本发明涉及生物医药领域，具体而言，涉及一种融合蛋白及其应用。
背景技术：
所有病毒都有核酸(包括dna和rna)，并且都以核酸作为寄生存活的根本。目前应对病毒传染病(例如新冠病毒、hiv等等)主要寄希望于疫苗。疫苗开发难度大，时间长，效果也因人而异，在特殊情况下，疫苗可能不起应有的作用甚至起反作用。故有必要开发一种以直接杀灭病毒为主的组合型预防和治疗病毒疾病的方法。
有鉴于此，特提出本发明。
技术实现要素：
这种方法的关键特点是通过蛋白融合(核酸酶-病毒识别蛋白融合体)或者载体结合(核酸酶-病毒识别载体)的方式，将一般性降解病毒核酸的工具酶与病毒的特异性受体以及抗体有机结合在一起，直接针对性地杀灭特定病毒。这种方法以核酸酶降解病毒核酸为主攻武器，以病毒的特异性受体以及抗体为主要开关，配合以病毒特异性融膜分子、病毒特异性融膜载体(包括脂质体、纳米颗粒、红细胞，功能性活细胞等)作为病毒攻击通道。
本方法使用的核酸酶包括所有能够降解病毒核酸的工具酶，例如各种rnase，dnase，ribozyme，sirna，crispr介导的dna酶和rna酶等等。
本方法使用的病毒的特异性受体以及抗体包括所有能够与特定病毒组成成分特异性能够结合的一般分子，其中特别包括病毒的受体以及所有能够与特定病毒组成成分特异性结合的抗体，例如新冠病毒的受体ace2以及各种抗新冠病毒s蛋白，e蛋白，m蛋白，n蛋白抗体等等。
本方法使用的蛋白融合(核酸酶-病毒识别蛋白融合体)方式包括将核酸酶通过共价键融合连接到各种特定病毒识别蛋白体的n端或者c端。例如特定病毒受体的n端或者c端，以及将核酸酶通过共价键融合连接到特定病毒抗体轻链的n端或者c端，或者连接到特定病毒抗体重链的n端或者c端。
本方法使用的病毒特异性融膜载体包括脂质体、纳米颗粒、红细胞，各种功能性活细胞等等。
本方法使用的载体结合(核酸酶-病毒识别载体)方式包括将针对特定病毒核酸的核酸酶放入病毒特异性融膜载体内部，将特定病毒识别蛋白体(例如病毒受体和抗体等等)放到病毒特异性融膜载体表面。
在使用各种功能性活细胞作为核酸酶-病毒识别载体的方式中，一般采用基因表达载体的方式将针对特定病毒中特定核酸序列的特异性核酸酶(例如ribozyme，sirna,crispr介导的dna酶和rna酶等等)放入病毒特异性融膜载体内部，将特定病毒识别蛋白体(例如病毒受体和抗体等等)放到病毒特异性融膜载体表面。
本发明采用了如下技术方案：
本发明提供一种预防和治疗病毒性传染病的融合蛋白，其特征在于，包括：核酸酶、病毒抗体或病毒受体。
进一步，本发明的预防和治疗病毒性传染病的融合蛋白，其特征在于，还包括：病毒特异性融膜载体。
本发明还提供一种预防和治疗新冠状病毒传染病的融合蛋白，其特征在于，包括：核酸酶、新冠病毒抗体或病毒受体。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于，包括：新冠病毒受体。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于：所述新冠病毒受体为ace2及其改造形式，新冠病毒抗体为cr3022及其改造形式。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于，还包括：核糖核酸酶。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于：所述核糖核酸酶为rnase7、rnase2、rnasek、rnaset2、xrn2、xrn1或新冠状病毒rna序列特异性的rnasep。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于，还包括：co-receptors(受体)：为cd147、dc-sign(cd209)、l-sign(cd209l)、clec4g、anpep、enpep或dpp4。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，其特征在于，融合蛋白的序列如本文二十三个实施例(1-23)所示。
进一步，本发明的预防和治疗新冠状病毒传染病的融合蛋白，融合蛋白为新冠病毒受体-新冠病毒抗体-核糖核酸酶形式。
本发明还提供一种识别新冠病毒的rna酶-红细胞载体，首先通过基因表达载体将新冠病毒的受体ace2m(h374d,h378d)和cd147以及抗新冠病毒的抗体(igm完整形式)表达在人脐带血中的cd34阳性细胞hematopoieticstemcells(hscs)表面，然后诱导生成成熟的无核红细胞，然后采用短暂低渗透压的方法将rnase7，rnase2，xrn2，xrn1放到红细胞内部。
本发明还提供一种识别新冠病毒的rna酶-功能性活细胞载体，首先通过基因表达载体将新冠病毒的受体ace2m(h374d,h378d)，cd147，抗新冠病毒的抗体，以及专门识别并且特异性切断新冠病毒rna保守序列的rnasep在人脐带血或者其他有核细胞中表达。
本发明的预防和治疗病毒性传染病的多功能融合蛋白和多功能载体，开发速度比疫苗更快而且更容易，安全性和有效性把握性更大。可以推广应用到各种病毒传染病的预防和治疗中。
具体实施方式
下面以新冠病毒为主进行具体说明，当然，相似的蛋白结构和开发方式开发所得到的成果可以应用到其它各种细胞特异性病毒传染病。
实施例一
本实施例的融合蛋白ace2-hufc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染，融合蛋白序列如下：
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
本实施例及以下一些实施例中，每个融合蛋白分子的第一行是用于细胞分泌的信号肽，最终的纯化产品不包括信号肽。如果用昆虫细胞表达可以换成gp64或者gp67信号肽,如果用细菌表达需要将信号肽替换成起始密码。融合蛋白的各部分以gsgg或者ggsgg的连接序列进行连接。
实施例二
本实施例的融合蛋白ace2-hufc(g1+m)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染，融合蛋白序列如下：
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例三
本实施例的融合蛋白ace2m(h374d,h378d)-hufc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：(ace2序列中374位的h，修改为d，378位的h，也修改为d):
msssswlllslvavtaaq(信号肽)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahdemgdiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例四
本实施例的融合蛋白ace2m(h374d,h378d)-hufc(g1+m)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：(ace2序列中374位的h，修改为d，378位的h，也修改为d):
msssswlllslvavtaaq(信号肽)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahdemgdiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例五
本实施例的融合蛋白ace2-hufc(g1)-rnase2，用于鼻腔和眼睛点滴而预防新冠病毒传染，融合蛋白序列如下：
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
slhvkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntf
llttfanvvnvcgnpnmtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdn
rdqrrdppqypvvpvhldrii
实施例六
本实施例的融合蛋白ace2-hufc(g1+m)-rnase2，用于鼻腔和眼睛点滴而预防新冠病毒传染，融合蛋白序列如下：
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
ggsgg
slhvkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntf
llttfanvvnvcgnpnmtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdn
rdqrrdppqypvvpvhldrii
实施例七
本实施例的融合蛋白anti-sars-cov2-higg1+anti-sars-cov2-hk-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
anti-sars-cov2-hk-rnase7:
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例八
本实施例的融合蛋白anti-sars-cov2-higg1+m+anti-sars-cov2-hk-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1+m:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
anti-sars-cov2-hk-rnase7:
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例九
本实施例的融合蛋白anti-sars-cov2-higg1+anti-sars-cov2-hk-rnasek，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
anti-sars-cov2-hk-rnasek:
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
ggsgg
masllccgpklaacgivlsawgvimlimlgiffnvhsavliedvpftekdfengpqniynlyeqvsyncf
iaaglylllggfsfcqvrlnkrkeymvr
实施例十
本实施例的融合蛋白anti-sars-cov2-higg1+m+anti-sars-cov2-hk-rnasek，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1+m:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
anti-sars-cov2-hk-rnasek:
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
ggsgg
masllccgpklaacgivlsawgvimlimlgiffnvhsavliedvpftekdfengpqniynlyeqvsyncf
iaaglylllggfsfcqvrlnkrkeymvr
实施例十一
本实施例的融合蛋白anti-sars-cov2-higg1+anti-sars-cov2-hk-ribonucleaset2，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
anti-sars-cov2-hk-ribonucleaset2:
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
ggsgg
mraywpdvihsfpnrsrfwkhewekhgtcaaqvdalnsqkkyfgrslelyreldlnsvllklgikpsiny
yqvadfkdalarvygvipkiqclppsqdeevqtigqielcltkqdqqlqnctepgeqpspkqevwlanga
aesrglrvcedgpvfypppkktkh
实施例十二
本实施例的融合蛋白anti-sars-cov2-higg1+rnase2-anti-sars-cov2-hk，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
anti-sars-cov2-higg1:
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvti
sadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
astkgpsvfplapssk
stsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpss
slgtqtyicnvnhkpsntkvdkrvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvf
scsvmhealhnhytqkslslspgk
rnase2-anti-sars-cov2-hk:
slhvkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntf
llttfanvvnvcgnpnmtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdn
rdqrrdppqypvvpvhldrii
ggsgg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsg
sgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec
实施例十三
本实施例的融合蛋白ace2p1-cr3022vlvh-hfc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfril
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
gggsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsggg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例十四
本实施例的融合蛋白ace2p1m1-cr3022vlvh-hfc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldlfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfril
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
gggsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsggg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例十五
本实施例的融合蛋白ace2p1-cr3022vhvl-cd147-hfc(g1)-rnase2，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfril
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggsggggsgggsgggsggsg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
slhvkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntf
llttfanvvnvcgnpnmtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdn
rdqrrdppqypvvpvhldrii
实施例十六
本实施例的融合蛋白ace2p1m2-cr3022vhvl-cd147-hfc(g1)-rnase2，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnfeaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfril
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggsggggsgggsgggsggsg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
slhvkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntf
llttfanvvnvcgnpnmtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdn
rdqrrdppqypvvpvhldrii
实施例十七
本实施例的融合蛋白ace2p2m1-cr3022vlvh-hfc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldlfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
gggsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例十八
本实施例的融合蛋白ace2p2-cr3022vlvh-hfc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
gggsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例十九
本实施例的融合蛋白ace2p2m-cr3022vlvh-cd147-hfc(g1)-rnase7用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldlfnfeaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例二十
本实施例的融合蛋白ace2p2-cr3022vlvh-cd147-hfc(g1)-rnase7，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggsggggsgggsgggsggsg
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
实施例二十一
本实施例的融合蛋白ace2p2m2-cr3022vhvl-cd147-hfc(g1)-rnaset2，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnfeaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggsggggsgggsgggsggsg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
mraywpdvihsfpnrsrfwkhewekhgtcaaqvdalnsqkkyfgrslelyreldlnsvllklgikpsiny
yqvadfkdalarvygvipkiqclppsqdeevqtigqielcltkqdqqlqnctepgeqpspkqevwlanga
aesrglrvcedgpvfypppkktkh
实施例二十二
本实施例的融合蛋白ace2p2-cr3022vhvl-cd147-hfc(g1)-rnaset2，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggsggggsgggsgggsggsg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
ggggsggggsggggsggggsggggsggggsggggsggggsggggs
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsgg
mraywpdvihsfpnrsrfwkhewekhgtcaaqvdalnsqkkyfgrslelyreldlnsvllklgikpsiny
yqvadfkdalarvygvipkiqclppsqdeevqtigqielcltkqdqqlqnctepgeqpspkqevwlanga
aesrglrvcedgpvfypppkktkh
实施例二十三
本实施例的融合蛋白ace2p2m-cr3022vhvl-cd147-hfc(g1)-rnasek，用于鼻腔和眼睛点滴而预防新冠病毒传染或者静脉注射治疗，融合蛋白序列如下：
mgs
stieeqaktfldlfnfeaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystg
ggggsggggsggggs
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
ggsggggsgggsgggsggsg
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikr
gggsgggsgggsggg
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
gggsgggsggg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
ggsggg
masllccgpklaacgivlsawgvimlimlgiffnvhsavliedvpftekdfengpqniynlyeqvsyncf
iaaglylllggfsfcqvrlnkrkeymvr
实施例二十四
识别新冠病毒的rna酶-红细胞载体
在gmp条件下，首先通过基因表达载体将新冠病毒的受体ace2m(h374d,h378d)和cd147以及抗新冠病毒的抗体(igm完整形式)表达在人脐带血中的cd34阳性细胞hematopoieticstemcells(hscs)表面，然后诱导生成成熟的无核红细胞。然后采用短暂低渗透压的方法将rnase7，rnase2，xrn2，xrn1放到红细胞内部。组装好的细胞经过鉴定和政府批准后静脉注射用于治疗新冠病毒传染病人。
>np_001304889.15'-3'exoribonuclease2isoform1[homosapiens]xrn2
mgsaacprgalpelapccqpreqsqphtrwdagcgiqhpggeefrtlggarayrvpnsqegrssptrffp
apegpahcfvsspdrafwvseevqrlllsnacqpkecngvkipvdaskpnpndvefdnlyldmngiihpc
thpedkpapknedemmvaifeyidrlfsivrprrllymaidgvaprakmnqqrsrrfraskegmeaavek
qrvreeilakggflppeeikerfdsncitpgtefmdnlakclryyiadrlnndpgwknltvilsdasapg
egehkimdyirrqraqpnhdpnthhclcgadadlimlglathepnftiireefkpnkpkpcglcnqfghe
vkdceglprekkgkhdeladslpcaegefiflrlnvlreylereltmaslpftfdversiddwvfmcffv
gndflphlpsleirenaidrlvniyknvvhktggyltesgyvnlqrvqmimlavgevedsifkkrkdded
sfrrrqkekrkrmkrdqpaftpsgiltphalgsrnspgsqvasnprqaayemrmqnnsspsispntsfts
dgspsplggikrkaedsdsepepednvrlweagwkqryyknkfdvdaadekfrrkvvqsyveglcwvlry
yyqgcaswkwyypfhyapfasdfegiadmpsdfekgtkpfkpleqlmgvfpaasgnflppswrklmsdpd
ssiidfypedfaidlngkkyawqgvallpfvderrlraaleevypdltpeetrrnslggdvlfvgkhhpl
hdfilelyqtgstepvevppelchgiqgkfsldeeailpdqivcspvpmlrdltqntvvsinfkdpqfae
dyifkavmlpgarkpaavlkpsdwekssngrqwkpqlgfnrdrrpvhldqaafrtlghvmprgsgtgiys
naapppvtyqgnlyrpllrgqaqipklmsnmrpqdswrgppplfqqqrfdrgvgaepllpwnrmlqtqna
afqpnqyqmlagpggypprrddrggrqgypregrkyplpppsgrynwn
>np_001269786.15'-3'exoribonuclease1isoformc[homosapiens]xrn1
mgvpkfyrwiserypclsevvkehqipefdnlyldmngiihqcshpndddvhfrisddkiftdifhylev
lfriikprkvffmavdgvaprakmnqqrgrrfrsakeaedkikkaiekgetlptearfdsncitpgtefm
arlhehlkyfvnmkistdkswqgvtiyfsghetpgegehkimefirsekakpdhdpntrhclygldadli
mlgltsheahfsllreevrfggkktqrvcapeettfhllhlslmreyidyefsvlkekitfkydieriid
dwilmgflvgndfiphlphlhinhdalpllygtyvtilpelggyinesghlnlprfekylvklsdfdreh
fsevfvdlkwfeskvgnkylneaagvaaeearnykekkklkgqenslcwtaldknegemitskdnledet
edddlfetefrqykrtyymtkmgvdvvsddfladqaacyvqaiqwilhyyyhgvqswswyypyhyapfls
dihnistlkihfelgkpfkpfeqllavlpaasknllpacyqhlmtnedspiieyyppdfktdlngkqqew
eavvlipfidekrlleametcnhslkkeerkrnqhseclmcwydrdtefiypspwpekfpaiercctryk
iisldawrvdinknkitridqkalyfcgfptlkhirhkfflkksgvqvfqqssrgenmmleilvdaesde
ltvenvassvlgksvfvnwphleearvvavsdgetkfyleeppgtqklysgrtappskvvhlgdkeqsnw
akevqgisehylrrkgiiinetsavvyaqlltgrkyqinqngevrlekqwskqvvpfvyqtivkdirafd
srfsniktlddlfplrsmvfmlgtpyygctgevqdsgdvitegrirvifsipcepnldaliqnqhkysik
ynpgyvlasrlgvsgylvsrftgsifigrgsrrnphgdhkanvglnlkfnkkneevpgytkkvgsewmys
saaeqllaeylerapelfsyiaknsqedvfyeddiwpgenengaekvqeiitwlkghpvstlsrsscdlq
ildaaivekieeevekckqrknnkkvrvtvkphllyrpleqqhgvipdrdaefclfdrvvnvrenfsvpv
glrgtiigikganreadvlfevlfdeefpggltircspgrgyrlptsalvnlshgsrsetgnqkltaivk
pqpavhqhsssssvssghlgalnhspqslfvptqvptkdddefcniwqslqgsgkmqyfqptiqekgavl
pqeisqvnqhhksgfndnsvkyqqrkhdphrkfkeeckspkaecwsqkmsnkqpnsgienflaslniske
nevqsshhgeppseehlspqsfamkgtrmlkeilkidgsntvdhkneikqianeipvssnrrdeyglpsq
pkqnkklasymnkphsaneyhnvqsmdnmcwpapsqippvstpvtelsricslvgmpqpdfsflrmpqtm
tvcqvklsngllvhgpqchseneakekaalfalqqlgslgmnfplpsqvfanypsavppgtippafpppt
animpssshlfgsmpwgpsvpvpgkpfhhtlysgtmpmaggipggvhnqfiplqvtkkrvankknfenke
aqssqatpvqtsqpdssnivkvspresssaslksspiaqpassfqvetasqghsishhkstpisssrrks
rklavnfgvskpse
>bac76828.1cd147[homosapiens]
maaalfvllgfallgthgasg
aagtvfttvedlgskilltcslndsatevtghrwlkggvvlkedalpgq
ktefkvdsddqwgeyscvflpepmgtaniqlhgpprvkavkssehinegetamlvcksesvppvtdwawy
kitdse
dkalmngsesrffvsssqgrselhienlnmeadpgqyrcngtsskgsdqaiitlrvrshlaalw
pllgivaevlvlvtiifiyekrrkpedvlddddagsaplkssgqhqndkgknvrqrnss
ace2m(h374d,h378d)
msssswlllslvavtaaq
