacggcgttccggcgc61320

aagcggtactgggtggggcacacgggtacgccgacggcggccacagacacccccgcggcg61380

gccacagacatctccacggcggccacgggcacgctcgcggcggctcccgcacccgacgcg61440

gccaccccgcacaccgaccagcaccccgaccccgtcgccgaacccgacggcgccgggcgc61500

ggcgacgacatcctgcgctacctcgcggactacttcagcgacgccctcggcttcggcccc61560

ggcgaactcccgctggacaaggacctgcacagcctgggcgccgactccgtcctgtgggtg61620

cgcctgcggcgcgcggtggagaccgacctcggtctcaccctcaccacccgggagatcgtc61680

gaactcaccaccctggagcgcatcgcggaccggctcgccgcgaagcgcggaaccccgcag61740

ccacccgaagcaccggacgtacgcgaagcacgggccaaggccctggagcagttccgccag61800

ggccacgtcggactcgaagaactcaagtcactcatgaaggaagcaccgggcgcgtgaacg61860

aggatcagattctggcgggcttcaaggcgggcctctacaccgctgaggacgtgctcgcgt61920

tctacgaacgactccaggactccgcgcaggcgggcgtcacggaccggcgtgccctctccg61980

agggccagaaggggctgtggctgctccacaagctgcggcccgcgtcggacgtgtacaacg62040

tccccgtctgcttccgcacgtcggcgccgttcgacgtcgcggtcttcgaggaggccttcc62100

ggcaggtgacgtcccggcacgcgctgctgcacagcgtggtcgtcgaggacgagggcaccc62160

cgtacctggtgcggcgccccgacggcggcgacgcgcccttccggcaccagaccgtgccgc62220

aggggctgcccgacgacgtcctgctcgccctggcgcgcgagcaggccaaggcgcccttcg62280

acctgcacgaggagggaccggcccgggccgtcgtgtacacggcgggcacggccgaggcgc62340

cgcagaccctcgtgctgctcgtcctgcaccacctggtgttcgacggcgcctcgacccccg62400

tcctgctgcgcgacctgctccgcacgtacgacaccctgctccagggcggcacgcccgagc62460

ccgcggccgcgcggcacgacgcctacgacgcgttcgtgcgctgggaggcggacttcctcg62520

cgggccccgaaggcgcccgccaccgcgccttctggcaggacaccctggcgggcgacctgc62580

cggtcctccgcctcggcatcgagcgcgcccccgcgcccggcgccgccgtggtgggcgaga62640

ccgtcgccctgccgctgcccccggccctcgccgcccgcgtgcgcgacctgtgcgcggccc62700

gcggcgccaagcccgcggtgctcttcctcgccgtgtacgaactgctcctgcaccgctaca62760

gcggcgagcgcgacctcattgtcggcgtgccctccctgggccggccggacgcgacctacg62820

acgacgcggtcggctacttcgtgaacatgctgcccgtgcgccacggcgtgcgcggcgacg62880

tgccgttcacggacttcgtgcgcgacctgacgctcgtcatggccgacggcctcgaccacg62940

ccgcgtacccgttcccgcgcatggtgcaggacctgaacctgcgcacggaccccgacacct63000

ccccggtcttccaggtgtcgtacgtcttccagaaccagcgcatgatgcacgtcacggacg63060

gcgacgtgctcggcctcgacctggcccgctcgctgcggttcgtggaggagatatcccagg63120

agggggagttcaagctccacctggaggtcgtcgagcacgccgccgacgcctacacgctgc63180

acctcaagtacgacgccgcgcgcttcgacgcggcggacgtcgagcgcttcctcggccact63240

acgagaccctcctgagcgccctcgtcgacgccccggagcagctgctttccgaggcctcgc63300

acctgtcggacgacgagctgcgccgcttcgacgcgtggaacgacaccacccggcccttct63360

ccgccgagcgcagcctgcccgacctgctcgccgacgccgtcgcccgccacggcgaccgca63420

ccgccctcgtgtacggcgagcgctccctgacgtacgccgaactcgccgagcgcaccgacg63480

ccctggccgccgagctgcgccgccgcggcgtcaccgcggacaccgtcgtcggcatctcca63540

tggaacgctccatggagatggtgatcgccctgtgggcggtcatgaaggcgggcggcgcct63600

acctcccgctcgagccggactacccggccgaacgcatccagtacatgatcgaggactcgg63660

gcgccgccctcgtcctcgcccagtccgcctccgacgtctccgccctggccggggcgcgca63720

cggtgctccgcctggacaccgaaggacggccggtccccgacggcgccccgcgcgcccagg63780

acccggcagcccccgcccggatcgcccccggcgacctcgcgtacgtcatctacacctcag63840

gctccaccggccgccccaagggcgtcatggtcgagcaccgcgctgccgtcaaccgcgtcg63900

agtggatgcagaacgagtacgcgctgacccccgacgacgtcgtgctccagaagacgccgt63960

tcagcttcgacgtctccgtgtgggagttcgtctggccgctgatcacgggcgcgcgcctgg64020

tcgtcgccgcgccgggcggccacaaggaccccgcgtacctggtgtcgctcatccgcgccg64080

ccgaggtcaccaccgcgcacttcgtgccgcccatgctgcgcctcatgctcgaccacgagg64140

gctgggcgcgctgcacctcgctgcgccaggtcttctgcagcggcgaggccctgccgccgg64200

agctgcccgcgcggcactacgcccagcaccgcgcccgtctgcacaacctgtacggcccca64260

ccgaggccgccatcgacgtcacccactgggcctgcccgcccgacaccacggcgcgcgcgg64320

tgccgatcggccgcccgatccagaacatccagctgcacgtcctggacgacctgggccggc64380

tgcaggccgtgggctgcgcgggcgagctgcacatcgcaggcgtcggcctggcccgcggct64440

acctcaacaaccccgctctgacgcgcgagcgcttcgtcccgaacccgttcgccgcggacc64500

cggacgcccgcatgtaccgcacgggcgacctcgtccgccggctgcccgacggcaccctgg64560

agtacctcggccgcatcgacaaccaggtcaagctgcgcggcttccgcatcgagctcgacg64620

agatcgaggaccgcctcgcccgccaccccgccgtgcgggcctgcgccgtcctcgcccgcg64680

aggacagccccggcagcccgcggctcgtcggctacgtcgtcctcgacgaggcgcacacgg64740

gggagttccacgacaccctggtgcgccacctcgggcagtcgctgcccgagtacatggtcc64800

cgggcgccctggtccgcctcgacgccctgccgctgaccgccaacggcaagctcgaccgga64860

aggcgctcccggcccccgacgccgacgcgtacgccgtggccggtgaccgcgtcgccccgc64920

gcacgcccaccgagcggaccctgctcgcggtctgcgcgggcctgctcggcttcgacgagg64980

agcgcatcggcgtccacgacaacttcttcgccctcggcgggcactcgctgctcatcccga65040

agctgaccgcgcgcctgcacgacgcggggctcgactgcgagctgcacagcgtgttcgccg65100

ccgccacgctcgccgacctggccgccgcgatcgacgcggcgcacgccaaggcggaccccg65160

gcgcgcgggacgcggcggacgccgccccggcgcggacggcgttcaccgtaccgccgaacg65220

