专利名称：人gsk3的结晶方法及其新的晶体结构的制作方法
技术领域：
本发明关于人糖原合成酶激酶3(GSK3)的三维结构；关于由GSK3构建物、腺苷二磷酸和磷酸化肽组成的三元复合物的晶体结构；关于形成GSK3三元复合物晶体的方法；关于确定GSK3三元复合物晶体结构的方法；以及关于使用此GSK3三元复合物的三维结构来鉴定可能的治疗化合物，以治疗由GSK3活性所介导的各种疾病的方法。
背景技术：
糖原合成酶激酶3(GSK3)是一种丝氨酸/苏氨酸激酶，已鉴定到其α和β两种异构形式(Woodgett，Trends Biochen.Sci.，16177-81(1991))。GSK3的这两种异构形式在静止细胞中具有组成型活性。GSK3最初被鉴定为一种能通过直接磷酸化抑制糖原合成酶的激酶。胰岛素的活化可导致GSK3失去活性，从而引起该糖原合成酶活化以及其他可能的胰岛素依赖作用，比如葡萄糖转运。随后发现，其他类似于胰岛素的信号通过受体酪氨酸激酶(RTKs)传递的生长因子，也可灭活GSK3，这些信号传递分子的例子包括IGF-1和EGF(Saito等，Biochem.J.30327-31，1994；Welsh等，Biochem.J.294625-29和Cross等，Biochem.J.30321-26，1994)。
可采用能抑制GSK3活性的制剂来治疗GSK3活性所介导的疾病。并且，GSK3的抑制模拟了生长因子信号通路的活化，因此GSK3抑制剂可用于治疗因此通路活性不足所引起的疾病。可以用GSK3抑制剂治疗的疾病的例子包括糖尿病、阿尔茨海默氏病、中央神经系统疾病如躁郁症、以及免疫增强相关疾病。
由于GSK3抑制剂可用于治疗很多疾病，鉴定此新的GSK3抑制剂是很需要的。本发明提供了一种鉴定可能治疗由GSK3活性所介导的各种疾病的治疗化合物的方法。本发明的方法利用含有蛋白催化结构域的GSK3三元复合物的三维结构，来鉴定可能的治疗化合物以及优化先导治疗化合物的结构。
发明概述在本发明中，提供了人糖原合成酶激酶3(GSK3)构建物、腺苷二磷酸和磷酸化肽的三元复合物的三维结构。
在一个方面，本发明提供了包含人糖原合成酶激酶3-β(GSK3-β)构建物的三元GSK3复合物的晶体，其含有蛋白质的催化激酶结构域、腺苷二磷酸和磷酸化肽。在一实施方式中，该晶体包含GSK3构建物和磷酸化肽。所述GSK3构建物可以具有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型，所述磷酸化肽可以是二磷酸化多肽，所述的晶体可以具有表2所列的原子坐标。
在本发明的另一方面，提供了一种使GSK3三元复合物结晶的方法，以提供用于结构测定的足够的GSK3晶体。在一实施方式中，此方法包括使纯化的GSK3蛋白结晶以提供具有生物活性的晶体化GSK3蛋白，其中该晶体化GSK3蛋白质含有GSK3构建物和磷酸化多肽，并且该晶体化GSK3蛋白质可用x-射线晶体学分辨，以获得适用于确定晶体化GSK3蛋白三维结构的x-射线图。在一实施方式中，GSK3蛋白的结晶包括采用悬滴蒸汽扩散法结晶。所述GSK3构建物可以具有SEQ IDNO1所示的氨基酸序列或其活性突变体或变型，所述磷酸化肽可以是二磷酸化多肽，所述的晶体可以具有表2所列的原子坐标。本发明也提供用此方法获得的晶体化GSK3蛋白质。
在另一方面，提供了一种制造GSK3蛋白复合物的方法。在一实施方式中，此方法包括将可被磷酸化的多肽、腺苷三磷酸、镁盐和GSK3蛋白相混合，来制备包含磷酸化多肽、腺苷二磷酸和GSK3蛋白的GSK3蛋白复合物；该实施方式中，可被磷酸化的多肽可以是单磷酸化多肽。在另一实施方式中，此方法包括将磷酸化多肽、腺苷二磷酸和GSK3蛋白相混合，制备含磷酸化多肽、腺苷二磷酸和GSK3蛋白的GSK3蛋白复合物；该实施方式中，磷酸化多肽可以是二磷酸化多肽。
通过在含有GSK3蛋白复合物的溶液中加入沉淀剂，可从这些复合物中制备出晶体。合适的沉淀剂包括聚乙二醇和2-甲基-2，4-戊二醇。所述的GSK3蛋白可以具有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型，所述的晶体可以具有表2所列的原子坐标。
在本发明另一方面，提供了一种制备含有潜在GSK3介质的GSK3蛋白晶体的方法。在一种实施方式中，所述方法包括使晶体化GSK3蛋白与潜在的GSK3介质接触。该晶体化GSK3蛋白质含有GSK3构建物和磷酸化多肽。本发明也提供此法产生的晶体。
在另一方面，本发明提供了一种提供GSK3蛋白的原子模型的方法。在一种实施方式中，此方法包括以下步骤(a)提供一种计算机可读介质，其上储存有晶体形式GSK3蛋白的原子坐标/x-射线衍射数据，该数据足够模拟GSK3蛋白的三维结构，并且该晶体形式GSK3蛋白质含有GSK3构建物和磷酸化多肽；(b)分析获自(a)的原子坐标/x-射线衍射数据，提供可确定GSK3蛋白原子模型的数据输出；和(c)获得可确定GSK3蛋白三维结构的原子模型输出数据。
本发明也提供其上储存有该方法获得的GSK3蛋白原子模型数据的计算机可读介质，以及GSK3-β配体，其对应于此方法制得的配体模型的原子模型的物理模型。
在另一方面，也提供了一种利用GSK3三元复合物的三维结构，鉴定可能治疗由GSK3活性所介导的各种疾病的治疗化合物的方法。在一种实施方式中，本发明提供了一种设计能结合GSK3蛋白质的配体的方法，该方法包括利用GSK3复合物的某些或所有原子坐标。在一种实施方式中，该方法包括以下步骤(a)使纯化的GSK3蛋白结晶，以提供具有生物活性的晶体化GSK3蛋白质，其中该晶体化GSK3蛋白质含有GSK3构建物和磷酸化多肽；(b)用x-射线晶体学分辨晶体化GSK3蛋白的结构，获得适合于确定GSK3蛋白三维结构的数据；(c)将分辨晶体化GSK3蛋白产生的数据应用于一种计算机算法，以产生GSK3蛋白模型，适用于设计能结合GSK3蛋白活性位点的配体；和(d)运行重复的过程，由此将该分子结构应用于计算机所产生的可鉴定GSK3结合性配体的模型。晶体化GSK3蛋白可以包含表2所列的原子坐标。所述GSK3蛋白可以包含SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。本发明也提供此法设计的GSK结合性配体。
另一方面，本发明提供了一种通过测定潜在的介质和GSK3结合位点之间的结合性相互作用来鉴定GSK3介质的方法，此结合位点由GSK3晶体至少某些原子坐标来确定。在一实施方式中，此方法包括以下步骤(a)在计算机屏幕上产生一个由此结合位点所确定的结合槽穴；(b)产生具有空间结构的化合物；和(c)确定这些化合物是否能结合GSK3的结合位点。本发明还提供一种鉴定能介导GSK3活性的化合物的方法。在一实施方式中，该方法包括以下步骤(a)设计一种潜在的GSK3介质，其能与基于GSK3晶体至少某些原子坐标的GSK3结合位点中的氨基酸形成非共价键；(b)获得该潜在的介质；和(c)确定该潜在的介质是否能介导GSK3活性。在另一实施方式中，该方法包括以下步骤(a)利用GSK3晶体原子坐标所确定的GSK3三维结构，来设计或选择潜在的介质；(b)获得该潜在的介质；和(c)使该潜在的介质与GSK3接触，以确定该潜在的介质是否能介导GSK3活性。
在另一方面，本发明提供了一种可产生分子或分子复合物三维图像的计算机，所述分子或分子复合物包括一个由GSK3晶体至少某些原子坐标所确定的结合槽穴，或可产生所述分子或分子复合物同源物的三维图像的计算机。在一实施方式中，所述计算机包括(a)机器可读数据存储介质，其包含机器可读数据所编码的数据存储材料，所述数据包括GSK3晶体的原子坐标；(b)-内存储器，储藏用于处理机器可读数据的指令；(c)与该内存储器和机器可读数据存储介质相连接的中央处理器，用于将该机器可读数据加工成三维图像；和(d)与中央处理器相连接的显示器，用于显示该三维图像。
本发明还提供一种，用于确定对应于某分子或分子复合物的X-射线衍射模式的至少一部分原子坐标的计算机。在一种实施方式中，该计算机包括(a)一种机器可读数据存储介质，其包含机器可读数据所编码的数据存储材料，其中所述数据包括至少一部分GSK3晶体的原子坐标；(b)一种机器可读数据存储介质，其包含机器可读数据所编码的数据存储材料，其中所述数据包含该分子或分子复合物的X-射线衍射模式；(c)-内存储器，用于储藏处理(a)和(b)的机器可读数据的指令；(d)与内存储器以及(a)和(b)的机器可读数据存储介质相连接的中央处理器，用于执行(a)的机器可读数据的傅立叶转换和将(b)的机器可读数据加工成为结构坐标；和(e)与中央处理器相连接的显示器，用于显示该分子或分子复合物的结构坐标。
附图的简要说明参考下面详细的描述，并结合附图，前面所述的各方面以及本发明所伴随的优点将更容易被理解。
图1是GSK3-β三元复合物的结构图；图2A和2B是含有结合肽的GSK3-β三元复合物活性位点的表面图象；图3A-3C是一种化合物被吸入到GSK3-β活性位点的图象；图4是本发明的一种典型方法的流程图，利用GSK3-β三元复合物的三维结构来鉴定能介导GSK3-β活性的可能的治疗化合物；和图5是本发明的一种典型方法的流程图，利用GSK3-β三元复合物的三维结构来鉴定能介导GSK3-β活性的可能的治疗化合物。
优选实施方式的详细描述根据本发明，提供了一种三元复合物的晶体，其包括含有蛋白催化激酶结构域的人糖原合成酶激酶3-β(GSK3-β)的蛋白构建物、腺苷二磷酸和磷酸化肽。本发明还提供使所述三元复合物结晶的方法；该三元复合物的三维结构；以及利用此三元复合物的三维结构来鉴定可能的治疗化合物，以治疗由GSK3-β活性所介导的各种疾病的方法。
三元复合物GSK-3β构建物、腺苷二磷酸和磷酸化肽本发明的三元复合物包括GSK3-β构建物、腺苷二磷酸和磷酸化肽。所述复合物可以通过将GSK3构建物与腺苷三磷酸(ATP)以及可被GSK-3构建物磷酸化的肽混合而形成。肽磷酸化提供了包含磷酸化肽和腺苷二磷酸(ADP)的复合物。所述复合物也可通过将磷酸化肽和腺苷二磷酸与GSK3-β构建物相混合而形成。
如下所述，该三元复合物的晶体结构显示此磷酸化肽(如二磷酸化肽)跨越晶体中两个对称性相关蛋白质之间的区域，并定位于接受另一丝氨酸残基的位置上。不受理论所束缚，可认为该磷酸化肽能催化此三元复合物的晶体形成。
与其他GSK3晶体相比较，本发明的三元复合物晶体呈现稳定、易于吸入GSK介质中、以及高分辨率的优点。例如，通过《Characterization of the GSK-3βProtein and Methods of USE Thereof》(美国专利申请序列号No.60/233538，2000年9月19日申请；以及PCT/US01/29549，2001年9月19日申请引用于本文作为参考)中所描述的方法获得的晶体，其所提供的晶体在分辨率(最大2.2埃)、数据采集时间(一般为36小时)、以及可被吸入ATP-结合位点的配体的尺寸(大约小于400道尔顿)方面有局限性。本发明的三元复合物晶体在所有这些方面都是优异的最佳分辨率达到2.0埃(可能达到1.8埃)；数据采集时间显著的减少(一般为24小时)；并且对于可被吸入ATP结合位点的配体的尺寸没有可鉴定的限制。
各种候选GSK3介质(即先导化合物)可以被吸入该三元复合物的晶体中，并可确定它们的晶体结构。结果获得的晶体中，先导化合物被吸入而ADP和磷酸化肽被吸出。由于此三维复合物晶体的此种特性，该晶体可容纳相当大的先导化合物，这看来是此晶体结构中肽磷酸化的结果。此三元复合物晶体中酶的结合位点看来没有因晶体包装而被封闭，这与其他已研究过的GSK3晶体不同，它们受到GSK3晶体可容纳的先导化合物的大小和形状的限制。此三元复合物晶体为酶的结合位点提供了相对通畅的通路。加上所述按PCT/US01/29549中描述方法制备的晶体，很难吸入400道尔顿以上大小的化合物，而本发明的晶体可轻易地吸入超过450道尔顿的化合物。
此三维复合物晶体可以被高度分辨(如1.8埃)，同样的，包含酶和候选介质的共同结晶体也可以被高度分辨(如2.6埃或更好)。
如前面所提到的，包含磷酸化肽的此三维复合物可以通过ATP、镁和GSK3构建物的相互作用来制备。所述磷酸化肽可获自可被GSK3构建物磷酸化的肽，合适的能够磷酸化的肽含有可被磷酸化的氨基酸残基，合适的可被磷酸化的残基包括但不限于丝氨酸和苏氨酸。所述磷酸化肽也可获自含有可被磷酸化的氨基酸残基的磷酸化肽(如可磷酸化的单磷酸化以获得二磷酸化肽)。其他合适的肽包括例如可与GSK3构建物结合以制备此复合物的二磷酸化肽。合适的磷酸化多肽包括可跨越晶体中两个对称性相关蛋白质之间的区域，为酶结合位点提供相对通畅的通路的那些肽。合适的肽可以包括大约6至8个氨基酸残基。在一种实施方式中，可用于与ATP和GSK3构建物形成此复合物的磷酸化肽，包括7个氨基酸残基，其中有磷酸丝氨酸残基。在另一种实施方式中，可用于与ATP和GSK3构组合形成此复合物的磷酸化肽包括6个氨基酸残基，其中有磷酸丝氨酸残基。可与ATP和GSK3构组合形成此三元复合物的代表性磷酸化肽，具有序列LSRRPS*Y(SEQ ID NO2)，其中S*代表磷酸丝氨酸。其他的磷酸化肽也是可用的，比如二磷酸化肽以及其他肽，所述的可以被磷酸化的肽可用于制备本发明的三元复合物。
图1是GSK3-β三元复合物的结构图，显示一条多肽与酶相连接。图2A和2b是带有结合多肽的GSK3-β三元复合物活性位点的表面图象。图3A-C是一代表性化合物被吸入GSK3-β三元复合物活性位点中的图解说明，该化合物是 图中显示了化合物与酶的活性位点的相互作用该化合物的氨基-嘧啶基团与接头区形成两条氢键，该化合物的咪唑与β-链区域形成非氢键连接，该化合物的双氯酚基团适合进入激酶催化区域附近的疏水槽究中。吸入了上述化合物的GSB3-β构建物的三维结构的原子坐标列举在表3中。
GSK3-β蛋白构建物表达、纯化和结晶在一方面，本发明提供了一种组合物，它是一种三元复合物，包含GSK3构建物、腺苷二磷酸和磷酸化肽。此GSK3构建物含有蛋白质催化激酶结构域。该构建物包括人GSK3-β中至少第37-384位的残基，并且缺少此蛋白质C-末端的36个氨基酸。该组合物是结晶形式，足以用X-射线衍射研究来进行结构测定。
应注意，GSK3蛋白构建物除了这里描述的以外，还包括例如其活性突变体和变型，可以提供用于鉴定可能用于治疗各种由GSK3活性所介导的疾病的治疗化合物的三维结构信息。
构建物序列。此构建物的序列SEQ ID NO1如下。其中带星号的残基表示在晶体结构中可见的第一个残基。以下的构建物和其他的有用的构建物以及它们的制备在待批美国专利申请序列号No.60/221242(2000年7月27日申请)中所述，其所公开的内容在这里引用作为参考。
N末端MEYMPMEGGGGSK*VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIC-末端(SEQ ID NO1)构建物的纯化。GSK3-β蛋白构建物是从感染了携带GSK3-β580cDNA构建物的杆状病毒的SF-9细胞中抽提得到的。用S-Fractogel，Phenyl-650M，以及Glu-tag亲和层析，纯化GSK3-β蛋白构建物至表观同质。然后将纯化的蛋白浓缩以便进行结晶，此构建物的纯化方法在实施例1中描述。
构建物的结晶。可采用悬滴技术从含GSK3构建物的溶液形成蛋白质晶体。实施例2中描述了代表性的GSK3构建物晶体的制备方法，可获得适用于结构测定的晶体。
应注意，各种结晶方法，包括例如微晶化方法，都可用获得有用的三维结构信息，以鉴定可治疗由GSK3活性所介导的各种疾病的治疗化合物。
GSK3-β蛋白质构建物的结构在本发明的另一方面，提供了GSK3三元复合物的三维结构。将氨基酸序列数据和获自X射线衍射数据的原子坐标应用于确定该构建物的三维结构。此构建物的原子坐标可从X射线衍射和相位数据结合所产生的电子密度图计算获得。
对适合于结构测定的晶体形式GSK3三元复合物来说，其晶体结构可通过多种技术来获得。在一种典型的方法中，使用X射线图象板装置获得衍射模式，然后通过分子置换获得相位数据，制作电子密度图，分辨其结构并且建立分子，精细化所得结构和验证该结构，最终结果是GSK3构建物的原子模型。实施例3中描述了获得GSK3晶体结构的典型方法。
应注意，GSK3结构可以通过多种方法来分辨。
表1小结了采集晶体图样数据的统计。
表1.用于结构分辨的数据和模型统计
GSK3-β三元复合物三维结构的原子坐标列表见表2。在表2中，“OH2”指结构性水分子，“TER”指肽链末端。
基于此衍生晶体结构的GSK3-β三元复合物的三维结构见图1所示，该三元复合物包括N-末端和C-末端结构域以及这两个结构域之间形成的活性位点。N-末端结构域含有一β-桶结构，此活性位点区域包括ATP结合位点、镁结合/催化基础位点和底物结合位点。
基于此衍生晶体结构的GSK3-β三元复合物的活性位点(包括催化位点和底物结合位点)的三维结构见图2A和2B。该活性位点的氨基酸残基中包括Pro136和Phe67。
磷酸化肽的相互作用区域位于酶的底物结合区域中，而不是在ATP结合位点(大多数先导药物化合物的作用位点)中。可以认为在该晶体矩阵中既在肽和酶之间又在肽和酶的对称配对物之间发生此种相互作用，这样形成了更优形式的晶体。肽与酶的相互作用是变化的。关键性相互作用的第一步是磷酸化肽的N-末端磷酸丝氨酸通过氢键与Arg-96(一种静电反应)和Val-214’的主链酰胺相互反应。关键性相互作用的第二步是肽的第二个精氨酸(靠近C-末端)与邻近的酶的对称配对物形成关键的静电反应，即与Pro-258的主链羰基和侧链Asp-260’(右上角标记符号表示对称配对物)反应。该肽还可与酶及临近的对称配对物发生其他一些次要的疏水反应。
脱辅基蛋白活性位点的结构信息可以为配体的推理设计提供基础，以设计出对治疗由GSK3-β活性所介导的各种疾病有效的治疗化合物。因此，从晶体学数据获得的结构信息可用于开发配体的概，和推理设计介导下述GSK3-β活性的药物。
GSK3结构图像。前已述及，本发明的一个方面是提供一种方法，用于鉴定对治疗GSK3-β活性所介导的各种疾病有效的治疗化合物。此方法涉及利用GSK三元复合物的三维结构图像，该三维结构图像可以包括(a)完整的GSK构建物，(b)包含GSK构建物的GSK3片断，或(c)包含可与介导GSK3活性的配体相互反应的氨基酸的GSK构建物片断。
此结构图优选基于或衍生自表2所列的原子坐标，其代表了完整的GSK构建物的结构。合适的结构图包括衍生自这些原子坐标的三维模型和分子表面。表2的坐标包括结构性水分子。它们在其他的模型结构中可能不同，甚至缺失(它们是溶液和空间群依赖的)。这些溶剂分子在不同的晶体中是不同的。
表2所列的原子坐标的变型也可用作本发明，比如与表2所列原子坐标相比，所有重(即非氢)原子的x、y和z坐标发生RMS偏离不到低于约2.5_，例如不到2_，优选不到1_，更优选不到约0.5_，或最优选不到0.1_)的变型。坐标发生转化但是留了原子的三维空间关系也可用作为合适的变型。
这里提供的原子坐标也可用作下一步蛋白质结构模型的基础。例如，基于该GSK构建物结构的同源模型。所述坐标也可用于分辨或进一步的GSK3晶体结构(如与新的配体共同结晶的结构)精细化。
GSK3结构图的存储介质。可将GSK三元复合物的原子坐标储藏在一介质上，便于之后在计算设备如计算机(如超型计算机、大型机、小型机或微型处理器)上的使用。通常，将这些坐标储藏在可容纳大量数据的介质上，如磁或光介质(如软盘、硬盘、光盘、磁光介质(“可光读的”软磁盘，或磁带)或电子介质(如随机存储器(RAM)，或只读存储器(ROM))。此存储介质可装在该计算机中，或可远程使用(如网络存储介质，包括英特网)。计算机、存储介质、网络以及其他设备或技术的选择，是结构/计算机化学领域的技术人员来所熟悉的。
本发明也提供计算机可读介质，其含有此GSK三元复合物的原子坐标和/或三维结构图。原子坐标优选表2所列的那些或它们的变体。任何合适的计算机都可用于本发明。
GSK3-β配体的概貌(profile)的建立。前已述及，从晶体学数据获得的结构信息可用于建立配体的概貌图，以推理性设计可介导GSK3-β活性的化合物。配体的概貌可以根据上述脱辅基蛋白的结构信息来建立。伴随着带结合配体的蛋白质其他结构的确定，此配体概貌可进一步发展和精细化。最后获得的配体概貌能鉴定可介导GSK3-β活性的治疗化合物。
此配体的概貌可能主要根据配体和蛋白配体结合位点之间的形态相互作用(shape-interaction)而定。形态相互作用的评估包括考虑配体的构象特性，依据它们达到与配体结合位点相容的低能构象能力来评定等级。形状相互作用也可寻求使配体和结合位点之间的焓相互作用达到最大化。
建立配体概貌的方法是可有种多样，比如该概貌可以由专家通过活性位点结构的视觉观察来建立。这种观察可包括对结合位点、配体结构和化合物数据库检索的综合考虑。概貌的建立也可既考虑生物学数据和结构活性的关系(SAR)，又考虑已知的配体与其他相似蛋白质的结合性相互作用。
不管怎样，配体概貌是通过考虑配体结合相互反应而建立，包括主要和次要相互反应，结果应确定出药效团。“药效团”指一种化学特征和三维限定的总和，代表导致配体活性的具体特征。药效团包括表面进入特征，氢键供体和受体、带电/可电离的基团、和/或疏水小片等特征。
除上述的配体概貌建立过程，其他以结构为基础的药物设计技术也能应用于产生GSK3构建物的结构图像，以鉴定能与GSK3相互作用而介导GSK3活性的化合物。多种合适的技术是本领域普通技术人员可利用的。
执行分子模拟技术用于以结构为基础的药物设计的软件包，包括SYBER(获自Tripo公司，http//www/trips.com)；AMBER(获自Qxford Molecular，http//www/oxmol.co.uk/)；CERIUS2(获自Molecular Simulations公司，http//www/msn.com/)；INSIGHT II(获自Molecular Simulations公司，http//www/msn.com/)；CATALYST(获自Molecular Simulations公司，http//www/msn.com/)；QUANTA(获自Molecular Simulations公司，http//www/msn.com/)；HYPERCHEM(获自Hypercube公司，http//www/hyper.com/)；FIRST DISCOVERY(获自Schrodinger公司，http//www/Schrodinger.com)；MOE(获自Chemical Computer集团，http//www/chemcomp.com)和CHEMSITE(获自Pyramid Learning，http//www/chemsite.org/)。
可使用模拟软件来确定GSK3结合表面并且显示其特性，如范德瓦尔斯(van derwaals)接触、静电相互反应，和/或氢键作用。这些结合表面可用于模拟配体停靠在GSK3上，以达到药效团假定，和重新设计可能的治疗化合物。
GSK3-β配体的有效筛选脱辅基蛋白的三维结构，尤其是蛋白质活性位点的结构，可以确定能进入该活性位点的合适化合物。利用一种快速停靠程序，可评估比如某化合物数据库中的各种化合物的活性位点结合。可评估具体化合物是否合适。然后设定一评分域值可获得一组化合物作为有效筛选的解决方法。
在第一级水平，所述的有效筛选要考虑脱辅基蛋白活性位点的三维结构。在第二级水平，有效筛选要考虑配体的概貌，并可利用结合有配体的蛋白质结构测定中获得的信息。即使没有结合配体的结构信息，有效筛选也是可进行的。
从有效筛选中获得的信息可考虑用于进一步建立该配体的概貌。或者，当有效筛选的结果表明是一种具有前景的化合物，可获得该化合物并进行相关生物活性的筛检。
停靠(docking)。停靠指一种过程，此过程中两个或多个分子基于能量的不同而排列。停靠使两个或多个分子以三维结构而排列，从而可预测这些分子所形成的复合物的构象(参见如Blaney&Dixon，Perspectives in Drug Discovery andDesign 1301，1993)。在本发明的实施中，分子停靠在GSK3构建物结构上，可评估它们与GSK3相互反应的能力。
停靠可通过配体与其受体的几何匹配或通过将相互反应能量最小化而完成。几何匹配算法是优选的，因为其相对快速。
合适的停靠算法包括DOCK(Kuntz等，J.Mol.Biol.161269-288，1982，获自UCSF)，它是最典型的以结构为基础的药物设计程序；AUTODOCK(Goodsell & Olson，ProteinsStrcture，Function and Genetics 8195-202，1990，获自OxfordMolecular，http//www/oxmol.co.uk/)，其以可屈曲的方式使配体停靠到受体，利用基于网格的蒙特卡洛(Monte Carlo)模拟退火。AUTODOCK程序的可屈曲特性有助于避免因用户搜索者(Meyer等，Persp.Drug Disc.3168-95，1995)所引入的偏差(如配体活性位点的取向和构象中的偏差)，因为刚性停靠中的起始构象通常向配体的最小能量构象偏移，而该结合构象可以有相对高的构象能量(Nicklaus等，Bioorganic & Medicinal Chemistry 3411，1995)。
其他合适的停靠算法包括MOE-DOCK(获自Chemical Computer集团公司，http//www/chemcomp.com)，其中用模拟退火搜索算法使停靠配体可屈曲，并用基于网格的能量评估给已停靠的构象评分；FLExX(获自Tripo公司，http//www/trips.com)，其采用步进结构算法将构象可屈曲的配体停靠在结合位点，使配体结合而该位点中，并且根据配体-受体相互反应的力量来评估停靠的构象；GOLD(Jones等，J.Mol.Biol.267727-748，1997)，一种用于可屈曲配体停靠的遗传学算法，具有全部配体和部分蛋白质的可屈曲性，其能量功能部分依据构象和非键合接触信息；AFFINITY(自Molecular Simulations公司，http//www/msn.com/)，其采用两步法停靠配体首先，用Monto Carlo型方法搜索构象和笛卡尔空间，获得受体中配体的初始位置；第二，模拟退火相位可优化每个配体位置的定位，在该相位中，AFFINITY持有该受体的“大部分(bulk)”(不在结合位点的原子)的刚性，而结合位点原子和配体原子是可活动的；C2LigandFit(获自MolecularSimulations公司，http//www/msn.com/)，其利用配体-受体复合物的能量得自动寻找最佳的结合模式，并用随机构象搜索技术，从构象取样中获得的最佳结果被保留。采用一种网格方法评价刚性受体和柔性配体原子之间的非键合相互反应。DOCKIT(获自Metaphorics LLC)，利用距离几何来加快柔性的配体停靠。GLIDE(获自Schrodinger公司)，采用预先计算的能量网格和有效删改的系统搜索来可曲的停靠。
优选采用高通量模式的停靠算法，此法对潜在配体巨大结构库中的各成员进行筛检是否有此受体结构(Martin，J.Med.Chem.352145-54，1992)。
合适的结构库包括ACD(Avaikble Chemical Directory获自MDL公司)，AsInEx，Bionet，CmGenex thd Derwent世界药物索引(WDI)，接触服务公司数据库(ContactService Company Database)，Labo Test，ChemBridge Express Pick，ChemStar，BioByteMasterFile，Orion，SALOR，TRIAD，ILIAD，国家癌症研究院数据库(NCI)，以及Aldrich、Fluka、Sigma和Maybridge目录。这些都是商品化可得到的结构库(如Oxford Molecular的HTS化学库，或Tripos的LeadQuestTM文献)。
确定药效团。前已述及，可以确定GSK3三元复合物的药效团，其包括表面可进入特征，氢键供体和受体、带电/可电离基团、和/或疏水小片等特征。可依据其赋予活性的相对重要程度来衡量这些特征(参见如Computer-Assisted LeadFinding and Optimization，Testra&Folkers，1997)。
药效团可以用一些软件来确定，比如CATALYST(包括HypoGen或HipHop，获自Molecular Simulations公司，http//www/msn.com/)，CERIUS2，或从先导化合物已知的构象中通过手工构建。采用如CATALYST之类的程序，药效团可用于筛选结构库。也可采用CLIX程序(Davic & Lawrence，Proteins 1231-41，1992)，其搜索结构库中候选分子的取向，形成容纳与受体相互反应的化学基团最大空间。DISCO程序(获自Tripos)采用一种小集团检测方法，鉴定各结构的共同药效特性，产生最优化的排列结构，并找出药效团的关键特性。GASP程序(获自Tripos)采用一种遗传学算法得自动寻找具有构象可弯曲性的药效团。
重新设计化合物。可用GSK3三元复合物的结合表面或药效团来作图显示功能基团(如质子、羟基、氨基、酸性基团、疏水基团和/或二价阳离子)或小分子片断的有利相互反应位置。然后可进行化合物的重新设计，使其中的相关功能基团位于可与GSK3相互反应的正确的空间相关位置中。
一旦鉴定到可与GSK3结合表面上特异位点反应的功能基团或小分子片断，可将它们连接到一种化合物中，可采用具有正确大小和几何形状的连接片断，或可采用能支持功能基团采取有利取向的框架结构，从而提供本发明的化合物。使用这种方式的功能基团的连接可以手工进行，或借助软件如QUANTA或SYBYL进行；功能基团的连接也可用自动或半-自动的重新设计方法。
合适的重新设计软件包括MCDLNG(Gehlhaar等，J.Med.Chem.38466-72，1995)，其在受体结合位点装填有紧密的普通原子阵列，和采用Monto Carlo方法随机变换原子类型、位置、链连安排和其他特性；MCSS/HOOK(Calfish等，J.Med.Chem.362142-67，1993；Eisen等，ProteinsStr Funct.Cenet.19199-221，1994；获自Molecular Simulations公司，http//www/msn.com/)，其将多个功能基团与获自数据库的分子模板进行连接；LUDI(Bohm，J.Comp.Aided Molec.Design661-78，1992，获自Molecular Simulations公司，http//www/msn.com/)，其计算能理想地被配体充满的相互反应点，根据诸片断与受体反应的能力将它们置于结合位点中，然后将它们连接，生成配体；GROW(Moon和Howe，ProteinsStr.Funct.Genet.11314-328，1991)，其起始于一种初始“种子”片断(人工或自动放置)，向外生长形成配体；SPROUT(获自http//chem.leeds.ac.uk/ICAMS/SPROUT.html)，其包括可鉴定有利的氢键结合的和结合槽穴中疏水区域的分子(HIPPO模块)，选择功能基团并将它们置于靶位点，形成结构生成(EleFanT)的起始片断，通过生成在此起始片断上分隔片断、然后连接产生的骨架部分(SPIDeR)，产生能满足此结合槽穴空间限制要求的骨架，将异原子替换入此骨架产生与受体位点互补的具有静电特性的分子(MARABOU)，可用ALLigaTOR模块群集诸分辨率和评分；LEAPFROG(获自Tripo公司，http//www/trips.com)，其通过进行小的逐步结构改变和快速评价新化合物结合能量的方法评价配体，根据改变的结合能确定将其保持或丢弃，获得能提高与受体相互反应能的结构；GROUPBUILD(Rorstein等，J.Med.Chem.361700，1993)，其采用共同的有机模板库和配体与受体之间非键合反应的完全经验力场图像，构建具有化学上合理的结构以及具有与该受体结合位点相匹配的空间和静电学特性的配体；CAVEAT(Lauri和Batelett，Comp.Aided.Mol.Design 851-66，1994)，其设计连接单位以约束无环分子；以及RASSE(Lai，J.Chem.Inf.Comput.Sci.361187-1194，1996)。
GSK3-β配体大多数启动基于结构的设计循环的先导化合物可通过高通量筛选鉴定。作为上高通量筛选、配体概貌和有效筛选的结果，鉴定具有所需构象能量的配体以采取适当的形状并与蛋白质的活性位点结合。除了具有低的构象能量和与脱辅基蛋白活性位点的空间相容性外，所鉴定的配体优选综合考虑可进入的。然后可获得所鉴定的配体(如从市场上获得或合成)并对其作生物学活性筛选。所鉴定的配体也可以与该蛋白质构建物共同结晶，测定带结合配体的蛋白质的三维结构。从带有结合配体的蛋白的结构中获得的信息可以用于更进一步发展上述的配体概貌。
评价配体生物活性的合适的GSK3-β的生物学筛选方法是已知的，包括例如美国专利申请序列号No.60/193,043(2000年3月29日申请)中描述的，本文引用其全部内容作为参考。
利用GSK3晶体结构发现合理的药物的方法在另一方面，本发明提供了一种利用GSK3晶体结构，具体是GSK3构建物上活性位点的三维结构，来设计可结合GSB3-β并介导活性的配体的方法。
在一种实施方式中，此法是一种重复进行的基于结构的方法，用于治疗化合物的设计。图4流程图描述了一种典型的方法。参见图4所示，在102和104步骤中分别确定了脱辅基蛋白和带有结合配体的蛋白质的晶体结构。在106步骤中，利用102和104步骤中获得的结构信息建立了配体概貌图。配体概貌也可以直接从脱辅基蛋白的晶体结构产生。在108步骤中，利用所获得的配体概貌，可以设计和/或获得新的配体，进行生物活性筛选和/或与此蛋白质共同结晶。或者，配体概貌可用于步骤110中的有效筛选。如果从已建立的概貌获得配体被共同结晶，其共结晶晶体的结构在步骤104中确定，其产生的结构信息在106步骤中用于进一步发展此配体概貌。如果利用该配体概貌在步骤110中作有效筛选，此有效筛选或成功鉴定到在步骤108中获得的、筛选的和/或共同结晶的一个配体、或多个配体。如果此种筛选没有成功地鉴定到合适的配体，则可在106步中进一步建立此配体概貌。
可从配体概貌所建立的配体的生物筛选中被鉴定到先导化合物。图5流程图描述了一种鉴定先导化合物的典型方法。参见图5，在202和204步骤中分别确定了脱辅基蛋白和带有结合配体的蛋白质的晶体结构。在206步骤中，利用202和204步骤中获得的结构信息建立了配体概貌图。配体概貌也可以直接从脱辅基蛋白的晶体结构产生。在208步骤中，利用所获得的概貌可设计和/或获得新的配体，然后可在步骤210中进行生物活性筛选，和/或在步骤212中进行共同结晶。如果生物活性筛选成功，则可在步骤214中鉴定到先导化合物，在随后的重复中，可在步骤212中共结晶此先导化合物并继续重复直到鉴定到新的候选药物。如果生物筛选不成功，可利用此信息在步骤206中进一步发展此配体概貌。如果配体被共同结晶，可在204步骤中确定该共同结晶的结构，并且其结构信息可用于在步骤206中进一步发展此配体概貌。
或者，可在步骤216中，利用该配体概貌的结果作有效筛选。如果有效筛选成功并鉴定到一个或多个配体，可以在208步骤中获得配体和在210步骤中筛选，以确定其生物活性以及是否是已经鉴定到先导化合物。步骤208中获得的配体也能在步骤212中被共同结晶并且其确定的结构和产生的信息可用于进一步发展此配体概貌。如果此种筛选没有成功地鉴定到合适的配体，可在步骤206中进行进一步发展此配体概貌。
GSK3配体和它们的用途本发明的方法可鉴定能与GSK3相互作用的配体，这些化合物可重新设计，可以是已知的化合物，或可根据已知的化合物设计。所述化合物本身可作为有用的药物，或可以作为药物原型用于进一步药物精炼(即作为先导化合物)，以提高结合亲和力或其他药学上重要的特性(如生物可利用度、毒理学、新陈代谢、药代动力学)。
因此本发明另一方面提供了(1)采用本发明方法鉴定到的化合物；(2)采用本发明方法鉴定的化合物用作药物；(3)采用本发明方法鉴定的化合物在制造介导GSK3活性的药物中的应用；和(4)一种治疗患有因GSK3活性所介导疾病的病人的方法，包括给予一定量的采用本发明方法的能有效介导GSK3活性的化合物。
这些化合物与GSK3相互作用的结合范围限制优选微摩尔级，更优选毫微摩尔级或更强。
作为有用的化合物，也可利用基于结构的设计技术所鉴定的配体来提示传统的体内或体外筛选方法的化合物库。可鉴定到配体中的重要药物基序并在化合物库(如组合库)中模拟以筛检GSK3结合活性。
结合以下代表性实施例，对本发明上述的以及其他方面的内容将会有更好的理解。
实施例实施例1GSK3-β构建物的纯化在本实施例中，描述了GSK3-β蛋白构建物的纯化。此构建物从转染了含GSK3-β580cDNA的杆状病毒的SF-9细胞中抽提获得，采用S-Fractogel，Phenyl-650M，以及Glu-tag亲和层析，纯化至表观同质，过程描述如下抽提。将感染的SF-9细胞的20升发酵产物的细胞糊用100ml PBS(10mM Napi，pH7.5，150mM NaCl)洗涤，然后重新悬浮于300ml缓冲液H(20mM Tris，pH7.5，1mM钨酸盐，1mM砒酸盐，50mM DTT，10μg/ml亮抑蛋白酶肽，1μg/ml抑肽素A，10％甘油，0.35％辛基糖苷，1mM Mg2+)中。细胞在100ml杜恩斯匀浆器(用研杵B研磨20下)中匀浆化。合并的匀浆在Ti45转子中以40,000rpm的速度离心35分钟，以去除细胞碎片和细胞核。小心地将离心获得的上清液移出并通过0.45μ滤器过滤。
S-Fractogel亲和层析。将175ml S-Fractogel(EM科学，Cat#18882)装入5cm×8.9cm的层析柱中，用5倍柱体积的缓冲液A(20mM Tris，pH7.5，10％甘油)平衡。在加入过滤的上清之前，先用1倍柱体积的含50mM DTT的缓冲液A过此平衡柱。然后将前一步的上清液以20mL/min速度加到柱中。分别用3倍柱体积的含50mM DTT的缓冲液a和2倍柱体积的缓冲液A洗柱，然后用20倍以上柱体积的含O-1M NaCl的缓冲液A进行线性梯度洗脱，洗脱液分成20ml的各组分。含有GSK3的组分用抗GSK抗体(Santa Cruz Biotech，Cat#SC-7291)通过Western印染检测。合并Western印染阳性的组分，与相同体积的缓冲液M(20mM Tris，pH7.5，10％甘油，3.1M NaCl)混合，并通过0.45μ滤器过滤。过滤液用于后续Phenyl-650M层析。
Phenyl-650M层析。将37.5ml Phenyl-650 M(Tosohass，Cat#014943)装入2.2×10cm的柱中，用5倍柱体积的缓冲液C(20mM Tris，pH7.5，10％甘油，1.6M NaCl)平衡，将S-fractogel步骤获得的滤液以7.5mL/min的速度加入。加样结束后用5倍柱体积的缓冲液C洗涤此柱，用20倍以上柱体积的0％-100％的缓冲液A(20mMTris，pH7.5，10％甘油)进行线性梯度洗脱。收集各15ml的组分，含有GSK的组分用抗GSK抗体通过Western印染检测。合并Western阳性的组分，加到Glu-tag抗体亲和柱上。
Glu-tag亲和层析。将50mg的Glu-tag抗体固定到28ml的Affi-Gel 10上(BioRAD，Cat#153-6046)并装入2.2×6.5cm的柱中。用5倍柱体积的缓冲液D(20mMTris，pH7.5，20％甘油，0.3MNaCl，0.2％辛基糖苷)平衡此魔王，将Phenyl-650M步骤获得的组分合并液以2.8ml/min加入。加样结束后用5倍柱体积的缓冲液D洗涤，然后用100ml含Glu-tag肽(100μg/ml)的缓冲液D洗脱，分成各4ml组分。含有GSK的组分用SDS-PAGE和考马斯兰印迹检测。合并含GSK的组分，进行浓缩和缓冲液d透析，用10k MWCO YM10膜，在Amicon浓缩器中浓缩至大约4.8mg/ml。浓缩产物可用于之后的结晶。
实施例2GSK3-β构建物的结晶在本实施例中，描述了GSK3-β三元复合物的结晶。
将含100mM七肽(N-LSRRPS*Y-C，购自Research Genetics)、20mM ATP，100mMMgCl2，和100mM Tris-HCl，pH7.5的溶液与标准储存缓冲液配的GSK-β蛋白溶液以1∶10的比率(v∶v)混合。所用GSK3-β蛋白溶液中，GSK3-β蛋白为4.8mg/ml，以含1×TBS，300mMNaCl，20％甘油，0.2％(v∶v)辛基糖苷和5mMDDT的储存缓冲液配制。上述混合溶液在4℃冰水中孵育2小时。孵育后，用悬滴法来制备结晶滴。在linbro培养板的储存池中加入沉淀溶液，形成二维格阵，此沉淀溶液含7-12％(w∶v)PEG6000和5-8％MPD(v∶v)，以100mM HEPES、pH7.5作为缓冲剂。将该蛋白溶液(2μl)与2μl储存池中的沉淀溶液在玻璃盖玻片上混合，然后将盖玻片覆盖到储存池孔上。三元晶体过夜生长，在四天后达到最大，这些晶体以标准的GSK3-β冷冻溶液低温保藏。结果获得的晶体以单体不对称单位生长在P21空间群中，并且具有大约以下参数的单位晶胞a＝57.0_，b＝64.8_，c＝57.2_，α＝γ＝90°，β＝100.9°。这些晶体对于室内X射线源的衍射好于2.2_，对同步加速器光束的衍射好于2.0_。应注意，确实呈形成此三元复合物的肽是二磷酸化肽，其必然会在孵育阶段的酶反应中形成。
将晶体转移到含5μl储存孔溶液(见以上)和1mM(或其他适当的浓度)先导化合物的液滴中，12-24小时，很容易地实现了用于药物发现的化合物吸入。在该时间内，ADP和肽从晶体中吸出来而先导化合物被吸入，这降低了晶体可能衍射某些光波(至大约2.5埃)的分辨率，使该化合物的结构得到快速确定。这些晶体似乎不受化合物吸入所引起的改变的干扰。
可以低温保护这些晶体，进行数据采集冻存液含12％PEG6000，11％MPD，0.1M HEPES pH7.5，20％甘油。该冻存液可包括大约10-14％重量的聚乙二醇(PEG6000)、大约9-13％重量的2-甲基-2，4戊二醇(MPD)，以及大约18-22％重量的甘油。该冻存液的pH约7.3至7.7。
实施例3GSK3-β三元复合物晶体结构的分辨在本实施例中，描述了分辨GSK3-β三元复合物晶体结构的方法。
采用C222(1)晶体结构(参见PCT/US01/29549)和程序EPMR(Kissinger，et al.，“Rapid Automated Molecular Replacement By Evolutionary Search”，Acta CrystallogrD Biol Crystallogr.55(Pt2)484-91，1999)获得了GSK3-β三元复合物的晶体结构。然后通过多轮精细化大循环进行分辨。典型的精细化大循环包括100-200轮的共轭梯度最小化，用扭转或笛卡儿动力学模拟退火，并作分组或单独的温度因素计算。所有的精细化程序采用程序CNX(Molecular Simulation公司)进行。接着进行新的电子密度图计算，以及根据这些图中的特性，用程序O(DATAONO AB)进行此模型的人工重建。利用数据组中所有50_-2.0_的数据。应注意，此结构的大部分与PCT/US01/29549中描述的GSK3-β晶体形式非常相似。在第一轮精细分辨后，将ADP和肽加入到此电子密度图中。此结构通过多轮的精细化分辨，在程序会聚到R-因子(R-factor)25.1和R-游离(R-free)31.9之前，加入235结构水，以获得50.0-2.0埃的所有数据。
更多的传统方法，如单一/多重同晶替换、或自身的MAD时相或与分子替换相结合都可同样使用。这些方法的描述以及其他晶体学原理可参见Shoichet，B.K.和D.E.Bussiere，“The Role of Marcomolecular Crystallography and Structure For DrugDiscovery”Advances and Caveat，Current Opinion in Drug Discovery & Development3(4)408-422，2000。
GSK3-β三元复合物和吸入了代表性化合物的GSK3-β构建物的原子坐标，分别列在表2和表3中。应知道，水的位置在不同的晶体中是不同的。
表2注释 精细化分辨率50.0-2.0_注释 起始r＝0.2516游离_r＝0.3216注释 最终r＝0.2511游离_r＝0.3191注释 Brmsd对于键连的主链原子＝1.738靶点＝1.5注释 Brmsd对于键连的侧链原子＝2.030靶点＝2.0注释 rmsd对于角主链原子＝2.977靶点＝2.0注释 rmsd对于角侧链原子＝3.170靶点＝2.5注释 wa＝275140注释 rweight＝7.340273E-02注释 目标＝残留步骤＝50注释 sg＝P2(1)a＝57.011 b＝64.769 c＝57.212 α＝90 β＝100.931 γ＝90注释 参数文件1MSI_CNX_TOPPARProtein.param注释 参数文件2ptr.par注释 参数文件3../pagtp_10mM/Model/sep.par注释 参数文件4MSI_CNX_TOPPARwater_rep.param注释 参数文件5../pgatp_10mM/adp.par注释 分子结构文件water_pick2_hr1.psf注释 输入坐标water_pick2_hr1.pdb注释 反射文件＝pagatp_complex_amalgam_hires.fob.cv注释 ncs＝无注释 B-纠正率6.0-2.0注释 起始B-因子纠正用于fobs注释 B11＝9.519 B22＝9.818 B33＝-19.337注释 B12＝0.000 B13＝2.929 B23＝0.000注释 B-因子纠正用于坐标阵列B1.058注释 大量分辨(光罩)密度水平＝0.288754e/A^3，B-因子＝35.9759A^2
注释 反射|Fobs|/∑_F＜0.0被排斥注释 反射|Fobs|＞10000*rms(Fobs)被排斥注释 分辨范围中refl.的理论总数27787(100.0％)注释 未观测到反射的数量(未进入或|F|＝0)674(2.4％)注释 反射被排斥的数量0(0.0％)注释 反射被利用的总数27113(97.6％)注释 工作状态反射数量25794(92.8％)注释 测试状态反射数量1319(4.7％)注释 由CNX VERSION记录2000原子1 CB VAL A 37 52.964 39.855 11.567 1.00 62.47 A C原子2 CG1 VAL A 37 52.434 40.879 10.550 1.00 62.00 A C原子3 CG2 VAL A 37 53.806 38.778 10.891 1.00 63.77 A C原子4 C VAL A 37 53.071 41.785 13.164 1.00 63.31 A C原子5 O VAL A 37 52.166 41.687 14.001 1.00 62.97 A O原子6 N VAL A 37 54.231 39.594 13.697 1.00 62.28 A N原子7 CA VAL A 37 53.808 40.551 12.630 1.00 63.03 A C原子8-N THR A 38 53.417 42.936 12.594 1.00 64.28 A N原子9 CA THR A 38 52.886 44.227 13.022 1.00 65.25 A C原子10 CB THR A 38 54.050 45.289 13.025 1.00 66.02 A C原子11 OG1 THR A 38 53.589 46.538 13.553 1.00 66.31 A O原子12 CG2 THR A 38 54.626 45.492 11.609 1.00 67.12 A C原子13 C THR A 38 51.616 44.775 12.337 1.00 65.20 A C原子14 O THR A 38 51.400 44.587 11.134 1.00 64.53 A O原子15 N THR A 39 50.753 45.392 13.152 1.00 66.00 A N原子16 CA THR A 39 49.497 46.004 12.707 1.00 68.03 A C原子17 CB THR A 39 48.231 45.113 12.996 1.00 68.50 A C原子18 OG1 THR A 39 47.630 45.508 14.236 1.00 66.42 A O原子19 CG2 THR A 39 48.576 43.635 13.046 1.00 68.42 A C原子20 C THR A 39 49.318 47.348 13.438 1.00 69.40 A C
原子21 O THR A 39 49.676 47.467 14.611 1.00 68.70 A O原子22 N VAL A 40 48.723 48.331 12.752 1.00 71.80 A N原子23 CA VAL A 40 48.500 49.684 13.293 1.00 72.99 A C原子24 CB VAL A 40 49.391 50.740 12.526 1.00 73.77 A C原子25 CG1 VAL A 40 50.875 50.368 12.606 1.00 72.91 A C原子26 CG2 VAL A 40 48.964 50.846 11.060 1.00 74.75 A C原子27 C VAL A 40 47.019 50.144 13.245 1.00 72.92 A C原子28 O VAL A 40 46.300 49.852 12.273 1.00 73.69 A O原子29 N VAL A 41 46.583 50.870 14.286 1.00 72.36 A N原子30 CA VAL A 41 45.203 51.402 14.388 1.00 71.35 A C原子31 CB VAL A 41 44.275 50.464 15.202 1.00 71.28 A C原子32 CG1 VAL A 41 43.862 49.270 14.371 1.00 70.39 A C原子33 CG2 VAL A 41 44.970 50.010 16.476 1.00 70.96 A C原子34 C VAL A 41 45.099 52.808 15.017 1.00 70.96 A C原子35 O VAL A 41 46.100 53.500 15.194 1.00 71.36 A O原子36 N ALA A 42 43.873 53.236 15.314 1.00 70.30 A N原子37 CA ALA A 42 43.627 54.540 15.932 1.00 70.21 A C原子38 CB ALA A 42 43.279 55.593 14.876 1.00 69.83 A C原子39 C ALA A 42 42.473 54.364 16.911 1.00 70.35 A C原子40 O ALA A 42 41.398 53.894 16.528 1.00 69.05 A O原子41 N THR A 43 42.709 54.742 18.171 1.00 70.96 A N原子42 CA THR A 43 41.711 54.605 19.248 1.00 71.53 A C原子43 CB THR A 43 41.821 53.234 19.884 1.00 72.10 A C原子44 OG1 THR A 43 41.161 53.253 21.157 1.00 74.61 A O原子45 CG2 THR A 43 43.297 52.873 20.061 1.00 72.38 A C原子46 C THR A 43 41.874 55.627 20.382 1.00 70.59 A C原子47 0 THR A 43 42.986 56.095 20.618 1.00 71.06 A O原子48 N PRO A 44 40.772 55.939 21.121 1.00 69.22 A N
原子49 CD PRO A 44 39.430 55.601 20.625 1.00 68.67 A C原子50 CA PRO A 44 40.650 56.884 22.253 1.00 68.74 A C原子51 CB PRO A 44 39.142 57.190 22.279 1.00 68.39 A C原子52 CG PRO A 44 38.682 56.874 20.900 1.00 68.54 A C原子53 C PRO A 44 41.144 56.510 23.669 1.00 68.26 A C原子54 O PRO A 44 42.110 57.082 24.176 1.00 66.74 A O原子55 N GLY A 45 40.389 55.657 24.349 1.00 69.08 A N原子56 CA GLY A 45 40.756 55.258 25.693 1.00 70.50 A C原子57 C GLY A 45 39.875 55.865 26.769 1.00 72.53 A C原子58 O GLY A 45 38.911 56.571 26.465 1.00 72.84 A O原子59 N GLN A 46 40.204 55.588 28.030 1.00 75.01 A N原子60 CA GLN A 46 39.440 56.107 29.168 1.00 77.46 A C原子61 CB GLN A 46 39.478 55.106 30.327 1.00 77.83 A C原子62 CG GLN A 46 38.473 55.393 31.434 1.00 76.50 A C原子63 CD GLN A 46 38.925 54.871 32.799 1.00 75.55 A C原子64 OE1 GLN A 46 38.426 55.312 33.842 1.00 71.80 A O原子65 NE2 GLN A 46 39.879 53.937 32.796 1.00 75.03 A N原子66 C GLN A 46 39.906 57.499 29.651 1.00 79.37 A C原子67 O GLN A 46 39.247 58.126 30.481 1.00 78.65 A O原子68 N GLY A 47 41.061 57.955 29.166 1.00 81.96 A N原子69 CA GLY A 47 41.562 59.273 29.536 1.00 85.04 A C原子70 C GLY A 47 40.897 60.356 28.687 1.00 87.64 A C原子71 O GLY A 47 39.686 60.284 28.448 1.00 88.30 A O原子72 N PRO A 48 41.649 61.376 28.216 1.00 89.17 A N原子73 CD PRO A 48 43.027 61.674 28.664 1.00 88.86 A C原子74 CA PRO A 48 41.116 62.476 27.383 1.00 89.64 A C原子75 CB PRO A 48 42.099 63.615 27.670 1.00 89.70 A C原子76 CG PRO A 48 43.409 62.884 27.803 1.00 89.22 A C
原子77 C PRO A 48 41.032 62.168 25.865 1.00 89.93 A C原子78 O PRO A 48 42.047 62.218 25.159 1.00 90.23 A O原子79 N ASP A 49 39.817 61.911 25.368 1.00 89.62 A N原子80 CA ASP A 49 39.571 61.579 23.950 1.00 89.54 A C原子81 CB ASP A 49 38.188 62.082 23.495 1.00 88.53 A C原子82 CG ASP A 49 37.049 61.192 23.957 1.00 86.66 A C原子83 OD1 ASP A 49 37.316 60.127 24.552 1.00 86.34 A O原子84 OD2 ASP A 49 35.881 61.561 23.716 1.00 84.70 A O原子85 C ASP A 49 40.618 62.088 22.958 1.00 89.67 A C原子86 O ASP A 49 40.411 63.109 22.302 1.00 90.28 A O原子87 N ARG A 50 41.693 61.327 22.783 1.00 89.65 A N原子88 CA ARG A 50 42.761 61.724 21.867 1.00 89.99 A C原子89 CB ARG A 50 43.890 62.413 22.645 1.00 93.04 A C原子90 CG ARG A 50 44.407 63.702 21.999 1.00 98.81 A C原子91 CD ARG A 50 45.314 63.438 20.789 1.00 103.62 A C原子92 NE ARG A 50 45.605 64.658 20.031 1.00 107.53 A N原子93 CZ ARG A 50 45.282 64.845 18.750 1.00 109.68 A C原子94 NH1 ARG A 50 44.657 63.894 18.060 1.00 110.84 A N原子95 NH2 ARG A 50 45.556 66.001 18.163 1.00 110.65 A N原子96 C ARG A 50 43.308 60.521 21.097 1.00 87.41 A C原子97 O ARG A 50 44.296 59.905 21.500 1.00 85.65 A O原子98 N PRO A 51 42.658 60.177 19.974 1.00 85.57 A N原子99 CD PRO A 51 41.431 60.869 19.548 1.00 84.89 A C原子100 CA PRO A 51 42.975 59.071 19.060 1.00 84.99 A C原子101 CB PRO A 51 41.997 59.312 17.913 1.00 85.36 A C原子102 CG PRO A 51 40.799 59.854 18.631 1.00 85.38 A C原子103 C PRO A 51 44.434 59.010 18.569 1.00 84.41 A C原子104 O PRO A 51 44.867 59.870 17.792 1.00 84.99 A O
原子105 N GLN A 52 45.148 57.945 18.958 1.00 83.27 A N原子106 CA GLN A 52 46.566 57.753 18.603 1.00 82.53 A C原子107 CB GLN A 52 47.435 57.781 19.864 1.00 84.07 A C原子108 CG GLN A 52 47.229 56.603 20.789 1.00 86.46 A C原子109 CD GLN A 52 47.519 56.949 22.247 1.00 88.48 A C原子110 OE1 GLN A 52 48.464 56.425 22.849 1.00 89.88 A O原子111 NE2 GLN A 52 46.694 57.825 22.827 1.00 88.28 A N原子112 C GLN A 52 46.924 56.501 17.803 1.00 80.58 A C原子113 O GLN A 52 46.188 55.525 17.782 1.00 80.54 A O原子114 N GLU A 53 48.095 56.538 17.176 1.00 79.33 A N原子115 CA GLU A 53 48.587 55.433 16.364 1.00 78.55 A C原子116 CB GLU A 53 49.458 55.962 15.205 1.00 80.14 A C原子117 CG GLU A 53 50.483 57.036 15.611 1.00 83.84 A C原子118 CD GLU A 53 51.551 57.317 14.539 1.00 85.69 A C原子119 OE1 GLU A 53 52.102 58.446 14.531 1.00 85.65 A O原子120 OE2 GLU A 53 51.858 56.406 13.731 1.00 86.49 A O原子121 C GLU A 53 49.351 54.389 17.186 1.00 76.89 A C原子122 O GLU A 53 50.568 54.478 17.354 1.00 75.34 A O原子123 N VAL A 54 48.615 53.406 17.703 1.00 76.02 A N原子124 CA VAL A 54 49.192 52.319 18.494 1.00 73.93 A C原子125 CB VAL A 54 48.286 51.922 19.667 1.00 73.59 A C原子126 CG1 VAL A 54 48.242 53.046 20.689 1.00 74.90 A C原子127 CG2 VAL A 54 46.894 51.582 19.161 1.00 72.04 A C原子128 C VAL A 54 49.413 51.089 17.627 1.00 72.92 A C原子129 O VAL A 54 48.489 50.606 16.963 1.00 72.97 A O原子130 N SER A 55 50.646 50.587 17.654 1.00 71.85 A N原子131 CA SERA 55 51.057 49.417 16.875 1.00 70.15 A C原子132 CB SERA 55 52.245 49.770 15.959 1.00 71.94 A C
原子133 OG SER A 55 51.966 50.872 15.101 1.00 73.30 A O原子134 C SER A 55 51.444 48.245 17.786 1.00 67.67 A C原子135 O SER A 55 52.337 48.361 18.634 1.00 66.29 A O原子136 N TYR A 56 50.778 47.112 17.575 1.00 65.56 A N原子137 CA TYR A 56 51.013 45.904 18.355 1.00 63.50 A C原子138 CB TYR A 56 49.740 45.525 19.113 1.00 62.76 A C原子139 CG TYR A 56 48.515 45.253 18.250 1.00 63.19 A C原子140 CD1 TYR A 56 47.449 46.151 18.211 1.00 62.39 A C原子141 CE1 TYR A 56 46.267 45.854 17.503 1.00 63.83 A C原子142 CD2 TYR A 56 48.382 44.051 17.548 1.00 63.71 A C原子143 CE2 TYR A 56 47.209 43.745 16.838 1.00 65.04 A C原子144 CZ TYR A 56 46.150 44.646 16.820 1.00 64.23 A C原子145 OH TYR A 56 44.979 44.316 16.148 1.00 63.09 A O原子146 C TYR A 56 51.513 44.735 17.499 1.00 62.16 A C原子147 O TYR A 56 51.437 44.769 16.276 1.00 62.63 A O原子148 N THR A 57 52.048 43.708 18.144 1.00 60.34 A N原子149 CA THR A 57 52.564 42.554 17.419 1.00 59.63 A C原子150 CB THR A 57 54.026 42.829 16.928 1.00 57.54 A C原子151 OG1 THR A 57 54.448 41.808 16.015 1.00 54.97 A O原子152 CG2 THR A 57 54.995 42.901 18.105 1.00 56.04 A C原子153 C THR A 57 52.467 41.298 18.312 1.00 60.85 A C原子154 O THR A 57 51.829 41.334 19.368 1.00 61.73 A O原子155 N ASP A 58 53.055 40.183 17.880 1.00 61.67 A N原子156 CA ASP A 58 53.003 38.937 18.655 1.00 60.38 A C原子157 CB ASP A 58 53.855 39.050 19.915 1.00 61.29 A C原子158 CL JASP A 58 55.311 39.313 19.604 1.00 60.65 A C原子159 OD1 ASP A 58 55.918 38.504 18.869 1.00 59.43 A O原子160 OD2 ASP A 58 55.841 40.333 20.097 1.00 62.10 A O
原子161 C ASP A 58 51.570 38.627 19.037 1.00 59.00 A C原子162 O ASP A 58 51.215 38.634 20.218 1.00 59.66 A O原子163 N THRA 59 50.763 38.362 18.013 1.00 57.34 A N原子164 CA THR A 59 49.346 38.063 18.153 1.00 54.67 A C原子165 CB THR A 59 48.551 38.626 16.943 1.00 55.34 A C原子166 OG1 THR A 59 48.116 39.960 17.231 1.00 55.66 A O原子167 CG2 THR A 59 47.357 37.760 16.614 1.00 55.50 A C原子168 C THR A 59 49.042 36.580 18.298 1.00 52.46 A C原子169 O THR A 59 49.484 35.756 17.497 1.00 52.93 A O原子170 N LYS A 60 48.309 36.248 19.353 1.00 50.20 A N原子171 CA LYS A 60 47.900 34.880 19.598 1.00 48.19 A C原子172 CB LYS A 60 48.973 34.095 20.370 1.00 48.28 A C原子173 CG LYS A 60 49.209 34.524 21.815 1.00 52.03 A C原子174 CD LYS A 60 50.218 33.576 22.519 1.00 35.27 A C原子175 CE LYS A 60 50.339 33.828 24.037 1.00 55.03 A C原子176 NZ LYS A 60 51.305 32.887 24.711 1.00 56.36 A N原子177 C LYS A 60 46.580 34.929 20.357 1.00 46.35 A C原子178 O LYS A 60 46.276 35.915 21.026 1.00 45.31 A O原子179 N VAL A 61 45.751 33.911 20.149 1.00 44.84 A N原子180 CA VALA 61 44.463 33.811 20.820 1.00 42.01 A C原子181 CB VALA 61 43.514 32.868 20.027 1.00 41.45 A C原子182 CG1 VAL A 61 42.091 32.955 20.561 1.00 42.35 A C原子183 CG2 VAL A 61 43.547 33.210 18.557 1.00 40.20 A C原子184 C VAL A 61 44.715 33.251 22.229 1.00 40.40 A C原子185 O VAL A 61 45.370 32.218 22.386 1.00 37.34 A O原子186 N ILE A 62 44.274 33.971 23.256 1.00 40.99 A N原子187 CA ILE A 62 44.475 33.488 24.614 1.00 43.02 A C原子188 CB ILE A 62 45.227 34.492 25.536 1.00 40.23 A C