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkws
aflkeqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqe
clllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevn
gvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlys
ltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahdemgdiqydmayaaqpfllrnganegfheavgeimslsaatpkhlks
igllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep
vphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl
gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad
qsikvrislksalgd
rayewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtev
ekairmsrsrindafrlndnsleflgiqptlgppnqppvs
iwlivfgvvmgvivvgiviliftgirdrkk
knkarsgenpyasidiskgennpgfqntddvqtsf
smcvpdqdtairvfaippsfasifltkstkltclvtdlttydsvtiswtrqngeavkthtniseshpnat
fsavgeasiceddwnsgerftctvthtdlpsplkqtisrpkgvalhrpdvyllppareqlnlresatitc
lvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsiltvseeewntgetytcvvahealp
nrvtertvdkstgkptlynvslvmsdtagtcy
kpkgmtssqwfkiqhmqpspqacnsamkninkhtkrckdlnt
flhepfssvaatcqtpkiackngdknchqshgavsltmckltsgkhpncrykekrqnksyvvackppqkk
dsqqfhlvpvhldrvl
anti-sars-cov2-scfv-hufc(g-m)
mplllllpllwagala
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastresgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikggsggggsgggsggggsgggsgmqmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetryspsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvss
gsgg
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcv
vvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapi
ektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
pdvyllppareqlnlresatitclvtgfspadvfvqwmqrgqplspekyvtsapmpepqapgryfahsil
tvseeewntgetytcvvahealpnrvtertvd
kstgkptlynvslvmsdtagtcy
实施例二十五
识别新冠病毒的rna酶-功能性活细胞载体
在gmp条件下，首先通过基因表达载体将新冠病毒的受体ace2m(h374d,h378d)，cd147，抗新冠病毒的抗体，以及专门识别并且特异性切断新冠病毒rna保守序列的rnasep在人脐带血或者其他合适的有核细胞中表达。组装好的细胞经过鉴定和政府批准后静脉注射用于治疗新冠病毒传染病人。
ace2m(h374d,h378d)，cd147，抗新冠病毒的抗体序列与上面相同，专门识别并且特异性切断新冠病毒rna保守序列的rnasep序列如下：
(用u6或者h1promoter表达)
m1(g33cg205cc326t)rnaseprdrp1
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
caaagaagaagtgcca
m1(g33cg205cc326t)rnaseprdrp2
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
ctgatatcacacatcca
m1(g33cg205cc326t)rnaseprdrp3
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
tctgatcccaatatcca
m1(g33cg205cc326t)rnaseprdrp4
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
gtctcttaactacacca
m1(g33cg205cc326t)rnaseprdrp5
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
gcgagctctattctcca
m1(g33cg205cc326t)rnaseprdrp6
gaagctgaccagacagtcgccgcttcgtcgtcctcctcttcgggggagacgggcggaggggaggaaagtccgggctccatagggcagggtgccaggtaacgcctgggggggaaacccacgaccagtgcaacagagagcaaaccgccgatggcccgcgcaagcgggatcaggtaagggtgaaagggtgcggtaagagcgcaccgcccggctggtaacagtccgtggcacggtaaactccacccggagcaaggccaaataggggttcataaggtacggcccgtactgaacccgggtaggctgcttgagccagtgagcgattgctggcttagatgaatgactgtccacgacagaacccggcttatcggtcagtttcacct
cacactcattagctcca
尽管已用具体实施例来说明和描述了本发明，然而应意识到，在不背离本发明的精神和范围的情况下可以作出许多其它的更改和修改。因此，这意味着在所附权利要求中包括属于本发明范围内的所有这些变化和修改。
sequencelisting
<110>维亚生物科技（上海）有限公司
<120>一种融合蛋白及其应用
<130>jsp12001319
<160>39
<170>patentinversion3.3
<210>1
<211>1086
<212>prt
<213>artificial
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serthrileglugluglnalalysthrpheleuasplyspheasnhis
151015
glualagluaspleuphetyrglnserserleualasertrpasntyr
202530
asnthrasnilethrglugluasnvalglnasnmetasnasnalagly
354045
asplystrpseralapheleulysgluglnserthrleualaglnmet
505560
tyrproleuglngluileglnasnleuthrvallysleuglnleugln
65707580
alaleuglnglnasnglyserservalleusergluasplysserlys
859095
argleuasnthrileleuasnthrmetserthriletyrserthrgly
100105110
lysvalcysasnproaspasnproglnglucysleuleuleuglupro
115120125
glyleuasngluilemetalaasnserleuasptyrasngluargleu
130135140
trpalatrpglusertrpargsergluvalglylysglnleuargpro
145150155160
leutyrgluglutyrvalvalleulysasnglumetalaargalaasn
165170175
histyrgluasptyrglyasptyrtrpargglyasptyrgluvalasn
180185190
glyvalaspglytyrasptyrserargglyglnleuilegluaspval
195200205
gluhisthrpheglugluilelysproleutyrgluhisleuhisala
210215220
tyrvalargalalysleumetasnalatyrprosertyrileserpro
225230235240
ileglycysleuproalahisleuleuglyaspmettrpglyargphe
245250255
trpthrasnleutyrserleuthrvalpropheglyglnlysproasn
260265270
ileaspvalthraspalametvalaspglnalatrpaspalaglnarg
275280285
ilephelysglualaglulysphephevalservalglyleuproasn
290295300
metthrglnglyphetrpgluasnsermetleuthraspproglyasn
305310315320
valglnlysalavalcyshisprothralatrpaspleuglylysgly
325330335
asppheargileleumetcysthrlysvalthrmetaspasppheleu
340345350
thralahishisglumetglyhisileglntyraspmetalatyrala
355360365
alaglnpropheleuleuargasnglyalaasngluglyphehisglu
370375380
alavalglygluilemetserleuseralaalathrprolyshisleu
385390395400
lysserileglyleuleuserproasppheglngluaspasngluthr
405410415
gluileasnpheleuleulysglnalaleuthrilevalglythrleu
420425430
prophethrtyrmetleuglulystrpargtrpmetvalphelysgly
435440445
gluileprolysaspglntrpmetlyslystrptrpglumetlysarg
450455460
gluilevalglyvalvalgluprovalprohisaspgluthrtyrcys
465470475480
aspproalaserleuphehisvalserasnasptyrserpheilearg
485490495
tyrtyrthrargthrleutyrglnpheglnpheglnglualaleucys
500505510
glnalaalalyshisgluglyproleuhislyscysaspileserasn
515520525
serthrglualaglyglnlysleupheasnmetleuargleuglylys
530535540
sergluprotrpthrleualaleugluasnvalvalglyalalysasn
545550555560
metasnvalargproleuleuasntyrphegluproleuphethrtrp
565570575
leulysaspglnasnlysasnserphevalglytrpserthrasptrp
580585590
serprotyralaaspglnserilelysvalargileserleulysser
595600605
alaleuglyaspargalatyrglutrpasnaspasnglumettyrleu
610615620
pheargserservalalatyralametargglntyrpheleulysval
625630635640
lysasnglnmetileleupheglyglugluaspvalargvalalaasn
645650655
leulysproargileserpheasnphephevalthralaprolysasn
660665670
valseraspileileproargthrgluvalglulysalaileargmet
675680685
serargserargileasnaspalapheargleuasnaspasnserleu
690695700
glupheleuglyileglnprothrleuglyproproasnglnpropro
705710715720
valserglyserglyglyasplysthrhisthrcysproprocyspro
725730735
alaprogluleuleuglyglyproservalpheleupheproprolys
740745750
prolysaspthrleumetileserargthrprogluvalthrcysval
755760765
valvalaspvalserhisgluaspprogluvallyspheasntrptyr
770775780
valaspglyvalgluvalhisasnalalysthrlysproarggluglu
785790795800
glntyrasnserthrtyrargvalvalservalleuthrvalleuhis
805810815
glnasptrpleuasnglylysglutyrlyscyslysvalserasnlys
820825830
alaleuproalaproileglulysthrileserlysalalysglygln
835840845
proarggluproglnvaltyrthrleuproproserargaspgluleu
850855860
thrlysasnglnvalserleuthrcysleuvallysglyphetyrpro
865870875880
seraspilealavalglutrpgluserasnglyglnprogluasnasn
885890895
tyrlysthrthrproprovalleuaspseraspglyserphepheleu
900905910
tyrserlysleuthrvalasplysserargtrpglnglnglyasnval
915920925
phesercysservalmethisglualaleuhisasnhistyrthrgln
930935940
lysserleuserleuserproglylysglyglyserglyglylyspro
945950955960
lysglymetthrserserglntrpphelysileglnhismetglnpro
965970975
serproglnalacysasnseralametlysasnileasnlyshisthr
980985990
lysargcyslysaspleuasnthrpheleuhisglupropheserser
99510001005
valalaalathrcysglnthrprolysilealacyslysasngly
101010151020
asplysasncyshisglnserhisglyalavalserleuthrmet
102510301035
cyslysleuthrserglylyshisproasncysargtyrlysglu
104010451050
lysargglnasnlyssertyrvalvalalacyslysproprogln
105510601065
lyslysaspserglnglnphehisleuvalprovalhisleuasp
107010751080
argvalleu
1085
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<400>2
serthrileglugluglnalalysthrpheleuasplyspheasnhis
151015
glualagluaspleuphetyrglnserserleualasertrpasntyr
202530
asnthrasnilethrglugluasnvalglnasnmetasnasnalagly
354045
asplystrpseralapheleulysgluglnserthrleualaglnmet
505560
tyrproleuglngluileglnasnleuthrvallysleuglnleugln
65707580
alaleuglnglnasnglyserservalleusergluasplysserlys
859095
argleuasnthrileleuasnthrmetserthriletyrserthrgly
100105110
lysvalcysasnproaspasnproglnglucysleuleuleuglupro
115120125
glyleuasngluilemetalaasnserleuasptyrasngluargleu
130135140
trpalatrpglusertrpargsergluvalglylysglnleuargpro
145150155160
leutyrgluglutyrvalvalleulysasnglumetalaargalaasn
165170175
histyrgluasptyrglyasptyrtrpargglyasptyrgluvalasn
180185190
glyvalaspglytyrasptyrserargglyglnleuilegluaspval
195200205
gluhisthrpheglugluilelysproleutyrgluhisleuhisala
210215220
tyrvalargalalysleumetasnalatyrprosertyrileserpro
225230235240
ileglycysleuproalahisleuleuglyaspmettrpglyargphe
245250255
trpthrasnleutyrserleuthrvalpropheglyglnlysproasn
260265270
ileaspvalthraspalametvalaspglnalatrpaspalaglnarg
275280285
ilephelysglualaglulysphephevalservalglyleuproasn
290295300
metthrglnglyphetrpgluasnsermetleuthraspproglyasn
305310315320
valglnlysalavalcyshisprothralatrpaspleuglylysgly
325330335
asppheargileleumetcysthrlysvalthrmetaspasppheleu
340345350
thralahishisglumetglyhisileglntyraspmetalatyrala
355360365
alaglnpropheleuleuargasnglyalaasngluglyphehisglu
370375380
alavalglygluilemetserleuseralaalathrprolyshisleu
385390395400
lysserileglyleuleuserproasppheglngluaspasngluthr
405410415
gluileasnpheleuleulysglnalaleuthrilevalglythrleu
420425430
prophethrtyrmetleuglulystrpargtrpmetvalphelysgly
435440445
gluileprolysaspglntrpmetlyslystrptrpglumetlysarg
450455460
gluilevalglyvalvalgluprovalprohisaspgluthrtyrcys
465470475480
aspproalaserleuphehisvalserasnasptyrserpheilearg
485490495
tyrtyrthrargthrleutyrglnpheglnpheglnglualaleucys
500505510
glnalaalalyshisgluglyproleuhislyscysaspileserasn
515520525
serthrglualaglyglnlysleupheasnmetleuargleuglylys
530535540
sergluprotrpthrleualaleugluasnvalvalglyalalysasn
545550555560
metasnvalargproleuleuasntyrphegluproleuphethrtrp
565570575
leulysaspglnasnlysasnserphevalglytrpserthrasptrp
580585590
serprotyralaaspglnserilelysvalargileserleulysser
595600605
alaleuglyaspargalatyrglutrpasnaspasnglumettyrleu
610615620
pheargserservalalatyralametargglntyrpheleulysval
625630635640
lysasnglnmetileleupheglyglugluaspvalargvalalaasn
645650655
leulysproargileserpheasnphephevalthralaprolysasn
660665670
valseraspileileproargthrgluvalglulysalaileargmet
675680685
serargserargileasnaspalapheargleuasnaspasnserleu
690695700
glupheleuglyileglnprothrleuglyproproasnglnpropro
705710715720
valserglyserglyglyasplysthrhisthrcysproprocyspro
725730735
alaprogluleuleuglyglyproservalpheleupheproprolys
740745750
prolysaspthrleumetileserargthrprogluvalthrcysval
755760765
valvalaspvalserhisgluaspprogluvallyspheasntrptyr
770775780
valaspglyvalgluvalhisasnalalysthrlysproarggluglu
785790795800
glntyrasnserthrtyrargvalvalservalleuthrvalleuhis
805810815
glnasptrpleuasnglylysglutyrlyscyslysvalserasnlys
820825830
alaleuproalaproileglulysthrileserlysalalysglygln
835840845
proarggluproglnvaltyrthrleuproproserargaspgluleu
850855860
thrlysasnglnvalserleuthrcysleuvallysglyphetyrpro
865870875880
seraspilealavalglutrpgluserasnglyglnprogluasnasn
885890895
tyrlysthrthrproprovalleuaspseraspglyserphepheleu
900905910
tyrserlysleuthrvalasplysserargtrpglnglnglyasnval
915920925
phesercysservalmethisglualaleuhisasnhistyrthrgln
930935940
lysserleuserleuserproglylysproaspvaltyrleuleupro
945950955960
proalaarggluglnleuasnleuarggluseralathrilethrcys
965970975
leuvalthrglypheserproalaaspvalphevalglntrpmetgln
980985990
argglyglnproleuserproglulystyrvalthrseralapromet
99510001005
progluproglnalaproglyargtyrphealahisserileleu
101010151020
thrvalserglugluglutrpasnthrglygluthrtyrthrcys
102510301035
valvalalahisglualaleuproasnargvalthrgluargthr
104010451050
valasplysserthrglylysprothrleutyrasnvalserleu
105510601065
valmetseraspthralaglythrcystyrglyglyserglygly
107010751080
lysprolysglymetthrserserglntrpphelysileglnhis
108510901095
metglnproserproglnalacysasnseralametlysasnile
110011051110
asnlyshisthrlysargcyslysaspleuasnthrpheleuhis
111511201125
glupropheserservalalaalathrcysglnthrprolysile
113011351140
alacyslysasnglyasplysasncyshisglnserhisglyala
114511501155
valserleuthrmetcyslysleuthrserglylyshisproasn
116011651170
cysargtyrlysglulysargglnasnlyssertyrvalvalala
117511801185
cyslysproproglnlyslysaspserglnglnphehisleuval
119011951200
provalhisleuaspargvalleu
12051210
<210>3
<211>1104
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<220>
<223>fusionprotein
<400>3
metsersersersertrpleuleuleuserleuvalalavalthrala
151015
alaglnserthrileglugluglnalalysthrpheleuasplysphe
202530
asnhisglualagluaspleuphetyrglnserserleualasertrp
354045
asntyrasnthrasnilethrglugluasnvalglnasnmetasnasn
505560
alaglyasplystrpseralapheleulysgluglnserthrleuala
65707580
glnmettyrproleuglngluileglnasnleuthrvallysleugln
859095
leuglnalaleuglnglnasnglyserservalleusergluasplys
100105110
serlysargleuasnthrileleuasnthrmetserthriletyrser
115120125
thrglylysvalcysasnproaspasnproglnglucysleuleuleu
130135140
gluproglyleuasngluilemetalaasnserleuasptyrasnglu
145150155160
argleutrpalatrpglusertrpargsergluvalglylysglnleu
165170175
argproleutyrgluglutyrvalvalleulysasnglumetalaarg
180185190
alaasnhistyrgluasptyrglyasptyrtrpargglyasptyrglu
195200205
valasnglyvalaspglytyrasptyrserargglyglnleuileglu
210215220
aspvalgluhisthrpheglugluilelysproleutyrgluhisleu
225230235240
hisalatyrvalargalalysleumetasnalatyrprosertyrile
245250255
serproileglycysleuproalahisleuleuglyaspmettrpgly
260265270
argphetrpthrasnleutyrserleuthrvalpropheglyglnlys
275280285