gcatccccgaggactgcgaccggctcaccccggacatgctgcccctggtctccctgaccg65280

aggacgagctggcggcggtcgtcgccgccgtgcccggcggcgcgcccaacgtccaggacg65340

tgtacccgctggcggccctccaggaaggcatgctcttccaccacctcaaggagagcggcc65400

gcgacccgtacgtgctctccggcgtgttctccttcgagagcaggtcccacctggacggct65460

tcgtgcgcgccctgcgcgcggccgtcgcccggcacgacgcgctgcgcacggcgatcctca65520

cccagggcctgtcccggcccgtccaggtcgtggtgcgccgcgcggagctcgacctggagg65580

agttcgaggtgcccgcgggccgcgacgccgagggcgagatccgcgaactcctggcccggc65640

cgcaggcgatgcgccttgaccgcgccccgctgatccggctgcgcgccacccggcagccct65700

ccaccgccacctggtacgccgcgctcaacctgcaccacgtcatcgacgacgcgacctcgc65760

tgggcctgctgttccgcgaggtcgtcgcccatatgacgggccgcgcgggggagctggccc65820

cgcccgctccgtaccgcgacttcatcgcccacgtgcagcaccgcgcgcgcgagctcgacc65880

cggcggactacttccgggaccggctcggcgacgtcaccgagcccaccgtgatgttcgggc65940

tccaggacgtccacggcgacggccgcagcgtcctggacctgcgccgcccgctggccgccc66000

gcctcggcgagcggatccgggcctgcgcgaaggacctgcggatcagcccggccacgctct66060

tccacgcgggctgggccctggtcgtggcggcctgcgcgggccgcgacgacgtggtcttcg66120

gcaccgtcatgtcgggccgcctccagggcccgcgcggcatcgagcgcatgctcggcaact66180

tcatcaacaccctccccgtgcgcgtcgacctgaccggggtgagcgtgcgcgacctggtga66240

gcgccaccgaccggaccctgcgcgacctggtgcgccacgagcagaccccgctcgccgtcg66300

cccacggccacagcgccgtaccgccggagacgccgctgttcaacgcgatcctgaactacc66360

ggcacctggagtccgacgaccgcatcgacgacagcgagctggagcgcgcgggcgtcaagt66420

ccctcgcgggcgtcatcgagcgcagcaactaccccatcgccctgtccgtcgacgacctcg66480

ggcactccttctcgctcgacgcgcagatcgaccgggcccaggacgccgagctggtcatcg66540

gctacctggaaaccgccatggagcgcctcgtcgacgccctcaccaccgagggcgcggagc66600

ggcgcccggccctggacctgcccgtcctgagcgacgccgtacgccaccaggtgctcgccg66660

ggtggaacgaggcccccgccgccgagccggtgcagcggtgtctgcacacgtggttcgagc66720

ggaccgccgcctccaggccggacgcggtggcggtggagttcgaggaccgtcgtctgtcgt66780

acggggagctgaacgcgcgggcgaaccgtctcgcccggcatctgcgcggccttggcgtgg66840

gccctgacgtcctcgtcgccctgtgcctgccgcgcagcgaacacctcgtggtggccgtgc66900

tcgcggtgctcaaggcgggcggcgcgtacgtgcccgtggacccggcgtcccccgcggacc66960

ggatcgcgcacatcctgacggacagcgcaccccgcgtcctggtgacggacggcgcgctgc67020

ccgagggcctcgccgtccccgccatccccgtcgtggacgtgcgcgcggacgccgaccagt67080

gggcggcccgcgccgccgacgacctgtcggtgccggacctcacgccgtccgccatggcgt67140

acgtgatctacacctcgggctcgaccggagtgcccaagggtgtggtcgtcgaacaccgca67200

atgtggtgcggctgttcacgtccacggacgactggttccgcttcggcgagcgcgacgtgt67260

ggaccctgttccactccttcgcgttcgacttctcggtgtgggagatctggggtgcgctcc67320

tgcacggcggccgcctcgtggtcgtaccgcaggccgtcacgcgcagcccggaggacttct67380

accggctgctgtgcgagtcgggcgtgacggtcctcaaccagaccccgagcgccttccggc67440

agctgatcgcagcccagggcgaggaccccgagccgcacatggtgcgcgtggtcgtcttcg67500

gcggcgaggccctggaggtcgcctcgctcaagccgtggctgggccgcccggtcaacaaga67560

gcacccagctggtcaacatgtacggcatcaccgagaccaccgtgcacgtcacctaccacc67620

cgctcaccgaggccgacctcgaccggcccgtcagccccatcggccgccgcatcccggacc67680

tgcgcacctacgtcctggacccgcacggccgccccgcgcccatcggcgccgtgggagagc67740

tgtacgtcggcggcgagggcgtggcccgcggctatctgaaccggccggagctgtccgccg67800

agcggttcctggacgatccgttccgcgaggagccgggcgcgcgcatgtaccgctcgggcg67860

acctggcgcgctggctgcccgacggctccctggagtacctgggccgcaacgacgaccagg67920

tgaaggtccgcggcttccggatcgagctgggcgagatcgaggcccgcctcgccgaacacc67980

cggccgtccaggacgcccgcgtcctggtgcgcggctacgacgaccaggaccagcgcctcg68040

tcgcctacgtcgtcccgtcggcggagcacgcgccggccgtccgtgaactcctgcgcctgg68100

accgcaccgagccggaagcactcgagcggacctacgaactgcccaacggcatgacggtgt68160

tccagcagaacaggagcgagaccgacttcgtctacgacgagatcttcacgcacctcgaat68220

acctgcggaacggcatcaccatcgaggacggcgacaccatcctcgacgtgggcgccaaca68280

tcggcctgttcacgctgttcgcgggcagccgctgccccggcgcccggatccacgccttcg68340

agccgatcccaccggtcttcgactcgctgcgccgcaacgtcgcgctccacggcctcaacg68400

ccaaggtgcacgcctgcggcctcgccgccgaggcgaaggaggagaccttcaccttctacc68460

gccacaacacggtcatctcctccagcgtcaccaccgccgaacaggcccacgacctggtgc68520

gctcctacctgcgcaaccaggaggagctgaccgaggcgggcgcggccgacgccaccgccg68580

gggacgacctcgtcgacgcggtcgtcgacgcccgcctcgacagcgagcagttcacctgcc68640

ggctgcggaccgtctcggagatcatcgcggaggagtcgctcgaccggatcgacctgctga68700

aggtcgacgtggagaacgccgagtacgaggtcctcaagggcatccactggcgcgactggc68760

ccaagatccgccagctcgtcgtcgaactccacgacgtcgacggccagttggagaaggtcg68820

tcaccctcctcaaggccctcggctacgacgtcgtctgcgaacaggacaaccgcctgctgc68880

gcaacacgaccctctacaacgtctacgcccgccgcgccgaaggccaggacgcgcggcgcg68940

cggccgagcccgccaccccggccccgcgctggtccggccgggccgccctgctcgccgacg69000

tacgcgacaggctgggcgcggccctgcccgagtacatgatcccggcggcgcacgtcctca69060

tcgaagagctgcccctgacccagaacggcaagctcgaccagcgggccctgcccgcccccg69120