原子189 CG2 ILE A 62 46.631 34.733 25.024 1.00 40.71 A C原子190 CG1 ILE A 62 44.445 35.787 25.711 1.00 38.13 A C原子191 CD1 ILE A 62 45.190 36.849 26.504 1.00 36.04 A C原子192 C ILE A 62 43.191 33.091 25.301 1.00 46.67 A C原子193 O ILE A 62 43.228 32.418 26.331 1.00 48.93 A O原子194 N GLY A 63 42.056 33.474 24.724 1.00 49.61 A N原子195 CA GLY A 63 40.785 33.151 25.349 1.00 53.04 A C原子196 C GLY A 63 39.552 33.066 24.462 1.00 55.86 A C原子197 O GLY A 63 39.626 33.023 23.227 1.00 56.41 A O原子198 N ASN A 64 38.403 32.994 25.126 1.00 57.93 A N原子199 CA ASNA 64 37.108 32.889 24.465 1.00 60.54 A C原子200 CB ASNA 64 37.099 31.688 23.509 1.00 59.42 A C原子201 CG ASNA 64 36.157 31.875 22.347 1.00 58.37 A C原子202 OU1 ASAN A 64 35.362 32.814 22.313 1.00 57.86 A O原子203 ND2 ASN A 64 36.251 30.985 21.373 1.00 59.04 A N原子204 C ASN A 64 36.054 32.699 25.561 1.00 62.61 AC原子205 O ASN A 64 36.387 32.424 26.723 1.00 63.00 A O原子206 N GLY A 65 34.789 32.879 25.201 1.00 64.05 A N原子207 CA GLY A 65 33.727 32.714 26.175 1.00 64.83 A C原子208 C GLY A 65 32.388 33.242 25.698 1.00 65.71 A C原子209 O GLY A 65 32.155 33.393 24.491 1.00 63.50 A O原子210 N SER A 66 31.506 33.500 26.664 1.00 67.34 A N原子211 CA SER A 66 30.161 34.025 26.415 1.00 68.47 A C原子212 CB SER A 66 29.757 34.984 27.562 1.00 71.11 A C原子213 OG SER A 66 30.761 35.958 27.857 1.00 72.83 A O原子214 C SER A 66 30.071 34.713 25.043 1.00 67.30 A C原子215 O SER A 66 29.298 34.309 24.171 1.00 67.14 A O原子216 N PHE A 67 30.858 35.771 24.885 1.00 66.38 A N
原子217 CA PHEA 67 30.953 36.527 23.638 1.00 63.66 A C原子218 CB PHEA 67 29.934 37.675 23.558 1.00 63.82 A C原子219 CG PHEA 67 29.067 37.817 24.775 1.00 64.38 A C原子220 CD1 PHE A 67 27.735 37.407 24.745 1.00 64.61 A C原子221 CD2 PHE A 67 29.584 38.345 25.955 1.00 64.60 A C原子222 CE1 PHE A 67 26.928 37.523 25.870 1.00 65.17 A C原子223 CE2 PHE A 67 28.789 38.466 27.088 1.00 66.15 A C原子224 CZ PHE A 67 27.454 38.050 27.047 1.00 64.78 A C原子225 C PHE A 67 32.371 37.086 23.610 1.00 62.03 A C原子226 O PHE A 67 33.018 37.237 24.665 1.00 63.08 A O原子227 N GLY A 68 32.887 37.285 22.403 1.00 59.06 A N原子228 CA GLY A 68 34.224 37.825 22.249 1.00 54.57 A C原子229 C GLY A 68 35.429 36.936 22.524 1.00 50.88 A C原子230 O GLY A 68 35.589 36.381 23.620 1.00 50.54 A O原子231 N VAL A 69 36.245 36.758 21.486 1.00 46.18 A N原子232 CA VALA 69 37.480 36.001 21.591 1.00 41.79 A C原子233 CB VAL A 69 37.929 35.416 20.230 1.00 39.57 A C原子234 CG1 VAL A 69 37.536 36.328 19.118 1.00 40.48 A C原子235 CG2 VAL A 69 39.423 35.223 20.219 1.00 37.24 A C原子236 C VAL A 69 38.491 37.023 22.107 1.00 39.35 A C原子237 O VAL A 69 38.333 38.217 21.894 1.00 41.42 A O原子238 N VAL A 70 39.504 36.566 22.822 1.00 37.57 A N原子239 CA VAL A 70 40.496 37.464 23.390 1.00 34.90 A C原子240 CB VAL A 70 40.453 37.400 24.928 1.00 32.97 A C原子241 CG1 VAL A 70 41.390 38.415 25.514 1.00 31.00 A C原子242 CG2 VAL A 70 39.027 37.610 25.423 1.00 29.51 A C原子243 C VAL A 70 41.881 37.082 22.878 1.00 36.21 A C原子244 O VAL A 70 42.205 35.905 22.750 1.00 35.35 A O
原子245 N TYR A 71 42.680 38.080 22.534 1.00 37.09 A N原子246 CA TYR A 71 44.006 37.817 22.018 1.00 38.38 A C原子247 CB TYR A 71 44.167 38.434 20.632 1.00 39.29 A C原子248 CG TYR A 71 43.178 37.971 19.600 1.00 40.04 A C原子249 CD1 TYR A 71 43.529 37.005 18.669 1.00 40.03 A C原子250 CE1 TYR A 71 42.648 36.620 17.676 1.00 43.33 A C原子251 CD2 TYR A 71 41.912 38.542 19.519 1.00 40.56 A C原子252 CE2 TYR A 71 41.017 38.169 18.535 1.00 41.56 A C原子253 CZ TYR A 71 41.384 37.204 17.608 1.00 45.04 A C原子254 OH TYR A 71 40.494 36.818 16.612 1.00 46.56 A O原子255 C TYR A 71 45.056 38.423 22.917 1.00 38.85 A C原子256 O TYR A 71 44.751 39.218 23.797 1.00 37.35 A O原子257 N GLN A 72 46.298 38.005 22.716 1.00 41.61 A N原子258 CA GLN A 72 47.404 38.567 23.476 1.00 45.29 A C原子259 CB GLN A 72 48.297 37.481 24.072 1.00 45.63 A C原子260 CG GLN A 72 49.349 38.062 24.978 1.00 47.29 A C原子261 CD GLN A 72 50.519 37.143 25.165 1.00 50.13 A C原子262 OE1 GLN A 72 50.915 36.844 26.294 1.00 53.20 A O原子263 NE2 GLN A 72 51.099 36.698 24.058 1.00 51.52 A N原子264 C GLN A 72 48.209 39.399 22.475 1.00 46.18 A C原子265 O GLN A 72 48.392 38.987 21.322 1.00 46.65 A O原子266 N ALA A 73 48.686 40.563 22.904 1.00 46.77 A N原子267 CA ALA A 73 49.451 41.419 22.001 1.00 45.68 A C原子268 CB ALA A 73 48.501 42.334 21.200 1.00 44.21 A C原子269 C ALA A 73 50.544 42.246 22.667 1.00 44.64 A C原子270 O ALA A 73 50.344 42.873 23.719 1.00 44.26 A O原子271 N LYS A 74 51.713 42.211 22.042 1.00 42.69 A N原子272 CA LYS A 74 52.856 42.970 22.503 1.00 43.50 A C
原子273 CB LYS A 74 54.161 42.221 22.149 1.00 42.65 A C原子274 CG LYS A 74 55.470 42.919 22.605 1.00 45.76 A C原子275 CD LYS A 74 56.709 42.000 22.490 1.00 45.94 A C原子276 CE LYS A 74 58.037 42.739 22.731 1.00 45.49 A C原子277 NZ LYS A 74 58.362 43.716 21.649 1.00 42.82 A N原子278 C LYS A 74 52.791 44.355 21.829 1.00 44.66 A C原子279 O LYS A 74 52.877 44.463 20.603 1.00 44.66 A O原子280 N LEU A 75 52.484 45.391 22.608 1.00 45.67 A N原子281 CA LEU A 75 52.446 46.745 22.069 1.00 45.49 A C原子282 CB LEU A 75 52.062 47.758 23.146 1.00 44.22 A C原子283 CG LEU A 75 50.722 47.698 23.867 1.00 42.65 A C原子284 CD1 LEU A 75 50.577 48.906 24.764 1.00 42.75 A C原子285 CD2 LEU A 75 49.626 47.699 22.860 1.00 45.10 A C原子286 C LEU A 75 53.881 47.023 21.618 1.00 47.69 A C原子287 O LEU A 75 54.837 46.602 22.278 1.00 47.15 A O原子288 N CYS A 76 54.040 47.735 20.505 1.00 49.43 A N原子289 CA CYS A 76 55.371 48.022 19.987 1.00 50.01 A C原子290 CB CYS A 76 55.291 48.362 18.501 1.00 50.31 A C原子291 SG CYSA 76 54.816 46.959 17.466 1.00 49.00 A S原子292 C CYS A 76 56.116 49.113 20.753 1.00 50.60 A C原子293 O CYS A 76 57.321 48.992 21.003 1.00 50.79 A O原子294 N ASP A 77 55.403 50.164 21.144 1.00 50.83 A N原子295 CA ASP A 77 56.035 51.256 21.882 1.00 52.89 A C原子296 CB ASP A 77 55.085 52.448 21.998 1.00 54.92 A C原子297 CG ASP A 77 55.500 53.613 21.099 1.00 56.94 A C原子298 OD1 ASP A 77 54.620 54.136 20.369 1.00 58.09 A O原子299 OD2 ASP A 77 56.701 53.994 21.124 1.00 56.18 A O原子300 C ASP A 77 56.543 50.852 23.263 1.00 52.60 A C
原子301 O ASP A 77 57.755 50.701 23.469 1.00 51.51 A O原子302 N SER A 78 55.604 50.659 24.194 1.00 53.59 A N原子303 CA SER A 78 55.907 50.267 25.578 1.00 52.82 A C原子304 CB SER A 78 54.659 50.421 26.460 1.00 51.56 A C原子305 OG SER A 78 53.572 49.657 25.971 1.00 50.80 A O原子306 C SER A 78 56.548 48.878 25.784 1.00 52.05 A C原子307 O SER A 78 57.326 48.696 26.726 1.00 54.38 A O原子308 N GLY A 79 56.247 47.921 24.902 1.00 51.13 A N原子309 CA GLY A 79 56.808 46.575 25.008 1.00 49.18 A C原子310 C GLY A 79 55.941 45.680 25.880 1.00 48.85 A C原子311 O GLY A 79 56.233 44.496 26.109 1.00 47.80 A O原子312 N GLU A 80 54.858 46.284 26.361 1.00 47.52 A N原子313 CA GLU A 80 53.880 45.649 27.226 1.00 45.90 A C原子314 CB GLU A 80 52.988 46.724 27.865 1.00 46.60 A C原子315 CG GLU A 80 53.651 47.618 28.904 1.00 49.65 A C原子316 CD GLU A 80 52.732 48.760 29.352 1.00 52.98 A C原子317 OE1 GLU A 80 52.078 49.368 28.468 1.00 56.66 A O原子318 OE2 GLU A 80 52.660 49.058 30.572 1.00 53.37 A O原子319 C GLU A 80 52.965 44.677 26.496 1.00 44.23 A C原子320 O GLU A 80 52.466 44.972 25.420 1.00 45.57 A O原子321 N LEU A 81 52.752 43.504 27.069 1.00 42.25 A N原子322 CA LEU A 81 51.810 42.588 26.460 1.00 40.35 A C原子323 CB LEU A 81 51.934 41.180 27.037 1.00 40.73 A C原子324 CG LEU A 81 53.247 40.421 26.953 1.00 41.22 A C原子325 CD1 LEU A 81 54.411 41.271 27.470 1.00 43.81 A C原子326 CD2 LEU A 81 53.094 39.157 27.780 1.00 41.64 A C原子327 C LEU A 81 50.481 43.177 26.929 1.00 38.72 A C原子328 O LEU A 81 50.419 43.845 27.970 1.00 38.10 A O
原子329 N VAL A 82 49.428 42.933 26.158 1.00 38.70 A N原子330 CA VAL A 82 48.077 43.406 26.475 1.00 36.80 A C原子331 CB VAL A 82 47.751 44.757 25.793 1.00 37.25 A C原子332 CG1 VAL A 82 48.460 45.894 26.488 1.00 36.40 A C原子333 CG2 VAL A 82 48.144 44.697 24.308 1.00 35.48 A C原子334 C VAL A 82 47.109 42.386 25.904 1.00 34.77 A C原子335 O VAL A 82 47.482 41.606 25.038 1.00 36.41 A O原子336 N ALA A 83 45.874 42.395 26.393 1.00 33.95 A N原子337 CA ALA A 83 44.840 41.486 25.906 1.00 34.92 A C原子338 CB ALA A 83 44.134 40.816 27.058 1.00 32.65 A C原子339 C ALA A 83 43.846 42.307 25.092 1.00 35.73 A C原子340 O ALA A 83 43.449 43.389 25.506 1.00 36.73 A O原子341 N ILE A 84 43.517 41.829 23.897 1.00 37.22 A N原子342 CA ILE A 84 42.562 42.507 23.025 1.00 37.12 A C原子343 CB ILE A 84 43.184 42.757 21.632 1.00 38.05 A C原子344 CG2 ILE A 84 42.123 43.281 20.656 1.00 38.96 A C原子345 CG1 ILE A 84 44.369 43.715 21.773 1.00 37.32 A C原子346 CD1 ILE A 84 45.111 43.974 20.496 1.00 38.63 A C原子347 C ILE A 84 41.281 41.670 22.894 1.00 36.12 A C原子348 O ILE A 84 41.281 40.614 22.250 1.00 36.23 A O原子349 N LYS A 85 40.204 42.142 23.526 1.00 37.57 A N原子350 CA LYS A 85 38.910 41.460 23.509 1.00 38.77 A C原子351 CB LYS A 85 38.201 41.619 24.857 1.00 36.36 A C原子352 CG LYS A 85 37.027 40.685 24.999 1.00 37.09 A C原子353 CD LYS A 85 36.080 41.081 26.130 1.00 37.90 A C原子354 CE LYS A 85 34.814 40.214 26.079 1.00 39.15 A C原子355 NZ LYS A 85 33.746 40.539 27.072 1.00 40.17 A N原子356 C LYS A 85 38.003 41.946 22.368 1.00 41.60 A C
原子357 O LYS A 85 37.274 42.945 22.508 1.00 41.50 A O原子358 N LYS A 86 38.064 41.222 21.249 1.00 42.66 A N原子359 CA LYS A 86 37.282 41.514 20.048 1.00 46.44 A C原子360 CB LYS A 86 38.046 41.014 18.819 1.00 44.97 A C原子361 CG LYS A 86 37.554 41.514 17.465 1.00 43.06 A C原子362 CD LYS A 86 38.397 40.881 16.364 1.00 39.98 A C原子363 CE LYS A 86 38.332 41.635 15.047 1.00 40.29 A C原子364 NZ LYS A 86 39.138 40.926 13.996 1.00 38.08 A N原子365 C LYS A 86 35.888 40.870 20.090 1.00 48.90 A C原子366 O LYS A 86 35.738 39.686 19.794 1.00 47.95 A O原子367 N VAL A 87 34.873 41.674 20.418 1.00 53.67 A N原子368 CA VAL A 87 33.481 41.210 20.519 1.00 56.92 A C原子369 CB VAL A 87 32.922 41.417 21.979 1.00 57.46 A C原子370 CG1 VAL A 87 33.301 42.811 22.537 1.00 58.89 A C原子371 CG2 VAL A 87 31.418 41.200 22.011 1.00 57.01 A C原子372 C VAL A 87 32.520 41.790 19.461 1.00 58.81 A C原子373 O VAL A 87 31.768 42.720 19.725 1.00 58.46 A O原子374 N LEU A 88 32.560 41.202 18.268 1.00 62.36 A N原子375 CA LEU A 88 31.738 41.586 17.115 1.00 66.69 A C原子376 CB LEU A 88 31.654 40.391 16.143 1.00 66.45 A C原子377 CG LEU A 88 30.610 40.283 15.010 1.00 65.72 A C原子378 CD1 LEU A 88 29.232 39.883 15.532 1.00 64.69 A C原子379 CD2 LEU A 88 30.520 41.581 14.235 1.00 66.21 A C原子380 C LEU A 88 30.325 42.122 17.396 1.00 70.04 A C原子381 O LEU A 88 29.951 43.202 16.919 1.00 69.57 A O原子382 N GLN A 89 29.540 41.322 18.117 1.00 74.14 A N原子383 CA GLN A 89 28.145 41.612 18.486 1.00 78.26 A C原子384 CB GLN A 89 27.981 41.624 20.014 1.00 80.37 A C
原子385 CG GLN A 89 28.592 40.416 20.720 1.00 84.39 A C原子386 CD GLN A 89 28.167 39.084 20.115 1.00 86.80 A C原子387 OE1 GLN A 89 27.061 38.955 19.580 1.00 88.73 A O原子388 NE2 GLN A 89 29.051 38.085 20.193 1.00 87.39 A N原子389 C GLN A 89 27.408 42.818 17.876 1.00 79.47 A C原子390 O GLN A 89 26.964 43.719 18.607 1.00 79.93 A O原子391 N ASP A 90 27.260 42.829 16.548 1.00 80.34 A N原子392 CA ASP A 90 26.521 43.901 15.875 1.00 80.46 A C原子393 CB ASP A 90 26.918 44.043 14.393 1.00 77.64 A C原子394 CG ASP A 90 28.337 44.609 14.188 1.00 76.14 A C原子395 OD1 ASP A 90 28.678 44.928 13.020 1.00 72.76 A O原子396 OD2 ASP A 90 29.113 44.720 15.171 1.00 73.73 A O原子397 C ASP A 90 25.061 43.460 15.982 1.00 81.90 A C原子398 O ASP A 90 24.257 43.680 15.073 1.00 82.46 A O原子399 N LYS A 91 24.773 42.735 17.066 1.00 83.55 A N原子400 CA LYS A 91 23.43542.230 17.368 1.00 84.72 A C原子401 CB LYS A 91 23.503 40.879 18.086 1.00 85.25 A C原子402 CG LYS A 91 22.135 40.280 18.370 1.00 85.50 A C原子403 CD LYS A 91 22.192 39.109 19.358 1.00 87.22 A C原子404 CE LYS A 91 22.881 37.856 18.796 1.00 87.91 A C原子405 NZ LYS A 91 24.342 37.800 19.073 1.00 87.56 A N原子406 C LYS A 91 22.762 43.237 18.280 1.00 84.57 A C原子407 O LYS A 91 23.237 43.500 19.388 1.00 82.89 A O原子408 N ARG A 92 21.656 43.800 17.813 1.00 85.67 A N原子409 CA ARG A 92 20.965 44.788 18.607 1.00 86.46 A C原子410 CB ARG A 92 20.255 45.818 17.732 1.00 87.35 A C原子411 CG ARG A 92 21.282 46.786 17.134 1.00 87.74 A C原子412 CD ARG A 92 22.292 47.185 18.237 1.00 87.41 A C
原子413 NE ARG A 92 23.515 47.818 17.741 1.00 86.69 A N原子414 CZ ARG A 92 23.815 49.109 17.885 1.00 86.44 A C原子415 NH1 ARG A 92 22.979 49.927 18.508 1.00 85.91 A N原子416 NH2 ARG A 92 24.972 49.584 17.434 1.00 87.03 A N原子417 C ARG A 92 20.135 44.269 19.760 1.00 86.49 A C原子418 O ARG A 92 18.965 43.884 19.632 1.00 85.79 A O原子419 N PHE A 93 20.869 44.174 20.866 1.00 86.66 A N原子420 CA PHE A 93 20.427 43.741 22.182 1.00 85.60 A C原子421 CB PHE A 93 21.058 42.388 22.520 1.00 87.23 A C原子422 CG PHE A 93 20.083 41.256 22.574 1.00 88.81 A C原子423 CD1 PHE A 93 19.395 40.978 23.752 1.00 89.73 A C原子424 CD2 PHE A 93 19.870 40.450 21.458 1.00 89.70 A C原子425 CE1 PHE A 93 18.505 39.908 23.823 1.00 90.90 A C原子426 CE2 PHE A 93 18.985 39.376 21.514 1.00 90.88 A C原子427 CZ PHE A 93 18.298 39.104 22.704 1.00 91.21 A C原子428 C PHE A 93 21.068 44.814 23.064 1.00 83.88 A C原子429 O PHE A 93 21.148 45.983 22.671 1.00 84.09 A O原子430 N LYS A 94 21.591 44.414 24.216 1.00 80.64 A N原子431 CA LYS A 94 22.238 45.372 25.092 1.00 77.91 A C原子432 CB LYS A 94 21.358 45.641 26.315 1.00 75.52 A C原子433 CG LYS A 94 19.923 46.039 25.981 1.00 71.68 A C原子434 CD LYS A 94 19.822 47.363 25.214 1.00 69.76 A C原子435 CE LYS A 94 20.000 48.592 26.112 1.00 69.19 A C原子436 NZ LYS A 94 19.587 49.853 25.417 1.00 66.98 A N原子437 C LYS A 94 23.622 44.873 25.515 1.00 77.27 A C原子438 O LYS A 94 23.736 43.942 26.309 1.00 77.15 A O原子439 N ASN A 95 24.671 45.444 24.927 1.00 76.47 A N原子440 CA ASN A 95 26.033 45.062 25.292 1.00 75.53 A C
原子441 CB ASN A 95 27.030 45.413 24.194 1.00 77.06 A C原子442 CG ASN A 95 28.461 45.144 24.620 1.00 78.69 A C原子443 OD1 ASN A 95 28.787 44.029 25.048 1.00 78.05 A O原子444 ND2 ASN A 95 29.314 46.171 24.551 1.00 78.69 A N原子445 C ASN A 95 26.433 45.806 26.563 1.00 73.89 A C原子446 O ASN A 95 26.598 45.204 27.625 1.00 75.23 A O原子447 N ARG A 96 26.621 47.118 26.434 1.00 70.94 A N原子448 CA ARG A 96 26.988 47.967 27.565 1.00 67.78 A C原子449 CB ARG A 96 26.060 47.697 28.756 1.00 67.41 A C原子450 CG ARG A 96 24.592 47.925 28.472 1.00 67.84 A C原子451 CD ARG A 96 23.743 47.571 29.688 1.00 68.02 A C原子452 NE ARG A 96 22.334 47.904 29.473 1.00 69.43 A N原子453 CZ ARG A 96 21.318 47.071 29.685 1.00 69.75 A C原子454 NH1 ARG A 96 21.546 45.840 30.125 1.00 68.74 A N原子455 NH2 ARG A 96 20.072 47.469 29.446 1.00 70.71 A N原子456 C ARG A 96 28.430 47.790 28.030 1.00 65.38 A C原子457 O ARG A 96 28.931 48.586 28.824 1.00 64.64 A O原子458 N GLU A 97 29.115 46.765 27.544 1.00 62.10 A N原子459 CA GLU A 97 30.463 46.568 28.033 1.00 58.33 A C原子460 CB GLU A 97 31.103 45.310 27.464 1.00 54.66 A C原子461 CG GLU A 97 32.313 44.919 28.252 1.00 51.20 A C原子462 CD GLU A 97 33.045 43.731 27.687 1.00 51.15 A C原子463 OE1 GLU A 97 33.697 43.042 28.489 1.00 50.55 A O原子464 OE2 GLU A 97 32.996 43.493 26.460 1.00 50.87 A O原子465 C GLU A 97 31.346 47.769 27.774 1.00 58.86 A C原子466 O GLU A 97 32.033 48.240 28.676 1.00 59.91 A O原子467 N LEU A 98 31.306 48.284 26.550 1.00 58.36 A N原子468 CA LEU A 98 32.133 49.426 26.170 1.00 56.36 A C
原子469 CB LEU A 98 31.915 49.760 24.691 1.00 58.43 A C原子470 CG LEU A 98 32.615 50.940 23.991 1.00 59.61 A C原子471 CD1 LEU A 98 31.924 52.275 24.316 1.00 59.81 A C原子472 CD2 LEU A 98 34.097 50.969 24.324 1.00 59.74 A C原子473 C LEU A 98 31.923 50.662 27.028 1.00 55.35 A C原子474 O LEU A 98 32.892 51.292 27.439 1.00 54.06 A O原子475 N GLN A 99 30.664 51.002 27.308 1.00 55.73 A N原子476 CA GLN A 99 30.365 52.190 28.108 1.00 55.38 A C原子477 CB GLN A 99 28.969 52.750 27.770 1.00 55.93 A C原子478 CG GLN A 99 27.797 51.842 28.051 1.00 55.63 A C原子479 CD GLN A 99 26.992 52.295 29.265 1.00 58.08 A C原子480 OE1 GLN A 99 25.770 52.121 29.318 1.00 58.26 A O原子481 NE2 GLN A 99 27.674 52.882 30.245 1.00 59.21 A N原子482 C GLN A 99 30.565 52.074 29.624 1.00 54.26 A C原子483 O GLN A 99 30.742 53.086 30.299 1.00 55.13 A O原子484 N ILE A 100 30.555 50.853 30.155 1.00 53.11 A N原子485 CA ILE A 100 30.746 50.638 31.597 1.00 51.69 A C原子486 CB ILE A 100 29.982 49.376 32.116 1.00 51.11 A C原子487 CG2 ILE A 100 30.351 49.059 33.558 1.00 48.57 A C原子488 CG1 ILE A 100 28.477 49.583 32.056 1.00 51.95 A C原子489 CD1 ILE A 100 27.701 48.525 32.846 1.00 54.98 A C原子490 C ILE A 100 32.228 50.486 31.965 1.00 51.22 A C原子491 O ILE A 100 32.637 50.821 33.066 1.00 50.62 A O原子492 N MET A 101 33.038 49.976 31.053 1.00 51.32 A N原子493 CA MET A 101 34.447 49.805 31.359 1.00 53.62 A C原子494 CB MET A 101 35.075 48.730 30.460 1.00 53.39 A C原子495 CG MET A 101 34.861 47.295 30.970 1.00 50.53 A C原子496 SD MET A 101 36.349 46.274 30.786 1.00 51.20 A S
原子497 CE MET A 101 35.988 45.468 29.259 1.00 46.01 A C原子498 C MET A 101 35.261 51.110 31.358 1.00 56.00 A C原子499 MET A 101 36.223 51.248 32.118 1.00 56.87 A O原子500 N ARG A 102 34.895 52.061 30.500 1.00 58.14 A N原子501 CA ARG A 102 35.592 53.346 30.466 1.00 59.40 A C原子502 CB ARG A 102 35.658 53.908 29.039 1.00 60.86 A C原子503 CG ARG A 102 34.333 53.917 28.295 1.00 62.76 A C原子504 CD ARG A 102 34.556 54.210 26.816 1.00 63.43 A C原子505 NE ARG A 102 35.345 55.421 26.613 1.00 64.58 A N原子506 CZ ARG A 102 34.985 56.431 25.825 1.00 66.38 A C原子507 NH1 ARG A 102 33.837 56.381 25.150 1.00 66.63 A N原子508 NH2 ARG A 102 35.770 57.502 25.728 1.00 67.99 A N原子509 C ARG A 102 34.808 54.258 31.405 1.00 58.97 A C原子510 O ARG A 102 34.267 55.288 31.002 1.00 61.35 A O原子511 N LYS A 103 34.739 53.820 32.663 1.00 57.41 A N原子512 CA LYS A 103 34.029 54.487 33.759 1.00 54.91 A C原子513 CB LYS A 103 32.517 54.234 33.605 1.00 56.05 A C原子514 CG LYS A 103 31.627 54.647 34.781 1.00 58.18 A C原子515 CD LYS A 103 30.193 54.114 34.600 1.00 59.37 A C原子516 CE LYS A 103 29.227 54.645 35.665 1.00 59.73 A C原子517 NZ LYS A 103 27.813 54.217 35.410 1.00 60.49 A N，原子518 C LYS A 103 34.546 53.816 35.045 1.00 52.85 A C原子519 O LYS A 103 34.203 54.200 36.171 1.00 52.32 A O原子520 N LEU A 104 35.406 52.820 34.858 1.00 49.69 A N原子521 CA LEU A 104 35.954 52.071 35.984 1.00 47.86 A C原子522 CB LEU A 104 35.576 50.579 35.880 1.00 46.36 A C原子523 CG LEU A 104 34.101 50.161 35.883 1.00 42.83 A C原子524 CD1 LEU A 104 34.011 48.661 35.581 1.00 41.91 A C
原子525 CD2 LEU A 104 33.424 50.515 37.215 1.00 40.25 A C原子526 C LEU A 104 37.462 52.206 36.212 1.00 45.38 A C原子527 O LEU A 104 38.277 52.140 35.285 1.00 44.77 A O原子528 N ASP A 105 37.804 52.352 37.487 1.00 44.69 A N原子529 CA ASP A 105 39.181 52.492 37.939 1.00 43.77 A C原子530 CB ASP A 105 39.541 53.977 38.068 1.00 45.37 A C原子531 CG ASP A 105 41.024 54.207 38.292 1.00 46.12 A C原子532 OD1 ASP A 105 41.354 55.140 39.041 1.00 48.52 A O原子533 OD2 ASP A 105 41.859 53.476 37.720 1.00 46.94 A O原子534 C ASP A 105 39.319 51.812 39.310 1.00 41.80 A C原子535 O ASP A 105 39.042 52.437 40.347 1.00 42.18 A O原子536 N HIS A 106 39.675 50.520 39.298 1.00 37.59 A N原子537 CA HIS A 106 39.886 49.739 40.522 1.00 33.12 A C原子538 CB HIS A 106 38.625 48.963 40.939 1.00 31.57 A C原子539 CG HIS A 106 38.578 48.580 42.395 1.00 27.81 A C原子540 CD2 HIS A 106 38.058 49.224 43.470 1.00 28.07 A C原子541 ND1 HIS A 106 39.047 47.372 42.871 1.00 27.43 A N原子542 CE1 HIS A 106 38.816 47.289 44.172 1.00 27.42 A C原子543 NE2 HIS A 106 38.218 48.400 44.560 1.00 26.05 A N原子544 C HIS A 106 41.026 48.776 40.226 1.00 33.24 A C原子545 O HIS A 106 41.189 48.294 39.089 1.00 31.87 A O原子546 N CYS A 107 41.865 48.585 41.241 1.00 33.77 A N原子547 CA CYS A 107 43.020 47.701 41.159 1.00 32.36 A C原子548 CB CYS A 107 43.930 47.914 42.380 1.00 34.33 A C原子549 SG CYS A 107 43.112 47.762 44.014 1.00 37.57 A S原子550 C CYS A 107 42.571 46.244 41.074 1.00 31.13 A C原子551 O CYS A 107 43.382 45.357 40.789 1.00 33.04 A O原子552 N ASN A 108 41.285 46.004 41.339 1.00 26.92 A N
原子553 CA ASN A 108 40.739 44.665 41.279 1.00 23.95 A C原子554 CB ASN A 108 40.096 44.303 42.613 1.00 23.35 A C原子555 CG ASN A 108 41.134 44.085 43.697 1.00 22.75 A C原子556 OD1 ASN A 108 40.935 44.430 44.866 1.00 23.77 A O原子557 ND2 ASN A 108 42.267 43.504 43.306 1.00 21.50 A N原子558 C ASN A 108 39.805 44.466 40.084 1.00 24.27 A C原子559 O ASN A 108 39.003 43.533 40.043 1.00 22.46 A O原子560 N ILE A 109 39.992 45.310 39.070 1.00 23.70 A N原子561 CA ILE A 109 39.224 45.256 37.833 1.00 23.34 A C原子562 CB ILE A 109 38.015 46.273 37.873 1.00 23.41 A C原子563 CG2 ILE A 109 37.277 46.312 36.535 1.00 25.40 A C原子564 CG1 ILE A 109 37.005 45.860 38.940 1.00 23.61 A C原子565 CD1 ILE A 109 35.928 46.851 39.186 1.00 23.75 A C原子566 C ILE A 109 40.203 45.559 36.678 1.00 23.85 A C原子567 O ILE A 109 40.974 46.510 36.763 1.00 24.61 A O原子568 N VAL A 110 40.222 44.718 35.638 1.00 25.42 A N原子569 CA VAL A 110 41.134 44.929 34.500 1.00 30.37 A C原子570 CB VAL A 110 40.903 43.942 33.297 1.00 31.05 A C原子571 CG1 VAL A 110 42.224 43.339 32.825 1.00 29.62 A C原子572 CG2 VAL A 110 39.891 42.883 33.637 1.00 34.59 A C原子573 C VAL A 110 40.928 46.332 33.945 1.00 32.52 A C原子574 O VAL A 110 39.797 46.809 33.834 1.00 31.60 A O原子575 N ARG A 111 42.030 46.991 33.607 1.00 36.56 A N原子576 CA ARG A 111 41.964 48.339 33.058 1.00 38.83 A C原子577 CB ARG A 111 43.181 49.179 33.466 1.00 39.00 A C原子578 CG ARG A 111 43.134 50.595 32.904 1.00 39.84 A C原子579 CD ARG A 111 44.454 51.313 33.058 1.00 41.02 A C原子580 NE ARG A 111 45.522 50.590 32.389 1.00 43.02 A N
原子581 CZ ARG A 111 46.817 50.835 32.542 1.00 45.60 A C原子582 NH1 ARG A 111 47.234 51.803 33.355 1.00 45.36 A N原子583 NH2 ARG A 111 47.695 50.107 31.864 1.00 47.87 A N原子584 C ARG A 111 41.873 48.328 31.545 1.00 38.29 A C原子585 A RGU A 111 42.586 47.578 30.864 1.00 37.13 A O原子586 N LEU A 112 40.946 49.138 31.043 1.00 40.88 A N原子587 CA LEU A 112 40.741 49.304 29.618 1.00 42.64 A C原子588 CB LEU A 112 39.266 49.584 29.317 1.00 42.13 A C原子589 CG LEU A 112 38.941 50.028 27.885 1.00 41.67 A C原子590 CD1 LEU A 112 39.294 48.951 26.863 1.00 39.98 A C原子591 CD2 LEU A 112 37.472 50.402 27.811 1.00 42.47 A C原子592 C LEU A 112 41.605 50.483 29.174 1.00 44.33 A C原子593 O LEU A 112 41.341 51.643 29.515 1.00 44.94 A O原子594 N ARG A 113 42.683 50.170 28.474 1.00 46.58 A N原子595 CA ARG A 113 43.562 51.201 27.977 1.00 49.96 A C原子596 CB ARG A 113 44.880 50.596 27.536 1.00 49.33 A C原子597 CG ARG A 113 45.533 49.731 28.574 1.00 52.35 A C原子598 CD ARG A 113 46.918 49.337 28.119 1.00 54.97 A C原子599 NE ARG A 113 47.440 48.197 28.856 1.00 56.47 A N原子600 CZ ARG A 113 48.623 48.180 29.449 1.00 57.97 A C原子601 NH1 ARG A 113 49.397 49.259 29.390 1.00 57.41 A N原子602 NH2 ARG A 113 49.040 47.072 30.063 1.00 60.91 A N原子603 C ARG A 113 42.895 51.899 26.790 1.00 53.46 A C原子604 O ARG A 113 42.491 53.059 26.903 1.00 55.67 A O原子605 N TYR A 114 42.724 51.164 25.684 1.00 55.99 A N原子606 CA TYR A 114 42.129 51.693 24.447 1.00 58.32 A C原子607 CB TYR A 114 43.200 51.786 23.347 1.00 57.35 A C原子608 CG TYR A 114 44.544 52.332 23.792 1.00 57.73 A C
原子609 CD1 TYR A 114 45.668 51.518 23.809 1.00 57.85 A C原子610 CE1 TYR A 114 46.894 52.003 24.214 1.00 60.01 A C原子611 CD2 TYR A 114 44.688 53.656 24.195 1.00 59.32 A C原子612 CE2 TYR A 114 45.910 54.154 24.604 1.00 59.56 A C原子613 CZ TYR A 114 47.013 53.325 24.610 1.00 60.94 A C原子614 OH TYR A 114 48.248 53.819 24.996 1.00 64.22 A O原子615 C TYR A 114 40.984 50.824 23.933 1.00 60.21 A C原子616 O TYR A 114 40.771 49.734 24.437 1.00 60.68 A O原子617 N PHE A 115 40.282 51.304 22.905 1.00 64.05 A N原子618 CA PHE A 115 39.155 50.583 22.279 1.00 68.07 A C原子619 CB PHE A 115 37.855 50.790 23.077 1.00 69.09 A C原子620 CG PHE A 115 37.194 52.124 22.831 1.00 70.84 A C原子621 CD1 PHE A 115 36.181 52.250 21.882 1.00 71.34 A C原子622 CD2 PHE A 115 37.597 53.254 23.537 1.00 71.16 A C原子623 CE1 PHE A 115 35.586 53.479 21.639 1.00 71.98 A C原子624 CE2 PHE A 115 37.006 54.489 23.300 1.00 71.38 A C原子625 CZ PHE A 115 36.000 54.604 22.351 1.00 71.48 A C原子626 C PHE A 115 38.918 51.055 20.832 1.00 70.42 A C原子627 O PHE A 115 38.644 52.237 20.607 1.00 71.61 A O原子628 N PHE A 116 39.018 50.145 19.859 1.00 72.32 A N原子629 CA PHE A 116 38.791 50.508 18.450 1.00 73.84 A C原子630 CB PHE A 116 40.107 50.552 17.668 1.00 74.62 A C原子631 CG PHE A 116 40.862 49.247 17.642 1.00 76.56 A C原子632 CD1 PHE A 116 40.730 48.374 16.563 1.00 77.09 A C原子633 CD2 PHE A 116 41.768 48.930 18.655 1.00 76.69 A C原子634 CE1 PHE A 116 41.491 47.212 16.489 1.00 77.07 A C原子635 CE2 PHE A 116 42.535 47.772 18.592 1.00 75.51 A C原子636 CZ PHE A 116 42.399 46.912 17.507 1.00 76.47 A C
原子637 C PHE A 116 37.756 49.649 17.709 1.00 74.55 A C原子638 O PHE A 116 36.990 48.915 18.339 1.00 75.46 A O原子639 N TYR A 117 37.671 49.836 16.388 1.00 74.71 A N原子640 CA TYR A 117 36.741 49.093 15.514 1.00 74.55 A C原子641 CB TYR A 117 35.539 49.968 15.112 1.00 67.13 A C原子642 CG TYR A 117 34.583 50.334 16.234 1.00 59.10 A C原子643 CD1 TYR A 117 33.429 49.606 16.451 1.00 55.00 A C原子644 CE1 TYR A 117 32.533 49.962 17.445 1.00 54.09 A C原子645 CD2 TYR A 117 34.821 51.432 17.046 1.00 57.38 A C原子646 CE2 TYR A 117 33.931 51.799 18.049 1.00 54.84 A C原子647 CZ TYR A 117 32.785 51.060 18.250 1.00 53.40 A C原子648 OH TYR A 117 31.908 51.397 19.271 1.00 48.17 A O原子649 C TYR A 117 37.514 48.640 14.263 1.00 78.31 A C原子650 O TYR A 117 38.433 49.337 13.817 1.00 78.31 A O原子651 N SER A 118 37.173 47.478 13.704 1.00 82.98 A N原子652 CA SER A 118 37.898 47.000 12.521 1.00 88.44 A C原子653 CB SER A 118 39.377 46.765 12.871 1.00 87.26 A C原子654 OG SER A 118 39.555 45.560 13.607 1.00 85.26 A O原子655 C SER A 118 37.347 45.726 11.877 1.00 92.60 A C原子656 O SER A 118 36.213 45.326 12.129 1.00 93.26 A O原子657 N SER A 119 38.182 45.114 11.035 1.00 97.53 A N原子658 CA SER A 119 37.896 43.862 10.322 1.00 102.53 A C原子659 CB SER A 119 37.729 42.696 11.306 1.00 102.11 A C原子660 OG SER A 119 38.932 42.454 12.013 1.00 103.47 A O原子661 C SER A 119 36.770 43.846 9.284 1.00 105.96 A C原子662 O SER A 119 36.047 44.838 9.107 1.00 106.64 A O原子663 N GLY A 120 36.638 42.697 8.612 1.00 109.33 A N原子664 CA GLY A 120 35.637 42.511 7.565 1.00 113.28 A C
原子665 C GLY A 120 36.097 43.092 6.229 1.00 115.71 A C原子666 O GLY A 120 35.968 44.303 6.012 1.00 116.49 A O原子667 N GLU A 121 36.587 42.241 5.317 1.00 117.12 A N原子668 CA GLU A 121 37.094 42.706 4.011 1.00 118.33 A C原子669 CB GLU A 121 38.562 42.255 3.818 1.00 119.45 A C原子670 CG GLU A 121 39.588 43.009 4.709 1.00 120.23 A C原子671 CD GLU A 121 40.994 42.385 4.724 1.00 120.94 A C原子672 OE1 GLU A 121 41.656 42.355 3.660 1.00 121.17 A O原子673 OE2 GLU A 121 41.443 41.948 5.812 1.00 120.33 A O原子674 C GLU A 121 36.268 42.473 2.711 1.00 118.24 A C原子675 O GLU A 121 36.817 42.058 1.681 1.00 118.10 A O原子676 N LYS A 122 34.964 42.779 2.769 1.00 117.74 A N原子677 CA LYS A 122 34.025 42.681 1.626 1.00 116.06 A C原子678 CB LYS A 122 33.818 41.240 1.145 1.00 114.80 A C原子679 CG LYS A 122 32.895 41.127-0.084 1.00 112.84 A C原子680 CD LYS A 122 33.557 41.699-1.360 1.00 111.74 A C原子681 CE LYS A 122 33.412 43.225-1.538 1.00 110.22 A C原子682 NZ LYS A 122 32.064 43.663-1.976 1.00 109.02 A N原子683 C LYS A 122 32.655 43.315 1.927 1.00 115.39 A C原子684 O LYS A 122 32.201 44.207 1.200 1.00 115.16 A O原子685 N LYS A 123 31.984 42.825 2.972 1.00 114.01 A N原子686 CA LYS A 123 30.684 43.364 3.370 1.00 112.21 A C原子687 CB LYS A 123 29.582 42.295 3.279 1.00 112.84 A C原子688 CG LYS A 123 29.035 42.074 1.864 1.00 113.44 A C原子689 CD LYS A 123 27.628 41.481 1.897 1.00 113.87 A C原子690 CE LYS A 123 26.938 41.543 0.529 1.00 114.47 A C原子691 NZ LYS A 123 27.535 40.621-0.478 1.00 114.00 A N原子692 C LYS A 123 30.685 44.036 4.755 1.00 110.67 A C
原子693 O LYS A 123 31.713 44.533 5.222 1.00 110.40 A O原子694 N ASP A 124 29.522 44.049 5.400 1.00 109.19 A N原子695 CA ASP A 124 29.345 44.685 6.711 1.00 106.97 A C原子696 CB ASP A 124 27.846 44.737 7.069 1.00 106.42 A C原子697 CG ASP A 124 27.142 43.400 6.871 1.00 105.35 A C原子698 OD1 ASP A 124 27.356 42.462 7.677 1.00 104.12 A O原子699 OD2 ASP A 124 26.361 43.297 5.902 1.00 105.49 A O原子700 C ASP A 124 30.156 44.190 7.929 1.00 105.28 A C原子701 O ASP A 124 31.391 44.071 7.871 1.00 104.96 A O原子702 N GLU A 125 29.427 43.973 9.035 1.00 102.47 A N原子703 CA GLU A 125 29.943 43.528 10.340 1.00 97.57 A C原子704 CB GLU A 125 29.870 41.995 10.483 1.00 96.91 A C原子705 CG GLU A 125 30.510 41.197 9.350 1.00 97.60 A C原子706 CD GLU A 125 30.624 39.710 9.666 1.00 97.50 A C原子707 OE1 GLU A 125 29.748 39.190 10.389 1.00 97.21 A O原子708 OE2 GLU A 125 31.595 39.067 9.199 1.00 97.16 A O原子709 C GLU A 125 31.322 44.081 10.757 1.00 94.98 A C原子710 O GLU A 125 32.366 43.542 10.373 1.00 93.99 A O原子711 N VAL A 126 31.300 45.198 11.496 1.00 91.91 A N原子712 CA VAL A 126 32.510 45.863 12.018 1.00 8.16 A C原子713 CB VAL A 126 32.541 47.415 11.711 1.00 88.34 A C原子714 CG1 VAL A 126 32.865 47.667 10.234 1.00 88.24 A C原子715 CG2 VAL A 126 31.215 48.082 12.075 1.00 88.10 A C原子716 C VAL A 126 32.599 45.614 13.537 1.00 85.14 A C原子717 O VAL A 126 31.857 46.204 14.325 1.00 85.94 A O原子718 N TYR A 127 33.505 44.721 13.929 1.00 81.03 A N原子719 CA TYR A 127 33.685 44.320 15.327 1.00 76.14 A C原子720 CB TYR A 127 34.626 43.095 15.406 1.00 77.59 A C
原子721 CG TYR A 127 34.600 42.131 14.214 1.00 79.50 A C原子722 CD1 TYR A 127 34.716 42.592 12.900 1.00 80.76 A C原子723 CE1 TYR A 127 34.739 41.701 11.807 1.00 82.49 A C原子724 CD2 TYR A 127 34.506 40.753 14.410 1.00 80.31 A C原子725 CE2 TYR A 127 34.530 39.854 13.329 1.00 82.30 A C原子726 CZ TYR A 127 34.647 40.333 12.022 1.00 82.76 A C原子727 OH TYR A 127 34.671 39.465 10.931 1.00 83.20 A O原子728 C TYR A 127 34.211 45.418 16.264 1.00 71.69 A C原子729 O TYR A 127 34.801 46.408 15.817 1.00 70.97 A O原子730 N LEU A 128 33.957 45.241 17.560 1.00 66.32 A N原子731 CA LEU A 128 34.445 46.158 18.600 1.00 61.86 A C原子732 CB LEU A 128 33.369 46.421 19.670 1.00 60.15 A C原子733 CG LEU A 128 33.840 46.909 21.058 1.00 58.82 A C原子734 CD1 LEU A 128 34.623 48.192 20.938 1.00 58.66 A C原子735 CD2 LEU A 128 32.655 47.088 22.026 1.00 58.42 A C原子736 C LEU A 128 35.659 45.505 19.276 1.00 58.96 A C原子737 O LEU A 128 35.648 44.310 19.552 1.00 59.74 A O原子738 N ASN A 129 36.714 46.271 19.520 1.00 54.46 A N原子739 CA ASN A 129 37.882 45.717 20.184 1.00 51.02 A C原子740 CB ASN A 129 39.118 45.808 19.295 1.00 52.71 A C原子741 CG ASN A 129 38.895 45.221 17.934 1.00 53.98 A C原子742 OD1 ASN A 129 37.965 45.612 17.246 1.00 56.47 A O原子743 ND2 ASN A 129 39.757 44.290 17.523 1.00 54.27 A N原子744 C ASN A 129 38.162 46.463 21.475 1.00 48.35 A C原子745 O ASN A 129 37.960 47.666 21.572 1.00 47.89 A O原子746 N LEU A 130 38.610 45.735 22.483 1.00 45.63 A N原子747 CA LEU A 130 38.952 46.347 23.754 1.00 42.61 A C原子748 CB LEU A 130 38.062 45.800 24.863 1.00 41.40 A C
