结肠直肠癌预后的制作方法

专利名称：结肠直肠癌预后的制作方法
背景技术：
本申请为2003年8月28日美国申请NO.10/651,237的部分后续申请。
本发明涉及基于生物样品的基因表达模式的结肠直肠癌的预后。
结肠直肠癌是具有复杂起源的异源性疾病，结肠直肠癌患者接受治疗后复发的概率与肿瘤在肠壁浸润的程度以及结节累及的出现与否有关。这些因素也是目前进行Duke’s分期的基础。Duke’s A期病变限于结肠或直肠的粘膜下层。Duke’s B期肿瘤侵染肌肉层并且能浸润直肠或结肠肠壁。Duke’s C期疾病包括出现区域淋巴结转移以及任何程度的肠壁侵染。
外科切除术在治疗早期的结肠直肠癌方面效果显著，对于Duke’s A期和B期患者分别有95％和75％的治愈率。Duke’s C期阳性淋巴结的存在，预示着患者在五年内复发的可能性为60％。目前对于Duke’s C期患者进行治疗的标准作法是在手术后进行化疗，这样能够将复发率降到40％-50％。但是由于相对较低的复发率，对Duke’s B期患者进行术后化疗的好处难以察觉并且依然存在争议。然而，由于Duke’s B期的分级存在一定的缺陷，大约有20-30％的这类患者表现的更像是在Duke’s C期，并且在5年内复发。
因此显然需要一种比结节累及更好的预后因子，来区分Duke’s B期患者中可能复发的群体和将存活的群体。在Wang的美国专利申请US10/403,499中提到了利用基因表达模式进行结肠癌的预测。本说明书中提供了与之不同的基因表达模式。
发明概述本发明为一种评估诊断为结肠直肠癌或接受结肠直肠癌治疗的人群中结肠直肠癌复发的可能性的方法。该方法包括对基因表达模式的分析。
在本发明的一方面，基因表达模式包括至少7个特定的基因。
在本发明的另一方面，基因表达模式包括至少15个特定的基因。
在本发明的又一方面，基因表达模式包括上述的7个特定基因和15个特定的基因。在一个实施方案中，基因表达模式包括23个基因。
用于实施本发明方法的制品也是本发明的一个方面。这些制品包括固定于机器可读介质比如计算机可读介质上的基因表达模式或其表示物。
识别基因表达模式的制品也包括用于捕获和/或显示基因是否表达或表达的水平的基质或表面，比如微阵列。
在本发明的再一方面的试剂盒，试剂盒中包含根据基因表达分析结肠直肠癌预后复发的试剂。
附图简述

图1是在根据7基因组合的实施例中所述的，由27名患者(其中14名存活，13名复发)的独立患者数据组构建的标准Kaplan-Meier图。按照芯片数据预测的结果将患者分为两类。纵轴显示每一类中无病存活患者的概率。
图2是在根据15基因组合的实施例中所述的，由9名患者(其中6名存活，3名复发)的独立患者数据组构建的标准Kaplan-Meier图。按照芯片数据预测的结果将患者分为两类。纵轴显示在每一类中无病存活患者的概率。
图3是根据实施例中所述的患者数据构建的标准Kaplan-Meier图，其中使用22-基因模式以及钙粘着蛋白17(Seq.ID 6)组成的基因组合。测试了36个样品(20个存活，16个复发)。根据23-基因面板的芯片数据预测的结果，将患者分为两类。纵轴显示在每一类患者中无病存活的概率。
发明详述仅仅发现组织样品中特定的核酸序列存在与否并没有多少诊断或预测价值。另一方面，不同的蛋白、多肽或mRNA表达的信息正逐渐受到重视。基因组中存在具有表达蛋白、多肽或mRNA的潜在可能的核酸序列(这样的序列被称为“基因”)本身并不能决定是否在指定的细胞中表达该蛋白、多肽或mRNA。基因是否表达蛋白、多肽或mRNA以及表达到什么程度取决于许多复杂的因素。不考虑在理解和评估这些因素上的困难，检测基因的表达能够为比如肿瘤发生、转移、细胞凋亡以及其它临床相关现象等重要事件的发生提供有用信息。通过基因表达模式能够发现基因激活或失活程度的相对指标。本发明的基因表达模式用于对结肠直肠癌患者进行预后和治疗。
需要收集患者样本制备样品。本发明方法中使用的患者样本是怀疑含有病变细胞的样本，比如来自结肠样品的原发肿瘤或来自手术边缘的上皮细胞。激光捕获显微切割(LCM)技术是一种选择待研究细胞的方法，并使由于细胞种类的异质性所导致的变异性最小化。因此，正常细胞和癌细胞在基因表达方面中度或是微小的改变均易于检测到。样本也包括在外周血中提取的循环上皮细胞。许多方法可以获得样本细胞，最优选使用Immunivest Corp公司申请的美国专利US6,136,182中的磁分离技术，在此引入其内容作为参考。一旦获得了含有目的细胞的样本，提取RNA并且扩增，并优选通过微阵列同时获得适当基因组合中基因的表达模式。
优选的构建基因表达模式的方法包括，测定编码蛋白或多肽的基因产生的RNA的量。这可以通过逆转录酶PCR(RT-PCR)、竞争性RT-PCR、实时RT-PCR、差异显示RT-PCR、Northern Blot分析和其他相关实验实现。尽管可以使用单个PCR反应来实施这些技术，最好是扩增来自mRNA的互补DNA(cDNA)或是互补RNA(cRNA)并且通过微阵列来进行分析。大量不同的阵列构型及其生产方法已经是本领域技术人员公知的，并且公开于如下的美国专利中US5,445,934；US5,532,128；US5,556,752；US5,242,974；US5,384,261；US5,405,783；US5,412,087；US5,424,186；US5,429,807；US5,436,327；US5,472,672；US5,527,681；US5,529,756；US5,545,531；US5,554,501；US5,561,071；US5,571,639；US5,593,839；US5,599,695；US5,624,711；US5,658,734和US5,700,637；在此引入其公开内容作为参考。
微阵列技术能够同时测量上千个基因稳定状态的mRNA的水平，因而可以作为一种很好的工具用来识别失控细胞增殖的启动、抑制或调节。两种微阵列技术目前正被广泛地应用。第一种是cDNA阵列，第二种是寡核苷酸阵列。虽然这些芯片在结构上存在不同，但本质上两者其所有下游的数据分析和输出都是相同的。分析的结果通常是来自标记探针的信号强度测定结果，其中所述探针用来探测样本中与芯片已知位点的核酸序列杂交的来自样品的cDNA序列。典型地，信号的亮度与样本细胞中cDNA的含量，以及相应的mRNA的量成比例。大量这种技术是可获得的并且是有用的。优选的检测基因表达的方法公开于Linsley等的美国专利US6,271,002；Friend等的US6,218,122；Peck等的US6,218,114；和Wang等的US6,004,755中，在此引入其公开内容作为参考。
表达水平的分析是通过比较信号的强度实现的。最好建立一个测试样本中基因表达强度相对于对照样本中基因表达强度的比值基质，例如，来自病变组织的基因表达强度可以与同类正常组织中产生的基因表达强度比较(例如，病变的结肠组织样本与正常的结肠组织样本相比较)。表达强度的比率显示了测试样本与对照样本间基因表达的倍数变化。
基因表达模式可以用多种方式显示。最常用的方式是将原始荧光强度或比值基质排列以树状图表示，其中列表示试验样本，行表示基因。处理数据使具有相似表达模式的基因彼此相互接近。每个基因的表达比率将会用颜色标记出来。例如，小于1的比率(表明下调)将会显示为图谱上的蓝色部分，而大于1的比率(表明上调)将会显示为光谱上的红色部分。商业上可购买到的用于显示这种数据的计算机软件包括Silicon Genetics公司的“GENESPRING”以及Partek公司的“DISCOVERY”和“INFER”。
本发明方法中所使用的被调控基因显示于实施例中。相对于不复发的患者，复发的结肠癌患者中差异表达的基因或是上调或是下调。上调或下调是相对的术语，是指基因的表达量相对某种基线有可检测到的差异(超出了检测系统的噪音影响)。在本发明中，上述基线是指在不复发患者所测量得到的基因表达量。因而在病变细胞(来自复发患者)中目的基因相对于使用相同测量方法测定的基线水平而言或是上调或是下调。本发明上下文中所述“病变”是指随着失控细胞增殖的出现，身体状态发生变化从而阻断、扰乱或是可能扰乱正常的身体机能。当患者的基因型或表型的某些方面与患有某种疾病的表现一致时就被诊断为患有该疾病。然而，实施诊断或预后还包括确定病变/状态组织，例如确定复发的可能性和治疗监控。在治疗监控方面，通过比较全过程的基因表达情况，确定基因表达模式是否发生变化，或者是否改变到与正常组织的模式更为一致来对给定疗程的效果作出临床判断。
优选地，上调和下调的水平根据杂交的微阵列探针测量强度的成倍变化来进行区分。2.0倍的差异或是p值小于.05对于作出这种区分是优选。也就是说，当基因在病变/复发细胞中相对于正常/不复发细胞表现出表达水平差异时，其在病变细胞中的表达强度至少是正常细胞中的2倍以上，或是在正常细胞的2倍以下。优选倍数差异大的基因用于诊断或预后工具中。用于本发明的基因表达模式的基因，其产生区别于正常或非调控基因的信号的表达水平，该信号量超过临床试验仪器的背景噪音。
统计值能够确定地将经调控基因与未调控基因和噪音进行区分。统计学试验能够识别不同样本群体间差异最大的基因。t检验是一种可靠的用于寻找两个群体间明显的差异的统计学方法。p值越低，不同组之间基因显示差异的证据就越有说服力。然而，由于微阵列每次测量不止一个基因，将有上万个统计学检测同时进行。因此，不太可能看到完全是偶然出现的小的p值，同时能够根据Sidak校正和随机/排列试验来进行p值的修正。t检验中在.05以下的p值是该基因存在显著差异的证据。经过Sidak因子校正后小于.05的p值则是更加显著的证据。当每个群体中均有大量的样本存在时，随机/排列试验后在0.05以下的p值是存在明显差异最具说服力的证据。
用于选择能够产生比非调控基因或噪音产生的信号更强信号的基因的另一个参数是使用绝对信号差异值。优选地，受调控的基因表达产生的信号至少与正常或非调控基因的信号有20％的差异(在绝对值的基础上)。更优选地，上述基因与正常或非调控基因的表达模式间至少有30％的差异。
基因被分为几组，从一组基因中获得的一套基因的信息可以作为进行诊断、预后或治疗选择等临床判断的可靠的基础。这些套基因构成了发明的基因组合。本发明中，根据所用基因组合作出的判断包括对结直肠癌及其复发概率的判断，最优选对Duke B期患者进行判断。象常见的诊断标记一样，通常希望能够仅使用最少量的标记即可足以进行正确的医学判断。这避免了使用那些悬而未决需作进一步分析的治疗措施带来的延误，同时又避免了时间和资源的不合理使用。
优选地，构建这样的组合以致该组合中的基因组合相对于单个基因或随机的基因组合而言，具有更好的灵敏度和特异性。在本发明中，组合的灵敏度反映在基因在病变状态下相对于正常状态下所表现出的基因表达的倍数差异上。特异性反映于基因表达信号与目的情况相关程度的统计学测量中。例如，标准偏差能够用于这种测量。对于在一个基因组合中的一组基因，表达测量值的标准偏差越小其特异性越大。检测其他变量比如相关系数也能够实现同样的功能。
一种建立基因表达组合的方法是通过使用优化算法，例如常用于建立股票投资组合的平均方差算法。该方法在Tim Jatkoe等人于2003年3月21日申请的名为“组合选择”的专利申请中有详细的描述。基本上，该方法需要建立一组输入值(金融应用中的股票，本发明中指通过强度测定的表达)并且优化回报值(例如产生的信号)，对其进行接收并使用，同时最小化回报值的可变性。许多商务软件可以进行这种操作。优选使用“Wagner联合均值—方差优化应用程序”，本说明书中将其简称为“Wagner软件”。该软件优选使用“Wagner联合均值—方差优化应用程序”的函数来测定有效界值和Markowitz意义上优选的优化组合。使用软件时需要转换微阵列数据以便其能够作为输入处理，如同将软件用作预期的金融分析目的时进行股票回报和风险检测的方式相同。
在选择基因组合的过程中也可以使用直接推断规则。优选的，该规则在生物学和对产生临床结果的技术的理解的基础上进行公式化。更优选地，它们用于优化方法的输出。例如，组合选择的平均方差法，能够用于分析结肠直肠癌患者中大量基因差异表达的微阵列数据。该方法获得的输出是一组优化了的基因，其中包括一些在外周血和病变组织中都表达的基因。如果用于测试方法的样本来自于外周血，而一些在乳腺癌样本中差异表达的基因在外周血中同样也差异表达，此时可使用直接推断规则，其中从去除了在外周血中差异表达基因的有效界值中，选择基因组合。当然，该规则也可以在有效界值生成前使用，例如在数据预选的时候应用该规则。
其他与所述生物学问题无关的直接推断规则同样能被应用。例如，能够应用基因组合中仅有一定比例能够被一个或一组特殊的基因表示的规则。商业软件例如Wagner软件能够容易的提供这种直接推断规则。这是很有用的，例如，当除了准确性和精密度以外的其他因素(例如预期许可费)对包括一个或多个基因的需求有影响的时候。
本发明的方法包括通过比较不同基因(或基因组合)的基因表达模式进行预测。组成基因组合的每个基因的基因表达模式固定在介质上，例如计算机可读的介质。其存在许多种形式。例如，可以建立表格，其输入值表示疾病的信号范围(例如强度值)。真实患者的数据用来与表格中的值进行比较，以判断患者样本是正常的还是发生了病变。在更复杂的实施方案中，表达信号(如荧光强度)的模式以数字化或图形化的形式记录下来。与患者样本结合的基因组合中的基因表达模式用来与上述表达模式比较。应用模式比较软件来判断是否患者样本具有显示疾病复发的模式。当然，这些比较也能用来判断是否患者不可能复发疾病。然后将样本的表达模式与对照细胞的基因组合相比较。如果样本表达模式与结肠直肠癌复发的表达模式一致时，那么(在缺乏其它医学考虑的情况下)患者将被当作即将复发的患者来进行治疗。如果样本表达模式与正常/对照细胞的表达模式一致时，患者将诊断为结直肠癌阴性。
本发明优选的表达模式为表2中给出的7基因组合和表3中给出的15基因组合。更优选，使用将上述7基因与15基因组合起来构成的基因组合。最优选，由其它能够独立检验结直肠预后的基因，如钙粘着蛋白17(Seq.ID No.6)与表2和表3中给出的基因组合组成的基因表达组合(表4)。该最优选的组合能够最好的区分Duke’s B期患者中复发高危群体与不会复发的群体。一旦确定了高危患者，将能够通过辅助性疗法对其进行治疗。其它能够替代钙粘着蛋白17的独立预后鉴定基因包括，但不限于，序列为Seq ID No.29-94的基因。
本发明中，最优选的分析患者基因表达模式进行结肠癌预测的方法是通过使用Cox风险分析程序。最优选地，该分析使用S-Plus软件(可购于Insightful公司)进行。使用该方法，对基因表达模式与足以表明复发的表达模式(即模式中基因组合的表达水平预示了复发)进行比较。使用已经确定了临界值的Cox风险模型比较两种模式的相似性(已知复发的与患者比较)，判断患者的模式是否超过了临界值。如果超过了，那么患者将被确定为会复发的病人并且进行相应的治疗，例如辅助性治疗。如果患者的表达模式没有超过临界值，那么他们将被确定为不会复发的病人。其他的分析工具也能用来解决该问题，例如线性鉴别分析，逻辑回归分析以及神经网络方法。
许多其它常见的模式识别方法也是可行的。下面的参考文件提供了其中的一些例子加权表决Golub，TR.，Slonim，DK.，Tamaya，P.，Huard，C.，Gaasenbeek，M，Mesirov，JP.，Coller，H.，Loh，L.，Downing，JR，Caligiuri，MA.，Bloomfield，CD.，Lander，ES.癌症的分子分级通过检测基因的表达进行等级的确定和预测.Science 286531-537，1999支持矢量机器Su，AI.，Welsh，JB.，Sapinoso，LM.，Kern，SG.，Dimitrov，P.，Lapp，H.，Schultz PG.，Powell，SM.，Moskaluk，CA.，Frierson，HF.Jr.，Hampton，GM.使用基因表达信号进行人类癌症的分子分级.Cancer Research 6177388-93，2001Ramaswamy，S.，Tamayo，P.，Rifkin.，Mukherjee，S.，Yeang，CH.，Angelo，M.，Ladd，C.，Reich，M.，Latulippe，E.，Mesirov，JP.，Poggio，T.，Gerald，W.，Loda，M.，Lander，ES.，Gould，TR.根据肿瘤基因表达信号诊断多类癌症Proceedings of National Academy ofSciences of the USA 9815149-15154，2001K-最临近值Ramaswamy，S.，Tamayo，P.，Rifkin，R.，Mukherjee，S.，Yeang，CH.，Angelo，M.，Ladd，C.，Reich，M.，Latulippe，E.，Mesirov，JP.，Poggio，T.，Gerald，W.，Loda，M，Lander，ES.，Gould，TR.根据肿瘤基因表达信号诊断多类癌症Proceedings of the NationalAcademy of Sciences of the USA 9815149-15154，2001相关系数van’t Veer LJ，Dai H，van de Vijver MJ，He YD，Hart AA，Mao M，Peterse HL，vander Kooy K，Marton MJ，Witteveen AT，Schreiber GJ，Kerkhoven RM，RobertsC，Linsley PS，Bernards R，Friend SH.根据基因表达模式预测乳腺癌的临床结果.Nature.2002 Jan 31；415(6871)530-6.
本发明中的基因表达模式同样可以与其它的用于癌症诊断、预后或治疗监控的非遗传诊断方法联合使用。例如，在一些情况下将上述基于基因表达的诊断方法与传统标记如血清蛋白标记(例如癌胚抗原)的数据结合是很有益的。有很多种这样的标记物其中包括CEA分析物。在一种上述方法中，治疗的患者被定期抽血，而后进行上述一种血清标记的酶免疫测定。当标记的浓度显示肿瘤复发或是治疗失败，对样本源作基因表达分析。在怀疑肿块存在的地方，进行针吸采样，对从肿块中获得的细胞的基因表达模式进行上述分析。可选择地，组织样本也能够从以前进行肿瘤切除的组织附近的区域中提取。这种方法在使用其他测试结果不明确的时候尤其有效。
本发明的制品包括用于治疗、诊断、预后以及其他疾病评估的基因表达模式的表示物。表达模式的表示物将归结为能够被机器自动读取的介质，例如计算机可读介质(磁盘，光盘等等)。本发明的制品还包括分析这些介质上基因表达模式的操作指南。例如，制品包括具有比较上述基因组合中基因表达模式的计算机操作指南的CD-ROM。制品也包括数字记录的基因表达模式，以用于与来自患者样本的基因表达数据进行比较。可选择地，表达模式可以用不同的表现格式记录。图形记录是其中的一种。像整合在上述Partek公司的软件“DISCOVERY”和“INFER”中的聚类算法就能最好的协助显示这类数据。
本发明不同类型的制品是用来显示基因表达模式的介质或格式化检测。例如，这些可以包括微阵列，其中互补序列或探针被固定在基质上，当与目的基因的序列结合后能产生表示其存在的可读信号。可选择地，本发明的制品包括试剂盒，其能够进行杂交、扩增以及产生表明目的基因表达水平的信号以判断结肠直肠癌。
本发明制备的试剂盒包括用于测定基因表达模式的格式化检测。其中包括进行检测所需的全部或部分材料，例如试剂和操作指南。
本发明进一步用下列非限定性的实施例说明。
实施例本发明的基因分析典型地与编码蛋白或多肽产物的全长核酸序列相关。但本领域技术人员知道从分析的观点而言鉴定全长序列不是必需的。也就是说，根据公知的原则，部分序列或ESTs同样能够选作用来设计评估相应基因的基因表达的探针。
实施例1样本处理和LCM收集来自于外科切除结肠直肠癌肿瘤患者的新鲜冷冻组织样本。使用的样本来自63个根据标准诊断学和病理学被划分为Duck’s B期的患者。患者的临床结果是已知的。36名患者超过3年没有复发，而27名患者在3年内出现了肿瘤复发的情况。
在获得组织后的20-30分钟内快速用液氮将其冷冻，并且随后保存在-80℃的条件下。为了能够激光捕获，将样本切片(6μm)，其中一片封固于载玻片上，另一片封固于薄膜上(P.A.L.M.)，该薄膜已经被固定在载玻片上(Micro Slides Colorfrost，VWR Scientific，Media，PA)。封固于载玻片上的切片于冷的丙酮中固定，并且用Mayer’s苏木精(Sigma，St.Louis，MO)染色。病理学家通过分析样本进行诊断和分级。根据附带的外科病理学和临床报告进行临床分级评估以核实Dukes分类。封固于薄膜上的切片在100％的乙醇中固定5分钟，于曙红/100％乙醇(100μg曙红溶于100ml无水乙醇)中负染1分钟，在100％乙醇中快速浸泡一次以除去未结合的染料，空气中干燥10分钟。
用于LCM前，膜(LPC-MEMBRANE PEN FOIL 1.35μm No 8100，P.A.L.M.GmbH Mikrolaser Technologie，Bernried，Germany)和载玻片需进行预处理以除去RNA酶，并且增强组织样本在膜上的附着。简要地说，载玻片用DEP H2O洗涤，膜用RNase AWAY(Molecular Bioproducts，公司，SanDiego，CA)洗涤并在DEP H2O中漂洗。在将膜附着在载玻片以后，玻载片于+120℃烘烤8小时，用TI-SAD(Diagnostic Products Corporation，LosAngeles，CA，1∶50溶于DEP H2O中，脱脂棉花过滤)处理，+37℃温育30分钟。使用前，需在膜上封固组织样本的位置涂布10μl的RNA酶抑制溶液(Rnasin Inhibitor 2500U＝33U/μl N211A，Promega GmbH，Mannheim，Germany，0.5μl溶于400μl冰冷的溶液中，包括0.15mol NaCl，10mmol TrispH8.0，0.25mmol二硫苏糖醇)。
封固于膜上的组织切片用于进行LCM。使用PALM自动微光束技术(RA.LM.Mikrolaser Technologie，Carl Zeiss，公司，Thornwood，NY)，能够捕获大约2000个上皮细胞/样本，并连接到Zeisis Axiovert 135显微镜中(Carl ZeissJena GmbH，Jena，Germany)。其中包括正常粘膜的周围基质与癌症样本中偶然的干扰基质成分。捕获的细胞置于100％乙醇的小管中于-80℃保存。
实施例2RNA提取与扩增使用Zymo-Spin Column(Zymo Research，Orange，CA 92867)从LCM捕获的样本中提取总RNA。大约2ng的总RNA重悬于10μl水中，并使用T7RNA聚合酶进行2轮扩增，从而获得大约50μg的扩增RNA。
实施例3DNA微阵列杂交与定量用可商购的Affymetrix公司的人U133a，通过由大约23,000个人DNA克隆组成的一组DNA微阵列测定样本。根据前述方法制备并获得的总RNA用于所述芯片，使用Agilent BioAnalyzer参照产品说明书进行分析。所有63个样本均符合质量控制标准，并且其数据被用于标记的选择。
芯片强度数据通过Affymetrix公司的软件MAS VERSION 5.0进行分析。通过自动的分析确定了两个能够用以区分复发患者与不复发患者的基因。
上述获得的芯片强度数据作为PARTEK 5.1等商业自动聚类软件的输入值。使用该自动聚类算法识别有20个患者的高复发率群体(13个复发，7个存活)。从最初的23,000个基因中，t检验分析选出了276个在这些病人中显著差异表达的基因。其中，两个基因能够最好地区分复发患者与不复发患者人肠肽相关转运蛋白(Seq.ID.No.3)和人脂肪酸结合蛋白1(Seq.ID No.1)。这两个基因在该患者群体中的复发患者中下调(实际上是被关闭或是没有表达)。
在余下的43名患者中采用手动分析以进一步的区分复发患者与不复发患者。这组患者的数据被进一步分为以下两组27名患者被分到训练组，16名患者被分到测试组。这保证了不会将相同的数据同时用于确定标记和检验标记的效用。
不等方差t检验用于训练组。从具有有效的校正p值的28个基因中选出MHC II-DR-B。这些基因在复发患者中下调。MHC II-DR-B(Seq.IDNo.2)也具有最小的p值。
在另一轮的手动分析过程中，使用上述的Partek Version 5.0软件运行变量选择程序进行线性鉴别分析以区分训练组的存活和复发患者。搜寻的方法采用预选。用最小后验误差选择的变量为免疫球蛋白样转录物5蛋白(Seq.ID No.4)。Cox比例风险模型(使用Insightful公司的“S Plus”软件)用于基因选择以确定上述基因选择的存活时间。在全部27轮的每一轮中，训练组中27个患者中的一个被取出，剩下的26个患者被用于单变量Cox模型回归以评估基因表达与患者存活时间之间的关联度。该关联度由从Cox模型回归返回的相应的标准参数估计值和P值评估。0.01的P值作为界限用来从每一轮排除一个样本的基因选择中选取上基因(top gene)。比较每一轮挑选出的上基因(top gene)，选出在全部27轮排除一个基因的选择循环中至少有26次被选中的基因。总共70个基因被选出，并且MHC II-DR-B与免疫球蛋白样转录物5蛋白均在其中(又显示为下调)。
构建多基因预测因子MHC II-DR-B与免疫球蛋白样转录物5蛋白这两个基因用于通过线性鉴别分析产生预测因子。投票值表示复发的后验概率。当患者的值大于0.5时被认为是复发患者。当患者的值小于于0.5时则被认为是存活患者。该预测因子在训练组中进行测验。
交叉确认和预测因子评估预测因子的性能将在独立的数据组中进行测定，因为多数的分类方法均在构建它的实例中效果良好。16名患者的测试组用来评估预测的准确性。分类的中止由ROC曲线来决定。选择中止后，将确定测试组中准确预测的复发和存活患者数量。
全面预测对63个Duke’s B期结肠癌患者的基因表达模式进行分析，确定了在患者中差异表达的4个基因(下调或关闭)。这些基因是Seq.IDNo.1，Seq.ID No.2，Seq.ID No.3和Seq.ID No.4。36名患者在3年以上病情没有复发，而27名患者在3年内肿瘤复发。使用Seq.ID No.2，Seq.ID No.3和Seq.ID No.4这3个基因标记组合进行预测，27个复发患者中的22个以及36个存活患者中的27个能够被正确的确定。这一结果显示了82％的灵敏度和75％的特异性。阳性预测值为71％，阴性预测值为84％。
实施例4更多的样本对74名已编号的Dukes’B结肠癌患者的冰冻肿瘤样本进行研究。外科手术时收集原发肿瘤以及附近无瘤结肠组织。对每个样本重新进行组织病理学分析以确定诊断结果以及肿瘤累及的一致性。选择用于分析的区域包含超过50％的肿瘤细胞结构并且没有混入其它组织。还可以获得一致性的后续信息。
实施例5基因表达分析根据实施例1-3中描述的方法从实施例4的样本中提取总RNA。阵列用标准的Affymetrix方法和扫描仪进行扫描。为了进行后续分析，每个探针组被当作一个分离的基因。通过Affymetrix GeneChip分析软件MAS 5.0计算每个基因的表达值。所有用于后续分析的数据均符合质量控制标准。
统计学方法基因表达数据首先通过变量筛选以除去在所有样本中均“不存在”的基因。在22,000个基因中，17,616个基因通过了筛选用于聚类。在分级聚类前，每个基因根据患者的中间表达水平进行划分。在至少10％患者中的表达水平超过平均表达水平4倍以上变化的基因用于聚类。为了确定具有不同基因表达模式的子患者群，分别使用软件GeneSpring 5.0(SanJose，CA)和Partek 5.1(St.Louis，MO)进行平均连锁分级聚类和k平均值聚类。使用经过Bonferroni修正的T检验，根据聚类结果识别在两个子患者群中具有不同表达水平的基因。Bonferroni修正P值为0.01被选作基因选择的界限。每类中具有不同表达模式的患者将进一步根据输出信息进行检查。
为了鉴定能够区分复发患者和存活患者的基因标记，每个子患者群分开进行下面的分析。所有的统计学分析都是通过软件S-Plus(Insightful，VA)进行的。
患者与肿瘤性质表1中列出了患者的临床和病理学特征以及肿瘤的情况。包括的信息有患者的年龄、性别、TNM阶段、等级、肿瘤大小和肿瘤的位置。74名患者中有73名有测定的淋巴结数量的数据，74名患者中有72名有估计的肿瘤大小信息。复发患者与存活患者间在病情和肿瘤特征方面没有显著差异。没有患者接受过手术前治疗。研究中所有的患者都具有接下来最少3年的病情数据。
根据基因表达模式鉴定子患者群自动分级聚类分析根据17,000个主要基因的表达模式相似性生成了含有74名患者的群。其中确定了两个子患者群，子群间有超过600个差异表达的基因(p＜0.00001)。较大的子群和较小的子群分别包括54名和20名患者。在含有54名患者的较大子群中仅有18名患者(33％)在3年内肿瘤复发，而在含有20名患者的较小子群中有13名患者(65％)出现了后续病变。卡方分析给出了0.028的p值。
筛选和检测出了两个主要的基因群，其在两类肿瘤间有明显不同的表达。第一个基因群在20名患者的较小子群中含有一组下调的基因，例如肝肠特异性钙粘着蛋白17、脂肪酸结合蛋白1、尾类同源框转录因子(caudaltype homeo box transcription factor)CDX1和CDX2、粘蛋白和类钙粘着蛋白MUCDHL。第二个基因群以一组在较小患者子群中上调的基因为代表，包括血清诱导激酶SNK、膜联蛋白A1、B细胞RAG相关蛋白、钙结合蛋白2和肿瘤抗原L6。有20名患者较小的的子群根据基因表达模式代表低分化的肿瘤。
基因信号及其预测值为了鉴定能够区分复发患者与存活患者的基因标记，分别单独分析每个患者子群。每个子群的患者首先被分为训练组和测试组，两组中患者的数量大致相同。训练组用于筛选基因标记并且建立预后信号。测试组用于进行独立的检验。在含有54名患者的较大子群中，有36名患者在首次诊断后至少3年没有复发，而18名患者在3年内出现了肿瘤复发。这54名患者被分为两组。训练组中含有21名存活患者和6名复发患者。在较小的含有20名患者的子群中，7名患者在至少3年内没有复发和13名患者在3年内出现肿瘤复发。这20名患者被分为两组。训练组中含有4名存活患者和7名复发患者。为了确定一个基因信号以区分预后良好的群体和预后不良的群体，手动的分类方法应用于每个训练组。单变量Cox比例风险回归被用来确定表达水平与患者存活时间相关的基因。基因的选择以p值小于0.02为选择标准。然后，对选择的基因进行t检验以测定在复发患者和存活患者间差异表达的显著性(P＜0.01>。为了避免选择的基因只适合该训练组，重新取样100次进行t检验以找到在超过80％的重新取样测试中具有显著p值的基因。在含有27名患者的训练组中选出了7个基因(表2)，在含有11名患者的训练组中选出了15个基因(表3)。根据这22个基因和钙粘着蛋白17，用S-Plus软件构建Cox模型来预测患者的复发情况。Kaplan-Meier存活分析显示，预测为预后良好的群体与预测为预后不良的群体间患者存活的概率存在明显的差异。
其中几个基因与细胞增殖和肿瘤发生有关。例如，酪氨酸3单加氧酶色氨酸5单加氧酶激活蛋白(YWHAH)属于14-3-3蛋白家族，其与人类细胞DNA损伤后的G2细胞周期控制有关。RCC1是另一个细胞周期基因，其参与调控染色体凝聚的启动。BTEB2是一种锌指转录因子，其被认为是β连环蛋白不依赖的Wnt-1应答基因。少量基因可能参与局部免疫应答。免疫球蛋白样转录物5蛋白是一种常见的MHC I分子抑制受体。CAPG是凝溶胶蛋白/绒毛蛋白家族帽状蛋白的唯一成员，其主要在巨噬细胞中表达。LAT是高酪氨酸磷酸化蛋白，其连接T细胞受体导致细胞活化。这样肿瘤细胞和免疫细胞表达的基因均可作为预测因子来判断患者的复发情况。
为了检验23-基因的预后信号，将27名患者的较大子群和9名患者的较小子群的两个测试组的患者被合并在一起，所做的预测结果均是根据测试组中这36名独立患者作出的。该测试组中包括18名在3年内肿瘤复发的患者和18名3年以上没有复发的患者。预测的结果是有13个正确的复发分类和15个正确的存活分类。整体的准确率为78％(36名中的28名)，其中灵敏度为72％(18名中的13名)，特异性为83％(18名中的15名)。这一性能显示在Dukes’B期患者中，测量值低于预后信号极限的患者在3年内肿瘤复发的概率比测量值高于预后信号极限的患者高13倍(95％CI:2.6，65；P＝0.003)。此外，Kaplan-Meier存活分析显示，预测为预后良好的群体与预测为预后不良的群体间患者存活的概率存在显著差异(P＜0.0001)。在多变量Cox比例风险回归中，肿瘤复发的估计风险率为0.41(95％置信区间，0.24到0.71；P＝0.001)表明23-基因组代表了预后信号，而且它与更高的肿瘤复发率负相关。使用含有7个基因的组合(表2)，可以得到83％的灵敏度和80％的特异性(根据12个复发者和15个存活者的样本组)。使用含有15个基因的组合(表3)，可以得到50％的灵敏度和100％的特异性(根据6个复发者和3个存活者的样本组)。图1和2图形显示了分别对含7基因组合和15基因组合进行Kaplan-Meier分析的图形描述。
此外，如这些结果所示，可以通过分析原发肿瘤的基因表达模式进行预后判断。
表1.患者及其肿瘤的临床和病理学特征特征存活 复发P值*患者比例(％)年龄4331 0.7649平均值 58.93 58.06性别4331 0.8778女 23(53)18(58)男 20(47)13(42)T阶段 4331 0.20352 12(28)5(16)3 29(67)26(84)4 2(5) 0(0)分化4331 0.4082差 5(12) 6(19)中 37(86)23(74)好 1(2) 2(6)肿瘤大小41310.1575＜5 29(71)16(52)＞＝5 12(29)15(48)位置4331 0.7997LC 1(2) 1(3)RC 17(40)10(32)TC 6(14) 3(10)SC 19(44)17(55)检查到的LN数量 4330 0.0456平均值 12.81 8.63*年龄、淋巴结数量和肿瘤信息的P值是通过t检验获得的；其他的P值是通过χ2检验得到。
表27基因列表登录号Seq.ID No.