aggaccggcagcggcccgccgggcgccgcgtcgcgccccgcaccgaggccgagcggaccg69180

tcgcgggcgtctgggccgagctgctgcgcaccgacgccgacgccctggacgtcgacagcg69240

acttcttcgccctcggcggcaactcgctgctcgtcacccgcctcgtcaaccgcctcgccc69300

aggcgacgggcgccgaactcaccgtccagtccgtcttcgagggcccgacgctcgccgcga69360

tggccgccgagctggagcgccgcgcccccggggcgccccagggcgaggcgctcgacgtcg69420

ccgcgatcctggagggcatcgacttgatcgagaacatgagcgaagaagagctggacgcgt69480

tggaaggccggatcaagtgaccacgacgacgccgatgagcaccccgaacaacggcacctc69540

cctcgacctgatccggaagatcaagtcactgcccgccaacaagcagcgcgccctcatcgc69600

catgctgaagaagcagggcgtcgacctgtccgccctggaggcgatcggcccccgcccgca69660

caccggggacgagccggtccagctgtccttcgcccagcagcgcctgtggttcctcgcgca69720

gttggacggcaccagcgcgtactacaacatcccgatggccatgcgcctgagcggaccgct69780

cgaccggcccgccctgctgcgcgccctggagacgatcgtccagcgccacgaggcgctgcg69840

cacccgcttcgtcgagcgcgacggcgtgccgtaccaggagatcggcgacggccgcgactt69900

cacggtcggcgaggaggagctggccgaccccgcccagctgccgtcgatctgcgagcgcga69960

ggccgtggcgcccttcgacctggcccgcgactcgctgatccgcgtccgtctgctccgcga70020

gtccgagcacgcgcacgtcctgctcgtgaccatgcaccacagcgtctccgacggctggtc70080

gctcggcgtgttcttccgcgagatggtcaccctgtacgaggcgttccaggcgggcgaccc70140

ggcgccgctcgcgccgctgcccatccagtacgcggactacgcgcactggcagcgccagtg70200

gctcgtcgacgaggtgcaggaccgccagctcggctactggacgcgccagctcgacggcgt70260

cgacccgcgcctgcccctgcccgccgaccgcacccgcccggcgatcaagacctacgaggg70320

cgcgcacgagcgcttccacctgcccgaggagctgctgcggcagctgaaggccctcgccga70380

gcggcacgacgtcacgctctacatgacgctgctgtccgtctacgccctgctgctgcaccg70440

ctacagcgagcagactgacatcgccatcggcacccccgtcgcgaaccggcagcgcatcga70500

gtccgaggggctcatcggcttcttcgccaacaccctggtgatgcgcgccgacctgtcggg70560

cgacccggccttcaccgagctgctcggccgcgtcaaggacgtcgcgctacaggccttcag70620

ccaccaggacgtgcccttcgaagcagtcgtcgacgcgctgcagctggagcgcagcctcag70680

ccactcgccgctgttccaggtcgcgttcgtcctccaggaggcgcacaccgaccgcgaggt70740

gcgcctggggaacctcgacgtctccctcatcgagttcgacttcgacatcaccaagttcga70800

cgcgacgctcgacctgcgcgagacccccgacggtctgatcggcgccatcgagtacaacac70860

cggcctcttcgaccgcgacacggtccggcgcttcgtgcgccactacaccgcgctgctcca70920

cgccgtcgtcgccgcgccggacgagcggctctcccggctcagcaccctcgacgccgacga70980

gcgccgccaggtgctcaccgagtggaacgaggtgcccgcggcggcgcccgccgagcggtg71040

tctgcacacgtggttcgagcggaccgccgcctccaggccggacgcggtggcggtggagtt71100

cgaggaccgtcgtctgtcgtacggggagctgaacgcgcgggcgaaccgtctcgcacggca71160

tctgcgcggccttggcgtgggccctgacgttctcgtcgccctgtgcctgccgcgcagcga71220

acatctggtcgtggccgtcctcgccgtcctgaaggcgggcggcgcctatgtgccgttgga71280

ccccgcgtcccccgccgaccgcctcgcgcacgtgctcgacgacagcgccccccaggtgct71340

cgtgaccgacggaccgctgcccgagggcctcgccgtgccgtccgtcccggtcgtggacgt71400

acgcgcggacgccgaccagtgggccgccctgtcggccgccgacgtcaccggcacgggcgt71460

gggccccgcgcacgccgcctatgtcatctacacgtcgggctcgacgggcgtgcccaaggg71520

tgtggtcgtcgaacaccgcaatgtggtgcggctgttcacgtccacggacgactggttccg71580

cttcggtgagcgcgacgtgtggaccctgttccactccttcgcgttcgacttctcggtgtg71640

ggagatctggggtgcgctcctgcacggcggccgcctcgtggtcgtaccgcaggccgtcac71700

gcgcagcccggaggacttctaccggctgctgtgcgagtcgggcgtgacggtcctcaacca71760

gaccccgagcgccttccggcagctgatcgcagcgcagggcgaggacgcgcggccgcacgc71820

cctgcgagccgtggtcttcggcggcgaggccctggaggtcgcctcgctcaagccgtggct71880

gcgccgcccggtgaaccagggcacccagctggtgaacatgtacggcatcaccgagaccac71940

cgtgcacgtcacctaccggctgatcaccgaggccgacgcggaccgcaccgtgagccccat72000

cggcgagcgcatccccgacctgtgcacctacgtcctcgacggacacggccagccggtacc72060

ggtgggcgtcgtcggggagttgtatgtgggcggcgcgggtgtggcccgcggctacttgaa72120

ccggccggagctgtccgccgagcggttcctggacgatccgttccgcgaggagccgggcgc72180

gcgcatgtaccgctcgggcgacctggcgcgctggctgcccgacggctccctggagtacct72240

gggccgcaacgacgaccaggtgaagatccgcggcttccggatcgagctgggcgagatcga72300

ggcccgcctcgccgagcaccccgccgtccaggacgcccgcgtcatcgcccgcgaggaccc72360

ccccggcgaccggcaactcgtcgcctacaccgtcctgcgccccggcgccgacgaggccga72420

ccaccgcgccgacctcgcccgccacctgcgcaggaccctgcccgactacatggtccccgg72480

cgccttcgtggccctggaccgcctgcccatcaccggcaacggcaagctcgaccgcaaggc72540

cctgcccgcacccggcatcgaggccttcgcgcagcgcgcctacacggcgcccaccaccgc72600

caccgagcggacgctcgccgccgcctgggccgaactcctcggcttcgacgaggaccgcat72660

cagcgcgcacgacaacttcttcgcgctcggcggtcactccctgctcatcaccgtcctcat72720

cgcccgcctcaaggagcgcggcctggacgtcgccgtgcgcagcgtcttcagcagccccac72780

gctcgccgacctcgccgccgacatcgaccgcgcgggaccggccgccaccggctacgccgt72840

gcccgcaccggcggtcccggagggctgcgagcggctcacccccgagatgctgccgctggt72900

ccgccttgaccaggccgccgtcgacgccgtcgccgcccgcgtgcccggcggcgccgccaa72960

cgtgcaggacgtctacccgctcgtgccgtcgcaggagggcatcctcttccatcacctgat73020

ggaccccgccaacgacccgtacgtcatccccatcctgctcaccgcccccgaccggcggac73080