原子749 CG LEU A 130 36.568 46.041 24.688 1.00 42.53 A C原子750 CD1 LEU A 130 35.778 45.528 25.907 1.00 41.18 A C原子751 CD2 LEU A 130 36.351 47.519 24.504 1.00 43.02 A C原子752 C LEU A 130 40.396 45.988 24.041 1.00 41.25 A C原子753 O LEU A 130 40.766 44.833 23.884 1.00 43.06 A O原子754 N VAL A 131 41.244 46.975 24.321 1.00 40.44 A N原子755 CA VAL A 131 42.641 46.686 24.662 1.00 40.17 A C原子756 CB VAL A 131 43.628 47.665 24.007 1.00 40.61 A C原子757 CG1 VAL A 131 45.061 47.270 24.367 1.00 38.55 A C原子758 CG2 VAL A 131 43.436 47.685 22.502 1.00 37.67 A C原子759 C VAL A 131 42.758 46.783 26.198 1.00 41.44 A C原子760 O VAL A 131 42.668 47.873 26.772 1.00 42.39 A O原子761 N LEU A 132 42.957 45.635 26.853 1.00 40.54 A N原子762 CA LEU A 132 43.024 45.552 28.316 1.00 38.63 A C原子763 CB LEU A 132 42.024 44.496 28.785 1.00 36.48 A C原子764 CG LEU A 132 40.590 44.617 28.268 1.00 32.94 A C原子765 CD1 LEU A 132 39.871 43.287 28.435 1.00 34.26 A C原子766 CD2 LEU A 132 39.864 45.734 28.979 1.00 31.75 A C原子767 C LEU A 132 44.396 45.180 28.851 1.00 37.78 A C原子768 O LEU A 132 45.309 44.884 28.086 1.00 38.30 A O原子769 N ASP A 133 44.541 45.231 30.175 1.00 37.79 A N原子770 CA ASP A 133 45.792 44.848 30.829 1.00 36.20 A C原子771 CB ASP A 133 45.711 45.104 32.333 1.00 39.92 A C原子772 CG ASP A 133 45.820 46.564 32.695 1.00 42.64 A C原子773 OD1 ASP A 133 46.491 47.319 31.952 1.00 40.59 A O原子774 OD2 ASP A 133 45.253 46.933 33.755 1.00 46.04 A O原子775 C ASP A 133 45.910 43.343 30.643 1.00 35.09 A C原子776 O ASP A 133 44.899 42.632 30.749 1.00 36.43 A O
原子777 N TYR A 134 47.111 42.837 30.374 1.00 30.51 A N原子778 CA TYR A 134 47.229 41.401 30.212 1.00 31.24 A C原子779 CB TYR A 134 48.452 40.995 29.408 1.00 30.01 A C原子780 CG TYR A 134 48.587 39.495 29.329 1.00 30.92 A C原子781 CDI TYR A 134 47.674 38.742 28.607 1.00 31.11 A C原子782 CE1 TYR A 134 47.760 37.346 28.559 1.00 31.93 A C原子783 CD2 TYR A 134 49.601 38.821 30.009 1.00 30.38 A C原子784 CE2 TYR A 134 49.700 37.420 29.971 1.00 29.91 A C原子785 CZ TYR A 134 48.772 36.684 29.244 1.00 31.78 A C原子786 OH TYR A 134 48.822 35.292 29.205 1.00 33.71 A O原子787 C TYR A 134 47.341 40.762 31.568 1.00 30.92 A C原子788 O TYR A 134 48.216 41.144 32.327 1.00 31.99 A O原子789 N VAL A 135 46.422 39.834 31.869 1.00 31.34 A N原子790 CA VAL A 135 46.398 39.059 33.124 1.00 30.12 A C原子791 CB VAL A 135 45.112 39.323 33.925 1.00 30.41 A C原子792 CG1 VAL A 135 45.351 39.049 35.420 1.00 28.09 A C原子793 CG2 VAL A 135 44.669 40.751 33.721 1.00 31.27 A C原子794 C VAL A 135 46.492 37.574 32.693 1.00 30.65 A C原子795 O VAL A 135 45.562 37.027 32.082 1.00 31.35 A O原子796 N PRO A 136 47.600 36.897 33.069 1.00 28.98 A N原子797 CD PRO A 136 48.526 37.489 34.052 1.00 27.15 A C原子798 CA PRO A 136 47.975 35.504 32.784 1.00 29.38 A C原子799 CB PRO A 136 49.385 35.410 33.369 1.00 28.43 A C原子800 CG PRO A 136 49.336 36.301 34.517 1.00 27.21 A C原子801 C PRO A 136 47.095 34.285 33.154 1.00 30.94 A C原子802 O PRO A 136 47.037 33.303 32.384 1.00 32.42 A O原子803 N GLU A 137 46.396 34.352 34.290 1.00 28.86 A N原子804 CA GLU A 137 45.546 33.246 34.733 1.00 26.99 A C
原子805 CB GLU A 137 46.230 32.476 35.884 1.00 24.62 A C原子806 CG GLU A 137 47.481 31.679 35.488 1.00 25.11 A C原子807 CD GLU A 137 47.174 30.425 34.642 1.00 28.61 A C原子808 OE1 GLU A 137 45.979 30.104 34.459 1.00 27.71 A O原子809 OE2 GLU A 137 48.131 29.754 34.161 1.00 32.05 A O原子810 C GLU A 137 44.140 33.691 35.146 1.00 23.84 A C原子811 O GLU A 137 43.799 34.858 35.041 1.00 26.68 A O原子812 N THR A 138 43.302 32.724 35.506 1.00 23.98 A N原子813 CA THR A 138 41.938 32.957 35.978 1.00 23.44 A C原子814 CB THR A 138 40.875 32.629 34.896 1.00 24.38 A C原子815 OG1 THR A 138 40.950 31.252 34.516 1.00 23.40 A O原子816 CG2 THR A 138 41.099 33.462 33.675 1.00 26.18 A C原子817 C THR A 138 41.718 32.021 37.178 1.00 25.19 A C原子818 O THR A 138 42.396 31.008 37.315 1.00 25.00 A O原子819 N VAL A 139 40.833 32.402 38.090 1.00 26.96 A N原子820 CA VAL A 139 40.518 31.561 39.246 1.00 24.71 A C原子821 CB VAL A 139 39.422 32.245 40.146 1.00 21.67 A C原子822 CG1 VAL A 139 38.919 31.305 41.214 1.00 20.54 A C原子823 CG2 VAL A 139 40.030 33.498 40.829 1.00 19.99 A C原子824 C VAL A 139 40.098 30.183 38.684 1.00 25.77 A C原子825 O VAL A 139 40.489 29.144 39.190 1.00 26.29 A O原子826 N TYR A 140 39.427 30.175 37.543 1.00 27.74 A N原子827 CA TYR A 140 39.028 28.909 36.957 1.00 28.83 A C原子828 CB TYR A 140 38.306 29.128 35.631 1.00 31.23 A C原子829 CG TYR A 140 37.899 27.823 35.031 1.00 31.38 A C原子830 CD1 TYR A 140 36.954 27.024 35.663 1.00 32.48 A C原子831 CE1 TYR A 140 36.668 25.776 35.204 1.00 35.51 A C原子832 CD2 TYR A 140 38.537 27.331 33.914 1.00 31.73 A C
原子833 CE2 TYR A 140 38.261 26.086 33.443 1.00 34.86 A C原子834 CZ TYR A 140 37.328 25.299 34.095 1.00 37.26 A C原子835 OH TYR A 140 37.093 24.006 33.669 1.00 43.07 A O原子836 C TYR A 140 40.228 27.973 36.706 1.00 28.58 A C原子837 O TYR A 140 40.276 26.861 37.220 1.00 27.27 A O原子838 N ARG A 141 41.175 28.425 35.884 1.00 29.70 A N原子839 CA ARG A 141 42.367 27.648 35.540 1.00 27.80 A C原子840 CB ARG A 141 43.222 28.402 34.526 1.00 29.79 A C原子841 CG ARG A 141 42.673 28.338 33.116 1.00 30.98 A C原子842 CD ARG A 141 43.345 29.337 32.236 1.00 33.78 A C原子843 NE ARG A 141 44.790 29.177 32.242 1.00 37.91 A N原子844 CZ ARG A 141 45.495 28.771 31.191 1.00 42.94 A C原子845 NH1 ARG A 141 44.881 28.476 30.052 1.00 45.84 A N原子846 NH2 ARG A 141 46.817 28.702 31.256 1.00 46.11 A N原子847 C ARG A 141 43.205 27.235 36.739 1.00 27.98 A C原子848 O ARG A 141 43.615 26.073 36.822 1.00 27.80 A O原子849 N VAL A 142 43.455 28.176 37.658 1.00 27.34 A N原子850 CA VAL A 142 44.233 27.900 38.883 1.00 28.31 A C原子851 CB VAL A 142 44.595 29.205 39.698 1.00 26.72 A C原子852 CG1 VAL A 142 45.162 28.827 41.055 1.00 26.02 A C原子853 CG2 VAL A 142 45.638 30.038 38.951 1.00 22.80 A C原子854 C VAL A 142 43.493 26.897 39.788 1.00 27.97 A C原子855 O VAL A 142 44.088 25.962 40.302 1.00 29.73 A O原子856 N ALA A 143 42.184 27.065 39.919 1.00 28.69 A N原子857 CA ALA A 143 41.370 26.174 40.731 1.00 27.52 A C原子858 CB ALA A 143 39.959 26.713 40.859 1.00 27.01 A C原子859 C ALA A 143 41.357 24.772 40.134 1.00 29.06 A C原子860 O ALA A 143 41.314 23.795 40.884 1.00 28.56 A O
原子861 N ARG A 144 41.396 24.689 38.798 1.00 27.51 A N原子862 CA ARG A 144 41.408 23.417 38.057 1.00 29.74 A C原子863 CB ARG A 144 40.978 23.653 36.604 1.00 33.05 A C原子864 CG ARG A 144 41.024 22.468 35.654 1.00 35.25 A C原子865 CD ARG A 144 41.357 22.999 34.238 1.00 40.10 A C原子866 NE ARG A 144 40.302 22.802 33.234 1.00 44.51 A N原子867 CZ ARG A 144 40.257 23.422 32.046 1.00 46.13 A C原子868 NHL ARG A 144 41.208 24.299 31.706 1.00 44.86 A N原子869 NH2 ARG A 144 39.297 23.121 31.168 1.00 45.68 A N原子870 C ARG A 144 42.802 22.731 38.126 1.00 29.30 A C原子871 O ARG A 144 42.895 21.501 38.091 1.00 29.07 A O原子872 N HIS A 145 43.871 23.522 38.236 1.00 27.70 A N原子873 CA HIS A 145 45.218 22.971 38.376 1.00 28.20 A C原子874 CB HIS A 145 46.261 24.098 38.418 1.00 32.67 A C原子875 CG HIS A 145 47.614 23.658 38.894 1.00 37.97 A C原子876 CD2 HIS A 145 48.718 23.254 38.209 1.00 38.19 A C原子877 ND1 HIS A 145 47.938 23.543 40.231 1.00 41.76 A N原子878 CE1 HIS A 145 49.172 23.082 40.354 1.00 40.83 A C原子879 NE2 HIS A 145 49.662 22.900 39.137 1.00 41.20 A N原子880 C HIS A 145 45.298 22.153 39.683 1.00 28.12 A C原子881 O HIS A 145 45.862 21.069 39.731 1.00 29.84 A O原子882 N TYR A 146 44.752 22.706 40.750 1.00 24.78 A N原子883 CA TYR A 146 44.743 22.044 42.037 1.00 25.16 A C原子884 CB TYR A 146 44.311 23.041 43.116 1.00 21.12 A C原子885 CG TYR A 146 45.452 23.906 43.527 1.00 20.16 A C原子886 CD1 TYR A 146 45.651 25.156 42.954 1.00 18.74 A C原子887 CE1 TYR A 146 46.788 25.909 43.242 1.00 20.28 A C原子888 CD2 TYR A 146 46.410 23.430 44.409 1.00 22.97 A C
原子889 CE2 TYR A 146 47.549 24.166 44.708 1.00 23.73 A C原子890 CZ TYR A 146 47.739 25.408 44.121 1.00 21.19 A C原子891 OH TYR A 146 48.889 26.129 44.408 1.00 25.87 A O原子892 C TYR A 146 43.819 20.850 41.998 1.00 27.00 A C原子893 O TYR A 146 44.177 19.779 42.449 1.00 29.00 A O原子894 N SER A 147 42.633 21.043 41.435 1.00 31.32 A N原子895 CA SER A 147 41.610 20.006 41.303 1.00 34.47 A C原子896 CB SER A 147 40.407 20.594 40.558 1.00 34.35 A C原子897 OG SER A 147 39.272 19.759 40.645 1.00 40.28 A O原子898 C SER A 147 42.134 18.754 40.561 1.00 36.70 A C原子899 O SER A 147 41.869 17.618 40.973 1.00 36.08 A O原子900 N ARG A 148 42.867 18.961 39.468 1.00 37.11 A N原子901 CA ARG A 148 43.406 17.844 38.712 1.00 39.33 A C原子902 CB ARG A 148 43.914 18.314 37.350 1.00 41.05 A C原子903 CG ARG A 148 42.824 18.454 36.295 1.00 44.82 A C原子904 CD ARG A 148 43.416 18.854 34.952 1.00 47.26 A C原子905 NE ARG A 148 42.377 19.097 33.957 1.00 51.12 A N原子906 CZ ARG A 148 42.412 20.078 33.055 1.00 53.10 A C原子907 NH1 ARG A 148 43.444 20.918 33.019 1.00 53.33 A N原子908 NH2 ARG A 148 41.408 20.223 32.194 1.00 52.55 A N原子909 C ARG A 148 44.519 17.103 39.458 1.00 40.50 A C原子910 O ARG A 148 44.702 15.891 39.275 1.00 39.30 A O原子911 N ALA A 149 45.276 17.844 40.269 1.00 41.08 A N原子912 CA ALA A 149 46.379 17.280 41.046 1.00 39.72 A C原子913 CB ALA A 149 47.435 18.338 41.303 1.00 38.73 A C原子914 C ALA A 149 45.877 16.707 42.363 1.00 40.87 A C原子915 O ALA A 149 46.656 16.519 43.305 1.00 42.44 A O原子916 N LYS A 150 44.564 16.468 42.417 1.00 41.69 A N
原子917 CA LYS A 150 43.867 15.919 43.582 1.00 41.88 A C原子918 CB LYS A 150 44.342 14.493 43.857 1.00 33 A C原子919 CG LYS A 150 44.012 13.514 42.721 1.00 45.60 A C原子920 CD LYS A 150 42.543 13.661 42.270 1.00 49.16 A C原子921 CE LYS A 150 41.523 13.401 43.398 1.00 48.64 A C原子922 NZ LYS A 150 40.187 14.027 43.117 1.00 47.59 A N原子923 C LYS A 150 43.874 16.752 44.866 1.00 42.31 A C原子924 O LYS A 150 43.549 16.244 45.940 1.00 42.11 A O原子925 N GLN A 151 44.201 18.038 44.740 1.00 41.75 A N原子926 CA GLN A 151 44.244 18.959 45.876 1.00 40.32 A C原子927 CB GLN A 151 45.615 19.625 45.985 1.00 41.69 A C原子928 CG GLN A 151 46.766 18.676 45.761 1.00 45.57 A C原子929 CD GLN A 151 48.064 19.397 45.444 1.00 47.43 A C原子930 OE1 GLN A 151 48.818 18.989 44.551 1.00 48.65 A O原子931 NE2 GLN A 151 48.333 20.475 46.178 1.00 47.43 A N原子932 C GLN A 151 43.177 20.048 45.756 1.00 38.97 A C原子933 O GLN A 151 42.486 20.193 44.737 1.00 37.05 A O原子934 N THR A 152 43.078 20.833 46.817 1.00 36.12 A N原子935 CA THR A 152 42.120 21.911 46.887 1.00 30.43 A C原子936 CB THR A 152 41.160 21.627 48.098 1.00 32.05 A C原子937 OG1 THR A 152 40.084 22.567 48.118 1.00 34.33 A O原子938 CG2 THR A 152 41.930 21.596 49.441 1.00 25.51 A C原子939 C THR A 152 42.998 23.173 47.031 1.00 29.40 A C原子940 O THR A 152 44.150 23.082 47.451 1.00 29.65 A O原子941 N LEU A 153 42.522 24.313 46.545 1.00 26.53 A N原子942 CA LEU A 153 43.283 25.552 46.649 1.00 24.95 A C原子943 CB LEU A 153 42.507 26.688 45.954 1.00 26.82 A C原子944 CG LEU A 153 43.120 28.061 45.618 1.00 25.65 A C
原子945 CD1 LEU A 153 44.236 27.921 44.557 1.00 25.60 A C原子946 CD2 LEU A 153 42.017 29.006 45.115 1.00 24.41 A C原子947 C LEU A 153 43.510 25.890 48.130 1.00 24.38 A C原子948 O LEU A 153 42.570 25.885 48.921 1.00 23.56 A O原子949 N PRO A 154 44.774 26.158 48.527 1.00 26.09 A N原子950 CD PRO A 154 46.020 26.126 47.731 1.00 24.06 A C原子951 CA PRO A 154 45.063 26.493 49.929 1.00 24.19 A C原子952 CB PRO A 154 46.526 26.914 49.894 1.00 24.86 A C原子953 CG PRO A 154 47.081 26.048 48.822 1.00 25.37 A C原子954 C PRO A 154 44.176 27.629 50.385 1.00 27.34 A C原子955 O PRO A 154 43.904 28.554 49.615 1.00 30.70 A O原子956 N VAL A 155 43.729 27.551 51.636 1.00 26.02 A N原子957 CA VAL A 155 42.847 28.544 52.200 1.00 26.41 A C原子958 CB VAL A 155 42.546 28.252 53.648 1.00 26.31 A C原子959 CG1 VAL A 155 41.260 28.980 54.060 1.00 27.04 A C原子960 CG2 VAL A 155 42.423 26.771 53.829 1.00 28.43 A C原子961 C VAL A 155 43.344 29.969 52.065 1.00 26.71 A C原子962 O VAL A 155 42.533 30.879 51.874 1.00 29.38 A O原子963 N ILE A 156 44.660 30.170 52.136 1.00 25.06 A N原子964 CA ILE A 156 45.215 31.515 52.001 1.00 23.58 A C原子965 CB ILE A 156 46.733 31.532 52.236 1.00 22.58 A C原子966 CG2 ILE A 156 47.440 30.804 51.121 1.00 22.74 A C原子967 CG1 ILE A 156 47.222 32.971 52.397 1.00 23.47 A C原子968 CD1 ILE A 156 46.427 33.793 53.445 1.00 24.69 A C原子969 C ILE A 156 44.856 32.150 50.642 1.00 22.60 A C原子970 O ILE A 156 44.598 33.344 50.569 1.00 21.23 A O原子971 N TYR A 157 44.779 31.341 49.587 1.00 21.96 A N原子972 CA TYR A 157 44.421 31.854 48.266 1.00 21.89 A C
原子973 CB TYRA 157 44.919 30.929 47.142 1.00 24.47 A C原子974 CG TYRA 157 46.425 30.911 46.981 1.00 29.69 A C原子975 CD1 TYR A 157 47.139 29.723 47.061 1.00 31.71 A C原子976 CE1 TYR A 157 48.527 29.704 46.968 1.00 32.61 A C原子977 CD2 TYR A 157 47.137 32.088 46.792 1.00 30.79 A C原子978 CE2 TYR A 157 48.525 32.085 46.697 1.00 33.89 A C原子979 CZ TYR A 157 49.221 30.887 46.790 1.00 34.85 A C原子980 OH TYR A 157 50.608 30.887 46.750 1.00 36.72 A O原子981 C TYR A 157 42.914 32.043 48.174 1.00 21.57 A C原子982 O TYR A 157 42.426 32.935 47.481 1.00 20.67 A O原子983 N VAL A 158 42.166 31.182 48.849 1.00 22.66 A N原子984 CA VAL A 158 40.708 31.313 48.826 1.00 21.35 A C原子985 CB VAL A 158 39.970 30.100 49.543 1.00 17.78 A C原子986 CG1 VAL A 158 38.514 30.422 49.774 1.00 14.58 A C原子987 CG2 VAL A 158 40.067 28.818 48.712 1.00 14.89 A C原子988 C VAL A 158 40.375 32.648 49.495 1.00 22.61 A C原子989 O VAL A 158 39.525 33.393 49.009 1.00 27.34 A O原子990 N LYS A 159 41.057 32.961 50.599 1.00 20.08 A N原子991 CA LYS A 159 40.823 34.228 51.291 1.00 18.19 A C原子992 CB LYS A 159 41.669 34.295 52.575 1.00 18.97 A C原子993 CG LYS A 159 41.241 33.346 53.655 1.00 17.13 A C原子994 CD LYS A 159 42.174 33.347 54.851 1.00 17.71 A C原子995 CE LYS A 159 41.796 32.245 55.871 1.00 15.78 A C原子996 NZ LYS A 159 42.733 32.136 57.037 1.00 17.90 A N原子997 C LYS A 159 41.186 35.395 50.351 1.00 18.53 A C原子998 O LYS A 159 40.364 36.256 50.041 1.00 19.01 A O原子999 N LEU A 160 42.413 35.367 49.852 1.00 20.41 A N原子1000 CA LEU A 160 42.911 36.392 48.953 1.00 22.14 A C
原子1001 CB LEU A 160 44.369 36.101 48.590 1.00 24.48 A C原子1002 CG LEU A 160 45.432 36.386 49.659 1.00 25.34 A C原子1003 CD1 LEU A 160 46.664 35.516 49.430 1.00 27.51 A C原子1004 CD2 LEU A 160 45.773 37.893 49.668 1.00 26.79 A C原子1005 C LEU A 160 42.093 36.623 47.684 1.00 21.83 A C原子1006 O LEU A 160 41.830 37.768 47.338 1.00 24.16 A O原子1007 N TYR A 161 41.703 35.555 46.978 1.00 21.65 A N原子1008 CA TYR A 161 40.911 35.689 45.740 1.00 18.41 A C原子1009 CB TYR A 161 40.875 34.353 44.965 1.00 20.20 A C原子1010 CG TYR A 161 42.259 33.836 44.550 1.00 24.61 A C原子1011 CD1 TYR A 161 43.403 34.613 44.726 1.00 23.78 A C原子1012 CE1 TYR A 161 44.665 34.159 44.321 1.00 26.70 A C原子1013 CD2 TYR A 161 42.416 32.572 43.952 1.00 25.92 A C原子1014 CE2 TYR A 161 43.671 32.109 43.541 1.00 27.86 A C原子1015 CZ TYR A 161 44.801 32.910 43.727 1.00 29.25 A C原子1016 OH TYR A 161 46.070 32.470 43.314 1.00 34.56 A O原子1017 C TYRA 161 39.499 36.171 46.061 1.00 16.19 A C原子1018 O TYRA 161 38.999 37.121 45.477 1.00 11.97 A O原子1019 N META 162 38.883 35.552 47.055 1.00 16.43 A N原子1020 CA MET A 162 37.543 35.938 47.444 1.00 19.11 A C原子1021 CB MET A 162 36.992 34.972 48.506 1.00 20.40 A C原子1022 CG MET A 162 36.446 33.660 47.954 1.00 21.64 A C原子1023 SD MET A 162 35.135 33.905 46.727 1.00 25.37 A S原子1024 CE MET A 162 36.064 33.640 45.329 1.00 23.88 A C原子1025 C MET A 162 37.484 37.363 47.973 1.00 22.02 A C原子1026 O MET A 162 36.556 38.108 47.666 1.00 24.37 A O原子1027 N TYR A 163 38.455 37.737 48.801 1.00 23.77 A N原子1028 CA TYR A 163 38.479 39.088 49.367 1.00 22.41 A C
原子1029 CB TYR A 163 39.664 39.242 50.306 1.00 22.27 A C原子1030 CG TYR A 163 39.826 40.634 50.856 1.00 22.47 A C原子1031 CD1 TY R A 163 39.240 40.997 52.058 1.00 21.90 A C原子1032 CE1 TY R A 163 39.398 42.269 52.564 1.00 23.96 A C原子1033 CD2 TYR A 163 40.572 41.581 50.174 1.00 22.00 A C原子1034 CE2 TYR A 163 40.736 42.851 50.664 1.00 23.66 A C原子1035 CZ TYR A 163 40.154 43.197 51.862 1.00 23.14 A C原子1036 OH TYR A 163 40.384 44.450 52.395 1.00 27.41 A O原子1037 C TYR A 163 38.519 40.180 48.279 1.00 21.87 A C原子1038 O TYR A 163 37.752 41.138 48.319 1.00 20.75 A O原子1039 N GLN A 164 39.413 40.006 47.310 1.00 20.19 A N原子1040 CA GLN A 164 39.570 40.929 46.213 1.00 18.36 A C原子1041 CB GLN A 164 40.806 40.555 45.416 1.00 17.98 A C原子1042 CG GLN A 164 42.077 40.776 46.177 1.00 19.68 A C原子1043 CD GLN A 164 43.305 40.305 45.441 1.00 24.12 A C原子1044 OE1 GLN A 164 43.826 41.002 44.568 1.00 26.81 A O]原子1045 NE2 GLN A 164 43.797 39.131 45.805 1.00 24.95 A N原子1046 C GLN A 164 38.359 40.898 45.306 1.00 21.03 A C原子1047 O GLN A 164 38.088 41.864 44.594 1.00 22.49 A O原子1048 N LEU A 165 37.662 39.763 45.270 1.00 25.43 A N原子1049 CA LEU A 165 36.458 39.626 44.433 1.00 24.56 A C原子1050 CB LEU A 165 35.952 38.181 44.448 1.00 26.41 A C原子1051 CG LEU A 165 34.899 37.750 43.422 1.00 27.21 A C原子1052 CD1 LEU A 165 33.808 36.930 44.087 1.00 26.04 A C原子1053 CD2 LEU A 165 34.337 38.949 42.683 1.00 26.49 A C原子1054 C LEU A 165 35.397 40.545 45.018 1.00 25.10 A C原子1055 O LEU A 165 34.775 41.331 44.300 1.00 24.18 A O原子1056 N PHE A 166 35.210 40.456 46.333 1.00 25.76 A N
原子1057 CA PHE A 166 34.240 41.308 47.016 1.00 27.18 A C原子1058 CB PHE A 166 34.065 40.879 48.460 1.00 25.41 A C原子1059 CG PHE A 166 33.331 39.584 48.610 1.00 25.89 A C原子1060 CD1 PHE A 166 33.975 38.456 49.095 1.00 25.44 A C原子1061 CD2 PHE A 166 31.990 39.497 48.264 1.00 23.82 A C原子1062 CE1 PHE A 166 33.290 37.257 49.233 1.00 27.27 A C原子1063 CE2 PHE A 166 31.292 38.305 48.395 1.00 23.99 A C原子1064 CZ PHE A 166 31.939 37.180 48.881 1.00 24.37 A C原子1065 C PHE A 166 34.577 42.795 46.924 1.00 28.83 A C原子1066 O PHE A 166 33.674 43.600 46.712 1.00 32.98 A O原子1067 N ARG A 167 35.860 43.157 47.028 1.00 29.02 A N原子1068 CA ARG A 167 36.280 44.561 46.926 1.00 29.11 A C原子1069 CB ARG A 167 37.803 44.717 46.987 1.00 29.85 A C原子1070 CG A4RG A 167 38.357 45.047 48.345 1.00 33.71 A C原子1071 CD ARG A 167 39.821 45.452 48.240 1.00 35.16 A C原子1072 NE ARG A 167 40.000 46.716 47.523 1.00 36.03 A N原子1073 CZ ARG A 167 41.112 47.438 47.577 1.00 32.13 A C原子1074 NH1 ARG A 167 42.121 47.012 48.315 1.00 33.00 A N原子1075 NH2 ARG A 167 41.219 48.565 46.891 1.00 32.45 A N原子1076 C ARG A 167 35.836 45.119 45.602 1.00 27.36 A C原子1077 O ARG A 167 35.350 46.249 45.512 1.00 28.57 A O原子1078 N SER A 168 36.047 44.325 44.5764 1.00 25.95 A N原子1079 CA SER A 168 35.688 44.746 43.227 1.00 25.72 A C原子1080 CB SER A 168 36.237 43.771 42.162 1.00 24.35 A C原子1081 OG SER A 168 35.622 42.502 42.228 1.00 24.26 A O原子1082 C SER A 168 34.178 44.879 43.151 1.00 24.47 A C原子183 O SER A 168 33.682 45.802 42.532 1.00 24.30 A O原子1084 N LEU A 169 33.456 43.990 43.824 1.00 23.95 A N
原子1085 CA LEU A 169 32.000 44.049 43.801 1.00 24.98 A C原子1086 CB LEU A 169 31.359 42.796 44.415 1.00 24.67 A C原子1087 CG LEU A 169 31.312 41.496 43.604 1.00 22.03 A C原子1088 CD1 LEU A 169 30.369 40.533 44.259 1.00 21.18 A C原子1089 CD2 LEU A 169 30.866 41.789 42.177 1.00 23.84 A C原子1090 C LEU A 169 31.517 45.281 44.544 1.00 27.72 A C原子1091 O LEU A 169 30.616 45.970 44.079 1.00 29.52 A O原子1092 N ALA A 170 32.101 45.538 45.709 1.00 28.15 A N原子1093 CA ALA A 170 31.728 46.680 46.526 1.00 27.37 A C原子1094 CB ALA A 170 32.653 46.773 47.722 1.00 24.60 A C原子1095 C ALA A 170 31.836 47.945 45.701 1.00 29.32 A C原子1096 O ALA A 170 30.975 48.813 45.751 1.00 31.35 A O原子1097 N TYR A 171 32.878 48.012 44.892 1.00 31.67 A N原子1098 CA TYR A 171 33.153 49.182 44.071 1.00 34.20 A C原子1099 CB TYR A 171 34.594 49.125 43.519 1.00 35.01 A C原子1100 CG TYR A 171 34.932 50.153 42.440 1.00 36.05 A C原子1101 CD1 TYR A 171 35.165 51.491 42.757 1.00 36.55 A C原子1102 CE1 TYR A 171 35.485 52.426 41.759 1.00 34.98 A C原子1103 CD2 TYR A 171 35.032 49.775 41.102 1.00 35.50 A C原子1104 CE2 TYR A 171 35.349 50.693 40.109 1.00 35.45 A C原子1105 CZ TYR A 171 35.575 52.019 40.437 1.00 35.83 A C原子1106 OH TYR A 171 35.878 52.931 39.436 1.00 33.90 A O原子1107 C TYR A 171 32.157 49.413 42.955 1.00 34.90 A C原子1108 O TYR A 171 31.845 50.556 42.637 1.00 36.36 A O原子1109 N ILE A 172 31.685 48.350 42.316 1.00 35.15 A N原子1110 CA ILE A 172 30.728 48.535 41.241 1.00 32.43 A C原子1111 CB ILE A 172 30.716 47.354 40.208 100 32.82 A C原子1112 CG2 ILE A 172 32.008 47.363 39.367 1.00 30.44 A C
原子1113 CG1 ILE A 172 30.473 46.003 40.889 1.00 30.73 A C原子1114 CD1 ILE A 172 30.186 44.906 39.907 1.00 28.01 A C原子1115 C ILE A 172 29.355 48.756 41.850 1.00 33.06 A C原子1116 O ILE A 172 28.649 49.665 41.462 1.00 33.78 A O原子1117 N HIS A 173 28.994 47.956 42.838 1.00 33.57 A N原子1118 CA HIS A 173 27.705 48.119 43.482 1.00 38.13 A C原子1119 CB HIS A 173 27.489 47.057 44.561 1.00 38.L21 A C原子1120 CG HIS A 173 27.453 45.662 44.034 1.00 37.10 A C原子1121 CD2 HIS A 173 27.645 45.174 42.787 1.00 36.51 A C原子1122 ND1 HIS A 173 27.175 44.579 44.841 1.00 35.25 A N原子1123 CE1 HIS A 173 27.197 43.480 44.107 1.00 37.48 A C原子1124 NE2 HIS A 173 27.479 43.809 42.858 1.00 35.95 A N原子1125 C HIS A 173 27.550 49.497 44.133 1.00 42.62 A C原子1126 O HIS A 173 26.461 49.832 44.618 1.00 46.29 A O原子1127 N SER A 174 28.636 50.267 44.223 1.00 44.10 A N原子1128 CA SER A 1784 28.550 51.606 44.818 1.00 45.16 A C原子1129 CB SER A 174 29.861 52.006 45.516 1.00 42.98 A C原子1130 OG SER A 174 30.862 52.381 44.585 1.00 40.08 A O原子1131 C SER A 174 28.161 52.621 43.721 1.00 46.86 A C原子1132 O SER A 174 27.863 53.784 44.006 1.00 49.12 A O原子1133 N PHE A 175 28.185 52.162 42.469 1.00 47.61 A N原子1134 CA PHE A 175 27.799 52.958 41.302 1.00 49.07 A C原子1135 CB PHE A 175 28.778 52.766 40.152 1.00 51.72 A C原子1136 CG PHE A 175 29.980 53.625 40.233 1.00 56.04 A C原子1137 CDI PHE A 175 31.088 53.345 39.440 1.00 57.99 A C原子1138 CD2 PHE A 175 30.007 54.728 41.088 1.00 57.69 A C原子1139 CE1 PHE A 175 32.214 54.157 39.488 1.00 60.19 A C原子1140 CE2 PHE A 175-31.124 55.555 41.153 1.00 58.16 A C
原子1141 CZ PHE A 175 32.233 55.271 40.354 1.00 60.56 A C原子1142 C PHE A 175 26.452 52.421 40.838 1.00 49.69 A C原子1143 O PHE A 175 25.915 52.867 39.816 1.00 50.31 A O原子1144 N GLY A 176 25.931 51.445 41.590 1.00 49.12 A N原子1145 CA GLY A 176 24.669 50.806 41.259 1.00 46.45 A C原子1146 C GLY A 176 24.842 49.799 40.128 1.00 44.90 A C原子1147 O GLY A 176 23.853 49.326 39.566 1.00 45.37 A O原子1148 N ILE A 177 26.098 49.489 39.780 1.00 41.77 A N原子1149 CA ILE A 177 26.406 48.534 38.707 1.00 39.39 A C原子1150 CB ILE A 77 27.753 48.873 37.983 1.00 36.54 A C原子1151 CG2 ILE A 177 27.969 47.936 36.789 1.00 38.95 A C原子1152 CG1 ILE A 177 27.713 50.309 37.448 1.00 36.23 A C原子1153 CD1 ILE A 177 28.870 50.689 36.531 1.00 34.19 A C原子1154 C ILE A 177 26.387 47.055 39.153 1.00 37.59 A C原子1155 O ILE A 177 26.849 46.708 40.234 1.00 36.47 A O原子1156 N CYS A 178 25.774 46.209 38.333 1.00 36.06 A N原子1157 CA CYS A 178 25.668 44.787 38.623 1.00 35.83 A C原子1158 CB CYS A 178 24.207 44.366 38.636 1.00 36.65 A C原子1159 SG CYS A 178 23.933 42.728 39.283 1.00 41.98 A S原子1160 C CYS A 178 26.404 44.054 37.514 1.00 36.68 A C原子1161 O CYS A 178 26.168 44.312 36.318 1.00 36.59 A O原子1162 N HIS A 179 27.314 43.163 37.908 1.00 35.03 A N原子1163 CA HIS A 179 28.114 42.423 36.942 1.00 33.21 A C原子1164 CB HIS A 179 29.282 41.716 37.644 1.00 32.61 A C原子1165 CG HIS A 179 30.272 41.119 36.700 1.00 30.80 A C原子1166 CD2 HIS A 179 31.376 41.643 36.113 1.00 31.78 A C原子1167 ND1 HIS A 179 30.160 39.835 36.218 1.00 30.90 A N原子1168 CE1 HIS A 179 31.148 39.593 35.374 1.00 30.00 A C
原子1169 NE2 HIS A 179 31.900 40.675 35.296 1.00 29.07 A N原子1170 C HIS A 179 27.256 41.429 36.180 1.00 33.40 A C原子1171 O HIS A 179 27.333 41.347 34.952 1.00 32.87 A O原子1172 N ARG A 180 26.455 40.673 36.933 1.00 34.70 A N原子1173 CA ARG A 180 25.519 39.664 36.405 1.00 34.36 A C原子1174 CB ARG A 180 24.431 40.330 35.537 1.00 32.84 A C原子1175 CG ARG A 180 23.661 41.435 36.265 1.00 33.19 A C原子1176 CD ARG A 180 22.369 41.788 35.554 1.00 35.01 A C原子1177 NE ARG A 180 22.531 42.077 34.120 1.00 37.70 A N原子1178 CZ ARG A 180 21.535 42.466 33.312 1.00 36.42 A C原子1179 NH1 ARG A 180 20.308 42.633 33.793 1.00 31.94 A N原子1180 NH2 ARG A 180 21.745 42.601 32.005 1.00 34.86 A N原子1181 C ARG A 180 26.093 38.440 35.691 1.00 33.32 A C原子1182 O ARG A 180 25.373 37.759 34.970 1.00 35.45 A O原子1183 N ASP A 181 27.373 38.145 35.913 1.00 31.42 A N原子1184 CA ASP A 181 28.029 36.993 35.286 1.00 28.48 A C原子1185 CB ASP A 181 28.402 37.318 33.837 1.00 29.60 A C原子1186 CG ASP A 181 28.786 36.086 33.050 1.00 31.80 A C原子1187 OD1 ASP A 181 28.451 34.977 33.518 1.00 30.23 A O原子1188 OD2 ASP A 181 29.419 36.230 31.973 1.00 34.83 A O原子1189 C ASP A 181 29.272 36.603 36.091 1.00 27.54 A C原子1190 O ASP A 181 30.349 36.324 35.551 1.00 24.95 A O原子1191 N ILE A 182 29.118 36.639 37.404 1.00 24.85 A N原子1192 CA ILE A 182 30.206 36.299 38.289 1.00 26.96 A C原子1193 CB ILE A 182 29.945 36.849 39.728 1.00 25.13 A C原子1194 CG2 ILE A 182 30.890 36.205 40.718 1.00 23.49 A C原子1195 CG1 ILE A 182 30.038 38.392 39.737 1.00 25.25 A C原子1196 CD1 ILE A 182 31.359 38.950 39.271 1.00 26.54 A C
原子1197 C ILE A 182 30.472 34.788 38.306 1.00 26.98 A C原子1198 O ILE A 182 29.604 33.999 38.681 1.00 27.37 A O原子1199 N LYS A 183 31.657 34.411 37.825 1.00 26.70 A N原子1200 CA LYS A 183 32.112 33.021 37.768 1.00 26.63 A C原子1201 CB LYS A 183 31.493 32.265 36.568 1.00 24.83 A C原子1202 CG LYS A 183 31.887 32.781 35.199 1.00 24.93 A C原子1203 CD LYS A 183 31.170 32.010 34.116 1.00 28.93 A C原子1204 CE LYS A 183 31.310 32.670 32.752 1.00 33.05 A C原子1205 NZ LYS A 183 30.929 31.747 31.630 1.00 36.58 A N原子1206 C LYS A 183 33.647 33.027 37.692 1.00 26.01 A C原子1207 O LYS A 183 34.261 34.044 37.378 1.00 26.68 A O原子1208 N PRO A 184 34.286 31.890 38.014 1.00 25.65 A N原子1209 CD PRO A 184 33.653 30.627 38.426 1.00 25.23 A C原子1210 CA PRO A 184 35.744 31.746 37.995 1.00 22.74 A C原子1211 CB PRO A 184 35.937 30.257 38.256 1.00 23.88 A C原子1212 CG PRO A 184 34.800 29.930 39.141 1.00 23.86 A C原子1213 C PRO A 184 36.406 32.163 36.687 1.00 21.53 A C原子1214 O PRO A 184 37.461 32.764 36.698 1.00 21.96 A O原子1215 N GLN A 185 35.795 31.827 35.565 1.00 22.84 A N原子1216 CA GLN A 185 36.357 32.169 34.254 1.00 23.03 A C原子1217 CB GLN A 185 35.533 31.525 33.146 1.00 24.06 A C原子1218 CG GLN A 185 35.478 30.000 33.203 1.00 28.72 A C原子1219 CD GLN A 185 34.367 29.454 34.106 1.00 32.32 A C原子1220 OE1 GLN A 185 33.912 30.120 35.042 1.00 36.77 A O原子1221 NE2 GLN A 185 33.926 28.233 33.819 1.00 34.64 A N原子1222 C GLN A 185 36.437 33.666 34.024 1.00 22.17 A C原子1223 O GLN A 185 37.173 34.132 33.163 1.00 22.19 A O原子1224 N ASN A 186 35.629 34.417 34.760 1.00 23.70 A N
原子1225 CA ASN A 186 35.619 35.876 34.650 1.00 24.35 A C原子1226 CB ASN A 186 34.214 36.432 34.774 1.00 24.49 A C原子1227 CG ASN A 186 33.387 36.159 33.570 1.00 27.41 A C原子1228 OD1 ASN A 186 33.912 36.066 32.439 1.00 27.69 A O原子1229 ND2 ASN A 186 32.079 36.000 33.785 1.00 24.24 A N原子1230 C ASN A 186 36.464 36.573 35.699 1.00 26.47 A C原子1231 O ASN A 186 36.426 37.802 35.795 1.00 28.78 A O原子1232 N LEU A 187 37.170 35.794 36.520 1.00 25.93 A N原子1233 CA LEU A 187 38.037 36.335 37.563 1.00 24.39 A C原子1234 CB LEU A 187 37.769 35.647 38.903 1.00 21.68 A C原子1235 CG LEU A 187 36.292 35.588 39.348 1.00 21.52 A C原子1236 CD1 LEU A 187 36.179 34.855 40.652 1.00 16.97 A C原子1237 CD2 LEU A 187 35.731 36.965 39.539 1.00 18.81 A C原子1238 C LEU A 187 39.477 36.116 37.115 1.00 25.35 A C原子1239 O LEU A 187 39.991 35.005 37.147 1.00 25.06 A O原子1240 N LEU A 188 40.082 37.177 36.592 1.00 26.51 A N原子1241 CA LEU A 188 41.450 37.119 36.114 1.00 23.80 A C原子1242 CB LEU A 188 41.766 38.324 35.222 1.00 24.03 A C原子1243 CG LEU A 188 40.899 38.449 33.971 1.00 18.91 A C原子1244 CD1 LEU A 188 41.491 39.559 33.136 1.00 20.30 A C原子1245 CD2 LEU A 188 40.853 37.132 33.180 1.00 19.91 A C原子1246 C LEU A 188 42.382 37.041 37.306 1.00 24.18 A C原子1247 O LEU A 188 42.041 37.493 38.390 1.00 21.55 A O原子1248 N LEU A 189 43.604 36.589 37.070 1.00 26.20 A N原子1249 CA LEU A 189 44.519 36.393 38.157 1.00 27.92 A C原子1250 CB LEU A 189 44.140 35.039 38.740 1.00 29.84 A C原子1251 CG LEU A 189 44.250 34.680 40.198 1.00 32.69 A C原子1252 CD1 LEU A 189 43.640 33.305 40.374 1.00 33.69 A C
原子1253 CD2 LEU A 189 45.706 34.684 40.610 1.00 37.86 A C原子1254 C LEU A 189 46.004 36.379 37.756 100 28.63 A C原子1255 O LEU A 189 46.377 35.849 36.717 1.00 27.82 A O原子1256 N ASP A 190 46.836 36.987 38.597 1.00 30.40 A N原子1257 CA ASP A 190 48.285 36.992 38.420 1.00 32.67 A C原子1258 CB ASP A 190 48.843 38.419 38.519 1.00 33.70 A C原子1259 CG ASP A 190 50.371 38.482 38.373 1.00 34.20 A C原子1260 OD1 ASP A 190 50.927 39.565 38.599 1.00 36.02 A O原子1261 OD2 ASP A 190 51.021 37.472 38.045 1.00 35.65 A O原子1262 C ASP A 190 48.757 36.117 39.594 1.00 31.59 A C原子1263 O ASP A 190 48.814 36.562 40.727 1.00 33.25 A O原子1264 N PRO A 191 49.092 34.850 39.326 1.00 32.88 A N原子1265 CD PRO A 191 49.230 34.236 37.993 1.00 31.26 A C原子1266 CA PRO A 191 49.537 33.928 40.374 1.00 33.35 A C原子1267 CB PRO A 191 49.774 32.636 39.601 1.00 32.59 A C原子1268 CG PRO A 191 50.214 33.140 38.252 1.00 32.61 A C原子1269 C PRO A 191 50.736 34.317 41.250 1.00 35.09 A C原子1270 O PRO A 191 50.793 33.909 42.420 1.00 36.26 A O原子1271 N ASP A 192 51.681 35.079 40.692 1.00 35.22 A N原子1272 CA ASP A 192 52.884 35.510 41.414 1.00 37.07 A C原子1273 CB ASP A 192 53.900 36.153 40.470 1.00 40.26 A C原子1274 CG ASP A 192 54.673 35.151 39.641 1.00 40.42 A C原子1275 OD1 ASP A 192 54.441 33.930 39.776 1.00 37.69 A O原子1276 OD2 ASP A 192 55.527 35.614 38.851 1.00 41.42 A O原子1277 C ASP A 192 52.576 36.545 42.478 1.00 38.30 A C原子1278 O ASP A 192 53.160 36.515 43.566 1.00 41.04 A O原子1279 N THR A 193 51.721 37.508 42.129 1.00 37.07 A N原子1280 CA THR A 193 51.348 38.574 43.055 1.00 34.71 A C
原子1281 CB THR A 193 51.306 39.942 42.337 1.00 32.86 A C原子1282 OG1 THR A 193 50.274 39.945 41.353 1.00 30.96 A O原子1283 CG2 THR A 193 52.620 40.173 41.630 1.00 31.06 A C原子1284 C THR A 193 50.035 38.296 43.776 1.00 33.51 A C原子1285 O THR A 193 49.732 38.922 44.792 1.00 33.85 A O原子1286 N ALA A 194 49.332 37.271 43.295 1.00 32.21 A N原子1287 CA ALA A 194 48.024 36.848 43.803 1.00 30.97 A C原子1288 CB ALA A 194 48.101 36.400 45.251 1.00 30.54 A C原子1289 C ALA A 194 47.003 37.961 43.623 1.00 30.28 A C原子1290 O ALA A 194 46.062 38.108 44.392 1.00 32.52 A O原子1291 N VAL A 195 47.204 38.736 42.573 1.00 29.44 A N原子1292 CA VAL A 195 46.330 39.836 42.228 1.00 29.45 A C原子1293 CB VAL A 195 47.101 40.962 41.499 1.00 31.02 A C原子1294 CG1 VAL A 195 46.125 41.922 40.780 1.00 30.06 A C原子1295 CG2 VAL A 195 47.974 41.719 42.511 1.00 31.20 A C原子1296 C VAL A 195 45.222 39.351 41.330 1.00 28.12 A C原子1297 O VAL A 195 45.468 38.741 40.301 1.00 28.23 A O原子1298 N LEU A 196 44.002 39.661 41.735 1.00 26.08 A N原子1299 CA LEU A 196 42.817 39.295 41.004 1.00 24.78 A C原子1300 CB LEU A 196 41.809 38.700 41.982 1.00 24.48 A C原子1301 CG LEU A 196 40.434 38.320 41.448 1.00 23.75 A C原子1302 CD1 LEU A 196 39.876 37.168 42.282 1.00 27.10 A C原子1303 CD2 LEU A 196 39.535 39.534 41.499 1.00 23.28 A C原子1304 C LEU A 196 42.231 40.524 40.330 1.00 25.58 A C原子1305 O LEU A 196 42.178 41.589 40.931 1.00 30.48 A O原子1306 N LYS A 197 41.776 40.354 39.090 1.00 26.26 A N原子1307 CA LYS A 197 41.146 41.413 38.275 1.00 24.81 A C原子1308 CB LYS A 197 42.035 41.818 37.089 1.00 21.80 A C
原子1309 CG LYS A 197 43.402 42.425 37.444 1.00 26.31 A C原子1310 CD LYS A 197 43.294 43.704 38.276 1.00 29.08 A C.