proasnileaspvalthraspalametvalaspglnalatrpaspala
290295300
glnargilephelysglualaglulysphephevalservalglyleu
305310315320
proasnmetthrglnglyphetrpgluasnsermetleuthrasppro
325330335
glyasnvalglnlysalavalcyshisprothralatrpaspleugly
340345350
lysglyasppheargileleumetcysthrlysvalthrmetaspasp
355360365
pheleuthralahisaspglumetglyaspileglntyraspmetala
370375380
tyralaalaglnpropheleuleuargasnglyalaasngluglyphe
385390395400
hisglualavalglygluilemetserleuseralaalathrprolys
405410415
hisleulysserileglyleuleuserproasppheglngluaspasn
420425430
gluthrgluileasnpheleuleulysglnalaleuthrilevalgly
435440445
thrleuprophethrtyrmetleuglulystrpargtrpmetvalphe
450455460
lysglygluileprolysaspglntrpmetlyslystrptrpglumet
465470475480
lysarggluilevalglyvalvalgluprovalprohisaspgluthr
485490495
tyrcysaspproalaserleuphehisvalserasnasptyrserphe
500505510
ileargtyrtyrthrargthrleutyrglnpheglnpheglngluala
515520525
leucysglnalaalalyshisgluglyproleuhislyscysaspile
530535540
serasnserthrglualaglyglnlysleupheasnmetleuargleu
545550555560
glylyssergluprotrpthrleualaleugluasnvalvalglyala
565570575
lysasnmetasnvalargproleuleuasntyrphegluproleuphe
580585590
thrtrpleulysaspglnasnlysasnserphevalglytrpserthr
595600605
asptrpserprotyralaaspglnserilelysvalargileserleu
610615620
lysseralaleuglyaspargalatyrglutrpasnaspasnglumet
625630635640
tyrleupheargserservalalatyralametargglntyrpheleu
645650655
lysvallysasnglnmetileleupheglyglugluaspvalargval
660665670
alaasnleulysproargileserpheasnphephevalthralapro
675680685
lysasnvalseraspileileproargthrgluvalglulysalaile
690695700
argmetserargserargileasnaspalapheargleuasnaspasn
705710715720
serleuglupheleuglyileglnprothrleuglyproproasngln
725730735
proprovalserglyserglyglyasplysthrhisthrcyspropro
740745750
cysproalaprogluleuleuglyglyproservalpheleuphepro
755760765
prolysprolysaspthrleumetileserargthrprogluvalthr
770775780
cysvalvalvalaspvalserhisgluaspprogluvallyspheasn
785790795800
trptyrvalaspglyvalgluvalhisasnalalysthrlysproarg
805810815
glugluglntyrasnserthrtyrargvalvalservalleuthrval
820825830
leuhisglnasptrpleuasnglylysglutyrlyscyslysvalser
835840845
asnlysalaleuproalaproileglulysthrileserlysalalys
850855860
glyglnproarggluproglnvaltyrthrleuproproserargasp
865870875880
gluleuthrlysasnglnvalserleuthrcysleuvallysglyphe
885890895
tyrproseraspilealavalglutrpgluserasnglyglnproglu
900905910
asnasntyrlysthrthrproprovalleuaspseraspglyserphe
915920925
pheleutyrserlysleuthrvalasplysserargtrpglnglngly
930935940
asnvalphesercysservalmethisglualaleuhisasnhistyr
945950955960
thrglnlysserleuserleuserproglylysglyglyserglygly
965970975
lysprolysglymetthrserserglntrpphelysileglnhismet
980985990
glnproserproglnalacysasnseralametlysasnileasnlys
99510001005
histhrlysargcyslysaspleuasnthrpheleuhisglupro
101010151020
pheserservalalaalathrcysglnthrprolysilealacys
102510301035
lysasnglyasplysasncyshisglnserhisglyalavalser
104010451050
leuthrmetcyslysleuthrserglylyshisproasncysarg
105510601065
tyrlysglulysargglnasnlyssertyrvalvalalacyslys
107010751080
proproglnlyslysaspserglnglnphehisleuvalproval
108510901095
hisleuaspargvalleu
1100
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<223>fusionprotein
<400>4
metsersersersertrpleuleuleuserleuvalalavalthrala
151015
alaglnserthrileglugluglnalalysthrpheleuasplysphe
202530
asnhisglualagluaspleuphetyrglnserserleualasertrp
354045
asntyrasnthrasnilethrglugluasnvalglnasnmetasnasn
505560
alaglyasplystrpseralapheleulysgluglnserthrleuala
65707580
glnmettyrproleuglngluileglnasnleuthrvallysleugln
859095
leuglnalaleuglnglnasnglyserservalleusergluasplys
100105110
serlysargleuasnthrileleuasnthrmetserthriletyrser
115120125
thrglylysvalcysasnproaspasnproglnglucysleuleuleu
130135140
gluproglyleuasngluilemetalaasnserleuasptyrasnglu
145150155160
argleutrpalatrpglusertrpargsergluvalglylysglnleu
165170175
argproleutyrgluglutyrvalvalleulysasnglumetalaarg
180185190
alaasnhistyrgluasptyrglyasptyrtrpargglyasptyrglu
195200205
valasnglyvalaspglytyrasptyrserargglyglnleuileglu
210215220
aspvalgluhisthrpheglugluilelysproleutyrgluhisleu
225230235240
hisalatyrvalargalalysleumetasnalatyrprosertyrile
245250255
serproileglycysleuproalahisleuleuglyaspmettrpgly
260265270
argphetrpthrasnleutyrserleuthrvalpropheglyglnlys
275280285
proasnileaspvalthraspalametvalaspglnalatrpaspala
290295300
glnargilephelysglualaglulysphephevalservalglyleu
305310315320
proasnmetthrglnglyphetrpgluasnsermetleuthrasppro
325330335
glyasnvalglnlysalavalcyshisprothralatrpaspleugly
340345350
lysglyasppheargileleumetcysthrlysvalthrmetaspasp
355360365
pheleuthralahisaspglumetglyaspileglntyraspmetala
370375380
tyralaalaglnpropheleuleuargasnglyalaasngluglyphe
385390395400
hisglualavalglygluilemetserleuseralaalathrprolys
405410415
hisleulysserileglyleuleuserproasppheglngluaspasn
420425430
gluthrgluileasnpheleuleulysglnalaleuthrilevalgly
435440445
thrleuprophethrtyrmetleuglulystrpargtrpmetvalphe
450455460
lysglygluileprolysaspglntrpmetlyslystrptrpglumet
465470475480
lysarggluilevalglyvalvalgluprovalprohisaspgluthr
485490495
tyrcysaspproalaserleuphehisvalserasnasptyrserphe
500505510
ileargtyrtyrthrargthrleutyrglnpheglnpheglngluala
515520525
leucysglnalaalalyshisgluglyproleuhislyscysaspile
530535540
serasnserthrglualaglyglnlysleupheasnmetleuargleu
545550555560
glylyssergluprotrpthrleualaleugluasnvalvalglyala
565570575
lysasnmetasnvalargproleuleuasntyrphegluproleuphe
580585590
thrtrpleulysaspglnasnlysasnserphevalglytrpserthr
595600605
asptrpserprotyralaaspglnserilelysvalargileserleu
610615620
lysseralaleuglyaspargalatyrglutrpasnaspasnglumet
625630635640
tyrleupheargserservalalatyralametargglntyrpheleu
645650655
lysvallysasnglnmetileleupheglyglugluaspvalargval
660665670
alaasnleulysproargileserpheasnphephevalthralapro
675680685
lysasnvalseraspileileproargthrgluvalglulysalaile
690695700
argmetserargserargileasnaspalapheargleuasnaspasn
705710715720
serleuglupheleuglyileglnprothrleuglyproproasngln
725730735
proprovalserglyserglyglyasplysthrhisthrcyspropro
740745750
cysproalaprogluleuleuglyglyproservalpheleuphepro
755760765
prolysprolysaspthrleumetileserargthrprogluvalthr
770775780
cysvalvalvalaspvalserhisgluaspprogluvallyspheasn
785790795800
trptyrvalaspglyvalgluvalhisasnalalysthrlysproarg
805810815
glugluglntyrasnserthrtyrargvalvalservalleuthrval
820825830
leuhisglnasptrpleuasnglylysglutyrlyscyslysvalser
835840845
asnlysalaleuproalaproileglulysthrileserlysalalys
850855860
glyglnproarggluproglnvaltyrthrleuproproserargasp
865870875880
gluleuthrlysasnglnvalserleuthrcysleuvallysglyphe
885890895
tyrproseraspilealavalglutrpgluserasnglyglnproglu
900905910
asnasntyrlysthrthrproprovalleuaspseraspglyserphe
915920925
pheleutyrserlysleuthrvalasplysserargtrpglnglngly
930935940
asnvalphesercysservalmethisglualaleuhisasnhistyr
945950955960
thrglnlysserleuserleuserproglylysproaspvaltyrleu
965970975
leuproproalaarggluglnleuasnleuarggluseralathrile
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354045
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65707580
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130135140
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165170175
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180185190
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195200205
gluhisthrpheglugluilelysproleutyrgluhisleuhisala
210215220
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290295300
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610615620
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625630635640
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645650655
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850855860
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102510301035
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104010451050
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108510901095
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110011051110
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111511201125
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113011351140
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114511501155
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116011651170
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117511801185
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119011951200
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120512101215
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210215220
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245250255
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260265270
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305310315320
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340345350
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370375380
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405410415
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130135140
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145150155160
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195200205
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pheserservalalaalathrcysglnthrprolysilealacyslys
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290295300
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305310315320
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340345350
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245250255
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260265270
progluvallyspheasntrptyrvalaspglyvalgluvalhisasn
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325330335
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340345350
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355360365
cysleuvallysglyphetyrproseraspilealavalglutrpglu
370375380
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385390395400
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405410415
serargtrpglnglnglyasnvalphesercysservalmethisglu
420425430
alaleuhisasnhistyrthrglnlysserleuserleuserprogly
435440445
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450455460
arggluseralathrilethrcysleuvalthrglypheserproala
465470475480
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485490495
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500505510
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515520525
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151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serileasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
100105110
lysargthrvalalaalaproservalpheilepheproproserasp
115120125
gluglnleulysserglythralaservalvalcysleuleuasnasn
130135140
phetyrproargglualalysvalglntrplysvalaspasnalaleu
145150155160
glnserglyasnserglngluservalthrgluglnaspserlysasp
165170175
serthrtyrserleuserserthrleuthrleuserlysalaasptyr
180185190
glulyshislysvaltyralacysgluvalthrhisglnglyleuser
195200205
serprovalthrlysserpheasnargglyglucysglyglysergly
210215220
glylysprolysglymetthrserserglntrpphelysileglnhis
225230235240
metglnproserproglnalacysasnseralametlysasnileasn
245250255
lyshisthrlysargcyslysaspleuasnthrpheleuhisglupro
260265270
pheserservalalaalathrcysglnthrprolysilealacyslys
275280285
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290295300
metcyslysleuthrserglylyshisproasncysargtyrlysglu
305310315320
lysargglnasnlyssertyrvalvalalacyslysproproglnlys
325330335
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340345350
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glnmetglnleuvalglnserglythrgluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrglypheilethrtyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspsergluthrargtyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileasnthralatyr
65707580
leuglntrpserserleulysalaseraspthralailetyrtyrcys
859095
alaglyglyserglyileserthrprometaspvaltrpglyglngly
100105110
thrthrvalthrvalserseralaserthrlysglyproservalphe
115120125
proleualaproserserlysserthrserglyglythralaalaleu
130135140
glycysleuvallysasptyrpheprogluprovalthrvalsertrp
145150155160
asnserglyalaleuthrserglyvalhisthrpheproalavalleu
165170175
glnserserglyleutyrserleuserservalvalthrvalproser
180185190
serserleuglythrglnthrtyrilecysasnvalasnhislyspro
195200205
serasnthrlysvalasplysargvalgluprolyssercysasplys
210215220
thrhisthrcysproprocysproalaprogluleuleuglyglypro
225230235240
servalpheleupheproprolysprolysaspthrleumetileser
245250255
argthrprogluvalthrcysvalvalvalaspvalserhisgluasp
260265270
progluvallyspheasntrptyrvalaspglyvalgluvalhisasn
275280285
alalysthrlysproargglugluglntyrasnserthrtyrargval
290295300
valservalleuthrvalleuhisglnasptrpleuasnglylysglu
305310315320
tyrlyscyslysvalserasnlysalaleuproalaproileglulys
325330335
thrileserlysalalysglyglnproarggluproglnvaltyrthr
340345350
leuproproserarggluglumetthrlysasnglnvalserleuthr
355360365
cysleuvallysglyphetyrproseraspilealavalglutrpglu
370375380
serasnglyglnprogluasnasntyrlysthrthrproprovalleu
385390395400
aspseraspglyserphepheleutyrserlysleuthrvalasplys
405410415
serargtrpglnglnglyasnvalphesercysservalmethisglu
420425430
alaleuhisasnhistyrthrglnlysserleuserleuserprogly
435440445
lys
<210>12
<211>323
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>12
aspileglnleuthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serileasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
100105110
lysargthrvalalaalaproservalpheilepheproproserasp
115120125
gluglnleulysserglythralaservalvalcysleuleuasnasn
130135140
phetyrproargglualalysvalglntrplysvalaspasnalaleu
145150155160
glnserglyasnserglngluservalthrgluglnaspserlysasp
165170175
serthrtyrserleuserserthrleuthrleuserlysalaasptyr
180185190
glulyshislysvaltyralacysgluvalthrhisglnglyleuser
195200205
serprovalthrlysserpheasnargglyglucysglyglysergly
210215220
glymetalaserleuleucyscysglyprolysleualaalacysgly
225230235240
ilevalleuseralatrpglyvalilemetleuilemetleuglyile
245250255
phepheasnvalhisseralavalleuilegluaspvalprophethr
260265270
glulysaspphegluasnglyproglnasniletyrasnleutyrglu
275280285
glnvalsertyrasncyspheilealaalaglyleutyrleuleuleu
290295300
glyglypheserphecysglnvalargleuasnlysarglysglutyr
305310315320
metvalarg
<210>13
<211>574
<212>prt
<213>artificial
<220>
<223>fuisonprotein
<400>13
glnmetglnleuvalglnserglythrgluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrglypheilethrtyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspsergluthrargtyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileasnthralatyr
65707580
leuglntrpserserleulysalaseraspthralailetyrtyrcys
859095
alaglyglyserglyileserthrprometaspvaltrpglyglngly
100105110
thrthrvalthrvalserseralaserthrlysglyproservalphe
115120125
proleualaproserserlysserthrserglyglythralaalaleu
130135140
glycysleuvallysasptyrpheprogluprovalthrvalsertrp
145150155160
asnserglyalaleuthrserglyvalhisthrpheproalavalleu
165170175
glnserserglyleutyrserleuserservalvalthrvalproser
180185190
serserleuglythrglnthrtyrilecysasnvalasnhislyspro
195200205
serasnthrlysvalasplysargvalgluprolyssercysasplys
210215220
thrhisthrcysproprocysproalaprogluleuleuglyglypro
225230235240
servalpheleupheproprolysprolysaspthrleumetileser
245250255
argthrprogluvalthrcysvalvalvalaspvalserhisgluasp
260265270
progluvallyspheasntrptyrvalaspglyvalgluvalhisasn
275280285
alalysthrlysproargglugluglntyrasnserthrtyrargval
290295300
valservalleuthrvalleuhisglnasptrpleuasnglylysglu
305310315320
tyrlyscyslysvalserasnlysalaleuproalaproileglulys
325330335
thrileserlysalalysglyglnproarggluproglnvaltyrthr
340345350
leuproproserarggluglumetthrlysasnglnvalserleuthr
355360365
cysleuvallysglyphetyrproseraspilealavalglutrpglu
370375380
serasnglyglnprogluasnasntyrlysthrthrproprovalleu
385390395400
aspseraspglyserphepheleutyrserlysleuthrvalasplys
405410415
serargtrpglnglnglyasnvalphesercysservalmethisglu
420425430
alaleuhisasnhistyrthrglnlysserleuserleuserprogly
435440445
lysproaspvaltyrleuleuproproalaarggluglnleuasnleu
450455460
arggluseralathrilethrcysleuvalthrglypheserproala
465470475480
aspvalphevalglntrpmetglnargglyglnproleuserproglu
485490495
lystyrvalthrseralaprometprogluproglnalaproglyarg
500505510
tyrphealahisserileleuthrvalserglugluglutrpasnthr
515520525
glygluthrtyrthrcysvalvalalahisglualaleuproasnarg
530535540
valthrgluargthrvalasplysserthrglylysprothrleutyr
545550555560
asnvalserleuvalmetseraspthralaglythrcystyr
565570
<210>14
<211>323
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>14
aspileglnleuthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serileasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
100105110
lysargthrvalalaalaproservalpheilepheproproserasp
115120125
gluglnleulysserglythralaservalvalcysleuleuasnasn
130135140
phetyrproargglualalysvalglntrplysvalaspasnalaleu
145150155160
glnserglyasnserglngluservalthrgluglnaspserlysasp
165170175
serthrtyrserleuserserthrleuthrleuserlysalaasptyr
180185190
glulyshislysvaltyralacysgluvalthrhisglnglyleuser
195200205
serprovalthrlysserpheasnargglyglucysglyglysergly
210215220
glymetalaserleuleucyscysglyprolysleualaalacysgly
225230235240
ilevalleuseralatrpglyvalilemetleuilemetleuglyile
245250255
phepheasnvalhisseralavalleuilegluaspvalprophethr
260265270
glulysaspphegluasnglyproglnasniletyrasnleutyrglu
275280285
glnvalsertyrasncyspheilealaalaglyleutyrleuleuleu
290295300
glyglypheserphecysglnvalargleuasnlysarglysglutyr
305310315320
metvalarg
<210>15
<211>449
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>15
glnmetglnleuvalglnserglythrgluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrglypheilethrtyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspsergluthrargtyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileasnthralatyr
65707580
leuglntrpserserleulysalaseraspthralailetyrtyrcys
859095
alaglyglyserglyileserthrprometaspvaltrpglyglngly
100105110
thrthrvalthrvalserseralaserthrlysglyproservalphe
115120125
proleualaproserserlysserthrserglyglythralaalaleu
130135140
glycysleuvallysasptyrpheprogluprovalthrvalsertrp
145150155160
asnserglyalaleuthrserglyvalhisthrpheproalavalleu
165170175
glnserserglyleutyrserleuserservalvalthrvalproser
180185190
serserleuglythrglnthrtyrilecysasnvalasnhislyspro
195200205
serasnthrlysvalasplysargvalgluprolyssercysasplys
210215220
thrhisthrcysproprocysproalaprogluleuleuglyglypro
225230235240
servalpheleupheproprolysprolysaspthrleumetileser
245250255
argthrprogluvalthrcysvalvalvalaspvalserhisgluasp
260265270
progluvallyspheasntrptyrvalaspglyvalgluvalhisasn
275280285
alalysthrlysproargglugluglntyrasnserthrtyrargval
290295300
valservalleuthrvalleuhisglnasptrpleuasnglylysglu
305310315320
tyrlyscyslysvalserasnlysalaleuproalaproileglulys
325330335
thrileserlysalalysglyglnproarggluproglnvaltyrthr
340345350
leuproproserarggluglumetthrlysasnglnvalserleuthr
355360365
cysleuvallysglyphetyrproseraspilealavalglutrpglu
370375380
serasnglyglnprogluasnasntyrlysthrthrproprovalleu
385390395400
aspseraspglyserphepheleutyrserlysleuthrvalasplys
405410415
serargtrpglnglnglyasnvalphesercysservalmethisglu
420425430
alaleuhisasnhistyrthrglnlysserleuserleuserprogly
435440445
lys
<210>16
<211>389
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>16
aspileglnleuthrglnserproaspserleualavalserleugly
151015
gluargalathrileasncyslysserserglnservalleutyrser
202530
serileasnlysasntyrleualatrptyrglnglnlysproglygln
354045
proprolysleuleuiletyrtrpalaserthrarggluserglyval
505560
proaspargpheserglyserglyserglythraspphethrleuthr
65707580
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
859095
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
100105110
lysargthrvalalaalaproservalpheilepheproproserasp
115120125
gluglnleulysserglythralaservalvalcysleuleuasnasn
130135140
phetyrproargglualalysvalglntrplysvalaspasnalaleu
145150155160
glnserglyasnserglngluservalthrgluglnaspserlysasp
165170175
serthrtyrserleuserserthrleuthrleuserlysalaasptyr
180185190
glulyshislysvaltyralacysgluvalthrhisglnglyleuser
195200205
serprovalthrlysserpheasnargglyglucysglyglysergly
210215220
glymetargalatyrtrpproaspvalilehisserpheproasnarg
225230235240
serargphetrplyshisglutrpglulyshisglythrcysalaala
245250255
glnvalaspalaleuasnserglnlyslystyrpheglyargserleu
260265270
gluleutyrarggluleuaspleuasnservalleuleulysleugly
275280285
ilelysproserileasntyrtyrglnvalalaaspphelysaspala
290295300
leualaargvaltyrglyvalileprolysileglncysleupropro
305310315320
serglnaspglugluvalglnthrileglyglnilegluleucysleu
325330335
thrlysglnaspglnglnleuglnasncysthrgluproglyglugln
340345350
proserprolysglngluvaltrpleualaasnglyalaalagluser
355360365
argglyleuargvalcysgluaspglyprovalphetyrpropropro
370375380
lyslysthrlyshis
385
<210>17
<211>449
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>17
glnmetglnleuvalglnserglythrgluvallyslysproglyglu
151015
serleulysilesercyslysglyserglytyrglypheilethrtyr
202530
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
354045
glyileiletyrproglyaspsergluthrargtyrserproserphe
505560
glnglyglnvalthrileseralaasplysserileasnthralatyr
65707580
leuglntrpserserleulysalaseraspthralailetyrtyrcys
859095
alaglyglyserglyileserthrprometaspvaltrpglyglngly
100105110
thrthrvalthrvalserseralaserthrlysglyproservalphe
115120125
proleualaproserserlysserthrserglyglythralaalaleu
130135140
glycysleuvallysasptyrpheprogluprovalthrvalsertrp
145150155160
asnserglyalaleuthrserglyvalhisthrpheproalavalleu
165170175
glnserserglyleutyrserleuserservalvalthrvalproser
180185190
serserleuglythrglnthrtyrilecysasnvalasnhislyspro
195200205
serasnthrlysvalasplysargvalgluprolyssercysasplys
210215220
thrhisthrcysproprocysproalaprogluleuleuglyglypro
225230235240
servalpheleupheproprolysprolysaspthrleumetileser
245250255
argthrprogluvalthrcysvalvalvalaspvalserhisgluasp
260265270
progluvallyspheasntrptyrvalaspglyvalgluvalhisasn
275280285
alalysthrlysproargglugluglntyrasnserthrtyrargval
290295300
valservalleuthrvalleuhisglnasptrpleuasnglylysglu
305310315320
tyrlyscyslysvalserasnlysalaleuproalaproileglulys
325330335
thrileserlysalalysglyglnproarggluproglnvaltyrthr
340345350
leuproproserarggluglumetthrlysasnglnvalserleuthr
355360365
cysleuvallysglyphetyrproseraspilealavalglutrpglu
370375380
serasnglyglnprogluasnasntyrlysthrthrproprovalleu
385390395400
aspseraspglyserphepheleutyrserlysleuthrvalasplys
405410415
serargtrpglnglnglyasnvalphesercysservalmethisglu
420425430
alaleuhisasnhistyrthrglnlysserleuserleuserprogly
435440445
lys
<210>18
<211>363
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>18
serleuhisvallysproproglnphethrtrpalaglntrppheglu
151015
thrglnhisileasnmetthrserglnglncysthrasnalametgln
202530
valileasnasntyrglnargargcyslysasnglnasnthrpheleu
354045
leuthrthrphealaasnvalvalasnvalcysglyasnproasnmet
505560
thrcysproserasnlysthrarglysasncyshishisserglyser
65707580
glnvalproleuilehiscysasnleuthrthrproserproglnasn
859095
ileserasncysargtyralaglnthrproalaasnmetphetyrile
100105110
valalacysaspasnargaspglnargargaspproproglntyrpro
115120125
valvalprovalhisleuaspargileileglyglyserglyglyasp
130135140
ileglnleuthrglnserproaspserleualavalserleuglyglu
145150155160
argalathrileasncyslysserserglnservalleutyrserser
165170175
ileasnlysasntyrleualatrptyrglnglnlysproglyglnpro
180185190
prolysleuleuiletyrtrpalaserthrarggluserglyvalpro
195200205
aspargpheserglyserglyserglythraspphethrleuthrile
210215220
serserleuglnalagluaspvalalavaltyrtyrcysglnglntyr
225230235240
tyrserthrprotyrthrpheglyglnglythrlysvalgluilelys
245250255
argthrvalalaalaproservalpheilepheproproseraspglu
260265270
glnleulysserglythralaservalvalcysleuleuasnasnphe
275280285
tyrproargglualalysvalglntrplysvalaspasnalaleugln
290295300
serglyasnserglngluservalthrgluglnaspserlysaspser
305310315320
thrtyrserleuserserthrleuthrleuserlysalaasptyrglu
325330335
lyshislysvaltyralacysgluvalthrhisglnglyleuserser
340345350
provalthrlysserpheasnargglyglucys
355360
<210>19
<211>1009
<212>prt
<213>artificial
<220>
<223>fusionprotein
<400>19
metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglylysvalcysasnproaspasnproglnglucysleuleu
115120125
leugluproglyleuasngluilemetalaasnserleuasptyrasn
130135140
gluargleutrpalatrpglusertrpargsergluvalglylysgln
145150155160
leuargproleutyrgluglutyrvalvalleulysasnglumetala
165170175
argalaasnhistyrgluasptyrglyasptyrtrpargglyasptyr
180185190
gluvalasnglyvalaspglytyrasptyrserargglyglnleuile
195200205
gluaspvalgluhisthrpheglugluilelysproleutyrgluhis
210215220
leuhisalatyrvalargalalysleumetasnalatyrprosertyr
225230235240
ileserproileglycysleuproalahisleuleuglyaspmettrp
245250255
glyargphetrpthrasnleutyrserleuthrvalpropheglygln
260265270
lysproasnileaspvalthraspalametvalaspglnalatrpasp
275280285
alaglnargilephelysglualaglulysphephevalservalgly
290295300
leuproasnmetthrglnglyphetrpgluasnsermetleuthrasp
305310315320
proglyasnvalglnlysalavalcyshisprothralatrpaspleu
325330335
glylysglyasppheargileleuglyglyglyglyserglyglygly
340345350
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
355360365
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
370375380
glyglyglyglyseraspileglnleuthrglnserproaspserleu
385390395400
alavalserleuglygluargalathrileasncyslyssersergln
405410415
servalleutyrserserileasnlysasntyrleualatrptyrgln
420425430
glnlysproglyglnproprolysleuleuiletyrtrpalaserthr
435440445
arggluserglyvalproaspargpheserglyserglyserglythr
450455460
aspphethrleuthrileserserleuglnalagluaspvalalaval
465470475480
tyrtyrcysglnglntyrtyrserthrprotyrthrpheglyglngly
485490495
thrlysvalgluilelysargglyglyserglyglyglyglysergly
500505510
glyglyserglyglyglyserglyglyserglyglnmetglnleuval
515520525
glnserglythrgluvallyslysproglygluserleulysileser
530535540
cyslysglyserglytyrglypheilethrtyrtrpileglytrpval
545550555560
argglnmetproglylysglyleuglutrpmetglyileiletyrpro
565570575
glyaspsergluthrargtyrserproserpheglnglyglnvalthr
580585590
ileseralaasplysserileasnthralatyrleuglntrpserser
595600605
leulysalaseraspthralailetyrtyrcysalaglyglysergly
610615620
ileserthrprometaspvaltrpglyglnglythrthrvalthrval
625630635640
serserglyglyglyserglyglyasplysthrhisthrcyspropro
645650655
cysproalaprogluleuleuglyglyproservalpheleuphepro
660665670
prolysprolysaspthrleumetileserargthrprogluvalthr
675680685
cysvalvalvalaspvalserhisgluaspprogluvallyspheasn
690695700
trptyrvalaspglyvalgluvalhisasnalalysthrlysproarg
705710715720
glugluglntyrasnserthrtyrargvalvalservalleuthrval
725730735
leuhisglnasptrpleuasnglylysglutyrlyscyslysvalser
740745750
asnlysalaleuproalaproileglulysthrileserlysalalys
755760765