gtgcgacgccttcgtggacgccctgcaggccgtggtggaccggcacgacgtgatgcgcac73140

ggccgtcgtcaccgaaggcctcggcgagcccgtacaggtggtcctgcgggacgtccgcct73200

cgacgtggagcggcgcaccctcgacgccgccgactccgacgccgcggcggagcaggcccg73260

cgcctggctcgcggacccggggacgatcacgctcgaccgggcaccgctgctgcggctcgc73320

cgtcgccgccgacccgcactccgcacggcacttcctgctcctgcgcgtccaccacctcat73380

cgaggacgcgacctcgctgcgcatcatcctcgaagagctcgccgcccacatggcgggccg73440

cgccgacgaactgcccccggccccggcctaccgcgacttcgtcggccacaccctgcacca73500

gctcgccgcgaacgacgccgaggcgtacttccgccgcgagctgggcgacgtcaccgagcc73560

caccacgccgttccagctcgtcgacgtgcacggcgacggcagccgcgtgcgcgacctgcg73620

ccgctccctgccgcccggcctcaccagccgcctgcgcgagcaggcccagcggctgcggat73680

cagccccgccgcgctcttccacgccgcctgggccctggtcaccgcggccaccggcgggcg73740

cgacgacgtggtgttcggcaccgtcctgtccggccgcctccagggcgtgcccggcgtcga73800

gcggatgctcggcaacttcatcaacaccctgcccctgcgggtccgcctcgccgaccgcag73860

cgtcaaggacctggtgtccgccgtggacgcctccctcaaggaactcatctcgtacgagca73920

gagcgccctgaccctggcccagcgctccagcggcctggacggcgacgccaccctgttcag73980

ctcgatgatcaacttccggtacttcgagccgcgccagggcgacctgggcccggccaccct74040

ggaggacctgggcatccgctggctgggctccctggaccgcaccaactacccggtgggcgt74100

gtccgtcgacgacaccggcaccgaactgtccctgaacgcccaggtcgacgccaccctctc74160

gccggacgccgtcctcggctacgtcgaggcggcggtgtccggcctcgtggacgcgctcgc74220

cgccgacgacggcgccggcacccgggcgctcgacatcgacgtgctcccggccgcggaacg74280

cggccgcctgctgaccgagtggaacgacacggacaagccctacccggacgaccactgcct74340

cttcgaactcttcgaggagcacgtccggctgcgccccgacgccgtcgccgtcgagcacgg74400

cgagcagcggctgacctacgccgagaccaacgcccgcgccaaccgcgtcgcgcactggct74460

gcgcgagcagggcgtcggccccgacaccctggtcggcctgtgcgcccgccgctccccgga74520

gctcgtgaccggcctgctcggcatcctcaaggccggcggcgcgtacgtccccatcgaccc74580

ggactacccccaggagcgcatccgcaccctggtggccaactccggcgtcggcatcgtgct74640

cagccagtcccacctgccgtccgagccgctcgaaggcgcggacgggggtaagggacccct74700

ggtcgtccacctggacaccggcgaacgcgccggggacggcacgcagctgctcgccggccg74760

ccccgagcacgacctgacgcgcgccgaactcggcctcacgcccgagcacctggcctacgc74820

catcttcacctcgggctccaccggcgtccccaagggcgtcctcgtggaacagcgcggcgt74880

cgtccgcctggtgcgcaacccggactacttcccgacggaccccgacaccgtcgtgctgca74940

ccactcctcgatctcgttcgacgtcggctcccaggaggtcctcggcccgctgctgtgcgg75000

cggacggctcgtcctgcacgacggcgactccaaggacgtgggcgccctcctggaccgcgc75060

cgagcgctccggcgtcacgatgatggccctgtccgcggccttcctgcccgcgttcgccga75120

ggccgcgcaggggcggcggctgccgctgacgtacctgggcgtcggcggagaggccttctc75180

cgccaaggacgtgcgccgcctgtacgcggcccaccccggcctgaccgtcgtcaacgccta75240

cgggccgaccgagaacagcatcgcctccacctgccacgtgatcccccgggacatcgccga75300

ggacgcggtcatccccatcggcaggcccatcgcgcagtccaccgcgcacgtgctcgacgc75360

gcatctgcggcccgtgccgctcggcgtcgtcggcgagctgtgcgtgggcggcgcgggcgt75420

cggccgcggctacctcggcaaccccgagctgacgaaggagcggttcgtcgccgacccctt75480

cgccgcgcggcccggggcccgcctgtaccgcaccggcgacctggtgcgccgactgcccga75540

cggcaccctggagttcgtcggccgcgtcgacgaccaggtgaaggtccgcggcttccgcgt75600

cgaactcggcgagatcgagaacgcgctgcactcccacccggccgtgcgcggcgccgtcgt75660

caccacccgggccagcggcgagacgaagaagctcgtcgcctacgtacggcccacgaccga75720

ctggctggacacggccgcgcgcgagcagaacgccgaccgcctggagcagtggcaggacct75780

cttcgaggaccagtacggcaccgacgcggacgagcaggcgaacgccaccggcaccgggac75840

cggcaccggcaccagttccggctccggggactccggggactccggggacgacctcaacct75900

ggtcggctggaactgcagctacaccggcgacgccatccccgagcacgagatgcgcgagtg75960

gatcgacggcaccgtccagcggatcgaggagctgcggccccgcaggctcctggaggtcgg76020

ctgcggcacgggtctgctgctgttccgctacgccggagcctgcgaggccgtgcacgccgt76080

cgacatctctgcctcggccctggccggagtgcggcgcggcgccgaccgccgcggctggtc76140

gcacgtcaccctcgcccagggcgacgcccggtccgtgacgctgcccgaaggcaccgacgg76200

cacggagaagttcgacaccgtcgtcatcaactccgtggcccagtacttcccgaaccggct76260

ctacctggaagaggtcatcgagcggctgctgccgctcgtcgccgacggcggccggatcct76320

cgtcggcgacgtcaggaacctcgacctgttctccgcgcacgtcacggccgtcgagcgcag76380

ccgcctgtccgcgcgcaccgccgtcgccgccctggcccgccaggtgcagcgccgccgcca76440

gcaggagaccgaactcctcgtcagcccgagctacttcgccgggctgccccggcggttcgc76500

ggacatcggctccgtcgacatcgccgtcaagcgcggcaccggcggcaacgaaatgctcag76560

ctaccgctacgacgtcgtcctcaccaagggcccggccgccgacgaggacgacctgccgtg76620

gctgaccgccaccacgcccgacgagctgcgcgccctgctcgccgacggcggccgcccgcg76680

gttcggcgtcacgggcctggacaacccgcgcgtcgccgacgacgtccgggccgccgcgag76740

cctgcgcggcaccaccggacagcagcacgtcgagccgctcggcgcgagccgcctcacgga76800

cgccgcggtccagcgggtgcgcgacctggaggacgtcctcacgtacgccgagaagctcgg76860

ctaccaggtcgccgcgacctggtcccaggaccgcctcgacggcctggacctggtcctcgc76920

caaggggacgcggccgaccgcccgcgcccgggccgcgtacggcgcgacccacctggcgaa76980