原子1311 CE LYS A 197 44.634 44.418 38.417 1.00 30.93 A C原子1312 NZ LYS A 197 45.217 44.567 37.062 1.00 37.10 A N原子1313 C LYS A 197 39.814 40.903 37.712 1.00 25.33 A C原子1314 O LYS A 197 39.776 39.921 36.977 1.00 25.96 A O原子1315 N LEU A 198 38.726 41.576 38.063 1.00 26.02 A N原子1316 CA LEU A 198 37.409 41.215 37.582 1.00 24.94 A C原子1317 CB LEU A 198 36.355 42.041 38.313 1.00 27.25 A C原子1318 CG LEU A 198 34.992 41.470 38.710 1.00 28.56 A C原子1319 CD1 LEU A 198 34.010 42.625 38.860 1.00 26.58 A C原子1320 CD2 LEU A 198 34.488 40.491 37.678 1.00 29.04 A C原子1321 C LEU A 198 37.358 41.589 36.109 1.00 25.54 A C原子1322 O LEU A 198 37.905 42.611 35.712 1.00 23.47 A O原子1323 N CYS A 199 36.701 40.761 35.303 1.00 27.06 A N原子1324 CA CYS A 199 36.546 41.053 33.890 1.00 26.95 A C原子1325 CB CYS A 199 37.664 40.435 33.047 1.00 27.29 A C原子1326 SG CYS A 199 37.600 38.675 32.727 1.00 27.04 A S原子1327 C CYS A 199 35.168 40.688 33.353 1.00 28.18 A C原子1328 O CYS A 199 34.245 40.407 34.135 1.00 24.57 A O原子1329 N ASP A 200 35.057 40.739 32.017 1.00 30.94 A N原子1330 CA ASP A 200 33.845 40.486 31.230 1.00 30.60 A C原子1331 CB ASP A 200 33.474 39.003 31.109 1.00 31.99 A C原子1332 CG ASP A 200 32.232 38.777 30.209 1.00 35.20 A C原子1333 OD1 ASP A 200 31.350 37.964 30.567 1.00 36.52 A O原子1334 OD2 ASP A 200 32.117 39.421 29.134 1.00 39.61 A O原子1335 C ASP A 200 32.672 41.251 31.775 1.00 32.71 A C原子1336 O ASP A 200 32.003 40.798 32.702 1.00 33.36 A O
原子1337 N PHE A 201 32.432 42.430 31.216 1.00 34.02 A N原子1338 CA PHE A 201 31.296 43.242 31.642 1.00 37.31 A C原子1339 CB PHE A 201 31.774 44.655 31.991 1.00 36.67 A C原子1340 CG PHE A 201 32.506 44.726 33.302 1.00 34.55 A C原子1341 CD1 PHE A 201 33.862 44.434 33.376 1.00 34.34 A C原子1342 CD2 PHE A 201 31.829 45.073 34.471 1.00 35.02 A C原子1343 CE1 PHE A 201 34.534 44.480 34.594 1.00 31.36 A C原子1344 CE2 PHE A 201 32.489 45.123 35.691 1.00 34.05 A C原子1345 CZ PHE A 201 33.851 44.826 35.751 1.00 31.93 A C原子1346 C PHE A 201 30.177 43.236 30.584 1.00 38.92 A C原子1347 O PHE A 201 29.297 44.103 30.562 1.00 38.59 A O原子1348 N GLY A 202 30.203 42.200 29.750 1.00 41.08 A N原子1349 CA GLY A 202 29.232 42.057 28.686 1.00 45.08 A C原子1350 C GLY A 202 27.800 41.828 29.139 1.00 47.51 A C原子1351 O GLY A 202 26.863 41.996 28.351 1.00 50.35 A O原子1352 N SER A 203 27.622 41.432 30.397 1.00 48.34 A N原子1353 CA SER A 203 26.288 41.181 30.934 1.00 47.92 A C原子1354 CB SER A 203 26.186 39.744 31.488 1.00 49.53 A C原子1355 OG SER A 203 26.524 38.768 30.509 1.00 50.50 A O原子1356 C SER A 203 26.032 42.192 32.048 1.00 48.85 A C原子1357 O SER A 203 25.037 42.102 32.781 1.00 48.61 A O原子1358 N ALA A 204 26.957 43.143 32.182 1.00 48.52 A N原子1359 CA ALA A 204 26.856 44.186 33.199 1.00 47.92 A C原子1360 CB ALA A 204 28.208 44.890 33.369 1.00 48.73 A C原子1361 C ALA A 204 25.776 45.202 32.856 1.00 46.94 A C原子1362 O ALA A 204 25.525 45.498 31.680 1.00 46.50 A O原子1363 N LYS A 205 25.159 45.752 33.893 1.00 46.53 A N原子1364 CA LYS A 205 24.121 46.737 33.702 1.00 48.03 A C
原子1365 CB LYS A 205 22.838 46.052 33.221 1.00 49.84 A C原子1366 CG LYS A 205 21.665 46.999 33.043 1.00 52.67 A C原子1367 CD LYS A 205 20.336 46.267 33.015 1.00 54.12 A C原子1368 CE LYS A 205 19.281 46.991 33.873 1.00 55.97 A C原子1369 NZ LYS A 205 17.891 46.432 33.715 1.00 51.58 A N原子1370 C LYS A 205 23.843 47.508 34.986 1.00 48.17 A C原子1371 O LYS A 205 23.662 46.913 36.052 1.00 45.43 A O原子1372 N GLN A 206 23.835 48.838 34.890 1.00 50.42 A N原子1373 CA GLN A 206 23.537 49.656 36.060 1.00 51.09 A C原子1374 CB GLN A 206 23.802 51.138 35.812 1.00 51.00 A C原子1375 CG GLN A 206 23.638 51.964 37.074 1.00 55.43 A C原子1376 CD GLN A 206 23.668 53.464 36.832 1.00 58.62 A C原子1377 OE1 GLN A 206 23.219 54.238 37.682 1.00 60.73 A O原子1378 NE2 GLN A 206 24.196 53.886 35.677 1.00 58.59 A N原子1379 C GLN A 206 22.064 49.437 36.309 1.00 51.56 A C原子1380 O GLN A 206 21.234 49.629 35.416 1.00 52.14 A O原子1381 N LEU A 207 21.750 48.963 37.503 1.00 53.49 A N原子1382 CA LEU A 207 20.372 48.694 37.861 1.00 55.48 A C原子1383 CB LEU A 207 20.300 47.547 38.874 1.00 52.46 A C原子1384 CG LEU A 207 20.966 46.208 38.531 1.00 50.81 A C原子1385 CD1 LEU A 207 20.413 45.156 39.482 1.00 50.23 A C原子1386 CD2 LEU A 207 20.738 45.798 37.071 1.00 48.02 A C原子1387 C LEU A 207 19.718 49.942 38.446 1.00 59.23 A C原子1388 O LEU A 207 20.384 50.743 39.123 1.00 58.87 A O原子1389 N VAL A 208 18.418 50.095 38.163 1.00 62.57 A N原子1390 CA VAL A 208 17.590 51.215 38.642 1.00 64.00 A C原子1391 CB VAL A 208 17.519 52.363 37.605 1.00 62.01 A C原子1392 CG1 VAL A 208 17.474 51.802 36.198 1.00 61.19 A C
原子1393 CG2 VAL A 208 16.299 53.212 37.864 1.00 61.93 A C原子1394 C VAL A 208 16.182 50.693 38.901 1.00 65.50 A C原子1395 O VAL A 208 15.686 49.880 38.122 1.00 66.73 A O原子1396 N ARG A 209 15.551 51.131 39.994 1.00 67.63 A N原子1397 CA ARG A 209 14.198 50.670 40.319 1.00 69.71 A C原子1398 CB ARG A 209 13.755 51.108 41.721 1.00 72.23 A C原子1399 CG ASRG A 209 13.539 52.608 41.907 1.00 75.01 A C原子1400 CD ARG A 209 14.846 53.370 41.838 1.00 77.95 A C原子1401 NE ARG A 209 14.712 54.747 42.310 1.00 80.82 AN原子1402 CZ ARG A 209 15.377 55.779 41.798 1.00 81.99 A C原子1403 NH1 ARG A 209 16.220 55.592 40.787 1.00 81.89 A N原子1404 NH2 ARG A 209 15.225 56.993 42.318 1.00 83.70 A N原子1405 C ARG A 209 13.224 51.189 39.285 1.00 69.54 A C原子1406 O ARG A 209 13.281 52.360 38.898 1.00 69.25 A O原子1407 N GLY A 210 12.344 50.306 38.826 1.00 69.42 A N原子1408 CA GLY A 210 11.383 50.694 37.815 1.00 69.06 A C原子1409 C GLY A 210 11.756 50.171 36.440 1.00 68.46 A C原子1410 O GLY A 210 10.878 49.792 35.673 1.00 69.37 A O原子1411 N GLU A 211 13.041 50.193 36.096 1.00 66.88 A N原子1412 CA GLU A 211 13.481 49.677 34.799 1.00 66.19 A C原子1413 CB GLU A 211 14.687 50.480 34.287 1.00 67.27 A C原子1414 CG GLU A 211 14.414 52.001 34.244 1.00 67.78 A C原子1415 CD GLU A 211 15.365 52.786 33.327 1.00 68.52 A C原子1416 OE1 GLU A 211 16.595 52.645 33.487 1.00 67.46 A O原子1417 OE2 GLU A 211 14.885 53.554 32.450 1.00 69.67 A O原子1418 C GLU A 211 13.788 48.180 35.004 1.00 65.00 A C原子1419 O GLU A 211 14.675 47.815 35.776 1.00 65.37 A O原子1420 N PRO A 212 13.011 47.299 34.348 1.00 63.55 A N
原子1421 CD PRO A 212 11.977 47.679 33.369 1.00 64.19 A C原子1422 CA PRO A 212 13.118 45.840 34.420 1.00 61.55 A C原子1423 CB PRO A 212 11.750 45.390 33.938 1.00 61.93 A C原子1424 CG PRO A 212 11.555 46.315 32.778 1.00 63.79 A C原子1425 C PRO A 212 14.218 45.200 33.594 1.00 59.49 A C原子1426 O PRO A 212 14.383 45.475 32.405 1.00 59.70 A O原子1427 N ASN A 213 14.856 44.221 34.224 1.L00 57.24 A N原子1428 CA ASN A 213 15.965 43.476 33.652 1.00 52.53 A C原子1429 CB ASN A 213 17.184 43.635 34.569 1.00 50.18 A C原子1430 CG ASN A 213 16.966 44.683 35.665 1.00 48.59 A C原子1431 OD1 ASN A 213 17.436 45.821 35.566 1.00 48.28 A O原子1432 ND2 ASN A 213 16.218 44.308 36.699 1.00 46.52 A N原子1433 C ASN A 213 15.590 41.997 33.534 1.00 50.89 A C原子1434 O ASN A 213 14.796 41.493 34.336 1.00 50.48 A O原子1435 N VAL A 214 16.167 41.309 32.543 1.00 48.62 A N原子1436 CA VAL A 214 15.905 39.880 32.309 1.00 45.70 A C原子1437 CB VAL A 214 16.723 39.312 31.143 1.00 44.23 A C原子1438 CG1 VAL A 214 15.949 39.402 29.867 1.00 45.41 A C原子1439 CG2 VAL A 214 18.039 40.027 31.045 1.00 40.36 A C原子1440 C VAL A 214 16.211 38.975 33.488 1.00 44.58 A C原子1441 O VAL A 214 17.195 39.179 34.204 1.00 44.08 A O原子1442 N SER A 215 15.379 37.948 33.646 1.00 43.51 A N原子1443 CA SERA 215 15.541 36.965 34.702 1.00 41.53 A C原子1444 CB SERA 215 14.224 36.262 34.960 1.00 40.28 A C原子1445 OG SERA 215 13.244 37.187 35.349 1.00 44.40 A O原子1446 C SER A 215 16.564 35.937 34.234 1.00 40.92 A C原子1447 O SER A 215 17.394 35.482 35.015 1.00 41.15 A O原子1448 N PTR A 216 16.474 35.551 32.963 1.00 40.14 A N
原子1449 CA PTR A 216 17.401 34.578 32.409 1.00 40.46 A C原子1450 CB PTR A 216 16.848 33.925 31.141 1.00 40.63 A C原子1451 CG PTR A 216 17.534 32.603 30.821 1.00 40.78 A C原子1452 CD1 PTR A 216 17.136 31.432 31.450 1.00 41.37 A C原子1453 CE1 PTR A 216 17.759 30.216 31.187 1.00 41.30 A C原子1454 CD2 PTR A 216 18.584 32.524 29.918 1.00 38.09 A C原子1455 CE2 PTR A 216 19.219 31.304 29.650 1.00 38.06 A C原子1456 CZ PTR A 216 18.799 30.150 30.288 1.00 39.44 A C原子1457 OH PTR A 216 19.360 28.905 29.996 1.00 41.40 A O原子1458 C PTR A 216 18.719 35.248 32.092 1.00 41.06 A C原子1459 O PTR A 216 18.988 35.604 30.943 1.00 41.01 A O原子1460 P PTR A 216 20.633 28.391 30.790 1.00 38.82 A P原子1461 O1 PPTR A 216 21.164 27.232 29.920 1.00 38.25 A O原子1462 O2 PPTR A 216 20.052 27.820 32.128 1.00 35.47 A O原子1463 O3 PPTR A 216 21.677 29.458 31.002 1.00 35.59 A O原子1464 N ILE A 217 19.532 35.420 33.128 1.00 41.67 A N原子1465 CA ILE A 217 20.840 36.061 33.014 1.00 41.37 A C原子1466 CB ILE A 217 20.728 37.589 33.302 1.00 38.71 A C原子1467 CG2 ILE A 217 20.540 37.837 34.788 1.00 35.11 A C原子1468 CG1 ILE A 217 21.989 38.316 32.827 1.00 39.70 A C原子1469 CD1 ILE A 217 22.306 38.150 31.349 1.00 36.80 A C原子1470 C ILE A 217 21.782 35.407 34.042 1.00 43.45 A C原子1471 O ILE A 217 21.310 34.814 35.028 1.00 43.91 A O原子1472 N CYS A 218 23.096 35.490 33.797 1.00 43.60 A N原子1473 CA CYS A 218 24.108 34.920 34.705 1.00 42.50 A C原子1474 CB CYS A 218 23.701 35.166 36.173 1.00 40.92 A C原子1475 SG CYS A 218 24.917 34.666 37.397 1.00 47.75 A S原子1476 C CYS A 218 24.327 33.425 34.453 1.00 40.80 A C
原子1477 O CYS A 218 23.365 32.690 34.236 1.00 42.78 A O原子1478 N SER A 219 25.588 32.986 34.451 1.00 38.62 A N原子1479 CA SER A 219 25.913 31.577 34.219 1.00 34.41 A C原子1480 CB SER A 219 27.413 31.330 34.330 1.00 34.07 A C原子1481 OG SER A 219 28.047 31.609 33.098 1.00 37.97 A O原子1482 C SER A 219 25.156 30.656 35.153 1.00 31.88 A C原子1483 O SER A 219 25.235 30.792 36.379 1.00 31.16 A O原子1484 N ARG A 220 24.497 29.664 34.557 1.00 29.33 A N原子1485 CA ARG A 220 23.654 28.710 35.285 1.00 27.16 A C原子1486 CB ARG A 220 23.324 27.478 34.435 1.00 28.01 A C原子1487 CG ARG A 220 22.183 26.644 35.022 1.00 29.01 A C原子1488 CD ARG A 220 22.117 25.265 34.364 1.00 33.09 A C原子1489 NE ARG A 220 21.904 25.346 32.919 1.00 34.89 A N原子1490 CZ ARG A 220 22.335 24.463 32.020 1.00 33.04 A C原子1491 NH1 ARG A 220 23.023 23.391 32.384 1.00 34.49 A N原子1492 NH2 ARG A 220 22.080 24.673 30.740 1.00 33.47 A N原子1493 C&APOS；ARG A 220 24.055 28.250 36.675 1.00 24.73 A C原子1494 O ARG A 220 23.247 28.325 37.577 1.00 24.64 A O原子1495 N TYR A 221 25.262 27.722 36.830 1.00 22.54 A N原子1496 CA TYR A 221 25.712 2./231 38.121 1.00 23.80 A C原子1497 CB TYR A 221 27.070 26.539 37.974 1.00 23.89 A C原子1498 CG TYR A 221 27.124 25.341 37.044 1.00 28.24 A C原子1499 CD1 TYR A 221 28.340 24.765 36.744 1.00 30.22 A C原子1500 CE1 TYR A 221 28.443 23.649 35.955 1.00 31.53 A C原子1501 CD2 TYR A 221 25.981 24.759 36.508 1.00 28.46 A C原子1502 CE2 TYR A 221 26.070 23.628 35.699 1.00 29.73 A C原子1503 CZ TYR A 221 27.326 23.071 35.433 1.00 31.40 A C原子1504 OH TYR A 221 27.513 21.911 34.687 1.00 34.11 A O
原子1505 C TYR A 221 25.833 28.336 39.181 1.00 23.02 A C原子1506 O TYR A 221 25.752 28.072 40.369 1.00 20.91 A O原子1507 N TYR A 222 26.054 29.568 38.743 1.00 24.21 A N原子1508 CA TYR A 222 26.246 30.688 39.658 1.00 24.73 A C原子1509 CB TYR A 222 27.522 31.463 39.241 1.00 22.79 A C原子1510 CG TYR A 222 28.724 30.554 38.965 1.00 22.45 A C原子1511 CD1 TYR A 222 29.609 30.193 39.985 1.00 21.00 A C原子1512 CE1 TYR A 222 30.632 29.245 39.769 1.00 20.63 A C原子1513 CD2 TYR A 222 28.903 29.960 37.713 1.00 19.14 A C原子1514 CE2 TYR A 222 29.913 29.017 37.499 1.00 18.85 A C原子1515 CZ TYR A 222 30.770 28.649 38.519 1.00 19.59 A C原子1516 OH TYR A 222 31.691 27.631 38.318 1.00 16.40 A O原子1517 C TYR A 222 25.022 31.610 39.722 1.00 24.44 A C原子1518 O TYR A 222 25.037 32.640 40.397 1.00 26.04 A O原子1519 N ARG A 223 23.942 31.191 39.070 1.00 24.33 A N原子1520 CA ARG A 223 22.706 31.958 39.021 1.00 23.24 A C原子1521 CB ARG A 223 21.818 31.395 37.933 1.00 25.82 A C原子1522 CG ARG A 223 20.589 32.224 37.663 1.00 28.19 A C原子1523 CD ARG A 223 19.841 31.661 36.469 1.00 29.16 A C原子1524 NE ARG A 223 20.627 31.758 35.238 1.00 30.38 A N原子1525 CZ ARG A 223 20.579 30.874 34.253 1.00 28.67 A C原子1526 NH1 ARG A 223 19.782 29.803 34.356 1.00 30.82 A N原子1527 NH2 ARG A 223 21.296 31.089 33.150 1.00 29.60 A N原子1528 C ARG A 223 21.944 31.942 40.343 1.00 25.78 A C原子1529 O ARG A 223 21.648 30.865 40.875 1.00 28.11 A O原子1530 N ALA A 224 21.582 33.125 40.836 1.00 25.24 A N原子1531 CA ALA A 224 20.844 33.251 42.098 1.00 27.32 A C原子1532 CB ALA A 224 20.769 34.710 42.522 1.00 26.42 A C
原子1533 C ALA A 224 19.448 32.688 41.957 1.00 28.09 A C原子1534 O ALA A 224 18.864 32.775 40.883 1.00 29.27 A O原子1535 N PRO A 225 18.860 32.181 43.057 1.00 29.46 A N原子1536 CD PRO A 225 19.357 32.195 44.441 1.00 31.14 A C原子1537 CA PRO A 225 17.506 31.615 43.005 1.00 31.01 A C原子1538 CB PRO A 225 17.301 31.093 44.430 1.00 31.05 A C原子1539 CG PRO A 225 18.074 32.059 45.243 1.00 30.52 A C原子1540 C PRO A 225 16.421 32.612 42.527 1.00 33.71 A C原子1541 O PRO A 225 15.570 32.240 41.720 1.00 33.75 A O原子1542 N GLU A 226 16.481 33.877 42.960 1.00 36.24 A N原子1543 CA GLU A 226 15.510 34.875 42.486 1.00 37.76 A C原子1544 CB GLU A 226 15.963 36.325 42.744 1.00 39.65 A C原子1545 CG GLU A 226 16.445 36.679 44.109 1.00 40.28 A C原子1546 CD GLU A 226 17.937 36.487 44.247 1.00 39.21 A C原子1547 OE1 GLU A 226 18.710 37.361 43.771 1.00 40.55 A O原子1548 OE2 GLU A 226 18.321 35.455 44.837 1.00 35.91 A O原子1549 C GLU A 226 15.362 34.769 40.966 1.00 37.11 A C原子1550 O GLU A 226 14.263 34.806 40.441 1.00 37.86 A O原子1551 N LEU A 227 16.488 34.755 40.264 1.00 38.01 A N原子1552 CA LEU A 227 16.494 34.675 38.812 1.00 39.83 A C原子1553 CB LEU A 227 17.935 34.682 38.305 1.00 39.84 A C原子1554 CG LEU A 227 18.763 35.952 38.408 1.00 40.58 A C原子1555 CD1 LEU A 227 18.050 37.070 37.664 1.00 42.21 A C原子1556 CD2 LEU A 227 18.984 36.297 39.858 1.00 41.30 A C原子1557 C LEU A 227 15.790 33.422 38.275 1.00 41.64 A C原子1558 O LEU A 227 15.231 33.427 37.163 1.00 40.70 A O原子1559 N ILE A 228 15.883 32.338 39.045 1.00 42.13 A N原子1560 CA ILE A 228 15.288 31.053 38.677 1.00 41.98 A C
原子1561 CB ILE A 228 15.943 29.911 39.504 1.00 41.07 A C原子1562 CG2 ILE A 228 15.548 28.550 38.948 1.00 40.33 A C原子1563 CG1 ILE A 228 17.471 30.051 39.429 1.00 38.76 A C原子1564 CD1 ILE A 228 18.226 29.081 40.281 1.00 37.40 A C原子1565 C ILE A 228 13.750 31.101 38.821 1.00 41.98 A C原子1566 O ILE A 228 13.021 30.462 38.048 1.00 43.60 A O原子1567 N PHE A 229 13.283 31.919 39.768 1.00 39.71 A N原子1568 CA PHE A 229 11.859 32.148 40.038 1.00 38.89 A C原子1569 CB PHE A 229 11.614 32.418 41.515 1.00 35.12 A C原子1570 CG PHE A 229 11.615 31.187 42.353 1.00 37.40 A C原子1571 CD1 PHE A 229 12.760 30.785 43.017 1.00 35.70 A C原子1572 CD2 PHE A 229 10.449 30.454 42.527 1.00 39.78 A C原子1573 CE1 PHE A 229 12.749 29.683 43.848 1.00 38.38 A C原子1574 CE2 PHE A 229 10.422 29.339 43.363 1.00 41.77 A C原子1575 CZ PHE A 229 11.574 28.954 44.028 1.00 40.44 A C原子1576 C PHE A 229 11.298 33.312 39.224 1.00 40.12 A C原子1577 O PHE A 229 10.226 33.837 39.531 1.00 41.20 A O原子1578 N GLY A 230 12.073 33.765 38.245 1.00 41.63 A N原子1579 CA GLY A 230 11.636 34.834 37.359 1.00 43.05 A C原子1580 C GLY A 230 11.640 36.302 37.761 1.00 43.47 A C原子1581 O GLY A 230 11.105 37.128 37.006 1.00 43.20 A O原子1582 N ALA A 231 12.220 36.640 38.914 1.00 43.29 A N原子1583 CA ALA A 231 12.260 38.028 39.360 1.00 42.22 A C原子1584 CB ALA A 231 13.033 38.140 40.668 1.00 41.84 A C原子1585 C ALA A 231 12.902 38.894 38.276 1.00 44.04 A C原子1586 O ALA A 231 13.803 38.439 37.544 1.00 45.16 A O原子1587 N THR A 232 12.392 40.118 38.130 1.00 44.50 A N原子1588 CA THR A 232 12.908 41.072 37.139 1.00 43.69 A C
原子1589 CB THR A 232 11.877 41.338 35.998 1.00 43.60 A C原子1590 OG1 THR A 232 10.547 41.302 36.534 1.00 43.96 A O原子1591 CG2 THR A 232 12.002 40.308 34.878 1.00 42.69 A C原子1592 C THR A 232 13.215 42.374 37.881 1.00 43.92 A C原子1593 O THR A 232 13.717 43.340 37.293 1.00 43.42 A O原子1594 N ASP A 233 12.912 42.353 39.184 1.00 45.51 A N原子1595 CA ASP A 233 13.105 43.471 40.121 100 48.09 A C原子1596 CB ASP A 233 11.804 43.747 40.899 1.00 52.12 A C原子1597 CG ASP A 233 11.326 42.528 41.735 1.00 56.77 A C原子1598 OD1 ASP A 233 11.244 41.406 41.170 1.00 57.99 A O原子1599 OD2 ASP A 233 11.012 42.697 42.951 1.00 58.75 A O原子1600 C ASP A 233 14.190 43.103 41.127 1.00 47.45 A C原子1601 O ASP A 233 14.120 43.475 42.301 1.00 47.30 A O原子1602 N TYR A 234 15.188 42.360 40.659 1.00 47.32 A N原子1603 CA TYR A 234 16.284 41.895 41.503 1.00 45.77 A C原子1604 CB TYR A 234 16.889 40.616 40.905 1.00 41.41 A C原子1605 CG TYR A 234 17.382 40.751 39.479 1.00 36.80 A C原子1606 CD1 TYR A 234 18.671 41.195 39.205 1.00 35.39 A C原子1607 CE1 TYR A 234 19.135 41.292 37.910 1.00 31.99 A C原子1608 CD2 TYR A 234 16.573 40.409 38.411 1.00 35.34 A C原子1609 CE2 TYR A 234 17.026 40.505 37.109 1.00 33.26 A C原子1610 CZ TYR A 234 18.312 40.947 36.856 1.00 32.63 A C原子1611 OH TYR A 234 18.776 41.051 35.541 1.00 32.50 A O原子1612 C TYR A 234 17.379 42.929 41.795 1.00 46.81 A C原子1613 O TYR A 234 17.541 43.924 41.072 1.00 47.03 A O原子1614 N THR A 235 18.120 42.690 42.871 1.00 47.19 A N原子1615 CA THR A 235 19.188 43.596 43.253 1.00 46.66 A C原子1616 CB THR A 235 19.195 43.780 44.778 1.00 48.48 A C
原子1617 OG1 THR A 235 18.980 42.519 45.430 1.00 51.51 A O原子1618 CG2 THR A 235 18.076 44.704 45.168 1.00 50.02 A C原子1619 C THR A 235 20.584 43.222 42.720 1.00 46.29 A C原子1620 O THR A 235 20.718 42.506 41.714 1.00 45.29 A O原子1621 N SER A 236 21.617 43.791 43.343 1.00 44.53 A N原子1622 CA SER A 236 23.008 43.521 42.967 1.00 41.78 A C原子1623 CB SER A 236 23.884 44.760 43.161 1.00 39.95 A C原子1624 OG SER A 236 23.836 45.198 44.508 1.00 45.19 A O原子1625 C SER A 236 23.511 42.366 43.831 1.00 38.89 A C原子1626 O SER A 236 24.616 41.862 43.633 1.00 38.04 A O原子1627 N SER A 237 22.677 41.964 44.789 1.00 35.99 A N原子1628 CA SER A 237 22.976 40.850 45.668 1.00 34.52 A C原子1629 CB SER A 237 21.988 40.800 46.833 1.00 33.62 A C原子1630 OG SER A 237 20.663 40.726 46.357 1.00 35.66 A O原子1631 C SER A 237 22.951 39.519 44.894 1.00 32.95 A C原子1632 O SER A 237 23.123 38.457 45.487 1.00 33.79 A O原子1633 N ILE A 238 22.684 39.570 43.587 1.00 31.53 A N原子1634 CA ILE A 238 22.702 38.355 42.763 1.00 30.22 A C原子1635 CB ILE A 238 22.012 38.536 41.356 1.00 26.21 A C原子1636 CG2 ILE A 238 20.537 38.803 41.518 1.00 29.08 A C原子1637 CG1 ILE A 238 22.656 39.659 40.555 1.00 26.02 A C原子1638 CD1 ILE A 238 22.093 39.796 39.182 1.00 26.47 A C原子1639 C ILE A 238 24.191 37.985 42.604 1.00 30.52 A C原子1640 O ILE A 238 24.548 36.802 42.508 1.00 31.51 A O原子1641 N ASP A 239 25.040 39.022 42.620 1.00 30.54 A N原子1642 CA ASP A 239 26.490 38.887 42.522 1.00 26.94 A C原子1643 CB ASP A 239 27.169 40.244 42.288 1.00 27.41 A C原子1644 CG ASP A 239 26.994 40.752 40.875 1.00 27.90 A C
原子1645 OD1 ASP A 239 26.559 39.972 40.005 1.00 29.28 A O原子1646 OD2 ASP A 239 27.307 41936 40.620 1.00 30.96 A O原子1647 C ASP A 239 26.991 38.290 43.823 1.00 25.46 A C原子1648 O ASP A 239 27.938 37.524 43.826 1.00 25.21 A O原子1649 N VAL A 240 26.374 38.646 44.940 1.00 24.64 A N原子1650 CA VAL A 240 26.833 38.079 46.200 1.00 25.12 A C原子1651 CB VAL A 240 26.262 38.822 47.413 1.00 23.29 A C原子1652 CG1 VAL A 240 26.488 38.015 48.667 1.00 23.70 A C原子1653 CG2 VAL A 240 26.949 40.154 47.545 1.00 21.83 A C原子1654 C VAL A 240 26.522 36.584 46.237 1.00 24.34 A C原子1655 O VAL A 240 27.321 35.782 46.725 1.00 27.47 A O原子1656 N TRP A 241 25.383 36.198 45.679 1.00 24.52 A N原子1657 CA TRP A 241 25.034 34.785 45.609 1.00 23.05 A C原子1658 CB TRP A 241 23.648 34.607 44.986 1.00 24.31 A C原子1659 CG TRP A 241 23.330 33.166 44.670 1.00 23.07 A C原子1660 CD2 TRP A 241 22.601 32.246 45.488 1.00 22.44 A C原子1661 CE2 TRP A 241 22.621 30.997 44.837 1.00 23.53 A C原子1662 CE3 TRP A 241 21.938 32.353 46.704 1.00 22.25 A C原子1663 CD1 TRP A 241 23.740 32.458 43.576 1.00 24.37 A C原子1664 NE1 TRP A 241 23.323 31.152 43.671 1.00 23.84 A N原子1665 CZ2 TRP A 241 22.005 29.867 45.376 1.00 22.52 A C原子1666 CZ3 TRP A 241 21.331 31.234 47.230 1.00 22.17 A C原子1667 CH2 TRP A 241 21.366 30.013 46.572 1.00 23.92 A C原子1668 C TRP A 241 26.080 34.098 44.717 1.00 22.93 A C原子1669 O TRP A 241 26.643 33.066 45.083 1.00 23.57 A O原子1670 N SER A 242 26.337 34.689 43.549 1.00 21.92 A N原子1671 CA SER A 242 27.321 34.160 42.605 1.00 23.80 A C原子1672 CB SER A 242 27.444 35.081 41.404 1.00 22.23 A C
原子1673 OG SER A 242 26.222 35.126 40.708 1.00 24.61 A O原子1674 C SER A 242 28.697 33.997 43.239 1.00 24.81 A C原子1675 O SER A 242 29.378 33.007 42.998 1.00 24.82 A O原子1676 N ALA A 243 29.105 34.997 44.024 1.00 26.07 A N原子1677 CA ALA A 243 30.390 34.988 44.711 1.00 24.84 A C原子1678 CB ALA A 243 30.642 36.325 45.391 1.00 25.84 A C原子1679 C ALA A 243 30.386 33.862 45.726 1.00 24.61 A C原子1680 O ALA A 243 31.406 33.224 45.926 1.00 26.65 A O原子1681 N GLY A 244 29.246 33.633 46.379 1.00 25.37 A N原子1682 CA GLY A 244 29.148 32.546 47.349 1.00 24.68 A C原子1683 C GLY A 244 29.335 31.182 46.668 1.00 24.83 A C原子1684 O GLY A 244 29.874 30.254 47.257 1.00 25.31 A O原子1685 N CYS A 245 28.893 31.059 45.415 1.00 23.66 A N原子1686 CA CYS A 245 29.035 29.812 44.668 1.00 22.85 A C原子1687 CB CYS A 245 28.193 29.851 43.394 1.00 23.45 A C原子1688 SG CYS A 245 26.404 29.904 43.670 1.00 27.08 A S原子1689 C CYS A 245 30.505 29.580 44.320 1.00 23.15 A C原子1690 O CYS A 245 30.986 28.446 44.329 1.00 24.13 A O原子1691 N VAL A 246 31.212 30.663 43.993 1.00 23.76 A N原子1692 CA VAL A 246 32.632 30.589 43.665 1.00 19.75 A C原子1693 CB VAL A 246 33.177 31.950 43.234 1.00 18.39 A C原子1694 CG1 VAL A 246 34.668 31.848 43.030 1.00 17.77 A C原子1695 CG2 VAL A 246 32.488 32.421 41.957 1.00 17.97 A C原子1696 C VAL A 246 33.415 30.119 44.886 1.00 21.03 A C原子1697 O VAL A 246 34.285 29.250 44.797 1.00 19.93 A O原子1698 N LEU A 247 33.093 30.720 46.030 1.00 20.14 A N原子1699 CA LEU A 247 33.716 30.388 47.312 1.00 18.91 A C原子1700 CB LEU A 247 33.084 31.246 48.415 1.00 19.92 A C
原子1701 CG LEU A 247 33.429 30.747 49.810 1.00 22.16 A C原子1702 CD1 LEU A 247 34.924 30.909 50.050 1.00 22.30 A C原子1703 CD2 LEU A 247 32.604 31.482 50.839 1.00 24.26 A C原子1704 C LEU A 247 33.512 28.898 47.635 1.00 18.38 A C原子1705 O LEU A 247 34.468 28.168 47.884 1.00 19.50 A O原子1706 N ALA A 248 32.254 28.454 47.609 1.00 19.50 A N原子1707 CA ALA A 248 31.907 27.069 47.903 1.00 19.25 A C原子1708 CB ALA A 248 30.421 26.861 47.754 1.00 20.42 A C原子1709 C ALA A 248 32.661 26.139 46.968 1.00 20.69 A C原子1710 O ALA A 248 33.125 25.088 47.385 1.00 22.26 A O原子1711 N GLU A 249 32.781 26.549 45.706 1.00 20.13 A N原子1712 CA GLU A 249 33.480 25.782 44.665 1.00 20.03 A C原子1713 CB GLU A 249 33.270 26.471 43.318 1.00 18.13 A C原子1714 CG GLU A 249 34.094 25.902 42.190 1.00 16.32 A C原子1715 CD GLU A 249 33.549 26.339 40.833 1.00 22.40 A C原子1716 OE1 GLU A 249 32.363 26.786 40.773 1.00 21.31 A O原子1717 OE2 GLU A 249 34.304 26.225 39.829 1.00 26.86 A O原子1718 C GLU A 249 34.987 25.668 44.926 1.00 22.17 A C原子1719 O GLU A 249 35.603 24.631 44.653 1.00 22.61 A O原子1720 N LEU A 250 35.579 26.764 45.415 1.00 24.09 A N原子1721 CA LEU A 250 37.010 26.816 45.722 1.00 22.80 A C原子1722 CB LEU A 250 37.439 28.257 46.020 1.00 23.23.36 A C原子1723 CG LEU A 250 37.397 29.299 44.895 1.00 22.14 A C原子1724 CD1 LEU A 250 37.795 30.638 45.458 1.00 21.99 A C原子1725 CD2 LEU A 250 38.363 28.897 43.756 1.00 23.96 A C原子1726 C LEU A 250 37.306 25.915 46.909 1.00 23.35 A C原子1727 O LEU A 250 38.418 25.390 47.047 1.00 22.51 A O原子1728 N LEU A 251 36.297 25.757 47.768 1.00 25.45 A N
原子1729 CA LEU A 251 36.374 24.902 48.955 1.00 26.07 A C原子1730 CB LEU A 251 35.331 25.338 49.984 1.00 22.67 A C原子1731 CG LEU A 251 35.513 26.709 50.651 1.00 20.92 A C原子1732 CD1 LEU A 251 34.414 26.949 51.674 1.00 18.65 A C原子1733 CD2 LEU A 251 36.876 26.800 51.314 1.00 19.51 A C原子1734 C LEU A 251 36.145 23.421 48.608 1.00 28.24 A C原子1735 O LEU A 251 36.866 22.544 49.092 1.00 31.53 A O原子1736 N LEU A 252 35.154 23.152 47.761 1.00 28.65 A N原子1737 CA LEU A 252 34.807 21.783 47.367 1.00 28.70 A C原子1738 CB LEU A 252 33.374 21.703 46.819 1.00 29.15 A C原子1739 CG LEU A 252 32.184 21.983 47.734 1.00 32.55 A C原子1740 CD1 LEU A 252 30.921 22.157 46.891 1.00 31.58 A C原子1741 CD2 LEU A 252 32.018 20.853 48.731 1.00 32.33 A C原子1742 C LEU A 252 35.716 21.224 46.306 1.00 28.03 A C原子1743 O LEU A 252 35.969 20.017 46.278 1.00 28.89 A O原子1744 N GLY A 253 36.163 22.093 45.406 1.00 27.05 A N原子1745 CA GLY A 253 37.001 21.644 44.311 1.00 26.54 A C原子1746 C GLY A 253 36.158 21.287 43.082 1.00 26.63 A C原子1747 O GLY A 253 36.624 20.624 42.159 1.00 28.26 A O原子1748 N GLN A 254 34.902 21.719 43.086 1.00 26.69 A N原子1749 CA GLN A 254 33.948 21.483 41.998 1.00 28.53 A C原子1750 CB GLN A 254 33.485 20.024 41.980 1.00 31.61 A C原子1751 CG GLN A 254 32.590 19.627 43.135 1.00 34.67 A C原子1752 CD GLN A 254 32.630 18.139 43.398 1.00 38.01 A C原子1753 OE1 GLN A 254 31.888 17.378 42.788 1.00 42.67 A O原子1754 NE2 GLN A 254 33.505 17.714 44.311 1.00 38.91 A N原子1755 C GLN A 254 32.760 22.415 42.273 1.00 27.95 A C原子1756 O GLON A 254 32.516 22.802 43.422 1.00 31.13 A O
原子1757 N PRO A 255 32.037 22.830 41.230 1.00 25.57 A N原子1758 CD PRO A 255 32.218 22.606 39.790 1.00 24.89 A C原子1759 CA PRO A 255 30.909 23.730 41.500 1.00 25.85 A C原子1760 CB PRO A 255 30.299 23.964 40.110 1.00 24.39 A C原子1761 CG PRO A 255 30.817 22.807 39.279 1.00 26.35 A C原子1762 C PRO A 255 29.933 23.125 42.482 1.00 25.58 A C原子1763 O PRO A 255 29.694 21.928 42.441 1.00 27.24 A O原子1764 N ILE A 256 29.385 23.945 43.374 1.00 24.44 A N原子1765 CA ILE A 256 28.442 23.425 44.360 1.00 22.49 A C原子1766 CB ILE A 256 28.355 24.338 45.647 1.00 23.25 A C原子1767 CG2 ILE A 256 27.993 25.772 45.307 1.00 21.43 A C原子1768 CG1 ILE A 256 27.369 23740 46.669 1.00 23.68 A C原子1769 CD1 ILE A 256 27.268 24.535 47.989 1.00 22.45 A C原子1770 C ILE A 256 27.060 23.105 43.786 1.00 22.05 A C原子1771 O ILE A 256 26.447 22.117 44.167 1.00 20.94 A O原子1772 N PHE A 257 26.590 23.914 42.841 1.00 21.81 A N原子1773 CA PHE A 257 25.282 23.697 42.220 1.00 22.95 A C原子1774 CB PHE A 257 24.378 24.907 42.464 1.00 20.86 A C原子1775 CG PHE A 257 24.210 25.276 43.924 1.00 21.19 A C原子1776 CD1 PHE A 257 23.809 24.326 44.862 1.00 23.12 A C原子1777 CD2 PHE A 257 24.375 26.593 44.332 1.00 20.95 A C原子1778 CE1 PHE A 257 23.567 24.690 46.178 1.00 23.71 A C原子1779 CE2 PHE A 257 24.142 26.970 45.630 1.00 22.20 A C原子1780 CZ PHE A 257 23.735 26.018 46.559 1.00 24.57 A C原子1781 C PHE A 257 25.350 23.422 40.686 1.00 23.79 A C原子1782 O PHE A 257 25.110 24.307 39.868 1.00 24.10 A O原子1783 N PRO A 258 25.659 22.189 40.287 1.00 23.31 A N原子1784 CD PRO A 258 26.239 21.067 41.047 1.00 22.47 A C
原子1785 CA PRO A 258 25.724 21.936 38.859 1.00 24.12 A C原子1786 CB PRO A 258 26.736 20.797 38.786 1.00 22.05 A C原子1787 CG PRO A 258 26.394 20.001 39.992 1.00 22.01 A C原子1788 C PRO A 258 24.382 21.575 38.200 1.00 27.03 A C原子1789 O PRO A 258 24.158 20.434 37.809 1.00 31.26 A O原子1790 N GLY A 259 23.515 22.556 38.006 1.00 28.00 A N原子1791 CA GLY A 259 22.243 22.272 37.369 1.00 28.12 A C原子1792 C GLY A 259 22.403 21.903 35.904 1.00 30.21 A C原子1793 O GLY A 259 23.404 22.251 35.262 1.00 28.55 A O原子1794 N ASP A 260 21.417 21.182 35.381 1.00 33.14 A N原子1795 CA ASP A 260 21.411 20.746 33.979 1.00 36.83 A C原子1796 CB ASP A 260 20.973 19.295 33.879 1.00 39.67 A C原子1797 CG ASP A 260 22.046 18.338 34.321 1.00 43.41 A C原子1798 OD1 ASP A 260 21.697 17.184 34.641 1.00 49.07 A O原子1799 OD2 ASP A 260 23.236 18.724 34.338 1.00 45.58 A O原子1800 C ASP A 260 20.471 21.592 33.127 1.00 36.78 A C原子1801 O ASP A 260 20.449 21.480 31.897 1.00 37.91 A O原子1802 N SER A 261 19.702 22.437 33.802 1.00 34.36 A N原子1803 CA SER A 261 18.747 23.313 33.157 1.00 34.33 A C原子1804 CB SER A 261 17.524 22.510 32.747 1.00 35.79 A C原子1805 OG SER A 261 16.936 21.933 33.908 1.00 36.67 A O原子1806 C SER A 261 18.360 24.323 34.230 1.00 35.39 A C原子1807 O SER A 261 18.766 24.184 35.385 1.00 37.88 A O原子1808 N GLY A 262 17.566 25.322 33.859 1.00 34.13 A N原子1809 CA GLY A 262 17.155 26.331 34.814 1.00 32.25 A C原子1810 C GLY A 262 16.491 25.729 36.037 1.00 31.53 A C原子1811 O GLY A 262 16.791 26.120 37.163 1.00 31.96 A O原子1812 N VAL A 263 15.603 24.762 35.812 1.00 31.41 A N
原子1813 CA VAL A 263 14.893 24.095 36.906 1.00 31.51 A C原子1814 CB VAL A 263 13.661 23.270 36.394 1.00 31.95 A C原子1815 CG1 VAL A 263 12.830 22.774 37.579 1.00 29.08 A C原子1816 CG2 VAL A 263 12.815 24.094 35.428 1.00 31.08 A C原子1817 C VAL A 263 15.798 23.165 37.734 1.00 30.50 A C原子1818 O VAL A 263 15.784 23.211 38.967 1.00 29.12 A O原子1819 N ASP A 264 16.567 22.309 37.067 1.00 29.87 A N原子1820 CA ASP A 264 17.433 21.400 37.805 1.00 32.22 A C原子1821 CB ASP A 264 18.203 20.454 36.879 1.00 32.96 A C原子1822 CG ASP A 264 19.056 19.454 37.659 1.00 35.53 A C原子1823 OD1 ASP A 264 18.565 18.852 38.648 1.00 38.23 A O原子1824 OD2 ASP A 264 20.237 19.293 37.306 1.00 36.58 A O原子1825 C ASP A 264 18.405 22.184 38.669 1.00 32.04 A C原子1826 O ASP A 264 18.973 21.654 39.638 1.00 30.30 A O原子1827 N GLN A 265 18.615 23.442 38.288 1.00 32.04 A N原子1828 CA GLN A 265 19.511 24.327 39.032 1.00 32.07 A C原子1829 CB GLN A 265 19.708 25.656 38.274 1.00 29.80 A C原子1830 CG GLN A 265 20.699 26.629 38.932 1.00 27.71 A C原子1831 CD GLN A 265 22.093 26.057 39.066 1.00 26.15 A C原子1832 OE1 GLN A 265 22.783 26.309 40.055 1.00 28.18 A O原子1833 NE2 GLN A 265 22.520 25.291 38.068 1.00 26.11 A N原子1834 C GLN A 265 18.941 24.562 40.443 1.00 30.56 A C原子1835 O GLN A 265 19.658 24.440 41.434 1.00 28.26 A O原子1836 N LEU A 266 17.632 24.829 40.508 1.00 31.85 A N原子1837 CA LEU A 266 16.921 25.065 41.771 1.00 33.17 A C原子1838 CB LEU A 266 15.491 25.576 41.479 1.00 34.38 A C原子1839 CG LEU A 266 14.570 25.869 42.685 1.00 37.81 A C原子1840 CD1 LEU A 266 15.223 26.855 43.646 1.00 37.84 A C
原子1841 CD2 LEU A 266 13.206 26.390 42.217 1.00 36.24 A C原子1842 C LEU A 266 16.879 23.782 42.620 1.00 31.08 A C原子1843 O LEU A 266 16.986 23.825 43.840 1.00 31.37 A O原子1844 N VAL A 267 16.726 22.648 41.937 1.00 31.74 A N原子1845 CA VAL A 267 16.673 21.320 42.545 1.00 29.73 A C原子1846 CB VAL A 267 16.413 20.206 41.462 1.00 29.26 A C原子1847 CG1 VAL A 267 16.626 18.801 42.068 1.00 29.23 A C原子1848 CG2 VAL A 267 14.995 20.331 40.889 1.00 24.78 A C原子1849 C VAL A 267 18.000 21.029 43.213 1.00 29.61 A C原子1850 O VAL A 267 18.045 20.448 44.294 1.00 32.14 A O原子1851 N GLU A 268 19.067 21.430 42.524 1.00 27.95 A N原子1852 CA GLU A 268 20.456 21.267 42.937 1.00 28.15 A C原子1853 CB GLU A 268 21.344 21.686 41.776 1.00 28.98 A C原子1854 CG GLU A 268 22.701 21.108 41.825 1.00 35.29 A C原子1855 CD GLU A 268 22.684 19.614 41.688 1.00 37.88 A C原子1856 OE1 GLU A 268 21.809 19.105 40.954 1.00 43.08 A O原子1857 OE2 GLU A 268 23.547 18.954 42.305 1.00 39.33 A O原子1858 C GLU A 268 20.770 22.120 44.171 1.00 28.18 A C原子1859 O GLU A 268 21.594 21.752 45.027 1.00 28.17 A O原子1860 N ILE A 269 20.134 23.290 44.208 1.00 30.49 A N原子1861 CA ILE A 269 20.232 24.260 45.309 1.00 30.41 A C原子1862 CB ILE A 269 19.659 25.642 44.881 1.00 29.62 A C原子1863 CG2 ILE A 269 19.606 26.579 46.058 1.00 32.02 A C原子1864 CG1 ILE A 269 20.531 26.265 43.793 1.00 26.27 A C原子1865 CD 1 ILE A 269 19.945 27.497 43.173 1.00 25.57 A C原子1866 C ILE A 269 19.400 23.745 46.492 1.00 30.30 A C原子1867 O ILE A 269 19.774 23.920 47.649 1.00 32.10 A O原子1868 N ILE A 270 18.244 23.167 46.179 1.00 29.33 A N
原子1869 CA ILE A 270 17.365 22.596 47.184 1.00 31.81 A C原子1870 CB ILE A 270 15.995 22.145 46.542 1.00 30.88 A C原子1871 CG2 ILE A 270 15.236 21.203 47.491 1.00 27.47 A C原子1872 CG1 ILE A 270 15.161 23.397 46.187 1.00 28.47 A C原子1873 CD1 ILE A 270 13.913 23.170 45.394 1.00 26.46 A C原子1874 C ILE A 270 18.070 21.453 47.934 1.00 32.83 A C原子1875 O ILE A 270 17.938 21.325 49.151 1.00 33.58 A O原子1876 N LYS A 271 18.905 20.698 47.222 1.00 33.61 A N原子1877 CA LYS A 271 19.647 19.578 47.801 1.00 34.70 A C原子1878 CB LYS A 271 20.400 18.820 46.697 1.00 36.76 A C原子1879 CG LYS A 271 19.505 18.100 45.683 1.00 38.77 A C原子1880 CD LYS A 271 20.300 17.075 44.863 1.00 41.89 A C原子1881 CE LYS A 271 19.394 16.243 43.942 1.00 46.13 A C原子1882 NZ LYS A 271 18.949 16.931 42.676 1.00 48.67 A N原子1883 C LYS A 271 20.634 19.981 48.908 1.00 36.40 A C原子1884 O LYS A 271 21.272 19.132 49.545 1.00 36.44 A O原子1885 N VAL A 272 20.781 21.280 49.123 1.00 36.74 A N原子1886 CA VAL A 272 21.700 21.764 50.140 1.00 36.41 A C原子1887 CB VAL A 272 23.044 22.282 49.496 1.00 35.51 A C原子1888 CG1 VAL A 272 23.790 23.204 50.449 1.00 36.23 A C原子1889 CG2 VAL A 272 23.946 21.098 49.133 1.00 35.03 A C原子1890 C VAL A 272 20.996 22.824 50.985 1.00 36.49 A C原子1891 O VAL A 272 21.031 22.783 52.211 1.00 36.63 A O原子1892 N LEU A 273 20.283 23.729 50.335 1.00 36.62 A N原子1893 CA LEU A 273 19.572 24.769 51.069 1.00 37.50 A C原子1894 CB LEU A 273 19.462 26.018 50.200 1.00 36.90 A C原子1895 CG LEU A 273 20.617 26.976 50.397 1.00 37.23 A C原子1896 CD1 LEU A 273 20.421 28.228 49.549 1.00 38.59 A C
原子1897 CD2 LEU A 273 20.629 27.330 51.891 1.00 40.42 A C原子1898 C LEU A 273 18.178 24.339 51.545 1.00 39.19 A C原子1899 O LEU A 273 17.552 25.000 52.376 1.00 39.97 A O原子1900 N GLY A 274 17.686 23.228 51.010 1.00 39.40 A N原子1901 CA GLY A 274 16.362 22.778 51.380 1.00 37.58 A C原子1902 C GLY A 274 15.333 23.604 50.653 1.00 37.25 A C原子1903 O GLY A 274 15.651 24.645 50.097 1.00 37.82 A O原子1904 N THR A 275 14.090 23.140 50.657 1.00 39.11 A N原子1905 CA THR A 275 13.010 23.847 49.987 1.00 38.46 A C原子1906 CB THR A 275 11.737 23.033 50.071 1.00 39.29 A C原子1907 OG1 THR A 275 12.048 21.682 49.718 1.00 41.41 A O原子1908 CG2 THR A 275 10.689 23.559 49.091 1.00 43.20 A C原子1909 C THR A 275 12.793 25.208 50.605 1.00 37.05 A C原子1910 O THR A 275 12.752 25.343 51.815 1.00 37.12 A O原子1911 N PRO A 276 12.722 26.249 49.776 1.00 39.10 A N原子1912 CD PRO A 276 12.734 26.238 48.305 1.00 38.36 A C原子1913 CA PRO A 276 12.512 27.606 50.288 1.00 43.26 A C原子1914 CB PRO A 276 12.592 28.460 49.020 1.00 41.50 A C原子1915 CG PRO A 276 12.037 27.542 47.967 1.00 38.04 A C原子1916 C PRO A 276 11.123 27.695 50.906 1.00 47.74 A C原子1917 O PRO A 276 10.223 26.959 50.494 1.00 49.89 A O原子1918 N THR A 277 10.948 28.552 51.912 1.00 50.49 A N原子1919 CA THR A 277 9.631 28.702 52.521 1.00 52.46 A C原子1920 CB THR A 277 9.679 29.333 53.930 1.00 50.91 A C原子1921 OG1 THR A 277 10.105 30.696 53.837 1.00 49.30 A O原子1922 CG2 THR A 277 10.599 28.557 54.844 1.00 48.81 A C原子1923 C THR A 277 8.783 29.593 51.613 1.00 55.88 A C原子1924 O THR A 277 9.286 30.160 50.633 1.00 56.73 A O
原子1925 N ARG A 278 7.493 29.688 51.926 1.00 58.65 A N原子1926 CA ARG A 278 6.573 30.504 51.144 1.00 60.44 A C原子1927 CB ARG A 278 5.120 30.273 51.598 1.00 64.53 A C原子1928 CG ARG A 278 4.900 30.160 53.119 1.00 68.29 A C原子1929 CD ARG A 278 3.423 29.840 53.454 1.00 70.77 A C原子1930 NE ARG A 278 2.494 30.939 53.152 1.00 71.15 A N原子1931 CZ ARG A 278 1.837 31.094 52.002 1.00 71.31 A C原子1932 NH1 ARG A 278 1.994 30.222 51.012 1.00 71.08 A N原子1933 NH2 ARG A 278 1.014 32.126 51.846 1.00 71.56 A N原子1934 C ARG A 278 6.953 31.978 51.226 1.00 59.87 A C原子1935 O ARG A 278 6.760 32.726 50.270 1.00 58.41 A O原子1936 N GLU A 279 7.475 32.392 52.380 1.00 60.02 A N原子1937 CA GLU A 279 7.908 33.771 52.555 1.00 60.57 A C原子1938 CB GLU A 279 8.051 34.129 54.045 1.00 62.28 A C原子1939 CG GLU A 279 8.494 35.584 54.293 1.00 65.13 A C原子1940 CD GLU A 279 7.628 36.622 53.548 1.00 67.00 A C原子1941 OE1 GLU A 279 8.186 37.605 53.001 1.00 65.40 A O原子1942 OE2 GLU A 279 6.386 36.455 53.508 1.00 68.90 A O原子1943 C GLU A 279 9.243 33.971 51.819 1.00 59.65 A C原子1944 O GLU A 279 9.531 35.076 51.347 1.00 59.83 A O原子1945 N GLN A 280 10.053 32.906 51.731 1.00 57.19 A N原子1946 CA GLN A 280 11.344 32.962 51.031 1.00 52.60 A C原子1947 CB GLN A 280 12.228 31.745 51.353 1.00 50.20 A C原子1948 CG GLN A 280 13.209 31.992 52.500 1.00 44.34 A C原子1949 CD GLN A 280 13.961 30.749 52.950 1.00 43.42 A C原子1950 OE1 GLN A 280 13.525 29.614 57.726 1.00 41.23 A O原子1951 NE2 GLN A 280 15.097 30.962 53.616 1.00 43.42 A N原子1952 C GLN A 280 11.149 33.116 49.526 1.00 52.70 A C
原子1953 O GLN A 280 11.942 33.783 48.870 1.00 53.18 A O原子1954 N ILE A 281 10.090 32.512 48.988 1.00 52.81 A N原子1955 CA ILE A 281 9.769 32.626 47.564 1.00 52.86 A C原子1956 CB ILE A 281 8.693 31.593 47.124 1.00 51.64 A C原子1957 CG2 ILE A 281 8.363 31.769 45.637 1.00 49.72 A C原子1958 CG1 ILE A 281 9.180 30.164 47.418 1.00 51.24 A C原子1959 CD1 ILE A 281 8.203 29.066 47.052 1.00 47.72 A C原子1960 C ILE A 281 9.217 34.028 47.340 1.00 54.71 A C原子1961 O ILE A 281 9.445 34.641 46.299 1.00 54.52 A O原子1962 N ARG A 282 8.503 34.523 48.348 1.00 57.89 A N原子1963 CA ARG A 282 7.907 35.858 48.339 1.00 61.57 A C原子1964 CB ARG A 282 7.115 36.065 49.649 1.00 65.77 A C原子1965 CG ARG A 282 6.304 37.382 49.785 1.00 70.81 A C原子1966 CD ARG A 282 4.780 37.122 49.924 1.00 74.24 A C原子1967 NE ARG A 282 4.174 36.704 48.654 1.00 77.26 A N原子1968 CZ ARG A 282 3.795 35.461 48.363 1.00 78.31 A C原子1969 NH1 ARG A 282 3.942 34.490 49.261 1.00 77.99 A N原子1970 NH2 ARG A 282 3.327 35.182 47.147 1.00 79.39 A N原子1971 C ARG A 282 9.030 36.898 48.223 1.00 62.70 A C原子1972 O ARG A 282 8.943 37.837 47.415 1.00 61.98 A O原子1973 N GLU A 283 10.077 36.707 49.035 1.00 63.46 A N原子1974 CA GLU A 283 11.253 37.586 49.079 1.00 63.98 A C原子1975 CB GLU A 283 12.276 37.027 50.069 1.00 65.14 A C原子1976 CG GLU A 283 11.714 36.699 51.434 1.00 69.02 A C原子1977 CD GLU A 283 11.867 37.845 52.414 1.00 72.19 A C原子1978 OE1 GLU A 283 11.893 37.576 53.641 1.00 72.91 A O原子1979 OE2 GLU A 283 11.976 39.010 51.955 1.00 73.68 A O原子1980 C GLU A 283 11.908 37.678 47.699 1.00 64.28 A C
