缺氧诱导因子1α,HIF-1α
1)HIF-1α缺氧诱导因子1α
1.Objective To investigate the effect of trichostatin A(TSA) on the expression of HIF-1α and VEGF in lung adenocarcinoma cell line A549 under hypoxic condition.目的探讨组蛋白去乙酰化酶1抑制剂曲古抑菌素A(trichostain A,TSA)对低氧条件下人肺腺癌细胞株A549缺氧诱导因子1α(hypoxia induced factor 1α,HIF-1α)和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。
2.HIF-1α,a crucial transcriptional control gene in signaling cell to adapt to anaerobic microenvironment,can activate the expression of many anaerobic-responding genes which includes the expression of Glut1 gene,in order to supply energy for tumor under hypoxia.缺氧诱导因子1α(HIF-1α)是介导细胞对缺氧微环境进行适应性反应的关键性转录调控基因,能激活许多缺氧反应性基因的表达,其中包括促进肿瘤细胞Glut基因的表达,以满足在乏氧状态下,肿瘤生长的能量需求。
3.Hypoxia-inducible factor-1α(HIF-1α) is a nuclear transcription factor which play activity in a state of hypoxia.缺氧诱导因子1α(HIF-1α)是一个在缺氧状态下发挥活性的核转录因子,在胰腺癌组织及细胞中高表达,促进胰腺癌生长和血管生成,缺氧状态下,间质细胞和胰腺癌细胞之间的相互作用增加。
英文短句/例句

1.Gene Cloning of Hypoxia-inducible Factor-1α and Expression Research of HIF-1α-pcDNA3.1;缺氧诱导因子1α基因克隆及HIF-1α-pcDNA3.1表达研究
2.Study of Hypoxia-inducible Factor-1α on Carcinogenesis of Esophageal Squamous Cell Cancer;缺氧诱导因子1α在食管鳞癌发病机制中的研究
3.RESEARCH PROGRESS OF HYPOXIA INDUCIBLE FACTOR 1α IN HYPOXIC-ISCHEMIC INJURY缺氧诱导因子1α在缺氧缺血性损伤中的研究进展
4.Effect of Hypoxia-inducible Factor-1α on Myocardial Ischemia-reperfusion Injury in Rats缺氧诱导因子1α对大鼠心肌缺血-再灌注损伤的保护作用及机制
5.The Effects of Hypoixa-Inducible Factor-1a on Gastric Cancer During Hypoixa;缺氧诱导因子-1α对缺氧胃癌细胞的影响
6.Expression of Hypoxia Inducible Factor la Gene and Protein in Human Endometrium人子宫内膜组织中缺氧诱导因子-1α(HIF-1α)基因和蛋白的表达
7.Correlation of hypoxia inducible factor 1-α polymorphism and nasopharyngeal carcinoma缺氧诱导因子-1α基因多态性与鼻咽癌的关系
8.Experimental Research in Targeting Hypoxia-inducible Factor-1α for Pancreatic Cancer Therapy;缺氧诱导因子-1α在胰腺癌中的靶向治疗研究
9.Research of Hypoxia Inducible Factor-1α in Benign Prostatic Hyperplasia;缺氧诱导因子-1α与良性前列腺增生的研究
10.Expression and Significance of HIF-1α in Human Astrocytoma;人星形细胞瘤中缺氧诱导因子-1α的表达及意义
11.Expression and Clinical Significance of HIF-1α Receptor in Human Hepatocellular Carcinoma;肝细胞癌中缺氧诱导因子-1α的表达及临床意义
12.The study of relationship of hypoxia-inducible factor-1α expression and clinicopathological features and proliferation in ovarian serous cystadenocarcinoma缺氧诱导因子-1α与卵巢浆液性囊腺癌的相关性
13.Expression of hypoxia inducible factor-1α in colorectal tumor:a meta-analysis of case-control trials结直肠肿瘤中缺氧诱导因子-1α表达的Meta分析
14.Hypoxia-inducible factor-1α: a promising target for tumor therapy缺氧诱导因子-1α:很有潜力的肿瘤治疗靶点
15.The Research on Relationship between HIF-1 Alpha Gene and Radiosensitivity in Esophageal Carcinoma Cells;缺氧诱导因子-1α(HIF-1α)表达与食管癌放射敏感性关系的研究
16.Inhibition of the Expression of HIF-1α and Angiogenic Factors with Specific Si RNA Targeting HIF-1α in HCC Cell under Hypoxia;HIF-1α siRNA干扰缺氧诱导人肝癌细胞HIF-1α及血管生成因子的表达
17.The Effect of Hypoxia Inducible Factor 1 Alpha Antisense Oligonucleotides on Cell Proliferation of Cervical Carcinoma;缺氧诱导因子-1α(HIF-1α)反义寡核苷酸对宫颈癌细胞增殖的影响
18.The Effects of Ischemic Preconditioning on the Expression of Hypoxia Inducible Factor-1α Gene in Ischemic Myocardium;缺血预处理对缺血心肌缺氧诱导因子-1α基因表达的影响
相关短句/例句