cgtgccgcagatcgccaccaccgggcaggccctgacccgcaccctgaaggaccacctggc77040

gggcaggatccccgagtacatggtccccagcgtcttcgtcgccctcgaagagctgccgct77100

cacccccaacggcaaggtcgacaagcggtccctgcccgcgcccgacgaggccgacgtgca77160

caaggaggtctacgtcgcgccgcgcaccgccaccgagcgcgtgctgtgccgcctcgtcca77220

ggacgtcctcgacctcgaccgcgtcgggctccaggacggcttcttcgacctcggcgggca77280

ctccctgctcgccacccggctcaccatccgcgtcaagcaggagaccggcaaggagcttcc77340

gctccagtcgatcctcgccggcgcgaccctcggcgaactggccgccgcactcgacgcggc77400

ggacggcggcacgtccgacggggccgtcccgctggtgcccgtcaccgggcccggcgagga77460

gagcccgctctcctgccagcagagcgagctgtggttcctcaaccagcgcgcgcacctcgg77520

ctcgtcgtacgacaacgtgcagatggcctaccgcgtcatcggcccgctcgaccggcaggc77580

atacgcccgcgccttcgaagggctcgtggcccggcacgccgtgctgcgcaccagctacct77640

gcggcgcggcgacacctacgtccagaaggtgaacgacaccaccggcttcgccgtcgcctt77700

cgaggacgtcacgggtgacagcgcggtcaccgagttcctccgcgccgaacggccgcgacc77760

gttcgaccccgcggaccggcacatgctgcgcgtgcacatcctgaccctcacgccgtacga77820

gcacgtcgccgtggtgacccggccctggggcatcttcgacggctggtcgaccggcgtgtt77880

catcgccgagctcaacgccctctaccaggcgctgagccgcggcgacgagccgtcccttcc77940

cgaactgcccgtccagtacgcggacttcgcgcactggcagcgccgcaccttcgacgccga78000

cgcccgcgcgcggcagcaggcctactggcgcgcccagctcgccgacctgccgtcgtgcac78060

cgcgctgcgcaccgactaccggcggcccgaggcgaagtcgtaccagggctcctcggtcga78120

ggtgaacgtccccgccgcggtgctcgaccagctcaagcgggtcagcaaggagcgcggcgg78180

cacgctctacatgacgctcctttcggccttcgcgacgctgctcggcgcccacaccgacga78240

ccgggagctcgccatcggctcgccggtgaccaaccggccgcggccggagctcgaacgcct78300

cgtcggctacttcatcaacgtcctggtcatgcgtctggacgtgcggcccgagcaggcctt78360

cgacgacctcctcgcgcaggcgcagcgggtcaccgcggccgcccacgagcacaaggaggt78420

cccgttcgccgatctcgtgcgggacctggtgcccgagccggacccggcgtattcgccgct78480

gttccaggtgatgttcaacctggtgcccgccgtcgaggccgcgccgcccggcgccgcgga78540

ccccggcgcgctcggcttcgtgcccctgcccaccgacagcggcacggcgaagttcgacct78600

caacctcgtcgtccgcgagacccccgacggcctgcgcggctacctggagtacagcaccga78660

cctctacgccaggagcacggtccggtccatggcggcgacctatgagaggttgctgctcaa78720

gatcgtcacgcagcccggcgcgagcctcgcacggctgcgcgaggcggcggcggacggcgg78780

tgccggatgagcaccacccacgccgcggccgaccccgaccaccccacccgtcccacccca78840

cccagcgaaagcgcacacatgaccaaggaaaagaccttcaccctgatcgtcgacgccgtc78900

cgcgagatcctcccggaactcgcagaccacgacttcgccgagaccgacaccctggacgcg78960

ctgggcgccaactccatggaccgcgcggagatcgtgatgaccgtcctggaggagatggac79020

ctggacatccccctggtcgacacccacgggccgcagaacctgggcgagctcgcgcggcac79080

ctcagcgacacggcagcggtcaaggccgggtgacgtgagcgactccgcagggctcgtcgt79140

caccggtctcggcgtcaccaccgccgtgggccggggcaaggccgacttcacccgggcact79200

gttcgcgggagagcaccgcttcgccgtcatggaccggccggggcggcagtccggcacccg79260

cttcgtgggcgccgagctgcccgccccgccgccacctgcccggctcggcgcccgtgagct79320

gcgcaccgcgtccctcaccggacaggtcgccctcgccaccctcgaagaggcgtggaccga79380

ggcgggcctcgacggctacgacccggaccgggtcgggctcgtcatcggcggcagcaacct79440

ccagcagcgcgaactcgtccgggcccaggaccggcaccgggccaagccgcacttcctgcg79500

gcccagctacggcctgtcgttcctggacaccgacctgtgcggcctgtgcacgagcgcctt79560

cgggatccgcggcttcgcgcacaccgtgggcggcgcgtcggccagcgggcagctcgcggt79620

catcgaggcggccgaggccgtggcctcgggccgcgtcgacgtgtgcgtcgccctgggcgc79680

gctcgccgacctgtcgtactgggagctgctcggcctgcacgcgatgggcgccatggcggg79740

cgaggaccacgccgacgcgcccgccgaggcctgccgtcccttcgacaaggcacggtccgg79800

cttcgtctacggcgaggcctgcgccgccctggtcatcgagcgcgggggcgcccgcccgga79860

cgcccccgccccctacgcgcggctcagcggctggtccgtgcgcctggacggcaaccgcaa79920

ccccaacccgtccctggcgggcgagaccgacgcgatccgccaggccctggaccgcgccgg79980

gctgagcgcccgggacatcgactacgtcaacccgcacggcaccgcgtccccgacgggcga80040

cgagaccgaagtggccgcgctcaaggcctgcggcctcacccacgcggccgtcaacgccac80100

caagtcgatcaccggccacggtctgacggccgccggagccgtcgaggcggccgcatccct80160

gctgcagatgcggcacgggcggctgcacccgacacgcaacctcaccgcgccggtcgacga80220

cgccccgcgctgggtgcgcgaggcggccgtcgaggccgacatccagcactgcctgagcct80280

gagcatgggcttcggcggcatcaacaccgcactgtgcctgagcgcgtgcgccgcatagag80340

agcagaacagcgaaccccatgtcccgcgtcggtatcgaagcgatgaacgtgttcggcggc80400

tcggccgtgctcgacgtcatgcagttggcgcggcaccgcgagctcgacctcgcgcgcctg80460

aacaacctcctgatgaaggagaagacggtcgcgctgcccttcgaggacccggtcaccttc80520

ggggccaacgcggcccggccgctcctcgaccgcatgagcgaggaggagaagggccgcatc80580

gaactcctcatcacctgcaccgagtcgggcttcgacttctccaagtcggcgagcacctac80640

ctccacgaccagctgggcctgagccgcaactgccgtatgttcgagctcaagcaggcctgc80700

tacgcgggcaccgcggggctccagatggcctgcaacttcatcctctcgggcacctcgccc80760

ggcgccaaggccctggtgatcgccaccgacatctcgcgctacatcctggaggacggcgac80820

gacgtggccgcgcaggactgggcctacgccgagcccagcggcggcgcgggcgcggtggcc80880

ctgctgatcagcgccgagccgcacgtcttccagctcgacgtcggcgccagcggcacgtac80940