原子1981 O GLU A 283 12.278 38.764 47.238 1.00 64.39 A O原子1982 N MET A 284 12.076 36.517 47.067 1.00 64.56 A N原子1983 CA MET A 284 12.685 36.408 45.744 1.00 64.45 A C原子1984 CB MET A 284 13.048 34.960 45.446 1.00 63.90 A C原子1958 CG MET A 284 14.116 34.406 46.337 1.00 62.32 A C原子1968 SD MET A 284 14.526 32.763 45.814 1.00 61.63 A S原子1987 CE MET A 284 13.713 31.797 47.077 1.00 62.42 A C原子1988 C MET A 284 11.764 36.917 44.654 1.00 65.86 A C原子1989 O MET A 284 12.198 37.634 43.754 1.00 67.29 A O原子1990 N ASN A 285 10.509 36.917 44.687 1.00 66.58 A N原子1991 CA ASN A 285 9.545 36.941 43.701 1.00 67.61 A C原子1992 CB ASN A 285 9.253 35.866 42.658 1.00 69.13 A C原子1993 CG ASN A 285 8.518 36.423 41.447 1.00 69.68 A C原子1994 OD1 ASN A 285 8.879 36.150 40.296 1.00 68.82 A O原子1995 ND2 ASN A 285 7.491 37.228 41.704 1.00 71.06 A N ATOM，1996 C ASN A 285 8.264 37.357 44.397 1.00 68.27 A C原子1997 O ASN A 285 7.546 36.528 44.962 1.00 67.84 A O原子1998 N PRO A 286 7.969 38.664 44.372 1.00 69.70 A N原子1999 CD PRO A 286 8.764 39.688 43.669 1.00 70.02 A C原子2000 CA PRO A 286 6.778 39.255 44.989 1.00 71.26 A C原子2001 CB PRO A 286 6.908 40.740 44.617 1.00 71.42 A C原子2002 CG PRO A 286 7.723 40.722 43.334 1.00 70.10 A C原子2003 C PRO A 286 5.446 38.648 44.513 1.00 71.88 A C原子2004 O PRO A 286 4.474 38.564 45.269 1.00 71.95 A O原子2005 N ASN A 287 5.414 38.185 43.273 1.00 71.98 A N原子2006 CA ASN A 287 4.194 37.608 42.756 1.00 73.66 A C原子2007 CB ASN A 287 3.628 38.509 41.670 1.00 74.28 A C原子2008 CG ASN A 2874.680 38.947 40.688 1.00 75.29 A C
原子2009 OD1 ASN A 287 5.302 39.998 40.860 1.00 75.80 A O原子2010 ND2 ASN A 287 4.910 38.131 39.663 1.00 75.24 A N原子2011 C ASN A 287 4.366 36.194 42.226 1.00 74.95 A C原子2012 O ASN A 287 4.551 35.995 41.025 1.00 73.70 A O原子2013 N TYR A 288 4.321 35.214 43.131 1.00 77.12 A N原子2014 CA TYR A 288 4.437 33.817 42.728 1.00 78.50 A C原子2015 CB TYR A 288 5.728 33.176 43.243 1.00 76.75 A C原子2016 CG TYR A 288 6.290 32.211 42.229 1.00 75.51 A C原子2017 CD1 TYRA 288 6.578 32.638 40.931 1.00 75.77 A C原子2018 CE1 TYR A 288 7.010 31.746 39.955 1.00 73.80 A C原子2019 CD2 TYR A 288 6.459 30.865 42.529 1.00 74.29 A C原子2020 CE2 TYR A 288 6.891 29.965 41.561 1.00 72.41 A C原子2021 CZ TYR A 288 7.163 30.411 40.278 1.00 72.58 A C原子2022 OH TYR A 288 7.581 29.525 39.312 1.00 72.10 A O原子2023 C TYR A 288 3.219 32.977 43.120 1.00 80.65 A C原子2024 O TYR A 288 2.452 33.325 44.027 1.00 81.49 A O原子2025 N THR A 289 3.033 31.875 42.408 1.00 82.25 A N原子2026 CA THR A 289 1.900 31.006 42.663 1.00 84.05 A C原子2027 CB THR A 289 0.654 31.542 41.945 1.00 85.30 A C原子2028 OG1 THR A 289 1.064 32.369 40.844 1.00 84.50 A O原子2029 CG2 THR A 289-0.207 32.355 42.913 1.00 85.63 A C原子2030 C THR A 289 2.163 29.550 42.274 1.00 85.09 A C原子2031 O THR A 289 1.606 29.024 41.298 1.00 84.94 A O原子2032 N GLU A 290 3.021 28.916 43.065 1.00 86.20 A N原子2033 CA GLU A 290 3.403 27.521 42.889 1.00 87.69 A C原子2034 CB GLU A 290 4.891 27.417 42.546 1.00 87.88 A C原子2035 CG GLU A 290 5.544 26.100 42.971 1.00 87.42 A C原子2036 CD GLU A 290 6.685 26.306 43.954 1.00 87.10 A C
原子2037 OE1 GLU A 290 7.330 37443.911 1.00 87.45 A O原子2038 OE2 GLU A 290 6.942 25.399 44.772 1.00 86.98 A O原子2039 C GLU A 290 3.164 26.860 44.230 1.00 89.30 A C原子2040 O GLU A 290 2.168 26.171 44.432 1.00 90.44 A O原子2041 N PHE A 291 4.101 27.084 45.144 1.00 90.96 A N原子2042 CA PHE A 291 4.033 26.557 46.502 1.00 92.39 A C原子2043 CB PHE A 291 2.932 27.304 47.278 1.00 93.84 A C原子2044 CG PHE A 291 3.105 28.816 47.263 1.00 95.33 A C原子2045 CD1 PHE A 291 2.664 29.573 46.174 1.00 95.95 A C原子2046 CD2 PHE A 291 3.756 29.471 48.309 1.00 95.47 A C原子2047 CE1 PHE A 291 2.874 30.952 46.120 1.00 96.04 A C原子2048 CE2 PHE A 291 3.971 30.854 48.266 1.00 95.86 A C原子2049 CZ PHE A 291 3.529 31.594 47.167 1.00 95.84 A C原子2050 C PHE A 291 3.923 25.025 46.651 1.00 92.34 A C原子2051 O PHE A 291 3.186 24.523 47.500 1.00 91.41 A O原子2052 N LYS A 292 4.678 24.292 45.829 1.00 93.11 A N原子2053 CA LYS A 292 4.697 22.827 45.895 1.00 94.07 A C原子2054 CB LYS A 292 4.043 22.183 44.667 1.00 93.74 A C原子2055 CG LYS A 292 2.512 22.195 44.708 1.00 94.62 A C原子2056 CD LYS A 292 1.931 21.395 45.890 1.00 93.86 A C原子2057 CE LYS A 292 1.963 19.885 45.638 1.00 93.49 A C原子2058 NZ LYS A 292 1.251 19.097 46.695 1.00 92.59 A N原子2059 C LYS A 292 6.095 22.247 46.138 1.00 94.39 A C原子2060 O LYS A 292 6.958 22.918 46.715 1.00 95.11 A O原子2061 N PHE A 293 6.325 21.019 45.670 1.00 93.89 A N原子2062 CA PHE A 293 7.600 20.315 45.886 1.00 93.12 A C原子2063 CB PHE A 293 8.808 21.208 45.536 1.00 91.37 A C原子2064 CG PHE A 293 10.052 20.441 45.114 1.00 88.10 A C
原子2065 CD1 PHE A 293 10.728 20.789 43.947 1.00 85.71 A C原子2066 CD2 PHE A 293 10.569 19.411 45.900 1.00 87.28 A C原子2067 CE1 PHE A 293 11.886 20.124 43.566 1.00 84.42 A C原子2068 CE2 PHE A 293 11.733 18.738 45.524 1.00 85.93 A C原子2069 CZ PHE A 293 12.393 19.102 44.360 1.0084.27 A C原子2070 C PHE A 293 7.590 19.964 47.380 1.00 93.58 A C原子2071 O PHE A 293 7.380 20.832 48.232 1.00 93.31 A O原子2072 N PRO A 294 7.772 18.677 47.715 1.00 94.65 A N原子2073 CD PRO A 294 8.138 17.567 46.813 1.00 94.70 A C原子2074 CA PRO A 294 7.766 18.250 49.124 1.00 95.40 A C原子2075 CB PRO A 294 8.122 16.757 49.032 1.00 95.87 A C原子2076 CG PRO A 294 8.915 16.656 47.725 1.00 95.35 A C原子2077 C PRO A 294 8.738 19.038 50.013 1.00 95.26 A C原子2078 O PRO A 294 9.561 19.799 49.507 1.00 96.69 A O原子2079 N GLN A 295 8.636 18.872 51.331 1.00 93.87 A N原子2080 CA GLN A 295 9.536 19.578 52.245 1.00 91.58 A C原子2081 CB GLN A 295 8.860 19.835 53.597 1.00 93.08 A C原子2082 CG GLN A 295 9.744 20.558 54.618 1.00 94.67 A C原子2083 CD GLN A 295 10.176 21.942 54.152 1.00 96.42 A C原子2084 OE1 GLN A 295 9.344 22.780 53.789 1.00 97.73 A O原子2085 NE2 GLN A 295 11.484 22.192 54.169 1.00 97.29 A N原子2086 C GLN A 295 10.875 18.855 52.463 1.00 89.73 A C原子2087 O GLN A 295 11.025 18.064 53.412 1.00 90.32 A O原子2088 N ILE A 296 11.825 19.111 51.558 1.00 86.50 A N原子2089 CA ILE A 296 13.173 18.548 51.629 1.00 82.27 A C原子2090 CB ILE A 296 13.877 18.594 50.250 1.00 80.67 A C原子2091 CG2 ILE A 296 15.247 17.945 50.332 1.00 79.90 A C原子2092 CG1 ILE A 296 13.026 17.877 49.202 1.00 80.01 A C
原子2093 CD1 ILE A 296 12.703 16.432 49.541 1.00 80.62 A C原子2094 C ILE A 296 13.910 19.452 52.617 1.00 80.55 A C原子2095 O ILE A 296 13.809 20.680 52.538 1.00 78.56 A O原子2096 N LYS A 297 14.618 18.859 53.572 1.00 79.61 A N原子2097 CA LYS A 297 15.308 19.671 54.569 1.00 78.21 A C原子2098 CB LYS A 297 15.248 19.018 55.957 1.00 79.28 A C原子2099 CG LYS A 297 15.248 20.036 57.100 1.00 80.65 A C原子2100 CD LYS A 297 14.145 21.064 56.881 1.00 81.45 A C原子2101 CE LYS A 297 14.092 22.115 57.980 1.00 81.91 A C原子2102 NZ LYS A 297 13.001 23.103 57.710 1.00 80.82 A N原子2103 C LYS A 297 16.742 20.034 54.205 1.00 76.12 A C原子2104 O LYS A 297 17.401 19.342 53.416 1.00 75.82 A O原子2105 N ALA A 298 17.205 21.144 54.776 1.00 73.08 A N原子2106 CA ALA A 298 18.549 21.639 54.532 1.00 69.06 A C原子2107 CB ALA A 298 18.721 23.008 55.147 1.00 68.63 A C原子2108 C ALA A 298 19.606 20.703 55.068 1.00 66.97 A C原子2109 O ALA A 298 19.516 20.214 56.194 1.00 65.72 A O原子2110 N HIS A 299 20.594 20.421 54.236 1.00 65.83 A N原子2111 CA HIS A 299 21.687 19.571 54.661 1.00 65.16 A C原子2112 CB HIS A 299 22.358 18.917 53.442 1.00 66.44 A C原子2113 CG HIS A 299 22.755 17.489 53.672 1.00 68.36 A C原子2114 CD2 HIS A 299 22.445 16.356 52.998 1.00 68.94 A C原子2115 ND1 HIS A 299 23.530 17.097 54.745 1.00 68.97 A N原子2116 CE1 HIS A 299 23.675 15.784 54.723 1.00 69.68 A C原子2117 NE2 HIS A 299 23.027 15.309 53.674 1.00 69.24 A N原子2118 C HIS A 299 22.671 20.486 55.417 1.00 62.98 A C原子2119 O HIS A 299 23.095 21.519 54.887 1.00 63.93 A O原子2120 N PRO A 300 23.003 20.147 56.679 1.00 59.13 A N
原子2121 CD PRO A 300 22.665 18.881 57.338 1.00 57.19 A C原子2122 CA PRO A 300 23.928 20.930 57.514 1.00 56.39 A C原子2123 CB PRO A 300 24.339 19.936 58.609 1.00 56.10 A C原子2124 CG PRO A 300 23.948 18.578 58.043 1.00 56.40 A C原子2125 C PRO A 300 25.136 21.465 56.749 1.00 53.76 A C原子2126 O PRO A 300 25.824 20.717 56.057 1.00 51.52 A O原子2127 N TRP A 301 25.387 22.766 56.877 1.00 53.44 A N原子2128 CA TRP A 301 26.498 23.399 56.167 1.00 53.15 A C原子2129 CB TRP A 301 26.569 24.892 56.488 1.00 54.73 A C原子2130 CG TRP A 301 25.691 25.757 55.617 1.00 57.29 A C原子2131 CD2 TRP A 301 25.791 25.931 54.194 1.00 57.65 A C原子2132 CE2 TRP A 301 24.757 26.809 53.804 1.00 58.15 A C原子2133 CE3 TRP A 301 26.647 25.425 53.212 1.00 58.15 A C原子2134 CD1 TRP A 301 24.632 26.520 56.020 1.00 59.38 A C原子2135 NE1 TRP A 301 24.063 27.155 54.935 1.00 59.83 A N原子2136 CZ2 TRP A 301 24.560 27.188 52.472 1.00 58.11 A C原子2137 CZ3 TRP A 301 26.447 25.802 51.886 1.00 59.05 A C原子2138 CH2 TRP A 301 25.413 26.674 51.531 1.00 59.26 A C原子2139 C TRP A 301 27.848 22.752 56.431 1.00 52.73 A C原子2140 O TRP A 301 28.720 22.735 55.567 1.00 52.39 A O原子2141 N THR A 302 28.019 22.225 57.635 1.00 53.22 A N原子2142 CA THR A 302 29.267 21.586 58.022 1.00 53.06 A C原子2143 CB THR A 302 29.344 21.422 59.553 1.00 52.33 A C原子2144 OG1 THR A 302 28.278 20.566 59.989 1.00 53.54 A O原子2145 CG2 THR A 302 29.199 22.784 60.241 1.00 51.05 A C原子2146 C THR A 302 29.422 20.220 57.360 1.00 54.26 A C原子2147 O THR A 302 30.537 19.712 57.262 1.00 55.39 A O原子2148 N LYS A 303 28.303 19.648 56.896 1.00 54.83 A N
原子2149 CA LYS A 303 28.264 18.326 56.232 1.00 53.18 A C原子2150 CB LYS A 303 26.937 17.598 56.526 1.00 55.86 A C原子2151 CG LYS A 303 26.845 16.951 57.900 1.00 58.61 A C原子2152 CD LYS A 303 27.815 15.791 58.006 1.00 63.03 A C原子2153 CE LYS A 303 27.575 14.971 59.264 1.00 64.64 A C原子2154 NZ LYS A 303 28.453 13.764 59.289 1.00 65.98 A N原子2155 C LYS A 303 28.469 18.402 54.715 1.00 50.85 A C原子2156 O LYS A 303 28.839 17.405 54.080 1.00 49.92 A O原子2157 N VAL A 304 28.173 19.565 54.134 1.00 47.30 A N原子2158 CA VAL A 304 28.351 19.763 52.702 1.00 45.63 A C原子2159 CB VAL A 304 27.613 21.017 52.211 1.00 44.60 A C原子2160 CG1 VAL A 304 27.938 22.179 53.085 1.00 46.51 A C原子2161 CG2 VAL A 304 27.978 21.314 50.775 1.00 43.54 A C原子2162 C VAL A 304 29.837 19.846 52.350 1.00 44.52 A C原子2163 O VAL A 304 30.284 19.281 51.356 1.00 44.39 A O原子2164 N PHE A 305 30.610 20.517 53.192 1.00 44.21 A N原子2165 CA PHE A 305 32.042 20.645 52.956 1.00 44.80 A C原子2166 CB PHE A 305 32.530 22.006 53.438 1.00 42.07 A C原子2167 CG PHE A 305 31.864 23.156 52.744 1.00 39.78 A C原子2168 CD1 PHE A 305 32.069 23.372 51.375 1.00 37.45 A C原子2169 CD2 PHE A 305 31.012 24.013 53.446 1.00 36.45 A C原子2170 CE1 PHE A 305 31.441 24.414 50.721 1.00 33.84 A C原子2171 CE2 PHE A 305 30.380 25.059 52.796 1.00 34.18 A C原子2172 CZ PHE A 305 30.597 25.256 51.429 1.00 34.04 A C原子2173 C PHE A 305 32.872 19.536 53.599 1.00 47.33 A C原子2174 O PHE A 305 32.428 18.866 54.536 1.00 48.48 A O原子2175 N ARG A 306 34.080 19.339 53.081 1.00 48.81 A N原子2176 CA ARG A 306 34.970 18.322 53.609 1.00 48.89 A C
原子2177 CB ARG A 306 36.164 18.142 52.673 1.00 49.99 A C原子2178 CG ARG A 306 37.164 19.292 52.666 1.00 51.90 A C原子2179 CD ARG A 306 38.370 18.936 51.770 1.00 55.36 A C原子2180 NE ARG A 306 39.381 19.995 51.659 1.00 55.23 A N原子2181 CZ ARG A 306 40.363 20.198 52.533 1.00 54.45 A C原子2182 NH1 ARG A 306 40.467 19.423 53.601 1.00 54.45 A N原子2183 NH2 ARG A 306 41.274 21.139 52.309 1.00 54.15 A N原子2184 C ARG A 306 35.475 18.714 54.992 1.00 49.49 A C原子2185 O ARG A 306 35.517 19.888 55.328 1.00 48.86 A O原子2186 N PRO A 307 35.776 17.728 55.850 1.00 51.03 A N原子2187 CD PRO A 307 35.660 16.264 55.730 1.00 51.81 A C原子2188 CA PRO A 307 36.279 18.113 57.174 1.00 52.52.33 A C原子2189 CB PRO A 307 36.281 16.786 57.940 1.00 52.40 A C原子2190 CG PRO A 307 36.581 15.784 56.851 1.00 53.45 A C原子2191 C PRO A 307 37.698 18.629 56.932 1.00 53.22 A C原子2192 O PRO A 307 38.417 18.109 56.064 1.00 54.90 A O原子2193 N ARG A 308 38.084 19.656 57.682 1.00 53.43 A N原子2194 CA ARG A 308 39.395 20.296 57.556 1.00 53.93 A C原子2195 CB ARG A 308 40.343 19.516 56.628 1.00 56.89 A C原子2196 CG ARG A 308 41.721 19.150 57.240 1.00 62.21 A C原子2197 CD ARG A 308 41.670 17.934 58.189 1.00 66.15 A C原子2198 NE ARG A 308 41.220 18.277 59.545 1.00 69.51 A N原子2199 CZ ARG A 308 40.164 17.742 60.165 1.00 70.12 A C原子2200 NH1 ARG A 308 39.410 16.821 59.568 1.00 70.90 A N原子2201 NH2 ARG A 308 39.874 18.109 61.404 1.00 70.42 A N原子2202 C ARG A 308 39.110 21.667 56.971 1.00 51.42 A C原子2203 O ARG A 308 40.017 22.479 56.808 1.00 53.93 A O原子2204 N THR A 309 37.835 21.886 56.636 1.00 48.02 A N
原子2205 CA THR A 309 37.319 23.147 56.084 1.00 43.15 A C原子2206 CB THR A 309 35.958 22.905 55.335 1.00 42.42 A C原子2207 OG1 THR A 309 36.166 22.012 54.235 1.00 41.09 A O原子2208 CG2 THR A 309 35.368 24.206 54.800 1.00 40.07 A C原子2209 C THR A 309 37.123 24.167 57.235 1.00 41.47 A C原子2210 O THR A 309 36.339 23.944 58.168 1.00 41.71 A O原子2211 N PRO A 310 37.851 25.295 57.193 1.00 40.09 A N原子2212 CD PRO A 310 38.818 25.687 56.149 1.00 39.28 A C原子2213 CA PRO A 310 37.750 26.330 58.233 1.00 40.15 A C原子2214 CB PRO A 310 38.492 27.507 57.599 1.00 38.80 A C原子2215 CG PRO A 310 39.576 26.823 56.810 1.00 38.52 A C原子2216 C PRO A 310 36.314 26.710 58.631 1.00 40.82 A C原子2217 O PRO A 310 35.477 26.982 57.767 1.00 41.57 A O原子2218 N PRO A 311 36.003 26.704 59.945 1.00 41.00 A N原子2219 CD PRO A 311 36.837 26.264 61.081 1.00 41.74 A C原子2220 CA PRO A 311 34.653 27.060 60.394 1.00 38.86 A C原子2221 CB PRO A 311 34.800 27.084 61.920 1.00 38.92 A C原子2222 CG PRO A 311 35.801 26.002 62.168 1.00 40.08 A C原子2223 C PRO A 311 34.202 28.421 59.846 1.00 38.07 A C原子2224 O PRO A 311 33.036 28.593 59.499 1.00 38.17 A O原子2225 N GLU A 312 35.127 29.376 59.736 1.00 37.33 A N原子2226 CA GLU A 312 34.780 30.710 59.250 1.00 37.51 A C原子2227 CB GLU A 312 35.856 31.753 59.604 1.00 41.12 A C原子2228 CG GLU A 312 36.591 31.536 60.940 1.00 44.01 A C原子2229 CD GLU A 312 37.738 30.521 60.817 1.00 46.77 A C原子2230 OE1 GLU A 312 38.555 30.645 59.864 1.00 46.40 A O原子2231 OE2 GLU A 312 37.821 29.602 61.667 1.00 48.12 A O原子2232 C GLU A 312 34.470 30.746 57.753 1.00 36.53 A C
原子2233 O GLU A 312 33.817 31.683 57.284 1.00 38.60 A O原子2234 N ALA A 313 34.943 29.743 57.007 1.00 32.61 A N原子2235 CA ALA A 313 34.672 29.643 55.568 1.00 30.50 A C原子2236 CB ALA A 313 35.640 28.678 54.919 1.00 26.90 A C原子2237 C ALA A 313 33.232 29.138 55.389 1.00 32.00 A C原子2238 O ALA A 313 32.497 29.592 54.512 1.00 31.09 A O原子2239 N ILE A 314 32.852 28.168 56.219 1.00 30.90 A N原子2240 CA ILE A 314 31.514 27.595 56.195 1.00 31.31 A C原子2241 CB ILE A 314 31.473 26.325 57.069 1.00 29.56 A C原子2242 CG2 ILE A 314 30.089 25.798 57.224 1.00 28.99 A C原子2243 CG1 ILE A 314 32.397 25.270 56.499 1.00 29.23 A C原子2244 CD1 ILE A 314 32.618 24.139 57.469 1.00 33.00 A C原子2245 C ILE A 314 30.519 28.652 56.713 1.00 32.69 A C原子2246 0 ILE A 314 29.422 28.808 56.164 1.00 34.20 A O原子2247 N ALA A 315 30.914 29.401 57.746 1.00 31.67 A N原子2248 CA ALA A 315 30.046 30.444 58.301 1.00 29.37 A C原子2249 CB ALA A 315 30.600 30.959 59.604 1.00 31.47 A C原子2250 C ALA A 315 29.864 31.589 57.316 1.00 28.53 A C原子2251 O ALA A 315 28.759 32.104 57.160 1.00 27.48 A O原子2252 N LEU A 316 30.945 31.994 56.648 1.00 27.86 A N原子2253 CA LEU A 316 30.840 33.060 55.658 1.00 26.99 A C原子2254 CB LEU A 316 32.218 33.445 55.093 1.00 22.62 A C原子2255 CG LEU A 316 32.146 34.208 53.746 1.00 21.40 A C原子2256 CD1 LEU A 316 31.342 35.491 53.840 1.00 20.39 A C原子2257 CD2 LEU A 316 33.535 34.512 53.239 1.00 22.56 A C原子2258 C LEU A 316 29.932 32.591 54.515 1.00 27.58 A C原子2259 O LEU A 316 29.112 33.330 53.993 1.00 27.33 A O原子2260 N CYS A 317 30.086 31.342 54.130 1.00 30.89 A N
原子2261 CA CYS A 317 29.314 30.819 53.036 1.00 32.18 A C原子2262 CB CYS A 317 29.785 29.420 52.698 1.00 35.80 A C原子2263 SG CYS A 317 29.183 28.888 51.123 1.00 40.78 A S原子2264 C CYS A 317 27.829 30.819 53.329 1.00 33.09 A C原子2265 O CYS A 317 27.041 31.117 52.442 1.00 33.68 A O原子2266 N SER A 318 27.441 30.495 54.564 1.00 32.85 A N原子2267 CA SER A 318 26.021 30.475 54.912 1.00 32.51 A C原子2268 CB SER A 318 25.803 29.909 56.323 1.00 30.97 A C原子2269 OG SER A 318 26.537 30.621 57.292 1.00 31.88 A O原子2270 C SER A 318 25.389 31.862 54.776 1.00 33.51 A C原子2271 O SER A 318 24.193 31.996 54.507 1.00 36.08 A O原子2272 N ARG A 319 26.216 32.891 54.893 1.00 32.72 A N原子2273 CA ARG A 319 25.760 34.266 54.802 1.00 32.06 A C原子2274 CB ARG A 319 26.649 35.164 55.679 1.00 35.37 A C原子2275 CG ARG A 319 26.606 34.855 57.186 1.00 41.25 A C原子2276 CD ARG A 319 25.471 35.594 57.895 1.00 46.70 A C原子2277 NE ARG A 319 24.191 35.283 57.259 1.00 54.82 A N原子2278 CZ ARG A 319 23.402 36.176 56.661 1.00 57.65 A C原子2279 NH1 ARG A 319 23.758 37.459 56.635 1.00 59.93 A N原子2280 NH2 ARG A 319 22.300 35.771 56.018 1.00 57.91 A N原子2281 C ARG A 319 25.719 34.794 53.361 1.00 30.32 A C原子2282 O ARG A 319 25.369 35.952 53.130 1.00 28.75 A O原子2283 N LEU A 320 26.067 33.946 52.390 1.00 30.34 A N原子2284 CA LEU A 320 26.063 34.334 50.965 1.00 27.78 A C原子2285 CB LEU A 320 27.434 34.123 50.344 1.00 28.29 A C原子2286 CG LEU A 320 28.616 34.851 50.978 1.00 29.36 A C原子2287 CD1 LEU A 320 29.913 34.343 50.341 1.00 29.51 A C原子2288 CD2 LEU A 320 28.467 36.357 50.801 1.00 29.87 A C
原子2289 C LEU A 320 25.048 33.528 50.155 1.00 28.32 A C原子2290 O LEU A 320 24.387 34.053 49.262 1.00 26.82 A O原子2291 N LEU A 321 24.958 32.237 50.458 1.00 28.84 A N原子2292 CA LEU A 321 24.031 31.336 49.782 1.00 29.38 A C原子2293 CB LEU A 321 24.672 29.951 49.610 1.00 27.04 A C原子2294 CG LEU A 321 25.955 30.000 48.764 1.00 25.10 A C原子2295 CD1 LEU A 321 26.509 28.596 48.566 1.00 22.83 A C原子2296 CD2 LEU A 321 25.656 30.665 47.421 1.00 23.61 A C原子2297 C LEU A 321 22.743 31.248 50.592 1.00 30.12 A C原子2298 O LEU A 321 22.475 30.260 51.269 1.00 30.60 A O原子2299 N GLU A 322 21.984 32.331 50.563 1.00 32.99 A N原子2300 CA GLU A 322 20.723 32.411 51.283 1.00 35.35 A C原子2301 CB GLU A 322 20.845 33.432 52.440 1.00 39.44 A C原子2302 CG GLU A 322 20.031 33.075 53.699 1.00 45.14 A C原子2303 CD GLU A 322 18.561 32.709 53.390 1.00 49.02 A C原子2304 OE1 GLU A 322 18.278 31.537 52.998 1.00 48.76 A O原子2305 OE2 GLU A 322 17.690 33.603 53.528 1.00 50.22 A O原子2306 C GLU A 322 19.679 32.868 50.246 1.00 35.18 A C原子2307 O GLU A 322 19.994 33.675 49.368 1.00 32.98 A O原子2308 N TYR A 323 18.460 32.322 50.318 1.00 36.47 A N原子2309 CA TYR A 323 17.376 32.680 49.386 1.00 35.07 A C原子2310 CB TYR A 323 16.122 31.833 49.632 1.00 35.73 A C原子2311 CG TYR A 323 16.268 30.370 49.288 1.00 36.48 A C原子2312 CD1 TYR A 323 16.316 29.950 47.968 1.00 36.94 A C原子2313 CE1 TYR A 323 16.403 28.612 47.649 1.00 35.30 A C原子2314 CD2 TYR A 323 16.314 29.407 50.281 1.00 35.92 A C原子2315 CE2 TYR A 323 16.395 28.073 49.972 1.00 35.74 A C原子2316 CZ TYR A 323 16.437 27.675 48.654 1.00 35.11 A C
原子2317 OH TYR A 323 16.480 26.332 48.343 1.00 35.85 A O原子2318 C TYR A 323 16.980 34.148 49.408 1.00 35.43 A C原子2319 O TYR A 323 16.855 34.765 48.360 1.00 35.68 A O原子2320 N THR A 324 16.730 34.695 50.595 1.00 36.52 A N原子2321 CA THR A 324 16.343 36.098 50.713 1.00 35.98 A C原子2322 CB THR A 324 15.968 36.447 52.183 1.00 37.86 A C原子2323 OG1 THR A 324 15.183 35.388 52.755 1.00 35.45 A O原子2324 CG2 THR A 324 15.171 37.761 52.233 1.00 37.80 A C原子2325 C THR A 324 17.529 36.949 50.262 1.00 35.55 A C原子2326 O THR A 324 18.558 36.976 50.912 1.00 37.14 A O原子2327 N PRO A 325 17.414 37.631 49.121 1.00 36.35 A N原子2328 CD PRO A 325 16.339 37.558 48.118 1.00 35.78 A C原子2329 CA PRO A 325 18.544 38.454 48.658 1.00 38.73 A C原子2330 CB PRO A 325 18.072 38.966 47.284 1.00 40.10 A C原子2331 CG PRO A 325 16.559 38.822 47.318 1.00 39.73 A C原子2332 C PRO A 325 19.039 39.588 49.583 1.00 40.75 A C原子2333 0 PRO A 325 20.194 40.058 49.464 1.00 39.35 A O原子2334 N THR A 326 18.169 40.010 50.502 1.00 41.77 A N原子2335 CA THR A 326 18.484 41.078 51.446 1.00 42.08 A C原子2336 CB THR A 326 17.240 41.936 51.812 1.00 43.80 A C原子2337 OG1 THR A 326 16.280 41.127 52.507 1.00 44.31 A O原子2338 CG2 THR A 326 16.593 42.546 50.554 1.00 43.61 A C原子2339 C THR A 326 19.049 40.507 52.730 1.00 43.10 A C原子2340 O THR A 326 19.348 41.262 53.657 1.00 45.68 A O原子2341 N ALA A 327 19.112 39.175 52.819 1.00 41.67AN原子2342 CA ALA A 327 19.685 38.492 53.991 1.00 41.21 A C原子2343 CB ALA A 327 18.935 37.210 54.290 1.00 42.03 A C原子2344 C ALA A 327 21.161 38.175 53.716 1.00 40.39 A C
原子2345 O ALA A 327 21.911 37.789 54.613 1.00 38.69 A O原子2346 N ARG A 328 21.551 38.300 52.449 1.00 39.41 A N原子2347 CA ARG A 328 22.925 38.050 52.036 1.00 37.97 A C原子2348 CB ARG A 328 23.011 37.737 50.537 1.00 34.85 A C原子2349 CG ARG A 328 22.158 36.607 50.067 1.00 31.64 A C原子2350 CD ARG A 328 22.138 36.598 48.566 1.00 31.39 A C原子2351 NE ARG A 328 21.061 35.748 48.087 1.00 32.71 A N原子2352 CZ ARG A 328 20.474 35.862 46.902 1.00 30.91 A C原子2353 NH1 ARG A 328 20.869 36.798 46.050 1.00 28.07 A N原子2354 NH2 ARG A 328 19.456 35.057 46.598 1.00 30.25 A N原子2355 C ARG A 328 23.743 39.309 52.306 1.00 38.90 A C原子2356 O ARG A 328 23.264 40.443 52.101 1.00 39.08 A O原子2357 N LEU A 329 25.002 39.085 52.682 1.00 38.98 A N原子2358 CA LEU A 329 25.938 40.159 52.963 1.00 36.91 A C原子2359 CB LEU A 329 27.291 39.611 53.404 1.00 34.76 A C原子2360 CG LEU A 329 27.285 38.696 54.607 1.00 34.37 A C原子2361 CD1 LEU A 329 28.643 38.028 54.736 1.00 36.96 A C原子2362 CD2 LEU A 329 26.941 39.499 55.844 1.00 36.75 AC原子2363 C LEU A 329 26.166 41.044 51.753 1.00 37.04 A C原子2364 O LEU A 329 25.768 40.747 50.607 1.00 35.16 A O原子2365 N THR A 330 26.771 42.178 52.049 1.00 36.05 A N原子2366 CA THR A 330 27.093 43.129 51.020 1.00 35.84 A C原子2367 CB THR A 330 26.866 44.576 51.510 1.00 36.88 A C原子2368 OG1 THR A 330 27.687 44.825 52.664 1.00 38.57 A O原子2369 CG2 THR A 330 25.385 44.780 51.877 1.00 34.49 A C原子2370 C THR A 330 28.565 42.861 50.723 1.00 33.23 A C原子2371 O THR A 330 29.264 42.217 51.512 1.00 29.88 A O原子2372 N PRO A 331 29.020 43.253 49.531 1.00 32.89 A N
原子2373 CD PRO A 331 28.314 43.865 48.393 1.00 31.30 A C原子2374 CA PRO A 331 30.417 43.016 49.215 1.00 31.44 A C原子2375 CB PRO A 331 30.590 43.835 47.938 1.00 32.91 A C原子2376 CG PRO A 331 29.259 43.582 47.243 1.00 30.03 A C原子2377 C PRO A 331 31.316 43.452 50.379 1.00 32.42 A C原子2378 O PRO A 331 32.119 42.655 50.887 1.00 33.23 A O原子2379 N LEU A 332 31.135 44.686 50.846 1.00 33.33 A N原子2380 CA LEU A 332 31.923 45.221 51.962 1.00 32.18 A C原子2381 CB LEU A 332 31.587 46.692 52.196 1.00 35.97 A C原子2382 CG LEU A 332 32.405 47.843 51.612 1.00 39.70 A C原子2383 CD1 LEU A 332 32.090 49.080 52.436 1.00 40.02 A C原子2384 CD2 LEU A 332 33.900 47.558 51.679 1.00 40.52 A C原子2385 C LEU A 332 31.764 44.490 53.291 1.00 29.85 A C原子2386 O LEU A 332 32.645 44.555 54.132 1.00 32.12 A O原子2387 N GLU A 333 30.610 43.884 53.533 1.00 32.44 A N原子2388 CA GLU A 333 30.382 43.172 54.796 1.00 33.33 A C原子2389 CB GLU A 333 28.876 42.979 55.049 1.00 36.12 A C原子2390 CG GLU A 333 28.176 44.253 55.506 1.00 38.27 A C原子2391 CD GLU A 333 26.654 44.229 55.368 1.00 41.80 A C原子2392 OE1 GLU A 333 26.007 45.113 55.992 1.00 42.66 A O原子2393 OE2 GLU A 333 26.111 43.367 54.626 1.00 40.17 A O原子2394 C GLU A 333 31.103 41.836 54.781 1.00 33.17 A C原子2395 O GLU A 333 31.571 41.340 55.817 1.00 33.94 A O原子2396 N ALA A 334 31.157 41.257 53.582 1.00 33.77 A N原子2397 CA ALA A 334 31.819 39.983 53.348 1.00 32.19 A C原子2398 CB ALA A 334 31.653 39.574 51.908 1.00 33.03 A C原子2399 C ALA A 334 33.295 40.178 53.693 1.00 31.70 A C原子2400 O ALA A 334 33.811 39.507 54.592 1.00 32.27 A O
原子2401 N CYS A 335 33.948 41.130 53.015 1.00 29.04 A N原子2402 CA CYS A 335 35.354 41.463 53.280 1.00 28.08 A C原子2403 CB CYS A 335 35.684 42.820 52.700 1.00 25.06 A C原子2404 SG CYS A 335 35.664 42.913 50.983 1.00 31.08 A S原子2405 C CYS A 335 35.632 41.588 54.780 1.00 29.42 A C原子2406 O CYS A 335 36.694 41.200 55.271 1.00 30.83 A O原子2407 N ALA A 336 34.694 42.228 55.470 1.00 30.07 A N原子2408 CA ALA A 336 34.775 42.469 56.899 1.00 32.45 A C原子2409 CB ALA A 336 33.708 43.477 57.306 1.00 33.21 A C原子2410 C ALA A 336 34.620 41.184 57.698 1.00 33.44 A C原子2411 O ALA A 336 34.901 41.162 58.905 1.00 32.85 A O原子2412 N HIS A 337 34.175 40.124 57.021 1.00 32.02 A N原子2413 CA HIS A 337 33.986 38.832 57.658 1.00 30.44 A C原子2414 CB HIS A 337 33.390 37.807 56.673 1.00 29.63 A C原子2415 CG HIS A 337 32.956 36.526 57.323 1.00 27.00 A C原子2416 CD2 HIS A 337 31.733 36.110 57.736 1.00 29.14 A C原子2417 ND1 HIS A 337 33.837 35.523 57.674 1.00 28.86 A N原子2418 CE1 HIS A 337 33.177 34.549 58.280 1.00 28.43 A C原子2419 NE2 HIS A 337 31.898 34.881 58.330 1.00 29.35 A N原子2420 C HIS A 337 35.306 38.326 58.229 1.00 30.54 A C原子2421 O HIS A 337 36.385 38.615 57.704 1.00 29.81 A O原子2422 N SER A 338 35.209 37.565 59.310 1.00 30.75 A N原子2423 CA SER A 338 36.394 37.048 59.969 1.00 33.89 A C原子2424 CB SER A 338 36.088 36.545 61.384 1.00 32.18 A C原子2425 OG SER A 338 35.068 35.569 61.378 1.00 36.74 A O原子2426 C SER A 338 37.100 35.982 59.167 1.00 35.32 A C原子2427 O SER A 338 38.199 35.564 59.532 1.00 38.56 A O原子2428 N PHE A 339 36.469 35.494 58.106 1.00 33.93 A N
原子2429 CA PHE A 339 37.154 34.509 57.289 1.00 32.49 A C原子2430 CB PHE A 339 36.266 34.071 56.130 1.00 29.12 A C原子2431 CG PHE A 339 36.958 33.172 55.162 1.00 28.40 A C原子2432 CD1 PHE A 339 36.917 33.438 53.798 1.00 25.87 A C原子2433 CD2 PHE A 339 37.649 32.045 55.617 1.00 28.57 A C原子2434 CE1 PHE A 339 37.549 32.589 52.894 1.00 27.62 A C原子2435 CE2 PHE A 339 38.290 31.181 54.721 1.00 28.61 A C原子2436 CZ PHE A 339 38.236 31.457 53.357 1.00 27.87 A C原子2437 C PHE A 339 38.459 35.177 56.785 1.00 31.43 A C原子2438 O PHE A 339 39.529 34.575 56.799 1.00 32.88 A O原子2439 N PHE A 340 38.369 36.467 56.478 1.00 31.90 A N原子2440 CA PHE A 340 39.497 37.248 55.994 1.00 32.43 A C原子2441 CB PHE A 340 38.979 38.337 55.075 1.00 32.03 A C原子2442 CG PHE A 340 38.095 37.817 53.993 1.00 35.36 A C原子2443 CD1 PHE A 340 38.598 36.938 53.040 1.00 35.28 A C原子2444 CD2 PHE A 340 36.758 38.188 53.924 1.00 34.74 A C原子2445 CE1 PHE A 340 37.775 36.437 52.027 1.00 35.62 A C原子2446 CE2 PHE A 340 35.925 37.691 52.914 1.00 35.63 A C原子2447 CZ PHE A 340 36.432 36.816 5 1.967 1.0033.48 A C原子2448 C PHE A 340 40.406 37.877 57.055 1.00 34.61 A C原子2449 O PHE A 340 41.306 38.641 56.700 1.00 35.72 A O原子2450 N ASP A 341 40.207 37.567 58.339 1.00 35.33 A N原子2451 CA ASP A 341 41.059 38.152 59.391 1.00 35.61 A C原子2452 CB ASP A 341 40.687 37.632 60.784 1.00 36.67 A C原子2453 CG ASP A 341 39.411 38.245 61.315 1.00 38.76 A C原子2454 OD1 ASP A 341 39.001 39.318 60.814 1.00 40.77 A O原子2455 OD2 ASP A 341 38.816 37.644 62.237 1.00 39.86 A O原子2456 C ASP A 341 42.543 37.907 59.168 1.00 34.98 A C
原子2457 O ASP A 341 43.364 38.794 59.417 1.00 36.99 A O原子2458 N GLU A 342 42.895 36.699 58.730 1.00 34.36 A N原子2459 CA GLU A 342 44.300 36.389 58.502 1.00 34.14 A C原子2460 CB GLU A 342 44.510 34.944 58.026 1.00 36.25 A C原子2461 CG GLU A 342 45.980 34.645 57.716 1.00 35.88 A C原子2462 CD GLU A 342 46.222 33.239 57.219 1.00 38.38 A C原子2463 OE1 GLU A 342 45.333 32.678 56.542 1.00 38.14 A O原子2464 OE2 GLU A 342 47.314 32.698 57.503 1.00 39.48 A O原子2465 C GLU A 342 44.985 37.354 57.540 1.00 32.97 A C原子2466 O GLU A 342 46.184 37.585 57.677 1.00 32.96 A O原子2467 N LEU A 343 44.236 37.922 56.587 1.00 31.99 A N原子2468 CA LEU A 343 44.806 38.866 55.607 1.00 31.42 A C原子2469 CB LEU A 343 43.844 39.131 54.449 1.00 30.92 A C原子2470 CG LEU A 343 43.539 38.079 53.383 1.00 27.15 A C原子2471 CD1 LEU A 343 43.101 36.803 54.039 1.00 28.27 A C原子2472 CD2 LEU A 343 42.451 38.595 52.468 1.00 21.59 A C原子2473 C LEU A 343 45.150 40.197 56.243 1.00 31.51 A C原子2474 O LEU A 343 45.965 40.949 55.715 1.00 31.66 A O原子2475 N ARG A 344 44.480 40.497 57.350 1.00 33.95 A N原子2476 CA ARG A 344 44.709 41.733 58.085 1.00 35.66 A C原子2477 CB ARG A 344 43.390 42.241 58.649 1.00 30.95 A C原子2478 CG ARG A 344 42.498 42.793 57.581 1.00 26.72 A C原子2479 CD ARG A 344 41.166 43.229 58.144 1.00 27.97 A C原子2480 NE ARG A 344 40.322 42.105 58.534 1.00 25.79 A N原子2481 CZ ARG A 344 39.321 41.653 57.787 1.00 27.16 A C原子2482 NH1 ARG A 344 39.049 42.242 56.625 1.00 25.96 A N原子2483 NH2 ARG A 344 38.647 40.575 58.164 1.00 29.04 A N原子2484 C ARG A 344 45.784 41.596 59.179 1.00 39.42 A C
原子2485 O ARG A 344 46.086 42.555 59.892 1.00 40.56 A O原子2486 N ASP A 345 46.320 40.384 59.322 1.00 42.31 A N原子2487 CA ASP A 345 47.389 40.087 60.279 1.0043.57 A C原子2488 CB ASP A 345 47.656 38.573 60.320 1.0046.53 A C原子2489 CG ASP A 345 48.526 38.144 61.508 1.0048.58 A C原子2490 OD1 ASP A 345 49.669 38.642 61.642 1.00 50.52 A O原子2491 OD2 ASP A 345 48.063 37.282 62.293 1.00 48.36 A O原子2492 C ASP A 345 48.603 40.814 59.700 1.00 43.04 A C原子2493 O ASP A 345 48.872 40.718 58.508 1.00 39.51 A O原子2494 N PRO A 346 49.373 41.521 60.546 1.00 43.85 A N原子2495 CD PRO A 346 49.255 41.606 62.013 1.00 42.53 A C原子2496 CA PRO A 346 50.550 42.264 60.064 1.00 43.73 A C原子2497 CB PRO A 346 51.048 42.989 61.323 1.00 43.51 A C原子2498 CG PRO A 346 49.854 42.956 62.270 1.00 44.13 A C原子2499 C PRO A 346 51.676 41.441 59.423 1.00 44.71 A C原子2500 O PRO A 346 52.479 41.979 58.653 1.00 42.18 A O原子2501 N ASN A 347 51.734 40.150 59.748 1.00 45.80 A N原子2502 CA ASN A 347 52.780 39.274 59.226 1.00 48.40 A C原子2503 CB ASN A 347 53.489 38.548 60.392 1.00 50.52 A C原子2504 CG ASN A 347 53.829 39.481 61.575 1.00 51.68 A C原子2505 OD1 ASN A 347 53.106 39.510 62.583 1.00 52.97 A O原子2506 ND2 ASN A 347 54.943 40.219 61.465 1.00 50.64 A N原子2507 C ASN A 347 52.212 38.227 58.269 1.00 49.43 A C原子2508 O ASN A 347 52.649 37.078 58.294 1.00 51.30 A O原子2509 N VAL A 348 51.284 38.626 57.397 1.00 49.86 A N原子2510 CA VAL A 348 50.646 37.687 56.465 1.00 49.86 A C原子2511 CB VAL A 348 49.626 38.381 55.516 1.00 50.32 A C原子2512 CG1 VAL A 348 48.619 37.356 54.995 1.00 50.90 A C
原子2513 CG2 VAL A 348 48.926 39.542 56.193 1.00 51.72 A C原子2514 C VAL A 348 51.601 36.891 55.573 1.00 50.39 A C原子2515 O VAL A 348 51.924 35.726 55.850 1.00 52.96 A O原子2516 N LYS A 349 51.988 37.508 54.462 1.00 48.93 A N原子2517 CA LYS A 349 52.882 36.888 53.496 1.00 48.04 A C原子2518 CB LYS A 349 54.174 36.458 54.174 1.00 48.29 A C原子2519 CG LYS A 349 55.054 37.623 54.626 1.00 51.32 A C原子2520 CD LYS A 349 55.759 38.308 53.455 1.00 51.87 A C原子2521 CE LYS A 349 56.898 39.207 53.940 1.00 52.70 A C原子2522 NZ LYS A 349 57.699 39.755 52.802 1.00 55.92 A N原子2523 C LYS A 349 52.310 35.726 52.683 1.00 47.81 A C原子2524 O LYS A 349 51.711 34.792 53.217 1.00 48.27 A O原子2525 N LEU A 350 52.498 35.806 51.372 1.00 47.80 A N原子2526 CA LEU A 350 52.045 34.764 50.470 1.00 47.07 A C原子2527 CB LEU A 350 52.152 35.227 49.019 1.00 45.84 A C原子2528 CG LEU A 350 51.388 36.459 48.554 1.00 42.81 A C原子2529 CD1 LEU A 350 51.513 36.571 47.034 1.00 45.47 A C原子2530 CD2 LEU A 350 49.943 36.350 48.977 1.00 40.23 A C原子2531 C LEU A 350 52.939 33.537 50.636 1.00 48.97 A C原子2532 O LEU A 350 54.081 33.632 51.096 1.00 47.91 A O原子2533 N PRO A 351 52.423 32.362 50.261 1.00 49.92 A N原子2534 CD PRO A 351 51.025 32.123 49.856 1.00 49.34 A C原子2535 CA PRO A 351 53.167 31.103 50.358 1.00 50.91 A C原子2536 CB PRO A 351 52.199 30.105 49.729 1.00 51.84 A C原子2537 CG PRO A 351 50.854 30.656 50.147 1.00 49.35 A C原子2538 C PRO A 351 54.510 31.137 49.621 1.00 51.08 A C原子2539 O PRO A 351 55.435 30.391 49.956 1.00 51.03 A O原子2540 N ASN A 352 54.605 32.019 48.627 1.00 51.91 A N
原子2541 CA ASN A 352 55.819 32.165 47.830 1.00 51.60 A C原子2542 CB ASN A 352 55.488 32.575 46.388 1.00 53.18 A C原子2543 CG ASN A 352 54.492 33.720 46.313 1.00 54.15 A C原子2544 OD1 ASN A 352 54.857 34.882 46.523 1.00 54.22 A O原子2545 ND2 ASN A 352 53.221 33.397 46.007 1.00 53.45 A N原子2546 C ASN A 352 56.783 33.149 48.439 1.00 51.29 A C原子2547 O ASN A 352 57.821 33.432 47.866 1.00 51.94 A O原子2548 N GLY A 353 56.425 33.694 49.591 1.00 52.10 A N原子2549 CA GLY A 353 57.301 34.637 50.254 1.00 51.67 A C原子2550 C GLY A 353 57.033 36.093 49.924 1.00 52.59 A C原子2551 O GLY A 353 57.364 36.976 50.721 1.00 52.88 A O原子2552 N ARG A 354 56.434 36.354 48.764 1.00 52.20 A N原子2553 CA ARG A 354 56.131 37.723 48.355 1.00 52.91 A C原子2554 CB ARG A 354 55.795 37.733 46.867 1.00 54.87 A C原子2555 CG ARG A 354 56.859 37.012 46.055 1.00 58.36 A C原子2556 CD ARG A 354 56.491 36.885 44.598 1.00 60.35 A C原子2557 NE ARG A 354 56.715 38.114 43.846 1.00 62.57 A N原子2558 CZ ARG A 354 57.119 38.141 42.578 1.00 62.68 A C原子2559 NH1 ARG A 354 57.345 37.004 41.930 1.00 63.15 A N原子2560 NH2 ARG A 354 57.283 39.300 41.951 1.00 63.20 A N原子2561 C ARG A 354 55.012 38.369 49.189 1.00 52.68 A C原子2562 O ARG A 354 54.091 37.690 49.645 1.00 52.84 A O原子2563 N ASP A 355 55.114 39.675 49.423 1.00 52.60 A N原子2564 CA ASP A 355 54.104 40.391 50.209 1.00 51.13 A C原子2565 CB ASP A 355 54.472 41.868 50.315 1.00 52.98 A C原子2566 CG ASP A 355 55.022 42.228 51.662 1.00 55.75 A C原子2567 OD1 ASP A 355 56.168 41.827 51.964 1.00 56.98 A O原子2568 OD2 ASP A 355 54.303 42.912 52.420 1.00 58.14 A O
原子2569 C ASP A 355 52.709 40.304 49.609 1.00 48.48.33 A C原子2570 O ASP A 355 52.558 40.122 48.402 1.00 47.92 A O原子2571 N THR A 356 51.695 40.471 50.453 1.00 45.12 A N原子2572 CA THR A 356 50.318 40.453 49.985 1.00 41.61 A C原子2573 CB THR A 356 49.315 40.509 51.136 1.00 41.89 A C原子2574 OG1 THR A 356 49.610 41.641 51.967 1.00 43.46 A O原子2575 CG2 THR A 356 49.350 39.222 51.938 1.00 40.77 A C原子2576 C THR A 356 50.053 41.682 49.135 1.00 39.93 A C原子2577 O THR A 356 50.681 42.726 49.302 1.00 38.71 A O原子2578 N PRO A 357 49.106 41.568 48.202 1.00 38.90 A N原子2579 CD PRO A 357 48.306 40.379 47.877 1.00 38.06 A C原子2580 CA PRO A 357 48.754 42.683 47.327 1.00 37.44 A C原子2581 CB PRO A 357 47.750 42.052 46.357 1.00 37.15 A C原子2582 CG PRO A 357 48.028 40.598 46.426 1.00 37.65 A C原子2583 C PRO A 357 48.072 43.787 48.145 1.00 36.52 A C原子2584 O PRO A 357 47.899 43.670 49.371 1.00 35.18 A O原子2585 N ALA A 358 47.696 44.855 47.445 1.00 36.31 A N原子2586 CA ALA A 358 47.013 45.992 48.045 1.00 36.89 A C原子2587 CB ALA A 358 46.871 47.116 47.022 1.00 39.29 A C原子2588 C ALA A 358 45.642 45.503 48.460 1.00 36.54 A C原子2589 O ALA A 358 44.804 45.203 47.617 1.00 40.51 A O原子2590 N LEU A 359 45.418 45.376 49.753 1.00 33.58 A N原子2591 CA LEU A 359 44.135 44.911 50.197 1.00 31.97 A C原子2592 CB LEU A 359 44.319 43.680 51.079 1.00 31.56 A C原子2593 CG LEU A 359 44.939 42.380 50.578 1.00 30.94 A C原子2594 CD1 LEU A 359 45.021 41.419 51.745 1.00 27.42 A C原子2595 CD2 LEU A 359 44.102 41.782 49.456 1.00 27.95 A C原子2596 C LEU A 359 43.430 45.978 51.009 1.00 34.57 A C
原子2597 O LEU A 359 42.273 45.807 51.388 1.00 35.39 A O原子2598 N PHE A 360 44.110 47.079 51.295 1.00 35.45 A N原子2599 CA PHE A 360 43.479 48.083 52.128 1.00 36.39 A C原子2600 CB PHE A 360 44.128 48.080 53.507 1.00 37.60 A C原子2601 CG PHE A 360 44.351 46.699 54.062 1.00 39.23 A C原子2602 CD1 PHE A 360 45.633 46.197 54.217 1.00 36.41 A C原子2603 CD2 PHE A 360 43.270 45.902 54.427 1.00 41.40 A C原子2604 CE1 PHE A 360 45.841 44.935 54.723 1.00 37.04 A C原子2605 CE2 PHE A 360 43.470 44.628 54.939 1.00 42.88 A C原子2606 CZ PHE A 360 44.766 44.146 55.086 1.00 40.52 A C原子2607 C PHE A 360 43.432 49.492 51.591 1.00 37.54 A C原子2608 O PHE A 360 42.997 50.388 52.298 1.00 38.49 A O原子2609 N ASN A 361 43.824 49.691 50.338 1.00 37.15 A N原子2610 CA ASN A 361 43.813 51.028 49.758 1.00 38.30 A C原子2611 CB ASN A 361 44.779 51.087 48.573 1.00 40.99 A C原子2612 CG ASN A 361 44.603 49.920 47.631 1.00 42.98 A C原子2613 OD1 ASN A 361 43.681 49.127 47.807 1.00 46.33 A O原子2614 ND2 ASN A 361 45.492 49.791 46.637 1.00 42.76 A N原子2615 C ASN A 361 42.430 51.478 49.314 1.00 40.07 A C原子2616 O ASN A 361 42.260 51.910 48.178 1.00 41.25 A O原子2617 N PHE A 362 41.449 51.415 50.211 1.00 41.81 A N原子2618 CA PHE A 362 40.067 51.815 49.887 1.00 43.99 A C原子2619 CB PHE A 362 39.110 51.544 51.064 1.00 41.50 A C原子2620 CG PHE A 362 38.961 50.077 51.454 1.00 41.10 A C原子2621 CD1 PHE A 362 39.584 49.579 52.609 1.00 40.14 A C原子2622 CD2 PHE A 362 38.122 49.224 50.731 1.00 38.57 A C原子2623 CE1 PHE A 362 39.366 48.266 53.040 1.00 39.44 A C原子2624 CE2 PHE A 362 37.897 47.909 51.152 1.00 37.72 A C
原子2625 CZ PHE A 362 38.518 47.431 52.307 1.00 38.85 A C原子2626 C PHE A 362 39.949 53.303 49.548 1.00 46.68 A C原子2627 O PHE A 362 40.839 54.098 49.844 1.00 48.75 A O原子2628 N THR A 363 38.837 53.671 48.927 1.00 50.09 A N原子2629 CA THR A 363 38.571 55.057 48.587 1.00 53.08 A C原子2630 CB THR A 363 38.021 55.207 47.160 1.00 54.70 A C原子2631 OG1 THR A 363 38.520 54.160 46.324 1.00 58.50 A O原子2632 CG2 THR A 363 38.445 56.547 46.576 1.00 57.95 A C原子2633 C THR A 363 37.445 55.444 49.535 1.00 54.64 A C原子2634 O THR A 363 37.296 54.861 50.606 1.00 56.75 A O原子2635 N THR A 364 36.662 56.439 49.137 1.00 56.19 A N原子2636 CA THR A 364 35.505 56.907 49.898 1.00 54.68 A C原子2637 CB THR A 364 35.438 58.435 49.858 1.00 56.11 A C原子2638 OG1 THR A 364 35.506 58.875 48.491 1.00 54.01 A O原子2639 CG2 THR A 364 36.611 59.033 50.649 1.00 56.34 A C原子2640 C THR A 364 34.336 56.325 49.110 1.00 53.24 A C原子2641 O THR A 364 33.298 55.977 49.658 1.00 51.97 A O原子2642 N GLN A 365 34.573 56.187 47.808 1.00 52.95 A N原子2643 CA GLN A 365 33.627 55.627 46.859 1.00 52.88 A C原子2644 CB GLN A 365 34.192 55.742 45.439 1.00 54.99 A C原子2645 CG GLN A 365 33.253 55.259 44.346 1.00 58.42 A C原子2646 CD GLN A 365 31.930 56.000 44.343 1.00 60.34 A C原子2647 OE1 GLN A 365 31.857 57.164 44.740 1.00 62.13 A O原子2648 NE2 GLN A 365 30.871 55.323 43.902 1.00 61.74 A N原子2649 C GLN A 365 33.372 54.162 47.201 1.00 51.51 A C原子2650 O GLN A 365 32.220 53.732 47.261 1.00 52.21 A O原子2651 N GLU A 366 34.446 53.403 47.431 1.00 49.50 A N原子2652 CA GLU A 366 34.346 51.970 47.787 1.00 46.94 A C