glyglnproarggluproglnvaltyrthrleuproproserargasp
770775780
gluleuthrlysasnglnvalserleuthrcysleuvallysglyphe
785790795800
tyrproseraspilealavalglutrpgluserasnglyglnproglu
805810815
asnasntyrlysthrthrproprovalleuaspseraspglyserphe
820825830
pheleutyrserlysleuthrvalasplysserargtrpglnglngly
835840845
asnvalphesercysservalmethisglualaleuhisasnhistyr
850855860
thrglnlysserleuserleuserproglylysglyglyserglygly
865870875880
glylysprolysglymetthrserserglntrpphelysileglnhis
885890895
metglnproserproglnalacysasnseralametlysasnileasn
900905910
lyshisthrlysargcyslysaspleuasnthrpheleuhisglupro
915920925
pheserservalalaalathrcysglnthrprolysilealacyslys
930935940
asnglyasplysasncyshisglnserhisglyalavalserleuthr
945950955960
metcyslysleuthrserglylyshisproasncysargtyrlysglu
965970975
lysargglnasnlyssertyrvalvalalacyslysproproglnlys
980985990
lysaspserglnglnphehisleuvalprovalhisleuaspargval
99510001005
leu
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metglyserserthrileglugluglnalalysthrpheleuaspleu
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglylysvalcysasnproaspasnproglnglucysleuleu
115120125
leugluproglyleuasngluilemetalaasnserleuasptyrasn
130135140
gluargleutrpalatrpglusertrpargsergluvalglylysgln
145150155160
leuargproleutyrgluglutyrvalvalleulysasnglumetala
165170175
argalaasnhistyrgluasptyrglyasptyrtrpargglyasptyr
180185190
gluvalasnglyvalaspglytyrasptyrserargglyglnleuile
195200205
gluaspvalgluhisthrpheglugluilelysproleutyrgluhis
210215220
leuhisalatyrvalargalalysleumetasnalatyrprosertyr
225230235240
ileserproileglycysleuproalahisleuleuglyaspmettrp
245250255
glyargphetrpthrasnleutyrserleuthrvalpropheglygln
260265270
lysproasnileaspvalthraspalametvalaspglnalatrpasp
275280285
alaglnargilephelysglualaglulysphephevalservalgly
290295300
leuproasnmetthrglnglyphetrpgluasnsermetleuthrasp
305310315320
proglyasnvalglnlysalavalcyshisprothralatrpaspleu
325330335
glylysglyasppheargileleuglyglyglyglyserglyglygly
340345350
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
355360365
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
370375380
glyglyglyglyseraspileglnleuthrglnserproaspserleu
385390395400
alavalserleuglygluargalathrileasncyslyssersergln
405410415
servalleutyrserserileasnlysasntyrleualatrptyrgln
420425430
glnlysproglyglnproprolysleuleuiletyrtrpalaserthr
435440445
arggluserglyvalproaspargpheserglyserglyserglythr
450455460
aspphethrleuthrileserserleuglnalagluaspvalalaval
465470475480
tyrtyrcysglnglntyrtyrserthrprotyrthrpheglyglngly
485490495
thrlysvalgluilelysargglyglyserglyglyglyglysergly
500505510
glyglyserglyglyglyserglyglyserglyglnmetglnleuval
515520525
glnserglythrgluvallyslysproglygluserleulysileser
530535540
cyslysglyserglytyrglypheilethrtyrtrpileglytrpval
545550555560
argglnmetproglylysglyleuglutrpmetglyileiletyrpro
565570575
glyaspsergluthrargtyrserproserpheglnglyglnvalthr
580585590
ileseralaasplysserileasnthralatyrleuglntrpserser
595600605
leulysalaseraspthralailetyrtyrcysalaglyglysergly
610615620
ileserthrprometaspvaltrpglyglnglythrthrvalthrval
625630635640
serserglyglyglyserglyglyasplysthrhisthrcyspropro
645650655
cysproalaprogluleuleuglyglyproservalpheleuphepro
660665670
prolysprolysaspthrleumetileserargthrprogluvalthr
675680685
cysvalvalvalaspvalserhisgluaspprogluvallyspheasn
690695700
trptyrvalaspglyvalgluvalhisasnalalysthrlysproarg
705710715720
glugluglntyrasnserthrtyrargvalvalservalleuthrval
725730735
leuhisglnasptrpleuasnglylysglutyrlyscyslysvalser
740745750
asnlysalaleuproalaproileglulysthrileserlysalalys
755760765
glyglnproarggluproglnvaltyrthrleuproproserargasp
770775780
gluleuthrlysasnglnvalserleuthrcysleuvallysglyphe
785790795800
tyrproseraspilealavalglutrpgluserasnglyglnproglu
805810815
asnasntyrlysthrthrproprovalleuaspseraspglyserphe
820825830
pheleutyrserlysleuthrvalasplysserargtrpglnglngly
835840845
asnvalphesercysservalmethisglualaleuhisasnhistyr
850855860
thrglnlysserleuserleuserproglylysglyglyserglygly
865870875880
glylysprolysglymetthrserserglntrpphelysileglnhis
885890895
metglnproserproglnalacysasnseralametlysasnileasn
900905910
lyshisthrlysargcyslysaspleuasnthrpheleuhisglupro
915920925
pheserservalalaalathrcysglnthrprolysilealacyslys
930935940
asnglyasplysasncyshisglnserhisglyalavalserleuthr
945950955960
metcyslysleuthrserglylyshisproasncysargtyrlysglu
965970975
lysargglnasnlyssertyrvalvalalacyslysproproglnlys
980985990
lysaspserglnglnphehisleuvalprovalhisleuaspargval
99510001005
leu
<210>21
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metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglylysvalcysasnproaspasnproglnglucysleuleu
115120125
leugluproglyleuasngluilemetalaasnserleuasptyrasn
130135140
gluargleutrpalatrpglusertrpargsergluvalglylysgln
145150155160
leuargproleutyrgluglutyrvalvalleulysasnglumetala
165170175
argalaasnhistyrgluasptyrglyasptyrtrpargglyasptyr
180185190
gluvalasnglyvalaspglytyrasptyrserargglyglnleuile
195200205
gluaspvalgluhisthrpheglugluilelysproleutyrgluhis
210215220
leuhisalatyrvalargalalysleumetasnalatyrprosertyr
225230235240
ileserproileglycysleuproalahisleuleuglyaspmettrp
245250255
glyargphetrpthrasnleutyrserleuthrvalpropheglygln
260265270
lysproasnileaspvalthraspalametvalaspglnalatrpasp
275280285
alaglnargilephelysglualaglulysphephevalservalgly
290295300
leuproasnmetthrglnglyphetrpgluasnsermetleuthrasp
305310315320
proglyasnvalglnlysalavalcyshisprothralatrpaspleu
325330335
glylysglyasppheargileleuglyglyglyglyserglyglygly
340345350
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
355360365
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
370375380
glyglyglyglyserglnmetglnleuvalglnserglythrgluval
385390395400
lyslysproglygluserleulysilesercyslysglyserglytyr
405410415
glypheilethrtyrtrpileglytrpvalargglnmetproglylys
420425430
glyleuglutrpmetglyileiletyrproglyaspsergluthrarg
435440445
tyrserproserpheglnglyglnvalthrileseralaasplysser
450455460
ileasnthralatyrleuglntrpserserleulysalaseraspthr
465470475480
alailetyrtyrcysalaglyglyserglyileserthrprometasp
485490495
valtrpglyglnglythrthrvalthrvalserserglyglysergly
500505510
glyglyglyserglyglyglyserglyglyglyserglyglysergly
515520525
aspileglnleuthrglnserproaspserleualavalserleugly
530535540
gluargalathrileasncyslysserserglnservalleutyrser
545550555560
serileasnlysasntyrleualatrptyrglnglnlysproglygln
565570575
proprolysleuleuiletyrtrpalaserthrarggluserglyval
580585590
proaspargpheserglyserglyserglythraspphethrleuthr
595600605
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
610615620
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
625630635640
lysargglyglyglyglyserglyglyglyglyserglyglyglygly
645650655
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
660665670
glyglyglyglyserglyglyglyglyserglyglyglyglyserala
675680685
alaglythrvalphethrthrvalgluaspleuglyserlysileleu
690695700
leuthrcysserleuasnaspseralathrgluvalthrglyhisarg
705710715720
trpleulysglyglyvalvalleulysgluaspalaleuproglygln
725730735
lysthrgluphelysvalaspseraspaspglntrpglyglutyrser
740745750
cysvalpheleuprogluprometglythralaasnileglnleuhis
755760765
glyproproargvallysalavallyssersergluhisileasnglu
770775780
glygluthralametleuvalcyslyssergluservalproproval
785790795800
thrasptrpalatrptyrlysilethraspsergluasplysalaleu
805810815
metasnglysergluserargphephevalserserserglnglyarg
820825830
sergluleuhisilegluasnleuasnmetglualaaspproglygln
835840845
tyrargcysasnglythrserserlysglyseraspglnalaileile
850855860
thrleuargvalargserhisleualaalaleutrpproleuleugly
865870875880
ilevalalagluvalleuvalleuvalthrileilepheiletyrglu
885890895
lysargarglysprogluaspvalleuaspaspaspaspalaglyser
900905910
alaproleulysserserglyglnhisglnasnasplysglylysasn
915920925
valargglnargasnserserglyglyglyserglyglyglysergly
930935940
glyglyasplysthrhisthrcysproprocysproalaprogluleu
945950955960
leuglyglyproservalpheleupheproprolysprolysaspthr
965970975
leumetileserargthrprogluvalthrcysvalvalvalaspval
980985990
serhisgluaspprogluvallyspheasntrptyrvalaspglyval
99510001005
gluvalhisasnalalysthrlysproargglugluglntyrasn
101010151020
serthrtyrargvalvalservalleuthrvalleuhisglnasp
102510301035
trpleuasnglylysglutyrlyscyslysvalserasnlysala
104010451050
leuproalaproileglulysthrileserlysalalysglygln
105510601065
proarggluproglnvaltyrthrleuproproserargaspglu
107010751080
leuthrlysasnglnvalserleuthrcysleuvallysglyphe
108510901095
tyrproseraspilealavalglutrpgluserasnglyglnpro
110011051110
gluasnasntyrlysthrthrproprovalleuaspseraspgly
111511201125
serphepheleutyrserlysleuthrvalasplysserargtrp
113011351140
glnglnglyasnvalphesercysservalmethisglualaleu
114511501155
hisasnhistyrthrglnlysserleuserleuserproglylys
116011651170
glyglyserglyglyserleuhisvallysproproglnphethr
117511801185
trpalaglntrpphegluthrglnhisileasnmetthrsergln
119011951200
glncysthrasnalametglnvalileasnasntyrglnargarg
120512101215
cyslysasnglnasnthrpheleuleuthrthrphealaasnval
122012251230
valasnvalcysglyasnproasnmetthrcysproserasnlys
123512401245
thrarglysasncyshishisserglyserglnvalproleuile
125012551260
hiscysasnleuthrthrproserproglnasnileserasncys
126512701275
argtyralaglnthrproalaasnmetphetyrilevalalacys
128012851290
aspasnargaspglnargargaspproproglntyrprovalval
129513001305
provalhisleuaspargileile
13101315
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<400>22
metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnpheglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglylysvalcysasnproaspasnproglnglucysleuleu
115120125
leugluproglyleuasngluilemetalaasnserleuasptyrasn
130135140
gluargleutrpalatrpglusertrpargsergluvalglylysgln
145150155160
leuargproleutyrgluglutyrvalvalleulysasnglumetala
165170175
argalaasnhistyrgluasptyrglyasptyrtrpargglyasptyr
180185190
gluvalasnglyvalaspglytyrasptyrserargglyglnleuile
195200205
gluaspvalgluhisthrpheglugluilelysproleutyrgluhis
210215220
leuhisalatyrvalargalalysleumetasnalatyrprosertyr
225230235240
ileserproileglycysleuproalahisleuleuglyaspmettrp
245250255
glyargphetrpthrasnleutyrserleuthrvalpropheglygln
260265270
lysproasnileaspvalthraspalametvalaspglnalatrpasp
275280285
alaglnargilephelysglualaglulysphephevalservalgly
290295300
leuproasnmetthrglnglyphetrpgluasnsermetleuthrasp
305310315320
proglyasnvalglnlysalavalcyshisprothralatrpaspleu
325330335
glylysglyasppheargileleuglyglyglyglyserglyglygly
340345350
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
355360365
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
370375380
glyglyglyglyserglnmetglnleuvalglnserglythrgluval
385390395400
lyslysproglygluserleulysilesercyslysglyserglytyr
405410415
glypheilethrtyrtrpileglytrpvalargglnmetproglylys
420425430
glyleuglutrpmetglyileiletyrproglyaspsergluthrarg
435440445
tyrserproserpheglnglyglnvalthrileseralaasplysser
450455460
ileasnthralatyrleuglntrpserserleulysalaseraspthr
465470475480
alailetyrtyrcysalaglyglyserglyileserthrprometasp
485490495
valtrpglyglnglythrthrvalthrvalserserglyglysergly
500505510
glyglyglyserglyglyglyserglyglyglyserglyglysergly
515520525
aspileglnleuthrglnserproaspserleualavalserleugly
530535540
gluargalathrileasncyslysserserglnservalleutyrser
545550555560
serileasnlysasntyrleualatrptyrglnglnlysproglygln
565570575
proprolysleuleuiletyrtrpalaserthrarggluserglyval
580585590
proaspargpheserglyserglyserglythraspphethrleuthr
595600605
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
610615620
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
625630635640
lysargglyglyglyglyserglyglyglyglyserglyglyglygly
645650655
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
660665670
glyglyglyglyserglyglyglyglyserglyglyglyglyserala
675680685
alaglythrvalphethrthrvalgluaspleuglyserlysileleu
690695700
leuthrcysserleuasnaspseralathrgluvalthrglyhisarg
705710715720
trpleulysglyglyvalvalleulysgluaspalaleuproglygln
725730735
lysthrgluphelysvalaspseraspaspglntrpglyglutyrser
740745750
cysvalpheleuprogluprometglythralaasnileglnleuhis
755760765
glyproproargvallysalavallyssersergluhisileasnglu
770775780
glygluthralametleuvalcyslyssergluservalproproval
785790795800
thrasptrpalatrptyrlysilethraspsergluasplysalaleu
805810815
metasnglysergluserargphephevalserserserglnglyarg
820825830
sergluleuhisilegluasnleuasnmetglualaaspproglygln
835840845
tyrargcysasnglythrserserlysglyseraspglnalaileile
850855860
thrleuargvalargserhisleualaalaleutrpproleuleugly
865870875880
ilevalalagluvalleuvalleuvalthrileilepheiletyrglu
885890895
lysargarglysprogluaspvalleuaspaspaspaspalaglyser
900905910
alaproleulysserserglyglnhisglnasnasplysglylysasn
915920925
valargglnargasnserserglyglyglyserglyglyglysergly
930935940
glyglyasplysthrhisthrcysproprocysproalaprogluleu
945950955960
leuglyglyproservalpheleupheproprolysprolysaspthr
965970975
leumetileserargthrprogluvalthrcysvalvalvalaspval
980985990
serhisgluaspprogluvallyspheasntrptyrvalaspglyval
99510001005
gluvalhisasnalalysthrlysproargglugluglntyrasn
101010151020
serthrtyrargvalvalservalleuthrvalleuhisglnasp
102510301035
trpleuasnglylysglutyrlyscyslysvalserasnlysala
104010451050
leuproalaproileglulysthrileserlysalalysglygln
105510601065
proarggluproglnvaltyrthrleuproproserargaspglu
107010751080
leuthrlysasnglnvalserleuthrcysleuvallysglyphe
108510901095
tyrproseraspilealavalglutrpgluserasnglyglnpro
110011051110