ggctacgaggtgatggacacctgccgccccgccccggacagcgaggcgggcgacgtcgac81000

ctgtccctgatgtcgtacctggactgctgcgagcaggcctaccgcgcctacgaggccaag81060

gtggagggcgcggactaccgcgacaccttccagtacctcgccttccacacccccttcggc81120

ggcatggtcaagggcgcccaccgcaccatgatgcgcaaggtcgccaaggccaagggcgcc81180

gagatcgccgaggacttcgagcgccgcgtcgcgccagggctcggctactgcggccgcgtc81240

ggcaacatcatgggcgcgacggtcttcctctccctcgccggcaccatctgcaacggcgac81300

tactcagacccgcggcgcatcggactgttctcgtacggatccggctgctgctcggagttc81360

tacagcggcgtcgtcaccccggacggcgcggagcggctgcgggccatgggcatcgaggac81420

cacctcgacgcgcgctaccagctctccctggacgagtacgaccagctgcttcgggagagc81480

gcgttcgtccgcgtcggcacccgcgacaccgtcgtgaaccaggacttcgtcgccaggacc81540

gccccggccgcccggaccgcgcagggcgccgggggcggctcgccgcgcctcgtcctgcgc81600

gcgatcaaggagttccaccgggagtacgcatggatcgactgacccgctccgcctactcca81660

ccctgcgcgtccgcgaacagggcagcgtgctcttcgcgcagatccaccggcccgaggcgg81720

gcaacgccatcaacgccacgctcgtccacgagctcgacgacgtcttcgcgcgcgccgccc81780

gcgcggagcacaccaccgtcgtcgtcctcgaaggactgcccgaggtgttctgcttcggcg81840

ccgacttcggcgtgatcagcgacgcggcgcgcacgggccaggacacgtccttcgaccccg81900

agccgatgttcgagctgttccggcgcatggcctacgccgacgtgctcaccgtcgcgcacg81960

tgcgcggcaaggccaacgcgggcggcgtcgggctcgtggccgcgtgcgacgtggtgatcg82020

ccgacgacagcgccaccttcagcctctccgagctgctcttcggcctgatcccggccgtcg82080

tgctgcccttcctgatccgcaggaccggcttccagcgcgcccactacctcgccgccacca82140

cccagaccgtcgacgcccggcaggcccacgagtgggggctcgtcgacgcgctcggcaccc82200

ccagcgaggcgctcctcaagcgccacctccagcgcctgggacggctctcgaagaagggcg82260

tcacgcgctacaaggcgtacctgcgcgagctgtccccgctcaccgagcacaccaaggacg82320

tcgcgctcgccaccaaccgccaggtcttcggcgaccccgacaacgtgcgggccatccggc82380

gctacgccgaagagggcgtcttcccctgggagaccgcgacgccggacgccaccgcgacgc82440

cgaacccgtccccgcagccttccccgccgcagtccccgcagccgtccccgagcgagacca82500

ccgtggaaccacagcaccagcgggccaccgccccgccgcccgccctctcgccccgcgccc82560

tcggcagcccgcgcttccgcgcggcgcacggcgtcgactacgcctacgcggccggggcga82620

tgtacaagggcatcgcctccgtcgacctggtcaccgcgctcggcaacgcgggcatgctcg82680

gcttcttcggcaccggcgggctcgccctcgacgaggtcgaggacgcgatcatccgcatca82740

agaagggcctcgaccccggccgcgccttcggcatgaacctcctgaacaacccggacgacc82800

ccggccaggaggcccgcaccgtcgagctctacctgcgccacggcgtgcgctccgtcgagg82860

cgtccgcctatctgcggcccacccccgcgctggtccactaccgcctcgcgggcctcggca82920

ccgacgccgaaggacgcctccgccaggaccaccacatcatcgccaaggtgtcgcgcaccg82980

aggtcgccgagcacttcctgcgcccggccccggccccgctggtccgccggctcctcgacg83040

acggactcatcacccccgagcaggccgaactcggcgcccgcctcccgctggcgcaggacc83100

tgtgcgtcgaggcggactccgcgggccacaccgacggcggcaacgcctacgtcctgatgc83160

ccgccatgcgcgccctgcgcgaccgcgtgacgcgcgagcagggctactccgaagagggcg83220

gcgaggccgccgtgcgcatcggcgccgcgggcggcatcggcacccccgaagcggccctcg83280

cggccctgaccctgggcgccgacttcctcgtcaccggctccatcaaccagtgcaccgtgg83340

aggccgggaccagcgacgcggtcaaggacctcctccaggacctcggcgtgcacgacaccg83400

agtacgcgcccgcgggcgacatgttcgaggtcggcgcccgcgtccaggcggtcaggaaga83460

gcacgttcttccccgcccgcgcccagaagctgtacgacctctacgtacggcacgactccc83520

tcgacgacctcgacccgcgcacccgggcgaccctggagaacaagtacttcaagcgctccc83580

tcgacgaggtgtgggaggagacccgcgcccacctggcacggcgccaccccgcccggctcg83640

ccgaggtcgagcgcagccccaagcagaagatggcccacgtcttccgctggtacttcgtgc83700

actccacgcgcctggcgctgcgcggcgccgaccagcgcgtcgactaccagatccactgcg83760

gacccgccctcggcgcgttcaacacctgggtgcgcggcaccgacctggagccctggcgcg83820

gccgcagggtcgacgtcatcgccgaacggctgctccgggagaccgcggccctgctcaccg83880

agcgcctggccgcctacgccgccctggccgccgacagcacaccgccctcctccgacccca83940

cccccgacaccgcccccggcggaccggcacctctcgcgacggctgagtgatcacatgact84000

tccgtgtacgtattccccgggcagggctcccagcgcaagggcatgggcaaggacctgttc84060

gagaagtaccccgacctcgtggcccgcgcggaccggctgctcggctactcgctgcgcgac84120

ctgtgcgtcgacgaccccgaccgggtcctcaaccgcaccgagtacacccagcccgcgctc84180

tacgcggtcagcgccctgcagtacctcgaccacatcgactccggcggcgccccgcccgcc84240

gtcgtcgccgggcacagtctgggggagtacagcgccctgttcgccgcgggcgccttcgac84300

ttcgtcaccgggctcgacctcgtgcgcaggcgcggcgagctgatgagccgcgcccccaag84360

ggcgcgatggccgccgtggtcaacctcgaccaagagcgcgtcgcggagatcctggccgcg84420

ctgccgcactccggcatcgacatcgccaacatcaactcccggcagcagtgcatcctctcc84480

ggcacctacgacgaggtccacgccccggacgtccgcgaggcctacaccgcggcgggagcc84540

aggttcatcccgctcaacgtgagcgcggccttccactcgcgctgcatgaccgaggtccag84600

gaggagttcgcgcgccatctgccgggcgtcgcgttccgcccgctgcggatccccgtgatc84660

gccaactgcacggcccggccgtacccgacgaccggctactccgacctgctggtgcggcag84720

atatcgagccccgtgcggtggtacgagtccctctccctgctccttgcgcgcggccacgac84780

gagttccgcgagatcggccccggcgacgtactcaccaagctcaccgccaagatccgcgag84840