原子2653 CB GLU A 366 35.732 51.313 47.880 1.00 45.51 A C原子2654 CG GLU A 366 36.589 51.362 46.633 1.00 46.49 A C原子2655 CD GLU A 366 37.812 50.471 46.750 1.00 46.59 A C原子2656 OE1 GLU A 366 38.905 50.882 46.300 1.00 48.74 A O原子2657 OE2 GLU A 366 37.677 49.350 47.278 1.00 43.88 A O原子2658 C GLU A 366 33.661 51.745 49.133 1.00 45.13 A C原子2659 O GLU A 366 33.024 50.715 49.361 1.00 43.49 A O原子2660 N LEU A 367 33.853 52.702 50.035 1.00 45.48 A N原子2661 CA LEU A 367 33.302 52.650 51.383 1.00 45.45 A C原子2662 CB LEU A 367 34.321 53.245 52.353 1.00 44.94 A C原子2663 CG LEU A 367 35.590 52.406 52.524 1.00 43.11 A C原子2664 CD1 LEU A 367 36.764 53.303 52.872 1.00 40.53 A C原子2665 CD2 LEU A 367 35.360 51.340 53.606 1.00 41.73 A C原子2666 C LEU A 367 31.953 53.362 51.515 1.00 47.21 A C原子2667 O LEU A 367 31.287 53.268 52.556 1.00 44.98 A O原子2668 N SER A 368 31.551 54.066 50.455 1.00 50.33 A N原子2669 CA SER A 368 30.269 54.777 50.452 1.00 53.30 A C原子2670 CB SER A 368 29.900 55.252 49.026 1.00 51.90 A C原子2671 OG SER A 368 29.543 54.189 48.160 1.00 51.58 A O原子2672 C SER A 368 29.198 53.831 51.041 1.00 55.02 A C原子2673 O SER A 368 28.481 54.180 51.979 1.00 56.62 A O原子2674 N SER A 369 29.154 52.608 50.525 1.00 56.53 A N原子2675 CA SER A 369 28.229 51.586 50.995 1.00 55.52 A C原子2676 CB SER A 369 28.736 50.210 50.521 1.00 56.85 A C原子2677 OG SER A 369 28.273 49.153 51.347 1.00 60.02 A O原子2678 C SER A 369 28.108 51.600 52.526 1.00 53.64 A C原子2679 O SER A 369 27.033 51.402 53.066 1.00 52.74 A O原子2680 N ASN A 370 29.196 51.885 53.227 1.00 53.25 A N
原子2681 CA ASN A 370 29.155 51.861 54.690 1.00 54.72 A C原子2682 CB ASN A 370 28.781 50.436 55.133 1.00 53.59 A C原子2683 CG ASN A 370 28.581 50.309 56.624 1.00 52.90 A C原子2684 OD1 ASN A 370 29.072 51.130 57.406 1.00 52.40 A O原子2685 ND2 ASN A 370 27.869 49.257 57.034 1.00 53.35 A N原子2686 C ASN A 370 30.524 52.287 55.269 1.00 56.11 A C原子2687 O ASN A 370 31.404 51.457 55.527 1.00 55.51 A O原子2688 N PRO A 371 30.723 53.601 55.454 1.00 56.66 A N原子2689 CD PRO A 371 29.897 54.707 54.940 1.00 56.97 A C原子2690 CA PRO A 371 31.982 54.113 55.989 1.00 56.41 A C原子2691 CB PRO A 371 31.762 55.622 55.955 1.00 55.85 A C原子2692 CG PRO A 371 30.925 55.796 54.732 1.00 55.46 A C原子2693 C PRO A 371 32.430 53.603 57.366 1.00 57.02 A C原子2694 O PRO A 371 33.626 53.487 57.619 1.00 59.45 A O原子2695 N PRO A 372 31.497 53.308 58.281 1.00 55.69 A N原子2696 CD PRO A 372 30.057 53.594 58.279 1.00 55.67 A C原子2697 CA PRO A 372 31.946 52.820 59.600 1.00 54.92 A C原子2698 CB PRO A 372 30.668 52.851 60.439 1.00 55.56 A C原子2699 CG PRO A 372 29.816 53.893 59.749 1.00 56.25 A C原子2700 C PRO A 372 32.569 51.417 59.631 1.00 55.36 A C原子2701 O PRO A 372 32.874 50.895 60.711 1.00 56.43 A O原子2702 N LEU A 373 32.689 50.784 58.462 1.00 55.09 A N原子2703 CA LEU A 373 33.281 49.438 58.349 1.00 53.58 A C原子2704 CB LEU A 373 32.701 48.662 57.151 1.00 50.84 A C原子2705 CG LEU A 373 31.470 47.783 57.401 1.00 49.68 A C原子2706 CD1 LEU A 373 31.241 46.918 56.175 1.00 49.06 A C原子2707 CD2 LEU A 373 31.667 46.909 58.633 1.00 46.66 A C原子2708 C LEU A 373 34.793 49.550 58.193 1.00 52.36 A C
原子2709 O LEU A 373 35.546 48.612 58.470 1.00 50.89 A O原子2710 N ALA A 374 35.221 50.715 57.732 1.00 50.53 A N原子2711 CA ALA A 374 36.621 50.969 57.547 1.00 48.79 A C原子2712 CB ALA A 374 36.830 52.392 57.095 1.00 49.05 A C原子2713 C ALA A 374 37.352 50.689 58.857 1.00 48.09 A C原子2714 O ALA A 374 38.554 50.436 58.850 1.00 50.11 A O原子2715 N THR A 375 36.631 50.691 59.976 1.00 46.43 A N原子2716 CA THR A 375 37.265 50.414 61.269 1.00 44.93 A C原子2717 CB THR A 375 36.285 50.632 62.456 1.00 44.95 A C原子2718 OG1 THR A 375 35.844 51.993 62.476 1.00 42.25 A O原子2719 CG2 THR A 375 36.971 50.303 63.794 1.00 45.26 A C原子2720 C THR A 375 37.797 48.972 61.321 1.00 45.05 A C原子2721 O THR A 375 38.819 48.700 61.959 1.00 44.91 A O原子2722 N ILE A 376 37.082 48.058 60.659 1.00 46.07 A N原子2723 CA ILE A 376 37.436 46.631 60.602 1.00 46.25 A C原子2724 CB ILE A 376 36.168 45.719 60.423 1.00 47.47 A C原子2725 CG2 ILE A 376 36.587 44.258 60.410 1.00 49.84 A C原子2726 CG1 ILE A 376 35.117 45.950 61.518 1.00 47.90 A C原子2727 CD1 ILE A 376 35.379 45.210 62.832 1.00 48.70 A C原子2728 C ILE A 376 38.328 46.358 59.377 1.00 45.31 A C原子2729 O ILE A 376 39.412 45.771 59.485 1.00 46.01 A O原子2730 N LEU A 377 37.832 46.788 58.219 1.00 42.65 A N原子2731 CA LEU A 377 38.484 46.605 56.929 1.00 40.14 A C原子2732 CB LEU A 377 37.644 47.251 55.842 1.00 37.52 A C原子2733 CG LEU A 377 36.236 46.720 55.598 1.00 34.72 A C原子2734 CD1 LEU A 377 35.498 47.655 54.649 1.00 32.35 A C原子2735 CD2 LEU A 377 36.300 45.311 55.046 1.00 32.96 A C原子2736 C LEU A 377 39.894 47.136 56.812 1.00 41.30 A C
原子2737 O LEU A 377 40.637 46.751 55.914 1.00 42.07 A O原子2738 N ILE A 378 40.245 48.061 57.687 1.00 42.94 A N原子2739 CA ILE A 378 41.572 48.663 57.674 1.00 43.58 A C原子2740 CB ILE A 378 41.464 50.174 57.318 1.00 41.23 A C原子2741 CG2 ILE A 378 42.838 50.784 57.156 1.00 40.66 A C原子2742 CG1 ILE A 378 40.657 50.333 56.021 1.00 41.34 A C原子2743 CD1 ILE A 378 40.715 51.714 55.390 1.00 38.27 A C原子2744 C ILE A 378 42.267 48.421 59.038 1.00 44.75 A C原子2745 O ILE A 378 41.972 49.088 60.044 1.00 44.69 A O原子2746 N PRO A 379 43.144 47.394 59.104 1.00 44.54 A N原子2747 CD PRO A 379 43.472 46.393 58.066 1.00 43.70 A C原子2748 CA PRO A 379 43.840 47.105 60.368 1.00 44.21 A C原子2749 CB PRO A 379 44.467 45.717 60.111 1.00 44.60 A C原子2750 CG PR0 A 379 44.729 45.731 58.623 1.00 43.70 A C原子2751 C PRO A 379 44.869 48.184 60.793 1.00 42.55 A C原子2752 O PRO A 379 45.392 48.933 59.965 1.00 40.25 A O原子2753 N PRO A 380 45.126 48.298 62.108 1.00 41.77 A N原子2754 CD PRO A 380 44.477 47.465 63.139 1.00 41.86 A C原子2755 CA PRO A 380 46.054 49.251 62.727 1.00 42.53 A C原子2756 CB PRO A 380 46.365 48.585 64.068 1.00 40.69 A C原子2757 CG PRO A 380 45.022 48.050 64.465 1.00 41.83 A C原子2758 C PRO A 380 47.316 49.608 61.944 1.00 42.81 A C原子2759 O PRO A 380 47.639 50.792 61.810 1.00 45.00 A O原子2760 N HIS A 381 48.005 48.588 61.420 1.00 43.34 A N原子2761 CA HIS A 381 49.259 48.744 60.659 1.00 41.55 A C原子2762 CB HIS A 381 50.013 47.398 60.562 1.00 40.10 A C原子2763 CG HIS A 381 49.301 46.357 59.750 1.00 38.99 A C原子2764 CD2 HIS A 381 48.395 45.412 60.105 1.00 37.41 A C
原子2765 ND1 HIS A 381 49.456 46.243 58.385 1.00 36.11 A N原子2766 CE1 HIS A 381 48.674 45.280 57.932 1.00 35.67 A C原子2767 NE2 HIS A 381 48.020 44.759 58.956 1.00 35.32 A N原子2768 C HIS A 381 49.147 49.352 59.260 1.00 41.65 A C原子2769 O HIS A 381 50.117 49.899 58.757 1.00 41.61 A O原子2770 N ALA A 382 47.999 49.188 58.604 1.00 44.05 A N原子2771 CA ALA A 382 47.781 49.737 57.259 1.00 44.82 A C原子2772 CB ALA A 382 46.907 48.805 56.429 1.00 44.94 A C原子2773 C ALA A 382 47.132 51.113 57.380 1.00 45.71 A C原子2774 O ALA A 382 47.020 51.849 56.385 1.00 42.45 A O原子2775 N ARG A 383 46.696 51.428 58.611 1.00 48.21 A N原子2776 CA ARG A 383 46.081 52.717 58.962 1.00 49.82 A C原子2777 CB ARG A 383 45.505 52.694 60.391 1.00 49.34 A C原子2778 CG ARG A 383 44.415 51.685 60.670 1.00 51.27 A C原子2779 CD ARG A 383 43.684 52.026 61.979 1.00 51.98 A C原子2780 NE ARG A 383 43.172 50.844 62.682 1.00 53.22 A N原子2781 CZ ARG A 383 41.970 50.756 63.251 1.00 54.13 A C原子2782 NH1 ARG A 383 41.135 51.781 63.190 1.00 56.67 A N原子2783 NH2 ARG A 383 41.622 49.666 63.933 1.00 53.27 A N原子2784 C ARG A 383 47.155 53.810 58.927 1.00 50.51 A C原子2785 O ARG A 383 48.083 53.788 59.744 1.00 51.82 A O原子2786 N ILE A 384 47.052 54.751 57.990 1.00 50.19 A N原子2787 CA ILE A 384 48.032 55.825 57.943 1.00 50.40 A C原子2788 CB ILE A 384 48.234 56.409 56.512 1.00 51.59 A C原子2789 CG2 ILE A 384 49.205 55.530 55.719 1.00 49.98 A C原子2790 CG1 ILE A 384 46.894 56.596 55.790 1.00 53.19 A C原子2791 CD1 ILE A 384 47.036 57.098 54.346 1.00 54.20 A C原子2792 C ILE A 384 47.717 56.925 58.975 1.00 51.15 A C
原子2793 OT1 ILE A 384 46.656 57.601 58.901 1.00 50.81 A O原子2794 OXT ILE A 384 48.541 57.045 59.909 1.00 51.15 A O TER 2795 ILE A 384 A原子2796 CB VAL B 1 22.328 39.735 28.119 1.00 81.87 B C原子2797 CG1 VAL B 1 23.701 39.102 27.940 1.00 82.12 B C原子2798 CG2 VAL B 1 22.307 41.115 27.469 1.00 80.67 B C原子2799 C VAL B 1 19.830 39.324 27.895 1.00 82.10 B C原子2800 O VAL B 1 19.035 38.597 28.497 1.00 82.19 B O原子2801 N VAL B 1 21.358 38.643 26.048 1.00 82.72 B N原子2802 CA VAL B 1 21.217 38.800 27.521 1.00 81.98 B C原子2803 N SEP B 2 19.515 40.545 27.461 1.00 81.49 B N原子2804 CA SEP B 2 18.236 41.185 27.778 1.00 80.59 B C原子2805 CB SEP B 2 18.484 42.644 28.142 1.00 75.26 B C原子2806 OG SEP B 2 17.792 43.018 29.313 1.00 67.40 B O原子2807 C SEP B 2 17.208 41.184 26.646 1.00 83.73 B C原子2808 O SEP B 2 16.557 40.176 26.361 1.00 83.80 B O原子2809 P SEP B 2 18.543 43.859 30.470 1.00 61.96 B P原子2810 O1P SEP B 2 18.083 45.275 30.375 1.00 63.44 B O原子2811 02P SEP B 2 18.130 43.447 31.826 1.00 59.37 B O原子2812 03P SEP B 2 19.970 43.523 30.331 1.00 64.76 B O原子2813 N ARG B 3 17.019 42.375 26.088 1.00 87.21 B N原子2814 CA ARG B 3 16.080 42.643 25.011 1.00 91.65 B C原子2815 CB ARG B 3 14.679 42.120 25.373 1.00 92.13 B C原子2816 CG ARG B 3 13.569 42.466 24.373 1.00 92.21 B C原子2817 CD ARG B 3 13.913 42.042 22.941 1.00 92.25 B C原子2818 NE ARG B 3 14.104 40.599 22.801 1.00 93.15 B N原子2819 CZ ARG B 3 14.938 40.033 21.930 1.00 93.75 B C原子2820 NH1 ARG B 3 15.665 40.789 21.113 1.00 93.91 B N原子2821 NH2 ARG B 3 15.053 38.711 21.879 1.00 93.24 B N
原子2822 C ARG B 3 16.068 44.164 24.911 1.00 94.89 B C原子2823 O ARG B 3 15.757 44.856 25.891 1.00 94.58 B O原子2824 N ARG B 4 16.439 44.677 23.740 1.00 98.73 B N原子2825 CA ARG B 4 16.497 46.119 23.509 1.00 103.02 B C原子2826 CB ARG B 4 17.252 46.404 22.203 1.00 101.19 B C原子2827 CG ARG B 4 17.736 47.837 22.086 1.00 100.25 B C原子2828 CD ARG B 4 18.906 47.974 21.123 1.00 99.56 B C原子2829 NE ARG B 4 19.576 49.262 21.303 1.00 98.46 B N原子2830 CZ ARG B 4 19.829 50.129 20.326 1.00 97.17 B C原子2831 NH1 ARG B 4 19.475 49.856 19.078 1.00 96.96 B N原子2832 NH2 ARG B 4 20.432 51.278 20.603 1.00 95.91 B N原子2833 C ARG B 4 15.121 46.814 23.504 1.00 107.14 B C原子2834 O ARG B 4 14.153 46.286 22.957 1.00 107.35 B O原子2835 N PRO B 5 15.016 48.000 24.143 1.00 111.23 B N原子2836 CD PRO B 5 16.051 48.646 24.972 1.00 112.66 B C原子2837 CA PRO B 5 13.753 48.756 24.202 1.00 113.91 B C原子2838 CB PRO B 5 14.097 49.945 25.119 1.00 113.87 B C原子2839 CG PRO B 5 15.595 50.092 24.979 1.00 113.39 B C原子2840 C PRO B 5 13.200 49.210 22.837 1.00 116.16 B C原子2841 O PRO B 5 13.957 49.492 21.904 1.00 116.49 B O原子2842 N SEP B 6 11.870 49.284 22.749 1.00 118.72 B N原子2843 CA SEP B 6 11.152 49.668 21.528 1.00 120.60 B C原子2844 CB SEP B 6 10.079 48.609 21.211 1.00 122.57 B C原子2845 OG SEP B 6 10.659 47.324 20.975 1.00 125.89 B O原子2846 P SEP B 6 10.404 46.005 21.940 1.00 127.40 B P原子2847 O1P SEP B 6 11.195 44.861 21.359 1.00 127.04 B O原子2848 02P SEP B 6 10.994 46.165 23.300 1.00 128.18 B O原子2849 03P SEP B 6 8.936 45.899 22.124 1.00 127.08 B O
原子2850 C SEP B 6 10.488 51.053 21.670 1.00 120.63 B C原子2851 OT1 SEP B 6 11.224 52.065 21.637 1.00 120.40 B O原子2852 OXT SEP B 6 9.241 51.115 21.795 1.00 120.72 B O TER 2853 SEP B 6 B原子2854 PB ADP C 96 33.471 35.320 29.692 1.00 47.42 ADP P原子2855 O1B ADP C 96 34.093 34.088 30.298 1.00 44.20 ADP O原子2856 02B ADP C 96 33.166 35.260 28.037 1.00 42.68 ADP O原子2857 03B ADP C 96 32.183 35.599 30.395 1.00 49.46 ADP O原子2858 PA ADP C 96 35.306 37.208 28.500 1.00 38.40 ADP P原子2859 O1A ADP C 96 35.895 38.477 28.913 1.00 33.24 ADP O原子2860 02A ADP C 96 34.315 37.309 27.357 1.00 35.71 ADP O原子2861 03A ADP C 96 34.554 36.496 29.734 1.00 42.89 ADP O原子2862 019 ADP C 96 36.409 36.135 28.135 1.00 40.70 ADP O原子2863 C18 ADP C 96 37.739 36.445 27.762 1.00 39.43 ADP C原子2864 C17 ADP C 96 38.549 35.237 28.242 1.00 37.73 ADP C原子2865 016 ADP C 96 39.926 35.405 27.909 1.00 39.45 ADP O原子2866 C15 ADP C 96 38.492 35.023 29.765 1.00 38.02 ADP C原子2867 014 ADP C 96 37.745 33.880 30.173 1.00 37.38 ADP O原子2868 C13 ADP C 96 39.902 34.896 30.270 1.00 38.92 ADP C原子2869 012 ADP C 96 40.146 33.587 30.794 1.00 39.07 ADP O原子2870 C11 ADP C 96 40.774 35.244 29.080 1.00 41.85 ADP C原子2871 N10 ADP C 96 41.712 36.455 29.364 1.00 41.53 ADP N原子2872 C9 ADP C 96 43.062 36.353 29.559 1.00 39.70 ADP C原子2873 N8 ADP C 96 43.587 37.564 29.772 1.00 36.28 ADP N原子2874 C7 ADP C 96 42.619 38.435 29.740 1.00 39.29 ADP C原子2875 C6 ADP C 96 42.542 39.796 29.859 1.00 39.23 ADP C原子2876 N5 ADP C 96 43.633 40.519 30.114 1.00 37.34 ADP N原子2877 N4 ADP C 96 41.339 40.405 29.755 1.00 44.99 ADP N原子2878 C3 ADP C 96 40.202 39.702 29.497 1.00 42.78 ADP C
原子2879 N2 ADP C 96 40.262 38.385 29.362 1.00 38.79 ADP N原子2880 C1 ADP C 96 41.408 37.721 29.450 1.00 38.91 ADP C TER 2881 ADP C 96 ADP原子2882 OH2 TIP 1 37.614 24.548 42.639 1.00 30.08 S O原子2883 OH2 TIP 2 32.674 26.543 36.071 1.00 29.91 S O原子2884 OH2 TIP 3 28.976 48.935 47.768 1.00 28.66 S O原子2885 OH2 TIP 4 37.738 22.847 51.778 1.00 33.12 S O原子2886 OH2 TIP 5 43.802 47.292 37.017 1.00 28.37 S O原子2887 OH2 TIP 6 49.392 29.259 42.658 1.00 32.65 S O原子2888 OH2 TIP 7 38.998 50.786 32.685 1.00 25.50 S O原子2889 OH2 TIP 8 36.790 23.947 39.558 1.00 33.61 S O原子2890 OH2 TIP 9 39.779 30.462 32.033 1.00 25.94 S O原子2891 OH2 TIP 10 23.267 28.801 41.609 1.00 27.49 S O原子2892 OH2 TIP 11 26.713 37.609 38.682 1.00 24.60 S O原子2893 OH2 TIP 12 27.633 26.163 41.315 1.00 21.83 S O原子2894 OH2 TIP 13 43.665 33.333 30.694 1.00 35.98 S O原子2895 OH2 TIP 14 40.153 27.668 30.495 1.00 32.97 S O原子2896 OH2 TIP 15 43.621 41.169 16.055 1.00 41.82 S O原子2897 OH2 TIP 16 44.310 24.341 34.334 1.00 34.18 S O原子2898 OH2 TIP 17 51.648 27.387 48.125 1.00 53.31 S O原子2899 OH2 TIP 18 29.611 34.850 60.678 1.00 47.87 S O原子2900 OH2 TIP 19 23.146 35.582 40.243 1.00 28.50 S O原子2901 OH2 TIP 20 37.034 42.300 30.493 1.00 33.58 S O原子2902 OH2 TIP 21 47.884 47.445 36.937 1.00 32.44 S O原子2903 OH2 TIP 22 32.467 37.655 60.695 1.00 37.71 S O原子2904 OH2 TIP 23 41.786 51.156 43.578 1.00 44.25 S O原子2905 OH2 TIP 24 30.713 26.255 60.849 1.00 34.45 S O原子2906 OH2 TIP 25 43.060 53.870 32.088 1.00 44.99 S O原子2907 OH2 TIP 26 52.130 53.156 24.222 1.00 44.73 S O
原子2908 OH2 TIP 27 24.267 29.21 31.552 1.00 38.95 S O原子2909 OH2 TIP 28 49.120 45.157 44.532 1.00 42.88 S O原子2910 OH2 TIP 29 43.249 52.213 41.174 1.00 33.64 S O原子2911 OH2 TIP 30 9.208 48.177 40.018 1.00 42.03 S O原子2912 OH2 TIP 31 16.850 50.229 18.553 1.00 58.28 S O原子2913 OH2 TIP 32 50.662 43.082 54.636 1.00 36.48 S O原子2914 OH2 TIP 33 13.439 37.991 31.209 1.00 33.60 S O原子2915 OH2 TIP 34 25.684 17.185 52.610 1.00 43.92 S O原子2916 OH2 TIP 35 28.975 19.204 43.354 1.00 42.57 S O原子2917 OH2 TIP 36 33.283 22.454 62.532 1.00 51.22 S O原子2918 OH2 TIP 37 22.186 29.863 54.142 1.00 46.37 S O原子2919 OH2 TIP 38 27.789 32.961 61.168 1.00 51.05 S O原子2920 OH2 TIP 39 24.049 53.393 43.944 1.00 37.40 S O原子2921 OH2 TIP 40 49.154 31.325 55.519 1.00 30.82 S O原子2922 OH2 TIP 41 54.775 41.195 45.154 1.00 43.68 S O原子2923 OH2 TIP 42 47.369 47.566 9.871 1.00 41.01 S O原子2924 OH2 TIP 43 54.622 36.086 29.775 1.00 37.49 S O原子2925 OH2 TIP 44 40.435 46.225 9.607 1.00 41.30 S O原子2926 OH2 TIP 45 22.035 27.764 57.363 1.00 45.26 S O原子2927 OH2 TIP 46 33.267 31.533 29.843 1.00 40.42 S O原子2928 OH2 TIP 47 21.762 47.364 45.382 1.00 38.82 S O原子2929 OH2 TIP 48 58.121 44.019 53.336 1.00 48.52 S O原子2930 OH2 TIP 49 36.765 56.356 41.574 1.00 54.37 S O原子2931 OH2 TIP 50 24.534 43.501 29.287 1.00 41.69 S O原子2932 OH2 TIP 51 35.058 20.889 50.922 1.00 48.01 S O原子2933 OH2 TIP 52 13.886 39.904 42.973 1.00 56.12 S O原子2934 OH2 TIP 53 16.328 35.883 23.460 1.00 48.03 S O原子2935 OH2 TIP 54 19.016 58.276 40.961 1.00 56.32 S O
原子2936 OH2 TIP 55 41.544 40.262 2.500 1.00 46.18 S O原子2937 OH2 TIP 56 44.279 55.225 57.112 1.00 42.91 S O原子2938 OH2 TIP 57 14.621 26.661 53.689 1.00 40.46 S O原子2939 OH2 TIP 58 22.480 50.514 26.918 1.00 48.08 S O原子2940 OH2 TIP 59 40.544 58.184 45.516 1.00 36.43 S O原子2941 OH2 TIP 60 28.046 57.913 39.878 1.00 51.50 S O原子2942 OH2 TIP 61 39.964 53.691 60.049 1.00 45.68 S O原子2943 OH2 TIP 62 41.938 63.496 30.969 1.00 54.21 S O原子2944 OH2 TIP 63 35.807 21.046 38.176 1.00 43.54 S O原子2945 OH2 TIP 64 22.071 38.798 14.766 1.00 47.50 S O原子2946 OH2 TIP 65 52.246 34.086 16.948 1.00 56.85 S O原子2947 OH2 TIP 66 12.969 46.862 37.866 1.00 48.26 S O原子2948 OH2 TIP 67 32.618 34.031 20.366 1.00 47.96 S O原子2949 OH2 TIP 68 42.491 44.502 14.078 1.00 43.80 S O原子2950 OH2 TIP 69 28.879 18.119 48.981 1.00 47.32 S O原子2951 OH2 TIP 70 47.866 26.718 35.776 1.00 43.68 S O原子2952 OH2 TIP 71 51.653 29.326 53.522 1.00 50.51 S O原子2953 OH2 TIP 72 27.530 27.567 34.559 1.00 36.31 S O原子2954 OH2 TIP 73 43.448 35.329 61.731 1.00 46.58 S O原子2955 OH2 TIP 74 13.760 44.396 53.266 1.00 43.30 S O原子2956 OH2 TIP 75 49.912 51.983 34.635 1.00 39.49 S O原子2957 OH2 TIP 76 47.211 48.560 50.927 1.00 29.73 S O原子2958 OH2 TIP 77 20.660 23.190 58.655 1.00 58.96 S O原子2959 OH2 TIP 78 25.392 41.268 12.909 1.00 50.54 S O原子2960 OH2 TIP 79 18.414 53.555 42.040 1.00 33.95 S O原子2961 OH2 TIP 80 38.389 48.986 34.941 1.00 37.30 S O原子2962 OH2 TIP 81 30.056 44.675 22.094 1.00 49.21 S O原子2963 OH2 TIP 82 33.883 32.890 62.125 1.00 47.01 S O
原子2964 OH2 TIP 83 14.141 46.463 20.036 1.00 49.20 S O原子2965 OH2 TIP 84 32.345 16.403 51.561 1.00 59.53 S O原子2966 OH2 TIP 85 16.280 42.332 47.016 1.00 54.91 S O原子2967 OH2 TIP 86 56.299 43.978 62.800 1.00 53.85 S O原子2968 OH2 TIP 87 39.623 52.317 13.650 1.00 53.90 S O原子2969 OH2 TIP 88 3.822 34.078 53.161 1.00 45.64 S O原子2970 OH2 TIP 89 46.952 21.914 48.519 1.00 36.91 S O原子2971 OH2 TIP 90 44.388 13.268 47.302 1.00 55.98 S O原子2972 OH2 TIP 91 25.913 23.929 60.193 1.00 69.29 S O原子2973 OH2 TIP 92 15.259 25.158 31.304 1.00 49.66 S O原子2974 OH2 TIP 93 40.649 56.382 53.093 1.00 49.07 S O原子2975 OH2 TIP 94 17.371 27.378 53.774 1.00 43.50 S O原子2976 OH2 TIP 95 36.389 21.782 35.209 1.00 44.35 S O原子2977 OH2 TIP 96 44.744 39.555 6.616 1.00 46.67 S O原子2978 OH2 TIP 97 9.970 44.788 37.824 1.00 44.81 S O原子2979 OH2 TIP 98 24.129 43.481 48.119 1.00 42.31 S O原子2980 OH2 TIP 99 38.604 65.156 21.999 1.00 39.47 S O原子2981 OH2 TIP 100 60.337 48.176 25.733 1.00 48.72 S O原子2982 OH2 TIP 101 22.010 24.865 54.650 1.00 38.82 S O原子2983 OH2 TIP 102 30.955 41.414 25.553 1.00 53.24 S O原子2984 OH2 TIP 103 49.651 26.977 31.613 1.00 48.95 S O原子2985 OH2 TIP 104 56.482 49.787 30.885 1.00 65.25 S O原子2986 OH2 TIP 105 46.340 45.344 43.520 1.00 45.31 S O原子2987 OH2 TIP 106 14.977 28.933 32.619 1.00 38.78 S O原子2988 OH2 TIP 107 56.104 37.575 58.211 1.00 47.83 S O原子2989 OH2 TIP 108 41.940 44.597 62.550 1.00 57.32 S O原子2990 OH2 TIP 109 45.687 50.954 43.171 1.00 42.89 S O原子2991 OH2 TIP 110 2.086 39.603 38.590 1.00 66.59 S O
原子2992 OH2 TIP 111 40.351 24.401 60.082 1.00 75.01 S O原子2993 OH2 TIP 112 19.111 38.206 18.146 1.00 41.19 S O原子2994 OH2 TIP 113 43.454 37.606 63.990 1.00 62.50 S O原子2995 OH2 TIP 114 42.139 20.942 29.257 1.00 40.32 S O原子2996 OH2 TIP 115 41.880 51.132 36.408 1.00 39.00 S O原子2997 OH2 TIP 116 31.511 29.105 62.997 1.00 41.99 S O原子2998 OH2 TIP 117 51.119 40.450 33.476 1.00 38.15 S O原子2999 OH2 TIP 118 49.058 46.834 53.066 1.00 55.54 S O原子3000 OH2 TIP 119 27.461 24.253 31.296 1.00 49.05 S O原子3001 OH2 TIP 120 26.884 19.778 47.851 1.00 42.39 S O原子3002 OH2 TIP 121 57.142 42.263 48.872 1.00 42.97 S O原子3003 OH2 TIP 122 59.011 41.470 44.710 1.00 46.77 S O原子3004 OH2 TIP 123 9.437 42.980 32.259 1.00 39.15 S O原子3005 OH2 TIP 124 43.418 56.347 41.714 1.00 39.04 S O原子3006 OH2 TIP 125 47.258 19.642 37.741 1.00 29.93 S O原子3007 OH2 TIP 126 38.114 44.410 64.709 1.00 49.06 S O原子3008 OH2 TIP 127 55.332 29.406 45.454 1.00 62.34 S O原子3009 OH2 TIP 128 49.121 55.958 11.620 1.00 47.32 S 0原子3010 OH2 TIP 129 51.937 41.204 45.436 1.00 41.64 S O原子3011 OH2 TIP 130 38.419 61.242 32.284 1.00 52.63 S O原子3012 OH2 TIP 131 26.891 31.505 25.814 1.00 48.64 S O原子3013 OH2 TIP 132 21.947 15.755 57.484 1.00 51.94 S O原子3014 OH2 TIP 133 19.192 16.280 54.429 1.00 57.94 S O原子3015 OH2 TIP 134 49.652 24.281 50.748 1.00 54.31 S O原子3016 OH2 TIP 135 45.871 54.230 27.371 1.00 46.12 S O原子3017 OH2 TIP 136 34.044 58.747 38.213 1.00 53.08 S O原子3018 OH2 TIP 137 20.834 14.951 47.923 1.00 79.72 S O原子3019 OH2 TIP 138 11.234 46.371 26.007 1.00 41.81 S O
原子3020 OH2 TIP 139 21.863 36.871 23.804 1.00 54.35 S O原子3021 OH2 TIP 140 40.464 33.664 60.063 1.00 49.84 S O原子3022 OH2 TIP 141 8.216 47.553 26.261 1.00 60.31 S O原子3023 OH2 TIP 142 51.926 45.284 47.051 1.00 51.74 S O原子3024 OH2 TIP 143 17.335 48.464 28.268 1.00 109.91 S O原子3025 OH2 TIP 144 28.841 43.961-1.494 1.00 53.54 S O原子3026 OH2 TIP 145 30.365 27.938 33.491 1.00 70.00 S O原子3027 OH2 TIP 146 20.509 44.273 49.023 1.00 49.63 S O原子3028 OH2 TIP 147 33.412 14.069 41.724 1.00 67.32 S O原子3029 OH2 TIP 148 55.179 32.407 53.701 1.00 48.38 S O原子3030 OH2 TIP 149 29.898 47.226 2.890 1.00 48.69 S O原子3031 OH2 TIP 150 18.125 28.926 26.869 1.00 44.15 S O原子3032 OH2 TIP 151 49.583 59.244 21.010 1.00 58.07 S O原子3033 OH2 TIP 152 52.174 34.230 28.143 1.00 48.65 S O原子3034 OH2 TIP 153 28.121 57.015 52.739 1.00 38.58 S O原子3035 OH2 TIP 154 44.194 28.871 57.719 1.00 57.76 S O原子3036 OH2 TIP 155 25.750 35.717 31.227 1.00 41.59 S O原子3037 OH2 TIP 156 53.171 47.082 59.301 1.00 44.51 S O原子3038 OH2 TIP 157 40.024 16.950 43.163 1.00 47.16 S O原子3039 OH2 TIP 1 30.135 26.823 42.209 1.00 38.18 S2 O原子3040 OH2 TIP 2 26.740 27.035 61.214 1.00 54.62 S2 O原子3041 OH2 TIP 3 37.111 63.675 28.567 1.00 53.33 S2 O原子3042 OH2 TIP 4 45.585 60.276 59.473 1.00 45.06 S2 O原子3043 OH2 TIP 5 44.287 33.287 65.508 1.00 54.07 S2 O原子3044 OH2 TIP 6 18.122 14.745 47.303 1.00 59.76 S2 O原子3045 OH2 TIP 7 31.081 41.110 6.258 1.00 55.31 S2 O原子3046 OH2 TIP 8 32.117 35.049 62.410 1.00 55.71 S2 O原子3047 OH2 TIP 9 23.264 34.646 25.434 1.00 48.22 S2 O
原子3048 OH2 TIP 10 11.942 47.740 28.204 1.00 52.81 S2 O原子3049 OH2 TIP 11 51.500 30.621 35.783 1.00 43.93 S2 O原子3050 OH2 TIP 12 44.436 57.094 39.270 1.00 46.42 S2 O原子3051 OH2 TIP 13 50.631 25.488 46.243 1.00 58.86 S2 O原子3052 OH2 TIP 14 48.345 31.234 30.399 1.00 50.48 S2 O原子3053 OH2 TIP 15 12.196 43.594 45.699 1.00 62.40 S2 O原子3054 OH2 TIP 16 52.735 30.385 40.337 1.00 59.49 S2 0原子3055 OH2 TIP 17-0.876 28.719 40.420 1.00 65.29 S2 O原子3056 OH2 TIP 18 9.956 38.515 28.872 1.00 61.25 S2 O原子3057 OH2 TIP 19 33.912 9.937 41.712 1.00 54.20 S2 O原子3058 OH2 TIP 20 40.701 23.793 28.102 1.00 53.91 S2 O原子3059 OH2 TIP 21 22.786 59.706 41.265 1.00 60.58 S2 O原子3060 OH2 TIP 22 47.763 53.128 36.131 1.00 72.78 S2 O原子3061 OH2 TIP 23 36.918 62.026 45.954 1.00 60.21 S2 O原子3062 OH2 TIP 24 18.732 38.110 58.060 1.00 50.61 S2 O原子3063 OH2 TIP 25 29.752 20.272 35.535 1.00 52.93 S2 O原子3064 OH2 TIP 26 32.263 26.225 66.071 1.00 65.79 S2 O原子3065 OH2 TIP 27 46.076 49.812 40.653 1.00 44.93 S2 O原子3066 OH2 TIP 28 52.282 26.343 31.282 1.00 50.78 S2 O原子3067 OH2 TIP 29 30.710 60.585 38.033 1.00 62.34 S2 O原子3068 OH2 TIP 30 29.436 28.269 66.530 1.00 72.80 S2 O原子3069 OH2 TIP 31 12.312 41.678 31.485 1.00 62.00 S2 O原子3070 OH2 TIP 32 48.531 49.645 45.658 1.00 56.81 S2 O原子3071 OH2 TIP 33 17.275 48.625 44.781 1.00 49.79 S2 O原子3072 OH2 TIP 34 34.720 24.509 32.066 1.00 54.66 S2 O原子3073 OH2 TIP 35 35.003 36.100 11.946 1.00 60.45 S2 O原子3074 OH2 TIP 36 24.570 31.918 59.493 1.00 65.83 S2 O原子3075 OH2 TIP 37 26.346 47.555 48.204 1.00 59.47 S2 O
原子3076 OH2 TIP 38 17.855 47.113 48.430 1.00 59.77 S2 O原子3077 OH2 TIP 39 8.868 27.656 37.861 1.00 58.94 S2 O原子3078 OH2 TIP 40 52.463 45.676 64.501 1.00 53.60 S2 O原子3079 OH2 TIP 41 34.986 57.302 53.223 1.00 68.37 S2 O原子3080 OH2 TIP 42 27.614 56.546 45.392 1.00 60.22 S2 O原子3081 OH2 TIP 43 54.387 35.092 59.734 1.00 63.06 S2 O原子3082 OH2 TIP 44 34.307 22.272 59.708 1.00 58.20 S2 O原子3083 OH2 TIP 45 31.482 17.307 59.598 1.00 66.86 S2 O原子3084 OH2 TIP 46 38.629 28.849 26.984 1.00 67.10 S2 O原子3085 OH2 TIP 47 17.339 49.418 30.900 1.00 60.39 S2 O原子3086 OH2 TIP 48 7.548 16.489 51.658 1.00 69.42 S2 O原子3087 OH2 TIP 49 43.887 67.501 23.936 1.00 50.86 S2 O原子3088 OH2 TIP 50 49.064 46.587 40.492 1.00 59.08 S2 O原子3089 OH2 TIP 51 45.936 53.901 51.981 1.00 55.31 S2 O原子3090 OH2 TIP 52 16.008 46.876 17.581 1.00 50.50 S2 O原子3091 OH2 TIP 53 16.553 46.946 42.091 1.00 55.64 S2 O原子3092 OH2 TIP 54 18.327 16.162 35.532 1.00 55.08 S2 O原子3093 OH2 TIP 55 29.189 28.138 30.559 1.00 50.26 S2 O原子3094 OH2 TIP 56 22.622 31.452 28.529 1.00 54.49 S2 O原子3095 OH2 TIP 57 56.809 35.090 18.492 1.00 80.17 S2 O原子3096 OH2 TIP 58 36.986 40.916 61.883 1.00 62.46 S2 O原子3097 OH2 TIP 59 38.678 53.126 43.052 1.00 51.60 S2 O原子3098 OH2 TIP 60 33.936 60.318 21.616 1.00 68.61 S2 O原子3099 OH2 TIP 61 21.246 57.192 42.724 1.00 54.85 S2 O原子3100 OH2 TIP 62 52.196 28.620 28.356 1.00 66.46 S2 O原子3101 OH2 TIP 63 51.548 52.552 29.029 1.00 57.51 S2 O原子3102 OH2 TIP 64 28.623 46.815 50.133 1.00 95.47 S2 O原子3103 OH2 TIP 65 0.980 38.378 36.256 1.00 58.96 S2 O
原子3104 OH2 TIP 66 39.816 24.300 45.030 1.00 46.36 S2 O原子3105 OH2 TIP 67 17.241 34.153 21.709 1.00 69.76 S2 O原子3106 OH2 TIP 68 60.457 39.363 54.183 1.00 54.30 S2 O原子3107 OH2 TIP 69 29.664 10.401 58.320 1.00 51.22 S2 O原子3108 OH2 TIP 70 51.986 46.814 50.070 1.00 63.48 S2 O原子3109 OH2 TIP 71 49.739 45.640 32.649 1.00 68.23 S2 O原子3110 OH2 TIP 72 12.027 54.886 36.495 1.00 55.37 S2 O原子3111 OH2 TIP 73 44.385 54.827 45.868 1.00 58.74 S2 O原子3112 OH2 TIP 74 51.888 27.430 56.253 1.00 52.15 S2 O原子3113 OH2 TIP 75 45.620 32.466 61.384 1.00 66.18 S2 O原子3114 OH2 TIP 76 40.285 46.837 64.089 1.00 63.00 S2 O原子3115 OH2 TIP 77 52.804 46.032 44.106 1.00 77.31 S2 O原子3116 OH2 TIP 78 40.983 40.978 61.850 1.00 51.00 S2 O结束表3注释 精细化分辨率50.0-2.6_注释 起始r＝0.2425游离_r＝0.3110注释 最终r＝0.2388游离_r＝0.3157注释 Brmsd键＝0.014399 rmsd角＝1.97234注释 wa＝5.28293注释 目标＝mlf循环＝1步＝150注释 sg＝P2(1)a＝56.855 b＝65.194 c＝57.372 α＝90 β＝100.504 γ＝90注释 参数文件1MSL_CNX_TOPPARProtein.param注释 参数文件2../pagtp_10mM/Model/sep.par注释 参数文件3MSL_CNX_TOPPARion.param注释 参数文件4MSI_CNX_TOPPARwater_rep.param注释 参数文件5911.par注释 分子结构文件water_pick2_hr1.psf注释 输入坐标bind_wp.pdb
注释 反射文件＝gsk3_73911_amalgam.fob.cv注释 ncs＝无注释 B-纠正率6.0-2.6注释 起始B-因子纠正用于fobs注释 B11＝-15.378 B22＝6.692 B33＝8.686注释 B12＝0.000 B13＝2.330 B23＝0.000注释 B-因子纠正用于坐标阵列B0.538注释 大量分辨(光罩)密度水平＝0.267943e/A^3，B-因子＝14.8853A^2注释 反射|Fobs|/∑_F＜0.0被排斥注释 反射|Fobs|＞10000*rms(Fobs)被排斥注释 分辨范围中refl.的理论总数12818(100.0％)注释 未观测到反射的数量(未进入或|F|＝0)271(2.1％)注释 反射被排斥的数量0(0.0％)注释 反射被利用的总数12547(97.9％)注释 工作状态反射数量11903(92.9％)注释 测试状态反射数量644(5.0％)注释 由CNX VERSION记录2000原子1 CB VAL A 37-20.449 37.645 27.079 1.00 63.97 A C原子2 CG1 VAL A 37-21.351 38.789 27.514 1.00 64.03 A C原子3 CG2 VAL A 37-19.103 37.768 27.790 1.00 63.72 A C原子4 C VAL A 37-20.407 35.089 26.711 1.00 64.64 A C原子5 O VAL A 37-19.588 35.268 25.797 1.00 65.48 A O原子6 N VAL A 37-21.261 36.056 28.866 1.00 61.85 A N原子7 CA VAL A 37-21.133 36.269 27.393 1.00 63.68 A C原子8 N THR A 38-20.815 33.881 27.097 1.00 65.62 A N原子9 CA THR A 38-20.235 32.624 26.607 1.00 65.68 A C原子10 CB THR A 38-20.230 31.548 27.746 1.00 65.84 A C原子11 OG1 THR A 38-19.759 30.289 27.241 1.00 63.83 A O原子12 CG2 THR A 38-21.627 31.388 28.376 1 00 66.38 A C
原子13 C THR A 38-20.773 32.000 25.313 1.00 66.01 A C原子14 O THR A 38-21.974 32.027 25.048 1.00 66.82 A O原子15 N THR A 39-19.849 31.440 24.524 1.00 66.48 A N原子16 CA THR A 39-20.146 30.750 23.260 1.00 66.51 A C原子17 CB THR A 39-19.504 31.445 22.030 1.00 66.18 A C原子18 OG1 THR A 39-18.100 31.579 22.244 1.00 66.67 A O原子19 CG2 THR A 39-20.117 32.823 21.770 1.00 65.27 A C原子20 C THR A 39-19.567 29.333 23.374 1.00 67.41 A C原子21 O THR A 39-18.631 29.113 24.148 1.00 67.02 A O原子22 N VAL A 40-20.104 28.397 22.584 1.00 68.28 A N原子23 CA VAL A 40-19.677 26.988 22.594 1.00 68.51 A C原子24 CB VAL A 40-20.667 26.118 23.479 1.00 68.79 A C原子25 CG1 VAL A 40-22.118 26.231 22.990 1.00 69.33 A C原子26 CG2 VAL A 40-20.221 24.663 23.556 1.00 68.92 A C原子27 C VAL A 40-19.478 26.393 21.179 1.00 68.20 A C原子28 O VAL A 40-20.371 26.473 20.327 1.00 69.61 A O原子29 N VAL A 41-18.290 25.825 20.940 1.00 67.45 A N原子30 CA VAL A 41-17.918 25.211 19.645 1.00 67.05 A C原子31 CB VAL A 41-17.101 26.200 18.747 1.00 67.26 A C原子32 CG1 VAL A 41-18.021 27.220 18.080 1.00 67.96 A C原子33 CG2 VAL A 41-16.010 26.902 19.558 1.00 67.07 A C原子34 C VAL A 41-17.107 23.903 19.782 1.00 66.87 A C原子35 O VAL A 41-16.795 23.484 20.900 1.00 66.42 A O原子36 N ALA A 42-16.794 23.263 18.645 1.00 66.67 A N原子37 CA ALA A 42-16.001 22.018 18.601 1.00 66.46 A C原子38 CB ALA A 42-16.867 20.815 18.232 1.00 66.57 A C原子39 C ALA A 42-14.836 22.162 17.621 1.00 66.09 A C原子40 O ALA A 42-15.012 22.703 16.523 1.00 64.72 A O
原子41 N THR A 43-13.672 21.611 17.998 1.00 66.01 A N原子42 CA THR A 43-12.434 21.733 17.202 1.00 66.68 A C原子43 CB THR A 43-11.813 23.120 17.490 1.00 66.24 A C原子44 OG1 THR A 43-10.514 23.207 16.894 1.00 66.38 A O原子45 CG2 THR A 43-11.730 23.369 18.985 1.00 66.90 A C原子46 C THR A 43-11.324 20.669 17.440 1.00 66.97 A C原子47 O THR A 43-11.276 20.085 18.525 1.00 68.13 A O原子48 N PRO A 44-10.428 20.408 16.432 1.00 66.74 A N原子49 CD PRO A 44-10.691 20.633 14.992 1.00 66.39 A C原子50 CA PRO A 44-9.327 19.424 16.563 1.00 67.07 A C原子51 CB PRO A 44-8.960 19.126 15.105 1.00 66.81 A C原子52 CG PRO A 44-10.225 19.359 14.377 1.00 67.07 A C原子53 C PRO A 44-8.064 19.811 17.381 1.00 67.23 A C原子54 O PRO A 44-7.847 19.283 18.477 1.00 65.63 A O原子55 N GLY A 45-7.205 20.656 16.804 1.00 67.43 A N原子56 CA GLY A 45-5.986 21.082 17.473 1.00 68.55 A C原子57 C GLY A 45-4.696 20.544 16.879 1.00 70.54 A C原子58 O GLY A 45-4.734 19.644 16.036 1.00 70.42 A O原子59 N GLN A 46-3.562 21.093 17.340 1.00 72.31 A N原子60 CA GLN A 46-2.196 20.716 16.912 1.00 73.38 A C原子61 CB GLN A 46-1.167 21.740 17.463 1.00 74.35 A C原子62 CG GLN A 46 0.284 21.243 17.805 1.00 75.04 A C原子63 CD GLN A 46 1.269 21.245 16.638 1.00 76.02 A C原子64 OE1 GLN A 46 2.306 21.916 16.687 1.00 74.90 A O原子65 NE2 GLN A 46 0.977 20.453 15.611 1.00 76.72 A N原子66 C GLN A 46-1.784 19.277 17.272 1.00 73.69 A C原子67 O GLN A 46-1.204 18.576 16.438 1.00 73.44 A O原子68 N GLY A 47-2.076 18.858 18.506 1.00 74.61 A N
原子69 CA GLY A 47-1.729 17.518 18.967 1.00 76.25 A C原子70 C GLY A 47-2.553 16.398 18.337 1.00 77.59 A C原子71 O GLY A 47-2.708 16.388 17.104 1.00 77.93 A O原子72 N PRO A 48-3.063 15.420 19.128 1.00 78.09 A N原子73 CD PRO A 48-2.811 15.193 20.566 1.00 78.23 A C原子74 CA PRO A 48-3.869 14.321 18.566 1.00 78.51 A C原子75 CB PRO A 48-4.083 13.392 19.772 1.00 78.25 A C原子76 CG PRO A 48-3.962 14.308 20.961 1.00 77.68 A C原子77 C PRO A 48-5.189 14.810 17.952 1.00 78.48 A C原子78 O PRO A 48-5.930 15.573 18.587 1.00 78.17 A O原子79 N ASP A 49-5.421 14.421 16.693 1.00 78.11 A N原子80 CA ASP A 49-6.618 14.799 15.925 1.00 77.95 A C原子81 CB ASP A 49-6.440 14.398 14.449 1.00 78.50 A C原子82 CG ASP A 49-7.387 15.145 13.511 1.00 78.95 A C原子83 OD1 ASP A 49-6.886 15.921 12.668 1.00 78.90 A O原子84 OD2 ASP A 49-8.622 14.953 13.604 1.00 78.68 A O原子85 C ASP A 49-7.888 14.172 16.521 1.00 77.47 A C原子86 O ASP A 49-8.339 13.098 16.100 1.00 78.29 A O原子87 N ARG A 50-8.452 14.882 17.496 1.00 76.39 A N原子88 CA ARG A 50-9.645 14.458 18.219 1.00 74.91 A C原子89 CB ARG A 50-9.225 13.719 19.504 1.00 77.01 A C原子90 CG ARG A 50-10.371 13.186 20.348 1.00 78.74 A C原子91 CD ARG A 50-10.070 11.797 20.900 1.00 79.88 A C原子92 NE ARG A 50-11.260 11.154 21.461 1.00 80.00 A N原子93 CZ ARG A 50-12.308 10.733 20.752 1.00 80.68 A C原子94 NH1 ARG A 50-12.349 10.873 19.428 1.00 80.61 A N原子95 NH2 ARG A 50-13.333 10.179 21.374 1.00 81.57 A N原子96 C ARG A 50-10.534 15.678 18.536 1.00 72.67 A C
原子97 O ARG A 50-10.265 16.420 19.491 1.00 71.57 A O原子98 N PRO A 51-11.597 15.905 17.726 1.00 70.55 A N原子99 CD PRO A 51-11.883 15.203 16.459 1.00 70.53 A C原子100 CA PRO A 51-12.537 17.023 17.896 1.00 68.80 A C原子101 CB PRO A 51-13.516 16.816 16.743 1.00 69.04 A C原子102 CG PRO A 51-12.638 16.249 15.689 1.00 69.83 A C原子103 C PRO A 51-13.239 17.081 19.252 1.00 67.26 A C原子104 O PRO A 51-13.990 16.167 19.616 1.00 68.56 A O原子105 N GLN A 52-12.967 18.156 19.993 1.00 64.23 A N原子106 CA GLN A 52-13.532 18.352 21.327 1.00 62.31 A C原子107 CB GLN A 52-12.443 18.188 22.395 1.00 60.62 A C原子108 CG GLN A 52-11.198 19.044 22.206 1.00 58.43 A C原子109 CD GLN A 52-9.974 18.424 22.855 1.00 56.66 A C原子110 OE1 GLN A 52-9.515 18.882 23.898 1.00 57.67 A O原子111 NE2 GLN A 52-9.443 17.370 22.239 1.00 53.32 A N原子112 C GLN A 52-14.315 19.643 21.557 1.00 61.88 A C原子113 O GLN A 52-14.100 20.652 20.882 1.00 61.74 A O原子114 N GLU A 53-15.203 19.591 22.550 1.00 61.18 A N原子115 CA GLU A 53-16.063 20.708 22.930 1.00 60.09 A C原子116 CB GLU A 53-17.328 20.168 23.628 1.00 61.08 A C原子117 CG GLU A 53-18.446 21.192 23.806 1.00 63.17 A C原子118 CD GLU A 53-19.666 20.636 24.515 1.00 64.14 A C原子119 OE1 GLU A 53-20.564 20.108 23.819 1.00 65.25 A O原子120 OE2 GLU A 53-19.732 20.749 25.761 1.00 62.56 A O原子121 C GLU A 53-15.350 21.750 23.809 1.00 58.28 A C原子122 O GLU A 53-15.037 21.492 24.976 1.00 56.98 A O原子123 N VAL A 54-15.057 22.906 23.210 1.00 57.67 A N原子124 CA VAL A 54-14.405 24.026 23.899 1.00 57.21 A C
原子125 CB VAL A 54-13.072 24.470 23.207 1.00 58.22 A C原子126 CG1 VAL A 54-12.070 23.332 23.224 1.00 58.63 A C原子127 CG2 VAL A 54-13.313 24.950 21.771 1.00 57.09 A C原子128 C VAL A 54-15.359 25.218 24.004 1.00 56.95 A C原子129 O VAL A 54-16.118 25.511 23.069 1.00 58.14 A O原子130 N SER A 55-15.320 25.899 25.144 1.00 55.99 A N原子131 CA SER A 55-16.187 27.046 25.374 1.00 55.55 A C原子132 CB SER A 55-17.336 26.675 26.320 1.00 56.90 A C原子133 OG SER A 55-18.092 25.583 25.820 1.00 57.74 A O原子134 C SER A 55-15.415 28.226 25.936 1.00 55.32 A C原子135 O SER A 55-14.671 28.090 26.916 1.00 53.79 A O原子136 N TYR A 56-15.606 29.382 25.300 1.00 55.27 A N原子137 CA TYR A 56-14.950 30.617 25.704 1.00 54.08 A C原子138 CB TYR A 56-13.908 31.048 24.656 1.00 54.14 A C原子139 CG TYR A 56-14.421 31.304 23.247 1.00 54.07 A C原子140 CD1 TYR A 56-14.316 30.313 22.249 1.00 54.75 A C原子141 CE1 TYR A 56-14.738 30.573 20.907 1.00 55.53 A C原子142 CD2 TYR A 56-14.961 32.561 22.887 1.00 53.38 A C原子143 CE2 TYR A 56-15.386 32.832 21.562 1.00 55.52 A C原子144 CZ TYR A 56-15.271 31.838 20.579 1.00 55.95 A C原子145 OH TYR A 56-15.677 32.127 19.295 1.00 58.36 A O原子146 C TYR A 56-15.918 31.756 26.024 1.00 53.58 A C原子147 O TYR A 56-17.066 31.748 25.575 1.00 53.02 A O原子148 N THR A 57-15.413 32.752 26.751 1.00 53.31 A N原子149 CA THR A 57-16.180 33.932 27.155 1.00 52.73 A C原子150 CB THR A 57-16.763 33.749 28.603 1.00 51.39 A C原子151 OG1 THR A 57-17.672 34.818 28.892 1.00 50.63 A O原子152 CG2 THR A 57-15.654 33.694 29.671 1.00 48.86 A C
原子153 C THR A 57-15.306 35.203 27.059 1.00 53.61 A C原子154 O THR A 57-14.207 35.159 26.500 1.00 52.98 A O原子155 N ASP A 58-15.817 36.319 27.597 1.00 55.26 A N原子156 CA ASP A 58-15.147 37.632 27.630 1.00 56.97 A C原子157 CB ASP A 58-14.107 37.675 28.772 1.00 58.09 A C原子158 CG ASP A 58-14.736 37.567 30.166 1.00 58.68 A C原子159 OD1 ASP A 58-13.976 37.645 31.157 1.00 59.45 A O原子160 OD2 ASP A 58-15.974 37.406 30.283 1.00 59.50 A O原子161 C ASP A 58-14.536 38.073 26.287 1.00 57.52 A C原子162 O ASP A 58-13.385 38.526 26.221 1.00 58.39 A O原子163 N THR A 59-15.328 37.928 25.223 1.00 57.12 A N原子164 CA THR A 59-14.904 38.270 23.870 1.00 55.77 A C原子165 CB THR A 59-15.766 37.544 22.809 1.00 55.17 A C原子166 OG1 THR A 59-15.826 36.152 23.133 1.00 52.98 A O原子167 CG2 THR A 59-15.144 37.663 21.422 1.00 54.68 A C原子168 C THR A 59-14.841 39.778 23.626 1.00 56.17 A C原子169 O THR A 59-15.842 40.496 23.731 1.00 56.02 A O原子170 N LYS A 60-13.620 40.228 23.347 1.00 56.47 A N原子171 CA LYS A 60-13.301 41.627 23.089 1.00 56.73 A C原子172 CB LYS A 60-12.439 42.165 24.241 1.00 58.12 A C原子173 CG LYS A 60-12.392 43.688 24.369 1.00 63.26 A C原子174 CD LYS A 60-11.485 44.158 25.528 1.00 65.77 A C原子175 CE LYS A 60-9.990 44.020 25.214 1.00 66.52 A C原子176 NZ LYS A 60-9.112 44.513 26.320 1.00 68.79 A N原子177 C LYS A 60-12.525 41.669 21.770 1.00 55.70 A C原子178 O LYS A 60-11.749 40.762 21.481 1.00 55.63 A O原子179 N VAL A 61-12.763 42.704 20.966 1.00 54.52 A N原子180 CA VAL A 61-12.092 42.881 19.672 1.00 53.33 A C
