1)β-catenin geneβ-catenin基因
1.Abnormalities of APC gene/β-catenin gene in Wnt pathway in desmoid-type fibromatosis;韧带样型纤维瘤病Wnt通路中APC/β-catenin基因异常
2.Objective To explore the relationship of the expression of β-catenin gene with pathological type of craniopharyngiomas and prognosis of the patients with craniopharyngiomas.目的探讨β-catenin基因和颅咽管瘤病理类型及预后的关系。
3.PurposeTo analyze the clinicopathologic features of desmoid-type fibromatosis, and to detect trisomy 8 and mutations of the APC gene and β-catenin gene in this tumor with a purpose of exploring the mechanism of the tumorigenesis and progression of this disease.运用免疫组织化学EnVision~+两步法检测69例存档石蜡包埋组织中β-catenin、cyclinD1、c-myc、Ki-67等蛋白的表达;用DNA末端转移酶介导的缺口标记法(Terminal Deoxynucleotidyl Transferase biotin-dUTP Nick End Labeling,TUNEL)检测病变中细胞凋亡;用聚合酶链反应(PCR)-变性液相高效质谱分析(Denaturing High Performance Liquid Chromatography,DHPLC)-直接测序的方法检测APC和β-catenin基因突变。
英文短句/例句
1.RNAi Specifically Inhibits the Expression of β-catenin Gene in Gastric Carcinoma Cells;RNAi特异性抑制胃癌细胞β-catenin基因表达的研究
2.Construction and identification of shRNA eukaryotic vector targeting human β-catenin针对人β-catenin基因shRNA真核表达载体的构建与鉴定
3.Cloning and Bioinformatics Analysis of cDNA of β-catenin Gene in Peking Duck北京鸭β-catenin基因cDNA的克隆和生物信息学分析
4.Study the Significance for Cell Apoptosis and β-catenin Gene Effected on Craniopharyngioma in Aetiology and Prognosis;细胞凋亡及β-catenin基因在颅咽管瘤发病及预后中的意义探讨
5.A Clinicopathologic Study of Cystic and Solid Tumors of Pancreas and the Analysis of β-catenin Mutation;胰腺囊性-实性肿瘤临床病理学及β-catenin基因突变研究
6.Expression of APC and β-catenin Gene and Their Clinical Significance in Human Sporadic Colorectal Carcinoma;散发性结直肠腺癌APC、β-catenin基因的表达及其临床意义
7.The Peking Duck Embryo Follicle of Developmental Characteristics and β-Catenin Gene Cloning and Expression北京鸭胚胎期皮肤毛囊的发育特征及β-catenin基因的克隆与表达
8.Relationship between gene expression of β-catenin and embryonic neural tube defects induced by Retinoic acid维甲酸诱导胚胎神经管畸形与β-catenin基因表达的关系
9.Correlation of genetic polymorphisms of β-catenin to hepatitis B virus-related hepatocellular carcinomaβ-catenin基因多态性与乙型肝炎病毒相关肝细胞癌易感性的关系
10.The Role of Methylation in Runx_3 and Expressions of TGF-β1/β-catenin in Oncogenesis of Colonic CarcinomaRunx3基因甲基化及TGF-β1、β-catenin在结肠癌发生中的作用
11.Negative Regulation of β-catenin Signal Pathway by Pancreas Duodenum Homeobox-1;胰、十二指肠同源盒基因-1对β-catenin信号通路的调节机制研究
12.Studies on β-Catenin Mutation and Aberrant Expression in Sporadic Colorectal Cancers and Raman Spectra of Single Optically Trapped Sporadic Colorectal Cancer Cells;散发性结直肠癌的β-Catenin基因突变及表达和单细胞拉曼光谱研究
13.Studying on the Relevance Between Aging Kidney-Yang Deficiency Syndrome and the Wnt/β-catenin Signaling Pathway by cDNA Microarray Assay运用基因芯片技术分析老龄肾阳虚证与Wnt/β-catenin信号通路的相关性