Hypoxia-inducible factor-1α缺氧诱导因子1α
1.Objective To investigate the expression of hypoxia-inducible factor-1α(HIF-1α) and p53 protein in the development and malignant progression of astrocytomas.目的探讨缺氧诱导因子1α(HIF-1α)与p53在脑星形细胞瘤中表达的生物学意义。
2.Objective To evaluate the effect of hypoxia-inducible factor-1α(HIF-1α)on myocardial ischemia-reperfusion injury in rats.目的观察缺氧诱导因子1α(HIF-1α)对大鼠心肌缺血-再灌注损伤的保护作用。
3)hypoxia inducible factor-1α缺氧诱导因子1α
1.Objective To study the expression of Rac1 and hypoxia inducible factor-1α(HIF-1α) in tissues of experimental choroidal neovascularization(CNV) model in mice and its significance.目的研究Rac1和缺氧诱导因子1α(hypoxia inducible factor1α,HIF-1α)在激光诱导实验性小鼠脉络膜新生血管(choroidal neovascularization,CNV)模型组织中的表达及意义。
2.Objective: To construct a short hairpin RNA(shRNA) vector of the hypoxia inducible factor-1α(HIF-1α),determine its inhibitory effect on the expression of the HIF-1α gene in PC-3M cells,and investigate its application prospects in the treatment of prostate cancer.目的:构建产生缺氧诱导因子1α(HIF-1α)特异性短发夹状RNA(shRNA)的载体并检测其抑制作用,探讨该技术在前列腺癌治疗中的应用前景。
3.Hypoxia inducible factor-1α(HIF-1α),a nuclear protein with transcription activity,producing biological activity respectively.缺氧诱导因子1α(HIF-1α)是一种具有转录活性的核蛋白,能与靶基因结合并通过转录和转录后调控,产生相应的生物活性,使机体在缺血缺氧时产生适应性反应。
4)Hypoxia-inducible factor 1α缺氧诱导因子1α
1.Objective To observe the expression of hypoxia-inducible factor 1α(HIF-1α)in rats with cerebral hypoxia and the effect of ginsenoside Rd on HIF-1α expression.目的观察大鼠脑缺氧状态下缺氧诱导因子1α(HIF-1α)蛋白的表达及低氧状态下人参皂甙Rd干预对其影响。
5)hypoxia inducible factor 1α缺氧诱导因子1α
1.Objective To construct a prokaryotic expression vector for a fusion protein, TAT protein transduction domain (PTD) and the PAS-B domain of hypoxia inducible factor 1α(HIF-1α), and then express and purifr the fusion protein.目的构建蛋白转导结构域TAT和人缺氧诱导因子1αPAS-B结构域融合蛋白的原核表达载体,并在大肠杆菌中表达及纯化。
2.Objective: To acquire the distribution of hypoxia inducible factor 1αC2028T polymorphism of Guangxi healthy population and patients with nasopharyngeal carcinoma, analyze it’s association with the main clinicopathologic features of nasopharyngeal carcinoma patients synthetically, and inspect it’s role in the carcinogenesis and development of nasopharyngeal carcinoma.目的:检测广西地区正常人群缺氧诱导因子1αC2028T多态性,获取该人群多态性的分布情况,同时观察此多态性在鼻咽癌患者的分布,结合患者主要临床病理参数,初步探讨缺氧诱导因子1αC2028T多态性在鼻咽癌发生发展中的作用和意义。
6)Hypoxia-inducible factor-1α缺氧诱导因子-1α
1.Expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in the retina of diabetic rats;糖尿病大鼠视网膜中缺氧诱导因子-1α和血管内皮生长因子表达的研究
2.Effects of Chinese herbs for replenishing qi and resolving stagnation on hypoxia-inducible factor-1α and vascular endothelial growth factor in granulation tissue of skin ulcers in rats with diabetes;益气化瘀中药对糖尿病皮肤溃疡大鼠缺氧诱导因子-1α和血管内皮细胞生长因子的影响
3.Expression of hypoxia-inducible factor-1α in endometriosis;缺氧诱导因子-1α在子宫内膜异位症的表达及意义
延伸阅读

α,α,α,α',α',α'-六氯对二甲苯分子式:C8H4Cl6分子量:312.84CAS号:68-36-0性质:白色针状或粉末状结晶。熔点108-110℃。溶于二甲苯、石油醚、乙醇、植物油,不溶于水。无味,有特殊臭味,遇光、碱会缓慢分解而呈酸性。制备方法:以混二甲苯为原料,先用98%硫酸磺化,使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层,水洗、干燥,减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1,4-双(三氯甲基)苯:在反应锅中投入邻、对二甲苯,再加入过氧化苯甲酰和三乙醇胺。加热到70℃后,在光照射下导入氯气,于70-80℃反应6h,再升温至100-120℃继续反应,至反应液相对密度达到1.560-1.580(65℃),即为反应终点,停止通氯,减压脱除余氯。降温至5℃,过滤,洗涤得粗品,重结晶,活性炭脱色得成品。用途:抗血吸虫病药物。对肝吸虫病、阿米巴原虫病、疟疾以及肠道线虫有一定疗效。但对神经系统的不良反应较多见,且延迟反应持续较久。