原子181 CB VAL A 61-12.954 43.743 18.691 1.00 53.45 A C原子182 CG1 VAL A 61-12.413 43.654 17.260 1.00 51.55 A C原子183 CG2 VAL A 61-14.416 43.337 18.744 1.00 52.75 A C原子184 C VAL A 61-10.775 43.623 19.887 1.00 53.48 A C原子185 O VAL A 61-10.783 44.741 20.414 1.00 53.86 A O原子186 N ILE A 62-9.652 43.018 19.497 1.00 54.12 A N原子187 CA ILE A 62-8.371 43.705 19.657 1.00 54.63 A C原子188 CB ILE A 62-7.289 42.878 20.437 1.00 54.25 A C原子189 CG2 ILE A 62-7.633 42.893 21.944 1.00 55.56 A C原子190 CG1 ILE A 62-7.138 41.461 19.886 1.00 51.93 A C原子191 CD1 ILE A 62-6.152 40.565 20.637 1.00 50.17 A C原子192 C ILE A 62-7.840 44.426 18.414 1.00 55.43 A C原子193 O ILE A 62-6.781 45.061 18.458 1.00 58.47 A O原子194 N GLY A 63-8.614 44.367 17.327 1.00 55.99 A N原子195 CA GLY A 63-8.262 45.082 16.110 1.00 55.34 A C原子196 C GLY A 63-8.092 44.406 14.767 1.00 55.89 A C原子197 O GLY A 63-8.640 43.336 14.484 1.00 55.20 A O原子198 N ASN A 64-7.389 45.159 13.918 1.00 56.64 A N原子199 CA ASN A 64-6.980 44.867 12.533 1.00 58.30 A C原子200 CB ASN A 64-5.703 43.955 12.471 1.00 55.34 A C原子201 CG ASN A 64-5.992 42.452 12.314 1.00 53.59 A C原子202 OU1 ASAN A 64-6.890 41.905 12.951 1.00 52.22 A O原子203 ND2 ASN A 64-5.165 41.773 11.505 1.00 53.43 A N原子204 C ASN A 64-7.982 44.544 11.436 1.00 60.09 A C原子205 O ASN A 64-9.180 44.421 11.674 1.00 60.19 A O原子206 N GLY A 65-7.444 44.459 10.225 1.00 61.52 A N原子207 CA GLY A 65-8.215 44.147 9.045 1.00 63.20 A C原子208 C GLY A 65-7.293 43.869 7.879 1.00 64.73 A C
原子209 O GLY A 65-7.779 43.735 6.744 1.00 66.51 A O原子210 N SER A 66-5.979 43.765 8.162 1.00 63.40 A N原子211 CA SER A 66-4.926 43.483 7.165 1.00 60.59 A C原子212 CB SER A 66-3.598 43.174 7.857 1.00 61.32 A C原子213 OG SER A 66-2.579 42.933 6.898 1.00 58.93 A O原子214 C SER A 66-5.419 42.274 6.401 1.00 59.23 A C原子215 O SER A 66-5.505 42.275 5.176 1.00 59.67 A O原子216 N PHE A 67-5.751 41.262 7.192 1.00 57.91 A N原子217 CA PHE A 67-6.383 40.012 6.802 1.00 57.58 A C原子218 CB PHE A 67-5.677 39.120 5.745 1.00 59.96 A C原子219 CG PHE A 67-4.197 38.992 5.887 1.00 63.34 A C原子220 CD1 PHE A 67-3.342 39.800 5.109 1.00 65.19 A C原子221 CD2 PHE A 67-3.639 38.012 6.722 1.00 64.67 A C原子222 CE1 PHE A 67-1.942 39.634 5.158 1.00 66.64 A C原子223 CE2 PHE A 67-2.244 37.835 6.781 1.00 65.66 A C原子224 CZ PHE A 67-1.395 38.648 5.996 1.00 66.74 A C原子225 C PHE A 67-6.767 39.295 8.079 1.00 54.40 A C原子226 O PHE A 67-5.928 38.982 8.936 1.00 51.54 A O原子227 N GLY A 68-8.082 39.249 8.261 1.00 51.86 A N原子228 CA GLY A 68-8.679 38.643 9.424 1.00 48.19 A C原子229 C GLY A 68-8.901 39.681 10.497 1.00 45.00 A C原子230 O GLY A 68-8.550 40.851 10.348 1.00 44.50 A O原子231 N VAL A 69-9.506 39.233 11.582 1.00 43.46 A N原子232 CA VAL A 69-9.780 40.070 12.730 1.00 42.57 A C原子233 CB VAL A 69-11.272 40.572 12.742 1.00 40.97 A C原子234 CG1 VAL A 69-12.257 39.419 12.607 1.00 39.98 A C原子235 CG2 VAL A 69-11.558 41.394 13.994 1.00 41.42 A C原子236 C VAL A 69-9.409 39.229 13.951 1.00 41.72 A C
原子237 O VAL A 69-9.641 38.016 13.959 1.00 43.43 A O原子238 N VAL A 70-8.732 39.841 14.924 1.00 39.49 A N原子239 CA VAL A 70-8.343 39.112 16.129 1.00 36.66 A C原子240 CB VAL A 70-6.818 39.148 16.373 1.00 34.76 A C原子241 CG1 VAL A 70-6.427 38.248 17.532 1.00 34.59 A C原子242 CG2 VAL A 70-6.095 38.668 15.153 1.00 35.75 A C原子243 C VAL A 70-9.114 39.537 17.376 1.00 36.48 A C原子244 O VAL A 70-9.228 40.724 17.689 1.00 36.60 A O原子245 N TYR A 71-9.635 38.536 18.081 1.00 35.72 A N原子246 CA TYR A 71-10.393 38.744 19.304 1.00 34.83 A C原子247 CB TYR A 71-11.723 37.979 19.252 1.00 33.13 A C原子248 CG TYR A 71-12.676 38.416 18.160 1.00 33.84 A C原子249 CD1 TYR A 71-13.610 39.451 18.387 1.00 30.31 A C原子250 CE1 TYR A 71-14.502 39.866 17.371 1.00 31.89 A C原子251 CD2 TYR A 71-12.656 37.797 16.884 1.00 31.57 A C原子252 CE2 TYR A 71-13.544 38.206 15.860 1.00 31.46 A C原子253 CZ TYR A 71-14.462 39.244 16.110 1.00 32.48 A C原子254 OH TYR A 71-15.294 39.695 15.105 1.00 34.90 A O原子255 C TYR A 71-9.610 38.248 20.506 1.00 35.20 A C原子256 O TYR A 71-8.708 37.423 20.368 1.00 35.34 A O原子257 N GLN A 72-9.934 38.791 21.674 1.00 35.83 A N原子258 CA GLN A 72-9.331 38.362 22.928 1.00 38.84 A C原子259 CB GLN A 72-8.910 39.558 23.782 1.00 39.22 A C原子260 CG GLN A 72-8.210 39.178 25.095 1.00 42.43 A C原子261 CD GLN A 72-8.169 40.317 26.107 1.00 45.69 A C原子262 OE1 GLN A 72-7.740 41.442 25.800 1.00 47.58 A O原子263 NE2 GLN A 72-8.611 40.029 27.324 1.00 45.18 A N原子264 C GLN A 72-10.464 37.623 23.639 1.00 40.58 A C
原子265 O GLN A 72-11.573 38.150 23.745 1.00 40.96 A O原子266 N ALA A 73-10.197 36.406 24.103 1.00 41.34 A N原子267 CA ALA A 73-11.209 35.628 24.814 1.00 42.89 A C原子268 CB ALA A 73-11.998 34.754 23.840 1.00 45.03 A C原子269 C ALA A 73-10.597 34.774 25.912 1.00 42.74 A C原子270 O ALA A 73-9.411 34.463 25.872 1.00 43.66 A O原子271 N LYS A 74-11.423 34.399 26.885 1.00 42.37 A N原子272 CA LYS A 74-10.995 33.573 28.006 1.00 41.79 A C原子273 CB LYS A 74-11.407 34.242 29.325 1.00 40.42 A C原子274 CG LYS A 74-11.217 33.402 30.594 1.00 39.17 A C原子275 CD LYS A 74-11.912 34.062 31.763 1.00 39.48 A C原子276 CE LYS A 74-12.145 33.091 32.893 1.00 39.54 A C原子277 NZ LYS A 74-12.844 33.762 34.026 1.00 40.89 A N原子278 C LYS A 74-11.597 32.172 27.918 1.00 43.34 A C原子279 O LYS A 74-12.821 32.029 27.852 1.00 45.48 A O原子280 N LEU A 75-10.741 31.147 27.918 1.00 43.14 A N原子281 CA LEU A 75-11.194 29.752 27.902 1.00 43.75 A C原子282 CB LEU A 75-10.034 28.786 27.670 1.00 42.46 A C原子283 CG LEU A 75-9.250 28.779 26.366 1.00 42.04 A C原子284 CD1 LEU A 75-8.165 27.728 26.474 1.00 42.68 A C原子285 CD2 LEU A 75-10.143 28.488 25.166 1.00 43.53 A C原子286 C LEU A 75-11.780 29.476 29.288 1.00 45.42 A C原子287 O LEU A 75-11.098 29.664 30.307 1.00 44.91 A O原子288 N CYS A 76-13.051 29.073 29.308 1.00 47.32 A N原子289 CA CYS A 76-13.805 28.782 30.535 1.00 47.32 A C原子290 CB CYS A 76-15.250 28.429 30.182 1.00 46.97 A C原子291 SG CYS A 76-16.185 29.686 29.273 1.00 46.90 A S原子292 C CYS A 76-13.221 27.653 31.383 1.00 48.08 A C
原子293 O CYS A 76-13.314 27.688 32.613 1.00 48.28 A O原子294 N ASP A 77-12.577 26.696 30.713 1.00 48.14 A N原子295 CA ASP A 77-11.970 25.525 31.348 1.00 49.94 A C原子296 CB ASP A 77-11.576 24.488 30.290 1.00 54.40 A C原子297 CG ASP A 77-12.506 24.487 29.092 1.00 59.69 A C原子298 OD1 ASP A 77-12.339 25.375 28.219 1.00 61.78 A O原子299 OD2 ASP A 77-13.401 23.611 29.032 1.00 61.90 A O原子300 C ASP A 77-10.747 25.842 32.204 1.00 49.54 A C原子301 O ASP A 77-10.795 25.716 33.428 1.00 48.70 A O原子302 N SER A 78-9.675 26.294 31.550 1.00 50.53 A N原子303 CA SER A 78-8.402 26.617 32.203 1.00 50.36 A C原子304 CB SER A 78-7.249 26.322 31.244 1.00 49.94 A C原子305 OG SER A 78-7.399 27.036 30.027 1.00 51.20 A O原子306 C SER A 78-8.250 28.027 32.793 1.00 49.87 A C原子307 O SER A 78-7.354 28.263 33.620 1.00 50.40 A O原子308 N GLY A 79-9.116 28.951 32.367 1.00 48.73 A N原子309 CA GLY A 79-9.068 30.328 32.852 1.00 48.45 A C原子310 C GLY A 79-7.931 31.116 32.226 1.00 47.57 A C原子311 O GLY A 79-7.395 32.049 32.827 1.00 47.86 A O原子312 N GLU A 80-7.557 30.704 31.017 1.00 46.60 A N原子313 CA GLU A 80-6.471 31.307 30.261 1.00 46.20 A C原子314 CB GLU A 80-5.650 30.216 29.577 1.00 47.50 A C原子315 CG GLU A 80-4.815 29.359 30.510 1.00 50.27 A C原子316 CD GLU A 804.027 28.301 29.760 1.00 51.79 A C原子317 OE1 GLU A 80-4.584 27.216 29.502 1.00 53.92 A O原子318 OE2 GLU A 80-2.854 28.556 29.416 1.00 52.56 A O原子319 C GLU A 80-6.996 32.248 29.201 1.00 44.99 A C原子320 O GLU A 80-8.135 32.119 28.764 1.00 46.86 A O
原子321 N LEU A 81-6.163 33.200 28.799 1.00 41.73 A N原子322 CA LEU A 81-6.533 34.143 27.755 1.00 39.45 A C原子323 CB LEU A 81-5.961 35.534 28.015 1.00 39.84 A C原子324 CG LEU A 81-6.462 36.330 29.215 1.00 42.15 A C原子325 CD1 LEU A 81-5.616 35.986 30.443 1.00 46.21 A C原子326 CD2 LEU A 81-6.348 37.815 28.920 1.00 43.31 A C原子327 C LEU A 81-5.988 33.604 26.446 1.00 37.86 A C原子328 O LEU A 81-4.876 33.056 26.403 1.00 38.05 A O原子329 N VAL A 82-6.792 33.718 25.393 1.00 34.14 A N原子330 CA VAL A 82-6.416 33.249 24.063 1.00 32.45 A C原子331 CB VAL A 82-7.149 31.940 23.645 1.00 34.24 A C原子332 CG1 VAL A 82-6.535 30.741 24.347 1.00 30.19 A C原子333 CG2 VAL A 82-8.677 32.051 23.877 1.00 33.28 A C原子334 C VAL A 82-6.715 34.295 23.019 1.00 30.95 A C原子335 O VAL A 82-7.424 35.265 23.292 1.00 33.09 A O原子336 N ALA A 83-6.150 34.097 21.832 1.00 29.50 A N原子337 CA ALA A 83-6.367 34.986 20.702 1.00 28.28 A C原子338 CB ALA A 83-5.091 35.561 20.228 1.00 27.06 A C原子339 C ALA A 83-7.019 34.180 19.599 1.00 29.27 A C原子340 O ALA A 83-6.652 33.029 19.356 1.00 28.10 A O原子341 N ILE A 84-8.023 34.781 18.964 1.00 31.89 A N原子342 CA ILE A 84-8.778 34.139 17.889 1.00 33.15 A C原子343 CB ILE A 84-10.306 34.028 18.257 1.00 32.07 A C原子344 CG2 ILE A 84-11.111 33.397 17.097 1.00 31.51 A C原子345 CG1 ILE A 84-10.486 33.192 19.535 1.00 32.39 A C原子346 CDI ILE A 84-11.863 33.275 20.162 1.00 33.33 A C原子347 C ILE A 84-8.617 34.907 16.579 1.00 34.75 A C原子348 O ILE A 84-9.122 36.024 16.447 1.00 34.78 A O
原子349 N LYS A 85-7.916 34.309 15.618 1.00 36.38 A N原子350 CA LYS A 85-7.745 34.947 14.322 1.00 39.35 A C原子351 CB LYS A 85-6.335 34.738 13.773 1.00 36.93 A C原子352 CG LYS A 85-5.972 35.802 12.757 1.00 37.08 A C原子353 CD LYS A 85-4.486 35.972 12.601 1.00 36.30 A C原子354 CE LYS A 85-3.942 34.988 11.601 1.00 39.48 A C原子355 NZ LYS A 85-4.487 35.151 10.216 1.00 37.35 A N原子356 C LYS A 85-8.817 34.410 13.370 1.00 43.60 A C原子357 O LYS A 85-8.708 33.293 12.850 1.00 43.72 A O原子358 N LYS A 86-9.883 35.204 13.226 1.00 47.54 A N原子359 CA LYS A 86-11.041 34.896 12.382 1.00 50.00 A C原子360 CB LYS A 86-12.318 35.495 12.994 1.00 51.56 A C原子361 CG LYS A 86-13.643 35.056 12.367 1.00 53.09 A C原子362 CD LYS A 86-14.824 35.658 13.136 1.00 55.36 A C原子363 CE LYS A 86-16.161 35.050 12.738 1.00 55.87 A C原子364 NZ LYS A 86-17.289 35.650 13.503 1.00 57.01 A N原子365 C LYS A 86-10.793 35.447 10.992 1.00 50.80 A C原子366 O LYS A 86-10.755 36.657 10.785 1.00 50.18 A O原子367 N VAL A 87-10.600 34.532 10.051 1.00 53.53 A N原子368 CA VAL A 87-10.322 34.867 8.662 1.00 54.79 A C原子369 CB VAL A 87-8.840 34.463 8.292 1.00 53.70 A C原子370 CG1 VAL A 87-8.437 33.165 8.984 1.00 54.22 A C原子371 CG2 VAL A 87-8.627 34.340 6.796 1.00 51.64 A C原子372 C VAL A 87-11.367 34.274 7.715 1.00 57.22 A C原子373 O VAL A 87-11.795 33.125 7.872 1.00 57.46 A O原子374 N LEU A 88-11.816 35.105 6.777 1.00 59.24 A N原子375 CA LEU A 88-12.784 34.705 5.762 1.00 61.71 A C原子376 CB LEU A 88-13.593 35.934 5.287 1.00 61.62 A C
原子377 CG LEU A 88-14.676 35.989 4.182 1.00 61.11 A C原子378 CD1 LEU A 88-14.097 36.489 2.868 1.00 60.62 A C原子379 CD2 LEU A 88-15.420 34.671 3.998 1.00 61.26 A C原子380 C LEU A 88-11.983 34.103 4.615 1.00 63.45 A C原子381 O LEU A 88-11.949 32.882 4.453 1.00 62.58 A O原子382 N GLN A 89-11.295 35.002 3.902 1.00 66.52 A N原子383 CA GLN A 89-10.450 34.777 2.721 1.00 69.88 A C原子384 CB GLN A 89-9.000 35.239 2.981 1.00 72.16 A C原子385 CG GLN A 89-8.800 36.541 3.823 1.00 75.25 A C原子386 CD GLN A 89-9.787 37.678 3.538 1.00 76.60 A C原子387 OE1 GLN A 89-9.835 38.227 2.435 1.00 77.91 A O原子388 NE2 GLN A 89-10.565 38.044 4.556 1.00 76.81 A N原子389 C GLN A 89-10.503 33.431 1.981 1.00 71.07 A C原子390 O GLN A 89-9.579 32.608 2.048 1.00 70.30 A O原子391 N ASP A 90-11.647 33.213 1.331 1.00 73.00 A N原子392 CA ASP A 90-11.919 32.017 0.536 1.00 75.16 A C原子393 CB ASP A 90-13.362 31.515 0.785 1.00 75.05 A C原子394 CG ASP A 90-13.676 31.255 2.276 1.00 75.86 A C原子395 OD1 ASP A 90-14.830 31.516 2.687 1.00 76.25 A O原子396 OD2 ASP A 90-12.798 30.780 3.035 1.00 74.74 A O原子397 C ASP A 90-11.748 32.527-0.901 1.00 76.66 A C原子398 O ASP A 90-12.723 32.715-1.643 1.00 77.06 A O原子399 N LYS A 91-10.492 32.805-1.255 1.00 77.91 A N原子400 CA LYS A 91-10.147 33.354-2.564 1.00 79.52 A C原子401 CB LYS A 91-9.440 34.706-2.364 1.00 79.06 A C原子402 CG LYS A 91-9.886 35.805-3.329 1.00 78.84 A C原子403 CD LYS A 91-9.999 37.169-2.644 1.00 78.71 A C原子404 CE LYS A 91-11.320 37.318-1.877 1.00 78.79 A C
原子405 NZ LYS A 91-11.477 38.650-1.222 1.00 77.30 A N原子406 C LYS A 91-9.319 32.420-3.453 1.00 80.43 A C原子407 O LYS A 91-9.050 31.272-3.083 1.00 79.35 A O原子408 N ARG A 92-8.965 32.919-4.644 1.00 82.11 A N原子409 CA ARG A 92-8.172 32.193-5.642 1.00 84.06 A C原子410 CB ARG A 92-8.375 32.799-7.036 1.00 85.93 A C原子411 CG ARG A 92-9.577 32.250-7.814 1.00 88.55 A C原子412 CD ARG A 92-9.386 30.795-8.281 1.00 90.11 A C原子413 NE ARG A 92-8.232 30.623-9.171 1.00 91.97 A N原子414 CZ ARG A 92-8.026 29.569-9.965 1.00 93.33 A C原子415 NH1 ARG A 92-8.897 28.564-10.009 1.00 93.76 A N原子416 NH2 ARG A 92-6.927 29.506-10.705 1.00 92.97 A N原子417 C ARG A 92-6.681 32.133-5.314 1.00 84.45 A C原子418 O ARG A 92-5.932 31.359-5.926 1.00 85.44 A O原子419 N PHE A 93-6.258 32.980-4.375 1.00 84.02 A N原子420 CA PHE A 93-4.875 33.021-3.905 1.00 83.00 A C原子421 CB PHE A 93-4.533 34.400-3.329 1.00 84.31 A C原子422 CG PHE A 93-4.084 35.398-4.357 1.00 86.67 A C原子423 CD1 PHE A 93-2.759 35.374-4.850 1.00 87.56 A C原子424 CD2 PHE A 93-4.975 36.378-4.838 1.00 87.66 A C原子425 CE1 PHE A 93-2.317 36.322-5.821 1.00 88.57 A C原子426 CE2 PHE E 93-4.557 37.338-5.810 1.00 88.84 A C原子427 CZ PHE A 93-3.221 37.308-6.303 1.00 89.04 A C原子428 C PHE A 93-4.710 31.970-2.812 1.00 81.99 A C原子429 O PHE A 93-5.694 31.546-2.187 1.00 82.59 A O原子430 N LYS A 94-3.467 31.551-2.588 1.00 79.57 A N原子431 CA LYS A 94-3.152 30.559-1.560 1.00 76.73 A C原子432 CB LYS A 94-1.801 29.904-1.860 1.00 76.69 A C
原子433 CG LYS A 94-1.675 29.263-3.244 1.00 77.93 A C原子434 CD LYS A 94-2.442 27.946-3.343 1.00 80.11 A C原子435 CE LYS A 94-2.302 27.316-4.724 1.00 80.68 A C原子436 NZ LYS A 94-3.130 26.083-4.867 1.00 80.96 A N原子437 C LYS A 94-3.103 31.233-0.184 1.00 74.12 A C原子438 O LYS A 94-2.766 32.414-0.085 1.00 73.53 A O原子439 N ASN A 95-3.515 30.506 0.853 1.00 71.17 A N原子440 CA ASN A 95-3.478 31.021 2.224 1.00 67.52 A C原子441 CB ASN A 95-4.800 30.757 2.951 1.00 67.06 A C原子442 CG ASN A 95-4.759 31.171 4.421 1.00 67.16 A C原子443 OD1 ASN A 95-4.492 32.330 4.753 1.00 65.03 A O原子444 ND2 ASN A 95-4.984 30.207 5.306 1.00 67.41 A N原子445 C ASN A 95-2.316 30.347 2.957 1.00 64.89 A C原子446 O ASN A 95-1.489 31.029 3.574 1.00 65.50 A O原子447 N ARG A 96-2.307 29.009 2.908 1.00 60.67 A N原子448 CA ARG A 96-1.290 28.122 3.505 1.00 57.24 A C原子449 CB ARG A 96 0.072 28.309 2.817 1.00 59.08 A C原子450 CG ARG A 96 0.128 27.932 1.349 1.00 60.20 A C原子451 CD ARG A 96 1.485 28.300 0.788 1.00 60.74 A C原子452 NE ARG A 96 1.642 27.932-0.618 1.00 62.80 A N原子453 CZ ARG A 96 1.777 28.798-1.620 1.00 62.08 A C原子454 NH1 ARG A 96 1.776 30.110-1.393 1.00 59.80 A N原子455 NH2 ARG A 96 1.950 28.349-2.858 1.00 62.64 A N原子456 C ARG A 96-1.076 28.137 5.022 1.00 53.84 A C原子457 O ARG A 96-0.542 27.175 5.582 1.00 52.27 A O原子458 N GLU A 97-1.512 29.211 5.675 1.00 50.79 A N原子459 CA GLU A 97-1.351 29.410 7.115 1.00 48.93 A C原子460 CB GLU A 97-2.110 30.663 7.559 1.00 47.48 A C
原子461 CG GLU A 97-1.973 30.971 9.038 1.00 48.39 A C原子462 CD GLU A 97-2.501 32.318 9.430 1.00 50.87 A C原子463 OE1 GLU A 97-1.866 32.945 10.301 1.00 53.13 A O原子464 OE2 GLU A 97-3.541 32.756 8.897 1.00 50.53 A O原子465 C GLU A 97-1.694 28.236 8.030 1.00 47.73 A C原子466 O GLU A 97-0.858 27.815 8.829 1.00 48.73 A O原子467 N LEU A 98-2.914 27.721 7.887 1.00 46.72 A N原子468 CA LEU A 98-3.452 26.606 8.672 1.00 43.78 A C原子469 CB LEU A 98-4.792 26.164 8.053 1.00 42.50 A C原子470 CG LEU A 98-5.744 25.073 8.577 1.00 42.22 A C原子471 CD1 LEU A 98-5.392 23.663 8.035 1.00 41.98 A C原子472 CD2 LEU A 98-5.836 25.116 10.091 1.00 40.51 A C原子473 C LEU A 98-2.512 25.411 8.822 1.00 43.82 A C原子474 O LEU A 98-2.161 25.039 9.941 1.00 42.54 A O原子475 N GLN A 99-2.104 24.839 7.688 1.00 43.66 A N原子476 CA GLN A 99-1.232 23.673 7.671 1.00 43.80 A C原子477 CB GLN A 99-1.271 22.996 6.288 1.00 44.98 A C原子478 CG GLN A 99-0.849 23.853 5.083 1.00 47.67 A C原子479 CD GLN A 99 0.506 23.437 4.494 1.00 49.93 A C原子480 OE1 GLN A 99 1.125 24.191 3.736 1.00 50.40 A O原子481 NE2 GLN A 99 0.966 22.233 4.839 1.00 49.29 A.N原子482 C GLN A 99 0.195 23.938 8.158 1.00 43.06 A C原子483 O GLN A 99 0.888 23.021 8.614 1.00 44.55 A O原子484 N ILE A 100 0.601 25.204 8.105 1.00 41.89 A N原子485 CA ILE A 100 1.929 25.627 8.551 1.00 40.86 A C原子486 CB ILE A 100 2.361 26.936 7.832 1.00 40.41 A C原子487 CG2 ILE A 100 3.397 27.737 8.645 1.00 41.53 A C原子488 CG1 ILE A 100 2.874 26.573 6.435 1.00 39.91 A C
原子489 CD1 ILE A 100 3.162 27.750 5.527 1.00 40.69 A C原子490 C ILE A 100 1.973 25.736 10.077 1.00 39.97 A C原子491 O ILE A 100 2.921 25.267 10.691 1.00 39.96 A O原子492 N MET A 101 0.904 26.261 10.676 1.00 39.76 A N原子493 CA MET A 101 1.804 26.415 12.132 1.00 40.67 A C原子494 CB MET A 101-0.372 27.322 12.489 1.00 39.39 A C原子495 CG MET A 101-0.195 28.758 12.023 1.00 38.88 A C原子496 SD MET A 101 0.499 29.851 13.282 1.00 42.14 A S原子497 CE MET A 101-0.668 31.237 13.182 1.00 37.39 A C原子498 C MET A 101 0.698 25.083 12.873 1.00 41.77 A C原子499 MET A 101 1.064 24.993 14.054 1.00 42.55 A O原子500 N ARG A 102 0.253 24.049 12.148 1.00 43.40 A N原子501 CA ARG A 102 0.100 22.682 12.675 1.00 44.45 A C原子502 CB ARG A 102-1.021 21.933 11.938 1.00 45.97 A C原子503 CG ARG A 102-2.422 22.480 12.168 1.00 48.87 A C原子504 CD ARG A 102-3.483 21.662 11.434 1.00 51.77 A C原子505 NE ARG A 102-3.672 20.337 12.029 1.00 55.60 A N原子506 CZ ARG A 102-4.463 19.383 11.540 1.00 57.08 A C原子507 NH1 ARG A 102-5.164 19.582 10.427 1.00 57.90 A N原子508 NH2 ARG A 102-4.580 18.231 12.190 1.00 58.58 A N原子509 C ARG A 102 1.404 21.886 12.551 1.00 42.69 A C原子510 O ARG A 102 1.463 20.715 12.916 1.00 44.06 A O原子511 N LYS A 103 2.431 22.538 12.016 1.00 41.77 A N原子512 CA LYS A 103 3.752 21.942 11.813 1.00 40.65 A C原子513 CB LYS A 103 4.193 22.171 10.350 1.00 42.26 A C原子514 CG LYS A 103 5.438 21.397 9.860 1.00 44.81 A C原子515 CD LYS A 103 5.959 21.932 8.506 1.00 47.46 A C原子516 CE LYS A 103 5.016 21.613 7.324 1.00 50.80 A C
原子517 NZ LYS A 103 5.299 22.401 6.073 1.00 50.60 A N原子518 C LYS A 103 4.755 22.595 12.770 1.00 37.52 A C原子519 O LYS A 103 5.806 22.020 13.062 1.00 37.53 A O原子520 N LEU A 104 4.414 23.784 13.267 1.00 32.67 A N原子521 CA LEU A 104 5.303 24.521 14.154 1.00 30.44 A C原子522 CB LEU A 104 5.313 26.010 13.809 1.00 27.57 A C原子523 CG LEU A 104 5.501 26.420 12.349 1.00 25.33 A C原子524 CD1 LEU A 104 5.358 27.916 12.251 1.00 21.03 A C原子525 CD2 LEU A 104 6.824 25.916 11.743 1.00 21.93 A C原子526 C LEU A 104 5.130 24.357 15.651 1.00 30.04 A C原子527 O LEU A 104 4.025 24.381 16.189 1.00 28.26 A O原子528 N ASP A 105 6.276 24.210 16.304 1.00 32.22 A N原子529 CA ASP A 105 6.379 24.066 17.742 1.00 33.54 A C原子530 CB ASP A 105 6.308 22.586 18.145 1.00 33.42 A C原子531 CG ASP A 105 6.280 22.384 19.648 1.00 32.07 A C原子532 OD1 ASP A 105 6.348 21.212 20.070 1.00 33.96 A O原子533 OD2 ASP A 105 6.199 23.381 20.405 1.00 31.71 A O原子534 C ASP A 105 7.725 24.685 18.143 1.00 34.25 A C原子535 O ASP A 105 8.789 24.081 17.941 1.00 33.37 A O原子536 N HIS A 106 7.648 25.899 18.697 1.00 32.99 A N原子537 CA HIS A 106 8.811 26.662 19.150 1.00 29.56 A C原子538 CB HIS A 106 9.458 27.365 17.962 1.00 29.95 A C原子539 CG HIS A 106 10.858 27.830 18.203 1.00 29.98 A C原子540 CD2 HIS A 106 12.048 27.212 18.002 1.00 28.61 A C原子541 ND1 HIS A 106 11.154 29.110 18.623 1.00 28.32 A N原子542 CE1 HIS A 106 12.467 29.262 18.661 1.00 27.31 A C原子543 NE2 HIS A 106 13.032 28.127 18.289 1.00 27.49 A N原子544 C HIS A 106 8.338 27.697 20.164 1.00 28.43 A C
原子545 O HIS A 106 7.236 28.242 20.052 1.00 24.05 A O原子546 N CYS A 107 9.199 27.970 21.140 1.00 29.61 A N原子547 CA CYS A 107 8.939 28.933 22.208 1.00 30.22 A C原子548 CB CYS A 107 9.987 28.769 23.308 1.00 32.19 A C原子549 SG CYS A 107 11.693 28.878 22.719 1.00 40.81 A S原子550 C CYS A 107 8.899 30.395 21.735 1.00 29.43 A C原子551 O CYS A 107 8.377 31.268 22.442 1.00 30.02 A O原子552 N ASN A 108 9.445 30.656 20.547 1.00 27.53 A N原子553 CA ASN A 108 9.451 32.013 20.002 1.00 26.72 A C原子554 CB ASN A 108 10.872 32.457 19.647 1.00 24.38 A C原子555 CG ASN A 108 11.780 32.521 20.862 1.00 24.81 A C原子556 OD1 ASN A 108 12.949 32.106 20.815 1.00 24.17 A O原子557 ND2 ASN A 108 11.253 33.060 21.958 1.00 21.53 A N原子558 C ASN A 108 8.482 32.236 18.844 1.00 24.85 A C原子559 O ASN A 108 8.624 33.190 18.069 1.00 22.84 A O原子560 N ILE A 109 7.491 31.342 18.754 1.00 22.79 A N原子561 CA ILE A 109 6.427 31.353 17.737 1.00 20.07 A C原子562 CB ILE A 109 6.676 30.280 16.625 1.00 19.83 A C原子563 CG2 ILE A 109 5.471 30.210 15.647 1.00 19.73 A C原子564 CG1 ILE A 109 7.978 30.577 15.862 1.00 16.39 A C原子565 CD1 ILE A 109 8.446 29.497 14.918 1.00 10.51 A C原子566 C ILE A 109 5.142 30.990 18.485 1.00 18.63 A C原子567 O ILE A 109 5.157 30.050 19.279 1.00 18.91 A O原子568 N VAL A 110 4.049 31.726 18.246 1.00 17.94 A N原子569 CA VAL A 110 2.766 31.440 18.910 1.00 21.24 A C原子570 CB VAL A 110 1.617 32.425 18.576 1.00 21.98 A C原子571 CG1 VAL A 110 1.575 33.540 19.555 1.00 21.89 A C原子572 CG2 VAL A 110 1.701 32.918 17.154 1.00 24.93 A C
原子573 C VAL A 110 2.231 30.064 18.601 1.00 21.98 A C原子574 O VAL A 110 2.221 29.628 17.440 1.00 21.41 A O原子575 N ARG A 111 1.817 29.384 19.663 1.00 24.70 A N原子576 CA ARG A 111 1.270 28.039 19.567 1.00 28.73 A C原子577 CB ARG A 111 1.392 27.320 20.919 1.00 29.40 A C原子578 CG ARG A 111 0.849 25.885 20.967 1.00 35.17 A C原子579 CD ARG A 111 0.746 25.343 22.403 1.00 36.48 A C原子580 NE ARG A 111 0.020 26.254 23.289 1.00 36.86 A N原子581 CZ ARG A 111-0.254 26.020 24.571 1.00 38.52 A C原子582 NH1 ARG A 111 0.115 24.881 25.156 1.00 39.27 A N原子583 NH2 ARG A 111-0.823 26.973 25.301 1.00 35.94 A N原子584 C ARG A 111-0.190 28.100 19.132 1.00 29.34 A C原子585 O ARG A 111-0.948 28.971 19.582 1.00 28.48 A O原子586 N LEU A 112-0.528 27.247 18.165 1.00 29.85 A N原子587 CA LEU A 112-1.895 27.118 17.692 1.00 29.70 A C原子588 CB LEU A 112-1.951 26.646 16.233 1.00 31.70 A C原子589 CG LEU A 112-3.352 26.312 15.678 1.00 32.75 A C原子590 CD1 LEU A 112-4.161 27.570 15.464 1.00 33.07 A C原子591 CD2 LEU A 112-3.244 25.526 14.394 1.00 34.44 A C原子592 C LEU A 112-2.512 26.067 18.606 1.00 29.49 A C原子593 O LEU A 112-2.065 24.909 18.639 1.00 27.49 A O原子594 N ARG A 113-3.470 26.511 19.412 1.00 30.42 A N原子595 CA ARG A 113-4.182 25.638 20.335 1.00 32.08 A C原子596 CB ARG A 113-4.991 26.466 21.330 1.00 30.08 A C原子597 CG ARG A 113-4.465 26.536 22.718 1.00 29.02 A C原子598 CD ARG A 113-3.459 27.650 22.895 1.00 29.80 A C原子599 NE ARG A 113-3.721 28.525 24.047 1.00 28.97 A N原子600 CZ ARG A 113-3.775 28.150 25.329 1.00 30.80 A C
原子601 NH1 ARG A 113-3.597 26.880 25.688 1.00 34.69 A N原子602 NH2 ARG A 113-3.959 29.069 26.270 1.00 31.31 A N原子603 C ARG A 113-5.146 24.795 19.518 1.00 34.91 A C原子604 O ARG A 113-4.955 23.590 19.365 1.00 35.85 A O原子605 N TYR A 114-6.144 25.464 18.936 1.00 38.25 A N原子606 CA TYR A 114-7.191 24.808 18.150 1.00 40.77 A C原子607 CB TYR A 114-8.459 24.680 19.004 1.00 40.31 A C原子608 CG TYR A 114-8.336 24.151 20.432 1.00 40.66 A C原子609 CD1 TYR A 114-8.644 24.984 21.530 1.00 40.37 A C原子610 CE1 TYR A 114-8.600 24.496 22.861 1.00 40.52 A C原子611 CD2 TYR A 114-7.972 22.808 20.697 1.00 41.14 A C原子612 CE1 TYR A 114-7.926 22.304 22.035 1.00 39.28 A C原子613 CZ TYR A 114-8.247 23.157 23.101 1.00 40.33 A C原子614 OH TYR A 114-8.269 22.681 24.390 1.00 42.49 A O原子615 C TYR A 114-7.547 25.607 16.892 1.00 41.56 A C原子616 O TYR A 114-6.966 26.656 16.644 1.00 44.00 A O原子617 N PHE A 115-8.509 25.098 16.113 1.00 44.34 A N原子618 CA PHE A 115-9.021 25.742 14.883 1.00 46.13 A C原子619 CB PHE A 115-8.057 25.555 13.684 1.00 45.12 A C原子620 CG PHE A 115-7.852 24.116 13.253 1.00 46.81 A C原子621 CD1 PHE A 115-8.473 23.626 12.085 1.00 49.33 A C原子622 CD2 PHE A 115-7.018 23.252 13.989 1.00 48.46 A C原子623 CE1 PHE A 115-8.265 22.285 11.645 1.00 51.04 A C原子624 CE2 PHE A 115-6.796 21.907 13.565 1.00 50.07 A C原子625 CZ PHE A 115-7.424 21.425 12.389 1.00 49.96 A C原子626 C PHE A 115-10.452 25.270 14.518 1.00 47.83 A C原子627 O PHE A 115-10.666 24.079 14.268 1.00 48.32 A O原子628 N PHE A 116-11.430 26.180 14.536 1.00 48.38 A N
原子629 CA PHE A 116-12.814 25.824 14.192 1.00 48.69 A C原子630 CB PHE A 116-13.727 25.801 15.437 1.00 49.59 A C原子631 CG PHE A 116-13.926 27.148 16.103 1.00 50.11 A C原子632 CD1 PHE A 116-15.070 27.929 15.818 1.00 49.65 A C原子633 CD2 PHE A 116-12.977 27.648 17.007 1.00 48.22 A C原子634 CE1 PHE A 116-15.262 29.191 16.426 1.00 49.16 A C原子635 CE2 PHE A 116-13.158 28.911 17.625 1.00 47.45 A C原子636 CZ PHE A 116-14.301 29.683 17.333 1.00 47.95 A C原子637 C PHE A 116-13.424 26.713 13.120 1.00 50.20 A C原子638 O PHE A 116-13.149 27.913 13.074 1.00 50.64 A O原子639 N TYR A 117-14.306 26.131 12.309 1.00 51.52 A N原子640 CA TYR A 117-14.989 26.873 11.249 1.00 51.88 A C原子641 CB TYR A 117-15.127 26.029 9.977 1.00 46.80 A C原子642 CG TYR A 117-13.832 25.773 9.226 1.00 43.88 A C原子643 CD1 TYR A 117-13.508 26.516 8.071 1.00 40.86 A C原子644 CE1 TYR A 117-12.302 26.265 7.339 1.00 40.26 A C原子645 CD2 TYR A 117-12.928 24.764 9.644 1.00 43.30 A C原子646 CE2 TYR A 117-11.714 24.498 8.913 1.00 40.72 A C原子647 CZ TYR A 117-11.415 25.254 7.766 1.00 39.84 A C原子648 OH TYR A 117-10.253 25.008 7.057 1.00 38.55 A O原子649 C TYR A 117-16.360 27.351 11.735 1.00 54.74 A C原子650 O TYR A 117-17.087 26.616 12.415 1.00 54.00 A O原子651 N SER A 118-16.669 28.610 11.438 1.00 58.47 A N原子652 CA SER A 118-17.939 29.217 11.828 1.00 62.82 A C原子653 CB SER A 118-17.791 29.994 13.155 1.00 63.02 A C原子654 OG SER A 118-17.119 31.237 12.984 1.00 63.23 A O原子655 C SER A 118-18.424 30.138 10.708 1.00 66.42 A C原子656 O SER A 118-17.979 30.019 9.564 1.00 65.62 A O
原子657 N SER A 119-19.345 31.038 11.059 1.00 70.65 A N原子658 CA SER A 119-19.942 32.019 10.151 1.00 74.60 A C原子659 CB SER A 119-21.015 31.365 9.262 1.00 74.93 A C原子660 OG SER A 119-21.936 30.596 10.022 1.00 74.84 A O原子661 C SER A 119-20.567 33.132 10.987 1.00 77.54 A C原子662 0 SER A 119-20.497 34.318 10.629 1.00 77.18 A O原子663 N GLY A 120-21.142 32.722 12.120 1.00 80.95 A N原子664 CA GLY A 120-21.806 33.631 13.037 1.00 84.13 A C原子665 C GLY A 120-23.299 33.645 12.766 1.00 86.64 A C原子666 O GLY A 120-24.085 33.094 13.547 1.00 86.23 A O原子667 N GLU A 121-23.682 34.306 11.667 1.00 89.00 A N原子668 CA GLU A 121-25.084 34.417 11.247 1.00 91.11 A C原子669 CB GLU A 121-25.785 35.642 11.900 1.00 92.07 A C原子670 CG GLU A 121-24.926 36.910 12.161 1.00 92.86 A C原子671 CD GLU A 121-24.330 36.983 13.579 1.00 93.33 A C原子672 OE1 GLU A 121-24.759 36.217 14.474 1.00 93.37 A O原子673 OE2 GLU A 121-23.425 37.819 13.798 1.00 93.27 A O原子674 C GLU A 121-25.381 34.325 9.726 1.00 91.77 A C原子675 O GLU A 121-25.375 33.222 9.167 1.00 91.66 A O原子676 N LYS A 122-25.596 35.471 9.067 1.00 92.61 A N原子677 CA LYS A 122-25.949 35.554 7.632 1.00 92.88 A C原子678 CB LYS A 122-26.536 36.957 7.325 1.00 93.33 A C原子679 CG LYS A 122-27.247 37.150 5.957 1.00 92.18 A C原子680 CD LYS A 122-28.544 36.342 5.810 1.00 91.50 A C原子681 CE LYS A 122-28.621 35.577 4.493 1.00 90.99 A C原子682 NZ LYS A 122-28.303 36.419 3.309 1.00 90.55 A N原子683 C LYS A 122-24.907 35.152 6.564 1.00 92.49 A C原子684 O LYS A 122-23.691 35.208 6.788 1.00 93.08 A O
原子685 N LYS A 123-25.449 34.736 5.411 1.00 91.41 A N原子686 CA LYS A 123-24.756 34.289 4.194 1.00 90.02 A C原子687 CB LYS A 123-24.005 35.443 3.498 1.00 90.40 A C原子688 CG LYS A 123-24.902 36.538 2.900 1.00 91.10 A C原子689 CD LYS A 123-24.792 36.668 1.368 1.00 91.44 A C原子690 CE LYS A 123-25.672 35.669 0.595 1.00 90.62 A C原子691 NZ LYS A 123-27.131 35.835 0.860 1.00 89.82 A N原子692 C LYS A 123-23.896 33.028 4.271 1.00 89.07 A C原子693 O LYS A 123-23.618 32.504 5.357 1.00 88.53 A O原子694 N ASP A 124-23.509 32.539 3.091 1.00 88.23 A N原子695 CA ASP A 124-22.692 31.333 2.933 1.00 86.86 A C原子696 CB ASP A 124-22.607 30.927 1.448 1.00 86.94 A C原子697 CG ASP A 124-21.833 31.931 0.596 1.00 87.24 A C原子698 OD1 ASP A 124-20.759 31.557 0.079 1.00 87.84 A O原子699 OD2 ASP A 124-22.287 33.089 0.459 1.00 87.92 A O原子700 C ASP A 124-21.285 31.443 3.522 1.00 85.10 A C原子701 O ASP A 124-20.703 30.425 3.911 1.00 86.04 A O原子702 N GLU A 125-20.779 32.682 3.606 1.00 82.22 A N原子703 CA GLU A 125-19.438 33.004 4.120 1.00 78.05 A C原子704 CB GLU A 125-19.229 34.536 4.209 1.00 77.65 A C原子705 CG GLU A 125-20.398 35.366 4.773 1.00 78.10 A C原子706 CD GLU A 125-20.204 36.887 4.671 1.00 77.56 A C原子707 OE1 GLU A 125-19.356 37.358 3.875 1.00 74.79 A O原子708 OE2 GLU A 125-20.923 37.618 5.392 1.00 76.86 A O原子709 C GLU A 125-19.011 32.281 5.406 1.00 75.44 A C原子710 O GLU A 125-19.420 32.631 6.518 1.00 74.62 A O原子711 N VAL A 126-18.283 31.183 5.193 1.00 72.75 A N原子712 CA VAL A 126-17.757 30.328 6.257 1.00 69.40 A C
原子713 CB VAL A 126-17.751 28.805 5.821 1.00 70.96 A C原子714 CG1 VAL A 126-17.055 28.606 4.474 1.00 71.90 A C原子715 CG2 VAL A 126-17.129 27.910 6.902 1.00 72.54 A C原子716 C VAL A 126-16.384 30.851 6.705 1.00 65.08 A C原子717 O VAL A 126-15.436 30.929 5.914 1.00 64.86 A O原子718 N TYR A 127-16.320 31.259 7.969 1.00 60.73 A N原子719 CA TYR A 127-15.104 31.825 8.557 1.00 56.58 A C原子720 CB TYR A 127-15.482 32.953 9.535 1.00 56.20 A C原子721 CG TYR A 127-16.057 34.225 8.900 1.00 56.66 A C原子722 CD1 TYR A 127-17.387 34.272 8.425 1.00 55.45 A C原子723 CE1 TYR A 127-17.931 35.457 7.842 1.00 55.12 A C原子724 CD2 TYR A 127-15.274 35.394 8.782 1.00 56.70 A C原子725 CE2 TYR A 127-15.804 36.588 8.198 1.00 58.25 A C原子726 CZ TYR A 127-17.133 36.607 7.730 1.00 57.71 A C原子727 OH TYR A 127-17.639 37.754 7.146 1.00 56.53 A O原子728 C TYR A 127-14.202 30.802 9.256 1.00 52.61 A C原子729 O TYR A 127-14.685 29.931 9.982 1.00 51.15 A O原子730 N LEU A 128-12.901 30.880 8.967 1.00 48.55 A N原子731 CA LEU A 128-11.879 30.017 9.578 1.00 43.88 A C原子732 CB LEU A 128-10.715 29.778 8.590 1.00 42.20 A C原子733 CG LEU A 128-9.326 29.263 9.034 1.00 41.94 A C原子734 CD1 LEU A 128-9.379 27.864 9.661 1.00 43.16 A C原子735 CD2 LEU A 128-8.384 29.271 7.839 1.00 42.29 A C原子736 C LEU A 128-11.378 30.747 10.835 1.00 40.19 A C原子737 O LEU A 128-10.876 31.865 10.744 1.00 40.68 A O原子738 N ASN A 129-11.561 30.133 11.999 1.00 36.45 A N原子739 CA ASN A 129-11.128 30.737 13.264 1.00 33.88 A C原子740 CB ASN A 129-12.284 30.800 14.279 1.00 34.37 A C
原子741 CG ASN A 129-13.540 31.462 13.730 1.00 33.33 A C原子742 OD1 ASN A 129-14.113 31.008 12.743 1.00 36.35 A O原子743 ND2 ASN A 129-13.997 32.513 14.401 1.00 31.97 A N原子744 C ASN A 129-9.988 29.933 13.886 1.00 32.07 A C原子745 O ASN A 129-10.192 28.784 14.262 1.00 31.07 A O原子746 N LEU A 130-8.807 30.550 14.003 1.00 30.70 A N原子747 CA LEU A 130-7.612 29.919 14.591 1.00 28.47 A C原子748 CB LEU A 130-6.357 30.359 13.832 1.00 34 A C原子749 CG LEU A 130-6.222 30.069 12.336 1.00 28.51 A C原子750 CD1 LEU A 130-5.310 31.097 11.683 1.00 26.00 A C原子751 CD2 LEU A 130-5.701 28.652 12.102 1.00 26.67 A C原子752 C LEU A 130-7.456 30.327 16.060 1.00 27.86 A C原子753 O LEU A 130-7.238 31.506 16.340 1.00 27.53 A O原子754 N VAL A 131-7.598 29.377 16.994 1.00 26.68 A N原子755 CA VAL A 131-7.442 29.676 18.429 1.00 28.08 A C原子756 CB VAL A 131-8.322 28.767 19.332 1.00 30.39 A C原子757 CG1 VAL A 131-8.053 29.035 20.820 1.00 30.65 A C原子758 CG2 VAL A 131-9.779 29.016 19.046 1.00 28.27 A C原子759 C VAL A 131-5.964 29.544 18.789 1.00 27.17 A C原子760 O VAL A 131-5.391 28.458 18.695 1.00 25.59 A O原子761 N LEU A 132-5.361 30.688 19.135 1.00 27.45 A N原子762 CA LEU A 132-3.933 30.813 19.467 1.00 26.12 A C原子763 CB LEU A 132-3.270 31.732 18.442 1.00 26.03 A C原子764 CG LEU A 132-3.165 31.271 16.986 1.00 28.47 A C原子765 CD1 LEU A 132-3.688 32.363 16.046 1.00 27.02 A C原子766 CD2 LEU A 132-1.714 30.905 16.673 1.00 26.94 A C原子767 C LEU A 132-3.607 31.346 20.870 1.00 25.75 A C原子768 O LEU A 132-4.465 31.889 21.572 1.00 22.73 A O
原子769 N ASP A 133-2.33831.21821.2521.00 26.31 A N原子770 CA ASP A 133-1.858 31.699 22.543 1.00 27.99 A C原子771 CB ASP A 133-0.458 31.171 22.806 1.00 31.88 A C原子772 CG ASP A 133-0.461 29.915 23.626 1.00 33.68 A C原子773 OD1 ASP A 133-1.154 29.866 24.664 1.00 36.12 A O原子774 OD2 ASP A 133 0.249 28.978 23.242 1.00 38.19 A O原子775 C ASP A 133-1.832 33.222 22.606 1.00 29.00 A C原子776 O ASP A 133-1.386 33.870 21.648 1.00 29.34 A O原子777 N TYR A 134-2.373 33.785 23.692 1.00 26.69 A N原子778 CA TYR A 134-2.388 35.234 23.864 1.00 25.43 A C原子779 CB TYR A 134-3.553 35.690 24.738 1.00 22.57 A C原子780 CG TYR A 134-3.639 37.185 25.015 1.00 21.80 A C原子781 CD1 TYR A 134-4.096 38.088 24.024 1.00 18.90 A C原子782 CE1 TYR A 134-4.171 39.504 24.292 1.00 18.04 A C原子783 CD2 TYR A 134-3.256 37.710 26.284 1.00 18.73 A C原子784 CE2 TYR A 134-3.325 39.108 26.561 1.00 15.99 A C原子785 CZ TYR A 134-3.782 40.001 25.564 1.00 18.68 A C原子786 OH TYR A 134-3.849 41.366 25.842 1.00 18.13 A O原子787 C TYR A 134-1.071 35.691 24.466 1.00 26.26 A C原子788 O TYR A 134-0.468 35.001 25.303 1.00 26.61 A O原子789 N VAL A 135-0.613 36.834 23.958 1.00 24.85 A N原子790 CA VAL A 135 0.627 37.480 24.379 1.00 25.09 A C原子791 CB VAL A 135 1.742 37.334 23.308 1.00 22.94 A C原子792 CG1 VAL A 135 3.063 37.620 23.923 1.00 23.51 A C原子793 CG2 VAL A 135 1.790 35.923 22.733 1.00 17.58 A C原子794 C VAL A 135 0.168 38.934 24.544 1.00 25.50 A C原子795 O VAL A 135-0.421 39.496 23.630 1.00 26.56 A O原子796 N PRO A 136 0.429 39.560 25.706 1.00 23.87 A N
原子797 CD PRO A 136 0.978 38.981 26.948 1.00 24.88 A C原子798 CA PRO A 136-0.018 40.948 25.924 1.00 24.35 A C原子799 CB PRO A 136 0.213 41.166 27.428 1.00 24.03 A C原子800 CG PRO A 136 1.283 40.191 27.766 1.00 25.67 A C原子801 C PRO A 136 0.388 42.156 25.085 1.00 24.04 A C原子802 O PRO A 136-0.406 43.093 24.958 1.00 26.03 A O原子803 N GLU A 137 1.591 42.149 24.509 1.00 22.49 A N原子804 CA GLU A 137 2.067 43.289 23.718 1.00 19.62 A C原子805 CB GLU A 137 3.058 44.122 24.558 1.00 18.33 A C原子806 CG GLU A 137 2.425 45.059 25.602 1.00 15.10 A C原子807 CD GLU A 137 1.498 46.124 25.005 1.00 18.86 A C原子808 OE1 GLU A 137 1.565 46.408 23.784 1.00 17.56 A O原子809 OE2 GLU A 137 0.682 46.683 25.767 1.00 24.07 A O原子810 C GLU A 137 2.710 42.929 22.385 1.00 17.50 A C原子811 O GLU A 137 2.721 41.775 22.008 1.00 17.40 A O原子812 N THR A 138 3.129 43.942 21.628 1.00 16.15 A N原子813 CA THR A 138 3.833 43.749 20.357 1.00 17.07 A C原子814 CB THR A 138 3.008 44.179 19.091 1.00 15.32 A C原子815 OG1 THR A 138 2.722 45.579 19.132 1.00 11.52 A O原子816 CG2 THR A 138 1.720 43.401 18.957 1.00 14.61 A C原子817 C THR A 138 5.089 44.624 20.425 1.00 18.97 A C原子818 O THR A 138 5.144 45.562 21.237 1.00 20.86 A O原子819 N VAL A 139 6.085 44.339 19.577 1.00 18.95 A N原子820 CA VAL A 139 7.323 45.137 19.537 1.00 19.72 A C原子821 CB VAL A 139 8.433 44.487 18.626 1.00 17.86 A C原子822 CG1 VAL A 139 9.514 45.459 18.256 1.00 16.24 A C原子823 CG2 VAL A 139 9.102 43.356 19.347 1.00 17.17 A C原子824 C VAL A 139 6.979 46.559 19.100 1.00 20.98 A C
原子825 O VAL A 139 7.462 47.501 19.702 1.00 21.50 A O原子826 N TYR A 140 6.076 46.693 18.123 1.00 22.72 A N原子827 CA TYR A 140 5.643 47.993 17.621 1.00 25.95 A C原子828 CB TYR A 140 4.598 47.829 16.509 1.00 31.87 A C原子829 CG TYR A 140 4.061 49.135 15.945 1.00 33.87 A C原子830 CD1 TYR A 140 4.865 49.953 15.122 1.00 35.27 A C原子831 CE1 TYR A 140 4.387 51.193 14.633 1.00 39.03 A C原子832 CD2 TYR A 140 2.759 49.579 16.267 1.00 34.43 A C原子833 CE2 TYR A 140 2.267 50.819 15.786 1.00 38.29 A C原子834 CZ TYR A 140 3.089 51.620 14.970 1.00 40.12 A C原子835 OH TYR A 140 2.624 52.835 14.507 1.00 44.26 A O原子836 C TYR A 140 5.067 48.830 18.758 1.00 27.09 A C原子837 O TYR A 140 5.524 49.942 18.983 1.00 26.72 A O原子838 N ARG A 141 4.096 48.273 19.483 1.00 27.22 A N原子839 CA ARG A 141 3.476 48.969 20.608 1.00 26.45 A C原子840 CB ARG A 141 2.332 48.150 21.202 1.00 26.63 A C原子841 CG ARG A 141 1.052 48.172 20.351 1.00 29.13 A C原子842 CD ARG A 141-0.143 47.607 21.102 1.00 27.11 A C原子843 NE ARG A 141-0.324 48.279 22.384 1.00 30.83 A N原子844 CZ ARG A 141-1.207 47.932 23.317 1.00 34.02 A C原子845 NH1 ARG A 141-2.047 46.912 23.121 1.00 38.45 A N原子846 NH2 ARG A 141-1.134 48.498 24.516 1.00 32.23 A N原子847 C ARG A 141 4.481 49.365 21.691 1.00 25.66 A C原子848 O ARG A 141 4.444 50.505 22.174 1.00 26.13 A O原子849 N VAL A 142 5.435 48.472 21.983 1.00 24.01 A N原子850 CA VAL A 142 6.464 48.749 22.993 1.00 23.59 A C原子851 CB VAL A 142 7.088 47.443 23.572 1.00 22.50 A C原子852 CG1 VAL A 142 8.353 47.729 24.375 1.00 19.27 A C
原子853 CG2 VAL A 142 6.070 46.751 24.510 1.00 20.12 A C原子854 C VAL A 142 7.518 49.729 22.471 1.00 24.65 A C原子855 O VAL A 142 7.950 50.620 23.203 1.00 26.20 A O原子856 N ALA A 143 7.852 49.618 21.187 1.00 25.08 A N原子857 CA ALA A 143 8.821 50.507 20.555 1.00 25.54 A C原子858 CB ALA A 143 9.251 49.950 19.207 1.00 23.86 A C原子859 C ALA A 143 8.222 51.907 20.392 1.00 26.54 A C原子860 O ALA A 143 8.943 52.895 20.474 1.00 28.74 A O原子861 N ARG A 144 6.895 51.967 20.251 1.00 27.36 A N原子862 CA ARG A 144 6.131 53.214 20.087 1.00 29.98 A C原子863 CB ARG A 144 4.740 52.898 19.527 1.00 32.69 A C原子864 CG ARG A 144 3.905 54.063 19.032 1.00 34.14 A C原子865 CD ARG A 144 2.459 53.721 19.281 1.00 37.19 A C原子866 NE ARG A 144 1.596 54.000 18.139 1.00 40.63 A N原子867 CZ ARG A 144 0.365 53.506 17.999 1.00 41.79 A C原子868 NH1 ARG A 144-0.152 52.702 18.929 1.00 40.02 A N原子869 NH2 ARG A 144-0.356 53.826 16.931 1.00 42.14 A N原子870 C ARG A 144 5.984 53.946 21.416 1.00 29.28 A C原子871 O ARG A 144 5.937 55.169 21.440 1.00 29.55 A O原子872 N HIS A 145 5.914 53.186 22.509 1.00 29.56 A N原子873 CA HIS A 145 5.798 53.740 23.860 1.00 29.77 A C原子874 CB HIS A 145 5.558 52.610 24.876 1.00 31.77 A C原子875 CG HIS A 145 5.591 53.053 26.309 1.00 36.22 A C原子876 CD2 HIS A 145 4.673 53.699 27.066 1.00 37.45 A C原子877 ND1 HIS A 145 6.679 52.833 27.130 1.00 38.32 A N原子878 CE1 HIS A 145 6.427 53.321 28.331 1.00 37.02 A C原子879 NE2 HIS A 145 5.218 53.853 28.319 1.00 38.72 A N原子880 C HIS A 145 7.055 54.556 24.214 1.00 28.01 A C