AF009643.17NM_003405.1 8X06130.1 9AB030824.110NM_001747.1 11AF036906.112BC005286.113表315基因列表
表4.23个基因构成的预测信号改变方向 Seq.ID No. P值 基因描述(Cox)- 7 0.0011 免疫球蛋白样转录物5蛋白- 8 0.0016 酪氨酸3单加氧酶色氨酸5单加氧酶激活蛋白- 9 0.0024 细胞周期基因RCC1+ 10 0.0027 转录因子BTEB2- 11 0.0045 帽状蛋白(肌动蛋白丝)，凝溶胶蛋白一样(CAPG)- 12 0.0012 激活T细胞的接头(LAT)- 13 0.0046 Lafora病(laforin)- 14 0.0110 核脆性X智力迟钝蛋白作用蛋白1(NUFIP1)+ 15 解离素样和金属蛋白酶(reprolysin型)与血小板0.0126 反应蛋白型1基序，12(ADAMTS12)+ 16 0.0126 G抗原4(GAGE4)+ 17 0.0130 包括粘蛋白样受体EMR3的EGF的分子+ 18 0.0131 丙氨酸乙醛酸转氨酶+ 19 0.0131 肽基精氨酸deiminase，V类(PAD)+ 20 0.0136 钾内调通道，K亚家族，成员4(KCNK4)+ 21 0.0139 KIAA0125基因产物+ 22 0.0142 假定蛋白FLJ20712(FLJ20712)+ 23 0.0145 载脂蛋白C-I(APOC1)+ 24 0.0146 包括gbAL545035的共有序列+ 25 0.0149 假定蛋FLJ12455(FLJ12455)+ 26 0.0150 包括gbAL133089.1的共有序列+ 27 0.0151 染色体解旋酶DNA结合蛋白2(CHD2)+ 28 0.0152 包括gbAL137428.1的公有序列N/A 6 未测 钙粘着蛋白17
序列表<110>奥索临床诊断有限公司Wang，Yixin<120>结肠直肠癌预后<130>ADS-5003 US NP<140>tbd<141>2003-08-27<160>94<170>PatentIn version 3.1<210>1<211>489<212>DNA<213>人<400>1agagccgcag gtcagtcgtg aagagggagc tctattgcca ccatgagttt ctccggcaag 60taccaactgc agagccagga aaactttgaa gccttcatga aggcaatcgg tctgccggaa 120gagctcatcc agaaggggaa ggatatcaag ggggtgtcgg aaatcgtgca gaatgggaag 180cacttcaagt tcaccatcac cgctgggtcc aaagtgatcc aaaacgaatt cacggtgggg 240gaggaatgtg agctggagac aatgacaggg gagaaagtca agacagtggt tcagttggaa 300ggtgacaata aactggtgac aactttcaaa aacatcaagt ctgtgaccga actcaacggc 360gacataatca ccaataccat gacattgggt gacattgtct tcaagagaat cagcaagaga 420atttaaacaa gtctgcattt catattattt tagtgtgtaa aattaatgta ataaagtgaa 480ctttgtttt 489<210>2<211>853<212>DNA<213>人<400>2gcctgctgct ctggcccctg gtcctgtcct gttctccagc atggtgtgtc tgaggctccc 60tggaggctcc tgcatggcag ttctgacagt gacactgatg gtgctgagct ccccactggc 120tttggctggg gacaccagac cacgtttctt ggagtactct acgtctgagt gtcatttctt 180
caatgggacg gagcgggtgc ggtacctgga cagatacttc cataaccagg aggagaacgt240gcgcttcgac agcgacgtgg gggagttccg ggcggtgacg gagctggggc ggcctgctgc300ggagcactgg aacagccaga aggacctcct ggagcagaag cggggccggg tggacaacta360ctgcagacac aactacgggg ttgtggagag cttcacagtg cagcggcgag tccatcctaa420ggtgactgtg tatccttcaa agacccagcc cctgcagcac cataacctcc tggtctgttc480tgtgagtggt ttctatccag gcagcattga agtcaggtgg ttccggaatg gccaggaaga540gaagactggg gtggtgtcca caggcctgat ccacaatgga gactggacct tccagaccct600ggtgatgctg gaaacagttc ctcggagtgg agaggtttac acctgccaag tggagcaccc660aagcgtgaca agccctctca cagtggaatg gagagcacgg tctgaatctg cacagagcaa720gatgctgagt ggagtcgggg gctttgtgct gggcctgctc ttccttgggg ccgggctgtt780catctacttc aggaatcaga aaggacactc tggacttcag ccaagaggat tcctgagctg840aagtgcagat gac 853<210>3<211>3345<212>DNA<213>人<400>3gaattccgtc tcgaccactg aatggaagaa aaggactttt aaccaccatt ttgtgactta 60cagaaaggaa tttgaataaa gaaaactatg atacttcagg cccatcttca ctccctgtgt120cttcttatgc tttatttggc aactggatat ggccaagagg ggaagtttag tggacccctg180aaacccatga cattttctat ttatgaaggc caagaaccga gtcaaattat attccagttt240aaggccaatc ctcctgctgt gacttttgaa ctaactgggg agacagacaa catatttgtg300atagaacggg agggacttct gtattacaac agagccttgg acagggaaac aagatctact360cacaatctcc aggttgcagc cctggacgct aatggaatta tagtggaggg tccagtccct420atcaccatag aagtgaagga catcaacgac aatcgaccca cgtttctcca gtcaaagtac480gaaggctcag taaggcagaa ctctcgccca ggaaagccct tcttgtatgt caatgccaca540gacctggatg atccggccac tcccaatggc cagctttatt accagattgt catccagctt600cccatgatca acaatgtcatg tactttcag atcaacaaca aaacgggagc catctctctt660acccgagagg gatctcagga attgaatcct gctaagaatc cttcctataa tctggtgatc720tcagtgaagg acatgggagg ccagagtgag aattccttca gtgataccac atctgtggat780
atcatagtga cagagaatat ttggaaagca ccaaaacctg tggagatggt ggaaaactca840actgatcctc accccatcaa aatcactcag gtgcggtgga atgatcccgg tgcacaatat900tccttagttg acaaagagaa gctgccaaga ttcccatttt caattgacca ggaaggagat960atttacgtga ctcagccctt ggaccgagaa gaaaaggatg catatgtttt ttatgcagtt 1020gcaaaggatg agtacggaaa accactttca tatccgctgg aaattcatgt aaaagttaaa 1080gatattaatg ataatccacc tacatgtccg tcaccagtaa ccgtatttga ggtccaggag 1140aatgaacgac tgggtaacag tatcgggacc cttactgcac atgacaggga tgaagaaaat 1200actgccaaca gttttctaaa ctacaggatt gtggagcaaa ctcccaaact tcccatggat 1260ggactcttcc taatccaaac ctatgctgga atgttacagt tagctaaaca gtccttgaag 1320aagcaagata ctcctcagta caacttaacg atagaggtgt ctgacaaaga tttcaagacc 1380ctttgttttg tgcaaatcaa cgttattgat atcaatgatc agatccccat ctttgaaaaa 1440tcagattatg gaaacctgac tcttgctgaa gacacaaaca ttgggtccac catcttaacc 1500atccaggcca ctgatgctga tgagccattt actgggagtt ctaaaattct gtatcatatc 1560ataaagggag acagtgaggg acgcctgggg gttgacacag atccccatac caacaccgga 1620tatgtcataa ttaaaaagcc tcttgatttt gaaacagcag ctgtttccaa cattgtgttc 1680aaagcagaaa atcctgagcc tctagtgttt ggtgtgaagt acaatgcaag ttcttttgcc 1740aagttcacgc ttattgtgac agatgtgaat gaagcacctc aattttccca acacgtattc 1800caagcgaaag tcagtgagga tgtagctata ggcactaaag tgggcaatgt gactgccaag 1860gatccagaag gtctggacat aagctattca ctgaggggag acacaagagg ttggcttaaa 1920attgaccacg tgactggtga gatctttagt gtggctccat tggacagaga agccggaagt 1980ccatatcggg tacaagtggt ggccacagaa gtaggggggt cttccttaag ctctgtgtca 2040gagttccacc tgatccttat ggatgtgaat gacaaccctc ccaggctagc caaggactac 2100acgggcttgt tcttctgcca tcccctcagt gcacctggaa gtctcatttt cgaggctact 2160gatgatgatc agcacttatt tcggggtccc cattttacat tttccctcgg cagtggaagc 2220ttacaaaacg actgggaagt ttccaaaatc aatggtactc atgcccgact gtctaccagg 2280cacacagact ttgaggagag ggcgtatgtc gtcttgatcc gcatcaatga tgggggtcgg 2340ccacccttgg aaggcattgt ttctttacca gttacattct gcagttgtgt ggaaggaagt 2400tgtttccggc cagcaggtca ccagactggg atacccactg tgggcatggc agttggtata 2460
ctgctgacca cccttctggt gattggtata attttagcag ttgtgtttat ccgcataaag 2520aaggataaag gcaaagataa tgttgaaagt gctcaagcat ctgaagtcaa acctctgaga 2580agctgaattt gaaaaggaat gtttgaattt atatagcaag tgctatttca gcaacaacca 2640tctcatccta ttacttttca tctaacgtgc attataattt tttaaacaga tattccctct 2700tgtcctttaa tatttgctaa atatttcttt tttgaggtgg agtcttgctc tgtcgcccag 2760gctggagtac agtggtgtga tcccagctca ctgcaacctc cgcctcctgg gttcacatga 2820ttctcctgcc tcagcttcct aagtagctgg gtttacaggc acccaccacc atgcccagct 2880aatttttgta tttttaatag agacggggtt tcgccatttg gccaggctgg tcttgaactc 2940ctgacgtcaa gtgatctgcc tgccttggtc tcccaataca ggcatgaacc actgcaccca 3000cctacttaga tatttcatgt gctatagaca ttagagagat ttttcatttt tccatgacat 3060ttttcctctc tgcaaatggc ttagctactt gtgtttttcc cttttggggc aagacagact 3120cattaaatat tctgtacatt ttttctttat caaggagata tatcagtgtt gtctcataga 3180actgcctgga ttccatttat gttttttctg attccatcct gtgtcccctt catccttgac 3240tcctttggta tttcactgaa tttcaaacat ttgtcagaga agaaaaaagt gaggactcag 3300gaaaaataaa taaataaaag aacagccttt tgcggccgcg aattc 3345<210>4<211>1924<212>DNA<213>人<400>4ccatgacgcc cgccctcaca gccctgctct gccttgggct gagtctgggc cccaggaccc 60gcatgcaggc agggcccttc cccaaaccca ccctctgggc tgagccaggc tctgtgatca120gctgggggag ccccgtgacc atctggtgtc aggggagcct ggaggcccag gagtaccaac180tggataaaga gggaagccca gagccctggg acagaaataa cccactggaa cccaagaaca240aggccagatt ctccatccca tccatgacac agcaccatgc agggagatac cgctgccact300attacagctc tgcaggctgg tcagagccca gcgaccccct ggagctggtg atgacaggat360tctacaacaa acccaccctc tcagccctgc ccagccctgt ggtggcctca ggggggaata420tgaccctccg atgtggctca cagaagggat atcaccattt tgttctgatg aaggaaggag480aacaccagct cccccggacc ctggactcac agcagctcca cagtgggggg ttccaggccc540tgttccctgt gggccccgtg acccccagcc acaggcgtgt ctaggaagcc ctccctcctg600
accctgcagg gccctgtcct ggcccctggg cagagcctga ccctccagtg tggctctgat660gtcggctacg acagatttgt tctgtataag gagggggaac gtgacttcct ccagcgccct720ggccagcagc cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc780tcctacgggg gccagtacag gtgctatggt gcacacaacc tctcctccga gtggtcggcc840cccagtgacc ccctggacat cctgatcaca ggacagatct atgacaccgt ctccctgtca900gcacagccgg gccccacagt ggcctcagga gagaacatga ccctgctgtg tcagtcacgg960gggtattttg acactttcct tctgaccaaa gaaggggcag cccatccccc actgcgtctg 1020agatcaatgt acggagctca taagtaccag gctgaattcc ccatgagtcc tgtgacctca 1080gcccacgcgg ggacctacag gtgctacggc tcacgcagct ccaaccccca cctgctgtct 1140ttccccagtg agcccctgga actcatggtc tcaggacact ctggaggctc cagcctccca 1200cccacagggc cgccctccac acctggtctg ggaagatacc tggaggtttt gattggggtc 1260tcggtggcct tcgtcctgct gctcttcctc ctcctcttcc tcctcctccg acgtcagcgt 1320cacagcaaac acaggacatc tgaccagaga aagactgatt tccagcgtcc tgcaggggct 1380gcggagacag agcccaagga caggggcctg ctgaggaggt ccagcccagc tgctgacgtc 1440caggaagaaa acctctagcc cacacgatga agacccccag gcagtgacgt atgccccggt 1500gaaacactcc agtcctagga gagaaatggc ctctcctccc tcctcactgt ctggggaatt 1560cctggacaca aaggacagac aggtggaaga ggacaggcag atggacactg aggctgctgc 1620atctgaagcc tcccaggatg tgacctacgc ccagctgcac agcttgaccc ttagacggaa 1680ggcaactgag cctcctccat cccaggaagg ggaacctcca gctgagccca gcatctacgc 1740cactctggcc atccactagc ccggggggta cgcagacccc acactcagca gaaggagact 1800caggactgct gaaggcacgg gagctgcccc cagtggacac cagtgaaccc cagtcagcct 1860ggacccctaa cacagaccat gaggagacgc tgggaacttg tgggactcac ctgactcaaa 1920gatg1924<210>5<211>1536<212>DNA<213>人<400>5gtgacgcgag gctctgcgga gaccaggagt cagactgtag gacgacctcg ggtcccacgt 60gtccccggta ctcgccggcc ggagcccccg gcttcccggg gccgggggac cttagcggca120
cccacacaca gcctactttc caagcggagc catgtctggt aacggcaatg cggctgcaac180ggcggaagaa aacagcccaa agatgagagt gattcgcgtg ggtacccgca agagccagct240tgctcgcata cagacggaca gtgtggtggc aacattgaaa gcctcgtacc ctggcctgca300gtttgaaatc attgctatgt ccaccacagg ggacaagatt cttgatactg cactctctaa360gattggagag aaaagcctgt ttaccaagga gcttgaacat gccctggaga agaatgaagt420ggacctggtt gttcactcct tgaaggacct gcccactgtg cttcctcctg gcttcaccat480cggagccatc tgcaagcggg aaaaccctca tgatgctgtt gtctttcacc caaaatttgt540tgggaagacc ctagaaaccc tgccagagaa gagtgtggtg ggaaccagct ccctgcgaag600agcagcccag ctgcagagaa agttcccgca tctggagttc aggagtattc ggggaaacct660caacacccgg cttcggaagc tggacgagca gcaggagttc agtgccatca tcctggcaac720agctggcctg cagcgcatgg gctggcacaa ccgggtgggg cagatcctgc accctgagga780atgcatgtat gctgtgggcc agggggcctt gggcgtggaa gtgcgagcca aggaccagga840catcttggat ctggtgggtg tgctgcacga tcccgagact ctgcttcgct gcatcgctga900aagggccttc ctgaggcacc tggaaggagg ctgcagtgtg ccagtagccg tgcatacagc960tatgaaggat gggcaactgt acctgactgg aggagtctgg agtctagacg gctcagatag 1020catacaagag accatgcagg ctaccatcca tgtccctgcc cagcatgaag atggccctga 1080ggatgaccca cagttggtag gcatcactgc tcgtaacatt ccacgagggc cccagttggc 1140tgcccagaac ttgggcatca gcctggccaa cttgttgctg agcaaaggag ccaaaaacat 1200cctggatgtt gcacggcagc ttaacgatgc ccattaactg gtttgtgggg cacagatgcc 1260tgggttgctg ctgtccagtg cctacatccc gggcctcagt gccccattct cactgctatc 1320tggggagtga ttaccccggg agactgaact gcagggttca agccttccag ggatttgcct 1380caccttgggg ccttgatgac tgccttgcct cctcagtatg tgggggcttc atctctttag 1440agaagtccaa gcaacagcct ttgaatgtaa ccaatcctac taataaacca gttctgaagg 1500taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1536<210>6<211>3345<212>DNA<213>人<400>6gaattccgtc tcgaccactg aatggaagaa aaggactttt aaccaccatt ttgtgactta 60
cagaaaggaa tttgaataaa gaaaactatg atacttcagg cccatcttca ctccctgtgt120cttcttatgc tttatttggc aactggatat ggccaagagg ggaagtttag tggacccctg180aaacccatga cattttctat ttatgaaggc caagaaccga gtcaaattat attccagttt240aaggccaatc ctcctgctgt gacttttgaa ctaactgggg agacagacaa catatttgtg300atagaacggg agggacttct gtattacaac agagccttgg acagggaaac aagatctact360cacaatctcc aggttgcagc cctggacgct aatggaatta tagtggaggg tccagtccct420atcaccatag aagtgaagga catcaacgac aatcgaccca cgtttctcca gtcaaagtac480gaaggctcag taaggcagaa ctctcgccca ggaaagccct tcttgtatgt caatgccaca540gacctggatg atccggccac tcccaatggc cagctttatt accagattgt catccagctt600cccatgatca acaatgtcat gtactttcag atcaacaaca aaacgggagc catctctctt660acccgagagg gatctcagga attgaatcct gctaagaatc cttcctataa tctggtgatc720tcagtgaagg acatgggagg ccagagtgag aattccttca gtgataccac atctgtggat780atcatagtga cagagaatat ttggaaagca ccaaaacctg tggagatggt ggaaaactca840actgatcctc accccatcaa aatcactcag gtgcggtgga atgatcccgg tgcacaatat900tccttagttg acaaagagaa gctgccaaga ttcccatttt caattgacca ggaaggagat960atttacgtga ctcagccctt ggaccgagaa gaaaaggatg catatgtttt ttatgcagtt 1020gcaaaggatg agtacggaaa accactttca tatccgctgg aaattcatgt aaaagttaaa 1080gatattaatg ataatccacc tacatgtccg tcaccagtaa ccgtatttga ggtccaggag 1140aatgaacgac tgggtaacag tatcgggacc cttactgcac atgacaggga tgaagaaaat 1200actgccaaca gttttctaaa ctacaggatt gtggagcaaa ctcccaaact tcccatggat 1260ggactcttcc taatccaaac ctatgctgga atgttacagt tagctaaaca gtccttgaag 1320aagcaagata ctcctcagta caacttaacg atagaggtgt ctgacaaaga tttcaagacc 1380ctttgttttg tgcaaatcaa cgttattgat atcaatgatc agatccccat ctttgaaaaa 1440tcagattatg gaaacctgac tcttgctgaa gacacaaaca ttgggtccac catcttaacc 1500atccaggcca ctgatgctga tgagccattt actgggagtt ctaaaattct gtatcatatc 1560ataaagggag acagtgaggg acgcctgggg gttgacacag atccccatac caacaccgga 1620tatgtcataa ttaaaaagcc tcttgatttt gaaacagcag ctgtttccaa cattgtgttc 1680aaagcagaaa atcctgagcc tctagtgttt ggtgtgaagt acaatgcaag ttcttttgcc 1740aagttcacgc ttattgtgac agatgtgaat gaagcacctc aattttccca acacgtattc 1800
caagcgaaag tcagtgagga tgtagctata ggcactaaag tgggcaatgt gactgccaag 1860gatccagaag gtctggacat aagctattca ctgaggggag acacaagagg ttggcttaaa 1920attgaccacg tgactggtga gatctttagt gtggctccat tggacagaga agccggaagt 1980ccatatcggg tacaagtggt ggccacagaa gtaggggggt cttccttaag ctctgtgtca 2040gagttccacc tgatccttat ggatgtgaat gacaaccctc ccaggctagc caaggactac 2100acgggcttgt tcttctgcca tcccctcagt gcacctggaa gtctcatttt cgaggctact 2160gatgatgatc agcacttatt tcggggtccc cattttacat tttccctcgg cagtggaagc 2220ttacaaaacg actgggaagt ttccaaaatc aatggtactc atgcccgact gtctaccagg 2280cacacagact ttgaggagag ggcgtatgtc gtcttgatcc gcatcaatga tgggggtcgg 2340ccacccttgg aaggcattgt ttctttacca gttacattct gcagttgtgt ggaaggaagt 2400tgtttccggc cagcaggtca ccagactggg atacccactg tgggcatggc agttggtata 2460ctgctgacca cccttctggt gattggtata attttagcag ttgtgtttat ccgcataaag 2520aaggataaag gcaaagataa tgttgaaagt gctcaagcat ctgaagtcaa acctctgaga 2580agctgaattt gaaaaggaat gtttgaattt atatagcaag tgctatttca gcaacaacca 2640tctcatccta ttacttttca tctaacgtgc attataattt tttaaacaga tattccctct 2700tgtcctttaa tatttgctaa atatttcttt tttgaggtgg agtcttgctc tgtcgcccag 2760gctggagtac agtggtgtga tcccagctca ctgcaacctc cgcctcctgg gttcacatga 2820ttctcctgcc tcagcttcct aagtagctgg gtttacaggc acccaccacc atgcccagct 2880aatttttgta tttttaatag agacggggtt tcgccatttg gccaggctgg tcttgaactc 2940ctgacgtcaa gtgatctgcc tgccttggtc tcccaataca ggcatgaacc actgcaccca 3000cctacttaga tatttcatgt gctatagaca ttagagagat ttttcatttt tccatgacat 3060ttttcctctc tgcaaatggc ttagctactt gtgtttttcc cttttggggc aagacagact 3120cattaaatat tctgtacatt ttttctttat caaggagata tatcagtgtt gtctcataga 3180actgcctgga ttccatttat gttttttctg attccatcct gtgtcccctt catccttgac 3240tcctttggta tttcactgaa tttcaaacat ttgtcagaga agaaaaaagt gaggactcag 3300gaaaaataaa taaataaaag aacagccttt tgcggccgcg aattc 3345<210>7<211>1924<212>DNA
<213>人<400>7ccatgacgcc cgccctcaca gccctgctct gccttgggct gagtctgggc cccaggaccc 60gcatgcaggc agggcccttc cccaaaccca ccctctgggc tgagccaggc tctgtgatca120gctgggggag ccccgtgacc atctggtgtc aggggagcct ggaggcccag gagtaccaac180tggataaaga gggaagccca gagccctggg acagaaataa cccactggaa cccaagaaca240aggccagatt ctccatccca tccatgacac agcaccatgc agggagatac cgctgccact300attacagctc tgcaggctgg tcagagccca gcgaccccct ggagctggtg atgacaggat360tctacaacaa acccaccctc tcagccctgc ccagccctgt ggtggcctca ggggggaata420tgaccctccg atgtggctca cagaagggat atcaccattt tgttctgatg aaggaaggag480aacaccagct cccccggacc ctggactcac agcagctcca cagtgggggg ttccaggccc540tgttccctgt gggccccgtg acccccagcc acaggcgtgt ctaggaagcc ctccctcctg600accctgcagg gccctgtcct ggcccctggg cagagcctga ccctccagtg tggctctgat660gtcggctacg acagatttgt tctgtataag gagggggaac gtgacttcct ccagcgccct720ggccagcagc cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc780tcctacgggg gccagtacag gtgctatggt gcacacaacc tctcctccga gtggtcggcc840cccagtgacc ccctggacat cctgatcaca ggacagatct atgacaccgt ctccctgtca900gcacagccgg gccccacagt ggcctcagga gagaacatga ccctgctgtg tcagtcacgg960gggtattttg acactttcct tctgaccaaa gaaggggcag cccatccccc actgcgtctg 1020agatcaatgt acggagctca taagtaccag gctgaattcc ccatgagtcc tgtgacctca 1080gcccacgcgg ggacctacag gtgctacggc tcacgcagct ccaaccccca cctgctgtct 1140ttccccagtg agcccctgga actcatggtc tcaggacact ctggaggctc cagcctccca 1200cccacagggc cgccctccac acctggtctg ggaagatacc tggaggtttt gattggggtc 1260tcggtggcct tcgtcctgct gctcttcctc ctcctcttcc tcctcctccg acgtcagcgt 1320cacagcaaac acaggacatc tgaccagaga aagactgatt tccagcgtcc tgcaggggct 1380gcggagacag agcccaagga caggggcctg ctgaggaggt ccagcccagc tgctgacgtc 1440caggaagaaa acctctagcc cacacgatga agacccccag gcagtgacgt atgccccggt 1500gaaacactcc agtcctagga gagaaatggc ctctcctccc tcctcactgt ctggggaatt 1560cctggacaca aaggacagac aggtggaaga ggacaggcag atggacactg aggctgctgc 1620
atctgaagcc tcccaggatg tgacctacgc ccagctgcac agcttgaccc ttagacggaa 1680ggcaactgag cctcctccat cccaggaagg ggaacctcca gctgagccca gcatctacgc 1740cactctggcc atccactagc ccggggggta cgcagacccc acactcagca gaaggagact 1800caggactgct gaaggcacgg gagctgcccc cagtggacac cagtgaaccc cagtcagcct 1860ggacccctaa cacagaccat gaggagacgc tgggaacttg tgggactcac ctgactcaaa 1920gatg1924<210>8<211>1775<212>DNA<213>人<400>8agcggccggg gcgagccagc gagagggcgc gagcggcggc gctgcctgca gcctgcagcc 60tgcagcctcc ggccggccgg cgagccagtg cgcgtgcgcg gcggcggcct ccgcagcgac120cggggagcgg actgaccggc gggagggcta gcgagccagc ggtgtgaggc gcgaggcgag180gccgagccgc gagcgacatg ggggaccggg agcagctgct gcagcgggcg cggctggccg240agcaggcgga gcgctacgac gacatggcct ccgctatgaa ggcggtgaca gagctgaatg300aacctctctc caatgaagat cgaaatctcc tctctgtggc ctacaagaat gtggttggtg360ccaggcgatc ttcctggagg gtcattagca gcattgagca gaaaaccatg gctgatggaa420acgaaaagaa attggagaaa gttaaagctt accgggagaa gattgagaag gagctggaga480cagtttgcaa tgatgtcctg tctctgcttg acaagttcct gatcaagaac tgcaatgatt540tccagtatga gagcaaggtg ttttacctga aaatgaaggg tgattactac cgctacttag600cagaggtcgc ttctggggag aagaaaaaca gtgtggtcga agcttctgaa gctgcctaca660aggaagcctt tgaaatcagc aaagagcaga tgcaacccac gcatcccatc cggctgggcc720tggccctcaa cttctccgtg ttctactatg agatccagaa tgcacctgag caagcctgcc780tcttagccaa acaagccttc gatgatgcca tagctgagct ggacacacta aacgaggatt840cctataagga ctccacgctg atcatgcagt tgctgcgaga caacctcacc ctctggacga900gcgaccagca ggatgaagaa gcaggagaag gcaactgaag atccttcagg tcccctggcc960cttccttcac ccaccacccc catcatcacc gattcttcct tgccacaatc actaaatatc 1020tagtgctaaa cctatctgta ttggcagcac agctactcag atctgcactc ctgtctcttg 1080ggaagcagtt tcagataaat catgggcatt gctggactga tggttgcttt gagcccacag 1140
gagctccctt tttgaattgt gtggagaagt gtgttctgat gaggcatttt actatgcctg 1200ttgatctatg ggaaatctag gcgaaagtaa tggggaagat tagaaagaat tagccaacca 1260ggctacagtt gatatttaaa agatccattt aaaacaagct gatagtgttt cgttaagcag 1320tacatcttgt gcatgcaaaa atgaattcac ccctcccacc tctttcttca attaatggaa 1380aactgttaag ggaagctgat acagagagac aacttgctcc tttccatcag ctttataata 1440aactgtttaa cgtgaggttt cagtagctcc ttggttttgc ctctttaaat tatgacgtgc 1500acaaaccttc ttttcaatgc aatgcatctg aaagttttga tacttgtaac tttttttttt 1560ttttggttgc aattgtttaa gaatcatgga tttatttttt gtaactcttt ggctattgtc 1620cttgtgtatc ctgacagcgc catgtgtgtc agcccatgtc aatcaagatg ggtgattatg 1680aaatgccaga cttctaaaat aaatgttttg gaattcaatg ggtaaataaa tgctgctttg 1740gggatattaa aaaaaaaaaa aaaaaaaaaa aaaaa 1775<210>9<211>1724<212>DNA<213>人<400>9ctttttggag acagattcgc agtggtcgct tcttctcctt ggatttgtta aggattccaa 60gtaactctta tttggagaga agacgatctg cacttcgcat tttggcattg acatttaatt120ttagggtcct ttatatagaa gggagagtag ctacatgaat gtgtaagatc ttggaggaag180acagcagaga gagagagaga gatcagagat cccagggtta aaagttggag aaatttcaca240gtacatcatc caaaagagga gtccatgatg gaggcagagg taaacttgga gaggacagga300agatgtcacc caagcgcata gctaaaagaa ggtccccccc agcagatgcc atccccaaaa360gcaagaaggt gaaggtctca cacaggtccc acagcacaga acccggcttg gtgctgacac420taggccaggg cgacgtgggc cagctggggc tgggtgagaa tgtgatggag aggaagaagc480cggccctggt atccattccg gaggatgttg tgcaggctga ggctgggggc atgcacaccg540tgtgtctaag caaaagtggc caggtctatt ccttcggctg caatgatgag ggtgccctgg600gaagggacac atcagtggag ggctcggaga tggtccctgg gaaagtggag ctgcaagaga660aggtggtaca ggtgtcagca ggagacagtc acacagcagc cctcaccgat gatggccgtg720tcttcctctg gggctccttc cgggacaata acggtgtgat tggactgttg gagcccatga780agaagagcat ggtgcctgtg caggtgcagc tggatgtgcc tgtggtaaag gtggcctcag840
gaaacgacca cttggtgatg ctgacagctg atggtgacct ctacaccttg ggctgcgggg900aacagggcca gctaggccgt gtgcctgagt tatttgccaa ccgtggtggc cggcaaggcc960tcgaacgact cctggtcccc aagtgtgtga tgctgaaatc caggggaagc cggggccacg 1020tgagattcca ggatgccttt tgtggtgcct atttcacctt tgccatctcc catgagggcc 1080acgtgtacgg cttcggcctc tccaactacc atcagcttgg aactccgggc acagaatctt 1140gcttcatacc ccagaaccta acatccttca agaattccac caagtcctgg gtgggcttct 1200ctggtggcca gcaccataca gtctgcatgg attcggaagg aaaagcatac agcctgggcc 1260gggctgagta tgggcggctg ggccttggag agggtgctga ggagaagagc atacccaccc 1320tcatctccag gctgcctgct gtctcctcgg tggcttgtgg ggcctctgtg gggtatgctg 1380tgaccaagga tggtcgtgtt ttcgcctggg gcatgggcac caactaccag ctgggcacag 1440ggcaggatga ggacgcctgg agccctgtgg agatgatggg caaacagctg gagaaccgtg 1500tggtcttatc tgtgtccagc gggggccagc atacagtctt attagtcaag gacaaagaac 1560agagctgatg aagcctctga gggcctggct tctgtcctgc acaacctccc tcacagaaca 1620gggaagcagt gacagctgca gatggcagcg ggcctctccc cagccctgag cactgtgtca 1680gttcctgcct tttctcatca gcagaacaga atccttttcc tctt1724<210>10<211>1622<212>DNA<213>人<400>10cgttggcgtt tacgtgtgga agagcggaag agttttgctt ttcgtgcgcg ccttcgaaaa 60ctgcctgccg ctgtctgagg agtccacccg aaacctcccc tcctccgccg gcagccccgc120gctgagctcg ccgacccaag ccagcgtggg cgaggtggga agtgcgcccg acccgcgcct180ggagctgcgc ccccgagtgc ccatggctac aagggtgctg agcatgagcg cccgcctggg240acccgtgccc cagccgccgg cgccgcagga cgagccggtg ttcgcgcagc tcaagccggt300gctgggcgcc gcgaatccgg cccgcgacgc ggcgctcttc cccggcgagg agctgaagca360cgcgcaccac cgcccgcagg cgcagcccgc gcccgcgcag gccccgcagc cggcccagcc420gcccgccacc ggcccgcggc tgcctccaga ggacctggtc cagacaagat gtgaaatgga480gaagtatctg acacctcagc ttcctccagt tcctataatt ccagagcata aaaagtatag540acgagacagt gcctcagtcg tagaccagtt cttcactgac actgaagggt taccttacag600
tatcaacatg aacgtcttcc tccctgacat cactcacctg agaactggcc tctacaaatc660ccagagaccg tgcgtaacac acatcaagac agaacctgtt gccattttca gccaccagag720tgaaacgact gcccctcctc cggccccgac ccaggccctc cctgagttca ccagtatatt780cagctcacac cagaccgcag ctccagaggt gaacaatatt ttcatcaaac aagaacttcc840tacaccagat cttcatcttt ctgtccctac ccagcagggc cacctgtacc agctactgaa900tacaccggat ctagatatgc ccagttctac aaatcagaca gcagcaatgg acactcttaa960tgtttctatg tcagctgcca tggcaggcct taacacacac acctctgctg ttccgcagac 1020tgcagtgaaa caattccagg gcatgccccc ttgcacatac acaatgccaa gtcagtttct 1080tccacaacag gccacttact ttcccccgtc accaccaagc tcagagcctg gaagtccaga 1140tagacaagca gagatgctcc agaatttaac cccacctcca tcctatgctg ctacaattgc 1200ttctaaactg gcaattcaca atccaaattt acccaccacc ctgccagtta actcacaaaa 1260catccaacct gtcagataca atagaaggag taaccccgat ttggagaaac gacgcatcca 1320ctactgcgat taccctggtt gcacaaaagt ttataccaag tcttctcatt taaaagctca 1380cctgaggact cacactggtg aaaagccata caagtgtacc tgggaaggct gcgactggag 1440gttcgcgcga tcggatgagc tgacccgcca ctaccggaag cacacaggcg ccaagccctt 1500ccagtgcggg gtgtgcaacc gcagcttctc gcgctctgac cacctggccc tgcatatgaa 1560gaggcaccag aactgagcac tgcccgtgtg acccgttcca ggtcccctgg gctccctcaa 1620at 1622<210>11<211>1221<212>DNA<213>人<400>11cgcaggctgg aaggaagacg aacctacgaa gcagagatct gaagacagca tgtacacagc 60cattccccag agtggctctc cattcccagg ctcagtgcag gatccaggcc tgcatgtgtg120gcgggtggag aagctgaagc cggtgcctgt ggcgcaagag aaccagggcg tcttcttctc180gggggactcc tacctagtgc tgcacaatgg cccagaagag gtttcccatc tgcacctgtg240gataggccag cagtcatccc gggatgagca gggggcctgt gccgtgctgg ctgtgcacct300caacacgctg ctgggagagc ggcctgtgca gcaccgcgag gtgcagggca atgagtctga360cctcttcatg agctacttcc cacggggcct caagtaccag gaaggtggtg tggagtcagc420
atttcacaag acctccacag gagccccagc tgccatcaag aaactctacc aggtgaaggg480gaagaagaac atccgtgcca ccgagcgggc actgaactgg gacagcttca acactgggga540ctgcttcatc ctggacctgg gccagaacat cttcgcctgg tgtggtggaa agtccaacat600cctggaacgc aacaaggcga gggacctggc cctggccatc cgggacagtg agcgacaggg660caaggcccag gtggagattg tcactgatgg ggaggagcct gctgagatga tccaggtcct720gggccccaag cctgctctga aggagggcaa ccctgaggaa gacctcacag ctgacaaggc780aaatgcccag gccgcagctc tgtataaggt ctctgatgcc actggacaga tgaacctgac840caaggtggct gactccagcc cctttgccct tgaactgctg atatctgatg actgctttgt900gctggacaac gggctctgtg gcaagatcta tatctggaag gggcgaaaag cgaatgagaa960ggagcggcag gcagccctgc aggtggccga gggcttcatc tcgcgcatgc agtacgcccc 1020gaacactcag gtggagattc tgcctcaggg ccgtgagagt cccatcttca agcaattttt 1080caaggactgg aaatgagggt gggcgtcttc ctgccccatg ctcccctgcc ccccaccacc 1140tgcctgcttg cttctctggc tgcctggtca gtgcagaggt gccccctgca gatgttcaat 1200aaaggagaca agtgctttcc c 1221<210>12<211>1460<212>DNA<213>人<400>12accccatctt catctggcct tgactctgcc cttgaggggc ctaggggtgc agccagcctg 60ctccgagctc ccctgcagat ggaggaggcc atcctggtcc cctgcgtgct ggggctcctg120ctgctgccca tcctggccat gttgatggca ctgtgtgtgc actgccacag actgccaggc180tcctacgaca gcacatcctc agatagtttg tatccaaggg gcatccagtt caaacggcct240cacacggttg ccccctggcc acctgcctac ccacctgtca cctcctaccc acccctgagc300cagccagacc tgctccccat cccaagatcc ccgcagcccc ttgggggctc ccaccggacg360ccatcttccc ggcgggattc tgatggtgcc aacagtgtgg cgagctacga gaacgagggt420gcgtctggga tccgaggtgc ccaggctggg tggggagtct ggggtccgtc ctggactagg480ctgacccctg tgtcgttacc cccagaacca gcctgtgagg atgcagatga ggatgaggac540gactatcaca acccaggcta cctggtggtg cttcctgaca gcaccccggc cactagcact600gctgccccat cagctcctgc actcagcacc cctggcatcc gagacagtgc cttctccatg660
gagtccattg atgattacgt gaacgttccg gagagcgggg agagcgcaga agcgtctctg720gatggcagcc gggagtatgt gaatgtgtcc caggaactgc atcctggagc ggctaagact780gagcctgccg ccctgagttc ccaggaggca gaggaagtgg aggaagaggg ggctccagat840tacgagaatc tgcaggagct gaactgaggg cctgtggagg ccgagtctgt cctggaacca900ggcttgcctg ggacggctga gctgggcagc tggaagtggc tctggggtcc tcacatggcg960tcctgccctt gctccagcct gacaacagcc tgagaaatcc ccccgtaact tattatcact 1020ttggggttcg gcctgtgtcc cccgaacgct ctgcaccttc tgacgcagcc tgagaatgac 1080ctgccctggc cccagcccta ctctgtgtaa tagaataaag gcctgcgtgt gtctgtgttg 1140agcgtgcgtc tgtgtgtgcc tgtgtgcgag tctgagtcag agatttggag atgtctctgt 1200gtgtttgtgt gtatctgtgg gtctccatcc tccatggggg ctcagccagg tgctgtgaca 1260ccccccttct gaatgaagcc ttctgacctg ggctggcact gctgggggtg aggacacatt 1320gccccatgag acagtcccag aacacggcag ctgctggctg tgacaatggt ttcaccatcc 1380ttagaccaag ggatgggacc tgatgacctg ggaggactct tttagttctt acctcttgtg 1440gttctcaata aaacagaacg 1460<210>13<211>1403<212>DNA<213>人<400>13gcttccgctt tggggtggtg gtgccacccg ccgtggccgg cgcccggccg gagctgctgg 60tggtggggtc gcggcccgag ctggggcgtt gggagccgcg cggtgccgtc cgcctgaggc120cggccggcac cgcggcgggc gacggggccc tggcgctgca ggagccgggc ctgtggctcg180gggaggtgga gctggcggcc gaggaggcgg cgcaggacgg ggcggagccg ggccgcgtgg240acacgttctg gtacaagttc ctgaagcggg agccgggagg agagctctcc tgggaaggca300atggacctca tcatgaccgt tgctgtactt acaatgaaaa caacttggtg gatggtgtgt360attgtctccc aataggacac tggattgagg ccactgggca caccaatgaa atgaagcaca420caacagactt ctattttaat attgcaggcc accaagccat gcattattca aggccgagta480cagatgctgc cccaggcggt gtgcctgctg catgcgctgc tggagaaggg acacatcgtg540tacgtgcact gcaacgctgg ggtgggccgc tccaccgcgg ctgtctgcgg ctggctccag600tatgtgatgg gctggaatct gaggaaggtg cagtatttcc tcatggccaa gaggccggct660
gtctacattg acgaagaggc cttggcccgg gcacaagaag attttttcca gaaatttggg720aaggttcgtt cttctgtgtg tagcctgtag ctggtcagcc tgcttctgcc ccctcctgat780ttccctaagg agcctgggat gatgttggtc aaatgaccta gaaacaagga ttctacctga840actgaaagga ctgtgtgacc tcccccaagc caaccacttt cacctgggat gactttcgat900tatgctttgt tttggggctg tatttttgaa atactctaca agaaagctgt ggctcaacac960atgagaagaa gcacgaagca gttaggctgt acatcagaca gaagggtaat gcgtgcagtt 1020cctgctgcct gcaggcagac gaggcctttg ctttacagca ctgtatgtgt tgcacgatgg 1080atccgtgaca gcactttcct gttgcactga aactcttggc catgtagagg aaaagatatg 1140gagttatgtg gatttcatca ctagtatgtg tgcgtgagct ggtcagttgc caaaggagga 1200aataaggtta gaagcctgaa ccgttacaaa agaagagctc actatggtca aaaagtgatg 1260gctttcagga cttgtttttt atcctgcctc acagttgtta aagtctgttc caaggcatca 1320ccttccttct ctacccaaca accctgtgta acaactaaag tagaattatc tccaaaaaaa 1380aaaaaaaaaa aaaaaaaaaa aaa 1403<210>14<211>3463<212>DNA<213>人<400>14atggctgagc cgactagtga tttcgagact cctatcgggt ggcatgcgtc tcccgagctg 60actcccacgt tagggcccct gagcgacact gccccgccgc gggacaggtg gatgttctgg120gcaatgctgc cgccaccgcc accaccactt acgtcctcgc ttcccgcagc cgggtcaaag180ccttcctctg agtcgcagcc ccccatggag gcccagtctc tccccggggc tccgcccccc240ttcgacgccc agattcttcc cggggcgcaa ccccccttcg acgcccagtc tccccttgat300tctcagcctc aacccagcgg ccagccttgg aatttccatg cttccacatc gtggtattgg360agacagtctt ctgataggtt tcctcggcat cagaagtcct tcaaccctgc agttaaaaat420tcttattatc cacgaaagta tgatgcaaaa ttcacagact tcagcttacc tcccagtaga480aaacagaaaa aaaagaaaag aaaggaacca gtttttcact ttttttgtga tacctgtgat540cgtggtttta aaaatcaaga aaagtatgac aaacacatgt ctgaacatac aaaatgccct600gaattagatt gctcttttac tgcacacgag aagattgtcc agttccattg gagaaatatg660catgctcctg gcatgaagaa gatcaagtta gacactccag aggaaattgc acggtggagg720
gaagaaagaa ggaaaaacta tccaactctg gccaatattg aaaggaagaa gaagttaaaa780cttgaaaagg agaagagagg agcagtattg acaacaacac aatatggcaa gatgaagggg840atgtccagac attcacaaat ggcaaagatc agaagtcctg gcaagaatca caaatggaaa900aacgacaatt ctagacagag agcagtcact ggatcaggca gtcacttgtg tgatttgaag960ctagaaggtc caccggaggc aaatgcagat cctcttggtg ttttgataaa cagtgattct 1020gagtctgata aggaggagaa accacaacat tctgtgatac ccaaggaagt gacaccagcc 1080ctatgctcac taatgagtag ctatggcagt ctttcagggt cagagagtga gccagaagaa 1140actcccatca agactgaagc agacgttttg gcagaaaacc aggttcttga tagcagtgct 1200cctaagagtc caagtcaaga tgttaaagca actgttagaa atttttcaga agccaagagt 1260gagaaccgaa agaaaagctt tgaaaaaaca aaccctaaga ggaaaaaaga ttatcacaac 1320tatcaaacgt tattcgaacc aagaacacac catccatatc tcttggaaat gcttctagct 1380ccggacattc gacatgaaag aaatgtgatt ttgcagtgtg ttcggtacat cattaaaaaa 1440gacttttttg gactggatac taattctgcg aaaagtaaag atgtataggc atctggtgtt 1500tcagcataca taactgaagc atgtgaaaca gtatcatcct cgttagtaga ggaaaaccaa 1560aacccttttt tccgtcaaaa ttggatttgt aattaaattg taagcctcgt aggatgtatg 1620ttggaatttt aagtctttcc tttggttcta tgcaaataaa aaaataactg attttttaag 1680actgtgtctg tattgttggg attgaatcta gtatttgctg ggagaatttt ttctttgtat 1740ttattttaat gtattgttct catgtaagaa tgactgatgt tgtgttagtt aagaattgaa 1800gataggttta gcagtaaaga agaaagcttt taaaaggatt gattcagcta agcaaagttg 1860ggcagagaaa tacagccatt ttgtttttaa tgcagaaaag gaagatgttc tgtagcaagg 1920gggaatattt taaaaataaa ccagatcaaa ttaatacaat cagaaggttt cgaaatgtaa 1980atattcctta tttaagacat gtttaaattc acctactagc acgacttaca tagctcaaat 2040attgaatgtt taaaatatta atacagatgg ggcctcttta tgtttagata aaattgaagt 2100acttaattga agctttttaa aaattgtaaa gtaaatgaaa gctattgaga tctttttgtc 2160tcctataata ccagggaatt tgagcttgtg ttctagtcat tgtactagct gtagctattg 2220gtctgtcctt ttgacataca gctaaaaggg actaaatttg taaaaaatta gtttgttata 2280gttgaagatt aacttttcct aacattgtga ttattgaagt tcatgaatct tgctgtcaag 2340gaagaaaggt aagaaagctg atagctcctc catgttggta aaatcctctc cagaatcttg 2400gaacacctgg catgtgaccc tagtgacgtc acagacctga gatgaagatt catgtttagc 2460
cagtgttttc cagccttgta cccaccatac agatctgttt attctgtttc accctactcc 2520tccagtgagc cccatatttt gggaaattat ctgccttata cattaactaa ttcaattcat 2580gtaacactgt tgagtgctta ctctttgtac ctctattgtg cctatattaa aggtatacaa 2640ataaataagg ccatgtctga cttcaaggaa ctcagtttaa ttttgatata ttcaaagatg 2700tgattcccaa ccaactcagg atgaagtaac tagtgttaca actgagttga tattctaaaa 2760tataacccag tttgtacttt tattactagt tagcatacac attttatggc ttatgggtta 2820ataaatgaat tcatggactc ctggactact ttcattgatg accatatctc cagggatgtt 2880gttgatcccc acactgcctt aaggtatatt atagaaacag ttttattttc catttttctt 2940gtttcctgat aataaatgta tttaggactg aaaatactcc tgagtactcc cctggctgta 3000tgtctgacag tctttagcta tggtgactat tgtttatttt taatgggtat ttcagattcc 3060aagtgtattt aaaatttcta aggagatata atatagcctg tatggtttct actttatgga 3120attatatggt caatatttgt aaatattcta tgagttttgg gtgggtagag gggtgctttg 3180cctgttttgg gtacaggttt ttttggattt agcttgttaa ttgttcaaac tttctgcctt 3240ctacattcct atcttattgt tcgtttaatc agtttctgaa atgtaagcat tacatgacta 3300ttggtgagtt gtgcctttta taactgaaat actttacttt ttctcatatc ctctataatt 3360gacttctatt ttccttaatc aaaccagctc tgggaaattt aatacattta tattaattga 3420gattattaaa acatttggac tattaaaaaa aaaaaaaaaa aaa 3463<210>15<211>5115<212>DNA<213>人<400>15gaattccggg agcgggcggg ctgcgaggcc gcggggcatg cgggaggcgg aggggtggga 60ccgggtggct gcgcccattc cacacccgcc gaaagcggac actgtcagct gaatcactcc120ccttttagga ggagggaggg ggaaaaggtg tctagctaat ttctgcttaa aaaagcacag180gagatcgcgg gtcagctttg cagtcgctgc cttctcgcgc ctgaccatgc acccctgcat240cttcctgctg ggcacaggcg agcgctttat ttctggagct gagggctaaa acttttttca300cttttcttct cctcaacatc tgaatcatgc catgtgccca gaggagctgg cttgcaaacc360tttccgtggt ggctcagctc cttaactttg gggcgctttg ctatgggaga cagcctcagc420caggcccggt tcgcttcccg gacaggaggc aagagcattt tatcaagggc ctgccagaat480
accacgtggt gggtccagtc cgagtagatg ccagtgggca ttttttgtca tatggcttgc540actatcccat cacgagcagc aggaggaaga gagatttgga tggctcagag gactgggtgt600actacagaat ttctcacgag gagaaggacc tgttttttaa cttgacggtc aatcaaggat660ttctttccaa tagctacatc atggagaaga gatatgggaa cctctcccat gttaagatga720tggcttcctc tgcccccctc tgccatctca gtggcacggt tctacagcag ggcaccagag780ttgggacggc agccctcagt gcctgccatg gactgactgg atttttccaa ctaccacatg840gagacttttt cattgaaccc gtgaagaagc atccactggt tgagggaggg taccacccgc900acatcgttta caggaggcag aaagttccag aaaccaagga gccaacctgt ggattaaagg960acagtgttaa catctcccag aagcaagagc tatggcggga gaagtgggag aggcacaact 1020tgccaagcag aagcctctct cggcgttcca tcagcaagga gagatgggtg gagacactgg 1080tggtggccga cacaaagatg attgaatacc atgggagtga gaatgtggag tcctacatcc 1140tcaccatcat gaacatggtc actgggttgt tccataaccc aagcattggc aatgcaattc 1200acattgttgt ggttcggctc attctactcg aagaagaaga gcaaggactg aaaatagttc 1260accatgcaga aaagacactg tctagcttct gcaagtggca gaagagtatc aatcccaaga 1320gtgacctcaa tcctgttcat cacgacgtgg ctgtccttct caccagaaag gacatctgtg 1380ctggtttcaa tcgcccctgc gagaccctgg gcctgtctca cctttcagga atgtgtcagc 1440ctcaccgcag ttgtaacatc aatgaagatt cgggactccc tctggctttc acaattgccc 1500atgagctagg acacagcttc ggcatccagc atgatgggaa agaaaatgac tgtgagcctg 1560tgggcagaca tccgtacatc atgtcccgcc agctccagta cgatcccact ccgctgacat 1620ggtccaagtg cagcgaggag tacatcaccc gcttcttgga ccgaggctgg gggttctgtc 1680ttgatgacat acctaaaaag aaaggcttga agtccaaggt cattgccccc ggagtgatct 1740atgatgttca ccaccagtgc cagctacaat atggacccaa tgctaccttc tgccaggaag 1800tagaaaacgt ctgccagaca ctgtggtgct ccgtgaaggg cttttgtcgc tctaagctgg 1860acgctgctgc agatggaact caatgtggtg agaagaagtg gtgtatggca ggcaagtgca 1920tcacagtggg gaagaaacca gagagcattc ctggaggctg gggccgctgg tcaccctggt 1980cccactgttc caggacctgt ggggctggag tccagagcgc agagaggctc tgcaacaacc 2040ccgagccaaa gtttggaggg aaatattgca ctggagaaag aaaacgctat cgcttgtgca 2100acgtccaccc ctgtcgctca gaggcaccaa catttcggca gatgcagtgc agtgaatttg 2160
