1.一种生物标志物作为hbv相关肝癌检测、hbv相关肝癌预后或治疗靶点的用途，其特征在于，所述生物标志物选自anillin,actin binding protein(anln),cyclin b1(ccnb1),bub1 mitotic checkpoint serine/threonine kinase b(bub1b),epithelialcell transforming 2(ect2),rac gtpase activating protein 1(racgap1),estrogenreceptor 1(esr1),pdz binding kinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotide reductase regulatory subunit m2(rrm2),nima relatedkinase 2(nek2),protein regulator of cytokinesis 1(prc1),decorin(dcn),insulinlike growth factor 1(igf1),c-x-c motif chemokine ligand 12(cxcl12),hepatocytegrowth factor(hgf),secreted phosphoprotein 1(spp1),hyaluronan mediatedmotility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)中的一种或多种。
2.一种hbv相关肝癌检测试剂盒，其特征在于：所述试剂盒中含有能够定量检测anillin,actin binding protein(anln),cyclin b1(ccnb1),bub1mitotic checkpointserine/threonine kinase b(bub1b),epithelial cell transforming 2(ect2),racgtpase activating protein 1(racgap1),estrogen receptor 1(esr1),pdz bindingkinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotidereductase regulatory subunit m2(rrm2),nima related kinase 2(nek2),proteinregulator of cytokinesis 1(prc1),decorin(dcn),insulin like growth factor 1(igf1),c-x-c motif chemokine ligand 12(cxcl12),hepatocyte growth factor(hgf),secreted phosphoprotein 1(spp1),hyaluronan mediated motility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的试剂。
3.如权利要求2所述的试剂盒，其特征在于，所述试剂盒还联合检测其他肝癌标记物的表达，其中，所述的其他肝癌标记物包括：甲胎蛋白afp、甲胎蛋白异质体afp-l3、血清岩藻糖苷酶afu、硫酸肝素蛋白多糖3gpc3、异常凝血酶原dcp、谷氨酰胺转移酶酶ii或组合。
4.如权利要求2所述的试剂盒，其特征在于，所述试剂盒含有定量检测anillin,actinbinding protein(anln),cyclin b1(ccnb1),bub1 mitotic checkpoint serine/threonine kinase b(bub1b),epithelial cell transforming 2(ect2),rac gtpaseactivating protein 1(racgap1),estrogen receptor 1(esr1),pdz binding kinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotide reductaseregulatory subunit m2(rrm2),nima related kinase 2(nek2),protein regulator ofcytokinesis 1(prc1),decorin(dcn),insulin like growth factor 1(igf1),c-x-cmotif chemokine ligand 12(cxcl12),hepatocyte growth factor(hgf),secretedphosphoprotein 1(spp1),hyaluronan mediated motility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的特异性扩增基因引物、特异性识别基因的探针或特异性结合蛋白的抗体或配体。
5.特异性识别anillin,actin binding protein(anln),cyclin b1(ccnb1),bub1mitotic checkpoint serine/threonine kinase b(bub1b),epithelial celltransforming 2(ect2),rac gtpase activating protein 1(racgap1),estrogenreceptor 1(esr1),pdz binding kinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotide reductase regulatory subunit m2(rrm2),nima relatedkinase 2(nek2),protein regulator of cytokinesis 1(prc1),decorin(dcn),insulinlike growth factor 1(igf1),c-x-c motif chemokine ligand 12(cxcl12),hepatocytegrowth factor(hgf),secreted phosphoprotein 1(spp1),hyaluronan mediatedmotility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的基因或其编码蛋白的试剂的用途，用于制备检测hbv相关肝癌的试剂盒。
6.一种hbv相关肝癌预后试剂盒，其特征在于：所述试剂盒中含有能够定量检测anillin,actin binding protein(anln),cyclin b1(ccnb1),bub1 mitotic checkpointserine/threonine kinase b(bub1b),epithelial cell transforming 2(ect2),racgtpase activating protein 1(racgap1),estrogen receptor 1(esr1),pdz bindingkinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotidereductase regulatory subunit m2(rrm2),nima related kinase 2(nek2),proteinregulator of cytokinesis 1(prc1),decorin(dcn),insulin like growth factor 1(igf1),c-x-c motif chemokine ligand 12(cxcl12),hepatocyte growth factor(hgf),secreted phosphoprotein 1(spp1),hyaluronan mediated motility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的试剂。
7.如权利要求6所述的试剂盒，其特征在于，所述试剂盒还联合检测其他肝癌标记物的表达，其中，所述的其他肝癌标记物包括：甲胎蛋白afp、甲胎蛋白异质体afp-l3、血清岩藻糖苷酶afu、硫酸肝素蛋白多糖3gpc3、异常凝血酶原dcp、谷氨酰胺转移酶酶ii或组合。
8.如权利要求6所述的试剂盒，其特征在于，所述试剂盒含有定量检测anillin,actinbinding protein(anln),cyclin b1(ccnb1),bub1 mitotic checkpoint serine/threonine kinase b(bub1b),epithelial cell transforming 2(ect2),rac gtpaseactivating protein 1(racgap1),estrogen receptor 1(esr1),pdz binding kinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotide reductaseregulatory subunit m2(rrm2),nima related kinase 2(nek2),protein regulator ofcytokinesis 1(prc1),decorin(dcn),insulin like growth factor 1(igf1),c-x-cmotif chemokine ligand 12(cxcl12),hepatocyte growth factor(hgf),secretedphosphoprotein 1(spp1),hyaluronan mediated motility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的特异性扩增基因引物、特异性识别基因的探针或特异性结合蛋白的抗体或配体。
9.特异性识别anillin,actin binding protein(anln),cyclin b1(ccnb1),bub1mitotic checkpoint serine/threonine kinase b(bub1b),epithelial celltransforming 2(ect2),rac gtpase activating protein 1(racgap1),estrogenreceptor 1(esr1),pdz binding kinase(pbk),dna topoisomerase ii alpha(top2a),cyclin dependent kinase 1(cdk1),assembly factor for spindle microtubules(aspm),ribonucleotide reductase regulatory subunit m2(rrm2),nima relatedkinase 2(nek2),protein regulator of cytokinesis 1(prc1),decorin(dcn),insulinlike growth factor 1(igf1),c-x-c motif chemokine ligand 12(cxcl12),hepatocytegrowth factor(hgf),secreted phosphoprotein 1(spp1),hyaluronan mediatedmotility receptor(hmmr),或denticleless e3 ubiquitin protein ligase homolog(dtl)的基因或其编码蛋白的试剂的用途，用于制备hbv相关肝癌预后试剂盒。
10.如权利要求2或权利要求6所述试剂盒，其特征在于，所述hbv相关肝癌为hbv相关肝细胞癌。