gluasnasntyrlysthrthrproprovalleuaspseraspgly
111511201125
serphepheleutyrserlysleuthrvalasplysserargtrp
113011351140
glnglnglyasnvalphesercysservalmethisglualaleu
114511501155
hisasnhistyrthrglnlysserleuserleuserproglylys
116011651170
glyglyserglyglyserleuhisvallysproproglnphethr
117511801185
trpalaglntrpphegluthrglnhisileasnmetthrsergln
119011951200
glncysthrasnalametglnvalileasnasntyrglnargarg
120512101215
cyslysasnglnasnthrpheleuleuthrthrphealaasnval
122012251230
valasnvalcysglyasnproasnmetthrcysproserasnlys
123512401245
thrarglysasncyshishisserglyserglnvalproleuile
125012551260
hiscysasnleuthrthrproserproglnasnileserasncys
126512701275
argtyralaglnthrproalaasnmetphetyrilevalalacys
128012851290
aspasnargaspglnargargaspproproglntyrprovalval
129513001305
provalhisleuaspargileile
13101315
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metglyserserthrileglugluglnalalysthrpheleuaspleu
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
aspileglnleuthrglnserproaspserleualavalserleugly
165170175
gluargalathrileasncyslysserserglnservalleutyrser
180185190
serileasnlysasntyrleualatrptyrglnglnlysproglygln
195200205
proprolysleuleuiletyrtrpalaserthrarggluserglyval
210215220
proaspargpheserglyserglyserglythraspphethrleuthr
225230235240
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
245250255
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
260265270
lysargglyglyserglyglyglyglyserglyglyglyserglygly
275280285
glyserglyglyserglyglnmetglnleuvalglnserglythrglu
290295300
vallyslysproglygluserleulysilesercyslysglysergly
305310315320
tyrglypheilethrtyrtrpileglytrpvalargglnmetprogly
325330335
lysglyleuglutrpmetglyileiletyrproglyaspsergluthr
340345350
argtyrserproserpheglnglyglnvalthrileseralaasplys
355360365
serileasnthralatyrleuglntrpserserleulysalaserasp
370375380
thralailetyrtyrcysalaglyglyserglyileserthrpromet
385390395400
aspvaltrpglyglnglythrthrvalthrvalserserglyglygly
405410415
serglyglyasplysthrhisthrcysproprocysproalaproglu
420425430
leuleuglyglyproservalpheleupheproprolysprolysasp
435440445
thrleumetileserargthrprogluvalthrcysvalvalvalasp
450455460
valserhisgluaspprogluvallyspheasntrptyrvalaspgly
465470475480
valgluvalhisasnalalysthrlysproargglugluglntyrasn
485490495
serthrtyrargvalvalservalleuthrvalleuhisglnasptrp
500505510
leuasnglylysglutyrlyscyslysvalserasnlysalaleupro
515520525
alaproileglulysthrileserlysalalysglyglnproargglu
530535540
proglnvaltyrthrleuproproserargaspgluleuthrlysasn
545550555560
glnvalserleuthrcysleuvallysglyphetyrproseraspile
565570575
alavalglutrpgluserasnglyglnprogluasnasntyrlysthr
580585590
thrproprovalleuaspseraspglyserphepheleutyrserlys
595600605
leuthrvalasplysserargtrpglnglnglyasnvalphesercys
610615620
servalmethisglualaleuhisasnhistyrthrglnlysserleu
625630635640
serleuserproglylysglyglyserglyglylysprolysglymet
645650655
thrserserglntrpphelysileglnhismetglnproserprogln
660665670
alacysasnseralametlysasnileasnlyshisthrlysargcys
675680685
lysaspleuasnthrpheleuhisglupropheserservalalaala
690695700
thrcysglnthrprolysilealacyslysasnglyasplysasncys
705710715720
hisglnserhisglyalavalserleuthrmetcyslysleuthrser
725730735
glylyshisproasncysargtyrlysglulysargglnasnlysser
740745750
tyrvalvalalacyslysproproglnlyslysaspserglnglnphe
755760765
hisleuvalprovalhisleuaspargvalleu
770775
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metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
aspileglnleuthrglnserproaspserleualavalserleugly
165170175
gluargalathrileasncyslysserserglnservalleutyrser
180185190
serileasnlysasntyrleualatrptyrglnglnlysproglygln
195200205
proprolysleuleuiletyrtrpalaserthrarggluserglyval
210215220
proaspargpheserglyserglyserglythraspphethrleuthr
225230235240
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
245250255
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
260265270
lysargglyglyserglyglyglyglyserglyglyglyserglygly
275280285
glyserglyglyserglyglnmetglnleuvalglnserglythrglu
290295300
vallyslysproglygluserleulysilesercyslysglysergly
305310315320
tyrglypheilethrtyrtrpileglytrpvalargglnmetprogly
325330335
lysglyleuglutrpmetglyileiletyrproglyaspsergluthr
340345350
argtyrserproserpheglnglyglnvalthrileseralaasplys
355360365
serileasnthralatyrleuglntrpserserleulysalaserasp
370375380
thralailetyrtyrcysalaglyglyserglyileserthrpromet
385390395400
aspvaltrpglyglnglythrthrvalthrvalserserglyglygly
405410415
serglyglyasplysthrhisthrcysproprocysproalaproglu
420425430
leuleuglyglyproservalpheleupheproprolysprolysasp
435440445
thrleumetileserargthrprogluvalthrcysvalvalvalasp
450455460
valserhisgluaspprogluvallyspheasntrptyrvalaspgly
465470475480
valgluvalhisasnalalysthrlysproargglugluglntyrasn
485490495
serthrtyrargvalvalservalleuthrvalleuhisglnasptrp
500505510
leuasnglylysglutyrlyscyslysvalserasnlysalaleupro
515520525
alaproileglulysthrileserlysalalysglyglnproargglu
530535540
proglnvaltyrthrleuproproserargaspgluleuthrlysasn
545550555560
glnvalserleuthrcysleuvallysglyphetyrproseraspile
565570575
alavalglutrpgluserasnglyglnprogluasnasntyrlysthr
580585590
thrproprovalleuaspseraspglyserphepheleutyrserlys
595600605
leuthrvalasplysserargtrpglnglnglyasnvalphesercys
610615620
servalmethisglualaleuhisasnhistyrthrglnlysserleu
625630635640
serleuserproglylysglyglyserglyglylysprolysglymet
645650655
thrserserglntrpphelysileglnhismetglnproserprogln
660665670
alacysasnseralametlysasnileasnlyshisthrlysargcys
675680685
lysaspleuasnthrpheleuhisglupropheserservalalaala
690695700
thrcysglnthrprolysilealacyslysasnglyasplysasncys
705710715720
hisglnserhisglyalavalserleuthrmetcyslysleuthrser
725730735
glylyshisproasncysargtyrlysglulysargglnasnlysser
740745750
tyrvalvalalacyslysproproglnlyslysaspserglnglnphe
755760765
hisleuvalprovalhisleuaspargvalleu
770775
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metglyserserthrileglugluglnalalysthrpheleuaspleu
151015
pheasnpheglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
aspileglnleuthrglnserproaspserleualavalserleugly
165170175
gluargalathrileasncyslysserserglnservalleutyrser
180185190
serileasnlysasntyrleualatrptyrglnglnlysproglygln
195200205
proprolysleuleuiletyrtrpalaserthrarggluserglyval
210215220
proaspargpheserglyserglyserglythraspphethrleuthr
225230235240
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
245250255
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
260265270
lysargglyglyserglyglyglyglyserglyglyglyserglygly
275280285
glyserglyglyserglyglnmetglnleuvalglnserglythrglu
290295300
vallyslysproglygluserleulysilesercyslysglysergly
305310315320
tyrglypheilethrtyrtrpileglytrpvalargglnmetprogly
325330335
lysglyleuglutrpmetglyileiletyrproglyaspsergluthr
340345350
argtyrserproserpheglnglyglnvalthrileseralaasplys
355360365
serileasnthralatyrleuglntrpserserleulysalaserasp
370375380
thralailetyrtyrcysalaglyglyserglyileserthrpromet
385390395400
aspvaltrpglyglnglythrthrvalthrvalserserglyglygly
405410415
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
420425430
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
435440445
glyglyglyglyserglyglyglyglyseralaalaglythrvalphe
450455460
thrthrvalgluaspleuglyserlysileleuleuthrcysserleu
465470475480
asnaspseralathrgluvalthrglyhisargtrpleulysglygly
485490495
valvalleulysgluaspalaleuproglyglnlysthrgluphelys
500505510
valaspseraspaspglntrpglyglutyrsercysvalpheleupro
515520525
gluprometglythralaasnileglnleuhisglyproproargval
530535540
lysalavallyssersergluhisileasngluglygluthralamet
545550555560
leuvalcyslyssergluservalproprovalthrasptrpalatrp
565570575
tyrlysilethraspsergluasplysalaleumetasnglyserglu
580585590
serargphephevalserserserglnglyargsergluleuhisile
595600605
gluasnleuasnmetglualaaspproglyglntyrargcysasngly
610615620
thrserserlysglyseraspglnalaileilethrleuargvalarg
625630635640
serhisleualaalaleutrpproleuleuglyilevalalagluval
645650655
leuvalleuvalthrileilepheiletyrglulysargarglyspro
660665670
gluaspvalleuaspaspaspaspalaglyseralaproleulysser
675680685
serglyglnhisglnasnasplysglylysasnvalargglnargasn
690695700
serserglyglyglyserglyglyglyserglyglyglyasplysthr
705710715720
histhrcysproprocysproalaprogluleuleuglyglyproser
725730735
valpheleupheproprolysprolysaspthrleumetileserarg
740745750
thrprogluvalthrcysvalvalvalaspvalserhisgluasppro
755760765
gluvallyspheasntrptyrvalaspglyvalgluvalhisasnala
770775780
lysthrlysproargglugluglntyrasnserthrtyrargvalval
785790795800
servalleuthrvalleuhisglnasptrpleuasnglylysglutyr
805810815
lyscyslysvalserasnlysalaleuproalaproileglulysthr
820825830
ileserlysalalysglyglnproarggluproglnvaltyrthrleu
835840845
proproserargaspgluleuthrlysasnglnvalserleuthrcys
850855860
leuvallysglyphetyrproseraspilealavalglutrpgluser
865870875880
asnglyglnprogluasnasntyrlysthrthrproprovalleuasp
885890895
seraspglyserphepheleutyrserlysleuthrvalasplysser
900905910
argtrpglnglnglyasnvalphesercysservalmethisgluala
915920925
leuhisasnhistyrthrglnlysserleuserleuserproglylys
930935940
glyglyserglyglylysprolysglymetthrserserglntrpphe
945950955960
lysileglnhismetglnproserproglnalacysasnseralamet
965970975
lysasnileasnlyshisthrlysargcyslysaspleuasnthrphe
980985990
leuhisglupropheserservalalaalathrcysglnthrprolys
99510001005
ilealacyslysasnglyasplysasncyshisglnserhisgly
101010151020
alavalserleuthrmetcyslysleuthrserglylyshispro
102510301035
asncysargtyrlysglulysargglnasnlyssertyrvalval
104010451050
alacyslysproproglnlyslysaspserglnglnphehisleu
105510601065
valprovalhisleuaspargvalleu
10701075
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metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
aspileglnleuthrglnserproaspserleualavalserleugly
165170175
gluargalathrileasncyslysserserglnservalleutyrser
180185190
serileasnlysasntyrleualatrptyrglnglnlysproglygln
195200205
proprolysleuleuiletyrtrpalaserthrarggluserglyval
210215220
proaspargpheserglyserglyserglythraspphethrleuthr
225230235240
ileserserleuglnalagluaspvalalavaltyrtyrcysglngln
245250255
tyrtyrserthrprotyrthrpheglyglnglythrlysvalgluile
260265270
lysargglyglyserglyglyglyglyserglyglyglyserglygly
275280285
glyserglyglyserglyglnmetglnleuvalglnserglythrglu
290295300
vallyslysproglygluserleulysilesercyslysglysergly
305310315320
tyrglypheilethrtyrtrpileglytrpvalargglnmetprogly
325330335
lysglyleuglutrpmetglyileiletyrproglyaspsergluthr
340345350
argtyrserproserpheglnglyglnvalthrileseralaasplys
355360365
serileasnthralatyrleuglntrpserserleulysalaserasp
370375380
thralailetyrtyrcysalaglyglyserglyileserthrpromet
385390395400
aspvaltrpglyglnglythrthrvalthrvalserserglyglygly
405410415
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
420425430
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
435440445
glyglyglyglyserglyglyglyglyseralaalaglythrvalphe
450455460
thrthrvalgluaspleuglyserlysileleuleuthrcysserleu
465470475480
asnaspseralathrgluvalthrglyhisargtrpleulysglygly
485490495
valvalleulysgluaspalaleuproglyglnlysthrgluphelys
500505510
valaspseraspaspglntrpglyglutyrsercysvalpheleupro
515520525
gluprometglythralaasnileglnleuhisglyproproargval
530535540
lysalavallyssersergluhisileasngluglygluthralamet
545550555560
leuvalcyslyssergluservalproprovalthrasptrpalatrp
565570575
tyrlysilethraspsergluasplysalaleumetasnglyserglu
580585590
serargphephevalserserserglnglyargsergluleuhisile
595600605
gluasnleuasnmetglualaaspproglyglntyrargcysasngly
610615620
thrserserlysglyseraspglnalaileilethrleuargvalarg
625630635640
serhisleualaalaleutrpproleuleuglyilevalalagluval
645650655
leuvalleuvalthrileilepheiletyrglulysargarglyspro
660665670
gluaspvalleuaspaspaspaspalaglyseralaproleulysser
675680685
serglyglnhisglnasnasplysglylysasnvalargglnargasn
690695700
serserglyglyglyserglyglyglyserglyglyglyasplysthr
705710715720
histhrcysproprocysproalaprogluleuleuglyglyproser
725730735
valpheleupheproprolysprolysaspthrleumetileserarg
740745750
thrprogluvalthrcysvalvalvalaspvalserhisgluasppro
755760765
gluvallyspheasntrptyrvalaspglyvalgluvalhisasnala
770775780
lysthrlysproargglugluglntyrasnserthrtyrargvalval
785790795800
servalleuthrvalleuhisglnasptrpleuasnglylysglutyr
805810815
lyscyslysvalserasnlysalaleuproalaproileglulysthr
820825830
ileserlysalalysglyglnproarggluproglnvaltyrthrleu
835840845
proproserargaspgluleuthrlysasnglnvalserleuthrcys
850855860
leuvallysglyphetyrproseraspilealavalglutrpgluser
865870875880
asnglyglnprogluasnasntyrlysthrthrproprovalleuasp
885890895
seraspglyserphepheleutyrserlysleuthrvalasplysser
900905910
argtrpglnglnglyasnvalphesercysservalmethisgluala
915920925
leuhisasnhistyrthrglnlysserleuserleuserproglylys
930935940
glyglyserglyglylysprolysglymetthrserserglntrpphe
945950955960
lysileglnhismetglnproserproglnalacysasnseralamet
965970975
lysasnileasnlyshisthrlysargcyslysaspleuasnthrphe
980985990
leuhisglupropheserservalalaalathrcysglnthrprolys
99510001005
ilealacyslysasnglyasplysasncyshisglnserhisgly
101010151020
alavalserleuthrmetcyslysleuthrserglylyshispro
102510301035
asncysargtyrlysglulysargglnasnlyssertyrvalval
104010451050
alacyslysproproglnlyslysaspserglnglnphehisleu
105510601065
valprovalhisleuaspargvalleu
10701075
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metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnpheglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