acactgttcc ctacaagaat gaactctacc actggtttcc catttttaac ccagcacatc 2220cttgtgagct ctactgccga cccatagatg gccagttttc tgagaaaatg ctggatgctg 2280tcattgatgg taccccttgc tttgaaggcg gcaacagcag aaatgtctgt attaatggca 2340tatgtaagat ggttggctgt gactatgaga tcgattccaa tgccaccgag gatcgctgcg 2400gtgtgtgcct gggagatggc tcttcctgcc agactgtgag aaagatgttt aagcagaagg 2460aaggatctgg ttatgttgac attgggctca ttccaaaagg agcaagggac ataagagtga 2520tggaaattga gggagctgga aacttcctgg ccatcaggag tgaagatcct gaaaaatatt 2580acctgaatgg agggtttatt atccagtgga acgggaacta taagctggca gggactgtct 2640ttcagtatga caggaaagga gacctggaaa agctgatggc cacaggtccc accaatgagt 2700ctgtgtggat ccagcttcta ttccaggtga ctaaccctgg catcaagtat gagtacacaa 2760tccagaaaga tggccttgac aatgatgttg agcagatgta cttctggcag tacggccact 2820ggacagagtg cagtgtgacc tgcgggacag gtatccgccg ccaaactgcc cattgcataa 2880agaagggccg cgggatggtg aaagctacat tctgtgaccc agaaacacag cccaatggga 2940gacagaagaa gtgccatgaa aaggcttgtc cacccaggtg gtgggcaggg gagtgggaag 3000catgctcggc gacatgcggg ccccacgggg agaagaagcg aaccgtgctg tgcatccaga 3060ccatggtctc tgacgagcag gctctcccgc ccacagactg ccagcacctg ctgaagccca 3120agaccctcct ttcctgcaac agagacatcc tgtgcccctc ggactggaca gtgggcaact 3180ggagtgagtg ttctgtttcc tgtggtggtg gagtgcggat tcgcagtgtc acatgtgcca 3240agaaccatga tgaaccttgc gatgtgacaa ggaaacccaa cagccgagct ctgtgtggcc 3300tccagcaatg cccttctagc cggagagttc tgaaaccaaa caaaggcact atttccaatg 3360gaaaaaaccc accaacacta aagcccgtcc ctccacctac atccaggccc agaatgctga 3420ccacacccac agggcctgag tctatgagca caagcactcc agcaatcagc agccctagtc 3480ctaccacagc ctccaaagaa ggagacctgg gtgggaaaca gtggcaagat agctcaaccc 3540aacctgagct gagctctcgc tatctcattt ccactggaag cacttcccag cccatcctca 3600cttcccaatc cttgagcatt cagccaagtg aggaaaatgt ttccagttca gatactggtc 3660ctacctcgga gggaggcctt gtagctacaa caacaagtgg ttctggcttg tcatcttccc 3720gcaaccctat cacttggcct gtgactccat tttacaatac cttgaccaaa ggtccagaaa 3780tggagattca cagtggctca ggggaagaaa gagaacagcc tgaggacaaa gatgaaagca 3840atcctgtaat atggaccaag atcagagtac ctggaaatga cgctccagtg gaaagtacag 3900
aaatgccact tgcacctcca ctaacaccag atctcagcag ggagtcctgg tggccaccct 3960tcagcacagt aatggaagga ctgctcccca gccaaaggcc cactacttcc gaaactggga 4020cacccagagt tgaggggatg gttactgaaa agccagccaa cactctgctc cctctgggag 4080gagaccacca gccagaaccc tcaggaaaga cggcaaaccg taaccacctg aaacttccaa 4140acaacatgaa ccaaacaaaa agttctgaac cagtcctgac tgaggaggat gcaacaagtc 4200tgattactga gggctttttg ctaaatgcct ccaattacaa gcagctcaca aacggccacg 4260gctctgcaca ctggatcgtc ggaaactgga gcgagtgctc caccacatgt ggcctggggg 4320cctactggaa aagggtggag tgcaccaccc agatggattc tgactgtgcg gccatccaga 4380gacctgaccc tgcaaaaaga tgccacctcc gtccctgtgc tggctggaaa gtgggaaact 4440ggagcaagtg ctccagaaac tgcagtgggg gcttcaagat acgcgagatt cagtgcgtgg 4500acagccggga ccaccggaac ctgaggccat ttcactgcca gttcctggcc ggcattcctc 4560ccccattgag catgagctgt aacccggagc cctgtgaggc gtggcaggtg gagccttgga 4620gccagtgctc caggtcctgt ggaggtggag ttcaggagag aggagtgttc tgtccaggag 4680gcctctgtga ttggacaaaa agacccacat ccaccatgtc ttgcaatgag cacctgtgct 4740gtcactgggc cactgggaac tgggacctgt gttccacttc ctgtggaggt ggctttcaga 4800agaggattgt ccaatgtgtg ccctcagagg gcaataaaac tgaagaccaa gaccaatgtc 4860tatgtgatca caaacccaga cctccagaat tcaaaaaatg caaccagcag gcctgcaaga 4920aaagtgccga tttactttgc actaaggacaaactgtcagc cagtttctgc cagacactga4980aagccatgaa gaaatgttct gtgcccaccg tgagggctga gtgctgcttc tcgtgtcccc 5040agacacacat cacacacacc caaaggcaaa gaaggcaacg gttgctccaa aagtcaaaag 5100aactctaagc ccaaa5115<210>16<211>528<212>DNA<213>人<400>16cgccagggag ctgtgaggca gtgctgtgtg gttcctgccg tccggactct ttttcctcta 60ctgagattca tctgtgtgaa atatgagttg gcgaggaaga tcgacctatt attggcctag120accaaggcgc tatgtacagc ctcctgaaat gattgggcct atgcggcccg agcagttcag180tgatgaagtg gaaccagcaa cacctgaaga aggggaacca gcaactcaac gtcaggatcc240
tgcagctgct caggagggag aggatgaggg agcatctgca ggtcaagggc cgaagcctga300agctgatagc caggaacagg gtcacccaca gactgggtgt gagtgtgaag atggtcctga360tgggcaggag atggacccgc caaatccaga ggaggtgaaa acgcctgaag aaggtgaaaa420gcaatcacag tgttaaaaga aggcacgttg aaatgatgca ggctgctcct atgttggaaa480tttgttcatt aaaattctcc caataaagct ttacagcctt ctgcaaaa 528<210>17<211>2247<212>DNA<213>人<400>17tttcttgagc taggaaaggt ggttggctta cggcacagta gagagcttcc agggctggct 60ggcgtgggat acccgtacca cagaaatgca gggaccattg cttcttccag gcctctgctt120tctgctgagc ctctttggag ctgtgactca gaaaaccaaa acttcctgtg ctaagtgccc180cccaaatgct tcctgtgtca ataacactca ctgcacctgc aaccatggat atacttctgg240atctgggcag aaactattca cattcccctt ggagacatgt aacgacatta atgaatgtac300accaccctat agtgtatatt gtggatttaa cgctgtgtgt tacaatgtcg aaggaagttt360ctactgtcaa tgtgtcccag gatatagact gcattctggg aatgaacaat tcagtaattc420caatgagaac acctgtcagg acaccacctc ctcaaagaca accgagggca ggaaagagct480gcaaaagatt gtggacaaat ttgagtcact tctcaccaat cagactttat ggagaacaga540agggagacaa gaaatctcat ccacagctac cactattctc cgggatgtgg aatcgaaagt600tctagaaact gccttgaaag atccagaaca aaaagtcctg aaaatccaaa acgatagtgt660agctattgaa actcaagcga ttacagacaa ttgctctgaa gaaagaaaga cattcaactt720gaacgtccaa atgaactcaa tggacatccg ttgcagtgac atcatccagg gagacacaca780aggtcccagt gccattgcct ttatctcata ttcttctctt ggaaacatca taaatgcaac840tttttttgaa gagatggata agaaagatca agtgtatctg aactctcagg ttgtgagtgc900tgctattgga cccaaaagga acgtgtctct ctccaagtct gtgacgctga ctttccagca960cgtgaagatg acccccagta ccaaaaaggt cttctgtgtc tactggaaga gcacagggca 1020gggcagccag tggtccaggg atggctgctt cctgatacac gtgaacaaga gtcacaccat 1080gtgtaattgc agtcacctgt ccagcttcgc tgtcctgatg gccctgacca gccaggagga 1140ggatcccgtg ctgactgtca tcacctacgt ggggctgagc gtctctctgc tgtgcctcct 1200
cctggcggcc ctcacttttc tcctgtgtaa agccatccag aacaccagca cctcactgca 1260tctgcagctc tcgctctgcc tcttcctggc ccacctcctc ttcctcgtgg ggattgatcg 1320aactgaaccc aaggtgctgt gctccatcat cgccggtgct ttgcactatc tctacctggc 1380cgccttcacc tggatgctgc tggagggtgt gcacctcttc ctcactgcac ggaacctgac 1440agtggtcaac tactcaagca tcaatagact catgaagtgg atcatgttcc cagtcggcta 1500tggcgttccc gctgtgactg tggccatttc tgcagcctcc tggcctcacc tttatggaac 1560tgctgatcga tgctggctcc acctggacca gggattcatg tggagtttcc ttggcccagt 1620ctgtgccatt ttctctgcga atttagtatt gtttatcttg gtcttttgga ttttgaaaag 1680aaaactttcc tccctcaata gtgaagtgtc aaccatccag aacacaagga tgctggcttt 1740caaagcaaca gctcagctct tcatcctggg ctgcacatgg tgtctgggct tgctacaggt 1800gggtccagct gcccaggtca tggcctacct cttcaccatc atcaacagcc tccaaggctt 1860cttcatcttc ttggtctact gcctcctcag ccagcaggtc cagaaacaat atcaaaagtg 1920gtttagagag atcgtaaaat caaaatctga gtctgagaca tacacacttt ccagcaagat 1980gggtcctgac tcaaaaccca gtgaggggga tgtttttcca ggacaagtga agagaaaata 2040ttaaaactag aatattcaac tccatatgga aaatcatatc catggatctc tttggcatta 2100tgaagaatga agctaaggaa aagggaattc attaaacata tcatccttgg agaggaagta 2160atcaaccttt acttcccaag ctgtttgttc tccacaatag gctctcaaca aatgtgtggt 2220aaattgcatt tctcttcaaa aaaaaaa 2247<210>18<211>1325<212>DNA<213>人<400>18accaatcctc acctctcacc tctgtgtccg ccctgctggg aaatattcca ggctttggcc 60aaggccagtg cagccccagg ttcccgagcg gcaggttggg tgcggaccat ggcctctcac120aagctgctgg tgaccccccc caaggccctg ctcaagcccc tctccatccc caaccagctc180ctgctggggc ctggtccttc caacctgcct cctcgcatca tggcagccgg ggggctgcag240atgatcgggt ccatgagcaa ggatatgtac cagatcatgg acgagatcaa ggaaggcatc300cagtacgtgt tccagaccag gaacccactc acactggtca tctctggctc gggacactgt360gccctggagg ccgccctggt caatgtgctg gagcctgggg actccttcct ggttggggcc420
aatggcattt gggggcagcg agccgtggac atcggggagc gcataggagc ccgagtgcac480ccgatgacca aggaccctgg aggccactac acactgcagg aggtggagga gggcctggcc540cagcacaagc cagtgctgct gttcttaacc cacggggagt cgtccaccgg cgtgctgcag600ccccttgatg gcttcgggga actctgccac aggtacaagt gcctgctcct ggtggattcg660gtggcattcc tgggcgggac ccccctttac atggaccggc aaggcatcga catcctgtac720tcgggctccc agaaggccct gaacgcccct ccagggacct cgctcatctc cttcagtgac780aaggccaaaa agaagatgta ctcccgcaag acgaagccct tctccttcta cctggacatc840aagtggctgg ccaacttctg gggctgtgac gaccagccca ggatgtacca tcacacaatc900cccgtcatca gcctgtacag cctgagagag agcctggccc tcattgcgga acagggcctg960gagaacagct ggcgccagca ccgcgaggcc gcggcgtatc tgcatgggcg cctgcaggca 1020ctggggctgc agctcttcgt gaaggacccg gcgctccggc ttcccacagt caccactgtg 1080gctgtacccg ctggctatga ctggagagac atcgtcagct acgtcataga ccacttcgac 1140attgagatca tgggtggcct tgggccctcc acggggaagg tgctgcggat cggcctgctg 1200ggctgcaatg ccacccgcga gaatgtggac cgcgtgacgg aggccctgag ggcggccctg 1260cagcactgcc ccaagaagaa gctgtgacct gcccactggc acacagctgg cactggcaca 1320cacct 1325<210>19<211>2263<212>DNA<213>人<400>19agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag 60agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct120ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata180ttgcccacag ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc240ctggggtaga ggtgaccctg acgatgaaag cggccagtgg tagcacaggc gaccagaagg300ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg360cggtggaaat ctccctgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag420ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg480tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc540
ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg600acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga660gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca720agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg780aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc840tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc900gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca960gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt 1020gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa 1080tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa 1140ggaacagagg cctgaaggag tttcccatca aacgagtgat gggtccagat tttggctatg 1200taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag 1260tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg 1320acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca 1380gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg 1440tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg 1500ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg 1560ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa 1620acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc 1680tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca 1740agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc 1800tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc 1860tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg 1920acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa 1980agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc 2040tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa 2100tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg 2160atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct 2220
gctctaagaa gctgcaataa agttttttta agtcactttg tac 2263<210>20<211>2772<212>DNA<213>人<400>20cagtcggcac cggcgaggcc gtgctggaac ccgggcctca gccgcagccg cagcggggcc 60gacatgacga cagctcccca ggagcccccc gcccggcccc tccaggcggg cagtggagct120ggcccggcgc ctgggcgcgc catgcgcagc accacgctcc tggccctgct ggcgctggtc180ttgctttact tggtgtctgg tgccctggtg ttccgggccc tggagcagcc ccacgagcag240caggcccaga gggagctggg ggaggtccga gagaagttcc tgagggccca tccgtgtgtg300agcgaccagg agctgggcct cctcatcaag gaggtggctg atgccctggg agggggtgcg360gacccagaaa ccaactcgac cagcaacagc agccactcag cctgggacct gggcagcgcc420ttctttttct cagggaccat catcaccacc atcggctatg gcaatgtggc cctgcgcaca480gatgccgggc gcctcttctg catcttttat gcgctggtgg ggattccgct gtttgggatc540ctactggcag gggtcgggga ccggctgggc tcctccctgc gccatggcat cggtcacatt600gaagccatct tcttgaagtg gcacgtgcca ccggagctag taagagtgct gtcggcgatg660cttttcctgc tgatcggctg cctgctcttt gtcctcacgc ccacgttcgt gttctgctat720atggaggact ggagcaagct ggaggccatc tactttgtca tagtgacgct taccaccgtg780ggctttggcg actatgtggc cggcgcggac cccaggcagg actccccggc ctatcagccg840ctggtgtggt tctggatcct gctcggcctg gcttacttcg cctcagtgct caccaccatc900gggaactggc tgcgagtagt gtcccgccgc actcgggcag agatgggcgg cctcacggct960caggctgcca gctggactgg cacagtgaca gcgcgcgtga cccagcgagc cgggcccgcc 1020gccccgccgc cggagaagga gcagccactg ctgcctccac cgccctgtcc agcgcagccg 1080ctgggcaggc cccgatcccc ttcgcccccc gagaaggctc agccgccttc cccgcccacg 1140gcctcggccc tggattatcc cagcgagaac ctggccttca tcgacgagtc ctcggatacg 1200cagagcgagc gcggctgccc gctgccccgc gcgccgagag gtcgccgccg cccaaatccc 1260cccaggaagc ccgtgcggcc ccgcggcccc gggcgtcccc gagacaaagg cgtgccggtg 1320taggggcagg atccctggcc gggcctctca agggcttcgt ttctgctctc cccggcatgc 1380ctggcttgtt tgaccaaaga gccctctttc cacgagactg aagtctgggg aggaggctac 1440
agttgcctct ccgcctcctc cctggccccg gcccttccct cacttccatc catctctaga 1500cccccccaag gctttctgtg tcgctgcccc gggcgggtgt atccctcaca gcacctcacg 1560actgtgcctc aaagcctgca tcaataaatg aaaacggtct gcaccgctgc gggcgtgacg 1620ctcccggacg cgagtgggtg tggaattgct ttcctcgggc caccgtgggg gcacctctgg 1680cctcccgtga cccccaggcc gagggtcccc gggcacccag gtcggtcaag tctcggccct 1740ctcaggcccg cgtctctgcc tggaggagac tgtgtagggt ccggcgtggg gatcagccgg 1800gatgggctgc gcgtctccag cctctgcaca cacattggcg ggtggggtgc agggagggag 1860aggcagggga gagagaatgg catctcgcgt ggagggctgt cgtttgaact ctcccagcgc 1920gagagaccct gccccgcccc cttcctggag cgttgactcc cttctcgtct cgaggcctgt 1980ggcgtctggg tccgttgggg cagaaccatg gaggaaaagc cttcgaaagt gtcgctcaag 2040tcttccgacc gccaaggctc ggacgaggag agcgtgcata gcgacactcg ggacctgtgg 2100accacgacca cgctgtccca ggcacagctg aacatgccgc tgtccgaggt ctgcgagggc 2160ttcgacgagg agggccgcaa cattagcaag acccgcgggt ggcacagccc ggggcggggc 2220tcgttggacg aggggtacaa ggccagccac aagccggagg aactggacga gcacgcgctg 2280gtggagctgg agttgcaccg cggcagctcc atggaaatca atctggggga gaaggacact 2340gcatcccaga tcgaggccga aaagtcttcc tcaatgtcat cactcaatat tgcgaagcac 2400atgccccatc gagcctactg ggcagagcag cagagcaggc tgccactgcc cctgatggaa 2460ctcatggaga atgaagctct ggaaatcctc accaaagccc tccggagcta ccagttaggg 2520atcggcaggg accacttcct gactaaggag ctgcagcgat acatcgaagg gctcaagaag 2580cgccggagca agaggctgta cgtgaattaa aaacgccacc ttgggctcga gcagcgaccc 2640gaaccagccc cgtgccagcc cggtccccag acccaagcct gaccccatcc gagtggaatt 2700tgagtcctaa agaaataaaa gagtcgatgc atgaaaaaaa aaaaaaaaaa aaaaaaaaaa 2760aaaaaaaaaa aa 2772<210>21<211>7909<212>DNA<213>人<400>21ttcaagtatg gcagacaaag gatgttctgc gtggggaaat gtggtgacac ccatttcaca 60aggacagctc acatagattg agtgctcagg aaggaccagc accataccca gtgcctgatg120
tgtatcatct caattagtcc ttgcctcaga tgcaaaagga aaccatcgcc atcatcatca180ccaccatcat catcttcctc ctgtgcagat ggaaaggctg aggcatagag aggtgacgga240gtctgcccag gactgcaagc ctgctggtgg cagagccagg ttccaatgga atgaaggctg300tcatcctcag atggcagggt aggcaggtgg ctagagctca cttgggagaa ggggaaagga360cactgacttt ggctagggat ggagcagagc ttgggctggc tttccatgca cgggcagggg420gcgtggctca tggctacgct ccagccccgg gtgtggacat tgaatcttcc aggtctaccc480taggctatgg gtctggacag cactgtgatg gaaagaagac actctatgtc ctgcattctg540tgaccaatga tgtgactgtg ggaatggcgc tggcatctgg ctgccactct gggacgggtg600gccagctgcc atcaggcccc acccaggatg ggaccaccat gcgacttctt ccctcgctcc660tcctggtcat gtccagagcc ccaggaggac cagcaaagcc tctcgagccg atggcagctc720acgttctgcc ttgtcagcta ctcctctcct gggcaatatt ggctgcttgc tgtggctctc780cccggggtat gtgactgcct ctgtgctggg cacctggcct gggctttcct tctgggcctg840ggcagctggg ctcagcttgg acccaggcag cagccacaga ggggcccatg gaggtgacag900agttgcttct atgatggtga acgggcagct gtgacacgga ggaggcgacc actcctcagt960ttccaagtgc tgcggtcagg gccggggcca gcaaagtccc tcccatattc aaagagcggg 1020tttgggtttg tcccaggagg acatagtcag gagcccatgc tgggacatgc ctcctccaaa 1080gttcagcctg gatccccagc ctctgccaac ggccccgctc cttagctaac ccagcttgct 1140cctgggttcc acggcggagt cagatgtttc tgggcagttt cacctttgtg ccttaaatgc 1200atgttgagga ctttaaggaa ttgtggagaa atagggctgt ggcaaaggca agtgacaact 1260gggaacaatg atcccgcaga ggctgctgag gcctgggccc caggggcgtg ggttcatcct 1320tctgcctggg ctttggtggg aggggcagac tctgtggtct gagacacaaa aaaacccaaa 1380acatatgtgt gtacagacac acagcagagc cacacacaca cttgtgccca tgcacacact 1440cacaggaggc ccgtggactc cgcacaggga agaaactcct ccggtcgaca gtggacggcg 1500ctgcagcagg gactcacccc caagccctgc ctgcctccca ttgcccacct ggccctggct 1560tgatgggctt atctcatgct gtggccgggg acctcttgct tcctgcaacc ccttgctgga 1620ctggggcctg ggcctctcct gggctgtgcc tagggtttgt aacccagggc ctgtgccggc 1680gtgcacagag catctctccc tgggaggctc agggctgcct cctcgagctc tgtgggcctg 1740cactggccgg tgagcttgtg gtgtgggttt tcaggctgta tccttctacc tcctgagccc 1800aggggtccca ggcgccctgc agctgtctcc tcggccatcc tgtggggccc cgaggccttg 1860
ccctcacttc agtgcctggg tgctcaggct ttgcccaggt gccaggagaa ggtgtgagca 1920tgagcctatt ggacacacct ggcgacgtat accaggtgtc ccacccctgc caccatgggg 1980cctcccgata cggcaaccac cacggacctg tggggaccaa tgaggaaaga gagaggcagg 2040tctgggccag gctcacaggg actccggcat agcagaccct gccccagcag gcccccttgt 2100ccttcctggg tcctggtcct tcatgaggaa ctagcccatc cctggtgggg ctcccacccc 2160gcttctcagt gggctctatg cttgcctcgt cggagtcacc cctcaggcag tcctgggatc 2220ctctccttta gacccactgt gccttcccgg cctcccgggc ttctgctggg ggcagaagaa 2280atgcctcccc aggtctgtct ctggaggctc tgagggagat gggcttgggg gctgtaggag 2340gaggcaggga ttccagggtg tcaggaaggc aggggtgcca ggtcccacct agtgaagtaa 2400taaaccgtgg gtggtgatag tgacccagtg ccctcactgc ccagccccgc ctgtcctcag 2460ccagcactgc agggatccca ggcccagact ctggaggcct tcactgatcc cagccacccc 2520agaaaagctg cagcctgcag gcaccagccg ggccatatgc ccagtgccag ctagggccca 2580ccgcccatcc tgcacacggg gccgctgggc aggtgcccct cacaccccca ggatgtcagt 2640gctcacctcg agcaaagcgc cccagctcgg ccttgggagg tggtcatgtc cagggggatg 2700atggagagct gtccaaccaa gagagcggga gggagggaag gagggaggga gagagataga 2760gagagagaga gagagagagg aagtgtgggc cctaaggctg ccttagtgga ggtgcgcgtg 2820gcctgcacct caccaagcct agccactctc gcggctctga gtggctcaca ggcttgtgag 2880ggccccgtcg ctgcctgctg ggtccccacc agggctccct ctaggaatgc gccatggctg 2940ctatgacaat ttgcacagcc cagtggctta aacaccattt ataccacagg tccagatgaa 3000tcctgcaggg ccaaggtctg ggggtgctgg aggccatgct ccctccaggc ttgcggggag 3060aacttccctg cctcctccag tctctccatc cctgagctct cggctcctcc tccgtcttca 3120gggccagggc gtagcgtctg ctctctcggc ctctgcctcc gcttcccacc tcacctggct 3180tctgtctatg tcagtctccc tctgccaacc tcctagaagg acacttgtga ttacattagg 3240gctcacccct ttaatccagg ggagcctctc cacttcatga ttttcagcta acttgcttct 3300gcacagaccc cctttcccta taagggcaca cattcactgg tcccggggct aaggaccttg 3360ctccaagtcc ctccacccat gatgctgtgc cttccagaaa cctgtcctct gcagctcggt 3420cttgacccca agcctgctgg tgacctgaac ttcacagggt tatccccttg gactgtgtgc 3480agcacgatgc aatttctggg cctgaatgtc atgctccctg gggcaggacc ttgagcctgc 3540
agcacacact aggccacctg cagtctcaca ggccatgccc tgggtagaca gggaggtgct 3600caaccccagc tcgggtcctc tagtctgcct ggctaccatg cttctcactc tcctgcatct 3660gcagaccctg cgttgccatg tgaggcaggg gtggggtggg gctgagggcg tggctttggt 3720ccctggctgt ccggatgaag taccagagtg acgccacagc ccatcccggt gacatgctca 3780cccccaaccc ccgtgtccgg gaccccggtc ttgtgtggtc cctgatgtgg agtcctcagt 3840ccttaagata catccagaaa gtcctggcca tgaattggag gtgcagagtc ctgcagagcc 3900tctgggctgg gctggtgccc ccaggagatg gagggcctgg tggatgccct cctccctcag 3960agctggggca gctgcctccc aggggtggga ctctgggctc agagagaggc ccttgagctg 4020cagctcaggg ggatgcgagg cttcgtggac tgtgtcctgg tccatgtggt gcacgtgtct 4080ccacctccaa ggagaggctc ctcagtgtgc acctccccca catccgtcct ctctgccggc 4140cccgggcgtc tgagcagtca ttccatgcca gcacctctgc agcctgctgg gcctcaggtt 4200ctctgtgagg gacctccccg gccttcggcg gaggtggagt aagctccgtc aaggcaggtg 4260gcttcgtccc ttcctgtgag tgacaccagt gatgaaatgg acccctccac acaggcatcc 4320tcagggcaca gggccctggg ggcaccttcc tcctttcgta tttgttgaga aaaaaagtgg 4380cattgcgctc acaccaggat gctggagcag agctgacatg ctcgggaaag ggcagaggtc 4440actgggggtg ggaaggtcat ccagtccaga ctcagcacct cgtgggctgg taaactgagg 4500ctcaaagtgc tggtgccagg cctgaggcct cgcggtgacc cctctctctg gttcccagca 4560cctgcctgag acctgcccca ggcacccata acctggaatt ccctgtttcc ttgtccaggg 4620cctgaggaaa tggctcccca ggtctgtctc tggatgctct gaggcagatg ggcttggggg 4680ctctaggagg aggcagggac tccagggtgt caggaaggca ggggtgccgg gtcccaccca 4740gtggagtaac aaactgtggg tggcgtttgg gcctccccgc cttccccact gggtgtgctg 4800gtgctggcgc tgctgggtca gggctgcccg tgaccccaga caccactgtc catcctgtga 4860ggctcccgtc tgggcatgtc ctgggtggat tcctcctttc tgttaagtag ctacatgagg 4920caggggctcc tggatccaaa gcaaatgaca ggaattccag agccaggtgc atccactcag 4980ggcagccagt gttggtggag ctgcctctag cacatggagg agagtgaaag tcagcctgcc 5040cctctcacga gaaaagaacc tggggatacc tctcagcctc cagcgttgca agtgcaaggc 5100cagtggagtt aatctgcaac gtgcacgagg gcgtgtgtca gtggctgtgt gcaggagtgt 5160gagtgagcaa gagcaagagc gcatggctcc tgctgtacct caaggtgtgg gctcctggtg 5220gctgctcagt gttcccaggg gtgagaggcc tcatgtatcc taggctgcct gagatttctg 5280
tgtgctgatc gcatcctcag tttcttgtcc accgcttcac tggcaagagt cccaggctcc 5340aaggacaccc tccctgcaca tgattgggtg ttaatggtgg cctgggttgt gtcttcccct 5400ggggatgagg gttgggtgtc catggtgccc tgggctgtgt cctcccctag ggatgagggt 5460cgggcctcca cgatgccctg ggctgtgtgc tcttatggga atgagggttg ggtgtccaag 5520atgccctggg ctgtgtcctt ccctggggat gagggttgga tgtccaagat gccctgggct 5580gtgtactccc ctaggaatga gggctgggtg tccaagatac cctgggctgt gtcctcccct 5640ggggatgagg gttgggtgtc catggtgccc tgggctgtgt cctcccctgg ggatgacggt 5700tgggtgtcca tggtgccctg ggctgtgttt ccttggggat gagggttggg tgctatggca 5760tcctgggcag gtgcttcctt tctgcacaag ggttgggtga ccatgatgtc ctggcaatgg 5820cttccctggg ttgcctcttt tctgccatgt gggaagagca ggggaggttt agttggtctc 5880agcacatcat tctctcagga taagtagaag agtgtctgag ctgtgaggcc agtgctccag 5940ctttggaatt gtcttcccca ccctcacctc catcccatca aagcccgaca tgtcgtgtgg 6000cagcagcgag gtgggtgttg gctgttctct tgggctgggg gttagtcgtg gacggggaaa 6060ggagagatgc tggtcaaagg gcatgaagtt tctgctgatg ggaggagtca gttcttttga 6120tctgttgcac agcatggtga ctatagttaa caataatgac tatttcaaaa ttgctaaaag 6180atgagatttt aaatgttctc accacaaaat gataagtgtg tgaggtgatg gatatgccac 6240ttaccttgtt ttaatcatcc cacaatatag acaggcattg tcactttgca ttgtacccca 6300ggaatcttca catttgcttt tttgtcaatt aaaaatagag acacaaaagg agagagggga 6360gagcaataga ctcttcacgg aaccgtgggc ttctgcctcc gggtaaaata aactgcaaaa 6420aggattccca ggaaaccgtt ccctctttca gcccttggtt acaggaagcc ggatttggga 6480aatctgcctg gatgacattc acatgaacgg gcacatacag gaaaacacgg taatgtaatt 6540agaatagtca gagaaaagta gccagaaatg acattcacat gaacgggcac atacaggaga 6600aaacacggta acgtaattag aatagtcaga gaaaagtagc cagaaatgac attcacatga 6660acgggcacat ataggagaaa ccatggtaac gtaattagaa tagtcagaga aaagtagcca 6720gaaatgacat tcacatgaac gggcacatac aggaaaacac ggtaatgtaa ttagaatagt 6780cagagaaaag tagccagaaa tgacattcac atgaacgggc acatacagga gaaaacacgg 6840taacgtaatt agaatagtca gagaaaagta gccagaaatg acattcacat gaacgggcac 6900atacaggaga aaacacggta acgtaattag aatagtcaga gaaaagtagc cagaagaatt 6960
tgcaacgtgc ccttgtaaca ccaaatttga tcagtttttt aaaaaatgat cgttatgtag 7020gtgattgaga agtaaatgta ttctttttta aggtaaaaat ttggaccctt atcatgcata 7080cccccctctg tgctcttcaa atcaacatca ttattaatat ctgtacattt ttgctcatct 7140gagccagcac aggctgaggc tgtcagaatg gacacctttt ggttgttggg tttctgtcag 7200tttctggggt gaagctgcgt gattgagaac gtagctcttg gctgccatct cggggattat 7260taaggactgt gaactctatc cacaagccat ggcaatatct gtcccaccga atgctccctc 7320taacacactc ttactcccgt gatgtgtgtt aagggctccg atgatgctga aaacagcaca 7380ggatgtgaaa aggcaggaac agttctgaag tcaaaggctg atgtcctgtt tctctttccc 7440tctgtgaccg actcccttcc cagtggtaac aagtacccac agcttggttt gaatttctgc 7500acgctgttgt ctgtgcactc gctcacactt acgcacacag caggcatgtg ggcgatgctg 7560ggtattttgt gtatgagtgg gatgcacata cacacatcta catccatatc atgcccatgc 7620atctgtaact tgcttttccc gtgtaagaac acttcttaga gtttgttcaa tgcatgtgtc 7680tgtgtgaatg attgaaggca tttctaaccc attttaaaga tggctactta ggaccatatg 7740gatgttgtac tgatgtcatt tgaccacgtc cattgtttcc atcttttggg ctgttcttgt 7800gtattttact ttccatgtaa cactgtgaca ttgagaattg gtacctacaa cagtctattt 7860gctttacatt aaatttgtag gctaatttgt gtaaaaaaaa aaaaaaaaa 7909<210>22<211>1072<212>DNA<213>人<400>22agtcagtgaa acggcagaat cagaagaggt tccacaacca gaaaatcttg gctggaattt 60caccatcagg aataaaacag aaaaactaaa agagtgcccc agatagcctt tcttaggggc120ctgtgacagg tcgcaggaat cttgttggtg atccatccag atgttgtgtg ttctggaagt180ggacatcgcg gctctgtgtt tttgaagtca gatctcattg ctgtggtttc tatgcctgac240cccccgaagt tcttgctcct gttgccacag ggagccggga gagcacagag cgctgctccc300ggtgccctgc agccacacaa acatgctcct gctcctggcg gaggcagagc tgctgggaaa360gacatttcgg aagtttcctg tggctgcaac aaattgttca aatctgcact ggagcaccgc420tgtgacctgt ctttctccat cttagggcaa acagctcctg aaactggaaa ctccccagca480cctactcacc ctacccctca ggctctcctt gtgggggtgg ggcaggggga gttgtctgga540
atgcctggcc tctctgtcca agcatggcag ccttgcccca tgggtggtgc agactcagtt600tcccatgcac cttgccccag ggaggaggta ggggttcctt ccatagagat ggtgaagaat660aagggaggta gtgatcgtct ctgggatcca gttagatctg cgtttgcagg cagaaagagg720ctggggcaca tggagagagt gatcaactgg aagattctag ggtcctcaat tttgaaaggt780gacatgatac cctggaaagg gcatgaactt agttgtcagt tcgtccttgc cttttccaat840caatgctgtg tggccacggc aaattaatga acatctctga gtttcggtct cctgtctaaa900atgaggtgat aatagcttct tgaaggttgt aaggccccaa acatgctgcc tggcacatag960atggctaatc aatattttcc tacccttccc ttccttccct tctctggagt tgctacctgt 1020cttctcctgg ggccttgcaa ataaacttct gaattaaaaa aaaaaaaaaa aa 1072<210>23<211>417<212>DNA<213>人<400>23acctcccaac caagccctcc agcaaggatt caggagtgcc cctcgggcct cgccatgagg 60ctcttcctgt cgctcccggt cctggtggtg gttctgtcga tcgtcttgga aggcccagcc120ccagcccagg ggaccccaga cgtctccagt gccttggata agctgaagga gtttggaaac180acactggagg acaaggctcg ggaactcatc agccgcatca aacagagtga actttctgcc240aagatgcggg agtggttttc agagacattt cagaaagtga aggagaaact caagattgac300tcatgaggac ctgaagggtg acatccagga ggggcctctg aaatttccca caccccagcg360cctgtgctga ggactcccgc catgtggccc caggtgccac caataaaaat cctaccg 417<210>24<211>1011<212>DNA<213>人<400>24ttcctcatta aagtttcaca aataaagcac agcaagactt gtctgcagac acacaggagg 60cacacggaca gcccgtcaac cagagatgga gacgaaggcc agcatggctc tcacagggca120gcgcttctca gaacccctgg cccccctcgt gccaaggctg gcctgtgtca ggcctcgccc180acgccgcctt atgacaaata gargccggtg ccaaggaggt ggctacagag caggggcaag240gaagttatcc tcatgttctg ataatgaccc tgcaaatccc accccaccct caggcacctc300cgtctaaggt gtccggttac tccaggtaag gaggttccca ggagggccgt gttttcccta360
gggctgatga aacttgctcc gacaagccag gccactggga ggcacctcag gatggaaaag420atgctgagag gctttgctgg ctttcaggat gccgggwgcc ccacgggggc aaaaggggag480gaaggaaaga rattctaaag acagattgct gctggtctgt cccgacccag ggtcacagtg540tcagcaaaga gaacagcatg attctgacag ggttggattt tgtttcaccc tcggaatgag600cagacattca aacacttgca ttttcacgga aatcaacaag agagacagct agcaggacac660gaggctcctg ccagttctgt gtggaaaggc accagatggt ttgttatgaa acacattttg720gtcagaaaat agctggggtt ttttggttcc tgggaggaca acaaagctag aagaaaarga780ggtgtgagtt gcgtgaggag gaggcagaga agaaagcagc tttggcatca gacctgggtt840ctactcttca ctctacccct cmacgcttga ggcctcagtt tcctcatctg taaagtggtc900atagaatatt tccaaataaa tctaggtgtc aggtttcaca catymtccca ggaagtatgg960ggaggcgggg cgcagacact caaacggaca cacagaaacc agaggaagag c1011<210>25<211>2123<212>DNA<213>人<400>25tagctgatca tgtgacaatc caagatggcg gtgcccggcg aggcggagga ggaggcgaca 60gtttacctgg tagtgagcgg tatcccctcc gtgttgcgct cggcccattt acggagctat120tttagccagt tccgagaaga gcgcggcggt ggcttcctct gtttccacta ccggcatcgg180cctgagcggg cccctccgca ggccgctcct aactctgccc taattcctac cgacccagcc240gctgagggcc agcttctctc tcagacttcg gccaccgatg tccggcctct ctccactcga300gactctactc caatccagac ccgcacctgc tgctgcgtca tctcggtaag ggggttggct360caagctcaga ggcttattcg catgtactcg ggccgccggt ggctggattc tcacgggact420tggctaccgg gtcgctgtct catccgcaga cttcggctac ctacggaggc atcaggtctg480ggcccctttc ccttcaagac ccggaaggaa ctgcagagtt ggaaggcaga gaatgaagcc540ttcaccctgg ctgacctgaa gcaactgccg gagctgaacc caccagtgct gatgcccaga600gggaatgtgg ggactcccct gcgggtcttt ttggagttga tccgggcctg ccgcctaccc660cctcggatca tcacccagct gcagctccag ttccccaaga caggttcctc ccggcgctac720ggcaatgtgc cttttgagta tgaggactca gagactgtgg agcaggaaga gcttgtgtgt780acagcagagg gtgaagaaat accccaagga acctacctgg cagatatacc agccagcccc840
tgtggagagc ctgaggaaga agtggggaag gaagaggaag aagagtctca ctcagatgag900gacgatgacc ggggtgagga atgggaacgg catgaagcgc tgcatgagga cgtgaccggg960caggagcgga ccactgagca gctctttgag gaggagattg agctcaagtg ggagaagggt 1020ggctctggcc tggtgtttta tactgatgcc cagttctggc aggaggaaga aggagatttt 1080gatgaacaga cagccgatga ctgggatgtg gacatgagtg tgtactatga cagagatggt 1140ggagacaagg atgcccgaga ctctgtccaa atgcgtctag aacagagact ccgagatgga 1200caggaagatg gctctgtgat cgaacgccag gtgggcacct ttgagcgcca caccaagggc 1260attgggcgga aggtgatgga gcggcagggc tgggctgagg gccagggcct gggctgcagg 1320tgctcagggg tgcctgaggc cctggatagt gatggccaac accccagatg caagcgtgga 1380ttggggtacc atggagagaa gctacagcca tttgggcaac tgaagaggcc ccgtagaaat 1440ggcttggggc tcatctccac catctatgat gagcctctac cccaagacca gacggagtca 1500ctgctccgcc gccagccacc caccagcatg aagtttcgga cagacatggc ctttgtgagg 1560ggttccagtt gtgcttcaga cagcccctca ttgcctgact gaccgggttg ggggcttcct 1620ttcatagcta catgatgaaa accctctgcc ctggcctcat ctaccactga agcagaaagg 1680agtctgggag cagcagtctt cgtggctggt tcagggtgtt ttgttccgag cctgcctgcc 1740tgccggttct atacctcagg ggcattttta caaaaagccc cctcccgtcc cctccccttg 1800gatattaggg gtaacgaccg cttgtctttg gtctctaacc ctaatctctg ggcttgccct 1860ttgcctcctg cagaactttg aaaagctggg ttgagtgagg ctatcagcac agccttcctt 1920ggggactctg aaggtgtccc cacgaaggcc agaaaggggg aaagggacct gggcgaggag 1980aggatttgtg gtgcttggaa gagccggcct tgggtgggcc ctccaccgcc tctaccctca 2040ctgggtggga ctgccagcgg agagtccgcg ggaggtggct tgggtgtgcg acgtcacgga 2100agaataaaga cgtttactac tgg 2123<210>26<211>1276<212>DNA<213>人<400>26ggaatccacc cggggtgtgt ggattcctgc cctgttccca caggacagcc ctcaaccaat 60ggagacagga acctggagtt aaatgcttct ccctttttca ctgagagaga gacatgcaca120gtctgatgca ctttctttcc ttctttcttt ttctttcttt ttttttctta agacagagtc180
tctctctgtc accaaggctg gagtgcaggg gcacgatctg ggctcactgc cacctccacc240tcccgggttc aagcaattct cccacctcag cctcccgagt agctgggatt acaggcacta300gttaccacgc ccagctaatt tttgtatttt tagtagagat gcggtttcac catattggtc360aggctggtct cagactcctg atctcaggta atctgtctgc ctcagcctcc caaggtgctg420gaattacagg catgagccac cacacctggc cgtgatgcac tttctagatg ctgtcctaga480gatcacactg tgttaagcct cagttgcctt caatgtggtc atctctacag tataccctta540gcttttttct cctccgttac tttcccagac cctcactctg ctccctggat tcacttttcg600aaatagtcct cctgctgcaa agtcctgggc acctgcccta ctttcagcat tggaaggggg660gcccaggcta agaccatgag gccccactgt gggcgcccac agccccgttc ctccctctat720tcccaccaca gtcacatcct cctgtccctc agtgcttcct cgcctttccc tccagcccac780cgtgagatcc caggggacgg agcagcccct tctctgcccc agtgcagggc ttggccttag840cacacggtca gtctgtgctg gggtgaagtg atgaatgagt gagtggttga gtgataatgc900atcatcagat ctgtcttttc cacatgtctc tatctccacc cagaaccagt tttctcatcc960acaaatgggc atttgaggct gggtgctcct aaaccctaca aaattcagag ctggcacagt 1020tggggactga ccttccttga tctcacctca ctttctgtat ctataaaatg gggtaccttt 1080ctctaagagt aaaaaggagg cctggcatag ggaaagaaac tcagctcgag catccagaac 1140atccatcttg ctctcaaata cctaatacag gggaccatgt tttctgctat aattggtatt 1200ggagctggta ccatttatta aaggtaattc agttacaaag cttcaaaaaa aaaaaaaaaa 1260aaaaaaaaaa aaaaaa 1276<210>27<211>7764<212>DNA<213>人<400>27ccctgggatg gaggatctgt ctctctctct ctctctcctt tttttttttt tggtggagat 60gaaggggtgg gtctatggta catcacctga gttgtggggt aaatgtagag agtgtcaatc120aaaggcagag ctctcagagc tgggaaggag gctctagatg gcggctgtgc cttagagaga180gcgcgctctg ctccctgcct ttgcctcact ttacgcaact ttccctaact ttcgggcagc240ctcagggggc ccccgtagcc ccctgccttt cctagggact tactggggtc gattcgaacc300tttttttggg agaaaagcag cttttaggag ctttcttttc gtgccttgtt ggaaagaagc360
agccgtactg agagcccagg tcgttgtttt ttccagctta gaagccatgg cgcacctcca420tttttgtgcg ctctcctaat gaggtttttt ttctttcgga cctgttttag tattaattat480tgctttattt ttttgaccag ttaacatatt tgagggttat tttatttatt tttcgttttt540taacggagga ttttgccttt atttttaatt atttgggatc tgatattttt ctactagtag600ataggactct tggtttggac atactacatg gatcagtaaa tacctgggca caggacttca660aagcaaacac agattccccc tcccccttaa tatttaagaa ttaaaagatg atgagaaata720aggacaaaag ccaagaggag gacagttcgc tacacagcaa tgcatcgagt cactcagcct780ctgaagaagc ttcgggttca gactcaggca gtcagtcgga aagtgagcag ggaagtgatc840caggaagtgg acatggcagc gagtcgaaca gcagctctga atcttctgag agtcagtcgg900aatctgagag cgaatcagca ggttccaaat cccagccagt cctcccagaa gccaaagaga960agccagcctc taagaaggaa cggatagctg atgtgaagaa gatgtgggaa gaatatcctg 1020atgtttatgg ggtcaggcgg tcaaaccgaa gcagacaaga accatcgcga tttaatatta 1080aggaagaggc aagtagcggg tctgagagtg ggagcccaaa aagaagaggc cagaggcagc 1140tgaaaaaaca agaaaaatgg aaacaggaac cctcagaaga tgaacaggaa caaggcacca 1200gtgcagagag tgagccagaa caaaaaaaag taaaagccag aagacctgtc cccagaagaa 1260cagtgcccaa acctcgtgtt aaaaagcagc cgaagactca gcgtggaaag agaaaaaagc 1320aagattcttc tgatgaggat gatgatgatg acgaagctcc caaaaggcag actcgtcgaa 1380gagcggctaa aaacgttagt tacaaagaag atgatgactt tgagactgac tcagatgatc 1440tcattgaaat gactggagaa ggagttgatg aacagcaaga taatagtgaa actattgaaa 1500aggtcttaga ttcaagactg ggaaagaaag gagccactgg agcatctact actgtatatg 1560cgattgaagc taatggcgac cctagtggtg actttgacac tgaaaaggat gaaggtgaaa 1620tccagtacct catcaagtgg aagggttggt cttacatcca cagcacatgg gagagtgaag 1680aatccttaca gcaacagaaa gtgaagggcc taaaaaaact agagaacttc aagaaaaaag 1740aggacgaaat caaacaatgg ttagggaaag tttctcctga agatgtagaa tatttcaatt 1800gccaacagga gctggcttca gagttgaata aacagtatca gatagtagaa agagtaatag 1860ctgtgaagac aagtaaatct acattgggtc aaacagattt tccagctcat agtcggaagc 1920cggcaccctc aaatgagccc gaatatctat gtaaatggat gggactcccc tattcagagt 1980gtagctggga agatgaagcc ctcattggaa agaaattcca gaattgcatt gacagcttcc 2040
acagtaggaa caactcaaaa accatcccaa caagagaatg caaggccctg aagcagagac 2100cacgatttgt agctttaaag aaacaacctg catatttagg aggggagaat ctggaacttc 2160gagattatca gctagaaggt ctaaactggc tagctcattc ctggtgcaaa aataatagtg 2220taatccttgc tgatgaaatg ggcctaggaa agaccatcca gaccatatca ttcctctcct 2280acctgttcca ccaacaccag ctgtatggcc cctttcttat agtcgtccct ttatccaccc 2340tcacctcatg gcagagagag tttgaaatct gggcaccaga gattaacgta gtggtttaca 2400taggtgacct gatgagcaga aatacgatac gggaatatga atggattcat tcccaaacca 2460aaagattgaa gttcaacgca cttataacaa catatgagat cctcttgaaa gataagactg 2520tgctgggcag tattaactgg gcctttctgg gagtggatga agcccatcgg ttgaagaatg 2580atgactcttt attgtataaa actctgattg atttcaagtc caaccatagg ctcctgatta 2640cggggacccc tcttcagaat tccctcaaag agctctggtc cttgctgcac tttattatgc 2700cggagaagtt tgaattttgg gaagattttg aagaagacca tgggaagggg agagagaatg 2760gctaccagag tcttcataag gtgctagagc ctttccttct ccggagagtc aaaaaagatg 2820tggagaaatc ccttcctgct aaagtggaac agattctcag ggtggagatg tcagcccttc 2880agaaacagta ttacaagtgg attctgacca ggaattacaa ggctcttgcc aaaggaacaa 2940gaggcagcac atctggtttt cttaatattg tgatggaact gaaaaaatgt tgcaaccact 3000gctatctgat taaaccccct gaagaaaatg aaagggaaaa tggacaggag attcttctgt 3060ccctcataag gagcagtggg aagttgattt tattagacaa actgttgaca agacttcgag 3120aaagggggaa tcgagtgctt atcttctctc agatggtgag aatgttggat atcctggctg 3180aatacctaac tattaaacac tatcctttcc agcgtctgga tggttccatc aagggagaaa 3240tccgaaaaca ggcactggac cacttcaatg cagatgggtc tgaggacttc tgtttcctgc 3300tctcgacaag ggctggtggc ctgggaatca atttggcttc agcggacaca gtcgtcatct 3360ttgactctga ctggaacccc cagaatgact tgcaggcaca agcccgagcg catagaattg 3420gtcagaagaa gcaggtaaat atttaccgct tagttacaaa ggggactgtg gaggaggaga 3480tcatagaacg ggccaaaaag aagatggtat tagatcatct ggtgattcag cgcatggaca 3540ccactggccg gacgatcctg gaaaacaact caggaaggtc caactcaaat ccttttaata 3600aagaagagct gacagctatt ttgaaatttg gagcagagga tctcttcaaa gaactggaag 3660gggaggaatc agaacctcag gaaatggata tagatgaaat tttgcggttg gctgaaacga 3720gagagaatga agtgtcaaca agtgcaacag atgaacttct atcacagttt aaggttgcca 3780