14.Detection of Beta-Catenin Protein Expression and Gene Mutation in Tumorigenesis of Endometrioid Adenocarcinoma子宫内膜样腺癌发生过程中β-catenin蛋白异常表达和基因突变的检测
15.Aberrant expression and mutation of β-catenin in sporadic colorectal cancerβ-Catenin蛋白在散发性结直肠癌中的异常表达和基因突变
16.LIVIN GENE EXPRESSION IN COLORECTAL CANCER AND ITS RELATIONSHIP WITH PTEN,β-CATENIN RELATED RESEARCHLivin基因在结直肠癌的表达及其与PTEN、β-Catenin的相关性研究
17.Effects of Altered Distribution of β-catenin and Related Influence Factors on Progression of Colorectal Cancer in Chinese;β-catenin异位分布及影响因素在我国结直肠癌发生演进中的作用
18.Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells肺癌细胞系中p120-catenin的基因缺失调控small GTP酶活性
相关短句/例句
beta-catenin genebeta-catenin基因
3)γ-catenin geneγ-catenin基因
1.Effect of 5-Aza-2’-deoxycytidine on growth inhibition of renal carcinoma cell line OS-RC-2 and reversion of γ-catenin gene hypermethylation5-氮杂-2’-脱氧胞苷抑制肾癌细胞增殖及逆转γ-catenin基因甲基化作用
2.Objective:To investigate the influence of 5-Aza-2\'-deoxycytidine (5-Aza-CdR) on the proliferation and apoptosis of human renal carcinoma cell line OS-RC-2,and to study the influence of 5-Aza-CdR on methylati on ofγ-catenin gene,so as to provide insights into origin of renal carcinoma and the possibility of its application in clinical treatment.目的:研究5-氮杂-2′-脱氧胞苷(5-Aza-CdR)对人肾癌OS-RC-2细胞株增殖、凋亡的影响,进一步分析5-Aza-CdR处理对γ-catenin基因甲基化状态的影响,初步探讨肾癌发病机制及临床治疗的可行性。
3.The methylation status of γ-catenin gene promoter region was reversed with 5-Aza-CdR 10-5mol/L treating for 72h.以甲基化特异性PCR(MSP)检测细胞处理前后γ-catenin基因的甲基化状态。
4)beta-cateninβ-catenin
1.Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma;β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达
2.The modulations of beta-catenin and caspase-3 levels were investigated in the KM mouse embryo following maternal treatme.用 RT-PCR 及蛋白质印迹技术,探测了过量维甲酸对昆明小鼠胚胎神经管中维甲酸受体α/β及β-catenin 和 caspase-3 基因表达的调整。
3.Objects: To investigate the interaction between HBX protein and beta-catenin, illuminate the molecular mechanism in HBV-associated hepatocellular carcinoma (HCC) carcinogenesis and the important role of wnt/β-catenin signaling pathway in the generation/differentiation of many tissues.目的:利用HBX腺病毒质粒载体,转染人肝细胞株L02,观察HBX对?-catenin表达量及转录活性的影响,研究HBX与Wnt/β-catenin信号转导通路中主要信号分子的相互作用,确定HBX与β-catenin的内在联系,旨在探讨HBV相关性HCC的发生机制,阐明Wnt/β-catenin信号转导途径在胚胎发育和肿瘤发生过程中的重要作用。
5)hepatocyte-specificβ-catenin deletion肝细胞特异性β-catenin基因敲除
6)β-catenin proteinβ-catenin蛋白
1.expression and the clinical signincance of survivin protein and β-catenin protein in primary hepatocellular carcinoma (HCC);Survivin蛋白及β-catenin蛋白在原发性肝癌组织中的表达及其临床意义
延伸阅读
β-catenin分子式:CAS号:性质:原癌基因编码的蛋白质,参与钙依黏附蛋白(cadehrin)胞内结构域介导的信号转导的重要分子。正常细胞内它的浓度较低。在由它介导信号转导的结果中都发现APC(adenomatous polyposis coli,是一种肿瘤抑制蛋白质),是一个β-连蛋白信号转导的负调节剂。显然β-连蛋白在恶性肿瘤病因研究领域中占有相当重要的地位。一旦APC或β连蛋白发生突变,即可发生信号转导减弱,细胞增殖加快与抑制细胞凋亡等作用,这是至今所了解的正常细胞发生恶变的β-连蛋白作用分子机制。