glnmetglnleuvalglnserglythrgluvallyslysproglyglu
165170175
serleulysilesercyslysglyserglytyrglypheilethrtyr
180185190
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
195200205
glyileiletyrproglyaspsergluthrargtyrserproserphe
210215220
glnglyglnvalthrileseralaasplysserileasnthralatyr
225230235240
leuglntrpserserleulysalaseraspthralailetyrtyrcys
245250255
alaglyglyserglyileserthrprometaspvaltrpglyglngly
260265270
thrthrvalthrvalserserglyglyserglyglyglyglysergly
275280285
glyglyserglyglyglyserglyglyserglyaspileglnleuthr
290295300
glnserproaspserleualavalserleuglygluargalathrile
305310315320
asncyslysserserglnservalleutyrserserileasnlysasn
325330335
tyrleualatrptyrglnglnlysproglyglnproprolysleuleu
340345350
iletyrtrpalaserthrarggluserglyvalproaspargpheser
355360365
glyserglyserglythraspphethrleuthrileserserleugln
370375380
alagluaspvalalavaltyrtyrcysglnglntyrtyrserthrpro
385390395400
tyrthrpheglyglnglythrlysvalgluilelysargglyglygly
405410415
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
420425430
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
435440445
glyglyglyglyserglyglyglyglyseralaalaglythrvalphe
450455460
thrthrvalgluaspleuglyserlysileleuleuthrcysserleu
465470475480
asnaspseralathrgluvalthrglyhisargtrpleulysglygly
485490495
valvalleulysgluaspalaleuproglyglnlysthrgluphelys
500505510
valaspseraspaspglntrpglyglutyrsercysvalpheleupro
515520525
gluprometglythralaasnileglnleuhisglyproproargval
530535540
lysalavallyssersergluhisileasngluglygluthralamet
545550555560
leuvalcyslyssergluservalproprovalthrasptrpalatrp
565570575
tyrlysilethraspsergluasplysalaleumetasnglyserglu
580585590
serargphephevalserserserglnglyargsergluleuhisile
595600605
gluasnleuasnmetglualaaspproglyglntyrargcysasngly
610615620
thrserserlysglyseraspglnalaileilethrleuargvalarg
625630635640
serhisleualaalaleutrpproleuleuglyilevalalagluval
645650655
leuvalleuvalthrileilepheiletyrglulysargarglyspro
660665670
gluaspvalleuaspaspaspaspalaglyseralaproleulysser
675680685
serglyglnhisglnasnasplysglylysasnvalargglnargasn
690695700
serserglyglyglyserglyglyglyserglyglyglyasplysthr
705710715720
histhrcysproprocysproalaprogluleuleuglyglyproser
725730735
valpheleupheproprolysprolysaspthrleumetileserarg
740745750
thrprogluvalthrcysvalvalvalaspvalserhisgluasppro
755760765
gluvallyspheasntrptyrvalaspglyvalgluvalhisasnala
770775780
lysthrlysproargglugluglntyrasnserthrtyrargvalval
785790795800
servalleuthrvalleuhisglnasptrpleuasnglylysglutyr
805810815
lyscyslysvalserasnlysalaleuproalaproileglulysthr
820825830
ileserlysalalysglyglnproarggluproglnvaltyrthrleu
835840845
proproserargaspgluleuthrlysasnglnvalserleuthrcys
850855860
leuvallysglyphetyrproseraspilealavalglutrpgluser
865870875880
asnglyglnprogluasnasntyrlysthrthrproprovalleuasp
885890895
seraspglyserphepheleutyrserlysleuthrvalasplysser
900905910
argtrpglnglnglyasnvalphesercysservalmethisgluala
915920925
leuhisasnhistyrthrglnlysserleuserleuserproglylys
930935940
glyglyserglyglymetargalatyrtrpproaspvalilehisser
945950955960
pheproasnargserargphetrplyshisglutrpglulyshisgly
965970975
thrcysalaalaglnvalaspalaleuasnserglnlyslystyrphe
980985990
glyargserleugluleutyrarggluleuaspleuasnservalleu
99510001005
leulysleuglyilelysproserileasntyrtyrglnvalala
101010151020
aspphelysaspalaleualaargvaltyrglyvalileprolys
102510301035
ileglncysleuproproserglnaspglugluvalglnthrile
104010451050
glyglnilegluleucysleuthrlysglnaspglnglnleugln
105510601065
asncysthrgluproglygluglnproserprolysglngluval
107010751080
trpleualaasnglyalaalagluserargglyleuargvalcys
108510901095
gluaspglyprovalphetyrproproprolyslysthrlyshis
110011051110
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metglyserserthrileglugluglnalalysthrpheleuasplys
151015
pheasnhisglualagluaspleuphetyrglnserserleualaser
202530
trpasntyrasnthrasnilethrglugluasnvalglnasnmetasn
354045
asnalaglyasplystrpseralapheleulysgluglnserthrleu
505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglyglyglyglyserglyglyglyglyserglyglyglygly
130135140
serglyglyglyglyserglyglyglyglyserglyglyglyglyser
145150155160
glnmetglnleuvalglnserglythrgluvallyslysproglyglu
165170175
serleulysilesercyslysglyserglytyrglypheilethrtyr
180185190
trpileglytrpvalargglnmetproglylysglyleuglutrpmet
195200205
glyileiletyrproglyaspsergluthrargtyrserproserphe
210215220
glnglyglnvalthrileseralaasplysserileasnthralatyr
225230235240
leuglntrpserserleulysalaseraspthralailetyrtyrcys
245250255
alaglyglyserglyileserthrprometaspvaltrpglyglngly
260265270
thrthrvalthrvalserserglyglyserglyglyglyglysergly
275280285
glyglyserglyglyglyserglyglyserglyaspileglnleuthr
290295300
glnserproaspserleualavalserleuglygluargalathrile
305310315320
asncyslysserserglnservalleutyrserserileasnlysasn
325330335
tyrleualatrptyrglnglnlysproglyglnproprolysleuleu
340345350
iletyrtrpalaserthrarggluserglyvalproaspargpheser
355360365
glyserglyserglythraspphethrleuthrileserserleugln
370375380
alagluaspvalalavaltyrtyrcysglnglntyrtyrserthrpro
385390395400
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405410415
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420425430
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435440445
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450455460
thrthrvalgluaspleuglyserlysileleuleuthrcysserleu
465470475480
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485490495
valvalleulysgluaspalaleuproglyglnlysthrgluphelys
500505510
valaspseraspaspglntrpglyglutyrsercysvalpheleupro
515520525
gluprometglythralaasnileglnleuhisglyproproargval
530535540
lysalavallyssersergluhisileasngluglygluthralamet
545550555560
leuvalcyslyssergluservalproprovalthrasptrpalatrp
565570575
tyrlysilethraspsergluasplysalaleumetasnglyserglu
580585590
serargphephevalserserserglnglyargsergluleuhisile
595600605
gluasnleuasnmetglualaaspproglyglntyrargcysasngly
610615620
thrserserlysglyseraspglnalaileilethrleuargvalarg
625630635640
serhisleualaalaleutrpproleuleuglyilevalalagluval
645650655
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660665670
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675680685
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690695700
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705710715720
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725730735
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740745750
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755760765
gluvallyspheasntrptyrvalaspglyvalgluvalhisasnala
770775780
lysthrlysproargglugluglntyrasnserthrtyrargvalval
785790795800
servalleuthrvalleuhisglnasptrpleuasnglylysglutyr
805810815
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820825830
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835840845
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850855860
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865870875880
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885890895
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900905910
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915920925
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930935940
glyglyserglyglymetargalatyrtrpproaspvalilehisser
945950955960
pheproasnargserargphetrplyshisglutrpglulyshisgly
965970975
thrcysalaalaglnvalaspalaleuasnserglnlyslystyrphe
980985990
glyargserleugluleutyrarggluleuaspleuasnservalleu
99510001005
leulysleuglyilelysproserileasntyrtyrglnvalala
101010151020
aspphelysaspalaleualaargvaltyrglyvalileprolys
102510301035
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104010451050
glyglnilegluleucysleuthrlysglnaspglnglnleugln
105510601065
asncysthrgluproglygluglnproserprolysglngluval
107010751080
trpleualaasnglyalaalagluserargglyleuargvalcys
108510901095
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110011051110
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151015
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202530
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354045
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505560
alaglnmettyrproleuglngluileglnasnleuthrvallysleu
65707580
glnleuglnalaleuglnglnasnglyserservalleusergluasp
859095
lysserlysargleuasnthrileleuasnthrmetserthriletyr
100105110
serthrglyglyglyglyglyserglyglyglyglyserglyglygly
115120125
glyserglnmetglnleuvalglnserglythrgluvallyslyspro
130135140
glygluserleulysilesercyslysglyserglytyrglypheile
145150155160
thrtyrtrpileglytrpvalargglnmetproglylysglyleuglu
165170175
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180185190
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195200205
alatyrleuglntrpserserleulysalaseraspthralailetyr
210215220
tyrcysalaglyglyserglyileserthrprometaspvaltrpgly
225230235240
glnglythrthrvalthrvalserserglyglyserglyglyglygly
245250255
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260265270
leuthrglnserproaspserleualavalserleuglygluargala
275280285
thrileasncyslysserserglnservalleutyrserserileasn
290295300
lysasntyrleualatrptyrglnglnlysproglyglnproprolys
305310315320
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325330335
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340345350
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355360365
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370375380
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385390395400
glythrvalphethrthrvalgluaspleuglyserlysileleuleu
405410415
thrcysserleuasnaspseralathrgluvalthrglyhisargtrp
420425430
leulysglyglyvalvalleulysgluaspalaleuproglyglnlys
435440445
thrgluphelysvalaspseraspaspglntrpglyglutyrsercys
450455460
valpheleuprogluprometglythralaasnileglnleuhisgly
465470475480
proproargvallysalavallyssersergluhisileasnglugly
485490495
gluthralametleuvalcyslyssergluservalproprovalthr
500505510
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515520525
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530535540
gluleuhisilegluasnleuasnmetglualaaspproglyglntyr
545550555560
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565570575
leuargvalargserhisleualaalaleutrpproleuleuglyile
580585590
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595600605
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610615620
proleulysserserglyglnhisglnasnasplysglylysasnval
625630635640
argglnargasnserserglyglyglyserglyglyglyserglygly
645650655
glyasplysthrhisthrcysproprocysproalaprogluleuleu
660665670
glyglyproservalpheleupheproprolysprolysaspthrleu
675680685
metileserargthrprogluvalthrcysvalvalvalaspvalser
690695700
hisgluaspprogluvallyspheasntrptyrvalaspglyvalglu
705710715720
valhisasnalalysthrlysproargglugluglntyrasnserthr
725730735
tyrargvalvalservalleuthrvalleuhisglnasptrpleuasn
740745750
glylysglutyrlyscyslysvalserasnlysalaleuproalapro
755760765
ileglulysthrileserlysalalysglyglnproarggluprogln
770775780
valtyrthrleuproproserargaspgluleuthrlysasnglnval
785790795800
serleuthrcysleuvallysglyphetyrproseraspilealaval
805810815
glutrpgluserasnglyglnprogluasnasntyrlysthrthrpro
820825830
provalleuaspseraspglyserphepheleutyrserlysleuthr
835840845
valasplysserargtrpglnglnglyasnvalphesercysserval
850855860
methisglualaleuhisasnhistyrthrglnlysserleuserleu
865870875880
serproglylysglyglyserglyglyglymetalaserleuleucys
885890895
cysglyprolysleualaalacysglyilevalleuseralatrpgly
900905910
valilemetleuilemetleuglyilephepheasnvalhisserala
915920925
valleuilegluaspvalprophethrglulysaspphegluasngly
930935940
proglnasniletyrasnleutyrgluglnvalsertyrasncysphe
945950955960
ilealaalaglyleutyrleuleuleuglyglypheserphecysgln
965970975
valargleuasnlysarglysglutyrmetvalarg
980985
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151015
cyscysglnproarggluglnserglnprohisthrargtrpaspala
202530
glycysglyileglnhisproglyglygluglupheargthrleugly
354045
glyalaargalatyrargvalproasnserglngluglyargserser
505560
prothrargphepheproalaprogluglyproalahiscyspheval
65707580
serserproaspargalaphetrpvalserglugluvalglnargleu
859095
leuleuserasnalacysglnprolysglucysasnglyvallysile
100105110
provalaspalaserlysproasnproasnaspvalglupheaspasn
115120125
leutyrleuaspmetasnglyileilehisprocysthrhisproglu
130135140
asplysproalaprolysasngluaspglumetmetvalalailephe
145150155160
glutyrileaspargleupheserilevalargproargargleuleu
165170175
tyrmetalaileaspglyvalalaproargalalysmetasnglngln
180185190
argserargargpheargalaserlysgluglymetglualaalaval
195200205
glulysglnargvalargglugluileleualalysglyglypheleu
210215220
proproglugluilelysgluargpheaspserasncysilethrpro
225230235240
glythrgluphemetaspasnleualalyscysleuargtyrtyrile
245250255
alaaspargleuasnasnaspproglytrplysasnleuthrvalile
260265270
leuseraspalaseralaproglygluglygluhislysilemetasp
275280285
tyrileargargglnargalaglnproasnhisaspproasnthrhis
290295300
hiscysleucysglyalaaspalaaspleuilemetleuglyleuala
305310315320
thrhisgluproasnphethrileileargglugluphelysproasn
325330335
lysprolysprocysglyleucysasnglnpheglyhisgluvallys
340345350
aspcysgluglyleuproargglulyslysglylyshisaspgluleu
355360365
alaaspserleuprocysalagluglyglupheilepheleuargleu
370375380
asnvalleuargglutyrleugluarggluleuthrmetalaserleu
385390395400
prophethrpheaspvalgluargserileaspasptrpvalphemet
405410415
cysphephevalglyasnasppheleuprohisleuproserleuglu