actttgcaac aatggaagat gaagaagagc tagaagagcg tcctcacaag gactgggatg 3840agatcattcc agaggaacaa aggaaaaaag tagaggagga agagcggcag aaggagctag 3900aagaaattta tatgctgcct cgaattcgga gttccactaa aaaggctcag acaaatgaca 3960gtgactctga cactgagtct aagaggcagg cccagagatc ctctgcttct gagagtgaaa 4020cggaagactc tgatgatgac aagaagccaa agcgcagagg gcgtccgagg agtgtgcgga 4080aggacctcgt ggagggattt actgatgcag agatccgaag gttcatcaag gcttataaga 4140agtttggtct ccctcttgaa cggctggagt gcttagcacg tgatgctgag ctggtagata 4200agtcggtggc agatctgaag cgcctgggtg aactgatcca caacagctgt gtgtcagcaa 4260tgcaggaata tgaagagcag ctgaaagaaa atgccagcga gggaaaagga ccagggaaaa 4320ggagaggtcc aacaatcaag atatccggag ttcaggttaa tgtgaaatcc attatccaac 4380atgaagagga gtttgagatg ctgcataaat ctatccctgt ggaccctgaa gaaaaaaaaa 4440aatactgctt aacctgtcgt gtcaaagctg cacattttga tgtagagtgg ggggtggaag 4500atgattctcg cctgttgctg gggatttatg aacatggcta tggaaactgg gagttaatta 4560aaacagaccc agagcttaaa ttaactgaca aaattctgcc ggtggagaca gataaaaagc 4620ctcaggggaa gcagctacag acccgagcgg attacttgtt gaagctgctc agaaagggtc 4680tggagaagaa gggggctgtg acaggtgggg aggaggccaa attaaagaag cggaagcctc 4740gggtaaagaa ggaaaacaaa gtgcccaggc tgaaagagga gcatggaatt gagctttcat 4800ctcctaggca ttcagataat ccatcagaag agggagaagt gaaagatgat ggcttggaaa 4860aaagtccaat gaaaaaaaaa cagaagaaga aagagaacaa ggagaacaag gagaaacaaa 4920tgagttctag gaaagacaaa gaaggggaca aggaaagaaa gaagtcaaaa gataagaaag 4980agaagcctaa aagtggtgat gccaaatctt cgagtaaatc aaagcgatct cagggtcctg 5040tccatattac agcaggaagt gaacctgtcc ccattggaga ggatgaggat gatgatctgg 5100accaggagac attcagcata tgtaaggaga ggatgaggcc cgtgaaaaag gcactgaaac 5160agctcgacaa acctgacaag gggctcaacg tgcaagaaca gctggaacac acccggaact 5220gcctgctgaa aatcggagac cggatagccg agtgccttaa agcctactca gatcaggagc 5280acatcaaact ctggaggagg aacctatgga tttttgtttc caagtttaca gaatttgatg 5340ctcgaaaact gcataagtta tacaagatgg ctcataagaa aaggtctcaa gaagaagagg 5400agcaaaagaa gaaagacgac gtgactgggg gtaagaaacc atttcgtcca gaggcctcag 5460
gctccagccg ggactctctg atatctcagt cccatacctc acacaacctt caccctcaga 5520agcctcattt gcctgcctcc catggcccac agatgcatgg acacccaaga gataactaca 5580atcaccccaa caagagacac ttcagtaatg cagatcgagg agactggcag agggaaagaa 5640agttcaacta tggtggtggc aacaacaatc caccatgggg aagcgacagg caccatcagt 5700atgagcagca ctggtacaag gaccaccatt atggggaccg gcgacatatg gatgcccacc 5760gttccggaag ctatcgaccc aacaacatgt ccagaaagag gccttatgac cagtacagca 5820gtgaccgaga ccaccgggga cacagagatt attatgacag gtatgcaaaa ggctgtgaga 5880caccaggtgc caacctttgc caggagctgt ttctagggag aaagtgacgt atacatgaat 5940gtatttatct atcaaattac tgaagatctc atcatgcatg tgtcagccac agcgaatccc 6000atgtcttggt tataggtttt atgttttgtt ttctgggtca tagggagcac atttcacctg 6060tgcaggaaaa gagttttctg ccgtcttttg aggaaatcta gtgaagaggt cgccataaaa 6120tattagagtc aacaaccaaa attattaagc tctgtgcgag gctgtcagcc acactaggta 6180tcagggatcc cgagatgggt accagcccac agtccttacc tgccacgagc ccataattga 6240agagtcaaag tcttctgaag ctgcaccctc tttacttcag tacaatgcca ccagtagtac 6300gatgagccaa agctttacat tgtgagagta gcaagtccag ggagagctaa agaggtttta 6360tctgtatttc ctaatttcaa atcttggata atttaacctc atagcagctt tggttttccc 6420tgggctgatg atgtgcgtca tttgcactgt accttgaatt tacagtggga aaatttcata 6480taaacgtgtc aaagtcgtgc tttgtttttg gaagatctgg taacagcagc ccgcattagc 6540agagagctgt agctgagtag ctgccacctc gttgggagac tgcccctcgc tcccaccctt 6600ctctattgtc tggacccagt gggcatcttg ccctgcgttc ttctagtagg tctgtatttc 6660tatttgatgt cactttcctt ttgcctgaag gactttttct gctggtgata aactctttca 6720gtgtttgtat atatgcctga aaaagtattt tgccttcatt tttgaaagta gtttttgctg 6780agtgtataca tttttggctt tacagtttct ttcagtgctt taaagatgta cctctgctat 6840ttacttgcat tgttttgtga tgaaaaatct gtcatcctta tctttgttcc tctttacata 6900atgttccttt taaaaaaaat cactgattat gatgtgcctt ggtgtatttt tccttggttt 6960cttgtgcttg gaaatttttg aacttcttgg atctgtgggt ttattgtttc cataaaattt 7020ggaaattttt acaatcttct tcaaatattt tttctgatcc cccactctct cttcttcttt 7080ggagattctc attacaccta tattagcttg cttgaagttg tctcacagct cacttgtatt 7140ctgttgactt ttaaaaaatt atgctttctg tttcactgtg gatagtttct attgctacct 7200
cttcaagttc actaatactt tccttttcaa tgtcaagact gctgtgaggc ccatccagtg 7260tactttgcat tttatacatt gtagttctaa aagttcggaa agttgttttt gggtcttttt 7320atatatgttc tgtgtctaac cttttaaaac ctggaacaca gatataacaa tggttttgat 7380gtccttgtct gcgaatctta tcacttgggt cagtttcagt tgatacctcc tcactgtggg 7440tcttgctccc ctggtgcttt ctgtgcctag taatttttgt cagatgccag atgtaacatt 7500taccttgttg ggtgctggat atttctgtat tcctgtaagt attctggagc tttgttatga 7560gttgcaggtt atttggaagc agtttccttt ttcaggtctt gctgttaaga ttcgttaggt 7620agaaccagag cagtgctcag tcaagggcta atgattgccc acccccaagg taaagagcct 7680cattgcactc tacccaattg cgttagtctg ttttgcagga atacctgagg ctgggtaatt 7740tatagagaaa agagttttat ttgg 7764<210>28<211>3000<212>DNA<213>人<400>28ggcagcgtcc gcgggaggtg aggtggctgt ggggacccag gtggcctctt ccctggggcc 60ttgctaatga cggcaaaatc cgggttctgc caaaatatat ttaaaaaggt ttattcctag120tcagtatgag tgactgtggc ccaggttatt cagcctcaag aggtcctgtg aaagtgcccg180agatggtcag gcttgcaggt taattttata caattcaggg agacaggaat ttcaggtaaa240gtcataaatc aggctgagca gtgtggctca tgcctgtggt cccagcactt tgggaggcca300ggagttccag agcagcctgg gcagcacagc aagaccctgt ctctacatga aattagaaaa360ataaaaaaat tagcggggcg tggtgtccca tgcctgtggc ctcagctact tgggaggccc420agtcagttga gtccaggagg tggaggctgt aaccagctat gttggctgca ctgcacgcta480gcctgggtaa cacagcgaga tcctgcctcc aaaaagaaaa tcataaatca ataagagaaa540gatatacacg ggttcctccc aaaaagctgg tatatctcca aagggtttac acctcatggg600ggcacttagg gattctttag tggacagttg gttgagagac ttaagctact gcctgaagac660tggaatcaga agcatgccag agttaagggg attgcgtaga tcaaagttct tattatgtag720atgaagcctc ttagttggca actctcagaa tagatggtaa atgtctgttt tcagtttttt780gggtttttgt gtttttgttt ttgtttttag agagagtctt gctctgtcgc ccaggctaga840gtgcagtggc gtgatctcag ctcactgcaa cctccacctc ccaggtttga gcggttctcc900
tgcctcggcc tcctgggtag ctgggactac gggcgcccgc caccacgcct ggctaatttt960tgtattttta gtggagatgg ggtttcacca tgttgctgag gctggtcttg acttcctgac 1020ctcaggtgat ccgcccacct ctacctccca aagtgctggg attacaggcg tgggccaccg 1080cgcgtcaggc tggctgtctc ttccagacct aagaaaggct tagaacaaag gaggtctggc 1140tacattaatg gagattcgct gcagatgcaa attttcccac taaagatagc tttgcggggc 1200tatccatttc aatctgttgc ccctgtggca gccacttcaa aacatgtcaa agaagtatat 1260tttggggtaa aataatttcc ttcagcatct gctgtcatgt gatgctgtac cagagtcagg 1320ttggaaagtg agcctcatta tataagagta ataaaactca tctgatgaga ttttatggtt 1380tctcgggcag gattccccaa gcctcataca taggcatttg ggcaagggaa aaaaggtgaa 1440tttagtcctc accaggttgg tagggcttcc tcggttattg gagtgggagt aacagcaacc 1500attgggccca gcagtttttt taaatgtctc tggggctgtg gactgaccat ccaaataact 1560gattttaatc atttcattat ggaaaaattg tcagcagaac ccccaagtag agagacccat 1620cagtcaagat atacctcatg accttgcaag ctaatctagc ttgacccaga tcccctccta 1680atctgtgcag attcattgag gaatgtcata gccatgccta ctggttaaga catagtcctt 1740tacagtgaga gttgaaaccc aagctctatc actttcttgg ctgtgttgct ttgagaaagg 1800catttaaatg ttttgtgcct gtttcctcat ctgaaattgg tgggtaatag tcacttcata 1860ggacagttgt gaagattgaa tgcagaaaaa tttgtgccac gcctggaacc gtccctggca 1920tatattaaat tctaaaaaag tgttaaatat tataatgaat atcaacactt ccttattctg 1980gaagcaccga caggatatgc tgtgtttagt gttagcatca tgtcaggaca gggtctgttg 2040cgatgcccac actcaggatc tgttcccagg aacctgcgta aagttttctt ctctggaaga 2100ctttgggtcc ttttttttta acaagaagag gctctaccct gggactggga atttccaagg 2160ccacctttga ggatcgcaga gctcatttta gagccatttt agtccccagc tcctcttcct 2220ccactcccac gttacccgtg agaggactgt ctgcagggta agggaggaca gcccaacccc 2280aggtggggac ttcttatgta ttgccttcct gcagtgcctt ctctgcccta aaccatggtg 2340ggtttccttt gctaatgtct gacatcttgt gccctacact gtcccatctg aggctcagaa 2400cctctcagcc ggttctcatg gggaacgttc cccagatctg atgccctcat tcaggacact 2460tccatcattg tccctacatt tcttctctca gtgctttatt caggctgctg cattcgtggt 2520gcagaccagg tcttgtaaaa aattattcag tcagcatgtg ctgagccatt gtcctgtccc 2580
agggacaggg ctttatagtc attgccctat tcatctcttc aaccaatgtg gaagttagga2640attggaatcc ccatttcaca gactaagaag tggcgtgtta atcagttgaa ataattttta2700cggcttggcg tggtggccca tacctgtaat cccagcactt tgggaggccg gggcgggcgg2760attacctgag gccaggggtt cgagaccagc ctggccaaca tggtgaaacc tcatctctgc2820tgggaataca gaaattagcc aggcatggtg gctcacgcct gtagtcccaa ctgctctgga2880gcctgaagca ggataatcgc ttgaatccag gagatggagg ttgcagtgag cagagagcat2940gccactgcac tacagcctga gcaagagtga gactccgtca caaaaaaaaa aaaaaaaaaa3000<210>29<211>489<212>DNA<213>人<400>29agagccgcag gtcagtcgtg aagagggagc tctattgcca ccatgagttt ctccggcaag 60taccaactgc agagccagga aaactttgaa gccttcatga aggcaatcgg tctgccggaa 120gagctcatcc agaaggggaa ggatatcaag ggggtgtcgg aaatcgtgca gaatgggaag 180cacttcaagt tcaccatcac cgctgggtcc aaagtgatcc aaaacgaatt cacggtgggg 240gaggaatgtg agctggagac aatgacaggg gagaaagtca agacagtggt tcagttggaa 300ggtgacaata aactggtgac aactttcaaa aacatcaagt ctgtgaccga actcaacggc 360gacataatca ccaataccat gacattgggt gacattgtct tcaagagaat cagcaagaga 420atttaaacaa gtctgcattt catattattt tagtgtgtag aattaatgta ataaagtgaa 480ctttgtttt 489<210>30<211>1699<212>DNA<213>人<400>30aggtgagcgg ttgctcgtcg tcggggcggc cggcagcggc ggctccaggg cccagcatgc 60gcgggggacc ccgcggccac catgtatgtg ggctatgtgc tggacaagga ttcgcccgtg120taccccggcc cagccaggcc agccagcctc ggcctgggcc cggcaaacta cggccccccg180gccccgcccc cggcgccccc gcagtacccc gacttctcca gctactctca cgtggagccg240gcccccgcgc ccccgacggc ctggggggcg cccttccctg cgcccaagga cgactgggcc300gccgcctacg gcccgggccc cgcggcccct gccgccagcc cagcttcgct ggcattcggg360
ccccctccag actttagccc ggtgccggcg ccccctgggc ccggcccggg cctcctggcg420cagcccctcg ggggcccggg cacaccgtcc tcgcccggag cgcagaggcc gacgccctac480gagtggatgc ggcgcagcgt ggcggccgga ggcggcggtg gcagcggtaa gactcggacc540aaggacaagt accgcgtggt ctacaccgac caccaacgcc tggagctgga gaaggagttt600cattacagcc gttacatcac aatccggcgg aaatcagagc tggctgccaa tctggggctc660actgaacggc aggtgaagat ctggttccaa aaccggcggg caaaggagcg caaagtgaac720aagaagaaac agcagcagca acagccccca cagccgccga tggcccacga catcacggcc780accccagccg ggccatccct ggggggcctg tgtcccagca acaccagcct cctggccacc840tcctctccaa tgcctgtgaa agaggagttt ctgccatagc cccatgccca gcctgtgcgc900cgggggacct ggggactcgg gtgctgggag tgtggctcct gtgggcccag gaggtctggt960ccgagtctca gccctgacct tctgggacat ggtggacagt cacctatcca ccctctgcat 1020ccccttggcc cattgtgtgc agtaagcctg ttggataaag accttccagc tcctgtgttc 1080tagacctctg ggggataagg gagtccaggg tggatgatct caatctcccg tgggcatctc 1140aagccccaaa tggttggggg aggggcctag acaaggctcc aggccccacc tcctcctcca 1200tacgttcaga ggtgcagctg gaggcctgtg tggggaccac actgatcctg gagaaaaggg 1260atggagctga aaaagatgga atgcttgcag agcatgacct gaggagggag gaacgtggtc 1320aactcacacc tgcctcttct gcagcctcac ctctacctgc ccccatcata agggcactga 1380gcccttccca ggctggatac taagcacaaa gcccatagca ctgggctctg atggctgctc 1440cactgggtta cagaatcaca gccctcatga tcattctcag tgagggctct ggattgagag 1500ggaggccctg ggaggagaga agggggcaga gtcttcccta ccaggtttct acacccccgc 1560caggctgccc atcagggccc agggagcccc cagaggactt tattcggacc aagcagagct 1620cacagctgga caggtgttgt atatagagtg gaatctcttg gatgcagctt caagaataaa 1680tttttcttct cttttcaaa1699<210>31<211>2612<212>DNA<213>人<400>31gctgatagca cagttctgtc cagagaagga aggcggaata aacttattca ttcccaggaa 60ctcttggggt aggtgtgtgt ttttcacatc ttaaaggctc acagaccctg cgctggacaa120
atgttccatt cctgaaggac ctctccagaa tccggattgc tgaatcttcc ctgttgccta180gaagggctcc aaaccacctc ttgacaatgg gaaactgggt ggttaaccac tggttttcag240ttttgtttct ggttgtttgg ttagggctga atgttttcct gtttgtggat gccttcctga300aatatgagaa ggccgacaaa tactactaca caagaaaaat ccttgggtca acattggcct360gtgcccgagc gtctgctctc tgcttgaatt ttaacagcac gctgatcctg cttcctgtgt420gtcgcaatct gctgtccttc ctgaggggca cctgctcatt ttgcagccgc acactgagaa480agcaattgga tcacaacctc accttccaca agctggtggc ctatatgatc tgcctacata540cagctattca catcattgca cacctgttta actttgactg ctatagcaga agccgacagg600ccacagatgg ctcccttgcc tccattctct ccagcctatc tcatgatgag aaaaaggggg660gttcttggct aaatcccatc cagtcccgaa acacgacagt ggagtatgtg acattcacca720gcgttgctgg tctcactgga gtgatcatga caatagcctt gattctcatg gtaacttcag780ctactgagtt catccggagg agttattttg aagtcttctg gtatactcac caccttttta840tcttctatat ccttggctta gggattcacg gcattggtgg aattgtccgg ggtcaaacag900aggagagcat gaatgagagt catcctcgca agtgtgcaga gtcttttgag atgtgggatg960atcgtgactc ccactgtagg cgccctaagt ttgaagggca tccccctgag tcttggaagt 1020ggatccttgc accggtcatt ctttatatct gtgaaaggat cctccggttt taccgctccc 1080agcagaaggt tgtgattacc aaggttgtta tgcacccatc caaagttttg gaattgcaga 1140tgaacaagcg tggcttcagc atggaagtgg ggcagtatat ctttgttaat tgcccctcaa 1200tctctctcct ggaatggcat ccttttactt tgacctctgc tccagaggaa gatttcttct 1260ccattcatat ccgagcagca ggggactgga cagaaaatct cataagggct ttcgaacaac 1320aatattcacc aattcccagg attgaagtgg atggtccctt tggcacagcc agtgaggatg 1380ttttccagta tgaagtggct gtgctggttg gagcaggaat tggggtcacc ccctttgctt 1440ctatcttgaa atccatctgg tacaaattcc agtgtgcaga ccacaacctc aaaacaaaaa 1500agatctattt ctactggatc tgcagggaga caggtgcctt ttcctggttc aacaacctgt 1560tgacttccct ggaacaggag atggaggaat taggcaaagt gggttttcta aactaccgtc 1620tcttcctcac cggatgggac agcaatattg ttggtcatgc agcattaaac tttgacaagg 1680ccactgacat cgtgacaggt ctgaaacaga aaacctcctt tgggagacca atgtgggaca 1740atgagttttc tacaatagct acctcccacc ccaagtctgt agtgggagtt ttcttatgtg 1800
gccctcggac tttggcaaag agcctgcgca aatgctgtca ccgatattcc agtctggatc1860ctagaaaggt tcaattctac ttcaacaaag aaaatttttg agttatagga ataaggacgg1920taatctgcat tttgtctctt tgtatcttca gtaattgagt tataggaata aggacggtaa1980tctgcatttt gtctctttgt atcttcagta atttacttgg tctcgtcagg tttgagcagt2040cactttagga taagaatgtg cctctcaagc cttgactccc tggtattctt tttttgattg2100cattcaactt cgttacttga gcttcagcaa cttaagaact tctgaagttc ttaaagttct2160gaagttctta aagcccatgg atcctttctc agaaaaataa ctgtaaatct ttctggacag2220ccatgactgt agcaaggctt gatagcagag gtttggtggt tcagagttat acaactaatc2280ccaggtgatt ttatcaattc cagtgttacc atctcctgag ttttggtttg taatcttttg2340tccctcccac ccccacagaa gatttcctaa gtagggtgac tttttaaata aaaatttatt2400gaataattaa tgataaaaca taataataaa cataaataat aaacaaaatt accgagaacc2460ccatccccat ataacaccaa cagtgtacat gtttactgtc acttttgata tggtcttatc2520cagtgtgaac agcaatttat tatttttgct catcaaaaaa taaaggattt tttttcactt2580gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2612<210>32<211>3345<212>DNA<213>人<400>32gaattccgtc tcgaccactg aatggaagaa aaggactttt aaccaccatt ttgtgactta 60cagaaaggaa tttgaataaa gaaaactatg atacttcagg cccatcttca ctccctgtgt120cttcttatgc tttatttggc aactggatat ggccaagagg ggaagtttag tggacccctg180aaacccatga cattttctat ttatgaaggc caagaaccga gtcaaattat attccagttt240aaggccaatc ctcctgctgt gacttttgaa ctaactgggg agacagacaa catatttgtg300atagaacggg agggacttct gtattacaac agagccttgg acagggaaac aagatctact360cacaatctcc aggttgcagc cctggacgct aatggaatta tagtggaggg tccagtccct420atcaccatag aagtgaagga catcaacgac aatcgaccca cgtttctcca gtcaaagtac480gaaggctcag taaggcagaa ctctcgccca ggaaagccct tcttgtatgt caatgccaca540gacctggatg atccggccac tcccaatggc cagctttatt accagattgt catccagctt600cccatgatca acaatgtcat gtactttcag atcaacaaca aaacgggagc catctctctt660
acccgagagg gatctcagga attgaatcct gctaagaatc cttcctataa tctggtgatc720tcagtgaagg acatgggagg ccagagtgag aattccttca gtgataccac atctgtggat780atcatagtga cagagaatat ttggaaagca ccaaaacctg tggagatggt ggaaaactca840actgatcctc accccatcaa aatcactcag gtgcggtgga atgatcccgg tgcacaatat900tccttagttg acaaagagaa gctgccaaga ttcccatttt caattgacca ggaaggagat960atttacgtga ctcagccctt ggaccgagaa gaaaaggatg catatgtttt ttatgcagtt 1020gcaaaggatg agtacggaaa accactttca tatccgctgg aaattcatgt aaaagttaaa 1080gatattaatg ataatccacc tacatgtccg tcaccagtaa ccgtatttga ggtccaggag 1140aatgaacgac tgggtaacag tatcgggacc cttactgcac atgacaggga tgaagaaaat 1200actgccaaca gttttctaaa ctacaggatt gtggagcaaa ctcccaaact tcccatggat 1260ggactcttcc taatccaaac ctatgctgga atgttacagt tagctaaaca gtccttgaag 1320aagcaagata ctcctcagta caacttaacg atagaggtgt ctgacaaaga tttcaagacc 1380ctttgttttg tgcaaatcaa cgttattgat atcaatgatc agatccccat ctttgaaaaa 1440tcagattatg gaaacctgac tcttgctgaa gacacaaaca ttgggtccac catcttaacc 1500atccaggcca ctgatgctga tgagccattt actgggagtt ctaaaattct gtatcatatc 1560ataaagggag acagtgaggg acgcctgggg gttgacacag atccccatac caacaccgga 1620tatgtcataa ttaaaaagcc tcttgatttt gaaacagcag ctgtttccaa cattgtgttc 1680aaagcagaaa atcctgagcc tctagtgttt ggtgtgaagt acaatgcaag ttcttttgcc 1740aagttcacgc ttattgtgac agatgtgaat gaagcacctc aattttccca acacgtattc 1800caagcgaaag tcagtgagga tgtagctata ggcactaaag tgggcaatgt gactgccaag 1860gatccagaag gtctggacat aagctattca ctgaggggag acacaagagg ttggcttaaa 1920attgaccacg tgactggtga gatctttagt gtggctccat tggacagaga agccggaagt 1980ccatatcggg tacaagtggt ggccacagaa gtaggggggt cttccttaag ctctgtgtca 2040gagttccacc tgatccttat ggatgtgaat gacaaccctc ccaggctagc caaggactac 2100acgggcttgt tcttctgcca tcccctcagt gcacctggaa gtctcatttt cgaggctact 2160gatgatgatc agcacttatt tcggggtccc cattttacat tttccctcgg cagtggaagc 2220ttacaaaacg actgggaagt ttccaaaatc aatggtactc atgcccgact gtctaccagg 2280cacacagact ttgaggagag ggcgtatgtc gtcttgatcc gcatcaatga tgggggtcgg 2340ccacccttgg aaggcattgt ttctttacca gttacattct gcagttgtgt ggaaggaagt 2400
tgtttccggc cagcaggtca ccagactggg atacccactg tgggcatggc agttggtata 2460ctgctgacca cccttctggt gattggtata attttagcag ttgtgtttat ccgcataaag 2520aaggataaag gcaaagataa tgttgaaagt gctcaagcat ctgaagtcaa acctctgaga 2580agctgaattt gaaaaggaat gtttgaattt atatagcaag tgctatttca gcaacaacca 2640tctcatccta ttacttttca tctaacgtgc attataattt tttaaacaga tattccctct 2700tgtcctttaa tatttgctaa atatttcttt tttgaggtgg agtcttgctc tgtcgcccag 2760gctggagtac agtggtgtga tcccagctca ctgcaacctc cgcctcctgg gttcacatga 2820ttctcctgcc tcagcttcct aagtagctgg gtttacaggc acccaccacc atgcccagct 2880aatttttgta tttttaatag agacggggtt tcgccatttg gccaggctgg tcttgaactc 2940ctgacgtcaa gtgatctgcc tgccttggtc tcccaataca ggcatgaacc actgcaccca 3000cctacttaga tatttcatgt gctatagaca ttagagagat ttttcatttt tccatgacat 3060ttttcctctc tgcaaatggc ttagctactt gtgtttttcc cttttggggc aagacagact 3120cattaaatat tctgtacatt ttttctttat caaggagata tatcagtgtt gtctcataga 3180actgcctgga ttccatttat gttttttctg attccatcct gtgtcccctt catccttgac 3240tcctttggta tttcactgaa tttcaaacat ttgtcagaga agaaaaaagt gaggactcag 3300gaaaaataaa taaataaaag aacagccttt tgcggccgcg aattc 3345<210>33<211>1201<212>DNA<213>人<220>
<221>misc_feature<222>(532)..(532)<223>w equals a or t<400>33wttatwahaa atttattttt aacccaatag aaaagcaaat ttggaatcta tttacaagta 60ctatatattt acatatatac agttagagtg ggagatttaa agaaaatggg cagagaaaca120caatataaat caaagaatat gccactgtac aaggcattat tatcattatc atggtcctta180atgttactga acctttacta tagtaataaa tacagttcta tatttacaca tcttataaaa240catctcataa atgtattttt tcaaatccaa gthaaaacat ctgatcaaaa taaacatgct300tatataaaaa taaatctacc taacagccat ttggtttgga tgtattgarg ctaatatagg360
ataatagagg gtaagrbtta atactttgac ttttcttatt taataacttg cttcttaaaa420tacctaacac agtattaata tggaatargc rgagargtaa tgttcctaac atcaagtggg480ttatccagag agaacacagc taaaaccaag ctaaataaac aggataatac gttactgagt540ctcttgagtc caaagtggtg tcagatattg ggtttgccag agctactaga gatacatgtg600tgagaggttg tatcagtgga cttaatttat gtgatgtgca catttgatca ttaagatgca660catcagtttg aatcaactga taaaacttat tgcaaaaatt ctttactaac ccagaaaaaa720aatcccagat tgcttacttt cttttccagg tatgtycatt gctggcagtg gaattccctt780ctgagctttg ggcmcaagga gttaaaaaca aatcagataa gacatacgtc acctgtscat840gattscctta gtaacaattt aagaattttg gtcagttttt ctttcaaaat acttgtaagc900agttttatcc catgakggtg gaccatctag tgctgataca taaamctggt atctctaaaa960wtgatctcaa tatgagtgag taacaatacy twacattacc ayctaaggga ttgtscttag 1020aaggatcttt cysmkkaags aaasgwggat haaaathtca awkktattwt attwatccaw 1080ttwaaaychm haaaataaat ttttattwaa ccawatttcy aatcccmaaa ccyttttttt 1140tttttaaaaa aattttatat tamcbkktcm tkyyktaaam dttttttaaa atttaaattw 1200a 1201<210>34<211>2778<212>DNA<213>人<400>34ctcattttga tgtctagaat caggggatcc aggatcatca ccaaggtcat tttcccaggt 60atggaggggt ctttctgctt ctttcttgtc atgcacagct gctgaggaag gggctgggag120taaagacagt gaaatgggga ggaggagtcc attcaaaccg agaaacaaag tgtttggttt180ttcttacccc tggtgtagaa gctaccaacc ttttccaaga aagagggcct ggcccccttc240tcgggtctgg ctgggtgcct gctgtgcctc tctggcctcc cctccgaagg gcaccattcc300ctcgggtgag tactaccggc ctgcaccgtc ttccagtggg gacagcctga gaagagagtc360tggggcctta cttcagtacc ttccttcact ggcctcaccc tgtgcaaatc atgccacacg420ctgcagcctc cttttcccta tctataaaat aaaaatgacc ctgctctatc tcactgggct480ggcaagaaca cactgttgtt gccttgcaga cagatgtgct gaggctgtag aaagtgcttt540ttatttggtt gggagcttgt gcataaatgc gagaggggct gcacatctga cggactagag600
gtgactcatg gctgaaccgg aacaggacat cggggagaag ccagcagcca tgctgaactc660tccacagggc cctgtgaaaa gctcttcacc tcctctgccc tctggatcta gtgaagccta720ttcatccttc agatgtcagc tcaaataatc aaccttcatg gaggcctccc ttgaccccta780acatgctttc aaagtactgt gtatttcaca ttcatcatgc cccgacaact gtgatttccc840atttattaat atctgtctct tctgctggcc tgcaaactcc aggagcacag agacatcttt900gggatttttg aacatgattt ccccagggct tagcccagtg cctggtgcaa agcaggcttt960caacatgttc agtggatatt gtaagaaaga aagaaataca caaaaggcct ggcatatgca 1020aagcactcta aatattcact cctttccctt ccctctgggt gagaaaattt ctccttataa 1080agacaccctc ctaactgtat ctctgctaga gaactgaaga cataaagcac tctgtgccaa 1140aaatatttaa gtaaaaactt gagctaagca cagagattat aaatatttct tccccagatt 1200acgcaccatt taaaaatact gtctcagctc cttttcatga tttgggtggt gattaaagaa 1260aattactctt caagactgaa agtcattact gcccttttcc tgacttgcct tttcccttga 1320gaaggggagg ataagctgca gggcaggaag tggaagtggg gcatccttgt cctttgtctg 1380gcagacagcc aactggtcag gtactgctcc ttctcaactc tttcctgatt cccaggtgaa 1440tataaacaag aaggcacaaa tccacacttg ccaacaacgg acccaagtga taacaagaaa 1500cccagtgaca cctgtctagg tgaagactca gcccctatgt gaccaggttg caaagccaaa 1560ctgaccatct gctttccatt tggactttta gttcatactg tatcttctca ggacagttaa 1620gttggaatac aatgccactg tcctgaaaga tggtagaatt atcctatttc tggaggagtg 1680ggggtggtgg gtaggaatct caagagcgat ttgctcctct gcacaatagc ttctttaagg 1740acaccagggc ccccagggct atacatttcc ctgaagcttt ccagataagc aacaaggtat 1800gagcacctgc tatgtattgc ccaagggtga tgtgtttaaa tatccattgc atattttaaa 1860tccttggctg gcttaaagct gcaagctttc tgtcttcagt ggatataatg ggggcataca 1920tcccagagct tgcccaacac tccaagaaaa gaaccctcag ctaatgcaaa gtgtgtatgt 1980gcccatgaaa gctccatgtc tacttaacat tcagttttta ggattattta tgctgtaata 2040atagatatga aaatctctga caggtatttt gtttccttta caaactgtat ttgaatttat 2100gggtgattta gagcttgtgt ttaaagtcag aattcagaac cccaaagaaa atgacttcat 2160tgaaattgaa ctgaagagac aagaactgag ttaccaaaac ctactaaacg tgagttgctg 2220tgaactgggg attaaaccag aacgagtgga gaagatcaga aagctaccaa acacactgct 2280
cagaaaggac aaagacattc gaagactgcg ggactttcag gaagtggaac tcattttaat2340gaaaaatgga agctccagat tgacagaata tgtgccatct ctgacagaaa ggccctgcta2400tgatagcaaa gctgcaaaaa tgacttatta aatactccca ggaatggccg cgcatggtgg2460ctcaccccct gtaatcccag cactttggga agccaaggtg ggcggatcac ctgaggtcag2520gagttctaga ccagcctggc caacatatag tgaaacccag tctctactaa aaaaaataca2580aaaattagct aggtgtggtg gcgcacacct gtagtagtcc cagctacatg ggaagctgag2640gcaggagaat cacctgaacc caggaggcag aggttgcagt gagctgagat tgcgccactg2700cactccagcc tggcgacaga gcaagactct gtctctcaaa ataaataaat aaataaataa2760ataaataaat aaataatc 2778<210>35<211>2973<212>DNA<213>人<400>35attctggggc tcgggggatc ccggacaccc tctcagctcc tgcccggggg cccatgtagt 60cccttctgcc ctgtgcctcg gtgcctgtga cctgagcccc ttggttgacc ctgcactcgt120ccaacttggg ccaaacgact gcccctcctt ctggcagtgg gctggaccag ccggccagcg180ggagccccct tggcagaagc cggtcgtaaa ggatcataaa ctggcggcgt ctggctgggg240cgaaggtcgc tgaggtagga actgcgccag tcctagacgc cagacccgct cagaccctcc300tgccaggtga cagccgccaa gatggggtct tgggccctgc tgtggcctcc cctgctgttc360accgggctgc tcgtccgacc cccggggacc atggcccagg cccagtactg ctctgtgaac420aaggacatct ttgaagtaga ggagaacaca aatgtcaccg agccgctggt ggacatccac480gtcccggagg gccaggaggt gaccctcgga gccttgtcca ccccctttgc atttcggatc540cagggaaacc agctgtttct caacgtgact cctgattacg aggagaagtc actgcttgag600gctcagctgc tgtgtcagag cggaggcaca ttggtgaccc agctaagggt gttcgtgtca660gtgctggacg tcaatgacaa tgcccccgaa ttccccttta agaccaagga gataagggtg720gaggaggaca cgaaagtgaa ctccaccgtc atccccgaga cgcaactgca ggctgaggac780cgcgacaagg acgacattct gttctacacc ctccaggaaa tgacagcagg tgccagtgac840tacttctccc tggtgagtgt aaaccgtccc gccctgaggc tggaccggcc cctggacttc900tacgagcggc cgaacatgac cttctggctg ctggtgcggg acactccggg ggagaatgtg960
gaacccagcc acactgccac cgccacacta gtgctgaacg tggtgcccgc cgacctgcgg 1020cccccgtggt tcctgccctg caccttctca gatggctacg tctgcattca agctcagtac 1080cacggggctg tccccacggg gcacatactg ccatctcccc tcgtcctgcg tcccggaccc 1140atctacgctg aggacggaga ccgcggcatc aaccagccca tcatctacag catctttagg 1200ggaaacgtga atggtacatt catcatccac ccagactcgg gcaacctcac cgtggccagg 1260agtgtcccca gccccatgac cttccttctg ctggtgaagg gccaacaggc cgaccttgcc 1320cgctactcag tgacccaggt caccgtggag gctgtggctg cggccgggag cccgccccgc 1380ttcccccaga gcctgtatcg tggcaccgtg gcgcgtggcg ctggagcggg cgttgtggtc 1440aaggatgcag ctgccccttc tcagcctctg aggatccagg ctcaggaccc ggagttctcg 1500gacctcaact cggccatcac atatcgaatt accaaccact cacacttccg gatggaggga 1560gaggttgtgc tgaccaccac cacactggca caggcgggag ccttctacgc agaggttgag 1620gcccacaaca cggtgacctc tggcaccgca accacagtca ttgagataca agtttccgaa 1680caggagcccc cctccacaga tgtcccccca tccccagagg ctggaggaac aactgggccc 1740tggaccagca ccacttccga ggtccccaga ccccctgagc cctcccaggg accctccacg 1800accagctctg ggggaggcac aggccctcat ccaccctctg gcacaactct gaggccacca 1860acctcgtcca cacccggggg gtccccgggt gcagaaaaca gcacctccca ccaaccagcc 1920actcccggtg gggacacagc acagacccca aagccaggaa cctctcagcc gatgcccccc 1980ggtgtgggaa ccagcacctc ccaccaacca gccacaccca gtgggggcac agtacagacc 2040ccagagccag gaacctctca gccgatgccc cccagtatgg gaaccagcac ctcccaccaa 2100ccagccacac ccggtggggg cacagcacag accccagagg caggaacctc tcagccgatg 2160ccccccggta tgggaaccag cacctcccac caaccaacca cacccggtgg gggcacagca 2220cagaccccag agccaggaac ctctcagccg atgcccctca gcaagagcac cccatcttca 2280ggtggcggcc cctcggagga caagcgcttc tcggtggtgg atatggcggc cctgggcggg 2340gtgctgggtg cgctgctgct gctggctctc cttggcctcg ccgtccttgt ccacaagcac 2400tatggccccc ggctcaagtg ctgctctggc aaagctccgg agccccagcc ccaaggcttt 2460gacaaccagg cgttcctccc tgaccacaag gccaactggg cgcccgtccc cagccccacg 2520cacgacccca agcccgcgga ggcaccgatg cccgcagagc ccgcaccccc cggccctgcc 2580tccccaggcg gtgcccctga gccccccgca gcggcccgag ctggcggaag ccccacggcg 2640gtgaggtcca tcctgaccaa ggagcggcgg ccagagggcg ggtacaaggc tgtctggttt 2700
ggcgaggaca tcgggacgga ggcagacgtg gtcgttctca acgcgcccac cctggacgtg2760gatggcgcca gtgactccgg cagcggcgat gagggcgagg gcgcggggag gggtgggggt2820ccctacgatg cgcccggtgg tgatgactcc tacatctaag tggcccctcc accctctccc2880ccagccgcac gggcactgga ggtctcgctc ccccagcctc cgacccgagg cagaataaag2940caaggctccc gaaacccaaa aaaaaaaaaa aaa 2973<210>36<211>1930<212>DNA<213>人<400>36ggagagagag aggacagaga gcaagtcact cccggctgcc tttttcacct ctgacagagc 60ccagacacca tgaacgcaag tgaattccga aggagaggga aggagatggt ggattacgtg120gccaactaca tggaaggcat tgagggacgc caggtctacc ctgacgtgga gcccgggtac180ctgcggccgc tgatccctgc cgctgcccct caggagccag acacgtttga ggacatcatc240aacgacgttg agaagataat catgcctggg gtgacgcact ggcacagccc ctacttcttc300gcctacttcc ccactgccag ctcgtacccg gccatgcttg cggacatgct gtgcggggcc360attggctgca tcggcttctc ctgggcggca agcccagcat gcacagagct ggagactgtg420atgatggact ggctcgggaa gatgctggaa ctaccaaagg catttttgaa tgagaaagct480ggagaagggg gaggagtgat ccagggaagt gccagtgaag ccaccctggt ggccctgctg540gccgctcgga ccaaagtgat ccatcggctg caggcagcgt ccccagagct cacacaggcc600gctatcatgg agaagctggt ggcttactca tccgatcagg cacactcctc agtggaaaga660gctgggttaa ttggtggagt gaaattaaaa gccatcccct cagatggcaa cttcgccatg720cgtgcgtctg ccctgcagga agccctggag agagacaaag cggctggcct gattcctttc780tttatggttg ccaccctggg gaccacaaca tgctgctcct ttgacaatct cttagaagtc840ggtcctatct gcaacaagga agacatatgg ctgcacgttg atgcagccta cgcaggcagt900gcattcatct gccctgagtt ccggcacctt ctgaatggag tggagtttgc agattcattc960aactttaatc cccacaaatg gctattggtg aattttgact gttctgccat gtgggtgaaa 1020aagagaacag acttaacggg agcctttaga ctggacccca cttacctgaa gcacagccat 1080caggattcag ggcttatcac tgactaccgg cattggcaga taccactggg cagaagattt 1140cgctctttga aaatgtggtt tgtatttagg atgtatggag tcaaaggact gcaggcttat 1200
atccgcaagc atgtccagct gtcccatgag tttgagtcac tggtgcgcca ggatccccgc 1260tttgaaatct gtgtggaagt cattctgggg cttgtctgct ttcggctaaa gggttccaac 1320aaagtgaatg aagctcttct gcaaagaata aacagtgcca aaaaaatcca cttggttcca 1380tgtcacctca gggacaagtt tgtcctgcgc tttgccatct gttctcgcac ggtggaatct 1440gcccatgtgc agcgggcctg ggaacacatc aaagagctgg cggccgacgt gctgcgagca 1500gagagggagt aggagtgaag ccagctgcag gaatcaaaaa ttgaagagag atatatctga 1560aaactggaat aagaagcaaa taaatatcat cctgccttca tggaactcag ctgtctgtgg 1620cttcccatgt ctttctccaa agccatccag agggttgtga ttttgtctgc ttagtatctc 1680atcaacaaag aaatattatt tgctaattaa aaagttaatc ttcatggcca tagcttttat 1740tcattagctg tgatttttgt tgattaaaac attatagatt ttcatgttct tgcagtcatc 1800agaagtggta ggaaagcctc actgatatat tttccagggc aatcaatgtt cacgcaactt 1860gaaattatat ctgtggtctt caaattgtct tttgtcatgt ggctaaatgc ctaataaaca 1920attcaagtga 1930<210>37<211>1745<212>DNA<213>人<400>37gcgcccctgg cagccttcaa cgtcggtccc caggcagcat ggtgaggtct gctcccggac 60cctcgccacc atgtacgtga gctacctcct ggacaaggac gtgagcatgt accctagctc120cgtgcgccac tctggcggcc tcaacctggc gccgcagaac ttcgtcagcc ccccgcagta180cccggactac ggcggttacc acgtggcggc cgcagctgca gcgcagaact tggacagcgc240gcagtccccg gggccatcct ggccggcagc gtatggcgcc ccactccggg aggactggaa300tggctacgcg cccggaggcg cggccgccgc caacgccgtg gctcacgcgc tcaacggtgg360ctccccggcc gcagccatgg gctacagcag ccccgcagac taccatccgc accaccaccc420gcatcaccac ccgcaccacc cggccgccgc gccttcctgc gcttctgggc tgctgcaaac480gctcaacccc ggccctcctg ggcccgccgc caccgctgcc gccgagcagc tgtctcccgg540cggccagcgg cggaacctgt gcgagtggat gcggaagccg gcgcagcagt ccctcggcag600ccaagtgaaa accaggacga aagacaaata tcgagtggtg tacacggacc accagcggct660ggagctggag aaggagtttc actacagtcg ctacatcacc atccggagga aagccgagct720
agccgccacg ctggggctct ctgagaggca ggttaaaatc tggtttcaga accgcagagc780aaaggagagg aaaatcaaca agaagaagtt gcagcagcaa cagcagcagc agccaccaca840gccgcctccg ccgccaccac agcctcccca gcctcagcca ggtcctctga gaagtgtccc900agagcccttg agtccggtgt cttccctgca agcctcagtg tctggctctg tccctggggt960tctggggcca actggggggg tgctaaaccc caccgtcacc cagtgaccca ccggggtctg 1020cagcggcaga gcaattccag gctgagccat gaggagcgtg gactctgcta gactcctcag 1080gagagacccc tcccctccca cccacagcca tagacctaca gacctggctc tcagaggaaa 1140aatgggagcc aggagtaaga caagtgggat ttggggcctc aagaaatata ctctcccaga 1200tttttacttt ttccatctgg ctttttctgc cactgaggag acagaaagcc tccgctgggc 1260ttcattccgg actggcagaa gcattgcctg gactgaccac accaaccagc ttcatctatc 1320cgactcttct cttcctagat ctgcaggctg cacctctggc tagagccgag gggagagagg 1380gactcaaggg aaaggcaagc ttgaggccaa gatggctgct gcctgctcat ggccctcgga 1440ggtccagctg ggcctcctgc ctccgggcag caaggtttac actgcggaac gcaaaggcag 1500ctaagataga aagctggact gaccaaagac tgcagaaccc ccaggtggcc ctgcgtcttt 1560tttctcttcc ctttcccaga ccaggaaagg cttggctggt gtatgcacag ggtgtggtat 1620gagggggtgg ttattggact ccaggcctga ccagggggcc cgaacaggac ttgttagaga 1680gcctgtcacc agagcttctc tgggctgaat gtatgtcagt gctataaatg ccagagccaa 1740cctgg 1745<210>38<211>1881<212>DNA<213>人<400>38ggacctctcc agaatccgga ttgctgaatc ttccctgttg cctagaaggg ctccaaacca 60cctcttgaca atgggaaact gggtggttaa ccactggttt tcagttttgt ttctggttgt120ttggttaggg ctgaatgttt tcctgtttgt ggatgccttc ctgaaatatg agaaggccga180caaatactac tacacaagaa aaatccttgg gtcaacattg gcctgtgccc gagcgtctgc240tctctgcttg aattttaaca gcacgctgat cctgcttcct gtgtgtcgca atctgctgtc300cttcctgagg ggcacctgct cattttgcag ccgcacactg agaaagcaat tggatcacaa360cctcaccttc cacaagctgg tggcctatat gatctgccta catacagcta ttcacatcat420
tgcacacctg tttaactttg actgctatag cagaagccga caggccacag atggctccct480tgcctccatt ctctccagcc tatctcatga tgagaaaaag gggggttctt ggctaaatcc540catccagtcc cgaaacacga cagtggagta tgtgacattc accagcattg ctggtctcac600tggagtgatc atgacaatag ccttgattct catggtaact tcagctactg agttcatccg660gaggagttat tttgaagtct tctggtatac tcaccacctt tttatcttct atatccttgg720cttagggatt cacggcattg gtggaattgt ccggggtcaa acagaggaga gcatgaatga780gagtcatcct cgcaagtgtg cagagtcttt tgagatgtgg gatgatcgtg actcccactg840taggcgccct aagtttgaag ggcatccccc tgagtcttgg aagtggatcc ttgcaccggt900cattctttat atctgtgaaa ggatcctccg gttttaccgc tcccagcaga aggttgtgat960taccaaggtt gttatgcacc catccaaagt tttggaattg cagatgaaca agcgtggctt 1020cagcatggaa gtggggcagt atatctttgt taattgcccc tcaatctctc tcctggaatg 1080gcatcctttt actttgacct ctgctccaga ggaagatttc ttctccattc atatccgagc 1140agcaggggac tggacagaaa atctcataag ggctttcgaa caacaatatt caccaattcc 1200caggattgaa gtggatggtc cctttggcac agccagtgag gatgttttcc agtatgaagt 1260ggctgtgctg gttggagcag gaattggggt cacccccttt gcttctatct tgaaatccat 1320ctggtacaaa ttccagtgtg cagaccacaa cctcaaaaca aaaaagatct atttctactg 1380gatctgcagg gagacaggtg ccttttcctg gttcaacaac ctgttgactt ccctggaaca 1440ggagatggag gaattaggca aagtgggttt tctaaactac cgtctcttcc tcaccggatg 1500ggacagcaat attgttggtc atgcagcatt aaactttgac aaggccactg acatcgtgac 1560aggtctgaaa cagaaaacct cctttgggag accaatgtgg gacaatgagt tttctacaat 1620agctacctcc caccccaagt ctgtagtggg agttttctta tgtggccctc ggactttggc 1680aaagagcctg cgcaaatgct gtcaccgata ttccagtctg gatcctagaa aggttcaatt 1740ctacttcaac aaagaaaatt tttgagttat aggaataagg acggtaatct gcattttgtc 1800tctttgtatc ttcagtaatt tacttggtct cgtcaggttt gagcagtcac tttaggataa 1860gaatgtgcct ctcaagcctt g 1881<210>39<211>3745<212>DNA<213>人
<400>39cgcaaagcaa gtgggcacaa ggagtatggt tctaacgtga ttggggtcat gaagacgttg 60ctgttggact tggctttgtg gtcactgctc ttccagcccg ggtggctgtc ctttagttcc120caggtgagtc agaactgcca caatggcagc tatgaaatca gcgtcctgat gatgggcaac180tcagcctttg cagagcccct gaaaaacttg gaagatgcgg tgaatgaggg gctggaaata240gtgagaggac gtctgcaaaa tgctggccta aatgtgactg tgaacgctac tttcatgtat300tcggatggtc tgattcataa ctcaggcgac tgccggagta gcacctgtga aggcctcgac360ctactcagga aaatttcaaa tgcacaacgg atgggctgtg tcctcatagg gccctcatgt420acatactcca ccttccagat gtaccttgac acagaattga gctaccccat gatctcagct480ggaagttttg gattgtcatg tgactataaa gaaaccttaa ccaggctgat gtctccagct540agaaagttga tgtacttctt ggttaacttt tggaaaacca acgatctgcc cttcaaaact600tattcctgga gcacttcgta tgtttacaag aatggtacag aaactgagga ctgtttctgg660taccttaatg ctctggaggc tagcgtttcc tatttctccc acgaactcgg ctttaaggtg720gtgttaagac aagataagga gtttcaggat atcttaatgg accacaacag gaaaagcaat780gtgattatta tgtgtggtgg tccagagttc ctctacaagc tgaagggtga ccgagcagtg840gctgaagaca ttgtcattat tctagtggat cttttcaatg accagtactt ggaggacaat900gtcacagccc ctgactatat gaaaaatgtc cttgttctga cgctgtctcc tgggaattcc960cttctaaata gctctttctc caggaatcta tcaccaacaa aacgagactt tgctcttgcc 1020tatttgaatg gaatcctgct ctttggacat atgctgaaga tatttcttga aaatggagaa 1080aatattacca cccccaaatt tgctcatgct ttcaggaatc tcacttttga agggtatgac 1140ggtccagtga ccttggatga ctggggggat gttgacagta ccatggtgct tctgtatacc 1200tctgtggaca ccaagaaata caaggttctt ttgacctatg atacccacgt aaataagacc 1260tatcctgtgg atatgagccc cacattcact tggaagaact ctaaacttcc taatgatatt 1320acaggccggg gccctcagat cctgatgatt gcagtcttca ccctcactgg agctgtggtg 1380ctgctcctgc tcgtcgctct cctgatgctc agaaaatata gaaaagatta tgaacttcgt 1440cagaaaaaat ggtcccacat tcctcctgaa aatatctttc ctctggagac caatgagacc 1500aatcatgtta gcctcaagat cgatgatgac aaaagacgag atacaatcca gagactacga 1560cagtgcaaat acgacaaaaa gcgagtgatt ctcaaagatc tcaagcacaa tgatggtaat 1620ttcactgaaa aacagaagat agaattgaac aagttgcttc agattgacta ttacaacctg 1680