gagccgctggccgtcgaggaaccgccggccgccgaggcgcccgccgcgccccaggcgccc84900

ccggcccccgccgcgccccgcccggccccgcaccggaccctgcggcgccccgaggtcgtc84960

ttcatgtacggcggccagggcacgcagtactaccgcatggggcaggagctgtacgacacc85020

cacccggcgttccgggacgccatggaccggtgcagcgcgctgtacgaggcggcacagggc85080

acctccctcgtcgccgcgatgcacgacagcacccggcgcggccaggacttcgacgacgtc85140

ctgcacacgcacgcggcgctctacagcgtcggctggagcctcaccgaggccctgcgcgcg85200

gagggcttccaccccgacgcggtcctcggccacagcctcggcgagtacgtcgcggccacc85260

gtcgccggggcgatgtccttcgaggacggcctcgacctcgtgatgaagcaggcccacctc85320

ctcgacctgcgctgccgccccggcggcatgctgagcgtcctcgccccgccctcgctctac85380

cagcggcggcgcgacctgttcgccggactcgccctggcgggcgtcaacttcaccggcgac85440

accaccggcaacttcgtcgtcagcggcgaggccgagcgcgtcaccgaggcccgcgccgcg85500

ctcgaccgggaaggggtgatcgccgtccgcctcccggtgcgccacggcttccactccggc85560

ctcctcgacgacatccggcaggagtgccggagcctgggacgcgcggtcgcggtgaactcg85620

cccaccctgccggtgtattcgtgcgcgtacgcggcagagctggacggcgcggcgctgacc85680

ggctgggacgactacgcgtgggacgtcgtccggggccgcgtgcgcttcgacgagctgatg85740

gccaccgcgttccgcgacccggcgcgccactacttcgtcgacctgagcgccagcggctcc85800

ttcgtcaacttcctcaagcacggctacggccccgactaccggggcgcgttcgcgatcaac85860

cagttcggcaacaacacggcgtcgatgcgccgtctgcgcgagggcctggagcaggccgtc85920

cagcccgccctcgtctgaccccgggaacggcaaagggggctcaccgccgcggcggtgagc85980

cccctgacgccttctcaggcgggcactcggatcaggccggtcagccgaccgacaccggca86040

gcgaggccacgccgcgcacgttgatgcggccgttccaggtcacgtcgcccgcgagggaca86100

ggtccgggaaccgcttcagcatccgctcgaaggtgacgctcgcctccaggcgcgccaggg86160

ccgcacccaggcagtggtgcgagccggagccgaacgccaggtgggcgcgcgcgccttcgc86220

ggtcgaggcgcagcgtgtccgcgtcctcgccccagcgcgcggggtcgcggttcgcggagg86280

cgagggcggcgaccaccatcgagcccggggggatctcgacgccgctgagcacggtcggtt86340

cgagggtgatgcggcggctcgactgcaacgggctgtcgtagcgcagcagttcgtcgacgg86400

cgttgggcatcaggtccgcgtccgcgcgcagcgcggcgagctgctcggggtggcgaagca86460

gcgcgtgggtgccgttggcgagcaggttcacggtcgtctcgtggcccgcgatgtacagca86520

gctggatctgcgcgaccagctcgtcgtcgctgagcttgtcgccgtcctcctcggcctcga86580

tgagggccgtcatgaggtcgtcggcggggttgcgccgcttccaggcgatcatctcggaag86640

tgaggacggccagttcggcgtccgcgttctcgatctcctgcatgacggccgggtcggcga86700

cgggctcaagggagcggacgatcgtgccgctcagctcctggatccgctcgtggtcggtgg86760

gcggggcgcccagcatctccgcgatcaccgtgaacggcagcggcgacgcgagcgcgggca86820

ccaggtccgcgccgcccgccgcggcgatcttgtcgagcatgccgtcgacgagctcgccga86880

tgcgcggcgcgagcgcctggatcgacttcggcgtgaacgccttctgcaccaggcggcgca86940

gccgggtgtggtccggggcgtcccggtcgatcatcgagaagccgtcgatgagcggagtct87000

tgcgcgactcgtccttctgccgcaggttctccagcgcgccggagttcacgttgcgcagtt87060

cgaccgacgcgcccgagcgcagcagcccgaacacgtcctcgtaccgggtgaccacccaga87120

accccagggggtgcggatagaccggggcgacttcgcggagcgtcgcgtactgcgggtacg87180

gattgtcggtgaacccctcggcgaaggggttgaacagcggtatctgctgttcctgaggga87240

gagcgcccccggtcatctcgtgctccttgtggtggcaccggctggagggaccccccgacg87300

gtggtccatgcggatccaccgcctcggccctcggccccggctggatgagagttcgcaggt87360

cacagtagtgacgccgggaggaccggtgacacgtgaccaggatgagagcaggagagtacc87420

cggcgtagccgggccgacactaggccgtccagtgggaggggcgctccagcgggtggggga87480

ccttcgtccgggcgtcgccccgcgcggcgttcagctggggctgggtgaggaacagcgcgc87540

cgcgcagatccgcgccgcacaggttcgtgtcccgcatgtccgcgccgatcaggtcggcgt87600

cgcgcaggtcggcgtccgacaggtcggccgcgatgagcagggcgccgcgcatgctggcgc87660

cgcgcagcttcgcgccgcgcagccgggagcccatgaggttggcgccgcggtggttcttct87720

tgcggcccgggaccgccgcccgggccagttcgctggcgcggagcagcagcgggttcacct87780

caccgcgcagcgcgtccacgtcgacggcgagcagcgtctcgaccgtgtcccgggtgagcg87840

cgtcgatccgctcgtacgcgccgcgcagctcccggtggacgggccgggccgcggacaggt87900

ccagggcctgcgcggtgtacttcaggagctcctggagctgtcgtacgacggggaagacct87960

cgtacatcgcgcgggccgagtccggctcctcgcgccagctgacgcccttgaacgtgacct88020

gggagaccttctggcccgcgccgaagcagtcgaagaccgtacagccgttgtagcccttgt88080

cgcgcagccgctcgtggatcccgcagcggaagtcctcctggaggcttccgcacggcgtgc88140

cggcggacttgttcaccgggaagtccgacgagcgcgagaagggcagcgccacgcagcaca88200

gaccgaagcagctcccgcagtcggcctgcaggtcgggctgggcggcgtgcgaggtgcgct88260

cggacaagacggtggctcctgaggggcgtgcggcggcgtgcggtggtcgtacgcctccat88320

tgtccctcgtacgtcgaccgcgacggtacgagggcccaagggggcgcactcgggacggga88380

gggccggtcaggtcacggacgggggcgcggggcgccccggtcccgtgctcaggcctgcgc88440

ggccttcgccgccttctcggcctgctccgccttcttcgccttgaggcggaccgtctcctt88500

gcggacctcggcctgcgtggcgcgctcgcgctccagccactcggggcgctcttccttcag88560

cgcgtcgatctgctgcgtggtgaggggctccgtgacgccgccgcgggcgaggcccgacac88620

ggagacgcccagcttcgcggcgacgaccgggcgggggtgcgggccgttctggcgcaggtc88680

gcgcagccactggggcgggtcggcctgcagggcgttgagctcggtccgcgagacgacacc88740