420425430
ilearggluasnalaileaspargleuvalasniletyrlysasnval
435440445
valhislysthrglyglytyrleuthrgluserglytyrvalasnleu
450455460
glnargvalglnmetilemetleualavalglygluvalgluaspser
465470475480
ilephelyslysarglysaspaspgluaspserpheargargarggln
485490495
lysglulysarglysargmetlysargaspglnproalaphethrpro
500505510
serglyileleuthrprohisalaleuglyserargasnserprogly
515520525
serglnvalalaserasnproargglnalaalatyrglumetargmet
530535540
glnasnasnserserproserileserproasnthrserphethrser
545550555560
aspglyserproserproleuglyglyilelysarglysalagluasp
565570575
seraspsergluprogluprogluaspasnvalargleutrpgluala
580585590
glytrplysglnargtyrtyrlysasnlyspheaspvalaspalaala
595600605
aspglulyspheargarglysvalvalglnsertyrvalgluglyleu
610615620
cystrpvalleuargtyrtyrtyrglnglycysalasertrplystrp
625630635640
tyrtyrprophehistyralaprophealaseraspphegluglyile
645650655
alaaspmetproserasppheglulysglythrlysprophelyspro
660665670
leugluglnleumetglyvalpheproalaalaserglyasnpheleu
675680685
proprosertrparglysleumetseraspproaspserserileile
690695700
aspphetyrprogluaspphealaileaspleuasnglylyslystyr
705710715720
alatrpglnglyvalalaleuleuprophevalaspgluargargleu
725730735
argalaalaleuglugluvaltyrproaspleuthrproglugluthr
740745750
argargasnserleuglyglyaspvalleuphevalglylyshishis
755760765
proleuhisasppheileleugluleutyrglnthrglyserthrglu
770775780
provalgluvalproprogluleucyshisglyileglnglylysphe
785790795800
serleuaspgluglualaileleuproaspglnilevalcysserpro
805810815
valprometleuargaspleuthrglnasnthrvalvalserileasn
820825830
phelysaspproglnphealagluasptyrilephelysalavalmet
835840845
leuproglyalaarglysproalaalavalleulysproserasptrp
850855860
glulysserserasnglyargglntrplysproglnleuglypheasn
865870875880
argaspargargprovalhisleuaspglnalaalapheargthrleu
885890895
glyhisvalmetproargglyserglythrglyiletyrserasnala
900905910
alaproproprovalthrtyrglnglyasnleutyrargproleuleu
915920925
argglyglnalaglnileprolysleumetserasnmetargprogln
930935940
aspsertrpargglyproproproleupheglnglnglnargpheasp
945950955960
argglyvalglyalagluproleuleuprotrpasnargmetleugln
965970975
thrglnasnalaalapheglnproasnglntyrglnmetleualagly
980985990
proglyglytyrproproargargaspaspargglyglyargglngly
99510001005
tyrproarggluglyarglystyrproleuproproprosergly
101010151020
argtyrasntrpasn
1025
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151015
leusergluvalvallysgluhisglnileproglupheaspasnleu
202530
tyrleuaspmetasnglyileilehisglncysserhisproasnasp
354045
aspaspvalhispheargileseraspasplysilephethraspile
505560
phehistyrleugluvalleupheargileilelysproarglysval
65707580
phephemetalavalaspglyvalalaproargalalysmetasngln
859095
glnargglyargargpheargseralalysglualagluasplysile
100105110
lyslysalaileglulysglygluthrleuprothrglualaargphe
115120125
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130135140
gluhisleulystyrphevalasnmetlysileserthrasplysser
145150155160
trpglnglyvalthriletyrpheserglyhisgluthrproglyglu
165170175
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180185190
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195200205
leuilemetleuglyleuthrserhisglualahispheserleuleu
210215220
argglugluvalargpheglyglylyslysthrglnargvalcysala
225230235240
proglugluthrthrphehisleuleuhisleuserleumetargglu
245250255
tyrileasptyrglupheservalleulysglulysilethrphelys
260265270
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275280285
valglyasnasppheileprohisleuprohisleuhisileasnhis
290295300
aspalaleuproleuleutyrglythrtyrvalthrileleuproglu
305310315320
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325330335
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340345350
gluvalphevalaspleulystrpphegluserlysvalglyasnlys
355360365
tyrleuasnglualaalaglyvalalaalagluglualaargasntyr
370375380
lysglulyslyslysleulysglyglngluasnserleucystrpthr
385390395400
alaleuasplysasngluglyglumetilethrserlysaspasnleu
405410415
gluaspgluthrgluaspaspaspleuphegluthrgluphearggln
420425430
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435440445
aspasppheleualaaspglnalaalacystyrvalglnalailegln
450455460
trpileleuhistyrtyrtyrhisglyvalglnsertrpsertrptyr
465470475480
tyrprotyrhistyralapropheleuseraspilehisasnileser
485490495
thrleulysilehisphegluleuglylysprophelyspropheglu
500505510
glnleuleualavalleuproalaalaserlysasnleuleuproala
515520525
cystyrglnhisleumetthrasngluaspserproileileglutyr
530535540
tyrproproaspphelysthraspleuasnglylysglnglnglutrp
545550555560
glualavalvalleuilepropheileaspglulysargleuleuglu
565570575
alametgluthrcysasnhisserleulyslysglugluarglysarg
580585590
asnglnhisserglucysleumetcystrptyraspargaspthrglu
595600605
pheiletyrproserprotrpproglulyspheproalailegluarg
610615620
cyscysthrargtyrlysileileserleuaspalatrpargvalasp
625630635640
ileasnlysasnlysilethrargileaspglnlysalaleutyrphe
645650655
cysglypheprothrleulyshisilearghislysphepheleulys
660665670
lysserglyvalglnvalpheglnglnserserargglygluasnmet
675680685
metleugluileleuvalaspalagluseraspgluleuthrvalglu
690695700
asnvalalaserservalleuglylysservalphevalasntrppro
705710715720
hisleugluglualaargvalvalalavalseraspglygluthrlys
725730735
phetyrleuglugluproproglythrglnlysleutyrserglyarg
740745750
thralaproproserlysvalvalhisleuglyasplysgluglnser
755760765
asntrpalalysgluvalglnglyilesergluhistyrleuargarg
770775780
lysglyileileileasngluthrseralavalvaltyralaglnleu
785790795800
leuthrglyarglystyrglnileasnglnasnglygluvalargleu
805810815
glulysglntrpserlysglnvalvalprophevaltyrglnthrile
820825830
vallysaspileargalapheaspserargpheserasnilelysthr
835840845
leuaspaspleupheproleuargsermetvalphemetleuglythr
850855860
protyrtyrglycysthrglygluvalglnaspserglyaspvalile
865870875880
thrgluglyargileargvalilepheserileprocysgluproasn
885890895
leuaspalaleuileglnasnglnhislystyrserilelystyrasn
900905910
proglytyrvalleualaserargleuglyvalserglytyrleuval
915920925
serargphethrglyserilepheileglyargglyserargargasn
930935940
prohisglyasphislysalaasnvalglyleuasnleulyspheasn
945950955960
lyslysasnglugluvalproglytyrthrlyslysvalglyserglu
965970975
trpmettyrserseralaalagluglnleuleualaglutyrleuglu
980985990
argalaprogluleuphesertyrilealalysasnserglngluasp
99510001005
valphetyrgluaspaspiletrpproglygluasngluasngly
101010151020
alaglulysvalglngluileilethrtrpleulysglyhispro
102510301035
valserthrleuserargsersercysaspleuglnileleuasp
104010451050
alaalailevalglulysilegluglugluvalglulyscyslys
105510601065
glnarglysasnasnlyslysvalargvalthrvallysprohis
107010751080
leuleutyrargproleugluglnglnhisglyvalileproasp
108510901095
argaspalagluphecysleupheaspargvalvalasnvalarg
110011051110
gluasnpheservalprovalglyleuargglythrileilegly
111511201125
ilelysglyalaasnargglualaaspvalleuphegluvalleu
113011351140
pheaspgluglupheproglyglyleuthrileargcysserpro
114511501155
glyargglytyrargleuprothrseralaleuvalasnleuser
116011651170
hisglyserargsergluthrglyasnglnlysleuthralaile
117511801185
vallysproglnproalavalhisglnhisserserserserser
119011951200
valserserglyhisleuglyalaleuasnhisserproglnser
120512101215
leuphevalprothrglnvalprothrlysaspaspaspgluphe
122012251230
cysasniletrpglnserleuglnglyserglylysmetglntyr
123512401245
pheglnprothrileglnglulysglyalavalleuproglnglu
125012551260
ileserglnvalasnglnhishislysserglypheasnaspasn
126512701275
servallystyrglnglnarglyshisaspprohisarglysphe
128012851290
lysgluglucyslysserprolysalaglucystrpserglnlys
129513001305
metserasnlysglnproasnserglyilegluasnpheleuala
131013151320
serleuasnileserlysgluasngluvalglnserserhishis
132513301335
glygluproproserglugluhisleuserproglnserpheala
134013451350
metlysglythrargmetleulysgluileleulysileaspgly
135513601365
serasnthrvalasphislysasngluilelysglnilealaasn
137013751380
gluileprovalserserasnargargaspglutyrglyleupro
138513901395
serglnprolysglnasnlyslysleualasertyrmetasnlys
140014051410
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141514201425
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143014351440
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144514501455
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146014651470
glnvallysleuserasnglyleuleuvalhisglyproglncys
147514801485
hissergluasnglualalysglulysalaalaleuphealaleu
149014951500
glnglnleuglyserleuglymetasnpheproleuprosergln
150515101515
valphealaasntyrproseralavalproproglythrilepro
152015251530
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153515401545
hisleupheglysermetprotrpglyproservalprovalpro
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354045
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370375380
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101010151020
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105510601065
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1175
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354045
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202530
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354045
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180185190
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195200205
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210215220
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225230235240
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245250255
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260265270
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275280285
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290295300
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305310315320
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340345350
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355360365
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370375380
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202530
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354045
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65707580
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859095
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100105110
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130135140
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145150155160
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165170175
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180185190
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195200205
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210215220
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225230235240
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245250255
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260265270
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275280285
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340345350
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355360365
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202530
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354045
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505560
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65707580
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100105110
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210215220
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225230235240
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245250255
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260265270
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275280285
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290295300
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305310315320
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340345350
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355360365
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370375380
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385390
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202530
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354045
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505560
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65707580
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859095
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100105110
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115120125
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130135140
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145150155160
glycysglyglyglyalathrcysalaglyglythralaalaglygly
165170175
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180185190
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195200205
cysthrglyglythralaalacysalaglythrcyscysglythrgly
210215220
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225230235240
cyscysglyglyalaglycysalaalaglyglycyscysalaalaala
245250255
thralaglyglyglyglythrthrcysalathralaalaglyglythr
260265270
alacysglyglycyscyscysglythralacysthrglyalaalacys
275280285
cyscysglyglyglythralaglyglycysthrglycysthrthrgly
290295300
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305310315320
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325330335
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340345350
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355360365
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370375380
alathrthralaglycysthrcyscysala
385390