accaagttct acggcacagt gaaacttgat accatgatct tcggggtgat agaatactgt 1740gagagaggat ccctccggga agttttaaat gacacaattt cctaccctga tggcacattc 1800atggattggg agtttaagat ctctgtcttg tatgacattg ctaagggaat gtcatatctg 1860cactccagta agacagaagt ccatggtcgt ctgaaatcta ccaactgcgt agtggacagt 1920agaatggtgg tgaagatcac tgattttggc tgcaattcca ttttacctcc aaaaaaggac 1980ctgtggacag ctccagagca cctccgccaa gccaacatct ctcagaaagg agatgtgtac 2040agctatggga tcatcgcaca ggagatcatt ctgcggaaag aaaccttcta cactttgagc 2100tgtcgggacc ggaatgagaa gattttcaga gtggaaaatt ccaatggaat gaaacccttc 2160cgcccagatt tattcttgga aacagcagag gaaaaagagc tagaagtgta cctacttgta 2220aaaaactgtt gggaggaaga tccagaaaag agaccagatt tcaaaaaaat tgagactaca 2280cttgccaaga tatttggact ttttcatgac caaaaaaatg aaagctatat ggataccttg 2340atccgacgtc tacagctata ttctcgaaac ctggaacatc tggtagagga aaggacacag 2400ctgtacaagg cagagaggga cagggctgac agacttaact ttatgttgct tccaaggcta 2460gtggtaaagt ctctgaagga gaaaggcttt gtggagccgg aactatatga ggaagttaca 2520atctacttca gtgacattgt aggtttcact actatctgca aatacagcac ccccatggaa 2580gtggtggaca tgcttaatga catctataag agttttgacc acattgttga tcatcatgat 2640gtctacaagg tggaaaccat cggtgatgcg tacatggtgg ctagtggttt gcctaagaga 2700aatggcaatc ggcatgcaat agacattgcc aagatggcct tggaaatcct cagcttcatg 2760gggacctttg agctggagca tcttcctggc ctcccaatat ggattcgcat tggagttcac 2820tctggtccct gtgctgctgg agttgtggga atcaagatgc ctcgttattg tctatttgga 2880gatacggtca acacagcctc taggatggaa tccactggcc tccctttgag aattcacgtg 2940agtggctcca ccatagccat cctgaagaga actgagtgcc agttccttta tgaagtgaga 3000ggagaaacat acttaaaggg aagaggaaat gagactacct actggctgac tgggatgaag 3060gaccagaaat tcaacctgcc aacccctcct actgtggaga atcaacagcg tttgcaagca 3120gaattttcag acatgattgc caactcttta cagaaaagac aggcagcagg gataagaagc 3180caaaaaccca gacgggtagc cagctataaa aaaggcactc tggaatactt gcagctgaat 3240accacagaca aggagagcac ctatttttaa acctaaatga ggtataagga ctcacacaaa 3300ttaaaataca gctgcactga ggcagcgacc tcaagtgtcc tgaaagctta cattttcctg 3360agacctcaat gaagcagaaa tgtacttagg cttggctgcc ctgtctggaa catggacttt 3420
cttgcatgaa tcagatgtgt gttctcagtg aaataactac cttccactct ggaaccttat 3480tccagcagtt gttccaggga gcttctacct ggaaaagaaa agaaatgaat agactatcta 3540gaacttgaga agattttatt cttatttcat ttattttttg tttgtttatt tttatcgttt 3600ttgtttactg gctttccttc tgtattcata agatttttta aattgtcata attatatttt 3660aaatacccat cttcattaaa gtatatttaa ctcataattt ttgcagaaaa tatgctatat 3720attaggcaag aataaaagct aaagg 3745<210>40<211>2793<212>DNA<213>人<400>40ctaccccttt gtgagcagtc taggactttg tacacctgtt aagtagggag aaggcagggg 60aggtggctgg tttaagggga acttgaggga agtagggaag actcctcttg ggacctttgg120agtaggtgac acatgagccc agccccagct cacctgccaa tccagctgag gagctcacct180gccaatccag ctgaggctgg gcagaggtgg gtgagaagag ggaaaattgc agggacctcc240agttgggcca ggccagaagc tgctgtagct ttaaccagac agctcagacc tgtctggagg300ctgccagtga caggttaggt ttagggcaga gaagaagcaa gaccatggtg gggaagatgt360ggcctgtgtt gtggacactc tgtgcagtca gggtgaccgt cgatgccatc tctgtggaaa420ctccgcagga cgttcttcgg gcttcgcagg gaaagagtgt caccctgccc tgcacctacc480acacttccac ctccagtcga gagggactta ttcaatggga taagctcctc ctcactcata540cggaaagggt ggtcatctgg ccgttttcaa acaaaaacta catccatggt gagctttata600agaatcgcgt cagcatatcc aacaatgctg agcagtccga tgcctccatc accattgatc660agctgaccat ggctgacaac ggcacctacg agtgttctgt ctcgctgatg tcagacctgg720agggcaacac caagtcacgt gtccgcctgt tggtcctcgt gccaccctcc aaaccagaat780gcggcatcga gggagagacc ataattggga acaacatcca gctgacctgc caatcaaagg840agggctcacc aacccctcag tacagctgga agaggtacaa catcctgaat caggagcagc900ccctggccca gccagcctca ggtcagcctg tctccctgaa gaatatctcc acagacacat960cgggttacta catctgtacc tccagcaatg aggaggggac gcagttctgc aacatcacgg 1020tggccgtcag atctccctcc atgaacgtgg ccctgtatgt gggcatcgcg gtgggcgtgg 1080ttgcagccct cattatcatt ggcatcatca tctactgctg ctgctgccga gggaaggacg 1140
acaacactga agacaaggag gatgcaaggc cgaaccggga agcctatgag gagccaccag 1200agcagctaag agaactttcc agagagaggg aggaggagga tgactacagg caagaagagc 1260agaggagcac tgggcgtgaa tccccggacc acctcgacca gtgacaggcc agcagcagag 1320ggcggcggag gaagggttag gggttcattc tcccgcttcc tggcctccct tctcctttct 1380aagccctgtt ctcctgtccc tccatcccag acattgatgg ggacatttct tccccagtgt 1440cagctgtggg gaacatggct ggcctggtaa gggggtccct gtgctgatcc tgctgacctc 1500actgtcctgt gaagtaaccc ctcctggctg tgacacctgg tgcgggcctg gccctcactc 1560aagaccaggc tgcagcctcc acttccctcg tagttggcag gagctcctgg aagcacagcg 1620ctgagcatgg ggcgctccca ctcagaactc tccagggagg cgatgccagc cttggggggt 1680gggggctgtc ctgctcacct gtgtgcccag cacctggagg ggcaccaggt ggagggtttg 1740cactccacac atctttcttg aatgaatgaa agaataagtg agtatgcttg ggccctgcat 1800tggcctggcc tccagctccc actccctttc caacctcact tcccgtagct gccagtatgt 1860tccaaaccct cctgggaagg ccacctccca ctcctgctgc acaggccctg gggagctttt 1920gcccacacac tttccatctc tgcctgtcaa tatcgtacct gtccctccag gcccatctca 1980aatcacaagg atttctctaa ccctatccta attgtccaca tacgtggaaa caatcctgtt 2040actctgtccc acgtccaatc atgggccaca aggcacagtc ttctgagcga gtgctctcac 2100tgtattagag cgccagctcc ttggggcagg gcctgggcct catggctttt gctttccctg 2160aagccctagt agctggcgcc catcctagtg ggcacttaag cttaattggg gaaactgctt 2220tgattggttg tgccttccct tctctggtct ccttgagatg atcgtagaca cagggatgat 2280tcccacccaa acccacgtat tcattcagtg agttaaacac gaattgattt aaagtgaaca 2340cacacaaggg agcttgcttg cagatggtct gagttcttgt gtcctggtaa ttcctctcca 2400ggccagaata attggcatgt ctcctcaacc cacatggggt tcctggttgt tcctgcatcc 2460cgatacctca gccctggccc tgcccagccc atttgggctc tggttttctg gtggggctgt 2520cctgctgccc tcccacagcc tccttctgtt tgtcgagcat ttcttctact cttgagagct 2580caggcagcgt tagggctgct taggtctcat ggaccagtgg ctggtctcac ccaactgcag 2640tttactattg ctatcttttc tggatgatca gaaaaataat tccataaatc tattgtctac 2700ttgcgatttt ttaaaaaatg tatattttta tatatattgt taaatccttt gcttcattcc 2760aaatgctttc agtaataata aaattgtggg tgg2793
<210>41<211>1734<212>DNA<213>人<400>41ggacctctcc agaatccgga ttgctgaatc ttccctgttg cctagaaggg ctccaaacca 60cctcttgaca atgggaaact gggtggttaa ccactggttt tcagttttgt ttctggttgt120ttggttaggg ctgaatgttt tcctgtttgt ggatgccttc ctgaaatatg agaaggccga180caaatactac tacacaagaa aaatccttgg gtcaacattg gcctgtgccc gagcgtctgc240tctctgcttg aattttaaca gcacgctgat cctgcttcct gtgtgtcgca atctgctgtc300cttcctgagg ggcacctgct cattttgcag ccgcacactg agaaagcaat tggatcacaa360cctcaccttc cacaagctgg tggcctatat gatctgccta catacagcta ttcacatcat420tgcacacctg tttaactttg actgctatag cagaagccga caggccacag atggctccct480tgcctccatt ctctccagcc tatctcatga tgagaaaaag gggggttctt ggctaaatcc540catccagtcc cgaaacacga cagtggagta tgtgacattc accagcattg ctggtctcac600tggagtgatc atgacaatag ccttgattct catggtaact tcagctactg agttcatccg660gaggagttat tttgaagtct tctggtatac tcaccacctt tttatcttct atatccttgg720cttagggatt cacggcattg gtggaattgt ccggggtcaa acagaggaga gcatgaatga780gagtcatcct cgcaagtgtg cagagtcttt tgagatgtgg gatgatcgtg actcccactg840taggcgccct aagtttgaag ggcatccccc tgagtcttgg aagtggatcc ttgcaccggt900cattctttat atctgtgaaa ggatcctccg gttttaccgc tcccagcaga aggttgtgat960taccaaggtt gttatgcacc catccaaagt tttggaattg cagatgaaca agcgtggctt 1020cagcatggaa gtggggcagt atatctttgt taattgcccc tcaatctctc tcctggaatg 1080gcatcctttt actttgacct ctgctccaga ggaagatttc ttctccattc atatccgagc 1140agcaggggac tggacagaaa atctcataag ggctttcgaa caacaatatt caccaattcc 1200caggattgaa gtggatggtc cctttggcac agccagtgag gatgttttcc agtatgaagt 1260ggctgtgctg gttggagcag gaattggggt cacccccttt gcttctatct tgaaatccat 1320ctggtacaaa ttccagtgtg cagaccacaa cctcaaaaca aaaaaggttg gtcatgcagc 1380attaaacttt gacaaggcca ctgacatcgt gacaggtctg aaacagaaaa cctcctttgg 1440gagaccaatg tgggacaatg agttttctac aatagctacc tcccacccca agtctgtagt 1500
gggagttttc ttatgtggcc ctcggacttt ggcaaagagc ctgcgcaaat gctgtcaccg 1560atattccagt ctggatccta gaaaggttca attctacttc aacaaagaaa atttttgagt 1620tataggaata aggacggtaa tctgcatttt gtctctttgt atcttcagta atttacttgg 1680tctcgtcagg tttgagcagt cactttagga taagaatgtg cctctcaagc cttg 1734<210>42<211>3941<212>DNA<213>人<400>42accatctact ccacagtcag ctcatccaca actgccatca cctcaccttt cactaccgca 60gagactgggg tgacttccac accttcatcc ccatcttctc tgagtacaga catcccgacc120acatccctaa gaactctcac cccattatct ttgagcacca gcacttcatt gactacaacc180acagaccttc cctctatacc cactgatatc agtagcttac caaccccaat acacatcatt240tcatcttctc cctccatcca aagtacagaa acctcatccc ttgtgggcac cacctctccc300accatgtcca ctgtgagagc gaccctcaga agtactgaga acaccccaat cagttccttt360agcacaagta ttgttgttac acctgaaacc ccaacaacac aggcccctcc tgtactgatg420tctgccactg ggacccaaac atcccctgta cctactactg tcacctttgg aagtatggat480tcctctacgt ccactcttca tactcttact ccatcaacag ccttgagcaa gatcatgtca540acatcacagt ttcctattcc tagcacacat tcctccaccc ttcaaacaac tccttcaatc600ccctctttgc aaacttcact cacatctaca agtgagttca ctacagaatc tttcactagg660ggaagtacgt ctacaaatgc aatcttgact tcttttagta ccatcatctg gtcctcaaca720cccactatta tcatgtcctc ttctccatct tctgccagca taactccagt gttcgctact780accattcatt ctgttccttc gtcaccatac attttcagta cagaaaatgt gggctccgct840tctatcacag cctttcctag tctctcttcc tcttcaacta ccagcacttc tccaaccagc900tcctctctga ccacagctct cactgaaata accccctttt cttatatttc ccttccctcc960accacaccct gtccaggaac tataacaatt accatagtcc ctgcctcccc cactgatcca 1020tgtgttgaaa tggatcccag cactgaagct acttctcctc ccaccactcc attaacagtc 1080tttcccttta ctactgaaat ggtcacctgt cctagctcca tcagtatgca aactactctt 1140gctacacata tggacacttc ttccatgacg ccagaaagtg agtccagcat catacctaat 1200gcttccagtt ccactggcac tgggactgta cccacaaaca cagttttcac aagtactcga 1260
ctgcccacca gtgagacctg gctgagcaac aactctgtga tccccacacc tcttcctggc 1320gtctctacca tcccgctcac catgaaacca agcagtagcc tcccgaccat cctgaggact 1380tcaagcaagt caacacaccc atccccaccc accgccagga cttcagagac atcagtggcc 1440actacccaga ctcctaccac ccttacaacg cgcaggacaa ctcccatcac ttcttggatg 1500accacacagt ccacgttgac caccactgca ggcacctgtg acaatggtgg cacctgggaa 1560cagggccagt gtgcttgcct tccggggttt tctggggacc gctgtcagct ccagaccaga 1620tgccagaacg ggggccagtg ggatggcctc aagtgccagt gccccagcac cttctatggt 1680tccagttgtg agtttgctgt ggaacaggtg gatctagatg tagtggagac cgaggtgggc 1740atggaagtgt ctgtggatca gcagttctcg ccggacctca atgacaacac ttcccaggcc 1800tacagggatt tcaacaagac cttctggaat cagatgcaga agatttttgc agacatgcag 1860ggcttcacct tcaagggtgt ggagatcctg tccctgagga atggcagcat cgtggtggac 1920tacctggtcc tgctggagat gcccttcagc ccccagctgg agagcgagta tgagcaggtg 1980aagaccacgc tgaaggaggg gctccagaac gccagccagg atgcgaacag ctgccaggac 2040tcccagaccc tgtgttttaa gcctgactcc atcaaggtga acaacaacag caagacagag 2100ctgaccccgg aagccatctg ccgccgcgcc gctcccacgg gctatgaaga gttctacttc 2160cctctggtgg aggccacccg gctccgctgt gtcaccaaat gcacgtcggg cgtggacaac 2220gccatcgact gtcaccaggg ccagtgcgtt ctagagacga gcggtcccgc gtgtcgctgc 2280tactccaccg acacgcactg gttctctggc ccgcgctgcg aggtggccgt ccactggagg 2340gcgctggtcg ggggcctgac ggccggcgcc gcgctgctgg tgctgctgct gctggcgctg 2400ggcgtccggg cggtgcgctc cggatggtgg ggcggccagc gccgaggccg gtcctgggac 2460caggacagga aatggttcga gacctgggat gaggaagtcg tgggcacttt ttcaaactgg 2520ggtttcgagg acgacggaac agacaaggat acaaatttcc atgtggcctt ggagaacgtg 2580gacaccacta tgaaggtgca catcaagaga cccgagatga cctcgtcctc agtgtgagcc 2640ctgcggggcc ccttcaccac cccctccgcc ctgccccgga cacaagggtc tgcattgcgt 2700ccatttcaag aggtggcccc aggacgcggg cagcccaggc tcctgctgtt cttgggcaag 2760atgagactgt tcccccaaat cccatccttc tccttccaac ttggctgaaa cccacctgga 2820gacgcagttc acgtccaggc tcttccactg tggaatcttg ggcaagtcag taacgagcct 2880cagtttcctc acctgcaaaa cgggtacagc attcctgtat gatagctcac gccgttgttg 2940tgaaaaccac atagacttgg tcaattctcg gtcctactct gccctcccgt ctcagccctc 3000
gtgttgccat tgcctctctc ggatcctcca atcctcacgt ccttcacctg gtctctggcc 3060ctggttctta ttttctctca attccctact gcctgtttct tactttgaac ctggaggcag 3120cctgcagccc catcccatct cctgccctct cctgatctaa ctccctgctg catctcttgc 3180tctcattcct tagacgtcct ccccttttga ccccgttcct tcatccatcc tgcaccccag 3240tcccccagcc ctaaatcctc cctcctctcc tcacatcctg gtccctagca aggtatagat 3300agcctctgtg tcttaggata ccccgggtgc tgttccctcg gtcaccctgt tgcccagttc 3360cccgtttctc ttgctctcat tccttgtatc ttctcccctt ctgagcccgt ccattcatcg 3420gttctgcccc cgactccccc agccctaaat accccagctc ctaattcccc cctcaccccg 3480ttgctcaatt ccccgtttct cttgctctca ttccttgtat cttctcccct tctgagcctg 3540tccattcatc ggtggttctg cccctactcc cccagcccta aataccccag ctgctgttcc 3600tccccatcac ccagccaccg gattctccat tcaccccttt ctctcacccc tggagccccg 3660tgggtggggg cagggcatga gttccccagt ccccaaggaa aggcagcccc ctcagtctcc 3720ctcctcctca ttcccttcca tctccctccc ctctgccttt taaacccatc ccctccgatt 3780cccctcctcc cccctctctc cctggtgtca actcgattcc tgcggtaact ctgagccctg 3840aaatcctcag tctccttggc ggggaagatt ggctttgggg acaggaagtc ggcacatctc 3900caggtctcca tgtgcacaat atagagttta ttgtaaaaag c 3941<210>43<211>1126<212>DNA<213>人<400>43cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 60tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt120gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg180acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata240gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac300cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac360cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc420atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc480atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc540
ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca600gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat660ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag720acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc780accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc840agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc900cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac960ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1020ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1080gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg 1126<210>44<211>6129<212>DNA<213>人<400>44aattggaagc aaatgacatc acagcaggtc agagaaaaag ggttgagcgg caggcaccca 60gagtagtagg tctttggcat taggagcttg agcccagacg gccctagcag ggaccccagc120gcccgagaga ccatgcagag gtcgcctctg gaaaaggcca gcgttgtctc caaacttttt180ttcagctgga ccagaccaat tttgaggaaa ggatacagac agcgcctgga attgtcagac240atataccaaa tcccttctgt tgattctgct gacaatctat ctgaaaaatt ggaaagagaa300tgggatagag agctggcttc aaagaaaaat cctaaactca ttaatgccct tcggcgatgt360tttttctgga gatttatgtt ctatggaatc tttttatatt taggggaagt caccaaagca420gtacagcctc tcttactggg aagaatcata gcttcctatg acccggataa caaggaggaa480cgctctatcg cgatttatct aggcataggc ttatgccttc tctttattgt gaggacactg540ctcctacacc cagccatttt tggccttcat cacattggaa tgcagatgag aatagctatg600tttagtttga tttataagaa gactttaaag ctgtcaagcc gtgttctaga taaaataagt660attggacaac ttgttagtct cctttccaac aacctgaaca aatttgatga aggacttgca720ttggcacatt tcgtgtggat cgctcctttg caagtggcac tcctcatggg gctaatctgg780gagttgttac aggcgtctgc cttctgtgga cttggtttcc tgatagtcct tgcccttttt840caggctgggc tagggagaat gatgatgaag tacagagatc agagagctgg gaagatcagt900
gaaagacttg tgattacctc agaaatgatt gaaaatatcc aatctgttaa ggcatactgc960tgggaagaag caatggaaaa aatgattgaa aacttaagac aaacagaact gaaactgact 1020cggaaggcag cctatgtgag atacttcaat agctcagcct tcttcttctc agggttcttt 1080gtggtgtttt tatctgtgct tccctatgca ctaatcaaag gaatcatcct ccggaaaata 1140ttcaccacca tctcattctg cattgttctg cgcatggcgg tcactcggca atttccctgg 1200gctgtacaaa catggtatga ctctcttgga gcaataaaca aaatacagga tttcttacaa 1260aagcaagaat ataagacatt ggaatataac ttaacgacta cagaagtagt gatggagaat 1320gtaacagcct tctgggagga gggatttggg gaattatttg agaaagcaaa acaaaacaat 1380aacaatagaa aaacttctaa tggtgatgac agcctcttct tcagtaattt ctcacttctt 1440ggtactcctg tcctgaaaga tattaatttc aagatagaaa gaggacagtt gttggcggtt 1500gctggatcca ctggagcagg caagacttca cttctaatga tgattatggg agaactggag 1560ccttcagagg gtaaaattaa gcacagtgga agaatttcat tctgttctca gttttcctgg 1620attatgcctg gcaccattaa agaaaatatc atctttggtg tttcctatga tgaatataga 1680tacagaagcg tcatcaaagc atgccaacta gaagaggaca tctccaagtt tgcagagaaa 1740gacaatatag ttcttggaga aggtggaatc acactgagtg gaggtcaacg agcaagaatt 1800tctttagcaa gagcagtata caaagatgct gatttgtatt tattagactc tccttttgga 1860tacctagatg ttttaacaga aaaagaaata tttgaaagct gtgtctgtaa actgatggct 1920aacaaaacta ggattttggt cacttctaaa atggaacatt taaagaaagc tgacaaaata 1980ttaattttga atgaaggtag cagctatttt tatgggacat tttcagaact ccaaaatcta 2040cagccagact ttagctcaaa actcatggga tgtgattctt tcgaccaatt tagtgcagaa 2100agaagaaatt caatcctaac tgagacctta caccgtttct cattagaagg agatgctcct 2160gtctcctgga cagaaacaaa aaaacaatct tttaaacaga ctggagagtt tggggaaaaa 2220aggaagaatt ctattctcaa tccaatcaac tctatacgaa aattttccat tgtgcaaaag 2280actcccttac aaatgaatgg catcgaagag gattctgatg agcctttaga gagaaggctg 2340tccttagtac cagattctga gcagggagag gcgatactgc ctcgcatcag cgtgatcagc 2400actggcccca cgcttcaggc acgaaggagg cagtctgtcc tgaacctgat gacacactca 2460gttaaccaag gtcagaacat tcaccgaaag acaacagcat ccacacgaaa agtgtcactg 2520gcccctcagg caaacttgac tgaactggat atatattcaa gaaggttatc tcaagaaact 2580
ggcttggaaa taagtgaaga aattaacgaa gaagacttaa aggagtgcct ttttgatgat 2640atggagagca taccagcagt gactacatgg aacacatacc ttcgatatat tactgtccac 2700aagagcttaa tttttgtgct aatttggtgc ttagtaattt ttctggcaga ggtggctgct 2760tctttggttg tgctgtggct ccttggaaac actcctcttc aagacaaagg gaatagtact 2820catagtagaa ataacagcta tgcagtgatt atcaccagca ccagttcgta ttatgtgttt 2880tacatttacg tgggagtagc cgacactttg cttgctatgg gattcttcag aggtctacca 2940ctggtgcata ctctaatcac agtgtcgaaa attttacacc acaaaatgtt acattctgtt 3000cttcaagcac ctatgtcaac cctcaacacg ttgaaagcag gtgggattct taatagattc 3060tccaaagata tagcaatttt ggatgacctt ctgcctctta ccatatttga cttcatccag 3120ttgttattaa ttgtgattgg agctatagca gttgtcgcag ttttacaacc ctacatcttt 3180gttgcaacag tgccagtgat agtggctttt attatgttga gagcatattt cctccaaacc 3240tcacagcaac tcaaacaact ggaatctgaa ggcaggagtc caattttcac tcatcttgtt 3300acaagcttaa aaggactatg gacacttcgt gccttcggac ggcagcctta ctttgaaact 3360ctgttccaca aagctctgaa tttacatact gccaactggt tcttgtacct gtcaacactg 3420cgctggttcc aaatgagaat agaaatgatt tttgtcatct tcttcattgc tgttaccttc 3480atttccattt taacaacagg agaaggagaa ggaagagttg gtattatcct gactttagcc 3540atgaatatca tgagtacatt gcagtgggct gtaaactcca gcatagatgt ggatagcttg 3600atgcgatctg tgagccgagt ctttaagttc attgacatgc caacagaagg taaacctacc 3660aagtcaacca aaccatacaa gaatggccaa ctctcgaaag ttatgattat tgagaattca 3720cacgtgaaga aagatgacat ctggccctca gggggccaaa tgactgtcaa agatctcaca 3780gcaaaataca cagaaggtgg aaatgccata ttagagaaca tttccttctc aataagtcct 3840ggccagaggg tgggcctctt gggaagaact ggatcaggga agagtacttt gttatcagct 3900tttttgagac tactgaacac tgaaggagaa atccagatcg atggtgtgtc ttgggattca 3960ataactttgc aacagtggag gaaagccttt ggagtgatac cacagaaagt atttattttt 4020tctggaacat ttagaaaaaa cttggatccc tatgaacagt ggagtgatca agaaatatgg 4080aaagttgcag atgaggttgg gctcagatct gtgatagaac agtttcctgg gaagcttgac 4140tttgtccttg tggatggggg ctgtgtccta agccatggcc acaagcagtt gatgtgcttg 4200gctagatctg ttctcagtaa ggcgaagatc ttgctgcttg atgaacccag tgctcatttg 4260gatccagtaa cataccaaat aattagaaga actctaaaac aagcatttgc tgattgcaca 4320
gtaattctct gtgaacacag gatagaagca atgctggaat gccaacaatt tttggtcata 4380gaagagaaca aagtgcggca gtacgattcc atccagaaac tgctgaacga gaggagcctc 4440ttccggcaag ccatcagccc ctccgacagg gtgaagctct ttccccaccg gaactcaagc 4500aagtgcaagt ctaagcccca gattgctgct ctgaaagagg agacagaaga agaggtgcaa 4560gatacaaggc tttagagagc agcataaatg ttgacatggg acatttgctc atggaattgg 4620agctcgtggg acagtcacct catggaattg gagctcgtgg aacagttacc tctgcctcag 4680aaaacaagga tgaattaagt ttttttttaa aaaagaaaca tttggtaagg ggaattgagg 4740acactgatat gggtcttgat aaatggcttc ctggcaatag tcaaattgtg tgaaaggtac 4800ttcaaatcct tgaagattta ccacttgtgt tttgcaagcc agattttcct gaaaaccctt 4860gccatgtgct agtaattgga aaggcagctc taaatgtcaa tcagcctagt tgatcagctt 4920attgtctagt gaaactcgtt aatttgtagt gttggagaag aactgaaatc atacttctta 4980gggttatgat taagtaatga taactggaaa cttcagcggt ttatataagc ttgtattcct 5040ttttctctcc tctccccatg atgtttagaa acacaactat attgtttgct aagcattcca 5100actatctcat ttccaagcaa gtattagaat accacaggaa ccacaagact gcacatcaaa 5160atatgcccca ttcaacatct agtgagcagt caggaaagag aacttccaga tcctggaaat 5220cagggttagt attgtccagg tctaccaaaa atctcaatat ttcagataat cacaatacat 5280cccttacctg ggaaagggct gttataatct ttcacagggg acaggatggt tcccttgatg 5340aagaagttga tatgcctttt cccaactcca gaaagtgaca agctcacaga cctttgaact 5400agagtttagc tggaaaagta tgttagtgca aattgtcaca ggacagccct tctttccaca 5460gaagctccag gtagagggtg tgtaagtaga taggccatgg gcactgtggg tagacacaca 5520tgaagtccaa gcatttagat gtataggttg atggtggtat gttttcaggc tagatgtatg 5580tacttcatgc tgtctacact aagagagaat gagagacaca ctgaagaagc accaatcatg 5640aattagtttt atatgcttct gttttataat tttgtgaagc aaaatttttt ctctaggaaa 5700tatttatttt aataatgttt caaacatata ttacaatgct gtattttaaa agaatgatta 5760tgaattacat ttgtataaaa taatttttat atttgaaata ttgacttttt atggcactag 5820tatttttatg aaatattatg ttaaaactgg gacaggggag aacctagggt gatattaacc 5880aggggccatg aatcaccttt tggtctggag ggaagccttg gggctgatcg agttgttgcc 5940cacagctgta tgattcccag ccagacacag cctcttagat gcagttctga agaagatggt 6000
accaccagtc tgactgtttc catcaagggt acactgcctt ctcaactcca aactgactct 6060taagaagact gcattatatt tattactgta agaaaatatc acttgtcaat aaaatccata 6120catttgtgt 6129<210>45<211>330<212>DNA<213>人<400>45gcggccgcag gtacccgggc tccacgtcag ggtagacctg gcgtccctca atgccttcca 60tgtagttggc cacgtaatcc accatctcct tccctctcct tcggaattca cttgcgttca120tggtgtctgg gctctgtcag aggtgaaaaa tgctggaaat tcgaattcct tacagggcta180ctctccttga tgggattctc caactttggg gactgaagag catgtggaga agctgctgag240gcactcggca ctgagacagt cactcttctt gaaactccaa gccacacgtt tccctcttct300tgcatttcca gccacatgtg cccctcgtgc 330<210>46<211>2400<212>DNA<213>人<400>46ctgtagggga ggatattttg attgaacaca ggcttgacag aatcttcttt tcttcttaga 60aatcctagaa aacagaaagc aacaggaaga tgtcttattg ggaactaccc ccatcaactt120caccatgagt caaacaagga agaaaacttc ctcagaagga gaaactaagc cccagacttc180aactgtcaac aaatttctca ggggctccaa tgctgaaagc agaaaagagg acaatgacct240taaaacaagt gattcccaac ccagcgactg gatacagaag acagccacct cagagactgc300taagcctctc agttcagaaa tggaatggag atccagtatg gagaaaaatg agcatttcct360gcagaagctg ggcaaaaagg ctgtcaacaa gtgtctagat ttgaataact gtggattaac420aacagcggac atgaaagaaa tgggagaagc atttgagatg attcctgaac ttgaagagct480aaatttgtct tggaacagta aagtgggagg aaatttgcct ctgatccttc agaagttcca540aaaagggagc aagatacaaa tgattgagct tgtggattgc tccctcacgt cagaagatgg600gacatttctg ggtcaactgc tacctatgct gcaaagtctc gaagtacttg atctttccat660taacagagac attgttggca gtctgaacag tattgctcag ggattaaaaa gcacctcaaa720tctgaaagta ctgaagttac attcatgtgg attatcacaa aagagtgtca aaatattgga780
tgctgctttt aggtatttgg gtgagctgag gaaattagat ctttcctgca ataaggatct840aggtggaggt tttgaagact cgccggctca gttggtcatg ctaaagcatc tacaagtcct900agatcttcac cagtgctcac taacagcaga tgacgtgatg tcactgaccc aggtcattcc960tttactttca aatcttcaag aattggattt atcagccaac aaaaagatgg gcagttcttc 1020tgaaaactta ctcagcaggc tccgattttt accagcattg aagtcattag ttatcaacaa 1080ctgtgctttg gagagtgaga cttttacagc tcttgctgaa gcctctgttc acctctctgc 1140tctggaagta ttcaaccttt cttggaacaa gtgtgttggt ggcaacttgg agctgcttct 1200ggaaacacta aagctttcca tgtctcttca agtgctgagg ctgagcagct gttccctggt 1260gacagaggat gtggctctcc tggcatcggt catacagacg ggtcatctgg ccaaactgca 1320aaagctggac ctgagctaca atgacagcat ctgtgatgca gggtggacca tgttctgcca 1380aaacgtgcgg ttcctcaaag agctaatcga gctggatatt agccttcgac catcaaattt 1440tcgagattgt ggacaatggt ttagacactt gttatatgct gtgaccaagc ttcctcagat 1500cactgagata ggaatgaaaa gatggattct cccagcttca caggaggaag aactagaatg 1560ctttgaccaa gaaaaaaaaa agaagcattc actttgacca tggtgggttt cagtaaactg 1620atttcccatg tcctactaag ctacaaacca ttctccaaag gaaaagaaca tgaacgaatt 1680ccagagtcat gaactgaatt tcaacttctg ggccatttaa tgggacttat attacaagag 1740ctttgtaaat atatatatat attacatata tatatgtaat atacatatat acacatatat 1800ataatataca tatataatac acatatatat gtaaatatat atataatatc taatatgagc 1860atgccattat tctctgtcta tgaaacaaaa atggcatttt tcaatggatt tgttttggat 1920atataattag ttcatttgct gtttagaagc cttgccaaaa gtgtttagat tttggtactg 1980caactgcttt cctcttgccc agaaatgttt tgcctcttct tttcctacaa gttaaatgtt 2040ctaaatataa aggggtatgt gtgtgtgtgt gtaattctaa tgtgaaaggc actagctgtc 2100taatagtttc atgtatcatt actattacta tatgtatctt aatgtagtct atgtaggttt 2160ttatcagaaa gtgtaccttt ctatggttta ttattttata ttctggtgcc ttttatctca 2220gatataaacc atgaacagta atgatagtca ctgacatata aatcttagta aaaagtgatt 2280aaaaatctaa aactcagtat gaaaaacata tcttgttaga ataaattaaa accttttatt 2340gtttaaaaaa ttgttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2400<210>47
<211>2308<212>DNA<213>人<400>47aagccacttt gacaacgttt ctgagccagg ggtgaccatg acctgctgcg aaggatggac 60atcctgcaat ggattcagcc tgctggttct actgctgtta ggagtagttc tcaatgtgat120acctctaatt gtcagcttag ttgaggaaga ccaattttct caaaacccca tctcttgctt180tgagtggtgg ttcccaggaa ttataggagc aggtctgatg gccattccag caacaacaat240gtccttgaca gcaagaaaaa gagcgtgctg caacaacaga actggaatgt ttctttcatc300acttttcagt gtgatcacag tcattggtgc tctgtattgc atgctgatat ccatccaggc360tctcttaaaa ggtcctctca tgtgtaattc tccaagcaac agtaatgcca attgtgaatt420ttcattgaaa aacatcagtg acattcatcc agaatccttc aacttgcagt ggtttttcaa480tgactcttgt gcacctccta ctggtttcaa taaacccacc agtaacgaca ccatggcgag540tggctggaga gcatctagtt tccacttcga ttctgaagaa aacaaacata ggcttatcca600cttctcagta tttttaggtc tattgcttgt tggaattctg gaggtcctgt ttgggctcag660tcagatagtc atcggtttcc ttggctgtct gtgtggagtc tctaagcgaa gaagtcaaat720tgtgtagttt aatgggaata aaatgtaagt atcagtagtt tgaattaatt tgagaagtac780acttgttttc aaagtcatct ttgagatgat ttaaaaaatc aacccttcac gtagaaagca840cgttgtaaat gcataacact ctcatatcag tggttgattt gggaaaggtg gagagaattt900tcaattagtt ttgtgttgta ctattcaaat tttttacctc ttcactgtgt gtagagaaag960gagaagggaa ggaggatgag aaggaacgga agtcatcctg aaaataaaag tacaggactt 1020tttttttttt tttttgagac agggtctcaa aaaaggctgg agtacagtag tacagtggtg 1080ctatctcagc ttactgcagc ctcaacctcc tgggctcagg tgattctccc atctcagcct 1140ccctagtagc tgggactaca ggtgcgtgcc actatgccaa gctaattttt gtatttttag 1200tagagatggg ggttttccat attgcccagg ctggtcccga actcatggac tcaagtgatc 1260tgcctgcctc agcctcctaa agtgctgcga ttacaggcat gagccatcgc gcctaaagga 1320caggaccttt ttattgtatt tctttaaaga ataaatacat aacctgaatg caatcaagtc 1380tttagatcta attctcagct tgcagggaac actaggacaa atccaaaaag tgggtcagcg 1440ggcacagaat ggcccaattt tcaacaggaa aatgttataa aagaaaaata tttttgaggg 1500aactgttata gattaagaga atagaggcat gtttcagcta aacacatgta aactttgtca 1560
gagataattg ggaggagtat gtagaagaat cggattattg ttaattttgg taggtctgat 1620aatggtttta tagtataaag gctgagtacc ccttatccaa aatgattaag atcagaagtg 1680ttttggcttt cacatttttt tggattttgg aattttgcct ataataatga gacatcttgg 1740ggatgggatg caagtctaac cacaaaattc atttatgtct catacacact ttgaacacct 1800ggcctgaagg taatttcaca caatatttta aataactttg tgcatgaaac acaattttga 1860ctgcattttg actgcaactc atcacatgag gtcaggtatg gaattttcca cttgtggtgt 1920tacgttactg gctcaaaaag ttttggatct cggagcattc tggattttga atttttggat 1980tagtgatgct caacctgtat acagaaatgt cctcattttt aaaaaaagaa atgcatattt 2040atatgtttta aaattacttc aaccaaaagc aacggggaga tgtttactgt tatatttagg 2100tgacaggtac atggcaattc attataccct cctattttcc tatgtttaca ttattcatta 2160attaaaaaac aatacctaga aaaacccaag actttcaaaa gctattttct atatgtgcca 2220atctttaaaa aacaggataa caagggtatt tatcacatta aaatgttgta aaacagcaaa 2280gctaaaatct aaaaaaaaaa aaaaaaaa 2308<210>48<211>2880<212>DNA<213>人<400>48tgctgctctc cgcccgcgtc cggctcgtgg ccccctactt cgggcaccat ggacacctcc 60cggctcggtg tgctcctgtc cttgcctgtg ctgctgcagc tggcgaccgg gggcagctct120cccaggtctg gtgtgttgct gaggggctgc cccacacact gtcattgcga gcccgacggc180aggatgttgc tcagggtgga ctgctccgac ctggggctct cggagctgcc ttccaacctc240agcgtcttca cctcctacct agacctcagt atgaacaaca tcagtcagct gctcccgaat300cccctgccca gtctccgctt cctggaggag ttacgtcttg cgggaaacgc tctgacatac360attcccaagg gagcattcac tggcctttac agtcttaaag ttcttatgct gcagaataat420cagctaagac acgtacccac agaagctctg cagaatttgc gaagccttca atccctgcgt480ctggatgcta accacatcag ctatgtgccc ccaagctgtt tcagtggcct gcattccctg540aggcacctgt ggctggatga caatgcgtta acagaaatcc ccgtccaggc ttttagaagt600ttatcggcat tgcaagccat gaccttggcc ctgaacaaaa tacaccacat accagactat660gcctttggaa acctctccag cttggtagtt ctacatctcc ataacaatag aatccactcc720
ctgggaaaga aatgctttga tgggctccac agcctagaga ctttagattt aaattacaat780aaccttgatg aattccccac tgcaattagg acactctcca accttaaaga actaggattt840catagcaaca atatcaggtc gatacctgag aaagcatttg taggcaaccc ttctcttatt900acaatacatt tctatgacaa tcccatccaa tttgttggga gatctgcttt tcaacattta960cctgaactaa gaacactgac tctgaatggt gcctcacaaa taactgaatt tcctgattta 1020actggaactg caaacctgga gagtctgact ttaactggag cacagatctc atctcttcct 1080caaaccgtct gcaatcagtt acctaatctc caagtgctag atctgtctta caacctatta 1140gaagatttac ccagtttttc agtctgccaa aagcttcaga aaattgacct aagacataat 1200gaaatctacg aaattaaagt tgacactttc cagcagttgc ttagcctccg atcgctgaat 1260ttggcttgga acaaaattgc tattattcac cccaatgcat tttccacttt gccatcccta 1320ataaagctgg acctatcgtc caacctcctg tcgtcttttc ctataactgg gttacatggt 1380ttaactcact taaaattaac aggaaatcat gccttacaga gcttgatatc atctgaaaac 1440tttccagaac tcaaggttat agaaatgcct tatgcttacc agtgctgtgc atttggagtg 1500tgtgagaatg cctataagat ttctaatcaa tggaataaag gtgacaacag cagtatggac 1560gaccttcata agaaagatgc tggaatgttt caggctcaag atgaacgtga ccttgaagat 1620ttcctgcttg actttgagga agacctgaaa gcccttcatt cagtgcagtg ttcaccttcc 1680ccaggcccct tcaaaccctg tgaacacctg cttgatggct ggctgatcag aattggagtg 1740tggaccatag cagttctggc acttacttgt aatgctttgg tgacttcaac agttttcaga 1800tcccctctgt acatttcccc cattaaactg ttaattgggg tcatcgcagc agtgaacatg 1860ctcacgggag tctccagtgc cgtgctggct ggtgtggatg cgttcacttt tggcagcttt 1920gcacgacatg gtgcctggtg ggagaatggg gttggttgcc atgtcattgg ttttttgtcc 1980atttttgctt cagaatcatc tgttttcctg cttactctgg cagccctgga gcgtgggttc 2040tctgtgaaat attctgcaaa atttgaaacg aaagctccat tttctagcct gaaagtaatc 2100attttgctct gtgccctgct ggccttgacc atggccgcag ttcccctgct gggtggcagc 2160aagtatggcg cctcccctct ctgcctgcct ttgccttttg gggagcccag caccatgggc 2220tacatggtcg ctctcatctt gctcaattcc ctttgcttcc tcatgatgac cattgcctac 2280accaagctct actgcaattt ggacaaggga gacctggaga atatttggga ctgctctatg 2340gtaaaacaca ttgccctgtt gctcttcacc aactgcatcc taaactgccc tgtggctttc 2400ttgtccttct cctctttaat aaaccttaca tttatcagtc ctgaagtaat taagtttatc 2460
cttctggtgg tagtcccact tcctgcatgt ctcaatcccc ttctctacat cttgttcaat 2520cctcacttta aggaggatct ggtgagcctg agaaagcaaa cctacgtctg gacaagatca 2580aaacacccaa gcttgatgtc aattaactct gatgatgtcg aaaaacagtc ctgtgactca 2640actcaagcct tggtaacctt taccagctcc agcatcactt atgacctgcc tcccagttcc 2700gtgccatcac cagcttatcc agtgactgag agctgccatc tttcctctgt ggcatttgtc 2760ccatgtctct aattaatatg tgaaggaaaa tgttttcaaa ggttgagaac ctgaaaatgt 2820gagattgagt atatcagagc agtaattaat aagaagagct gaggtgaaac tcggtttaaa 2880<210>49<211>915<212>DNA<213>人<400>49atggatcccc tgggcccggc caagccacag tggtcgtggc gctgctgtct gaccacgctg60ctgtttcagc tgctgatggc tgtgtgtttc ttctcctatc tgcgtgtgtc tcaagacgat 120cccactgtgt accctaatgg gtcccgcttc ccagacagca cagggacccc cgcccactcc 180atccccctga tcctgctgtg gacgtggcct tttaacaaac ccatagctct gccccgctgc 240tcagagatgg tgcctggcac ggctgactgc aacatcactg ccgaccgcaa ggtgtatcca 300caggcagacg cggtcatcgt gcaccaccga gaggtcatgt acaaccccag tgcccagctc 360ccacgctccc cgaggcggca ggggcagcga tggatctggt tcagcatgga gtccccaagc 420cactgctggc agctgaaagc catggacgga tacttcaatc tcaccatgtc ctaccgcagc 480gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca gcctgcccac 540ccaccgctca acctctcggc caagaccgag ctggtggcct gggcagtgtc caactggggg 600ccaaactccg ccagggtgcg ctactaccag agcctgcagg cccatctcaa ggtggacgtg 660tacggacgct cccacaagcc cctgccccag ggaaccatga tggagacgct gtcccggtac 720aagttctatc tggccttcga gaactccttg caccccgact acatcaccga gaagctgtgg 780aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag aaggaacctc 840attttcctgg ggcctcacct gagtgggggc ctcatctacc taaggactcg tttgcctgaa 900gcttcacctg cctga915<210>50<211>1095
<212>DNA<213>人<400>50atggatcccc tgggcccggc caagccacag tggtcgtggc gctgctgtct gaccacgctg 60ctgtttcagc tgctgatggc tgtgtgtttc ttctcctatc tgcgtgtgtc tcaagacgat120cccactgtgt accctaatgg gtcccgcttc ccagacagca cagggacccc cgcccactcc180atccccctga tcctgctgtg gacgtggcct tttaacaaac ccatagctct gccccgctgc240tcagagatgg tgcctggcac ggctgactgc aacatcactg ccgaccgcaa ggtgtatcca300caggcagacg cggtcatcgt gcaccaccga gaggtcatgt acaaccccag tgcccagctc360ccacgctccc cgaggcggca ggggcagcga tggatctggt tcagcatgga gtccccaagc420cactgctggc agctgaaagc catggacgga tacttcaatc tcaccatgtc ctaccgcagc480gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca gcctgcccac540ccaccgctca acctctcggc caagaccgag ctggtggcct gggcagtgtc caactggggg600ccaaactccg ccagggtgcg ctactaccag agcctgcagg cccatctcaa ggtggacgtg660tacggacgct cccacaagcc cctgccccag ggaaccatga tggagacgct gtcccggtac720aagttctatc tggccttcga gaactccttg caccccgact acatcaccga gaagctgtgg780aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag aagcaactac840gagaggttcc tgccacccga cgccttcatc cacgtggacg acttccagag ccccaaggac900ctggcccggt acctgcagga gctggacaag gaccacgccc gctacctgag ctactttcgc960tggcgggaga cgctgcggcc tcgctccttc agctgggcac tcgctttctg caaggcctgc 1020tggaaactga aggaggaatc cagtgggggc ctcatctacc taaggactcg tttgcctgaa 1080gcttcacctg cctga1095<210>51<211>1182<212>DNA<213>人<400>51gtcctgagca gccaacacac cagcccagac agctgcaagt caccatggac gctgaaggcc 60tggcgctgct gctgccgccc gtcaccctgg cagccctggt ggacagctgg ctccgagagg120actgcccagg gctcaactac gcagccttgg tcagcggggc aggcccctcg caggcggcgc180tgtgggccaa atcccctggg gtactggcag ggcagccttt cttcgatgcc atatttaccc240
aactcaactg ccaagtctcc tggttcctcc ccgagggatc gaagctggtg ccggtggcca300gagtggccga ggtccggggc cctgcccact gcctgctgct gggggaacgg gtggccctca360acacgctggc ccgctgcagt ggcattgcca gtgctgccgc cgctgcagtg gaggccgcca420ggggggccgg ctggactggg cacgtggcag gcacgaggaa gaccacgcca ggcttccggc480tggtggagaa gtatgggctc ctggtgggcg gggccgcctc gcaccgctac gacctgggag540ggctggtgat gttgaaggat aaccatgtgg tgccccccgg tggcgtggag aaggcggtgc600gggcggccag acaggcggct gacttcgctc tgaaggtgga agtggaatgc agcagcctgc660aggaggtcgt ccaggcagct gaggctggcg ccgaccttgt cctgctggac aacttcaagc720cagaggagct gcaccccacg gccaccgcgc tgaaggccca gttcccgagt gtggctgtgg780aagccagtgg gggcatcacc ctggacaacc tcccccagtt ctgcgggccg cacatagacg840tcatctccat ggggatgctg acccaggcggtcccagccct tgatttctcc ctcaagctgt 900ttgccaaaga ggtggctcca gtgcccaaaa tccactagtc ctaaaccgga agaggatgac960accggccatg ggttaacgtg gctcctcagg accctctggg tcacacatct ttagggtcag 1020tgaacaatgg ggcacatttg gcactagctt gagcccaact ctggctctgc cacctgctgc 1080tcctgtgacc tgtcagggct gacttcacct ctgctcatct cagtttccta atctgtaaaa 1140tgggtctaat aaaggatcaa ccaaaaaaaa aaaaaaaaaa aa 1182<210>52<211>3600<212>DNA<213>人<400>52gaatcaacag aatttgtctt tttgtgactg gtttatttca cttaacttca tcctcaaggt 60tcaacttaaa ggtgtatcca tgttgtagca cgtgtcagca ttttctttcg ttctcaggct120aaatagtatt tcattgtgtg tgtacaccat gtttcatgca ttcattcatc ccttgaaaga180ttggtgggtt gtttcctcct ttttgctttt gtgaacagtg ctacgaacat ggttgtacaa240acatctcttg gagccccact agcagttcct ttgggtatat accccaaagt ggaattgctg300gatctggtag ctcccttttt aattttttga ggaatcgcca cacagtttcc ataacagctg360caccatttta cattcccaag accttttttt tttttttttt tttaagaaga aaagatgtgt420ttctgcattt ctggaagtct atgctgcatt tccatttgtt gaaatttaag accagagtca480tcttttctgc tgtaattata atggtcactg gcttgtgcct tttcctcctc tctctgcccc540