ctcctggaactcggcgggggtggcctcgaggtacacacccagcttcttcgccgcggtggc88800

gggcttcatggtctgggtggagtggtgcgacgtcataggaccagggtatcgagcgaatgc88860

gcgaccgctgaccacggcgggcccgtcgccgcccgcaccctccggcgggtcggccgccga88920

ctacgggcggtagtctggcgaggtgacaggctcggaagactctcccgcgttccggctcgc88980

ctacgtgccaggcgtgacgccctcgaagtgggtgcgcatctggaacgagcggctgcccga89040

cgtccccctgaccctcgcccaggtgcccgccaccgaggtctgcgaggtcctgcggaaggg89100

cgatgccgacgcgggattcgtacggcttccggtcgacggggaggacctcagcgcgatccc89160

tctctacgaggagacgacggtggtcgtggtccccaaggaccacctcttcgcggcggccga89220

cgaggtggccgtggcggacctcgccgacgagctggtgctgcaccccctggacgaccccct89280

ggagtgggagcgtccgccgggccgccccgccctcgagcgccccgccacgaccgccgacgc89340

cgtcgagctggtggcggcgggcatcggcctgctgatcgtcccccagtccctggcgcggct89400

gcaccaccgcaaggacctcacgtaccgcacgatcacggacgtccccacgtcccgcgtggc89460

gctctcgtggccccaggaggccacgaccgacctggtggacgacttcatcggcatcgtccg89520

cggccgcaccgtcaacagcacccggggccgccgcgccgagcccgagccgaaggccaagcg89580

cccggagaagggcggcgcccgacggcagcagcccgccgggggcaagggcggcggccgggg89640

caccggcaagacggcgggcaagccgtccgccaagaacgcgcgccggggctccggcggccc89700

gaagggcgtcaagggcggcaagccgcgccgcaggccgtagcgtcccgcggtcccgctccg89760

cgcgtcaccagggctggttcggcaggaacgcgccggagcgcgccgactccgcctcccgcg89820

cccggtgggagtggaccagggcccagcagcccaccgccgccaccccgatggcgaggacga89880

ccaggtgccaggtggagaccgtggcctggatcgagctgccctccgggtgcgcggcgacgg89940

tgatcccgagggccagcggtacggccatcgcgagggcccagccgccgagcacggacgagg90000

cgaggcggtgcggaagcacgagacccgcccagagcagcacggcgagggtgccaaggacgg90060

ccaccgcgcagctcatgagcccgggaacggcgattcccgcggccgtggcgcccgtggcgg90120

cgcccgccgccgcccggatcagccggcggcggtcgagggaacgggcccgcctcccgccgt90180

gccgcgccagatgcacgacggcgagcagtccgacggctcccgcaagcaggtagggcccgc90240

tgttgagccatgcgtcctggtcgagttcgcgctggctctgttggaagctgttgatgacga90300

atccgctggtcagggcgaggacgccactgccggccaggagtccggcccaggtgcgcctgc90360

tcggtgagacaagactcgcccaggagccgatgagcagccccaggaaggggaggtgggcga90420

ggaccaggagggcgttgagcaccccgtccgccccgaaggggtaaccggccgcgacggtgg90480

cccagggggcgtcgggtcccgaggcgtcggcggtgtgccccgcgtcgatccaccacgtct90540

cgaaggggcgcgcacggaagacgaggagtcccggcccggtgagcacggcgtgccagttga90600

gctggaaccaggacaggacccagaggccgaccgtgccgaggccgaggagccccggcagga90660

cggggttcacgagggacgcgggccgcgcggcctgccgccacggcagcgtgggcggcggca90720

cagcaggcgcgggcggcgggcgccgcggtgccaccggggccgcggccatcatggtggtga90780

cgcggccctccgcgatctgccgcagctccgcggcggcctgcgcgacgtgcggccgttcct90840

ccgggttcttggccagcagggcgtacagcacggcccccagggcgggcccggcgcggcgcg90900

acacgggcggcgggtcggagagcaccgccgcgatggactccacagcggcgggccgggcga90960

agggcgacgcgccctccagggcgtggaagagcgtgacgccgagggcccagaggtccgtgg91020

cgggcacgggcgccccgcggatctgctcgggcgccatgtaggccggggtgccgaagacgc91080

tcgtcgtgctggtgacctcgctggagagccgggcgatcccgaagtcggccagcttgaccc91140

ggccgcccgcgaggagcatcacgttctcgggcttgacgtcgcggtggatcacgcccatcg91200

cgtgggcggcgccgaggacctcggcgagctgcgcgccgatcgacgccacccgggccggcg91260

gcagggggccctcccgggccacgagcgcggccagggtggtgccccggacgagctccatga91320

cgatgacgacctcggagcccgcgcgcaccacgtcgtagacggtgacggccccggggtggt91380

tgagcttcgcggccgcgcgggcctcccgcagcaggcgcgcggtggccttggtgtccaggg91440

gcgccgccccctgcccgggaccgcgcacgtgtttcacggcgacctcgcgcccgagcaggg91500

tgtcgacggcccgccacaccacacccatgccaccccgtcccagctcctcgatcagctgga91560

acctgccaccgaatggctgcccgccctcaaccat91594

<210>2

<211>41

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>2

tcaaggcgaatacttcatatggcgcggctgatcggccgacg41

<210>3

<211>30

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>3

gtgcgggcccccgccgaaaggcccacgcgc30

<210>4

<211>30

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>4

ctttcggcgggggcccgcaccccagaggca30

<210>5

<211>41

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>5

gacctgcaggcatgcaagctttctcctcgtccgacgtcgtc41

<210>6

<211>21

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>6

tcgtcatcggtacggaagagg21

<210>7

<211>21

<212>dna

<213>链霉菌(streptomycesspectabiliscctccm2017417)

<400>7

gcggagttctggttcgagatg21

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  • 技术研发人员：孙宇辉;罗明和;邓子新
  • 技术所有人：武汉大学
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  • 1、薛老师：1.CRISPR-Cas系统 2.基因编辑 3.基因修复 4.天然产物合成 5.单分子技术开发与应用
  • 2、张老师：1.探索新型氧化还原酶结构-功能关系，电催化反应机制 2.酶电催化导向的酶分子改造 3.纳米材料、生物功能多肽对酶-电极体系的影响4. 生物电化学传感和生物电合成体系的设计与应用。
  • 3、豆老师：1.环境纳米材料及挥发性有机化合物（VOCs） 2.CO污染物的催化氧化 3.低温等离子体 4.吸脱附等控制技术
  • 4、赵老师：1.高分子材料改性及加工技术 2.微孔及过滤材料 3.环境友好高分子材料
  • 5、邬老师：1.高分子材料的共混与复合 2.涉及材料功能化及结构与性能的研究； 高分子热稳定剂的研发
  • 如您是高校老师，可以点此联系我们加入专家库。
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