atctgcacgg ggtctttgaa caagtcccag caccttggtg gacaagcctg tgtccctggc600ccatcatgga agccgctgcc tttcagagtg ggagtctgta ccctgttgcc tcattccttg660ctgcgcccat gagtgagctt gtgcctgacc tctccttcca ggtggactta cacactgggc720tgtcggagtt ctcggtgacg cagcgccggc tggcccatgg ctggaatgag tttgttgctg780acaacagcga acctgtgtgg aagaaatacc tggatcagtt taagaacccc ctgatcctgc840tgctgctggg ctctgccctg gtgagtgtcc tcaccaagga gtatgaggac gccgtcagca900tcgccacggc agtgcttgtc gtggtcactg tcgccttcat ccaggagtac aggtcggaga960aatctctgga agagctgacc aagctggttc ctccagaatg taactgccta agagaaggaa 1020aactccagca cctgcttgct cgagaactgg ttcctggtga tgtcgtatct ctctcgatcg 1080gagaccggat ccctgcagac atccgactca ctgaggtcac ggacctcttg gtggatgaat 1140ccagtttcac cggggaagcc gagccatgta gtaaaacaga cagccccttg acaggcggtg 1200gggacctcac caccctcagc aacatcgtct tcatggggac cctggtgcag tatgggaggg 1260gccagggggt cgtgattgga acaggggaaa gctctcagtt cggagaagtg tttaagatga 1320tgcaggctga agagacacct aaaactcctt tgcagaaaag catggacagg ctaggaaagc 1380aactgacact cttctccttt ggcataatcg gtctcatcat gctcattggc tggtcgcaag 1440ggaaacaact cctgagtatg ttcacgatcg gggtcagcct ggctgtggcg gctattccag 1500agggtctgcc catcgtcgtc atggtgacgc tggtcctggg agtgctgcgg atggccaaga 1560agcgggtcat cgtgaagaag ttacccatcg tggagacttt aggttgctgc agcgttctct 1620gttctgacaa gacggggact ctgactgcca atgaaatgac agtgacccag cttgtaacgt 1680cagatgggct tcgtgccgag gtcagcggag ttgggtatga cggtcaaggg actgtgtgtc 1740ttctaccatc caaggaagtc attaaggaat tttccaatgt ctcagtggga aagttagtgg 1800aggcgggctg tgttgccaac aatgcggtca tcagaaagaa cgccgtgatg gggcagccca 1860ccgagggtgc attgatggcc ctggcgatga agatggactt aagtgatatt aaaaattcat 1920atataagaaa aaaagagatt ccattcagtt cagagcagaa gtggatggcg gtgaaatgca 1980gtctgaagac tgaggatcag gaagacattt acttcatgaa aggggccttg gaagaggtga 2040tccgctactg caccatgtac aacaacgggg gcatccccct gccgctgacg ccccagcaga 2100ggtcattctg cctgcaggaa gagaagagga tggggtcgct cggtttgcgg gtgctggccc 2160tggcttctgg gcccgagctg gggcggctga cgtttctagg tcttgtgggc atcattgacc 2220ccccgagagt tggcgtgaag gaagcagtcc aggttctctc cgagtctggt gtgtctgtga 2280
agatgataac gggggatgcc ctggagacgg ccttggccat aggaagaaac atcggcctgt 2340gcaacgggaa gctgcaagcc atgtccgggg aggaggtgga cagcgtggag aagggcgagc 2400tggccgaccg cgtggggaag gtgtccgtgt tcttcaggac cagcccaaag cacaagctca 2460aaatcatcaa ggctctgcag gagtcagggg cgatcgtggc catgactggg gatggggtga 2520acgacgcagt ggccctgaag tctgcagaca ttgggatcgc catggggcag acagggacgg 2580acgtcagcaa agaggccgcc aacatgatcc tggtggatga tgacttctca gccatcatga 2640atgcagtgga ggaaggcaag ggtatttttt acaacatcaa aaactttgtc cgattccagc 2700tgagcacgag catctccgcc ctgagtctca tcactctgtc caccgtgttc aacctgccca 2760gccccctcaa cgccatgcag atcctatgga tcaacatcat catggatggg ccaccggcgc 2820agagcttggg ggtagagccc gttgacaaag acgccttcag gcagccacca cggagtgtgc 2880gggacaccat cctcagcaga gccctcatcc tgaagatcct catgtccgcg gccatcatca 2940tcagcgggac cctctttatc ttctggaagg agatgcctga agacagagca agcactcccc 3000gcaccacgac gatgacgttc acttgttttg tgtttttcga tctcttcaac gccttgacct 3060gccgctctca gaccaagctg atatttgaga tcggctttct caggaaccac atgttcctct 3120actccgtcct ggggtccatc ctggggcagc tggcggtcat ttacatcccc ccgctgcaga 3180gggtcttcca gacggagaac ctgggagcgc ttgatttgct gtttttaact ggattggcct 3240catccgtctt cattttgtca gagctcctca aactatgtga aaaatactgt tgcagcccca 3300agagagtcca gatgcaccct gaagatgtgt agtggaccgc actccgcggc accttcccta 3360atcatctcga tctggttgtg actgtggccc ctgccgtgtc tcctcgtcag gggagacttt 3420taggaggccg cagccttcca tcaccggatc agtttttcct cttaggaaag ctgcaggaac 3480ctcgtgggct ccagggaccc aggcccacat ccatccagcg ttcccgctgg ctgtgggaca 3540gacagggagg ggcctgtaca gaaacaccac actgtttatt aaatcacaat gatttttatt 3600<210>53<211>4192<212>DNA<213>人<400>53tccaagctca aagaagcaga ggccgctgtt cgtttccttt aggtctttcc actaaagtcg 60gagtatcttc ttccaagatt tcacgtcttg gtggccgttc caaggagcgc gaggtcggga120tggatcttga aggggaccgc aatggaggag caaagaagaa gaactttttt aaactgaaca180
ataaaagtga aaaagataag aaggaaaaga aaccaactgt cagtgtattt tcaatgtttc240gctattcaaa ttggcttgac aagttgtata tggtggtggg aactttggct gccatcatcc300atggggctgg acttcctctc atgatgctgg tgtttggaga aatgacagat atctttgcaa360atgcaggaaa tttagaagat ctgatgtcaa acatcactaa tagaagtgat atcaatgata420cagggttctt catgaatctg gaggaagaca tgaccaggta tgcctattat tacagtggaa480ttggtgctgg ggtgctggtt gctgcttaca ttcaggtttc attttggtgc ctggcagctg540gaagacaaat acacaaaatt agaaaacagt tttttcatgc tataatgcga caggagatag600gctggtttga tgtgcacgat gttggggagc ttaacacccg acttacagat gatgtctcca660agattaatga aggaattggt gacaaaattg gaatgttctt tcagtcaatg gcaacatttt720tcactgggtt tatagtagga tttacacgtg gttggaagct aacccttgtg attttggcca780tcagtcctgt tcttggactg tcagctgctg tctgggcaaa gatactatct tcatttactg840ataaagaact cttagcgtat gcaaaagctg gagcagtagc tgaagaggtc ttggcagcaa900ttagaactgt gattgcattt ggaggacaaa agaaagaact tgaaaggtac aacaaaaatt960tagaagaagc taaaagaatt gggataaaga aagctattac agccaatatt tctataggtg 1020ctgctttcct gctgatctat gcatcttatg ctctggcctt ctggtatggg accaccttgg 1080tcctctcagg ggaatattct attggacaag tactcactgt attttctgta ttaattgggg 1140cttttagtgt tggacaggca tctccaagca ttgaagcatt tgcaaatgca agaggagcag 1200cttatgaaat cttcaagata attgataata agccaagtat tgacagctat tcgaagagtg 1260ggcacaaacc agataatatt aagggaaatt tggaattcag aaatgttcac ttcagttacc 1320catctcgaaa agaagttaag atcttgaagg gtctgaacct gaaggtgcag agtgggcaga 1380cggtggccct ggttggaaac agtggctgtg ggaagagcac aacagtccag ctgatgcaga 1440ggctctatga ccccacagag gggatggtca gtgttgatgg acaggatatt aggaccataa 1500atgtaaggtt tctacgggaa atcattggtg tggtgagtca ggaacctgta ttgtttgcca 1560ccacgatagc tgaaaacatt cgctatggcc gtgaaaatgt caccatggat gagattgaga 1620aagctgtcaa ggaagccaat gcctatgact ttatcatgaa actgcctcat aaatttgaca 1680ccctggttgg agagagaggg gcccagttga gtggtgggca gaagcagagg atcgccattg 1740cacgtgccct ggttcgcaac cccaagatcc tcctgctgga tgaggccacg tcagccttgg 1800acacagaaag cgaagcagtg gttcaggtgg ctctggataa ggccagaaaa ggtcggacca 1860
ccattgtgat agctcatcgt ttgtctacag ttcgtaatgc tgacgtcatc gctggtttcg 1920atgatggagt cattgtggag aaaggaaatc atgatgaact catgaaagag aaaggcattt 1980acttcaaact tgtcacaatg cagacagcag gaaatgaagt tgaattagaa aatgcagctg 2040atgaatccaa aagtgaaatt gatgccttgg aaatgtcttc aaatgattca agatccagtc 2100taataagaaa aagatcaact cgtaggagtg tccgtggatc acaagcccaa gacagaaagc 2160ttagtaccaa agaggctctg gatgaaagta tacctccagt ttccttttgg aggattatga 2220agctaaattt aactgaatgg ccttattttg ttgttggtgt attttgtgcc attataaatg 2280gaggcctgca accagcattt gcaataatat tttcaaagat tataggggtt tttacaagaa 2340ttgatgatcc tgaaacaaaa cgacagaata gtaacttgtt ttcactattg tttctagccc 2400ttggaattat ttcttttatt acatttttcc ttcagggttt cacatttggc aaagctggag 2460agatcctcac caagcggctc cgatacatgg ttttccgatc catgctcaga caggatgtga 2520gttggtttga tgaccctaaa aacaccactg gagcattgac taccaggctc gccaatgatg 2580ctgctcaagt taaaggggct ataggttcca ggcttgctgt aattacccag aatatagcaa 2640atcttgggac aggaataatt atatccttca tctatggttg gcaactaaca ctgttactct 2700tagcaattgt acccatcatt gcaatagcag gagttgttga aatgaaaatg ttgtctggac 2760aagcactgaa agataagaaa gaactagaag gtgctgggaa gatcgctact gaagcaatag 2820aaaacttccg aaccgttgtt tctttgactc aggagcagaa gtttgaacat atgtatgctc 2880agagtttgca ggtaccatac agaaactctt tgaggaaagc acacatcttt ggaattacat 2940tttccttcac ccaggcaatg atgtattttt cctatgctgg atgtttccgg tttggagcct 3000acttggtggc acataaactc atgagctttg aggatgttct gttagtattt tcagctgttg 3060tctttggtgc catggccgtg gggcaagtca gttcatttgc tcctgactat gccaaagcca 3120aaatatcagc agcccacatc atcatgatca ttgaaaaaac ccctttgatt gacagctaca 3180gcacggaagg cctaatgccg aacacattgg aaggaaatgt cacatttggt gaagttgtat 3240tcaactatcc cacccgaccg gacatcccag tgcttcaggg actgagcctg gaggtgaaga 3300agggccagac gctggctctg gtgggcagca gtggctgtgg gaagagcaca gtggtccagc 3360tcctggagcg gttctacgac cccttggcag ggaaagtgct gcttgatggc aaagaaataa 3420agcgactgaa tgttcagtgg ctccgagcac acctgggcat cgtgtcccag gagcccatcc 3480tgtttgactg cagcattgct gagaacattg cctatggaga caacagccgg gtggtgtcac 3540aggaagagat tgtgagggca gcaaaggagg ccaacataca tgccttcatc gagtcactgc 3600
ctaataaata tagcactaaa gtaggagaca aaggaactca gctctctggt ggccagaaac 3660aacgcattgc catagctcgt gcccttgtta gacagcctca tattttgctt ttggatgaag 3720ccacgtcagc tctggataca gaaagtgaaa aggttgtcca agaagccctg gacaaagcca 3780gagaaggccg cacctgcatt gtgattgctc accgcctgtc caccatccag aatgcagact 3840taatagtggt gtttcagaat ggcagagtca aggagcatgg cacgcatcag cagctgctgg 3900cacagaaagg catctatttt tcaatggtca gtgtccaggc tggaacaaag cgccagtgaa 3960ctctgactgt atgagatgtt aaatactttt taatatttgt ttagatatga catttattca 4020aagttaaaag caaacactta cagaattatg aagaggtatc tgtttaacat ttcctcagtc 4080aagttcagag tcttcagaga cttcgtaatt aaaggaacag agtgagagac atcatcaagt 4140ggagagaaat catagtttaa actgcattat aaattttata acagaattaa ag 4192<210>54<211>771<212>DNA<213>人<400>54gctgtctcta cacacgtggc cctcggggcc tacgccccgc tcacaaagca tgggacactg 60gtggtggagg atgtggtggc atcctgcttc gcggccgtgg ctgaccacca cctggctcag120ttggccttct ggcccctgag actctttcac agcttggcat ggggcagctg gaccccgggg180gagggtgtgc attggtaccc ccagctgctc taccgcctgg ggcgtctcct gctagaagag240ggcagcttcc acccactggg catgtccggg gcagggagct gaaaggactc caccgctgcc300ctcctggaac tgctgtactg ggtccagaag cctctcagcc aggagggagc tggccctgga360agggacctga gctgggggac actggctcct gccatctcct ctgccatgaa gatacaccat420tgagacttga ctgggcaaca ccagcgtccc ccacccgcgc gtggtgtagt catagagctg480caagctgagc tggcgagggg atggttgttg acccctctct cctagagacc ttgaggctgg540cacgggactc ccaactcagc ctgctctcac tacgagtttt catactctgc ctcccccatt600ggggagggcc cattccatcc atctttaggc ccctttgggt gggcttgcgc ctcagtttga660tgctgctaaa ttcccctggg agccagcatg gatctggtgg accgatgctg tcagaactgg720gaaggcacca gggtggggca gcatcccggg cattctgagg tatgacattc c 771<210>55<211>4446
<212>DNA<213>人<400>55ttcttaaccc tttccagctt tcccaccctc tttggcttta gccatggcct tctgatctgt 60gtttctcagg ggacctgcag gccccagata tagccccatg ctgtcctcct accccagagc120acactgttca ggctacttcc actggtactg aaatccagta tttcacttac tcttttcctt180tccaatatcc tcatgacatt caatatttca cttactctag gtcctccctg cctaaggccc240aagtcaactt tctgtccagt gggatttgta atccaatgcc tcctagccct agcagaatcc300catgtggata atcagaaatg tgactggaaa aaggacagag ctctatggct gtgggtccca360gtccccactg ctggcagtaa gtccccagca gtgagctgtg taagcacctt acattctgcg420cttggttgaa aacagcaagg caagcatcca cttgagaaat gtcaacccct aggaaatccc480agcctcaagt ctttctcatc ccttgggaag tgcaaattgg atagagaaga aaccaattaa540aaacaaaaca aacaaatcat acttagatat tctggctttt ctcaccaggg ctggattaaa600gcatgtactt caaaataata acaacttaag tcaataaata aatgtaagga agtccaaatg660ttcacctgaa gacaactgtg gtcatttttt ggcaatccca ggttctcttt tctacctgtt720tgctcaatcg tggtctccct ctccctctct tgttggggcc catgcccctg ctttactgtt780gccagaggct tgtacttgtt tgccttttag gtaggagcag ttacttccac tcccctcacc840tgccataaag catctttata aacaaagcaa gtagaagaaa cacatcctgg tatccaccac900attcggcttt tgttgattct gttcacttgg gagcacctgc tgctagggaa taagaaggtt960gaggctgaag agtgaggact cttcagctcc cctctggcag gacccgggag aggaaagagc 1020cctcagctgg tccatcctcc ccactcctgg tcagccttct gttctgagat caaagtggtg 1080gggtcacatt ctcgagaact gtgctcagcc ccctcatctc acaccctttc cctctccctg 1140tgtgcctgcc cccctcttac ataaccatgc tggtgattgg caccgtcata aatcaatact 1200ttgctcactt tcacatcaag taacactatc cagggaggtg gtttcaacaa aggaggaagt 1260ataaggagat ctaggttcaa attaatgttg cccctagtgg taaaggacag agaccctcag 1320actgatgaaa tgcactcaga attacttaga caaagcggat atttgccact ctcttcccct 1380tttcctgtgt ttttgtagtg aagagacctg aaagaaaaaa gtagggagaa cataatgaga 1440acaaatacgg taatctcttc atttgctagt tcaagtgctg gacttgggac ttaggagggg 1500caatggagcc gcttagtgcc tacatctgac ttggactgaa atataggtga gagacaagat 1560tgtctcatat ccggggaaat cataacctat gactaggacg ggaagaggaa gcactgcctt 1620
tacttcagtg ggaatctcgg cctcagcctg caagccaagt gttcacagtg agaaaagcaa 1680gagaataagc taatactcct gtcctgaaca aggcagcggc tccttggtaa agctactcct 1740tgatcgatcc tttgcaccgg attgttcaaa gtggacccca ggggagaagt cggagcaaag 1800aacttaccac caagcagtcc aagaggccca gaagcaaacc tggaggtgag acccaaagaa 1860agctggaacc atgctgactt tgtacactgt gaggacacag agtctgttcc tggaaagccc 1920agtgtcaacg cagatgagga agtcggaggt ccccaaatct gccgtgtatg tggggacaag 1980gccactggct atcacttcaa tgtcatgaca tgtgaaggat gcaagggctt tttcaggagg 2040gccatgaaac gcaacgcccg gctgaggtgc cccttccgga agggcgcctg cgagatcacc 2100cggaagaccc ggcgacagtg ccaggcctgc cgcctgcgca agtgcctgga gagcggcatg 2160aagaaggaga tgatcatgtc cgacgaggcc gtggaggaga ggcgggcctt gatcaagcgg 2220aagaaaagtg aacggacagg gactcagcca ctgggagtgc aggggctgac agaggagcag 2280cggatgatga tcagggagct gatggacgct cagatgaaaa cctttgacac taccttctcc 2340catttcaaga atttccggct gccaggggtg cttagcagtg gctgcgagtt gccagagtct 2400ctgcaggccc catcgaggga agaagctgcc aagtggagcc aggtccggaa agatctgtgc 2460tctttgaagg tctctctgca gctgcggggg gaggatggca gtgtctggaa ctacaaaccc 2520ccagccgaca gtggcgggaa agagatcttc tccctgctgc cccacatggc tgacatgtca 2580acctacatgt tcaaaggcat catcagcttt gccaaagtca tctcctactt cagggacttg 2640cccatcgagg accagatctc cctgctgaag ggggccgctt tcgagctgtg tcaactgaga 2700ttcaacacag tgttcaacgc ggagactgga acctgggagt gtggccggct gtcctactgc 2760ttggaagaca ctgcaggtgg cttccagcaa cttctactgg agcccatgct gaaattccac 2820tacatgctga agaagctgca gctgcatgag gaggagtatg tgctgatgca ggccatctcc 2880ctcttctccc cagaccgccc aggtgtgctg cagcaccgcg tggtggacca gctgcaggag 2940caattcgcca ttactctgaa gtcctacatt gaatgcaatc ggccccagcc tgctcatagg 3000ttcttgttcc tgaagatcat ggctatgctc accgagctcc gcagcatcaa tgctcagcac 3060acccagcggc tgctgcgcat ccaggacata cacccctttg ctacgcccct catgcaggag 3120ttgttcggca tcacaggtag ctgagcggct gcccttgggt gacacctccg agaggcagcc 3180agacccagag ccctctgagc cgccactccc gggccaagac agatggacac tgccaagagc 3240cgacaatgcc ctgctggcct gtctccctag ggaattcctg ctatgacagc tggctagcat 3300
tcctcaggaa ggacatgggt gccccccacc cccagttcag tctgtaggga gtgaagccac 3360agactcttac gtggagagtg cactgacctg taggtcagga ccatcagaga ggcaaggttg 3420ccctttcctt ttaaaaggcc ctgtggtctg gggagaaatc cctcagatcc cactaaagtg 3480tcaaggtgtg gaagggacca agcgaccaag gataggccat ctggggtcta tgcccacata 3540cccacgtttg ttcgcttcct gagtcttttc attgctacct ctaatagtcc tgtctcccac 3600ttcccactcg ttcccctcct cttccgagct gctttgtggg ctccaggcct gtactcatcg 3660gcaggtgcat gagtatctgt gggagtcctc tagagagatg agaagccagg aggcctgcac 3720caaatgtcag aagcttggca tgacctcatt ccggccacat cattctgtgt ctctgcatcc 3780atttgaacac attattaagc accgataata ggtagcctgc tgtggggtat acagcattga 3840ctcagatata gatcctgagc tcacagagtt tatagttaaa aaaacaaaca gaaacacaaa 3900caatttggat caaaaggaga aatgataagt gacaaaagca gcacaaggaa tttccctgtg 3960tggatgctga gctgtgatgg cgggcactgg gtacccaagt gaaggttccc gaggacatga 4020gtctgtagga gcaagggcac aaactgcagc tgtgagtgcg tgtgtgtgat ttggtgtagg 4080taggtctgtt tgccacttga tggggcctgg gtttgttcct ggggctggaa tgctgggtat 4140gctctgtgac aaggctacgc tgacaatcag ttaaacacac cggagaagaa ccatttacat 4200gcaccttata tttctgtgta cacatctatt ctcaaagcta aagggtatga aagtgcctgc 4260cttgtttata gccacttgtg agtaaaaatt tttttgcatt ttcacaaatt atactttata 4320taaggcattc cacacctaag aactagtttt gggaaatgta gccctgggtt taatgtcaaa 4380tcaaggcaaa aggaattaaa taatgtactt ttggctaaaa aaaaaaaaaa aaaaaaaaaa 4440aaaaaa 4446<210>56<211>1276<212>DNA<213>人<400>56tgagatcact tcccttgcac agtttggaag ggagagcact ttattacaga ccttggaagc 60aagaggattg cattcagcct agttcctggt tgctggccaa agggatcatg gacattgaag120catattttga aagaattggc tataagaact ctaggaacaa attggacttg gaaacattaa180ctgacattct tgagcaccag atccgggctg ttccctttga gaaccttaac atgcattgtg240ggcaagccat ggagttgggc ttagaggcta tttttgatca cattgtaaga agaaaccggg300
gtgggtggtg tctccaggtc aatcaacttc tgtactgggc tctgaccaca atcggttttc360agaccacaat gttaggaggg tatttttaca tccctccagt taacaaatac agcactggca420tggttcacct tctcctgcag gtgaccattg acggcaggaa ttacattgtc gatgctgggt480ctggaagctc ctcccagatg tggcagcctc tagaattaat ttctgggaag gatcagcctc540aggtgccttg cattttctgc ttgacagaag agagaggaat ctggtacctg gaccaaatca600ggagagagca gtatattaca aacaaagaat ttcttaattc tcatctcctg ccaaagaaga660aacaccaaaa aatatactta tttacgcttg aacctcgaac aattgaagat tttgagtcta720tgaatacata cctgcagacg tctccaacat cttcatttat aaccacatca ttttgttcct780tgcagacccc agaaggggtt tactgtttgg tgggcttcat cctcacctat agaaaattca840attataaaga caatacagat ctggtcgagt ttaaaactct cactgaggaa gaggttgaag900aagtgctgaa aaatatattt aagatttcct tggggagaaa tctcgtgccc aaacctggtg960atggatccct tactatttag aataaggaac aaaataaacc cttgtgtatg tatcacccaa 1020ctcactaatt atcaacttat gtgctatcag atatcctctc taccctcacg ttattttgaa 1080gaaaatccta aacatcaaat actttcatcc ataaaaatgt cagcatttat taaaaaacaa 1140taacttttta aagaaacata aggacacatt ttcaaattaa taaaaataaa ggcattttaa 1200ggatggcctg tgattatctt gggaagcaga gtgattcatg ctagaaaaca tttaatattg 1260atttattgtt gaattc 1276<210>57<211>4999<212>DNA<213>人<400>57gaggaggatt cgcagttcaa catcaaggtc cctgtgcgtt ttattgcgac ctgccggtgg 60gaactttgtc tccgagtcgg agcagcatgg agcggcggag cgagagcccg tgtctgcggg120acagccccga ccggcggagc ggcagcccgg acgtcaaggg gcctccccca gtgaaggtgg180cccggctgga gcagaacggc agccccatgg gagcccgcgg gaggcccaac ggcgccgtgg240ccaaggccgt gggaggtttg atgattcctg tcttttgtgt cgtggagcag ttggacggct300ctcttgaata tgacaacaga gaagaacacg ccgagtttgt cctggtgcgg aaagatgtgc360tttttagcca gctggtggag actgcgctcc tggccctggg gtattctcac agctctgcgg420cccaggccca aggaataatc aagctgggaa ggtggaaccc tctccccctc agttatgtga480
cagatgcacc cgacgcgaca gtggccgaca tgctacaaga tgtctatcat gttgtgacgt540tgaaaatcca attacaaagt tgttcaaagt tggaagactt gcctgcggag cagtggaacc600atgccacagt ccgcaatgcc ttaaaggaac tgctcaaaga gatgaaccag agcacattag660ccaaagaatg ccctctctcc cagagtatga tttcatccat tgtaaatagc acatattatg720ccaatgtgtc agcaaccaag tgccaggagt ttgggagatg gtataaaaag tacaagaaga780ttaaagtgga aagagtggaa cgagaaaacc tttcagacta ttgtgttctg ggccagcgtc840caatgcattt accaaatatg aaccagctgg catccctggg gaaaaccaac gaacagtctc900ctcacagcca aattcaccac agtactccaa tccgaaacca agtgcccgca ttacagccca960tcatgagccc tggtcttctt tctccccagc ttagtccaca acttgtaagg caacaaatag 1020ccatggccca tctgataaac caacagattg ccgttagccg gctcctggct caccagcatc 1080ctcaagccat caaccagcag ttcctgaacc atccacccat ccccagagca gttaagccag 1140agccaaccaa ctcttccgtg gaagtctctc cagatatcta ccagcaagtc agagatgagc 1200tgaagagggc cagtgtgtcc caagctgtct ttgcaagagt ggcattcaac cgcacacagg 1260gattgttgtc tgagattctg cgtaaggaag aagaccctcg gacagcctct cagtctcttc 1320tagtaaacct gagggccatg cagaatttcc tcaatctgcc agaagtggag cgagatcgca 1380tctaccagga tgagagggag cggagcatga atcccaatgt gagcatggtc tcctcggcct 1440ccagcagtcc cagctcctcc cgaacccctc aggccaaaac ctcgacaccg acaacagacc 1500tccctattaa ggtggacggc gccaacatca acatcacagc tgccatttat gacgagatcc 1560aacaggagat gaaaagggcc aaggtgtctc aagccctgtt tgccaaagtg gctgcaaata 1620aaagtcaggg ctggctgtgt gaactgctcc gctggaagga gaacccaagc ccagaaaacc 1680gcaccctctg ggaaaacctc tgtaccatcc gtcgcttcct gaaccttccc cagcatgaga 1740gggatgtcat ctatgaggag gagtcaaggc atcaccacag cgaacgcatg caacacgtgg 1800tccagcttcc ccctgagccg gtgcaggtac ttcatagaca gcagtctcag ccagccaagg 1860agagttcccc tcccagagaa gaagcgcctc ccccacctcc tccgactgaa gacagttgtg 1920ccaaaaagcc ccggtctcgc acaaagatct ccttagaagc cctggggatc ctccaaagct 1980ttattcatga tgtaggcctg tacccagacc aggaagccat ccacactctt tcggctcagc 2040tggatctccc caaacacacc atcatcaagt tcttccagaa ccagcggtac cacgtgaagc 2100accacgggaa gctgaaagag cacctgggct ccgcggtgga cgtggctgaa tataaggacg 2160aggagctgct gaccgagtca gaggagaacg acagcgagga aggctccgag gagatgtaca 2220
aagtggaggc tgaggaggaa aatgctgaca aaagcaaggc agcacctgcc gaaattgacc 2280agagataatg tgaacttcta ctaggcaaag caatacatcg gtccaaggat tttctgcttt 2340catttcttta aaagtttttt gttagtttgt tttttgtttt tgtttttggg tttttttggc 2400tttatttttg tctttttatg tctgttttgt ttttcttacc cttttggaca tttctttgtt 2460gcacaggata cacctataga ctgaataagt tcagtatttc cgaatcagac atcgccttgg 2520caaagacact aaagcgttac actttatccc gtctctatga ctggatcata gtcattataa 2580tcacaggaga ctctgccttc attatccttg cacttaacgg aagttacatc aggcaagttc 2640caggatgaaa agaactatga aataaatgaa ggaagctaca agtgtgtgtg tatatgtata 2700tgtatatatc tctatattta catatatata ttaaaattgc atgggacaga gactttgcaa 2760tccgaaagaa tagactgtga aatgagttct taaagaaaag acttgtttat gtattaaaaa 2820aaccacttca cagtgagtcg ctttggcttt ttgataaact gcggcctgct ctcagggtgg 2880ggtgactatt tttgaattcc tatttatttt ttgtgtttgt ccctgatttt tttttttaat 2940tctatggctt cctatctggc agcttaatgg gtaatttttg aggtatgtat ttaacaaaat 3000aaacgacact gccgaaaaaa aaaaaagtga agtgaaaaca atcagggcac attaaaatga 3060tacaagtcaa ataaatctta aagacacaat gcacacttaa aatgactcaa taaaatgact 3120tgctacgttc cgttattcaa tttgtcatta ctgtagtgaa cagatgcatt tctgtggaat 3180tccaaataag taaaactgaa attcagtgca gagaaaactt tgtccactag tgcaagtctt 3240gatcaaatga cattttgaca ttggacatat ggaattcata gtatgagcca cattttgttg 3300tgaaatttat ttacctgctt gtggcttcaa atctgaaaat taataagcct gctcgtttaa 3360aagttgtttg ttgttgctgt ttttttgtct ttttgttttt tactagaaaa tagttcagtg 3420taatattaag ttagaaaaga agttgctgcc cagttaaagg ggctccctct caaataaatc 3480tccatccttc cctctcccaa aagacatttc tgatttctgc ttcactttgg gcttcctctt 3540cttcgtacac attccatcta cctaatcaaa cattttcagt ccctgatctc tcctgtccct 3600tttcctggga tgacagccct aacaagaact gtttttgaat cgttgtgcag ctccaggcaa 3660tagagtatgt gaagcgattt cagtagaatc acttactcat cctaaaagaa aacattatcc 3720cagttaccta catcgcaatt accttatgta aagcagaact aatgctgact ggatgtttaa 3780tgggatgagc attaaagctg caatctacta tagtactcca gatctctttc ggcttcctat 3840gagaaacacc agaagcatta ctttccactt ctacttacag taattgcaag aggagacctc 3900
acattcagga ctggcctagt gaacgtaatc catgctttaa actggccatt aaacagtccc 3960acatggttgg attttttttt tttttttgag ttgtgctttc acaaaacctt gtcaaagacc 4020tcatgcaata tcactttgaa agttattttc tgtttactac acaaacattg taatataact 4080gttaatacta tttatatatt tgaaaggtat aaaaggtagg agttaaaaaa aaaacctcta 4140tgtgtagata ttaactcaga acttacaata tacagggaga agacatgttg caatacaagc 4200taattctagc tgctcagtaa cctctggagt ttttaaaggg acattttcct gtactttttc 4260aaataatgat gtttaaaaat tatcttgaca taagcgtcat atacctttgc aaaaggatgg 4320ttgtttgcag ttagccctgg ccccatcctt cctatttctg tagtatgctg cagctttaat 4380cagaaagtcc atggttgctg cttcctgatc tccgagttac tctttccaaa ttgtcttctt 4440acactgttgc tgaaggtcac tctgtacacg taatggaaac tgattttgcc aagctcttac 4500aaggtggttc atctatcgat ggcatccgca tttggtatct tttacacttc aaccaaaaat 4560ttattaggta tttttcaatg ctaagtcttg ccttttattt tttaatttca ctgccaagtt 4620tgcagtggtt ctaagtgaat ctgtgggcat tttagcctgt ggtcttgcca gatctttgcg 4680aattacaatg catatatgtc tatttattca atatctgtca tataatatct atttggaaga 4740agaaactttc tcttgtagtg cctcttgaca aagcacaatt tcccgccttt tttttttttt 4800ttgtgaaatg aaaaaaacaa attgtgtttt attgcggtat caacaatgtg aataaggatt 4860aacatattgt aaatgttctt ttttccatgt aaatcaacta tctttgttat cactaagtga 4920taattaattt ttaacttatg tgcattgtta ggctgttaga attttttggt tgttaaaata 4980aacgcattca ataaatatg4999<210>58<211>1117<212>DNA<213>人<400>58atctcccact cctgcagctc ttctcacagg accagccact agcgcagcct cgagcgatgg 60cctatgtccc cgcaccgggc taccagccca cctacaaccc gacgctgcct tactaccagc120ccatcccggg cgggctcaac gtgggaatgt ctgtttacat ccaaggagtg gccagcgagc180acatgaagcg gttcttcgtg aactttgtgg ttgggcagga tccgggctca gacgtcgcct240tccacttcaa tccgcggttt gacggctggg acaaggtggt cttcaacacg ttgcagggcg300ggaagtgggg cagcgaggag aggaagagga gcatgccctt caaaaagggt gccgcctttg360
agctggtctt catagtcctg gctgagcact acaaggtggt ggtaaatgga aatcccttct420atgagtacgg gcaccggctt cccctacaga tggtcaccca cctgcaagtg gatggggatc480tgcaacttca atcaatcaac ttcatcggag gccagcccct ccggccccag ggacccccga540tgatgccacc ttaccctggt cccggacatt gccatcaaca gctgaacagc ctgcccacca600tggaaggacc cccaaccttc aacccgcctg tgccatattt cgggaggctg caaggagggc660tcacagctcg aagaaccatc atcatcaagg gctatgtgcc tcccacaggc aagagctttg720ctatcaactt caaggtgggc tcctcagggg acatagctct gcacattaat ccccgcatgg780gcaacggtac cgtggtccgg aacagccttc tgaatggctc gtggggatcc gaggagaaga840agatcaccca caacccattt ggtcccggac agttctttga tctgtccatt cgctgtggct900tggatcgctt caaggtttac gccaatggcc agcacctctt tgactttgcc catcgcctct960cggccttcca gagggtggac acattggaaa tccagggtga tgtcaccttg tcctatgtcc 1020agatctaatc tattcctggg gccataactc atgggaaaac agaattatcc cctaggactc 1080ctttctaagc ccctaataaa atgtctgagg gtgtctc1117<210>59<211>2246<212>DNA<213>人<400>59gatccagcta tggagaaagc cgcagatctg caggacacag cctcgttaac tctgaagttt 60aagtttaacc caaagctggg cattgataat cctgtcctct ccctggccga agaccacgac120ccctatgatc cctggagcct ggagcggcct cgcttctgtt tactgagcaa agaggagggc180aagagttttg gcttccacct gcagcaggag ctgggcaggg ctgggcatgt ggtgtgcagg240gtggacccag gcacctctgc ccagcgccag ggtcttcagg aaggagacag gatcctggcg300gtgaacaatg atgttgtgga acacgaagac tatgcggtgg tggtacgccg catccgggcc360agcagccctc gggtgttgct gacagtattg gcacggcatg cacatgacgt ggcccgagct420cagctgggag aagatgccca cctctgtccc accctaggcc caggggtccg gccccggctg480tgccacatag tgaaagatga gggtggtttt ggcttcagtg tcacccatgg caatcagggt540cctttctggt tggtgctaag tactggagga gcagctgagc gggcaggggt gccccccggg600gcccggctgc tggaagtgaa tgggctttgg cagagtggac agcaggtgac cttgctggtg660gcagggccag aggtggaaga acagtgtcgc cagctgggat tgcccctggc tgcacccctg720
gcagagggct gggcactgcc caccaagccc cgctgcctgc acctggagaa agggccccag780ggttttgggt tcctgctccg ggaggaaaag ggccttgacg gtcgccctgg acagttcctg840tgggaggtgg acccgggact gccagccaag aaggctggga tgcaggctgg ggaccggctg900gtggctgtgg ctggggagag cgtggagggg ctgggccatg aggagacagt gtccaggatc960caggggcagg gctcctgtgt ctccctcact gtcgtcgacc ctgaggcgga ccgcttcttc 1020agcatggttc gcctgtcccc actcctcttc ttggagaaca cagaggctcc cgcctcgccc 1080cagggcagca gctcagcctc actggttgag acagaggacc cttcacttga agacacaagc 1140gtgccttctg tccctcttgg ctcccgacag tgcttcctgt accctgggcc tggtggcagc 1200tatggcttcc gactcagttg tgtggccagt gggcctcgtc tcttcatctc ccaggtgact 1260ccaggaggct cagctgcccg ggctgggctg caagtgggag acgtgattct ggaagtgaac 1320gggtatcctg ttgggggaca gaatgacctg gagaggcttc agcagctgcc tgaggctgag 1380ccacccctct gcctgaagct ggcagccagg tctctgcggg gcttggaagc ctggattccc 1440cctggggctg cagaggactg ggctctggcc tcggatctac tgtagagcac ccctgcttgg 1500tacagacata ctcaggggct accgtgtctt cactctccag cctgaggtgg tgaaggcagg 1560atgctctctc taagccagac cagagggact cagacaccac cgatcacagg ctggcccagg 1620tgctccctcc cttcctgcag gcccacctgc cagcagaggg tgtggttgga ggcctcagac 1680aggtccctga aggagtctga ggctccagag gatgtcatat gggagtttta gagagctgtg 1740tcccaaggat gaaggtgtgg ctgtgggtct ggctaggatt gaagccatct ggaccttttc 1800tagatatgac tccaggaccc ttgagtgtaa tgcaaaaatt tggagaccag ctatgcctgc 1860cctctgtggg tgccttagca ttgcgggagg gtggtgcttg gtcaccgttg catttgttat 1920agaaatggcc attcgccata aatctgactg cctgtgtttg tgttggtggg ggtaaggggc 1980agtggtgtga agggaccaaa agggcctcag gctcaagggg tgggatgcgg ctcctgcagg 2040agagaggttg agacctggtc aaatttattt cctatcaatc actgaatctc agggataatg 2100ggtcaaccca gaactgagat gtctgtatga cagccactcc taaaaataaa caacaacaaa 2160aacaaaaaaa gaagaaaact aaataaaaat aaaaataaaa ataaaaaaaa aaaaaaaaaa 2220aaaaaaaaaa aaaaaaaaaa aaaaaa2246<210>60<211>2418<212>DNA<213>人
<400>60agtccagctt gggtccctga gagctgtgag aaggagatgc ggctgctgct ggccctgttg 60ggggtcctgc tgagtgtgcc tgggcctcca gtcttgtccc tggaggcctc tgaggaagtg120gagcttgagc cctgcctggc tcccagcctg gagcagcaag agcaggagct gacagtagcc180cttgggcagc ctgtgcggct gtgctgtggg cgggctgagc gtggtggcca ctggtacaag240gagggcagtc gcctggcacc tgctggccgt gtacggggct ggaggggccg cctagagatt300gccagcttcc tacctgagga tgctggccgc tacctctgcc tggcacgagg ctccatgatc360gtcctgcaga atctcacctt gattacaggt gactcctcga cctccagcaa cgatgatgag420gaccccaagt cccataggga cctctcgaat aggcacagtt acccccagca agcaccctac480tggacacacc cccagcgcat ggagaagaaa ctgcatgcag tacctgcggg gaacaccgtc540aagttccgct gtccagctgc aggcaacccc acgcccacca tccgctggct taaggatgga600caggcctttc atggggggaa ccgcattgga ggcattcggc tgcgccatca gcactggagt660ctcgtgatgg agagcgtggt gccctcggac cgcggcacat acacctgcct ggtagagaac720gctgtgggca gcatccgtta taactacctg ctagatgtgc tggagcggtc cccgcaccgg780cccatcctgc aggccgggct cccggccaac accacagccg tggtgggcag cgacgtggag840ctgctgtgca aggtgtacag cgatgcccag ccccacatcc agtggctgaa gcacatcgtc900atcaacggca gcagcttcgg agccgacggt ttcccctatg tgcaagtcct aaagactgca960gacatcaata gctcagaggt ggaggtcctg tacctgcgga acgtgtcagc cgaggacgca 1020ggcgagtaca cctgcctcgc aggcaattcc atcggcctct cctaccagtc tgcctggctc 1080acggtgctgc caggtactgg gcgcatcccc cacctcacat gtgacagcct gactccagca 1140ggcagaacca agtctcccac tttgcagttc tccctggagt caggctcctc cggcaagtca 1200agctcatccc tggtacgagg cgtgcgtctc tcctccagcg gccccgcctt gctcgccggc 1260ctcgtgagtc tagatctacc tctcgaccca ctatgggagt tcccccggga caggctggtg 1320cttgggaagc ccctaggcga gggctgcttt ggccaggtag tacgtgcaga ggcctttggc 1380atggaccctg cccggcctga ccaagccagc actgtggccg tcaagatgct caaagacaac 1440gcctctgaca aggacctggc cgacctggtc tcggagatgg aggtgatgaa gctgatcggc 1500cgacacaaga acatcatcaa cctgcttggt gtctgcaccc aggaagggcc cctgtacgtg 1560atcgtggagt gcgccgccaa gggaaacctg cgggagttcc tgcgggcccg gcgcccccca 1620ggccccgacc tcagccccga cggtcctcgg agcagtgagg ggccgctctc cttcccagtc 1680
ctggtctcct gcgcctacca ggtggcccga ggcatgcagt atctggagtc ccggaagtgt 1740atccaccggg acctggctgc ccgcaatgtg ctggtgactg aggacaatgt gatgaagatt 1800gctgactttg ggctggcccg cggcgtccac cacattgact actataagaa aaccagcaac 1860ggccgcctgc ctgtgaagtg gatggcgccc gaggccttgt ttgaccgggt gtacacacac 1920cagagtgacg tgtggtcttt tgggatcctg ctatgggaga tcttcaccct cgggggctcc 1980ccgtatcctg gcatcccggt ggaggagctg ttctcgctgc tgcgggaggg acatcggatg 2040gaccgacccc cacactgccc cccagagctg tacgggctga tgcgtgagtg ctggcacgca 2100gcgccctccc agaggcctac cttcaagcag ctggtggagg cgctggacaa ggtcctgctg 2160gccgtctctg aggagtacct cgacctccgc ctgaccttcg gaccctattc cccctctggt 2220ggggacgcca gcagcacctg ctcctccagc gattctgtct tcagccacga ccccctgcca 2280ttgggatcca gctccttccc cttcgggtct ggggtgcaga catgagcaag gctcaaggct 2340gtgcaggcac ataggctggt ggccttgggc cttggggctc agccacagcc tgacacagtg 2400ctcgaccttg atagcatg 2418<210>61<211>1944<212>DNA<213>人<400>61ccctctcgcg ccccaggccg gtgtaccccc gcactccgcg ccccggccta gaagctctct 60ctccccgctc cccggcccgg cccccgcccc gccccgcccc agcccgctgg gccgccatgg120agcgctggcc ttggccgtcg ggcggcgcct ggctgctcgt ggctgcccgc gcgctgctgc180agctgctgcg ctcagacctg cgtctgggcc gcccgctgct ggcggcgctg gcgctgctgg240ccgcgctcga ctggctgtgc cagcgcctgc tgcccccgcc ggccgcactc gccgtgctgg300ccgccgccgg ctggatcgcg ttgtcccgcc tggcgcgccc gcagcgcctg ccggtggcca360ctcgcgcggt gctcatcacc ggctgtgact ctggttttgg caaggagacg gccaagaaac420tggactccat gggcttcacg gtgctggcca ccgtattgga gttgaacagc cccggtgcca480tcgagctgcg tacctgctgc tcccctcgcc taaggctgct gcagatggac ctgaccaaac540caggagacat tagccgcgtg ctagagttca ccaaggccca caccaccagc accggcctgt600ggggcctcgt caacaacgca ggccacaatg aagtagttgc tgatgcggag ctgtctccag660tggccacttt ccgtagctgc atggaggtga atttctttgg cgcgctcgag ctgaccaagg720
gcctcctgcc cctgctgcgc agctcaaggg gccgcatcgt gactgtgggg agcccagcgg780gggacatgcc atatccgtgc ttgggggcct atggaacctc caaagcggcc gtggcgctac840tcatggacac attcagctgt gaactccttc cctggggggt caaggtcagc atcatccagc900ctggctgctt caagacagag tcagtgagaa acgtgggtca gtgggaaaag cgcaagcaat960tgctgctggc caacctgcct caagagctgc tgcaggccta cggcaaggac tacatcgagc 1020acttgcatgg gcagttcctg cactcgctac gcctggccat gtccgacctc accccagttg 1080tagatgccat cacagatgcg ctgctggcag ctcggccccg ccgccgctat taccccggcc 1140agggcctggg gctcatgtac ttcatccact actacctgcc tgaaggcctg cggcgccgct 1200tcctgcaggc cttcttcatc agtcactgtc tgcctcgagc actgcagcct ggccagcctg 1260gcactacccc accacaggac gcagcccagg gcccaaacct gagccccggc ccttccccag 1320cagtggctcg gtgagccatg tgcacctatg gcccagccac tgcagcacag gaggctccgt 1380gagcccttgg ttcctccccg aaaaccccca gcattacgat cccccaagtg tcctggaccc 1440tggcctaaag aatcccaccc ccacttcatg cccactgccg atgcccaatc caggcccggt 1500gaggccaagg tttcccagtg agcctctgcg cctctccact gtttcatgag cccaaacacc 1560ctcctggcac aacgctctac cctgcagctt ggagaactcc gctggatggg gagtctcatg 1620caagacttca ctgcagcctt tcacaggact ctgcagatag tgcctctgca aactaaggag 1680tgactaggtg ggttggggac cccctcagga ttgtttctcg gcaccagtgc ctcagtgctg 1740caattgaggg ctaaatccca agtgtctctt gactggctca agaattaggg ccccaactac 1800acacccccaa gccacaggga agcatgtact gtacttccca attgccacat tttaaataaa 1860gacaaatttt tatttcttct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1920aaaaaaaaaa aaaaaaaaaa aaaa 1944<210>62<211>661<212>DNA<213>人<400>62tttttttttt tttaaaatca atacaaatct tttattaaag atctactcat accatggctg 60aaatcatcta ttattgttgc tagttagcct ctcttctata gttgggtaat gttgtcttgc120cactgtgttt gccatctctc ccaagtgaaa agaacacttt ttaaaaaaaa ttaattgctc180caagttttca ggcccagggg aggctctccc attctcctcc ttcaataagt cccgtccagg240
aaagggtgat cttgtggata aattcatcat acttcacttt gccattgggt tcgatatctg300cttccctgaa gagatcatcc acttccttgt gggtgagctt ctcccccaga ctcgtgagtt360ttgaccgcag gtcggacgcc atgacgtaac ctttcttctc cttgtccacc atcaacatgg420ctagaagaat ttctttcttt gggtcttctt gttttatttg catgtgcata atggtcagaa480aagtggagaa atccagctct ccatttccgt ctatcccgtg ggtctgcagg tgccgctgca540cctcccctgg cgttgggctg gcccccaggc acctcatggc caccatgagg tcgggggctt600tatcttcccc ctctgctgct gtcatacaag gagaagcatt tcttgtctca ttaatttggt660c661<210>63<211>532<212>DNA<213>人<220>
<221>misc_feature<222>(519)..(519)<223>N EQUALS ANY KIND OF BASE<400>63taactatgga aaaccatgtt tatttttaat aaaggatgac atttccaatc agtaaaatat 60cataaaagta taaaaatgta ctaagtacaa tcattagcat tatgttatag gggaatagtg120gttataactt ttccctgtaa gatggcacat tggatggtca cagttggctt gatttacaga180ggggcaagag taggtgacca gttgtaccag ttgctccagt ttcctaggat ttgggactct240tgtaaaatga gaaagtccca ggcaaactgg gacggttggt cctacaagaa aaagagcagc300atcagagtgt tggctatagt ttggaactta ggaacaggat cagacattat tttttaactt360ctccacctat tttcccttta gctgtgaaat aaaaatccct tttgttatta ctgagggtgt420tacagctttc agaggctttt ttaccactgg gtttcatgta attttgactt aatacctatg480tcaagcctgg gaagaaaggc agttctaatc aacttgcang tgtggcattc tg532<210>64<211>1013<212>DNA<213>人<400>64atcattccta gaactgaagt tgaaaaggcc atcaggatgt cccggagccg tatcaatgat 60
gctttccgtc tgaatgacaa cagcctagag tttctgggga tacagccaac acttggacct120cctaaccagc cccctgtttc catatggctg attgtttttg gagttgtgat gggagtgata180gtggttggca ttgtcatcct gatcttcact gggatcagag atcggaagaa gaaaaataaa240gcaagaagtg gagaaaatcc ttatgcctcc atcgatatta gcaaaggaga aaataatcca300ggattccaaa acactgatga tgttcagacc tccttttaga aaaatctatg tttttcctct360tgaggtgatt ttgttgtatg taaatgttaa tttcatggta tagaaaatat aagatgataa420agatatcatt aaatgtcaaa actatgactc tgttcagaaa aaaaattgtc caaagacaac480atggccaagg agagagcatc ttcattgaca ttgctttcag tatttatttc tgtctctgga540tttgacttct gttctgtttc ttaataagga ttttgtatta gagtatatta gggaaagtgt600gtatttggtc tcacaggctg ttcagggata atctaaatgt aaatgtctgt tgaatttctg660aagttgaaaa caaggatata tcattggagc aagtgttgga tcttgtatgg aatatggatg720gatcacttgt agaggacatt gctttttcac ttccaaggtg cttgatcaac atctccctga780caacacaaaa ctagagccag gggcctccgt gaactcccag agcatgcctg atagaaactc840atttctactg ttctctaact gtggagtgaa tggaaattcc aactgtatgt tcaccctctg900aagtgggtac ccagtctctt aaatcttttg tatttgctca cagtgtttga gcagtgctga960gcacaaagca gacactcaat aaatgctaga tttacacaaa aaaaaaaaaa aaa 1013<210>65<211>2060<212>DNA<213>人<400>65tgttcccagc actcaagcct tgccaccgcc gagccgggct tcctgggtgt ttcaggcaag 60gaagtctagg tccctggggg gtgaccccca aggaaaaggc agcctccctg cgcacccggt120tgcccggagc cctctccagg gccggctggg ctgggggttg ccctggccag caggggcccg180ggggcgatgc cacccggtgc cgactgaggc caccgcacca tggcccgctc gctgacctgg240cgctgctgcc cctggtgcct gacggaggat gagaaggccg ccgcccgggt ggaccaggag300atcaacagga tcctcttgga gcagaagaag caggaccgcg gggagctgaa gctgctgctt360ttgggcccag gcgagagcgg gaagagcacc ttcatcaagc agatgcggat catccacggc420gccggctact cggaggagga gcgcaagggc ttccggcccc tggtctacca gaacatcttc480gtgtccatgc gggccatgat cgaggccatg gagcggctgc agattccatt cagcaggccc540
gagagcaagc accacgctag cctggtcatg agccaggacc cctataaagt gaccacgttt600gagaagcgct acgctgcggc catgcagtgg ctgtggaggg atgccggcat ccgggcctgc660tatgagcgtc ggcgggaatt ccacctgctc gattcagccg tgtactacct gtcccacctg720gagcgcatca ccgaggaggg ctacgtcccc acagctcagg acgtgctccg cagccgcatg780cccaccactg gcatcaacga gtactgcttc tccgtgcaga aaaccaacct gcggatcgtg840gacgtcgggg gccagaagtc agagcgtaag aaatggatcc attgtttcga gaacgtgatc900gccctcatct acctggcctc actgagtgaa tacgaccagt gcctggagga gaacaaccag960gagaaccgca tgaaggagag cctcgcattg tttgggacta tcctggaact accctggttc 1020aaaagcacat ccgtcatcct ctttctcaac aaaaccgaca tcctggagga gaaaatcccc 1080acctcccacc tggctaccta tttccccagt ttccagggcc ctaagcagga tgctgaggca 1140gccaagaggt tcatcctgga catgtacacg aggatgtaca ccgggtgcgt ggacggcccc 1200gagggcagca agaagggcgc acgatcccga cgccttttca gccactacac atgtgccaca 1260gacacacaga acatccgcaa ggtcttcaag gacgtgcggg actcggtgct cgcccgctac 1320ctggacgaga tcaacctgct gtgacccagg ccccacctgg ggcaggcggc accggcgggc 1380gggtgggagg tgggagtggc tgcagggacc ctagtgtcct ggtctatctc tccagcctcg 1440gcccacacgc aagggagtcg ggggacggcc cgctgctggc cgctctcttc tctgcctctc 1500accaggacag ccgcccccca gggtactcct gcccttgctt gactcagttt ccctcctttg 1560aaagggaagg agcaaaacgg ccatttggga tgccagggtg gatgaaaagg tgaagaaatc 1620aggggattga gacttgggtg ggtgggcatc tctcaggagc cccatctccg ggcgtgtcac 1680ctcctgggca gggttctggg accctctgtg ggtgacgcac accctgggat ggggctagta 1740gagccttcag gcgccttcgg gcgtggactc tggcgcactc tagtggacag gagaaggaac 1800gccttccagg aacctgtgga ctaggggtgc agggacttcc ctttgcaagg ggtaacagac 1860cgctggaaaa cactgtcact ttcagagctc ggtggctcac agagtgtcct gccccggttt 1920gcggacgaga gaaatcgcgg cccacaagca tcccccatcc cttgcaggct gggggctggg 1980catgctgcat cttaaccttt tgtatttatt ccctcacctt ctgcagggct ccgtgcgggc 2040tgaaattaaa gatttcttag 2060<210>66<211>7265<212>DNA<213>人
<400>66catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc 60acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag120gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt180tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa240cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag300tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga360tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc420cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga480gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt540cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc600atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta660accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat720cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa780ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact840tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg900cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat960tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta 1020cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg 1080gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa 1140aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct 1200tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc 1260aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg 1320cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga 1380acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc 1440ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc 1500tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa 1560ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg 1620ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg 1680
gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg 1740ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg 1800ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta 1860ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg 1920gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc 1980aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca 2040aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga 2100gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt 2160tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac 2220cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct 2280cagcctcaga gtcagatgca ggatacaagg cagatccaac catccccacc gtggtcctac 2340gatcagtcct accaatacct gggatccatt gcctctcctt ctgtgcaccc agcaacgccc 2400atttcacctg gacgtgccag cggcatgaca accctctctg cagaactttc cagtcgactc 2460tcaacggcac ccgacctgac agcgttcagc gacccgcgcc agttccccgc gctgccctcc 2520atctccgacc cccgcatgca ctatccaggc gccttcacct actccccgac gccggtcacc 2580tcgggcatcg gcatcggcat gtcggccatg ggctcggcca cgcgctacca cacctacctg 2640ccgccgccct accccggctc gtcgcaagcg cagggaggcc cgttccaagc cagctcgccc 2700tcctaccacc tgtactacgg cgcctcggcc ggctcctacc agttctccat ggtgggcggc 2760gagcgctcgc cgccgcgcat cctgccgccc tgcaccaacg cctccaccgg ctccgcgctg 2820ctcaacccca gcctcccgaa ccagagcgac gtggtggagg ccgagggcag ccacagcaac 2880tcccccacca acatggcgcc ctccgcgcgc ctggaggagg ccgtgtggag gccctactga 2940ggcgccaggc ctggcccggc tgggccacgc gggccgccgc cttcgcctcc gggcgcgcgg 3000gcctcctgtt cgcgacaagc ccgccgggat cccgggccct gggcccggcc accgtcctgg 3060ggccgagggc gcccgacggc caggatctcg ctgtaggtca ggcccgcgca gcctcctgcg 3120cccagaagcc cacgccgccg ccgtctgctg gcgccccggc cctcgcggag gtgtccgagg 3180cgacgcacct cgagggtgtc cgccggcccc agcacccagg ggacgcgctg gaaagcaaac 3240aggaagattc ccggagggaa actgtgaatg cttctgattt agcaatgctg tgaataaaaa 3300gaaagatttt atacccttga cttaactttt taaccaagtt gtttattcca aagagtgtgg 3360
aattttggtt ggggtggggg gagaggaggg atgcaactcg ccctgtttgg catctaattc 3420ttatttttaa tttttccgca ccttatcaat tgcaaaatgc gtatttgcat ttgggtggtt 3480tttattttta tatacgttta tataaatata tataaattga gcttgcttct ttcttgcttt 3540gaccatggaa agaaatatga ttcccttttc tttaagtttt atttaacttt tcttttggac 3600ttttgggtag ttgttttttt ttgttttgtt ttgttttttt gagaaacagc tacagctttg 3660ggtcattttt aactactgta ttcccacaag gaatccccag atatttatgt atcttgatgt 3720tcagacattt atgtgttgat aattttttaa ttatttaaat gtacttatat taagaaaaat 3780atcaagtact acattttctt ttgttcttga tagtagccaa agttaaatgt atcacattga 3840agaaggctag aaaaaaagaa tgagtaatgt gatcgcttgg ttatccagaa gtattgttta 3900cattaaactc cctttcatgt taatcaaaca agtgagtagc tcacgcagca acgtttttaa 3960taggattttt agacactgag ggtcactcca aggatcagaa gtatggaatt ttctgccagg 4020ctcaacaagg gtctcatatc taacttcctc cttaaaacag agaaggtcaa tctagttcca 4080gagggttgag gcgggtgcca ataattacat ctttggagag gatttgattt ctgcccaggg 4140atttgctcac cccaaggtca tctgataatt tcacagatgc tgtgtaacag aacacagcca 4200aagtaaactg tgtaggggag ccacatttac ataggaacca aatcaatgaa tttaggggtt 4260acgattatag caatttaagg gccaccagaa gcaggcctcg aggagtcaat ttgcctctgt 4320gtgcctcagt ggagacaagt gggaaaacat ggtcccacct gtgcgagacc ccctgtcctg 4380tgctgctcac tcaacaacat ctttgtgttg ctttcaccag gctgagaccc taccctatgg 4440ggtatatggg cttttacctg tgcaccagtg tgacaggaaa gattcatgtc actactgtcc 4500gtggctacaa ttcaaaggta tccaatgtcg ctgtaaattt tatggcacta tttttattgg 4560aggatttggt cagaatgcag ttgttgtaca actcataaat actaactgct gattttgaca 4620catgtgtgct ccaaatgatc tggtggttat ttaacgtacc tcttaaaatt cgttgaaacg 4680atttcaggtc aactctgaag agtatttgaa agcaggactt cagaacagtg tttgattttt 4740attttataaa tttaagcatt caaattaggc aaatctttgg ctgcaggcag caaaaacagc 4800tggacttatt taaaacaact tgtttttgag ttttcttata tatatattga ttatttgttt 4860tacacacatg cagtagcact ttggtaagag ttaaagagta aagcagctta tgttgtcagg 4920tcgttcttat ctagagaaga gctatagcag atctcggaca aactcagaat atattcactt 4980tcatttttga caggattccc tccacaactc agtttcatat attattccgt attacatttt 5040tgcagctaaa ttaccataaa atgtcagcaa atgtaaaaat ttaatttctg aaaagcacca 5100
ttagcccatt tcccccaaat taaacgtaaa tgtttttttt cagcacatgt taccatgtct 5160gacctgcaaa aatgctggag aaaaatgaag gaaaaaatta tgtttttcag tttaattctg 5220ttaactgaag atattccaac tcaaaaccag cctcatgctc tgattagata atcttttaca 5280ttgaaccttt actctcaaag ccatgtgtgg agggggcttg tcactattgt aggctcactg 5340gattggtcat ttagagtttc acagactctt accagcatat atagtattta attgtttcaa 5400aaaaaatcaa actgtagttg ttttggcgat aggtctcacg caacacattt ttgtatgtgt 5460gtgtgtgtgc gtgtgtgtgt gtgtgtgtga aaaattgcat tcattgactt caggtagatt 5520aaggtatctt tttattcatt gccctcagga aagttaaggt atcaatgaga cccttaagcc 5580aatcatgtaa taactgcatg tgtctggtcc aggagaagta ttgaataagc catttctact 5640gcttactcat gtccctattt atgatttcaa catggataca tatttcagtt ctttcttttt 5700ctcactatct gaaaatacat ttccctccct ctcttccccc caatatctcc ctttttttct 5760ctcttcctct atcttccaaa ccccactttc tccctcctcc ttttcctgtg ttctcttaag 5820cagatagcac atacccccac ccagtaccaa atttcagaac acaagaaggt ccagttcttc 5880ccccttcaca taaaggaaca tggtttgtca gcctttctcc tgtttatggg tttcttccag 5940cagaacagag acattgccaa ccatattgga tctgcttgct gtccaaacca gcaaacttcc 6000tgggcaaatc acaatcagtg agtaaataga cagcctttct gctgccttgg gtttctgtgc 6060agataaacag aaatgctctg attagaaagg aaatgaatgg ttccactcaa atgtcctgca 6120atttaggatt gcagatttct gccttgaaat acctgtttct ttgggacatt ccgtcctgat 6180gatttttatt tttgttggtt tttatttttg gggggaatga catgtttggg tcttttatac 6240atgaaaattt gtttgacaat aatctcacaa aacatatttt acatctgaac aaaatgcctt 6300tttgtttacc gtagcgtata catttgtttt gggatttttg tgtgtttgtt gggaattttg 6360tttttagcca ggtcagtatt gatgaggctg atcatttggc tctttttttc cttccagaag 6420agttgcatca acaaagttaa ttgtatttat gtatgtaaat agattttaag cttcattata 6480aaatattgtt aatgcctata actttttttc aatttttttg tgtgtgtttc taaggacttt 6540ttcttaggtt tgctaaatac tgtagggaaa aaatgcttct ttctaacttt gtttatttta 6600gactttaaaa tgagctactt cttattcact tttgtaaaca gctaatagca tggttccaat 6660tttttttaag ttcacttttt ttgttctagg ggaaatgaat gtgcaaaaaa agaaaaagaa 6720ctgttggtta tttgtgttat tctggatgta taaaaatcaa tggaaaaaaa taaactttca 6780
aattgaaatg acggtataac acatctactg aaaaagcaac gggaaatgtg gtcctattta 6840agccagcccc cacctagggt ctatttgtgt ggcagttatt gggtttggtc acaaaacatc 6900ctgaaaattc gtgcgtgggc ttctttctcc ctggtacaaa cgtatggaat gcttcttaaa 6960ggggaactgt caagctggtg tcttcagcca gatgacatga gagaatatcc cagaaccctc 7020tctccaaggt gtttctagat agcacaggag agcaggcact gcactgtcca cagtccacgg 7080tacacagtcg ggtgggccgc ctcccctctc ctgggagcat tcgtcgtgcc cagcctgagc 7140agggcagctg gactgctgct gttcaggagc caccagagcc ttcctctctt tgtaccacag 7200tttcttctgt aaatccagtg ttacaatcag tgtgaatggc aaataaacag tttgacaagt 7260acata 7265<210>67<211>4221<212>DNA<213>人<400>67gtcggccgtc ccctttaatt tttaaataca cggtcccctc ttttctctgg ggggggcaag 60caagaaatca aagaaggagg agacaagccg tcaattttct ccaaaacaaa ccccaccggg120caatttggtc tcggggtagg gggagacggg gtgattgcaa attattccag gacgagatcc180agttctccag cgggaaaggg gcaaaggaac gccgcgcgtt ggaagggcca gggtacgcag240ctccccttgc agcgcccgca ggacccccgc aagctcgtgc cggcgaaatc ggagaccgcc300gatctgtcct cgttctctcc tgcacgtctg gctgcattcg gaggaagacc tggggcgcga360gcgagcggcg acagcatgag cctgtgctga cctccgcgcg gcgggccgag cccagggctt420tgtcgcggta cctgcgccca gcccgcgccg caactctgtg cccagctttt gcaatctttt480gttgcagcgc tgaccgcacc aagttaaatg ctcccttgca atttttcttt tttttgtttg540tttgtttaat ttttggagag ctcgcgatct tggaaaagcc tcagacgcca tctacagtta600aaacgtaggt aactgccctc tcccgcaccc cccccttaca cgccccccac cctttccacc660aaaaaaaggg ggtgcagcgc ggattctggc tgccgtgcgt cgccagccgg tagacccgtg720cttgtttcct ttctcttttt gtttggcttc taacgcgttg ggactgagtc gccgccgtga780gctccccgaa gactgcacaa actaccgcgg gctcctccgc cccgtctgcg attcggaagc840cggcctgggg gtcgcgtcgg gagccctgcg ctgcagctcc gcaccttagc agcccgggta900ctcatccaga tccacgccgg ggacacacac acagagtaac taaaagtgcg gcgattctgc960
acatcgccga ctgctttggg gtaacaaaaa gacccgagtt gcctgccgac cgaggacccc 1020cgggagccgg gctcggagca gacgaggtat ccggcggcgc ccatttgggg gcttctaact 1080ctttctccac gcagcccctc ttctgtcccc tcccctctcg ctccctttta aaatcagtgg 1140caccgaggcg cctgcagccg cactcgccag cgactcatct ctccagcggg tttttttttg 1200tttgtcgtgt gcgatcctca cactcatgaa catacacagg tctaccccca tcacaatagc 1260gagatatggg agatcgcgga acaaaaccca ggatttcgaa gagttgtcgt ctataaggtc 1320cgcggagccc agccagagtt tcagcccgaa cctcggctcc ccgagcccgc ccgagactcc 1380gaacttgtcg cattgcgttt cttgtatcgg gaaatactta ttgttggaac ctctggaggg 1440agaccacgtt tttcgtgccg tgcatctgca cagcggagag gagctggtgt gcaaggtgtt 1500tgatatcagc tgctaccagg aatccctggc accgtgcttt tgcctgtctg ctcatagtaa 1560catcaaccaa atcactgaaa ttatcctggg tgagaccaaa gcctatgtgt tctttgagcg 1620aagctatggg gacatgcatt ccttcgtccg cacctgcaag aagctgagag aggaggaggc 1680agccagactg ttctaccaga ttgcctcggc agtggcccac tgccatgacg gggggctggt 1740gctgcgggac ctcaagctgc ggaaattcat ctttaaggac gaagagagga ctcgggtcaa 1800gctggaaagc ctggaagacg cctacattct gcggggagat gatgattccc tctccgacaa 1860gcatggctgc ccggcttacg taagcccaga gatcttgaac accagtggca gctactcggg 1920caaagcagcc gacgtgtgga gcctgggggt gatgctgtac accatgttgg tggggcggta 1980ccctttccat gacattgaac ccagctccct cttcagcaag atccggcgtg gccagttcaa 2040cattccagag actctgtcgc ccaaggccaa gtgcctcatc cgaagcattc tgcgtcggga 2100gccctcagag cggctgacct cgcaggaaat tctggaccat ccttggtttt ctacagattt 2160tagcgtctcg aattcagcat atggtgctaa ggaagtgtct gaccagctgg tgccggacgt 2220caacatggaa gagaacttgg accctttctt taactgagct catgccccac ggagacttag 2280caggttccag gagtgagcga gggcagcgga aaggagttct tccgggggac acgaattgcc 2340tggctgagta gcaagaaaga cacactctta agtttcttgg ttcagagcag gaaaaccttc 2400aaggagctga ctgaccacgt agcatggggg caagaggcgt gggatgggga ttggggtgag 2460atggatggga gcccgctgga gcttgtcttc cctaacatag cctgggagac caccccttgc 2520cacttgggcc acttccgcct accccacttt tcattttgtt ccaaaatagt tgcagatcct 2580gacagaatca aaactctctg cctcaaacac acatcctggc atcgcactgt tagcatttaa 2640cttcttgtta ggattcaggg aaggaacagt tggccaagaa ttttttttct tttaaacaag 2700
ccaaccacct agctggtaat taatgaggtt cacttaaaaa aaaaattcgg tgcacacaga 2760ctgacatgaa acctgggtgc tacagtaaaa gaaaacaaaa gtccagtttg tgtctcttaa 2820tcgctcactt caactcattt cttctaaata aactatttaa tatcctggtc aggaaatgac 2880atgttaatgc tttgctccct gaagggggaa aaaatctgtc ctttaacaag ctattctgtt 2940ttgtgtcaat tgggtccgtg gcaaggaagc tattaggaag tcaaacggtc caggatgcat 3000tacctgctaa tccttaggtt taaaggggga aagaaaaggg aagaagaaag gaaaagagaa 3060atccaactcc tttttcatgt tttgcttttg aacaatgagg gtttgtgtga caggcattcc 3120tctttgctga gatgatagca atggcctgag attttagcaa gctcctggag tctgatgctt 3180ttgcagtact ctgatcgcaa ctaaacattt gtctttgttt tattagaaac tagtgaaaca 3240aagcaggttg tcccacatgt ataaaataca gggcagctat ttagttttct ttacagagaa 3300tgatcctttt aaggcttgta aggccctctg gtttggacaa aaaccctcag tagagacaag 3360cgggaaggat aattagctga aagctatgat gatataaata aaaacagctc tctatcccaa 3420tacgcacctt tgtattttca agaactcttc tatttattaa ggaaaatgtc acattgtgat 3480gtattaagcc agtacttcaa ttacgggttg acttgggatg acatattaca tgctgtagtt 3540aacatttata attctttttc cttgtttgag tatttctgtc tctgaaataa ccttttactt 3600ggcttttcta gatagcttta tttgatttcg agtggcaaaa tgttttttat tacggctttt 3660ctattgctgt atgatacaga actcttttgg cataaatatt tgtgttccca gtacctcact 3720tgttcggatt tgactgcctg tatatgtttt gtgaaatggt cctgtttttg ggtaggtgac 3780acgtggactc tagtatgtaa atgttacttg aatctgtgct tcataatagt gtgtggcatg 3840tatgtgcaga ctcttggatg ctttatgcct gcgcaccagg agccctgtcc tcacgttccc 3900aggagggcgg cttcaccctt cgtaaccagg agacaaggcg gccatggatt tgcccttgat 3960tctattttgc taatggaaga tagaaaggag agaaggtttt tttttttttt taacattctg 4020aagatggtgc tgtgtcaaga aggacctttt ttttcccctc tcccctattt tttaagtacc 4080ttggaggagg agaggttggt gacatgcatg gtggggatct atggcctctg gtgctttgtc 4140ctgtatttgg tttaatgttt ttgtcctaat ctcttcaatc aataaaattg tgcgtattta 4200actaaaaaaa aaaaaaaaaa a 4221<210>68<211>524<212>DNA
<213>人<400>68ccctgccttc caccttggaa gaggaggctg gacgcatcag cagtggccag gcaggtcgca 60aaatctccca gcctagagac cacacctgaa acggctgaag ccagcttgca caagggctgc120tgtccctctg cggcaggcag agctggtggg ggcaggggtc acagagcagt catagacacc180atggaccagg caggagaagg gcagatggca catgggcaca acagggcctt gtccttagag240cactgggggg tcatggctgg gaggggcatg gcaggggctg gcatccctgt agagccagag300gggccaccca ggcagtgaca ttccagatat gttgggctca cctcatcctt gctgtgagac360tggagttcca tggggacatg aagtcagtac accgcagagc tgctcagctg ctctacctct420cgctgacttt tttgttgcac atatacattt tctttcaatt agcatttatt tcagctttta480tttaagcttt ttgacagtac atgtaaatat atgattataa ccat 524<210>69<211>4151<212>DNA<213>人<400>69gggaatagca gaataggagc aagccagcac tagtcagcta actaagtgac tcaaccaagg 60ccttttttcc ttgttatctt tgcagatact tcattttctt agcgtttctg gagattacaa120catcctgcgg ttccgtttct gggaacttta ctgatttatc tcccccctca cacaaataag180cattgattcc tgcatttctg aagatctcaa gatctggact actgttgaaa aaatttccag240tgaggctcac ttatgtctgt aaagatggga aaaaaataca agaacattgt tctactaaaa300ggattagagg tcatcaatga ttatcatttt agaatggtta agtccttact gagcaacgat360ttaaaactta atttaaaaat gagagaagag tatgacaaaa ttcagattgc tgacttgatg420gaagaaaagt tccgaggtga tgctggtttg ggcaaactaa taaaaatttt cgaagatata480ccaacgcttg aagacctggc tgaaactctt aaaaaagaaa agttaaaagt aaaaggacca540gccctatcaa gaaagaggaa gaaggaagtg catgctactt cacctgcacc ctccacaagc600agcactgtca aaactgaagg agcagaggca actcctggag ctcagaaaag aaaaaaatca660accaaagaaa aggctggacc caaagggagt aaggtgtccg aggaacagac tcagcctccc720tctcctgcag gagccggcat gtccacagcc atgggccgtt ccccatctcc caagacctca780ttgtcagctc cacccaacag ttcttcaact gagaacccga aaacagtggc caaatgtcag840gtaactccca gaagaaatgt tctccaaaaa cgcccagtga tagtgaaggt actgagtaca900
acaaagccat ttgaatatga gaccccagaa atggagaaaa aaataatgtt tcatgctaca960gtggctacac agacacagtt cttccatgtg aaggttttaa acaccagctt gaaggagaaa 1020ttcaatggaa agaaaatcat catcatatca gattatttgg aatatgatag tctcctagag 1080gtcaatgaag aatctactgt atctgaagct ggtcctaacc aaacgtttga ggttccaaat 1140aaaatcatca acagagcaaa ggaaactctg aagattgata ttcttcacaa acaagcttca 1200ggaaatattg tatatggggt atttatgcta cataagaaaa cagtaaatca gaagaccaca 1260atctacgaaa ttcaggatga tagaggaaaa atggatgtag tggggacagg acaatgtcac 1320aatatcccct gtgaagaagg agataagctc cagcttttct gctttcgact tagaaaaaag 1380aaccagatgt caaaactgat ttcagaaatg catagtttta tccagataaa gaaaaaaaca 1440aacccgagaa acaatgaccc caagagcatg aagctacccc aggaacagcg tcagcttcca 1500tatccttcag aggccagcac aaccttccct gagagccatc ttcggactcc tcagatgcca 1560ccaacaactc catccagcag tttcttcacc aagaaaagtg aagacacaat ctccaaaatg 1620aatgacttca tgaggatgca gatactgaag gaagggagtc attttccagg accgttcatg 1680accagcatag gcccagctga gagccatccc cacactcctc agatgcctcc atcaacacca 1740agcagcagtt tcttaaccac gttgaaacca agactgaaga ctgaacctga agaagtttcc 1800atagaagaca gtgcccagag tgacctcaaa gaagtgatgg tgctgaacgc aacagaatca 1860tttgtatatg agcccaaaga gcagaagaaa atgtttcatg ccacagtggc aactgagaat 1920gaagtcttcc gagtgaaggt ttttaatatt gacctaaagg agaagttcac cccaaagaag 1980atcattgcca tagcaaatta tgtttgccgc aatgggttcc tggaggtata tcctttcaca 2040cttgtggctg atgtgaatgc tgaccgaaac atggagatcc caaaaggatt gattagaagt 2100gccagcgtaa ctcctaaaat caatcagctt tgctcacaaa ctaaaggaag ttttgtgaat 2160ggggtgtttg aggtacataa ggtaagccca caccattgtt ttataaaatt tctcctgcaa 2220cctccaattt ttaaagtctt aacttgtcaa ctggagtttg gtcaacttac tcaacacaga 2280aaatcaaccc cttcaccctt cccccagcac tagagataat tgaatagagt tcatttcagg 2340atatggggta cgttatattg taacattcct cttcttaagg tatcatcatg caagttattt 2400agacagtcac taggaaactt ggcattttat tagttttgat gatctattca gagccaccct 2460tgtccaggac agtgcagagt ttatatcaac acacatatcc ttaggatttt gtttctttga 2520gttcttctcc atctgtatca atgacaactt aatttaattg tgaataaaag agttgctctc 2580
ccaagcctga atcctgattg tgacaaccag agtaagaaat aaaatagact actctgcttt 2640agaatgcagc tatgtctaac agttagctag aattctgatc atttggactc caaagtttct 2700tgcctcttct cattcattaa ttcatcagga gactgtagag caactaactt ctgcattaaa 2760taataagaga aatacgaagc aaaaagacta aaaaagtcac gtagcttaac tgctcaattt 2820ataaatgggg caataaaatg caaaaaaaaa gaaaaaaagc ttggtgaatt cttaggctta 2880cagtgtgcct ttcagtctct acacatcatg taaatattat gcttagctga tttaacttct 2940tgtttgaagt actgtttcat actccattat acatgtcttc tagggtggct tacttttaat 3000tgtgctgttt tctctacact cagtttaaat gactgtacat atatatgtgg ttggagagtt 3060aatgaataat gagctacaaa ccagaacaat gtgactagat agataggatg atctagaatt 3120gagaactggc agattgggaa aagagtggct atatggagaa agaaagaaag tagttccata 3180ttgaaataac agtctactta atgaggaccg ttgcaacatt ctttctcaaa cttacaaagt 3240gccataaaaa gcctctattc tctgctcttg ggcaggtgtg aaagaaacct accaaattaa 3300tcagattttt ctgtatccag gctccttaaa aaatcccagc tgtgctgatg tggaaacagg 3360aagaattagg aaagtaatca attttttttc ctagaaaaaa tccagcagac aaagaacttc 3420aacaaaagag gctcaaggga ggagttgaaa ggcaggattc aaagaccaag tatcttaagc 3480tatttggtac ctgttattca ggacctacag ctctgtttac tctatcaaag accaaaagtt 3540tccagaaaca ccctgtattt ctcatagatt tgaaaattat tgatccagtt tcagaagata 3600agtgttaatt ttcttttgca gaaaaatgta aggggtgaat tcacttatta tgaaatacaa 3660gataatacag ggaagatgga agtggtggtg catggacgac tgaccacaat caactgtgag 3720gaaggagata aactgaaact cacctgcttt gaattggcac cgaaaagtgg gaataccggg 3780gagttgagat ctgtaattca tagtcacatc aaggtcatca agaccaggaa aaacaagaaa 3840gacatactca atcctgattc caagtatgga aacttcacca gactttttct tctaaaatct 3900ggatgtcatt gacgataatg tttatggaga taaggtctaa gtgcctaaaa aaatgtacat 3960atacctggtt gaaatacaac actatacata cacaccacca tatatactag ctgttaatcc 4020tatggaatgg ggtattggga gtgctttttt aatttttcat agtttttttt taataaaatg 4080gcatattttg catctacaac ttctataatt tgaaaaaata aataaacatt atcttttttg 4140tgaaaaaaaa a4151<210>70<211>741
<212>DNA<213>人<220>
<221>misc_feature<222>(492)..(492)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(652)..(652)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(696)..(696)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(707)..(707)<223>N EQUALS ANY KIND BASE<400>70tttgcttttg tttcttctgg tcccatcact gggacctaaa agaagctcac atgtggtctc 60tggaaatgct gaagctgtgg actgtagaca ttattttcag tccttgtcct ggtggctgca120taccagatgc tgctccttcc ctgtgtgtgg ccagctgtac acagtgacat gctcccaagg180ccgcggcaca ggcggtgatg ggaactcctc cccgggccag cctctcaggc tgcagcccca240cggcaccctg aggccctcat ctctgctcgg cagctaaaac atctccttct tcgatgctct300gcaactgcag cctctggctc acaagagttc tgctgcctcg gcggcccccg aagccgcccc360ccgggacagt ccgtgctgta accaagaccc ctggcaaagc ctcctcccca aataagttga420ttttggcttc ggcctcaatg gctttggcca agcttgctgc gtaactgtcc aaggacttgt480gtacttcagc tntcacatga agaatcgagt tcttggcagc ttctttgatt tgttccactt540catcctcaaa tgtcaccgag ctccttctct ttggtgggca agtgcagtga gaagggaggg600tgtcatcaga cgtgtgtcct caagcagcat catatctgtc cctgagtcct gngagcagct660gaaaccagtg tcccccgtgc tgctgctgtg ccccangggc tgtccgnctg ccatgagcgc720aatgagtgtg ggacaggccc c 741<210>71<211>755
<212>DNA<213>人<220>
<221>misc_feature<222>(643)..(643)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(741)..(741)<223>N EQUALS ANY KIND BASE<400>71tggtagtgaa tactttattt tgttgtaaac aagttagttt tgagggtatt tcctcgtggt 60cctcctgccg tcactcgtcc ccatgttcca atgatgctga tcaactgctt tattcagttt120cccatctttc ttcttgccca ggcatcgtag cctttctttt tttaaacaca tgatccctag180tactcatctt tggaggacaa aaggctttcc atatgttaga aaaatttgaa tctcatagta240ctcacaacaa tgagcagcat tgtaagttgt gatgcattca tttggattgg aacattctca300atcagtcctt ccactctaag taaatatttg tttctcacag aacacaaggc agttcaaaag360gcctcttggt taaggaatta tagggtgttg aatgggaaac atcatacaag cagtgaaaac420aaaaatcttt ccaggttgtc ggattttctc cttcttggtc ttataaaaag caactagaca480tctctaattt aaaaaataca tgcacatata tacaatagtg attggaatgt attcttatcc540aaaacattat agagtttatc tcagatatac tgagtactgt cactcagtct gtaaattacc600cccaagaagg tgggttgttt cctcattcct taaataaaaa cangatcgaa taacagacca660aaaagaagtt actaaatttt aacactgaca tccttgtgaa gagccagtct ttacaggcgt720ttgtaaagta gactgtgggg nagtgtacac taata 755<210>72<211>1894<212>DNA<213>人<400>72aggactcggg ccggagcgtg gccggacccc cacccgccga ggggcccagg gaggacgcgg 60cagagtcacg gtggcagcat tgagagttgg acacccgggt ccttgaagtg atctctaggc120cccagcccca aatccgccac cattccgtgc tgcggggaca ccatggctcc agaagaggac180gctggagggg aggccttagg gggcagtttc tgggaggctg gcaactacag gcgcacggta240
cagcgggtgg aggacgggca ccggctgtgc ggggacctgg tcagctgctt ccaggagcgc300gcccgcatcg agaaggctta tgcccagcag ttggctgact gggcccgaaa gtggaggggg360accgtggaga agggccccca gtatggcaca ctggagaagg cctggcatgc ctttttcacg420gcggctgagc ggctgagcgc gctgcacctg gaggtgcggg agaagctgca agggcaggac480agtgagcggg tgcgcgcctg gcagcggggg gctttccacc ggcctgtgct gggcggcttc540cgcgagagcc gggcggccga ggacggcttc cgcaaggccc agaagccctg gctgaagagg600ctgaaggagg ttgaggcttc caagaaaagc taccacgcag cccggaagga tgagaagacc660gcccagacga gggagagcca cgcaaaggca gacagcgccg tctcccagga gcagctgcgc720aaactgcagg aacgggtgga acgctgtgcc aaggaggccg agaagacaaa agctcagtat780gagcagacgc tggcagagct gcatcgctac actccacgct acatggagga catggaacag840gcctttgaga cctgccaggc cgccgagcgc cagcggcttc ttttcttcaa ggatatgctg900ctcaccttac accagcacct ggacctttcc agcagtgaga agttccatga actccaccgt960gacttgcacc agggcattga ggcagccagt gacgaagagg atctgcgctg gtggcgcagc 1020acccacgggc caggcatggc catgaactgg ccacagttcg aggagtggtc cttggacaca 1080cagaggacaa tcagccggaa agagaagggt ggccggagcc ctgatgaggt taccctgacc 1140agcattgtgc ctacaagaga tggcaccgca cccccacccc agtccccggg gtccccaggc 1200acggggcagg atgaggagtg gtcagatgaa gagagtcccc ggaaggctgc caccggggtt 1260cgggtgaggg cactctatga ctacgctggc caggaagctg atgagctgag cttccgagca 1320ggggaggagc tgctgaagat gagtgaggag gacgagcagg gctggtgcca aggccagttg 1380cagagtggcc gcattggcct gtaccctgcc aactacgtgg agtgtgtggg cgcctgagtg 1440tcctgacagc ccttctgcaa cgtttaccca ccctggttca gagcccagct tctcctggag 1500agccggaccc tcagggccct gaaccgtcgc tctctggctg ctcctctgtc ccttgaggga 1560ggaagtcctg ggacccaggg aggggagggg cctttgtcta gggaagggac tggtagggaa 1620gggacgagtc taggctgagg gcaagatggg aggtcagagg tgacagaagc gttcaggggt 1680gcctgggcct ccccaggagc tgtggactca gttcctgacc tctgctttgg ggttcctggg 1740gtgggcttgg ggtgagtgta gttctggcct agcagcaccc tcttgtggct tgttctagcg 1800tgtattaaaa cttgacacac acccacacac aaaaccaaaa aaaaaaaaaa aaaaaaaaaa 1860aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1894
<210>73<211>649<212>DNA<213>人<400>73ggcgaggcgt ctcggagtct cagagacacc aaggcccctg cgacaaggtg gctgcagcta 60ggccgggggc gtcaggacga cggagcgggt tcgggtcggt gacacgcaga cctgagggag 120ctgggcccgc cttttccgcc cgcgccccag gcccttgcag atcgagattt gcgtcctaga 180gtgggaaaaa agcagaggcc agggcgccga ttttatttgg agagaagcaa gcatctttgc 240ctctttggag taggaaattc agacttgaaa aagtggtgtg tggttgactc tgtttctcgc 300catgtcttct cacaagactt tcaccattaa gcgattcctg gccaagaaac aaaagcaaaa 360tcgtcccatc ccccagtgga ttcagatgaa acctggtagt aaaatcaggt acaactccaa 420aaggaggcat tggagaagaa ccaagctggg tctataagga attgcacatg agatggcaca 480catatttatg ctgtatcaag ttcacgatca tcttacgata tcaagctgaa aatgtcacca 540ctacctggac agttgcacat gttttactgg gaatattttt ttctgttttt ctgtatgctc 600tgtgctagta gggtggattc agtaataaat atgtgaaagc ttttgtttc 649<210>74<211>1561<212>DNA<213>人<400>74gcggcgcgga gggcgcgggc ccgggagcca gggagcgagc ggggcgcccg gcagcgcgga 60gtcagcgccg cgggggccgc acccgactcg cgcctggaca ctcgcggggc gccgacctgg 120cagggggcca aaccagtgct cctgccacct ctctggctgc cccctagagc ctgcccatcc 180cagcctgacc aatgtccaca gccagggagc agccaatctt cagcacacgg gcgcacgtgt 240tccaaattga cccagccacc aagcgaaact ggatcccagc gggcaagcac gcactcactg 300tctcctattt ctacgatgcc acccgcaatg tgtaccgcat catcagcatc ggaggcgcca 360aggccatcat caacagcact gtcactccca acatgacctt caccaaaact tcccagaagt 420tcgggcagtg ggccgacagt cgcgccaaca cagtctacgg cttgggcttt gcctctgaac 480agcatctgac acagtttgcc gagaagttcc aggaagtgaa ggaagcagcc aggctggcca 540gggagaaatc tcaggatggc ggggagctca ccagtccagc cctggggctc gcctcccacc 600aggtgccccc gagccctctc gtcagtgcca acggccccgg cgaggaaaaa ctgttccgca 660
gccagagcgc tgatgccccc ggccccacag agcgcgagcg gctaaagaag atgttgtctg720agggctccgt gggcgaggta cagtgggagg ccgagttttt cgcactgcag gacagcaaca780acaagctggc aggcgccctg cgagaggcca acgccgccgc agcccagtgg aggcagcagc840tggaggctca gcgtgcagag gccgagcggc tgcggcagcg ggtggctgag ctggaggctc900aggcagcttc agaggtgacc cccaccggtg agaaggaggg gctgggccag ggccagtcgc960tggaacagct ggaagctctg gtgcaaacca aggaccagga gattcagacc ctgaagagtc1020agactggggg gccccgcgag gccctggagg ctgccgagcg tgaggagact cagcagaagg1080tgcaggacct ggagacccgc aatgcggagt tggagcacca gctgcgggcg atggagcgca1140gcctggagga ggcacgggca gagcgggagc gggcgcgggc tgaggtgggc cgggcagcgc1200agctgctgga cgtcaggctg tttgagctga gtgagctgcg tgagggcctg gcccgcctgg1260ctgaggctgc gccctgagcc ggggctggtt ttctatgaac gattccggcc tgggatgcgg1320gccaggctgc aggcggcata gttgggccca ttcgtcctgg aaagggactg gggggtccca1380acttagccct gggtgggccg ggccgggctg ggctggggtg ggccccagtc ggctctggtt1440gttggcagct ttggggctgt ttttgagctt ctcattgtgt agaatttcta gatcccccga1500ttacatttct aagcgtgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa1560a1561<210>75<211>1188<212>DNA<213>人<400>75tcgagatcca ttgtgctcta aaggctcgcc ctcctgtgca tcgcggctaa tttggggtat 60cactgagctg aagacaaaga gaagggggag aaaacctagc agaccaccat gtgctatggg120aagtgtgcac gatgcatcgg acattctctg gtggggctcg ccctcctgtg catcgcggct180aatattttgc tttactttcc caatggggaa acaaagtatg cctccgaaaa ccacctcagc240cgcttcgtgt ggttcttttc tggcatcgta ggaggtggcc tgctgatgct cctgccagca300tttgtcttca ttgggctgga acaggatgac tgctgtggct gctgtggcca tgaaaactgt360ggcaaacgat gtgcgatgct ttcttctgta ttggctgctc tcattggaat tgcaggatct420ggctactgtg tcattgtggc agcccttggc ttagcagaag gaccactatg tcttgattcc480ctcggccagt ggaactacac ctttgccagc accgagggcc agtaccttct ggatacctcc540
acatggtccg agtgcactga acccaagcac attgtggaat ggaatgtatc tctgttttct600atcctcttgg ctcttggtgg aattgaattc atcttgtgtc ttattcaagt aataaatgga660gtgcttggag gcatatgtgg cttttgctgc tctcaccaac agcaatatga ctgctaaaag720aaccaaccca ggacagagcc acaatcttcc tctatttcat tgtaatttat atatttcact780tgtattcatt tgtaaaactt tgtattagtg taacatactc cccacagtct acttttacaa840acgcctgtaa agactggcat cttcacagga tgtcagtgtt taaatttagt aaacttcttt900tttgtttgtt tatttgtgta acatactccc cacagtctac ttttacaaac gcctgtaaag960actggcatct tcacaggatg tcagtgttta aatttagtaa acttcttttt tgtttgttta 1020tttgtttttg ttttttttta aggaatgagg aaacaaacca ccctctgggg gtagtttaca 1080gactgagtga cagtactcag tatatctgag ataaactcta taatgttttg gataaaaata 1140acattccatg gcacatatat acaatagtga ttggctttag agcacaat1188<210>76<211>1075<212>DNA<213>人<400>76cgcagcaaac acatccgtag aaggcagcgc ggccgccgag agccgcagcg ccgctcgccc 60gccgcccccc accccgccgc cccgcccggc gaattgcgcc ccgcgcccct cccctcgcgc120ccccgagaca aagaggagag aaagtttgcg cggccgagcg gggcaggtga ggagggtgag180ccgcgcggga ggggcccgcc tcggccccgg ctcagccccc gcccgcgccc ccagcccgcc240gccgcgagca gcgcccggac cccccagcgg cggcccccgc ccgcccagcc ccccggcccg300ccatgggcgc cgcggcccgc accctgcggc tggcgctcgg cctcctgctg ctggcgacgc360tgcttcgccc ggccgacgcc tgcagctgct ccccggtgca cccgcaacag gcgttttgca420atgcagatgt agtgatcagg gccaaagcgg tcagtgagaa ggaagtggac tctggaaacg480acatttatgg caaccctatc aagaggatcc agtatgagat caagcagata aagatgttca540aagggcctga gaaggatata gagtttatct acacggcccc ctcctcggca gtgtgtgggg600tctcgctgga cgttggagga aagaaggaat atctcattgc aggaaaggcc gagggggacg660gcaagatgca catcaccctc tgtgacttca tcgtgccctg ggacaccctg agcaccaccc720agaagaagag cctgaaccac aggtaccaga tgggctgcga gtgcaagatc acgcgctgcc780ccatgatccc gtgctacatc tcctccccgg acgagtgcct ctggatggac tgggtcacag840
agaagaacat caacgggcac caggccaagt tcttcgcctg catcaagaga agtgacggct900cctgtgcgtg gtaccgcggc gcggcgcccc ccaagcagga gtttctcgac atcgaggacc960cataagcagg cctccaacgc ccctgtggcc aactgcaaaa aaagcctcca agggtttcga 1020ctggtccagc tctgacatcc cttcctggaa acagcatgaa taaaacactc atccc1075<210>77<211>1358<212>DNA<213>人<400>77gcgacccggg gcgtttgcag cggtgccgag gaagaggacg ggaacggtgt tacgattgcc 60tgcgtttagg aggtggctgc gttgtgggaa aagctatcaa ggaagaaatt gccaaaccat120gtcttttttt ctgttttcag agtagttcac aacagatctg agtgttttaa ttaagcatgg180aatacagaaa acaacaaaaa acttaagctt taatttcatc tggaattcca cagttttctt240agctccctgg acccggttga cctgttggct cttcccgctg gctgctctat cacgtggtgc300tctccgacta ctcaccccga gtgtaaagaa ccttcggctc gcgtgcttct gagctgctgt360ggatggcctc ggctctctgg actgtccttc cgagtaggat gtcactgaga tccctcaaat420ggagcctcct gctgctgtca ctcctgagtt tctttgtgat gtggtacctc agccttcccc480actacaatgt gatagaacgc gtgaactgga tgtacttcta tgagtatgag ccgatttaca540gacaagactt tcacttcaca cttcgagagc attcaaactg ctctcatcaa aatccatttc600tggtcattct ggtgacctcc cacccttcag atgtgaaagc caggcaggcc attagagtta660cttggggtga aaaaaagtct tggtggggat atgaggttct tacatttttc ttattaggcc720aagaggctga aaaggaagac aaaatgttgg cattgtcctt agaggatgaa caccttcttt780atggtgacat aatccgacaa gattttttag acacatataa taacctgacc ttgaaaacca840ttatggcatt caggtgggta actgagtttt gccccaatgc caagtacgta atgaagacag900acactgatgt tttcatcaat actggcaatt tagtgaagta tcttttaaac ctaaaccact960cagagaagtt tttcacaggt tatcctctaa ttgataatta ttcctataga ggattttacc 1020aaaaaaccca tatttcttac caggagtatc ctttcaaggt gttccctcca tactgcagtg 1080ggttgggtta tataatgtcc agagatttgg tgccaaggat ctatgaaatg atgggtcacg 1140taaaacccat caagtttgaa gatgtttatg tcgggatctg tttgaattta ttaaaagtga 1200acattcatat tccagaagac acaaatcttt tctttctata tagaatccat ttggatgtct 1260
gtcaactgag acgtgtgatt gcagcccatg gcttttcttc caaggagatc atcacttttt 1320ggcaggtcat gctaaggaac accacatgcc attattaa 1358<210>78<211>1246<212>DNA<213>人<400>78ggaaaggcct tggaaagcag tcgttgcgcc agacagccca gggaagagcg gcagcctgag 60gacctagggc cacctgctgt tccctgggat tcatgtcctt ctggggagga gggaggaccc120aggacaatgg ctgctgttca tgatctggag atggagagca tgaatctgaa tatggggaga180gagatgaaag aagagctgga ggaagaggag aaaatgagag aggatggggg aggtaaagat240cgggccaaga gtaaaaaggt ccacaggatt gtctcaaaat ggatgctgcc cgaaaagtcc300cgaggaacat acttggagag agctaactgc ttcccgcctc ccgtgttcat catctccatc360agcctggccg agctggcagt gtttatttac tatgctgtgt ggaagcctca gaaacagtgg420atcacgttgg acacaggcat cttggagagt ccctttatct acagtcctga gaagagggag480gaagcctgga ggtttatctc atacatgctg gtacatgctg gagttcagca catcttgggg540aatctttgta tgcagcttgt tttgggtatt cccttggaaa tggtccacaa aggcctccgt600gtggggctgg tgtacctggc aggagtgatt gcagggtccc ttgccagctc catctttgac660ccactcagat atcttgtggg agcttcagga ggagtctatg ctctgatggg aggctatttt720atgaatgttc tggtgaattt tcaagaaatg attcctgcct ttggaatttt cagactgctg780atcatcatcc tgataattgt gttggacatg ggatttgctc tctatagaag gttctttgtt840cctgaagatg ggtctccggt gtcttttgca gctcacattg caggtggatt tgctggaatg900tccattggct acacggtgtt tagctgcttt gataaagcac tgctgaaaga tccaaggttt960tggatagcaa ttgctgcata tttagcttgt gtcttatttg ctgtgttttt caacattttc 1020ctatctccag caaactgacc tgcccctatt gtaagtcaat taataaaaag agccatctgg 1080aggaaataaa aaaaaaagga agactctatg aagaaacaga gaagtctcag aaaaggctaa 1140caattttata tagaggacaa aacagcatta aactcatcag ttgcaaagat tgcctataaa 1200aggaccttag gatttaagga aggggcttct taatgtagaa agggaa 1246<210>79<211>704<212>DNA
<213>人<220>
<221>misc_feature<222>(23)..(23)<223>N EQUALS ANY KIND BASE<400>79tttttttttt tttttttcag tantcagaat aatatatttt acttcttata atgtaaaaaa 60tataatcgtt tgagtggttt tcagcatgat ctgttaattt tgaatacaga gaatgaacaa120agcaggtaaa tatatgtata tgctgaataa tgtaattcca tatacaattc acagttagat180gcacttaatt gtggaaaata aaggaagaca ataacatcaa gatctttttc caaaacacgg240taaaaataac gttcacatgc attaaacatt tcaagccatc tcagtatatg tctttcttga300gtaagtagtg aaccaatgga ccagtggtta ttgttggaga aaacaattag gcaactcatc360aatgcgctat ttatacaatc ttagtgacta tttaccactt cacctaagta gactttccca420ctcatttgaa gctattgcta tctataaata aatggcaaca ggaaatgttt cacaagggcc480tttgatttcc aaaactctca aattccacag caaagactca atttaaggca attatttatg540cactgaatat ttgaatgaag atgtattatt ttccttaagt gaaaaaagct gatactattt600tgtaatgata aaatttgtat accatagtag aaaatgattt gcaattatgt gttaggactt660ttcatattcc atattgaaac atagtgattc tgtagctggg atca 704<210>80<211>1605<212>DNA<213>人<400>80atgggctgtg tgcaatgtaa ggataaagaa gcaacaaaac tgacggagga gagggacggc 60agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc120agcttcggtg tgacctccat ccccaactac aacaacttcc acgcagccgg gggccaagga180ctcaccgtct ttggaggtgt gaactcttcg tctcatacgg ggaccttgcg tacgagagga240ggaacaggag tgacactctt tgtggccctt tatgactatg aagcacggac agaagatgac300ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agattggtgg360gaagcccgct ccttgacaac tggagagaca ggttacattc ccagcaatta tgtggctcca420gttgactcta tccaggcaga agagtggtac tttggaaaac ttggccgaaa agatgctgag480cgacagctat tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagtgaaacc540
accaaaggtg cctattcact ttctatccgt gattgggatg atatgaaagg agaccatgtc600aaacattata aaattcgcaa acttgacaat ggtggatact acattaccac ccgggcccag660tttgaaacac ttcagcagct tgtacaacat tactcagaga aagctgacgg tttgtgtttt720aacttaactg tgattgcatc gagttgtacc ccacaaactt ctggattggc taaagatgct780tgggaagttg cacgtcgttc gttgtgtctg gagaagaagc tgggtcaggg gtgtttcgct840gaagtgtggc ttggtacctg gaatggaaac acaaaagtag ccataaagac tcttaaacca900ggcacaatgt cccccgaatc attccttgag gaagcgcaga tcatgaagaa gctgaagcac960gacaagctgg tccagctcta tgcagtggtg tctgaggagc ccatctacat cgtcaccgag 1020tatatgaaca aaggaagttt actggatttc ttaaaagatg gagaaggaag agctctgaaa 1080ttaccaaatc ttgtggacat ggcagcacag gtggctgcag gaatggctta catcgagcgc 1140atgaattata tccatagaga tctgcgatca gcaaacattc tagtggggaa tggactcata 1200tgcaagattg ctgacttcgg attggcccga ttgatagaag acaatgagta cacagcaaga 1260caaggtgcaa agttccccat caagtggacg gcccccgagc gagccctgta cgggaggttc 1320acaatcaagt ctgacgtgtg gtcttttgga atcttactca cagagctggt caccaaagga 1380agagtgccat acccaggcat gaacaaccgg gaggtgctgg agcaggtgga gcgaggctac 1440aggatgccct gcccgcagga ctgccccatc tctctgcatg agctcatgat ccactgctgg 1500aaaaaggacc ctgaagaacg ccccactttt gagtacttgc agagcttcct ggaagactac 1560tttaccgcga cagagcccca gtaccaacct ggtgaaaacc tgtaa 1605<210>81<211>1717<212>DNA<213>人<400>81ccggggacgg ctgctggagc ggcgcccgcc gcggctcagc gcattcccgc tctccgcttc 60cctctccgct gcgtccccgc gcgaagatgg caaccgaggg gctgcacgag aacgagacgc120tggcgtcgct gaagagcgag gccgagagcc tcaagggcaa gctggaggag gagcgagcca180agctgcacga tgtggagctg caccaggtgg cggagcgggt ggaggccctg gggcagtttg240tcatgaagac cagaaggacc ctcaaaggcc acgggaacaa agtcctgtgc atggactggt300gcaaagataa gaggaggatc gtgagctcgt cacaggatgg gaaggtgatc gtgtgggatt360ccttcaccac aaacaaggag cacgcggtca ccatgccctg cacgtgggtg atggcatgtg420
cttatgcccc atcgggatgt gccattgctt gtggtggttt ggataataag tgttctgtgt480accccttgac gtttgacaaa aatgaaaaca tggctgccaa aaagaagtct gttgctatgc540acaccaacta cctgtcggcc tgcagcttca ccaactctga catgcagatc ctgacagcga600gcggcgatgg cacatgtgcc ctgtgggacg tggagagcgg gcagctgctg cagagcttcc660acggacatgg ggctgacgtc ctctgcttgg acctggcccc ctcagaaact ggaaacacct720tcgtgtctgg gggatgtgac aagaaagcca tggtgtggga catgcgctcc ggccagtgcg780tgcaggcctt tgaaacacat gaatctgaca tcaacagtgt ccggtactac cccagtggag840atgcctttgc ttcagggtca gatgacgcta cgtgtcgcct ctatgacctg cgggcagata900gggaggttgc catctattcc aaagaaagca tcatatttgg agcatccagc gtggacttct960ccctcagtgg tcgcctgctg tttgctggat acaatgatta cactatcaac gtctgggatg 1020ttctcaaagg gtcccgggtc tccatcctgt ttggacatga aaaccgcgtt agcactctac 1080gagtttcccc cgatgggact gctttctgct ctggatcatg ggatcatacc ctcagagtct 1140gggcctaatc atcttctgac agtgcactca tgtatacctg agaatttgaa atcttcacat 1200gtaaatagat attacttcta gaggagctta gagtttattg cagtgtagct taggggagca 1260acccatggct cacaggtcac taagcgtctc caatatgact attaaaactg tcacctctgg 1320aaatacacta gtgtgagcct tcagcactgc gagaatacct tcaagtacag tatttttctt 1380ttggaacact ttttaaaatg tatctgtttt taaggttatt ctaaattata gtagcctcaa 1440ctcattctgt caccagtaga attcagcagt taatatattc catattattt ctttgaatca 1500attcattttc agagcacttt aaagtctgat atttctcgat gtgcactgtg atgcctggaa 1560ccttcctctg gaagtgctga ttttatggac tgaggactgg tgactggtct gtgatagaag 1620caaattccaa ttccaaatgt aattagacaa aaatcatttt tttagaatgt gtttttattg 1680taaaagtatc tttttcagca aaaaaaaaaa aaaaaaa1717<210>82<211>691<212>DNA<213>人<220>
<221>misc_feature<222>(281)..(281)<223>N EQUALS ANY KIND BASE
<220>
<221>misc_feature<222>(345)..(345)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(358)..(358)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(443)..(443)<223>N EQUALS ANY KIND BASE<220>
<221>misc_feature<222>(478)..(478)<223>N EQUALS ANY KIND BASE<400>82tttttttttt tttttagaac cttagcactt taatagaatt agagactttg gaatttcagg 60tccttagaac caaagactca cagcatcttt gaaacctaga acctttgaat ctagactctt 120taaaccttgg actctagagt cttggaatgt taacacctgg gagggcttca gatattgcaa 180tccaacccct tccttttaca gatggtgatg ctactgcttt caaggtgatg ctactgcaca 240gagaagggga gggacctgtc tgggatggag gtgggatagg ntagagacag ggctgcaagt 300ggggataagg cgtggtggga aagtgggaag ggggagtttc cccantggca gtgcttanct 360tggatcctga gagggagtac caggtggagg gttgtctcag gcaccatcct cctgccctgg 420ggctgctggg gagcccctat cancaggctg agcggggcta ggggttgtgg aagggcanag 480gacatagcgt tcagcaggat ggacctcaac cgcagtgagg cagctacagg aatccttagg 540gtctggctgg gtttgggggg tcagctcctt cttgagcttc cagggggtca aggtaacctc 600caccttattc atggtgacat agagggattc gtcggcttct gggcagggaa gcagggcttt 660agtggtgtct tcaaaacttc cccgagctct g 691<210>83<211>1284<212>DNA<213>人<400>83ggcctgtaca ttttcaagga attcttgaga ggttcttgga gagattctgg gagccaaaca 60
ctccattggg atcctagctg ttttagagaa caacttgtaa tggagccttc atctcttgag120ctgccggctg acacagtgca gcgcattgcg gctgaactca aatgccaccc aacggatgag180agggtggctc tccacctaga tgaggaagat aagctgaggc acttcaggga gtgcttttat240attcccaaaa tacaggatct gcctccagtt gatttatcat tagtgaataa agatgaaaat300gccatctatt tcttgggaaa ttctcttggc cttcaaccaa aaatggttaa aacatatctt360gaagaagaac tagataagtg ggccaaaata gcagcctatg gtcatgaagt ggggaagcgt420ccttggatta caggagatga gagtattgta ggccttatga aggacattgt aggagccaat480gagaaagaaa tagccctaat gaatgctttg actgtaaatt tacatcttct aatgttatca540ttttttaagc ctacgccaaa acgatataaa attcttctag aagccaaagc cttcccttct600gatcattatg ctattgagtc acaactacaa cttcacggac ttaacattga agaaagtatg660cggatgataa agccaagaga gggggaagaa accttaagaa tagaggatat ccttgaagta720attgagaagg aaggagactc aattgcagtg atcctgttca gtggggtgca tttttacact780ggacagcact ttaatattcc tgccatcaca aaagctggac aagcgaaggg ttgttatgtt840ggctttgatc tagcacatgc agttggaaat gttgaactct acttacatga ctggggagtt900gattttgcct gctggtgttc ctacaagtat ttaaatgcag gagcaggagg aattgctggt960gccttcattc atgaaaagca tgcccatacg attaaacctg cgagatcgga gttctttaat 1020taggaatgga atgcaacaga tttggacaag tcaaggacaa gagctttaga gagaccaaag 1080agtttttcac tgttaaagtg tccagtatgt agccgagaac catatggaga acatcaaata 1140cagtggaaca aatgtaactg ctattgatgt cacactttgt gaagtagtct ttgttgctta 1200aaaagggtga catctagtgg ctaaacatgt tatttcaaat aaataatatc gaaataaaaa 1260aaaaaaaaaa aaaaaaaaaa aaaa 1284<210>84<211>566<212>DNA<213>人<400>84ttttgggatg cttcactttc tttattgccc atccagggga cagccaagcc agctccatct 60gcattctggc tgcagcgtgt acattagggg actcaggggc cacagtgtgg gaccgtgcac120actggcaagg cactggcgga tgctggcagg ccagtggaca tggatagatg agaatgacaa180ctcacagatg tcctagcttc cgctggccca gctgccagcc actggccatc acccttttgc240
ccagcatgtg tgcattgtca cccaaaacat cttgaaactt gccattagtg aggcattcaa300caaagaagta agctaagtga gtaggaaaca gtgtttcctg gaatataccg cactctgcct360gaaataggaa aactatgttt gccgggaagc agcagcagca ggaaagaagt tataccaaaa420acgacttgta caccacagac attataaccc tttcctcaaa gaaacagtca tgttctgttg480ggtattatgg acaggtctct ggaaatttat ctaataaaga ccaacaaact tccccagcag540tgcctctgag taccgtgtga attctg 566<210>85<211>813<212>DNA<213>人<220>
<221>misc_feature<222>(688)..(688)<223>N EQUALS ANY KIND BASE<400>85tttttttttt tttttttttt tttttttttt ttaaacaaac aaaaaagaag tttactaaat 60ttaaacactg acatcctggg aagatgccag tctttacagg cgtttgtaaa agtaaactgg120ggggagtatg ttacactaat acaaagtttt acaaatgaat acaagtgaaa tatttaaatt180acaatgaaat agaggaagat tggggctttg tcctgggttg gtttttttag cagtcatatt240gctgttgggg agagcagcaa aagccacata tgcctccaag cactccattt attacttgaa300taagacacaa gatgaattca attccaccaa gagccaagag gatagaaaac agagatacat360tccattccac aatgtgcttg ggttcagtgc actcggacca tgtggaggta tccaaaaggg420tcttgccctt ggggcttgga aaaggggtat ttccactggc cgagggaatc aagacatagt480ggtccttctg ctaagccaag ggctgccaca atgacacagt agccagatcc tgcaattcca540atgagagcag ccaatacaga agaaagcatc gcacatcgtt tgccacagtt ttcatggcca600cagcagccac agcagtcatc ctgttccagc ccaatgaaaa caaatgctgg caggagcatc660agcaggccac cttctacgat gccagaanaa gaacacacga aagcgggttg aggggttttg720ggaggcattc tttgtttccc ccttggggaa ataaaagcaa attttaaccc gggatgcccc780aggaggcggg ccccaaccaa aaaaatgtcg gat 813<210>86<211>2328
<212>DNA<213>人<400>86gccagccgag cggccagcca gtgcggggct ggccatgtaa ggcccacagg cggtcctgcc 60cgcccggtgc cctgcggaga gcctcgtgca gccctgggca ccgcccctgc cctgccctga120ccccttggcc ttgaaatgct gtcatcggag gagccgtccc gctcgggaca aggccagcat180ggacaaagct agagctgggg caagcaagga gccttcctgt cctcgaggcc gtgggaagag240aagcacgccc agggggccac tcctgagagc ctctctgtcc accaggcctc tgcagagggg300tcaccatggc tctggcccga ggcagccggc agctgggggc cctggtgtgg ggcgcctgcc360tgtgcgtgct ggtgcacggg cagcaggcgc agcccgggca gggctcggac cccgcccgct420ggcggcagct gatccagtgg gagaacaacg ggcaggtgta cagcttgctc aactcgggct480cagagtacgt gccggccgga cctcagcgct ccgagagtag ctcccgggtg ctgctggccg540gcgcgcccca ggcccagcag cggcgcagcc acgggagccc ccggcgtcgg caggcgccgt600ccctgcccct gccggggcgc gtgggctcgg acaccgtgcg cggccaggcg cggcacccat660tcggctttgg ccaggtgccc gacaactggc gcgaggtggc cgtcggggac agcacgggca720tggccctggc ccgcacctcc gtctcccagc aacggcacgg gggctccgcc tcctcggtct780cggcttcggc cttcgccagc acctaccgcc agcagccctc ctacccgcag cagttcccct840acccgcaggc gcccttcgtc agccagtacg agaactacga ccccgcgtcg cggacctacg900accagggttt cgtgtactac cggcccgcgg gcggcggcgt gggcgcgggg gcggcggccg960tggcctcggc gggggtcatc tacccctacc agccccgggc gcgctacgag gagtacggcg 1020gcggcgaaga gctgcccgag tacccgcctc agggcttcta cccggccccc gagaggccct 1080acgtgccgcc gccgccgccg ccccccgacg gcctggaccg ccgctactcg cacagtctgt 1140acagcgaggg cacccccggc ttcgagcagg cctaccctga ccccggtccc gaggcggcgc 1200aggcccatgg cggagaccca cgcctgggct ggtacccgcc ctacgccaac ccgccgcccg 1260aggcgtacgg gccgccgcgc gcgctggagc cgccctacct gccggtgcgc agctccgaca 1320cgcccccgcc gggtggggag cggaacggcg cgcagcaggg ccgcctcagc gtaggcagcg 1380tgtaccggcc caaccagaac ggccgcggtc tccctgactt ggtcccagac cccaactatg 1440tgcaagcatc cacttatgtg cagagagccc acctgtactc cctgcgctgt gctgcggagg 1500agaagtgtct ggccagcaca gcctatgccc ctgaggccac cgactacgat gtgcgggtgc 1560tactgcgctt cccccagcgc gtgaagaacc agggcacagc agacttcctc cccaaccggc 1620
cacggcacac ctgggagtgg cacagctgcc accagcatta ccacagcatg gacgagttca 1680gccactacga cctactggat gcagccacag gcaagaaggt ggccgagggc cacaaggcca 1740gtttctgcct ggaggacagc acctgtgact tcggcaacct caagcgctat gcatgcacct 1800ctcataccca gggcctgagc ccaggctgct atgacaccta caatgcggac atcgactgcc 1860agtggatcga cataaccgac gtgcagcctg ggaactacat cctcaaggtg cacgtgaacc 1920caaagtatat tgttttggag tctgacttca ccaacaacgt ggtgagatgc aacattcact 1980acacaggtcg ctacgtttct gcaacaaact gcaaaattgt ccaatcctga tctccgggag 2040ggacagatgg ccaatctctc cccttccaaa gcaggccctg ctccccgggc agcctcccgc 2100cgaggggccc agcccccaac ccacaggcag ggaggggcat ccctccctgc cggcctcagg 2160gagcgaacgt ggatgaaaac cacagggatt ccggatgcca gaccccattt tatacttcac 2220ttttctctac agtgttgttt tgttgttgtt ggtttttatt ttttatactt tggccatacc 2280acagagctag attgcccagg tctgggctga ataaaacaag gtttttct2328<210>87<211>544<212>DNA<213>人<400>87aggcttttag aaaatttatt atgaattccg agaagtctgc tcatcatata cctcccccag 60ccccaaataa aacaaacaac atgtttgtac ataaagcctg gatttacttg gtacaaaatt120tgagtctttg aaaaaaatag ttaatggaaa atctcaataa aaattcattt tgaaagtaac180cagtactgtt cagaaataag gaagtcatgt tacttgagaa gtcacacagt tttattacag240aactatgtgt atatattttg ggtttaaaac ttgccaatag ctgtttgaaa ggatagctca300taatttattc aaatagatat tttattaatc aaatgttttt ggtttatcaa cataaccaaa360tgtataaaaa atgtttttaa atacaagaca taactataaa gtcatgaggc tgattgacct420tttaaactaa cataataaaa tctatatggt caaaatgagt ggtgatgctt taaggtaatg480attatgcgtc ccatctaagg atgctgcaat ggcctagggc agttttgaaa tgtctctttg540caac 544<210>88<211>5189<212>DNA<213>人
<400>88cttgcgaggt gagcatttcc aaggctgtgt gctcgtgggg tggggggaca cacgatgacc 60ttctcctcct caggaagacc taagagggaa gagcaaaccc cagcgagatc ccccctgtgc120tgatgatttt cagggacttg ttggcaactc agcgagggtt gccatagctt ttttatgtag180ggtgaccaga accggctgaa actggtttga ggcagatcag ctcctgaaca caatgcagtc240actgagctac tacagtagga tagcagcttc ctcccttcat ggcagccaaa agcagaggag300cttgcaggaa ggtaccatcc ctacacagta tgtgaatgca cacttagaca ccacacagca360ctggtacgtg actaatggag ccctaaaaga ttctgggtag agaagatgga aaaaaaggtg420caggtttgca gggtctgaga ttacttgggc ttttcctgcc tttttctttt gcttaaggga480tggacaagga gctgagattt atgaccctta ttagagaaaa aaatgtgcct tgctagggtg540gggacacttg gttgatgcag tctctctctc tctttctcgg tgtttataac aaaacaaaac600caaaatgaac tgaggggttt gtaatggtag tttgtttgtt gctggagaat gctactttgc660atgctttttt tctcttgcag ggtatgttct gtcttgtgct ttttctttta gaagctacta720aagggtgttg gggatgcttc tgactattat gaaggccaaa aggcctgttg actggggctg780cttttaaccc tttcctattt gctgagaatg cagccgtgtg acagtaactg aacattggtc840taaagtcttt ccaaaaggtc aaggttcaca agaacatctg ctcaaattaa tgaccatggg900ggatatgaag accccagact ttgatgacct cctggcagca tttgacatcc cagatatggt960cgatcctaaa gcagctattg agtctggaca cgatgaccat gaaagccaca tgaagcagaa 1020tgctcacgga gaggatgact cccacgcacc atcatcttct gatgtgggtg tcagcgttat 1080cgtcaagaat gttcggaaca ttgactcttc cgagggcggg gagaaagacg gccacaaccc 1140cactggcaat ggcttacata atgggtttct cacagcatcc tcccttgaca gttacagtaa 1200agatggagca aagtccttga aaggagatgt gcctgcctct gaggtgacac tgaaagactc 1260gacattcagc cagtttagcc cgatctccag tgctgaagag tttgatgacg acgagaagat 1320tgaggtggat gacccccctg acaaggagga catgcgatca agcttcaggt cgaatgtgtt 1380gacggggtcg gctccccagc aggactacga taagctgaag gcactcggag gggaaaactc 1440cagcaaaact ggactctcta cgtcaggcaa tgtggagaaa aacaaagctg ttaagagaga 1500aacagaagcc agttctataa acctgagtgt ttatgaacct tttaaagtca gaaaagcaga 1560ggataaattg aaggaaagct ctgacaaggt gctggaaaac agagtcctag atgggaagct 1620gagctccgag aagaatgaca ccagcctccc cagcgttgcg ccatcaaaga caaagtcgtc 1680
ctccaagctc tcgtcctgca tcgctgccat cgcggctctc agcgctaaaa aggcggcttc 1740agactcctgc aaagaaccag tggccaattc gagggaatcc tccccgttac caaaagaagt 1800aaatgacagt ccgagagccg ctgacaagtc tcctgaatcc cagaatctca tcgacgggac 1860caaaaaacca tccctgaagc aaccggatag tcccagaagc atctcaagtg agaacagcag 1920caaaggatcc ccgtcctctc ccgcagggtc cacaccagca atccccaaag tccgcataaa 1980aaccattaag acatcttctg gggaaatcaa gagaacagtg accagggtat tgccagaagt 2040ggatcttgac tctggaaaga aaccttccga gcagacagcg tccgtgatgg cctctgtgac 2100atcccttctg tcgtctccag catcagccgc cgtcctttcc tctcccccca gggcgcctct 2160ccagtctgcg gtcgtgacca atgcagtttc ccctgcagag ctcaccccca aacaggtcac 2220aatcaagcct gtggctactg ctttcctccc agtgtctgct gtgaagacgg caggatccca 2280agtcattaat ttgaagctcg ctaacaacac cacggtgaaa gccacggtca tatctgctgc 2340ctctgtccag agtgccagca gcgccatcat taaagctgcc aacgccatcc agcagcaaac 2400tgtcgtggtg ccggcatcca gcctggccaa tgccaaactc gtgccaaaga ctgtgcacct 2460tgccaacctt aaccttttgc ctcagggtgc ccaggccacc tctgaactcc gccaagtgct 2520aaccaaacct cagcaacaaa taaagcaggc aataatcaat gcagcagcct cgcaaccccc 2580caaaaaggtg tctcgagtcc aggtggtgtc gtccttgcag agttctgtgg tggaagcttt 2640caacaaggtg ctgagcagtg tcaatccagt ccctgtttac atcccaaacc tcagtcctcc 2700cgccaatgca gggatcacgt taccgacgcg tgggtacaag tgcttggagt gtggggactc 2760ctttgcactt gaaaagagtc tgacccagca ctacgacaga cggagcgtgc gcatcgaagt 2820aacgtgcaac cattgtacaa agaacctcgt tttttacaac aaatgcagcc tcctttccca 2880tgcccgtggg cataaggaga aaggggtggt aatgcaatgc tcccacttaa ttttaaagcc 2940agtcccagca gatcaaatga tagtttctcc gtcaagcaat acttccactt caacttccac 3000tcttcagagc cctgtgggag ctggcacaca cactgtcaca aaaattcagt ctggcataac 3060tgggacagtc atatcggctc cttcaagcac tcccatcacc ccagccatgc ccctagatga 3120agacccctcc aaactgtgta gacatagtct aaaatgtttg gagtgtaatg aagtcttcca 3180ggacgagaca tcactggcta cacatttcca gcaggctgca gatacgagtg gacaaaagac 3240ttgcactatc tgccagatgc tgcttcctaa ccagtgcagt tatgcatcac accagagaat 3300ccatcagcac aaatctccct acacctgccc tgagtgtggg gccatctgca ggtcggtgca 3360
cttccagacc cacgtcacca agaactgtct gcactacacg aggagagttg gttttcgatg 3420tgtgcattgc aatgttgtgt actctgatgt ggctgctctg aagtctcaca ttcaaggttc 3480tcactgtgaa gtcttctaca agtgtcctat ttgtccaatg gcgtttaagt ctgccccaag 3540cacacattcc cacgcctaca cacagcatcc tggcatcaag ataggagaac caaaaataat 3600atataagtgt tccatgtgcg acactgtgtt caccctgcaa accttgctgt atcgccactt 3660tgaccaacac attgaaaacc agaaggtgtc tgttttcaag tgtccagact gttctctttt 3720atatgcacag aagcaactta tgatggacca tatcaagtct atgcatggaa cattgaaaag 3780tattgaaggg cctccaaact tgggtataaa cttgcctttg agcattaagc ctgcaactca 3840aaattcagca aatcagaaca aagaggacac caaatccatg aatgggaaag agaaattgga 3900aaagaaatct ccatctcctg tgaaaaaatc aatggaaacc aagaaagtgg ccagtcctgg 3960gtggacgtgt tgggagtgtg actgcctgtt catgcagaga gatgtgtaca tatcccacgt 4020gaggaaggag cacgggaagc aaatgaagaa acacccctgc cgccagtgtg acaagtcttt 4080cagctcgtcc cacagcctgt gccggcacaa ccggatcaag cacaaaggca tcaggaaagt 4140gtacgcctgc tcgcactgcc cagactccag acgtaccttt accaaacgtt tgatgctgga 4200gaagcacgtc cagctgatgc atggcatcaa ggaccctgac ctgaaagaaa tgacagatgc 4260caccaatgag gaggaaacag aaataaaaga agacactaag gtccccagtc ccaagcggaa 4320gttggaagaa ccagttctgg agttcaggcc tccccgagga gcaatcactc aaccactgaa 4380aaagctgaaa atcaatgttt ttaaggttca caagtgtgcc gtgtgtggct tcaccaccga 4440aaacctgctg caattccacg aacacatccc tcagcacaaa tcggatggtt cttcctacca 4500gtgccgggag tgtggcctct gctacacgtc tcacgtctct ctgtccaggc acctcttcat 4560cgtacacaag ttaaaggaac ctcagccagt gtccaagcaa aatggggctg gggaagataa 4620ccaacaggag aacaaaccca gccacgagga tgaatcccct gatggcgccg tgtcagacag 4680aaagtgcaaa gtgtgcgcaa aaacttttga aactgaagct gccttaaata ctcacatgcg 4740gacacacggc atggccttca tcaaatccaa aaggatgagc tcagccgaga aatagccaca 4800gatgctccat gaggaaaatc cctgtccaca ttggaataaa aaagacattt ttgttacaaa 4860gtttgcagta taatagagtt aacagtactg tctaggctgt tgcaatatat tctctttcaa 4920tgtaccttcc ttcacctcgt cgtatatatc ctcgataagt attaaaacag tatttgagtt 4980taaaagagtt tgtatatatt taaatgaata actttttata ctctttgtta catgtttgta 5040tcagtattta gtggaaaacc atttgagttg ttttgggtta gaatttttct ttttgtactg 5100
tttctttaaa acagagttct tagtaacagg ggcagttcct gaattcaaat aaaccatttt 5160gtatgtttgg aaaaaaaaaa aaaaaaaaa 5189<210>89<211>1061<212>DNA<213>人<400>89ctctgttttc tcaaagctga agtcggctag gtttgcaaag ctgtgggctg agcactcagg 60caatcacact ctcagaaact gcggcggctc tggactgcag cctcccaagg ctccatgcca120gacaaagcat gcgtgtcaca cttgctacaa tagcctggat ggtttctttt gtctccaatt180attcacacac agcaaatatt ttgccagata tcgaaaatga agatttcatc aaagactgcg240ttcgaatcca taacaagttc cgatcagagg tgaaaccaac agccagtgat atgctataca300tgacttggga cccagcacta gcccaaattg caaaagcatg ggccagcaat tgccagtttt360cacataatac acggctgaag ccaccccaca agctgcaccc aaacttcact tcactgggag420agaacatctg gactgggtct gtgcccattt tttctgtgtc ttccgccatc acaaactggt480atgacgaaat ccaggactat gacttcaaga ctcggatatg caaaaaagtc tgtggccact540acactcaggt tgtttgggca gatagttaca aagttggctg cgcagttcaa ttttgcccta600aagtttctgg ctttgacgct ctttccaatg gagcacattt tatatgcaac tacggaccag660gagggaatta cccaacttgg ccatataaga gaggagccac ctgcagtgcc tgccccaata720atgacaagtg tttggacaat ctctgtgtta accgacagcg agaccaagtg aaacgttact780actctgttgt atatccaggc tggcccatat atccacgtaa cagatacact tctctctttc840tcattgttaa ttcagtaatt ctaatactgt ctgttataat taccattttg gtacagctca900agtaccctaa tttagttctt ttggactaat acaattcagg aaagaaaaaa cccaaaaacc960aacctcattc acatatggct tttttttaac caataacaat taggtgtact tctattttaa 1020aacatttcag aaaaaaatat atgttatagc aatactctta c 1061<210>90<211>1453<212>DNA<213>人<400>90agcgcgagtg ccagagccca gccggcgcgg agcgggagcg gtgcaggctg aggtctccga 60
gcggctcgcc atggctggcc cgcagcagca gcccccttac ctgcacctgg ccgagctgac120ggcgtcccag ttcctggaaa tatggaagca ctttgacgca gacggaaatg ggtatattga180aggtaaagag ctagaaaact ttttccaaga gctggagaag gcaaggaaag gctctggcat240gatgtcaaag agtgacaact ttggagaaaa gatgaaggag ttcatgcaga agtatgataa300aaactcagat gggaaaatcg agatggcaga gctggcgcag atcctgccaa ccgaagagaa360cttccttctg tgcttcaggc agcacgtggg ctccagcgcc gagtttatgg aggcttggcg420gaagtacgac acagacagga gtggctacat cgaagccaat gagctcaagg gattcctgtc480agacctgctg aagaaggcga accggccgta cgatgagccc aagctccagg aatacaccca540aaccatacta cggatgtttg acttgaacgg ggatggcaaa ttgggcctct cagagatgtc600ccgactcctg cctgtccagg aaaacttcct gcttaaattt cagggcatga agctgacctc660agaggagttt aacgcgatct tcacatttta cgacaaggat agaagcggct acattgacga720gcatgagctg gatgcccttt tgaaggatct gtacgagaaa aacaaaaagg aaatcaatat780tcaacagctc accaactaca gaaagagcgt catgtccttg gcagaggcag ggaagctcta840ccgcaaggac ctggagattg tgctctgcag cgagcccccc atgtaaagtg gggacggggg900ctgcttctcc acctccccca aaccctgctt ctgctgccct gatgcgtcta cccagactca960gagaccgtga gcgccccgcc cccaccccta cagcctgcac acacctgcct gcagagcagg 1020aaacgagaga tagaggatgg gcagctgggg ggctgtcctg agccccctgc acccacccct 1080gcccaggcag tctttgctca gtggatcaca cacatggaag gtgatggggg catgggtgga 1140gggtccctaa ttctcttcgc tgtgatgcat gagctccctc gctgtatgat ttaggcttct 1200atgtccaaca gagtggactc ttccctctcg ctcccctctg ccggtccccc atgccaccac 1260ccaccccaaa cttccaggtt ccatccacca ccttgccaat ggtgtagctg tcctctcaga 1320actcctgtgt gtggaaggca cccgcccttt ccttgccttc tttactcggc gtgctccttt 1380tctctttggg tttcttgttt accaaagaag agtttacaga caataaaatg gaaaggtcct 1440gctgtggaaa ctt 1453<210>91<211>2223<212>DNA<213>人<400>91tcagtgtgtg cggaacgcaa gcagccgaga gcggagaggc gccgctgtag ttaactcctc 60
cctgcccgcc gcgccgaccc tccccaggaa cccccaggga gccagcatga agcgagctca120ccccgagtac agctcctcgg acagcgagct ggacgagacc atcgaggtgg agaaggagag180tgcggacgag aatggaaact tgagttcggc tctaggttcc atgtccccaa ctacatcttc240ccagattttg gccagaaaaa gacggagagg aataattgag aagcgccgac gagaccggat300caataacagt ttgtctgagc tgagaaggct ggtacccagt gcttttgaga agcagggatc360tgctaagcta gaaaaagccg agatcctgca gatgaccgtg gatcacctga aaatgctgca420tacggcagga gggaaaggtt actttgacgc gcacgccctt gctatggact atcggagttt480gggatttcgg gaatgcctgg cagaagttgc gcgttatctg agcatcattg aaggactaga540tgcctctgac ccgcttcgag ttcgactggt ttcgcatctc aacaactacg cttcccagcg600ggaagccgcg agcggcgccc acgcgggcct cggacacatt ccctggggga ccgtcttcgg660acatcacccg cacatcgcgc acccgctgtt gctgccccag aacggccacg ggaacgcggg720caccacggcc tcacccacgg aaccgcacca ccagggcagg ctgggctcgg cacatccgga780ggcgcctgct ttgcgagcgc cccctagcgg cagcttcgga ccggtgctcc ctgtggtcac840ctccgcctcc aaactgtcgc tgcctctgct ctcctcagtg gcctccctgt cggccttccc900cttctctttc ggctccttcc acttactgtc tcccaatgca ctgagccctt cagcacccac960gcaggctgca aaccttggca agccctatag accttggggg acggagatcg gagcttttta 1020aagaactgat gtagaatga8 ggaggggaaa gtttaaaatc ccagctgggc tggactgttg 1080ccaacatcac cttaaagtcg tcagtaaaag taaaaaggaa aaaggtacac tttcagataa 1140tttttttttt aaagactaaa ggtttgttgg tttactttta tcttttttaa tgtttttttc 1200atcatgtcat gtattagcag tttttaaaaa ctagttgtta aattttgttc aagacattaa 1260attgaaatag tgagtataag ccaacacttt gtgataggtt tgtactgtgc ctaatttact 1320ttgtaaacca gaatgattcc gtttttgcct caaaatttgg ggaatcttaa catttaggta 1380tttttggtct gtttttctcc ttgtatagtt atggtctgtt tttagaatta attttccaaa 1440ccactatgct taatgttaac atgattctgt ttgttaatat tttgacagat taaggtgttg 1500tataaataat attcttttgg ggggagggga actatattga attttatatt tctgagcaaa 1560gcgttgacaa atcagatgat cagctttatc caagaaagaa gactagtaaa ttgtctgcct 1620cctatagcag aaaggtgaat gtacaaactg ttggtggcct gaatccatct gaccagctgc 1680tggtatctgc caggactggc agttctgatt tagttaggag gaccgctgat aggttaggtc 1740tcatttggag tgttggtgga aaggaaactg aaggtaattg aatagaatac gcctgcattt 1800
accagcccca gcaacacaaa gaatttttaa tcacacggat ctcaaattca caaatgttaa1860catggataag tgatcatggt gtgcgagtgg tcaattgagt agtacagtgg aaactgttaa1920atgcataacc taattttcct gggactgcca tattttcttt taactggaaa tttttatgtg1980agttttcctt ttggtgcatg gaactgtggt tgccaaggta tttaaaaggg ctttcctgcc2040tccttctctt tgatttattt aatttgattt gggctataaa atatcatttt tcaggtttat2100tcttttagca ggtgtagtta aacgacctcc actgaactgg gtttgacctc tgttgtactg2160atgtgttgtg actaaataaa aaagaaagaa caaagtaaaa aaaaaaaaaa aaaaaaaaaa2220aaa 2223<210>92<211>4712<212>DNA<213>人<400>92cccggcggtg gcggcgtctc tggccggcct tggtgcggcg agccgagcga ggcagctctg 60agccgcgcgg aaatctggca ttttttaaag tttgcgcccc acaaagagga aatattccaa120aggtactcag gatgtaaaag gggagatctt cacagatgcc tccgtggatg gcatggcaat180ccatccatca atgagaagac catgatttct tttaattttc tgtgtgtttc cacattcccc240agtgagaatt cttccacctt tttttgtgcc atgggaaaaa cctgaagggc aggcagagct300gctcccgaac ttgtgacctt ctctgaggtt gcagcggctc ttgtagaaca tgactctggg360acatcacttc cttttgtttt ctttcggagc tgaaccaaag aatgtgcacc ctctttctct420agtgctgtgg tgtctgctta tttttgtatt tgtgctttcc atccatcttc tgtgatcaca480aggcattctt aaggttttct agcacgactt gcggacatcc agactcgtgg ggggcccacc540catggctcgg taagccagca gcccagggca ctggcactac catgaggcac tgcattaatt600gctgcataca gctgttaccc gacggcgcac acaagcagca ggtcaactgc caagggggcc660cccatcacgg tcaccaggcg tgccccacgt gcaaaggaga aaacaaaatt ctgtttcgtg720tggacagtaa gcagatgaac ttgcttgctg ttctcgaagt gaggactgaa gggaacgaaa780actggggtgg gtttttgcgc ttcaaaaagg ggaagcgatg tagcctcgtt tttggactga840taataatgac cttggtaatg gcttcttaca tcctttctgg ggcccaccaa gagcttctga900tctcatcacc tttccattac ggaggcttcc ccagcaaccc cagcttgatg gacagcgaaa960acccaagtga cacaaaggag catcaccacc aatcctctgt aaataatatt tcatacatga 1020
aggactatcc aagcattaaa ttaattatca acagcatcac aactaggatt gagttcacga 1080ccagacagct cccagactta gaagacctta agaagcagga gttgcatatg ttttcagtca 1140tccccaacaa attccttcca aacagtaaga gcccctgttg gtacgaggag ttctcggggc 1200agaacaccac cgacccctac ctcaccaact cctacgtgct ctactccaag cgcttccgct 1260ccaccttcga cgccctgcgc aaggccttct ggggccacct ggcgcacgcg cacgggaagc 1320acttccgcct gcgctgcctg ccgcacttct acatcatagg gcagcccaag tgcgggacca 1380cagacctcta tgaccgcctg cggctgcacc ctgaggtcaa gttctccgcc atcaaggagc 1440cacactggtg gacccggaag cgctttggaa tcgtccgcct aagagatggg ctgcgagacc 1500gctatcccgt ggaagattat ctggacctct ttgacctggc cgcacaccag atccatcaag 1560gactgcaggc cagctctgca aaggagcaga gcaagatgaa tacaatcatt atcggggagg 1620ccagtgcctc cacgatgtgg gataataatg cctggacgtt cttctacgac aacagcacgg 1680atggcgagcc accgtttctg acgcaggact tcatccacgc ctttcagcca aatgccagac 1740tgattgtcat gctcagggac cctgtggaga ggttgtactc agactatctc tactttgcaa 1800gttcgaataa atccgcggac gacttccatg agaaagtgac agaagcactg cagctgtttg 1860aaaattgcat gcttgattat tcactgcgcg cctgcgtcta caacaacacc ctcaacaacg 1920ccatgcctgt gaggctccag gttgggctct atgctgtgta ccttctggac tggctcagcg 1980tttttgacaa gcaacagttt ctcattcttc gcctggaaga tcatgcatcc aacgtcaagt 2040acaccatgca caaggtcttc cagtttctga acctagggcc cttaagtgag aagcaggagg 2100ctttgatgac caagagcccc gcatccaatg cacggcgtcc cgaggaccgg aacctggggc 2160ccatgtggcc catcacacag aagattctgc gggatttcta caggcccttc aacgctaggc 2220tggcgcaggt cctcgcggat gaggcgtttg cgtggaagac gacgtgagag ctgaattgtt 2280gctgcacgtg ctgggcccgc caatgccgtc atcatcagga ttttacaaat ctctttgcgg 2340ggaactgttt cactcatggt atggaaaacc ccaggactct gccactctag gcacacatga 2400attataacca ttttggaatt tccttcgtga tgttcgagag ctcagcaatg gacccctcac 2460agagctcctc tatccgaggc cattggagac cccagtttct caagaattca gctctgctct 2520gagcgtcctg gagcttgggg atgcagccag ctggcctgca ctgggtgtgg agagaacacc 2580tagggaaggc agcctggccc tgcccgcctc cgccttctgg agagcctctg ggttctgagt 2640cagcaagcca gaggtcatgc cacaggcctg gctggaactt acacttcacg ttcccttttt 2700
ttccccctag agatggggtc tcgccgtgtt gcacagactg tctgtattca atggctatct 2760tcacaggtgt gatcatacca cattcacttc tgaaacactc ttgttgcgat cgctaacctc 2820actgggacag agaaccgcag tctttcgaga atggaggctc ttcatttttt ttttctcctt 2880tactccaaac tcagccctcc agtttcttca gatgtaaacc ctgttaacgt cactgtttcc 2940aaaaggaaaa aaataagtca gtttttggca gcaccttcat ctttctgacc tcctcctatt 3000ctgtccttgt ggacttatgt ttaacataga aaatgaatgc gtttaaaaca aaaccacttt 3060ctgcatttaa ccagtcctgg ctctctctct gctgcctctt catacgtttt ctcaagaact 3120tcagtttata attggaagag aaatttttgc tgttaatgcc agaatgagca acctcaagga 3180attgaacact tcttggaaaa tctaggtaat tcaagccctc atcaggttta caagatcatc 3240agagaaacag aggattttaa tttttagttc tggccggcta caggctccat ttctctgcct 3300tcccattgga aatagtttat ttccacattc tccactgcgt gtggtcaaag ttcctcaccc 3360agcaagggac tatagatact cgtgtcccaa ttccaaaaca caatgcacaa gctgaacttg 3420ggctgaacgt ggcgtgttga gatttggaat gaggtttcta agagccgtgt tcttcatgga 3480attttccagg ccacttggca gcttggttta ccgatggatg ggctagagat cttgtcgttt 3540cttggaagtc acagggaaga ttgaagagaa cgcttgagca tccttggcaa cagcccaggt 3600gggacctgga tgaagctttg cactcaagta ttgtcaaggg aagcttcctg tgaaccaaag 3660ttctcaggcc aaggtctcgc ccaccaaagc cagaaagtgc aagcacccgt ctacccagct 3720ctaacttgta tgtgtgagac agaccaggct tcgggggtag gaggatctgc agttgttcag 3780ccgtctttct gctggtgttg tctttctgcc atcagagaag ggacacacag cccgttcgaa 3840ggtgtgcaga gggctctgag cgccaggatg gccagggctg tttttgctac tgaaggagcg 3900tgtgtcctga actcccactt gcagggacag tccccacctt ctctatagcc ggcactggga 3960gcagccgcca gcagggaaat ctggcctgag cacaaggatg ctttagggag agatcacttc 4020agtgtgtgtg tatatttatt tgcagtacag tgcgcgcgtg tgtgtgtgtg tacgcgcacg 4080tgtgggtgag tgcgtcttct gagtgggttc tgttcagttg ctaatgaggc tcctccgctc 4140tggacacaac ccttttatag attaatttct ctgccaatta acttgtcatt ttcagtacat 4200attttactat tccacaccaa ccataattac aacaagggat ttttcttatg cactcctatg 4260catgtgaata acatgtggtg taattctgct tcttacagaa gtattactga aggtattatt 4320tccaatatta tttggtttat tatgcggatc ttttttatat atgcagtccc atcccttctg 4380tgccactcaa tgccatccag acatggtttt tccctccagg ggcctttctc tccagagggc 4440
acttcggctg cctctgcttc ctctcattcg aggcccggct cttgctgaca gaataggttc 4500cgttctgggc ggtggttctc gagcctgcca ttcaaaacca aagcaaattg gagcatttct 4560cacaacatgg tattgaagtt cctttttgtt ctcaaaagtt gtgaccgtgt taaattgtac 4620tcccttagtc ctgtaaggta tgttaagtga atcgcagtta cgctgtactt ttattaatat 4680ttaacataat taaagatgga cccataagag tg 4712<210>93<211>1398<212>DNA<213>人<400>93gtgtgaaatc ttcagagaag aatttctctt tagttctttg caagaaggta gagataaaga 60cactttttca aaaatggcaa tggtatcaga attcctcaag caggcctggt ttattgaaaa120tgaagagcag gaatatgttc aaactgtgaa gtcatccaaa ggtggtcccg gatcagcggt180gagcccctat cctaccttca atccatcctc ggatgtcgct gccttgcata aggccataat240ggttaaaggt gtggatgaag caaccatcat tgacattcta actaagcgaa acaatgcaca300gcgtcaacag atcaaagcag catatctcca ggaaacagga aagcccctgg atgaaacact360taagaaagcc cttacaggtc accttgagga ggttgtttta gctctgctaa aaactccagc420gcaatttgat gctgatgaac ttcgtgctgc catgaagggc cttggaactg atgaagatac480tctaattgag attttggcat caagaactaa caaagaaatc agagacatta acagggtcta540cagagaggaa ctgaagagag atctggccaa agacataacc tcagacacat ctggagattt600tcggaacgct ttgctttctc ttgctaaggg tgaccgatct gaggactttg gtgtgaatga660agacttggct gattcagatg ccagggcctt gtatgaagca ggagaaagga gaaaggggac720agacgtaaac gtgttcaata ccatccttac caccagaagc tatccacaac ttcgcagagt780gtttcagaaa tacaccaagt acagtaagca tgacatgaac aaagttctgg acctggagtt840gaaaggtgac attgagaaat gcctcacagc tatcgtgaag tgcgccacaa gcaaaccagc900tttctttgca gagaagcttc atcaagccat gaaaggtgtt ggaactcgcc ataaggcatt960gatcaggatt atggtttccc gttctgaaat tgacatgaat gatatcaaag cattctatca 1020gaagatgtat ggtatctccc tttgccaagc catcctggat gaaaccaaag gagattatga 1080gaaaatcctg gtggctcttt gtggaggaaa ctaaacattc ccttgatggt ctcaagctat 1140gatcagaaga ctttaattat atattttcat cctataagct taaataggaa agtttcttca 1200
acaggattac agtgtagcta cctacatgct gaaaaatata gcctttaaat catttttata1260ttataactct gtataataga gataagtcca ttttttaaaa atgttttccc caaaccataa1320aaccctatac aagttgttct agtaacaata catgagaaag atgtctatgt agctgaaaat1380aaaatgacgt cacaagac 1398<210>94<211>2972<212>DNA<213>人<400>94gcgcgcggct ccgatgggaa gcatgacccg ggtggcggga caagacttgc ttcccggcca 60cgcgcgctcg gccggccgtg gggcggggca taggcgtgac gtggtgtcgc gtatcgagtc120tccgccccct tcccgcctcc ccgtatataa gacttcgccg agcactctca ctcgcacaag180tggaccgggg tgttgggtgc tagtcggcac cagaggcaag ggtgcgagga ccacggccgg240ctcggacgtg tgaccgcgcc tagggggtgg cagcgggcag tgcggggcgg caaggcgacc300atggarcttt tgcggactat cacctaccag ccagccgcca gcaccaaaat gtgcgagcag360gcgctgggca agggttgcgg aggggactcg aagaagaagc ggccgccgca gccccccgag420gaatcgcagc cacctcagtc ccaggcgcaa gtgcccccgg cggcccctca ccaccatcac480caccattcgc actcggggcc ggagatctcg cggattatcg tcgaccccac gactgggaag540cgctactgcc ggggcaaagt gctgggaaag ggtggctttg caaaatgtta cgagatgaca600gatttgacaa ataacaaagt ctacgccgca aaaattattc ctcacagcag agtagctaaa660cctcatcaaa gggaaaagat tgacaaagaa atagagcttc acagaattct tcatcataag720catgtagtgc agttttacca ctacttcgag gacaaagaaa acatttacat tctcttggaa780tactgcagta gaaggtcaat ggctcatatt ttgaaagcaa gaaaggtgtt gacagagcca840gaagttcgat actacctcag gcagattgtg tctggactga aataccttca tgaacaagaa900atcttgcaca gagatctcaa actagggaac ttttttatta atgaagccat ggaactaaaa960gttggggact tcggtctggc agccaggcta gaacccytgg aacacagaag gagaacgata 1020tgtggtaccc caaattatct ctctcctgaa gtcctcaaca aacaaggaca tggctgtgaa 1080tcagacattt gggccctggg ctgtgtaatg tatacaatgt tactagggag gcccccattt 1140gaaactacaa atctcaaaga aacttatagg tgcataaggg aagcaaggta tacaatgccg 1200tcctcattgc tggctcctgc caagcactta attgctagta tgttgtccaa aaacccagag 1260
gatcgtccca gtttggatga catcattcga catgactttt ttttgcaggg cttcactccg 1320gacagactgt cttctagctg ttgtcataca gttccagatt tccacttatc aagcccagct 1380aagaatttct ttaagaaagc agctgctgct ctttttggtg gcaaaaaaga caaagcaaga 1440tatattgaca cacataatag agtgtctaaa gaagatgaag acatctacaa gcttaggcat 1500gatttgaaaa agacttcaat aactcagcaa cccagcaaac acaggacaga tgaggagctc 1560cagccaccta ccaccacagt tgccaggtct ggaacacccg cagtagaaaa caagcagcag 1620attggggatg ctattcggat gatagtcaga gggactcttg gcagctgtag cagcagcagt 1680gaatgccttg aagacagtac catgggaagt gttgcagaca cagtggcaag ggttcttcgg 1740ggatgtctgg aaaacatgcc ggaagctgat tgcattccca aagagcagct gagcacatca 1800tttcagtggg tcaccaaatg ggttgattac tctaacaaat atggctttgg gtaccagctc 1860tcagaccaca ccgtcggtgt ccttttcaac aatggtgctc acatgagcct ccttccagac 1920aaaaaaacag ttcactatta cgcagagctt ggccaatgct cagttttccc agcaacagat 1980gctcctgagc aatttattag tcaagtgacg gtgctgaaat acttttctca ttacatggag 2040gagaacctca tggatggtgg agatctgcct agtgttactg atattcgaag acctcggctc 2100tacctccttc agtggctaaa atctgataag gccctaatga tgctctttaa tgatggcacc 2160tttcaggtga atttctacca tgatcataca aaaatcatca tctgtagcca aaatgaagaa 2220taccttctca cctacatcaa tgaggatagg atatctacaa ctttcaggct gacaactctg 2280ctgatgtctg gctgttcatc agaattaaaa aatcgaatgg aatatgccct gaacatgctc 2340ttacaaagat gtaactgaaa gacttttcga atggacccta tgggactcct cttttccact 2400gtgagatcta cagggaagcc aaaagaatga tctagagtat gttgaagaag atggacatgt 2460ggtggtacga aaacaattcc cctgtggcct gctggactgg gtggaaccca gaaccaggct 2520aaggcataca gttcttgact ttggacaatc ccaagagtga accagaatgc agttttcctt 2580gagatacctg ttttaaaagg tttttcagac aattttgcag aaaggtgcat tgattcttaa 2640attctctctg ttgagagcat ttcagccaga ggactttgga actgtgaata tacttcctga 2700aggggaggga gaagggagga agctcccatg ttgtttaaag gctgtaattg gagcagcttt 2760tggctgcgta actgtgaact atggccatat ataatttttt ttcattaatt tttgaagata 2820cttgtggctg gaaaagtgca ttccttgtta ataaactttt tatttattac agcccaaaga 2880gcagtattta ttatcaaaat gtcttttttt ttatgttgac cattttaaac cgttggcaat 2940
aaagagtatg aaaacgcaaa aaaaaaaaaa aa 297权利要求
1.评估结肠直肠癌状态的方法，该方法包括对选自Seq.ID.No.7-13的基因组合进行差异调控鉴定。
2.权利要求1的方法，其中将所述基因的表达模式与指示复发患者的表达模式进行比较。
3.权利要求2的方法，其中所述表达模式的比较是通过模式识别方法进行的。
4.权利要求3的方法，其中所述模式识别方法包括使用Cox比例风险分析。
5.权利要求1的方法，其中所述方法是在原发肿瘤样本上进行的。
6.权利要求1的方法，其中所述组合包括相应于Seq.ID.No.7-13的所有基因。
7.权利要求1的方法，其进一步包括选自Seq.ID.No.14-28的基因。
8.权利要求7的方法，其中所述组合包括相应于Seq.ID.No.14-28的所有基因。
9.权利要求6的方法，其进一步包括包含Seq.ID.No.14-28的基因组合。
10.权利要求1的方法，其中被调控基因的表达至少有2倍的差异。
11.权利要求1的方法，其中指示差异调控的p值小于.05。
12.权利要求1的方法，其进一步包括非基于遗传学的结肠直肠诊断。
13.预后组合，其包含一种基因组合的分离的核酸序列、其互补序列、或其部分，其中所述基因组合包括Seq.ID.No.6和选自Seq.ID.No.7-13的基因。
14.权利要求13的方法，其中所述的组合包括相应于Seq.ID.No.14-28的所有基因。
15.权利要求13的方法，其进一步包括选自Seq.ID.No.14-28的基因。
16.权利要求15的方法，其中所述组合包括权利要求15的所有基因。
17.权利要求13的组合，其处于适于对其中所含基因进行差异表达鉴定的基质中。
18.权利要求17的组合，其中所述基质是微阵列。
19.权利要求18的组合，其中所述微阵列是cDNA微阵列。
20.权利要求18的组合，其中所述微阵列是寡核苷酸微阵列。
21.对结肠直肠癌患者的预后进行评价的试剂盒，其包括用于检测一种基因组合的分离的核酸序列、其互补序列、或其部分的材料，其中所述基因组合包含Seq.ID.No.6和选自Seq.ID.No.7-13的基因。
22.权利要求21的试剂盒，其中所述基因是相应于Seq.ID.No.7-13的所有基因。
23.权利要求21的试剂盒，其进一步包括选自Seq.ID.No.14-28的基因。
24.权利要求23的试剂盒，其中所述基因是相应于Seq.ID.No.14-28的所有基因。
25.权利要求23的试剂盒，其进一步包括进行微阵列分析的试剂。
26.权利要求23的试剂盒，其进一步包括用以检测所述核酸序列、其互补序列、或其部分的介质。
27.评估结肠直肠癌状态的制品，其包括用于鉴定一种基因组合的分离的核酸序列、其互补序列、或其部分的材料，其中所述基因组合包含Seq.ID.No.6和选自Seq.ID.No.7-13的基因。
28.权利要求27的制品，其中所述基因是相应于Seq.ID.No.7-13的所有基因。
29.权利要求28的制品，其进一步包括选自Seq.ID.No.14-28的基因。
30.权利要求29的制品，其中所述基因是相应于Seq.ID.No.14-28的所有基因。
31.评估结肠直肠癌的试剂盒，其包括检测Seq.ID.No.7-13表达的试剂。
32.权利要求31的试剂盒，其进一步包括检测Seq.ID.No.14-28表达的试剂。
33.治疗结肠直肠癌患者的方法，其包括基于Seq.ID.No.7-28的基因的表达来判断患者是否具有高复发风险，以及对于有高复发风险的患者进行辅助治疗。
全文摘要
本发明提供了一种通过分析一组基因的表达判断结肠直肠癌预后的方法。其中包括显示在微阵列等各种介质上的基因表达模式，以及含有基因表达模式的试剂盒。
文档编号C12Q1/68GK1637151SQ200410083279
公开日2005年7月13日 申请日期2004年8月27日 优先权日2003年8月28日
发明者Y·王 申请人:维里德克斯有限责任公司