原子881 O HIS A 145 6.944 55.712 24.647 1.00 26.93 A O原子882 N TYR A 146 8.228 53.953 23.993 1.00 26.45 A N原子883 CA TYR A 146 9.519 54.606 24.249 1.00 26.53 A C原子884 CB TYR A 146 10.692 53.618 24.124 1.00 23.97 A C原子885 CG TYR A 146 10.885 52.742 25.347 1.00 20.61 A C原子886 CD1 TYR A 146 10.296 51.462 25.416 1.00 18.00 A C原子887 CE1 TYR A 146 10.433 50.642 26.579 1.00 17.99 A C原子888 CD2 TYR A 146 11.626 53.200 26.464 1.00 19.40 A C原子889 CE2 TYR A 146 11.774 52.390 27.643 1.00 18.16 A C原子890 CZ TYR A 146 11.174 51.111 27.683 1.00 19.24 A C原子891 OH TYR A 146 11.336 50.285 28.779 1.00 19.81 A O原子892 C TYR A 146 9.742 55.806 23.326 1.00 26.54 A C原子893 O TYR A 146 10.155 56.859 23.801 1.00 26.81 A O原子894 N SER A 147 9.379 55.665 22.046 1.00 25.86 A N原子895 CA SERA 147 9.524 56.721 21.037 1.00 27.77 A C原子896 CB SERA 147 9.154 56.186 19.649 1.00 28.75 A C原子897 OG SERA 147 9.378 57.153 18.624 1.00 29.72 A O原子898 C SER A 147 8.706 57.987 21.343 1.00 30.68 A C原子899 O SER A 147 9.248 59.100 21.308 1.00 29.28 A O原子900 N ARG A 148 7.425 57.800 21.685 1.00 32.90 A N原子901 CA ARG A 148 6.514 58.899 22.022 1.00 34.64 A C原子902 CB ARG A 148 5.070 58.390 22.170 1.00 37.64 A C原子903 CG ARG A 148 4.430 57.992 20.843 1.00 41.36 A C原子904 CD ARG A 148 2.907 57.986 20.870 1.00 44.26 A C原子905 NE ARG A 148 2.363 58.283 19.536 1.00 48.03 A N原子906 CZ ARG A 148 1.348 57.643 18.946 1.00 49.42 A C原子907 NH1 ARG A 148 0.718 56.642 19.558 1.00 47.68 A N原子908 NH2 ARG A 148 0.982 57.987 17.712 1.00 48.98 A N
原子909 C ARG A 148 6.963 59.648 23.287 1.00 35.38 A C原子910 O ARG A 148 6.604 60.818 23.493 1.00 33.18 A O原子911 N ALA A 149 7.811 58.980 24.076 1.00 35.64 A N原子912 CA ALA A 149 8.374 59.524 25.313 1.00 36.33 A C原子913 CB ALA A 149 8.280 58.492 26.429 1.00 35.66 A C原子914 C ALA A 149 9.825 59.966 25.100 1.00 37.03 A C原子915 O ALA A 149 10.628 60.005 26.046 1.00 37.12 A O原子916 N LYS A 150 10.142 60.293 23.840 1.00 37.06 A N原子917 CA LYS A 150 11.466 60.746 23.389 1.00 37.94 A C原子918 CB LYS A 150 11.648 62.251 23.649 1.00 39.56 A C原子919 CG LYS A 150 10.960 63.145 22.617 1.00 43.00 A C原子920 CD LYS A 150 11.681 63.111 21.260 1.00 44.89 A C原子921 CE LYS A 150 11.089 64.114 20.276 1.00 46.47 A C原子922 NZ LYS A 150 11.909 64.230 19.033 1.00 47.00 A N原子923 C LYS A 150 12.655 59.930 23.898 1.00 36.49 A C原子924 O LYS A 150 13.723 60.465 24.200 1.00 36.82 A O原子925 N GLN A 151 12.439 58.620 23.969 1.00 34.84 A N原子926 CA GLN A 151 13.445 57.677 24.428 1.00 33.37 A C原子927 CB GLN A 151 13.080 57.127 25.812 1.00 34.05 A C原子928 CG GLN A 151 14.226 379 26.501 1.00 38.78 A C原子929 CD GLN A 151 13.912 55.938 27.920 1.00 41.78 A C原子930 OE1 GLN A 151 12.977 56.451 28.562 1.00 39.31 A O原子931 NE2 GLN A 151 14.717 54.989 28.432 1.00 41.05 A N原子932 C GLN A 151 13.587 56.548 23.426 1.00 30.24 A C原子933 O GLN A 151 12.746 56.363 22.552 1.00 29.98 A O原子934 N THR A 152 14.712 55.852 23.521 1.00 28.74 A N原子935 CA THR A 152 15.015 54.724 22.662 1.00 24.49 A C原子936 CB THR A 152 16.443 54.914 22.018 1.00 24.37 A C
原子937 OG1 THR A 152 16.336 54.858 20.588 1.00 23.47 A O原子938 CG2 THR A 152 17.470 53.891 22.498 1.00 26.16 A C原子939 C THR A 152 14.880 53.494 23.552 1.00 21.94 A C原子940 O THR A 152 15.094 53.579 24.766 1.00 23.32 A O原子941 N LEU A 153 14.452 52.382 22.964 1.00 19.61 A N原子942 CA LEU A 153 14.298 51.112 23.676 1.00 18.67 A C原子943 CB LEU A 153 13.728 50.067 22.713 1.00 18.78 A C原子944 CG LEU A 153 13.448 48.636 23.183 1.00 20.73 A C原子945 CD1 LEU A 153 12.109 48.558 23.919 1.00 17.83 A C原子946 CD2 LEU A 153 13.457 47.684 21.996 1.00 16.10 A C原子947 C LEU A 153 15.701 50.698 24.136 1.00 18.65 A C原子948 0 LEU A 153 16.615 50.697 23.323 1.00 20.94 A O原子949 N PRO A 154 15.907 50.435 25.451 1.00 19.11 A N原子950 CD PRO A 154 14.962 50.594 26.575 1.00 20.76 A C原子951 CA PRO A 154 17.225 50.035 25.967 1.00 19.35 A C原子952 CB PRO A 154 16.938 49.692 27.427 1.00 18.17 A C原子953 CG PRO A 154 15.897 50.685 27.778 1.00 19.29 A C原子954 C PRO A 154 17.803 48.858 25.217 1.00 19.91 A C原子955 O PRO A 154 17.102 47.882 24.964 1.00 21.15 A O原子956 N VAL A 155 19.066 49.006 24.820 1.00 19.62 A N原子957 CA VAL A 155 19.825 48.016 24.054 1.00 20.67 A C原子958 CB VAL A 155 21.327 48.406 23.976 1.00 21.91 A C原子959 CG1 VAL A 155 22.064 47.530 23.001 1.00 23.46 A C原子960 CG2 VAL A 155 21.456 49.832 23.491 1.00 25.92 A C原子961 C VAL A 155 19.662 46.548 24.470 1.00 18.71 A C原子962 O VAL A 155 19.642 45.664 23.604 1.00 20.28 A O原子963 N ILE A 156 19.453 46.303 25.764 1.00 15.16 A N原子964 CA ILE A 156 19.269 44.941 26.271 1.00 13.81 A C
原子965 CB ILE A 156 19.382 44.893 27.827 1.00 11.15 A C原子966 CG2 ILE A 156 18.336 45.789 28.479 1.00 10.21 A C原子967 CG1 ILE A 156 19.280 43.455 28.367 1.00 13.17 A C原子968 CD1 ILE A 156 20.459 42.576 28.076 1.00 9.54 A C原子969 C ILE A 156 17.957 44.301 25.747 1.00 15.23 A C原子970 O ILE A 156 17.911 43.097 25.530 1.00 16.61 A O原子971 N TYR A 157 16.933 45.117 25.489 1.00 13.61 A N原子972 CA TYR A 157 15.666 44.614 24.960 1.00 12.61 A C原子973 CB TYR A 157 14.494 45.556 25.266 1.00 11.76 A C原子974 CG TYR A 157 14.086 45.630 26.730 1.00 12.85 A C原子975 CD1 TYR A 157 14.149 46.854 27.434 1.00 15.71 A C原子976 CE1 TYR A 157 13.763 46.954 28.803 1.00 12.18 A C原子977 CD2 TYR A 157 13.631 44.491 27.422 1.00 13.30 A C原子978 CE2 TYR A 157 13.247 44.567 28.791 1.00 16.53 A C原子979 CZ TYR A 157 13.316 45.808 29.470 1.00 16.06 A C原子980 OH TYR A 157 12.941 45.896 30.792 1.00 14.94 A O原子981 C TYR A 157 15.811 44.409 23.464 1.00 13.12 A C原子982 O TYR A 157 15.285 43.443 22.920 1.00 13.91 A O原子983 N VAL A 158 16.591 45.277 22.816 1.00 15.26 A N原子984 CA VAL A 158 16.862 45.178 21.372 1.00 15.53 A C原子985 CB VAL A 158 17.785 46.344 20.846 1.00 15.48 A C原子986 CG1 VAL A 158 18.104 46.172 19.378 1.00 15.22 A C原子987 CG2 VAL A 158 17.134 47.675 21.053 1.00 12.99 A C原子988 C VAL A 158 17.575 43.850 21.159 1.00 14.83 A C原子989 O VAL A 158 17.206 43.111 20.267 1.00 20.37 A O原子990 N LYS A 159 18.537 43.535 22.032 1.00 14.37 A N原子991 CA LYS A 159 19.300 42.287 21.975 1.00 14.73 A C原子992 CB LYS A 1259 20.398 42.264 23.052 1.00 17.05 A C
原子993 CG LYS A 159 21.623 43.117 22.768 1.00 17.71 A C原子994 CD LYS A 159 22.621 43.103 23.921 1.00 17.41 A C原子995 CE LYS A 159 23.670 44.169 23.734 1.00 13.09 A C原子996 NZ LYS A 159 24.918 43.895 24.487 1.00 16.53 A N原子997 C LYS A 159 18.392 41.074 22.172 1.00 14.07 A C原子998 O LYS A 159 18.422 40.143 21.395 1.00 14.83 A O原子999 N LEU A 160 17.564 41.122 23.206 1.00 13.93 A N原子1000 CA LEU A 160 16.639 40.056 23.532 1.00 16.72 A C原子1001 CB LEU A 160 15.909 40.397 24.816 1.00 15.82 A C原子1002 CG LEU A 160 16.687 40.134 26.087 1.00 17.14 A C原子1003 CD1 LEU A 160 16.029 40.935 27.164 1.00 16.63 A C原子1004 CD2 LEU A 160 16.740 38.631 26.421 1.00 19.20 A C原子1005 C LU A 160 15.603 39.749 22.467 1.00 18.54 A C原子1006 O LEU A 160 15.426 38.589 22.075 1.00 18.28 A O原子1007 N TYR A 161 14.960 40.810 21.979 1.00 19.35 A N原子1008 CA TYR A 161 13.897 40.709 20.982 1.00 18.69 A C原子1009 CB TYR A 161 13.194 42.066 20.828 1.00 19.53 A C原子1010 CG TYR A 161 12.579 42.636 22.107 1.00 20.40 A C原子1011 CD1 TYR A 161 12.482 41.859 23.297 1.00 19.87 A C原子1012 CE1 TYR A 161 11.893 42.378 24.473 1.00 21.10 A C原子1013 CD2 TYR A 161 12.071 43.957 22.132 1.00 19.09 A C原子1014 CE2 TYR A 161 11.469 44.494 23.308 1.00 18.79 A C原子1015 CZ TYR A 161 11.381 43.692 24.470 1.00 22.26 A C原子1016 OH TYR A 161 10.744 44.166 25.601 1.00 25.56 A O原子1017 C TYR A 161 14.401 40.212 19.646 1.00 18.80 A C原子1018 O TYR A 161 13.825 39.287 19.065 1.00 19.39 A O原子1019 N MET A 162 15.546 40.753 19.237 1.00 18.46 A N原子1020 CA MET A 162 16.193 40.407 17.980 1.00 20.35 A C
原子1021 CB MET A 162 17.262 41.455 17.670 1.00 24.61 A C原子1022 CG MET A 162 17.379 41.846 16.200 1.00 29.46 A C原子1023 SD MET A 162 15.867 42.505 15.463 1.00 27.23 A S原子1024 CE MET A 162 15.445 43.669 16.614 1.00 26.70 A C原子1025 C MET A 162 16.788 38.998 17.941 1.00 19.88 A C原子1026 O MET A 162 16.828 38.371 16.879 1.00 20.15 A O原子1027 N TYR A 163 17.220 38.503 19.101 1.00 17.08 A N原子1028 CA TYR A 163 17.778 37.159 19.231 1.00 18.01 A C原子1029 CB YR AW 163 18.469 37.033 20.592 1.00 15.14 A C原子1030 CG TYR A 163 19.065 35.686 20.899 1.00 15.15 A C原子1031 CD1 TYR A 163 20.331 35.320 20.412 1.00 14.59 A C原子1032 CE1 TYR A 163 20.871 34.038 20.697 1.00 14.78 A C原子1033 CD2 TYR A 163 18.354 34.755 21.674 1.00 14.93 A C原子1034 CE2 TYR A 163 18.875 33.494 21.953 1.00 16.91 A C原子1035 CZ TYR A 163 20.128 33.135 21.468 1.00 16.54 A C原子1036 OH TYR A 163 20.609 31.875 21.767 1.00 22.13 A O原子1037 C TYR A 163 16.668 36.092 19.083 1.00 19.83 A C原子1038 O TYR A 163 16.870 35.054 18.439 1.00 19.39 A O原子1039 N GLN A 164 15.523 36.349 19.713 1.00 18.29 A N原子1040 CA GLN A 164 14.388 35.439 19.671 1.00 18.68 A C原子1041 CB GLN A 164 13.383 35.803 20.754 1.00 17.81 A C原子1042 CG GLN A 164 13.928 35.581 22.144 1.00 16.73 A C原子1043 CD GLN A 164 13.025 36.114 23.218 1.00 18.60 A C原子1044 OE1 GLN A 164 12.420 35.346 23.955 1.00 20.73 A O原子1045 NE2 GLN A 164 12.953 37.441 23.343 1.00 19.75 A N原子1046 C GLN A 164 13.736 35.427 18.296 1.00 22.63 A C原子1047 O GLN A 164 13.118 34.425 17.898 1.00 23.42 A O原子1048 N LEU A 165 13.915 36.527 17.557 1.00 22.82 A N
原子1049 CA LEU A 165 13.390 36.643 16.199 1.00 22.39 A C原子1050 CB LEU A 165 13.472 38.080 15.692 1.00 22.76 A C原子1051 CG LEU A 165 12.505 38.662 14.659 1.00 20.98 A C原子1052 CD1 LEU A 165 13.272 39.678 13.891 1.00 21.25 A C原子1053 CD2 LEU A 165 11.873 37.654 13.696 1.00 26.60 A C原子1054 C LEU A 165 14.258 35.765 15.309 1.00 20.30 A C原子1055 O LEU A 165 13.741 34.973 14.539 1.00 21.43 A O原子1056 N PHE A 166 15.574 35.887 15.459 1.00 20.09 A N原子1057 CA PHE A 166 16.526 35.098 14.676 1.00 19.88 A C原子1058 CB PHE A 166 17.942 35.644 14.818 1.00 16.41 A C原子1059 CG PHE A 166 18.185 36.904 14.043 1.00 17.58 A C原子1060 CD1 PHE A 166 18.813 38.001 14.653 1.00 18.19 A C原子1061 CD2 PHE A 166 17.804 37.001 12.687 1.00 19.26 A C原子1062 CE1 PHE A 166 19.063 39.186 13.932 1.00 18.03 A C原子1063 CE2 PHE A 166 18.044 38.175 11.947 1.00 17.78 A C原子1064 CZ PHE A 166 18.675 39.274 12.569 1.00 19.13 A C原子1065 C PHE A 166 16.492 33.625 15.025 1.00 19.72 A C原子1066 O PHE A 166 16.838 32.787 14.195 1.00 23.09 A O原子1067 N ARG A 167 16.053 33.317 16.244 1.00 19.37 A N原子1068 CA ARG A 167 15.921 31.935 16.707 1.00 20.74 A C原子1069 CB ARG A 167 15.828 31.896 18.238 1.00 19.95 A C原子1070 CG ARG A 167 16.119 30.563 18.869 1.00 21.19 A C原子1071 CD ARG A 167 16.701 30.719 20.274 1.00 23.38 A C原子1072 NE ARG A 167 15.908 30.076 21.329 1.00 27.21 A N原子1073 CZ ARG A 167 15.771 28.761 21.500 1.00 27.17 A C原子1074 NH1 ARG A 167 16.369 27.893 20.695 1.00 24.83 A N原子1075 NH2 ARG A 167 15.003 28.310 22.471 1.00 29.82 A N原子1076 C ARG A 167 14.658 31.358 16.038 1.00 21.01 A C
原子1077 O ARG A 167 14.716 30.282 15.438 1.00 21.84 A O原子1078 N SER A 168 13.579 32.155 16.023 1.00 21.52 A N原子1079 CA SER A 168 12.294 31.780 15.408 1.00 22.69 A C原子1080 CB SER A 168 11.204 32.812 15.730 1.00 24.69 A C原子1081 OG SER A 168 11.412 34.045 15.053 1.00 24.23 A O原子1082 C SER A 168 12.432 31.655 13.892 1.00 21.63 A C原子1083 O SER A 168 11.736 30.852 13.257 1.00 20.43 A O原子1084 N LEU A 169 13.329 32.455 13.322 1.00 19.92 A N原子1085 CA LEU A 169 13.562 32.401 11.889 1.00 22.34 A C原子1086 CB LEU A 169 14.154 33.708 11.353 1.00 19.42 A C原子1087 CG LEU A 169 13.297 34.983 11.235 1.00 17.78 A C原子1088 CD1 LEU A 169 14.139 36.091 10.586 1.00 17.05 A C原子1089 CD2 LEU A 169 12.016 34.746 10.444 1.00 14.48 A C原子1090 C LEU A 169 14.418 31.188 11.501 1.00 24.54 A C原子1091 O LEU A 169 14.162 30.562 10.472 1.00 22.76 A O原子1092 N ALA A 170 15.337 30.793 12.391 1.00 24.89 A N原子1093 CA ALA A 170 16.229 29.646 12.176 1.00 23.84 A C原子1094 CB ALA A 170 17.245 29.564 13.306 1.00 21.64 A C原子1095 C ALA A 170 15.443 28.355 12.093 1.00 25.42 A C原子1096 O ALA A 170 15.707 27.502 11.243 1.00 26.20 A O原子1097 N TYR A 171 14.430 28.273 12.949 1.00 27.33 A N原子1098 CA TYR A 171 13.543 27.127 13.048 1.00 27.49 A C原子1099 CB TYR A 171 12.646 27.279 14.290 1.00 25.45 A C原子1100 CG TYR A 171 11.590 26.196 14.487 1.00 25.00 A C原子1101 CD1 TYR A 171 11.941 24.901 14.918 1.00 22.50 A C原子1102 CE1 TYR A 171 10.948 23.900 15.106 1.00 24.34 A C原子1103 CD2 TYR A 171 10.232 26.471 14.249 1.00 24.77 A C原子1104 CE2 TYR A 171 9.234 25.486 14.433 1.00 25.75 A C
原子1105 CZ TYR A 171 9.594 24.208 14.861 1.00 25.96 A C原子1106 OH TYR A 171 8.606 23.263 15.053 1.00 27.53 A O原子1107 C TYR A 171 12.708 26.923 11.787 1.00 27.67 A C原子1108 O TYR A 171 12.676 25.815 11.254 1.00 29.21 A O原子1109 N ILE A 172 12.020 27.976 11.337 1.00 28.82 A N原子1110 CA ILE A 172 11.177 27.879 10.145 1.00 28.16 A C原子1111 CB ILE A 172 10.137 29.048 10.005 1.00 27.47 A C原子1112 CG2 ILE A 172 9.108 28.982 11.128 1.00 25.75 A C原子1113 CG1 ILE A 172 10.815 30.415 9.930 1.00 24.37 A C原子1114 CD1 ILE A 172 9.906 31.537 9.480 1.00 22.33 A C原子1115 C ILE A 172 11.988 27.709 8.863 1.00 29.06 A C原子1116 O ILE A 172 11.593 26.945 7.985 1.00 29.17 A O原子1117 N HIS A 173 13.157 28.350 8.801 1.00 29.31 A N原子1118 CA HIS A 173 14.028 28.246 7.635 1.00 29.89 A C原子1119 CB HIS A 173 15.149 29.285 7.674 1.00 26.91 A C原子1120 CG HIS A 173 14.687 30.689 7.440 1.00 27.24 A C原子1121 CD2 HIS A 173 13.444 31.219 7.326 1.00 25.67 A C原子1122 ND1 HIS A 173 15.565 31.748 7.348 1.00 26.72 A N原子1123 CE1 HIS A 173 14.882 32.870 7.198 1.00 26.23 A C原子1124 NE2 HIS A 173 13.593 32.577 7.181 1.00 27.18 A N原子1125 C HIS A 173 14.616 26.845 7.499 1.00 32.53 A C原子1126 O HIS A 173 14.881 26.405 6.379 1.00 37.00 A O原子1127 N SER A 174 14.755 26.133 8.625 1.00 32.07 A N原子1128 CA SER A 174 15.288 24.765 8.632 1.00 33.69 A C原子1129 CB SER A 174 15.741 24.355 10.036 1.00 32.18 A C原子1130 OG SER A 174 14.653 24.093 10.907 1.00 28.45 A O原子1131 C SER A 174 14.242 23.784 8.096 1.00 35.80 A C原子1132 O SER A 174 14.562 22.651 7.718 1.00 37.14 A O
原子1133 N PHE A 175 12.990 24.241 8.110 1.00 37.64 A N原子1134 CA PHE A 175 11.841 23.499 7.598 1.00 40.20 A C原子1135 CB PHE A 175 10.613 23,782 8.464 1.00 44.61 A C原子1136 CG PHE A 175 10.319 22.726 9.489 1.00 47.63 A C原子1137 CD1 PHE A 175 10.362 23.038 10.861 1.00 48.58 A C原子1138 CD2 PHE A 175 9.923 21.429 9.092 1.00 47.83 A C原子1139 CE1 PHE A 175 10.005 22.068 11.843 1.00 51.84 A C原子1140 CE2 PHE A 175 9.563 20.444 10.051 1.00 50.25 A C原子1141 CZ PHE A 175 9.601 20.762 11.434 1.00 51.82 A C原子1142 C PHE A 175 11.569 23.978 6.160 1.00 40.39 A C原子1143 O PHE A 175 10.633 23.501 5.497 1.00 39.81 A O原子1144 N GLY A 176 12.381 24.949 5.716 1.00 39.69 A N原子1145 CA GLY A 176 12.278 25.529 4.383 1.00 36.62 A C原子1146 C GLY A 176 11.225 26.613 4.231 1.00 34.33 A C原子1147 O GLY A 176 11.041 27.132 3.127 1.00 33.92 A O原子1148 N ILE A 177 10.580 26.978 5.343 1.00 31.96 A N原子1149 CA ILE A 177 9.505 27.984 5.382 1.00 31.27 A C原子1150 CB ILE A 177 8.463 27.656 6.513 1.00 30.38 A C原子1151 CG2 ILE A 177 7.300 28.673 6.504 1.00 31.04 A C原子1152 CG1 ILE A 177 7.929 26.223 6.340 1.00 30.32 A C原子1153 CD1 ILE 1A 177 6.897 25.766 7.374 1.00 28.01 A C原子1154 C ILE A 177 9.968 29.447 5.528 1.00 30.13 A C原子1155 O ILE A 177 10.794 29.776 6.380 1.00 28.36 A O原子1156 N CYS A 178 9.358 30.313 4.721 1.00 28.94 A N原子1157 CA CYS A 178 9.644 31.738 4.716 1.00 29.00 A C原子1158 CB CYS A 178 10.069 32.167 3.326 1.00 28.54 A C原子1159 SG CYS A 178 10.722 33.811 3.220 1.00 31.05 A S原子1160 C CYS A 178 8.390 32.497 5.142 1.00 29.43 A C
原子1161 O CYS A 178 7.344 32.411 4.482 1.00 28.90 A O原子1162 N HIS A 179 8.518 33.257 6.232 1.00 26.83 A N原子1163 CA HIS A 179 7.418 34.032 6.805 1.00 25.43 A C原子1164 CB HIS A 179 7.888 34.674 8.116 1.00 24.10 A C原子1165 CG HIS A 179 6.798 35.333 8.894 1.00 21.36 A C原子1166 CD2 HIS A 179 5.978 34.854 9.858 1.00 20.67 A C原子1167 ND1 HIS A 179 6.451 36.655 8.712 1.00 21.07 A N原子1168 CE1 HIS A 179 5.461 36.959 9.537 1.00 22.86 A C原子1169 NE2 HIS A 179 5.156 35.885 10.242 1.00 19.76 A N原子1170 C HIS A 179 6.830 35.082 5.841 1.00 24.76 A C原子1171 O HIS A 179 5.602 35.225 5.746 1.00 23.83 A O原子1172 N ARG A 180 7.719 35.787 5.137 1.00 21.70 A N原子1173 CA ARG A 180 7.378 36.810 4.138 1.00 25.08 A C原子1174 CB ARG A 180 6.667 36.193 2.901 1.00 24.27 A C原子1175 CG ARG A 180 7.432 35.074 2.187 1.00 26.19 A C原子1176 CD ARG A 180 6.831 34.712 0.844 1.00 27.56 A C原子1177 NE ARG A 180 5.398 34.423 0.929 1.00 30.48 A N原子1178 CZ ARG A 180 4.607 34.166-0.115 1.00 31.58 A C原子1179 NH1 ARG A 180 5.092 34.151-1.354 1.00 27.82 A N原子1180 NH2 ARG A 180 3.320 33.897 0.090 1.00 31.74 A N原子1181 C ARG A 180 6.628 38.074 4.588 1.00 25.17 A C原子1182 O ARG A 180 6.015 38.738 3.758 1.00 27.79 A O原子1183 N ASP A 181 6.627 38.366 5.890 1.00 25.38 A N原子1184 CA ASP A 181 5.991 39.572 6.444 1.00 21.79 A C原子1185 CB ASP A 181 4.458 39.458 6.480 1.00 21.64 A C原子1186 CG ASP A 181 3.770 40.826 6.567 1.00 20.59 A C原子1187 OD1 ASP A 181 4.442 41.856 6.364 1.00 21.96 A O原子1188 OD2 ASP A 181 2.562 40.878 6.850 1.00 24.24 A O
原子1189 C ASP A 181 6.544 39.929 7.838 1.00 21.31 A C原子1190 O ASP A 181 5.797 40.262 8.764 1.00 22.46 A O原子1191 N ILE A 182 7.863 39.879 7.970 1.00 19.49 A N原子1192 CA ILE A 182 8.526 40.204 9.222 1.00 20.02 A C原子1193 CB ILE A 182 9.977 39.632 9.246 1.00 19.38 A C原子1194 CG2 ILE A 182 10.810 40.226 10.395 1.00 18.82 A C原子1195 CG1 ILE A 182 9.948 38.096 9.232 1.00 16.75 A C原子1196 CD1 ILE A 182 9.299 37.457 10.437 1.00 13.80 A C原子1197 C ILE A 182 8.505 41.716 9.399 1.00 20.65 A C原子1198 O ILE A 182 8.992 42.464 8.554 1.00 20.96 A O原子1199 N LYS A 183 7.821 42.131 10.461 1.00 21.97 A N原子1200 CA LYS A 183 7.650 43.527 10.845 1.00 21.58 A C原子1201 CB LYS A 183 6.480 44.151 10.056 1.00 22.46 A C原子1202 CG LYS A 183 5.149 43.433 10.113 1.00 27.57 A C原子1203 CD LYS A 183 4.075 44.307 9.496 1.00 31.15 A C原子1204 CE LYS A 183 2.746 43.586 9.330 1.00 30.47 A C原子1205 NZ LYS A 183 1.770 44.446 8.604 1.00 31.06 A N原子1206 C LYS A 183 7.355 43.530 12.355 1.00 20.88 A C原子1207 O LYS A 183 6.914 42.514 12.875 1.00 21.10 A O原子1208 N PRO A 184 7.603 44.655 13.078 1.00 20.98 A N原子1209 CD PRO A 184 8.340 45.863 12.662 1.00 19.71 A C原子1210 CA PRO A 184 7.341 44.730 14.522 1.00 20.53 A C原子1211 CB PRO A 184 7.777 46.141 14.862 1.00 20.46 A C原子1212 CG PRO A 184 8.898 46.362 13.945 1.00 19.75 A C原子1213 C PRO A 184 5.904 44.459 14.981 1.00 22.58 A C原子1214 O PRO A 184 5.680 44.101 16.146 1.00 25.06 A O原子1215 N GLN A 185 4.947 44.593 14.063 1.00 21.33 A N原子1216 CA GLN A 185 3.530 44.361 14.355 1.00 22.67 A C
原子1217 CB GLN A 185 2.646 44.962 13.252 1.00 23.73 A C原子1218 CG GLN A 185 2.597 46.518 13.186 1.00 26.60 A C原子1219 CD GLN A 185 3.798 47.196 12.484 1.00 28.80 A C原子1220 OE1 GLN A 185 4.778 46.551 12.079 1.00 27.47 A O原子1221 NE2 GLN A 185 3.702 48.518 12.330 1.00 30.26 A N原子1222 C GLN A 185 3.245 42.865 14.517 1.00 22.34 A C原子1223 O GLN A 185 2.318 42.461 15.221 1.00 22.90 A O原子1224 N ASN A 186 4.102 42.055 13.906 1.00 22.13 A N原子1225 CA ASN A 186 3.993 40.605 13.963 1.00 20.93 A C原子1226 CB ASN A 186 4.219 40.017 12.575 1.00 19.79 A C原子1227 CG ASN A 186 3.119 40.374 11.610 1.00 21.23 A C原子1228 OD1 ASN A 186 2.051 40.866 12.007 1.00 21.92 A O原子1229 ND2 ASN A 186 3.369 40.134 10.322 1.00 21.11 A N原子1230 C ASN A 186 4.932 39.959 14.982 1.00 20.81 A C原子1231 O ASN A 186 5.052 38.726 15.035 1.00 22.28 A O原子1232 N LEU A 187 5.616 40.789 15.769 1.00 18.81 A N原子1233 CA LEU A 187 6.524 40.299 16.813 1.00 19.18 A C原子1234 CB LEU A 187 7.908 40.948 16.701 1.00 16.59 A C原子1235 CG LEU A 187 8.615 41.088 15.367 1.00 16.91 A C原子1236 CD1 LEU A 187 9.949 41.762 15.593 1.00 13.39 A C原子1237 CD2 LEU A 187 8.770 39.755 14.672 1.00 19.53 A C原子1238 C LEU A 187 5.90940.597 18.181 1.00 17.56 A C原子1239 O LEU A 187 6.103 41.672 18.745 1.00 17.89 A O原子1240 N LEU A 188 5.143 39.638 18.685 1.00 19.82 A N原子1241 CA LEU A 188 4.447 39.733 19.971 1.00 20.71 A C原子1242 CB LEU A 188 3.428 38.617 20.073 1.00 20.11 A C原子1243 CG LEU A 188 2.426 38.443 18.940 1.00 20.95 A C原子1244 CD1 LEU A 188 1.693 37.143 19.168 1.0022.75 A C
原子1245 CD2 LEU A 188 1.449 39.598 18.855 1.00 17.53 A C原子1246 C LEU A 188 5.378 39.663 21.173 1.00 22.99 A C原子1247 O LEU A 188 6.374 38.946 21.139 1.00 23.79 A O原子1248 N LEU A 189 5.036 40.396 22.231 1.00 24.53 A N原子1249 CA LEU A 189 5.842 40.473 23.452 1.00 28.04 A C原子1250 CB LEU A 189 6.522 41.824 23.558 1.00 32.40 A C原子1251 CG LEU A 189 7.599 42.320 22.638 1.00 37.51 A C原子1252 CD1 LEU A 189 7.960 43.673 23.166 1.00 39.70 A C原子1253 CD2 LEU A 189 8.805 41.393 22.614 1.00 41.58 A C原子1254 C LEU A 189 5.130 40.342 24.784 1.00 28.18 A C原子1255 O LEU A 189 4.013 40.829 24.962 1.00 27.14 A O原子1256 N ASP A 190 5.847 39.756 25.739 1.00 28.19 A N原子1257 CA ASP A 190 5.382 39.627 27.108 1.00 28.55 A C原子1258 CB ASP A 190 5.500 38.178 27.592 1.00 28.74 A C原子1259 CG ASP A 190 4.860 37.961 28.957 1.00 28.01 A C原子1260 OD1 ASP A 190 5.303 38.605 29.926 1.00 26.72 A O原子1261 OD2 ASP A 190 3.913 37.150 29.061 1.00 30.00 A O原子1262 C ASP A 190 6.371 40.569 27.837 1.00 27.97 A C原子1263 O ASP A 190 7.548 40.245 27.955 1.00 27.40 A O原子1264 N PRO A 191 5.910 41.766 28.279 1.00 29.41 A N原子1265 CD PRO A 191 4.504 42.212 28.204 1.00 29.28 A C原子1266 CA PRO A 191 6.705 42.788 28.980 1.00 30.33 A C原子1267 CB PRO A 191 5.653 43.813 29.403 1.00 31.04 A C原子1268 CG PRO A 191 4.637 43.694 28.370 1.00 30.48 A C原子1269 C PRO A 191 7.485 42.341 30.205 1.00 31.91 A C原子1270 O PRO A 191 8.620 42.784 30.413 1.00 34.32 A O原子1271 N ASP A 192 6.878 41.463 31.001 1.00 31.32 A N原子1272 CA ASP A 192 7.498 40.979 32.224 1.00 33.48 A C
原子1273 CB ASP A 192 6.457 40.322 33.140 1.00 37.68 A C原子1274 CG ASP A 192 5.354 41.286 33.587 1.00 41.32 A C原子1275 OD1 ASP A 192 5.573 42.525 33.582 1.00 41.23 A O原子1276 OD2 ASP A 192 4.257 40.790 33.943 1.00 41.76 A O原子1277 C ASP A 192 8.649 40.017 31.997 1.00 33.36 A C原子1278 O ASP A 192 9.733 40.220 32.546 1.00 33.73 A O原子1279 N THR A 193 8.427 39.021 31.138 1.00 31.42 A N原子1280 CA THR A 193 9.424 37.990 30.853 1.00 30.79 A C原子1281 CB THR A 193 8.765 36.628 30.655 1.00 29.36 A C原子1282 OG1 THR A 193 7.864 36.703 29.549 1.00 33.26 A O原子1283 CG2 THR A 193 8.010 36.200 31.899 1.00 29.96 A C原子1284 C THR A 193 10.368 38.210 29.672 1.00 30.22 A C原子1285 O THR A 193 11.349 37.471 29.528 1.00 30.58 A O原子1286 N ALA A 194 10.074 39.211 28.838 1.00 26.81 A N原子1287 CA ALA A 194 10.863 39.533 27.639 1.00 25.60 A C原子1288 CB ALA A 194 12.331 39.863 27.999 1.00 26.36 A C原子1289 C ALA A 194 10.786 38.463 26.530 1.00 24.26 A C原子1290 O ALA A 194 11.630 38.414 25.626 1.00 22.45 A O原子1291 N VAL A 195 9.750 37.626 26.604 1.00 22.33 A N原子1292 CA VAL A 195 9.500 36.577 25.622 1.00 22.37 A C原子1293 CB VAL A 195 8.528 35.485 26.190 1.00 24.64 A C原子1294 CG1 VAL A 195 8.078 34.508 25.095 1.00 21.02 A C原子1295 CG2 VAL A 195&APOS；9.211 34.693 27.308 1.00 25.69 A C原子1296 C VAL A 195 8.891 37.176 24.348 1.00 22.61 A C原子1297 O VAL A 195 7.910 37.946 24.411 1.00 21.55 A O原子1298 N LEU A 196 9.505 36.847 23.210 1.00 20.27 A N原子1299 CA LEU A 196 9.016 37.297 21.911 1.00 20.16 A C原子1300 CB LEU A 196 10.126 37.925 21.050 1.00 20.66 A C
原子1301 CG LEU A 196 9.721 38.503 19.669 1.00 22.78 A C原子1302 CD1 LEU A 196 10.422 39.815 19.404 1.00 19.39 A C原子1303 CD2 LEU A 196 10.005 37.517 18.528 1.00 23.32 A C原子1304 C LEU A 196 8.412 36.097 21.205 1.00 18.39 A C原子1305 O LEU A 196 8.975 35.008 21.246 1.00 19.06 A O原子1306 N LYS A 197 7.245 36.300 20.598 1.00 18.23 A N原子1307 CA LYS A 197 6.543 35.249 19.853 1.00 17.32 A C原子1308 CB LYS A 197 5.261 34.812 20.568 1.00 18.32 A C原子1309 CG LYS A 197 5.463 34.234 21.960 1.00 18.93 A C原子1310 CD LYS A 197 5.298 32.745 22.007 1.00 23.31 A C原子1311 CE LYS A 197 5333 32.225 23.444 1.0024.38 A C原子1312 NZ LYS A 197 4.270 32.858 24.285 1.00 24.87 A N原子1313 C LYS A 197 6.222 35.774 18.454 1.00 17.16 A C原子1314 O LYS A 197 5.679 36.872 18.304 1.00 16.49 A O原子1315 N LEU A 198 6.627 35.025 17.432 1.00 16.38 A N原子1316 CA LEU A 198 6.383 35.409 16.039 1.00 17.74 A C原子1317 CB LEU A 198 7.323 34.650 15.093 1.00 19.56 A C原子1318 CG LEU A 198 8.010 35.358 13.912 1.00 21.82 A C原子1319 CD1 LEU A 198 8.542 34.287 12.960 1.00 18.92 A C原子1320 CD2 LEU A 198 7.093 36.334 13.157 1.00 20.47 A C原子1321 C LEU A 198 4.952 35.033 15.687 1.00 16.43 A C原子1322 O LEU A 198 4.493 33.962 16.061 1.00 17.30 A O原子1323 N CYS A 199 4.251 35.916 14.984 1.00 15.15 A N原子1324 CA CYS A 199 2.886 35.618 14.590 1.00 16.52 A C原子1325 CB CYS A 199 1.900 36.237 15.569 1.00 14.37 A C原子1326 SG CYS A 199 1.711 37.992 15.453 1.00 14.21 A S原子1327 C CYS A 199 2.554 36.010 13.157 1.00 17.24 A C原子1328 O CYS A 199 3.418 36.509 12.443 1.00 17.85 A O
原子1329 N ASP A 200 1.298 35.761 12.764 1.00 18.31 A N原子1330 CA ASP A 200 0.723 36.052 11.440 1.00 20.20 A C原子1331 CB ASP A 200 0.616 37.563 11.174 1.00 21.20 A C原子1332 CG ASP A 200-0.371 37.911 10.039 1.00 26.31 A C原子1333 OD1 ASP A 200-0.665 39.116 9.871 1.00 28.42 A O原子1334 OD2 ASP A 200-0.858 37.002 9.323 1.00 23.86 A O原子1335 C ASP A 200 1.441 35.356 10.295 1.00 22.53 A C原子1336 O ASP A 200 2.300 35.940 9.629 1.00 23.49 A O原子1337 N PHE A 201 1.026 34.124 10.035 1.00 23.42 A N原子1338 CA PHE A 201 1.620 33.336 8.977 1.00 25.50 A C原子1339 CB PHE A 201 1.911 31.919 9.481 1.00 24.98 A C原子1340 CG PHE A 201 3.043 31.850 10.454 1.00 22.19 A C原子1341 CD1 PHE A 201 2.842 32.168 11.808 1.00 23.18 A C原子1342 CD2 PHE A 201 4.329 31.500 10.021 1.00 22.96 A C原子1343 CE1 PHE A 201 3.910 32.145 12.723 1.00 21.08 A C原子1344 CE2 PHE A 201 5.416 31.469 10.923 1.00 22.15 A C原子1345 CZ PHE A 201 5.207 31.795 12.279 1.00 21.37 A C原子1346 C PHE A 201 0.763 33.317 7.711 1.00 26.58 A C原子1347 O PHE A 201 1.016 32.523 6.786 1.00 28.36 A O原子1348 N GLY A 202-0.204 34.234 7.645 1.00 24.70 A N原子1349 CA GLY A 202-1.096 34.331 6.495 1.00 25.81 A C原子1350 C GLY A 202-0.432 34.616 5.155 1.00 27.13 A C原子1351 O GLY A 202-1.096 34.562 4.114 1.00 28.89 A O原子1352 N SER A 203 0.872 34.908 5.194 1.00 27.63 A N原子1353 CA SER A 203 1.681 35.191 4.010 1.00 28.84 A C原子1354 CB SER A 203 2.285 36.611 4.085 1.00 31.91 A C原子1355 OG SER A 203 1.340 37.600 4.458 1.00 35.26 A O原子1356 C SER A 203 2.827 34.171 3.904 1.00 29.78 A C
原子1357 O SER A 203 3.680 34.280 3.011 1.00 30.08 A O原子1358 N ALA A 204 2.860 33.195 4.816 1.00 30.20 A N原子1359 CA ALA A 204 3.916 32.170 4.823 1.00 30.42 A C原子1360 CB ALA A 204 3.978 31.473 6.156 1.00 27.81 A C原子1361 C ALA A 204 3.793 31.152 3.703 1.00 32.11 A C原子1362 O ALA A 204 2.690 30.718 3.356 1.00 34.10 A O原子1363 N LYS A 205 4.941 30.789 3.145 1.00 34.28 A N原子1364 CA LYS A 205 5.026 29.840 2.045 1.00 36.42 A C原子1365 CB LYS A 205 5.113 30.598 0.713 1.00 38.04 A C原子1366 CG LYS A 205 5.085 29.738-0.544 1.00 40.33 A C原子1367 CD LYS A 205 5.628 30.491-1.735 1.00 41.67 A C原子1368 CE LYS A 205 4.786 30.303-3.000 1.00 44.03 A C原子1369 NZ LYS A 205 4.628 28.902-3.454 1.00 45.07 A N原子1370 C LYS A 205 6.269 28.986 2.203 1.00 37.24 A C原子1371 O LYS A 205 7.310 29.472 2.653 1.00 36.33 A O原子1372 N GLN A 206 6.158 27.724 1.788 1.00 39.70 A N原子1373 CA GLN A 206 7.272 26.781 1.839 1.00 42.41 A C原子1374 CB GLN A 206 6.749 25.344 1.969 1.00 42.64 A C原子1375 CG GLN A 206 7.628 24.408 2.796 1.00 47.15 A C原子1376 CD GLN A 206 8.627 23.604 1.971 1.00 49.24 A C原子1377 OE1 GLN A 206 9.714 24.087 1.648 1.00 50.26 A O原子1378 NE2 GLN A 206 8.270 22.357 1.655 1.00 48.19 A N原子1379 C GLN A 206 7.999 26.986 0.516 1.00 42.01 A C原子1380 O GLN A 206 7.461 26.663-0.543 1.00 45.02 A O原子1381 N LEU 207 9.153 27.645 0.571 1.00 40.97 A N原子1382 CA LEU A 207 9.940 27.904-0.628 1.00 41.31 A C原子1383 CB LEU A 207 10.917 29.054-0.433 1.00 40.06 A C原子1384 CG LEU A 207 10.445 30.442-0.016 1.00 40.01 A C
原子1385 CD1 LEU A 207 11.651 31.358-0.067 1.00 41.28 A C原子1386 CD2 LEU A 207 9.347 30.990-0.883 1.00 36.64 A C原子1387 C LEU A 207 10.716 26.686-1.082 1.00 43.20 A C原子1388 O LEU A 207 11.447 26.057-0.306 1.00 42.97 A O原子1389 N VAL A 208 10.506 26.344-2.345 1.00 45.35 A N原子1390 CA VAL A 208 11.167 25.218-2.981 1.00 48.65 A C原子1391 CB VAL A 208 10.177 24.002-3.192 1.00 48.43 A C原子1392 CG1 VAL A 208 8.771 24.484-3.540 1.00 47.91 A C原子1393 CG2 VAL A 208 10.718 22.997-4.226 1.00 47.77 A C原子1394 C VAL A 208 11.782 25.767-4.261 1.00 49.99 A C原子1395 O VAL A 208 11.149 26.553-4.968 1.00 50.65 A O原子1396 N ARG A 209 13.035 25.385-4.510 1.00 53.00 A N原子1397 CA ARG A 209 13.792 25.840-5.676 1.00 56.27 A C原子1398 CB ARG A 209 15.256 25.338-5.611 1.00 59.41 A C原子1399 CG ARG A 209 15.535 23.905-6.108 1.00 63.33 A C原子1400 CD ARG A 209 15.206 22.796-5.109 1.00 67.47 A C原子1401 NE ARG A 209 15.000 21.486-5.751 1.00 70.85 A N原子1402 CZ ARG A 209 15.943 20.743-6.340 1.00 71.66 A C原子1403 NH1 ARG A 209 17.210 21.151-6.399 1.00 71.51 A N原子1404 NH2 ARG A 209 15.613 19.571-6.874 1.00 70.99 A N原子1405 C ARG A 209 13.130 25.503-7.019 1.00 55.85 A C原子1406 O ARG A 209 12.474 24.461-7.153 1.00 56.16 A O原子1407 N GLY A 210 13.232 26.443-7.959 1.00 55.61 A N原子1408 CA GLY A 210 12.657 26.272-9.283 1.00 54.50 A C原子1409 C GLY A 210 11.200 26.676-9.437 1.00 53.43 A C原子1410 O GLY A 210 10.759 26.932-10.562 1.00 53.60 A O原子1411 N GLU A 211 10.458 26.727-8.326 1.00 52.91 A N原子1412 CA GLU A 211 9.033 27.098-8.324 1.00 53.50 A C
原子1413 CB GLU A 211 8.260 26.209-7.338 1.00 56 66 A C原子1414 CG GLU A 211 8.097 24.768-7.833 1.00 63.39 A C原子1415 CD GLU A 211 7.567 23.802-6.778 1.00 66.35 A C原子1416 OE1 GLU A 211 8.287 22.830-6.455 1.00 68.23 A O原子1417 OE2 GLU A 211 6.439 24.000-6.273 1.00 68.02 A O原子1418 C GLU A 211 8.839 28.585-7.994 1.00 50.77 A C原子1419 O GLU A 211 9.065 28.990-6.857 1.00 53.00 A O原子1420 N PRO A 212 8.401 29.412-8.978 1.00 48.23 A N原子1421 CD PRO A 212 8.073 29.052-10.372 1.00 47.12 A C原子1422 CA PRO A 212 8.192 30.855-8.774 1.00 45.39 A C原子1423 CB PRO A 212 7.833 31.355-10.177 1.00 43.61 A C原子1424 CG PRO A 212 7.180 30.189-10.798 1.00 45.59 A C原子1425 C PRO A 212 7.180 31.312-7.718 1.00 43.14 A C原子1426 O PRO A 212 6.031 30.856-7.676 1.00 43.13 A O原子1427 N ASN A 213 7.650 32.215-6.860 1.00 39.61 A N原子1428 CA ASN A 213 6.855 32.788-5.775 1.00 36.37 A C原子1429 CB ASN A 213 7.588 32.624-4.439 1.00 35.62 A C原子1430 CG ASN A 213 8.398 31.328-4.356 1.00 35.34 A C原子1431 OD1 ASN A 213.7.841 30.233-4.220 1.00 32.84 A O原子1432 ND2 ASN A 213 9.724 31.454-4.454 1.00 33.41 A N原子1433 C ASN A 213 6.679 34.273-6.097 1.00 34.54 A C原子1434 O ASN A 213 7.559 34.860-6.739 1.00 30.67 A O原子1435 N VAL A 214 5.563 34.862-5.637 1.00 32.85 A N原子1436 CA VAL A 214 5.198 36.282-5.867 1.00 33.27 A C原子1437 CB VAL A 214 3.783 36.633-5.275 1.00 34.50 A C原子1438 CG1 VAL A 214 2.682 36.064-6.143 1.00 34.62 A C原子1439 CG2 VAL A 214 3.633 36.109-3.833 1.00 31.85 A C原子1440 C VAL A 214 6.176 37.360-5.372 1.00 34.39 A C
原子1441 O VAL A 214 6.724 37.258-4.267 1.00 34.49 A O原子1442 N SER A 215 6.356 38.405-6.186 1.00 33.74 A N原子1443 CA SER A 215 7.249 39.531-5.867 1.00 32.25 A C原子1444 CB SER A 215 7.706 40.237-7.133 1.00 30.98 A C原子1445 OG SER A 215 8.626 39.422-7.815 1.00 34.87 A O原子1446 C SER A 215 6.638 40.562-4.934 1.00 30.58 A C原子1447 O SER A 215 7.310 41.050-4.030 1.00 31.79 A O原子1448 N PTR A 216 5.381 40.917-5.178 1.00 28.49 A N原子1449 CA PTR A 216 4.690 41.890-4.347 1.00 27.79 A C原子1450 CB PTR A 216 3.558 42.573-5.132 1.00 27.56 A C原子1451 CG PTR A 216 3.198 43.941-4.605 1.00 26.28 A C原子1452 CD1 PTR A 216 4.146 44.992-4.616 1.00 26.29 A C原子1453 CE1 PTR A 216 3.833 46.272-4.102 1.00 25.08 A C原子1454 CD2 PTR A 216 1.919 44.198-4.069 1.00 27.05 A C原子1455 CE2 PTR A 216 1.587 45.486-3.542 1.00 26.39 A C原子1456 CZ PTR A 216 2.553 46.507-3.567 1.00 27.76 A C原子1457 OH PTR A 216 2.246 47.746-3.064 1.00 29.85 A O原子1458 C PTR A 216 4.183 41.173-3.091 1.00 28.51 A C原子1459 O PTR A 216 3.073 40.617-3.049 1.00 28.32 A O原子1460 P PTR A 216 2.743 48.116-1.618 1.00 30.02 A P原子1461 OIT PTR A 216 1.765 49.242-1.160 1.00 29.39 A O原子1462 02P PTR A 216 4.171 48.722-1.822 1.00 28.79 A O原子1463 03P PTR A 216 2.743 46.943-0.686 1.00 28.98 A O原子1464 N ILE AS 217 5.066 41.154-2.092 1.00 29.04 A N原子1465 CA ILE A 217 4.836 40.512-0.805 1.00 27.27 A C原子1466 CB ILE A 217 5.189 38.975-0.929 1.00 27.34 A C原子1467 CG2 ILE A 217 6.703 38.740-1.007 1.00 24.93 A C原子1468 CG1 ILE A 217 4.467 38.150 0.140 1.00 29.00 A C
原子1469 CD I ILE A 217 2.943 38.019-0.058 1.00 27.14 A C原子1470 C ILE A 217 5.666 41.288 0.256 1.00 27.97 A C原子1471 O ILE AS 217 6.634 41.965-0.099 1.00 24.98 A O原子1472 N CYS A 218 5.272 41.177 1.537 1.00 29.57 A N原子1473 CA CYS A 218 5.862 41.861 2.722 1.00 28.63 A C原子1474 CB CYS A 218 7.398 41.890 2.751 1.00 30.93 A C原子1475 SG CYS A 218 8.206 40.392 2.332 1.00 38.61 A S原子1476 C CYS A 218 5.420 43.303 2.845 1.00 27.95 A C原子1477 O CYS A 218 5.154 43.972 1.834 1.00 29.09 A O原子1478 N SER A 219 5.392 43.802 4.084 1.00 26.02 A N原子1479 CA SER A 219 5.035 45.195 4.331 1.00 23.32 A C原子1480 CB SER A 219 4.883 45.460 5.811 1.00 22.90 A C原子1481 OG SER A 219 3.863 44.645 6.338 1.00 25.98 A O原子1482 C SER A 219 6.174 46.014 3.749 1.00 22.69 A C原子1483 O SER A 219 7.353 45.691 3.937 1.00 21.63 A O原子1484 N ARG A 220 5.780 46.967 2.913 1.00 22.94 A N原子1485 CA ARG A 220 6.665 47.858 2.180 1.00 22.75 A C原子1486 CB ARG A 220 5.899 49.112 1.745 1.00 24.79 A C原子1487 CG ARG A 220 6.578 49.889 0.605 1.00 28.86 A C原子1488 CD ARG A 220 5.952 51.233 0.388 1.00 29.90 A C原子1489 NE ARG A 220 4.591 51.110-0.123 1.00 34.40 A N原子1490 CZ ARG A 220 3.579 51.908 0.211 1.00 35.77 A C原子1491 NH1 ASRG A 220 3.755 52.911 1.069 1.00 33.84 A N原子1492 NH2 ARG A 220 2.383 51.706-0.330 1.00 38.27 A N原子1493 C ARG A 220 7.986 48.255 2.823 1.00 21.80 A C原子1494 O ARG A 220 9.035 47.959 2.272 1.00 19.45 A O原子1495 N TYR A 221 7.924 48.799 4.039 1.00 22.04 A N原子1496 CA TYR A 221 9.113 49.277 4.747 1.00 21.20 A C
原子1497 CB TYR A 221 8.706 49.992 6.047 1.00 20.06 A C原子1498 CG TYR A 221 7.763 51.192 5.922 1.00 23.24 A C原子1499 CD1 TYR A 221 7.231 51.804 7.082 1.00 23.96 A C原子1500 CE1 TYR A 221 6.349 52.922 6.995 1.00 22.05 A C原子1501 CD2 TYR A 221 7.386 51.727 4.665 1.00 22.76 A C原子1502 CE2 TYR A 221 6.504 52.835 4.571 1.00 22.62 A C原子1503 CZ TYR A 221 6.001 53.425 5.739 1.00 23.22 A C原子1504 OH TYR A 221 5.192 54.528 5.646 1.00 26.64 A O原子1505 C TYR A 221 10.156 48.203 5.055 1.00 21.73 A C原子1506 O TYR A 221 11.336 48.502 5.278 1.00 21.18 A O原子1507 N TYR A 222 9.715 46.950 4.978 1.00 22.51 A N原子1508 CA TYR AS 222 10.540 45.782 5.304 1.00 22.04 A C原子1509 CB TYR A 222 9.821 44.952 6.389 1.00 20.59 A C原子1510 CG TYR A 222 9.331 45.808 7.543 1.00 21.83 A C原子1511 CD1 TYR A 222 10.195 46.148 8.606 1.00 22.50 A C原子1512 CE1 TYR A 222 9.802 47.078 9.609 1.00 21.27 A C原子1513 CD2 TYR A 222 8.047 46.401 7.513 1.00 17.37 A C原子1514 CE2 TYR A 222 7.639 47.327 8.510 1.00 16.78 A C原子1515 CZ TYR A 222 8.527 47.662 9.548 1.00 20.10 A C原子1516 OH TYR A 222 8.167 48.582 10.502 1.00 21.58 A O原子1517 C TYR A 222 10.877 44.911 4.106 1.00 20.47 A C原子1518 O TYR A 222 11.677 43.987 4.220 1.00 22.09 A O原子1519 N ARG A 223 10.305 45.247 2.953 1.00 19.61 A N原子1520 CA ARG A 223 10.501 44.506 1.710 1.00 19.52 A C原子1521 CB ARG A 223 9.487 45.008 0.689 1.00 20.62 A C原子1522 CG ARG A 223 9.364 44.214-0.591 1.00 22.09 A C原子1523 CD ARG A 223 8.304 44.815-1.504 1.00 19.75 A C原子1524 NE ARG A 223 6.965 44.700-0.933 1.00 17.36 A N
原子1525 CZ ARG A 223 6.023 45.636-0.989 1.00 18.98 A C原子1526 NH1 ARG A 223 6.251 46.800-1.598 1.00 18.60 A N原子1527 NH2 ARG A 223 4.843 45.404-0.421.1.00 19.71 A N原子1528 C ARG A 223 11.930 44.568 1.154 1.00 22.14 A C原子1529 O ARG A 223 12.491 45.648 0.935 1.00 21.59 A O原子1530 N ALA A 224 12.507 43.385 0.947 1.00 25.00 A N原子1531 CA ALA A 224 13.865 43.228 0.422 1.00 28.52 A C原子1532 CB ALA A 224 14.297 41.765 0.524 1.00 28.25 A C原子1533 C ALA A 224 14.011 43.749-1.006 1.00 29.59 A C原子1534 O ALA A 224 13.070 43.645-1.792 1.00 30.88 A O原子1535 N PRO A 225 15.190 44.315-1.360 1.00 30.76 A N原子1536 CD PRO A 225 16.382 44.545-0.526 1.00 29.59 A C原子1537 CA PRO A 225 15.420 44.849-2.705 1.00 31.34 A C原子1538 CB PRO A 225 16.798 45.499-2.592 1.00 31.48 A C原子1539 CG PRO A 225 17.471 44.689-1.529 1.00 32.57 A C原子1540 C PRO A 225 15.273 43.895-3.891 1.00 31.12 A C原子1541 O PRO A 225 15.088 44.353-5.001 1.00 32.29 A O原子1542 N GLU A 226 15.254 42.585-3.640 1.00 32.81 A N原子1543 CA GLU A 226 15.065 41.582-4.706 1.00 33.56 A C原子1544 CB GLU A 226 15.218 40.144-4.194 1.00 34.04 A C原子1545 CG GLU A 226 16.510 39.804-3.531 1.00 34.67 A C原子1546 CD GLU A 226 16.536 40.202-2.078 1.00 36.49 A C原子1547 OE1 GLU A 226 16.222 39.353-1.218 1.00 37.14 A O原子1548 OE2 GLU A 226 16.882 41.368-1.796 1.00 34.66 A O原子1549 C GLU A 226 13.643 41.709-5.219 1.00 34.54 A C原子1550 O GLU A 226 13.410 41.667-6.428 1.00 35.78 A O原子1551 N LEU A 227 12.709 41.906-4.283 1.00 34.91 A N原子1552 CA LEU A 227 11.291 42.042-4.601 1.00 36.36 A C
原子1553 CB LEU A 227 10.423 41.853-3.359 1.00 40.67 A C原子1554 CG LEU A 227 10.400 40.586-2.500 1.00 43.41 A C原子1555 CD1 LEU A 227 10.793 39.370-3.290 1.00 43.06 A C原子1556 CD2 LEU A 227 11.305 40.766-1.331 1.00 43.69 A C原子1557 C LEU A 227 10.929 43.358-5.267 1.00 34.40 A C原子1558 O LEU A 227 9.933 43.423-6.001 1.00 35.29 A O原子1559 N ILE A 228 11.713 44.405-4.989 1.00 32.56 A N原子1560 CA ILE A 228 11.487 45.720-5.608 1.00 32.16 A C原子1561 CB ILE A 228 12.358 46.862-4.988 1.00 32.60 A C原子1562 CG2 ILE A 228 11.880 48.216-5.523 1.00 28.97 A C原子1563 CG1 ILE A 228 12.362 46.827-3.443 1.00 31.25 A C原子1564 CD1 ILE A 228 11.095 47.221-2.742 1.00 35.65 A C原子1565 C ILE A 228 11.876 45.552-7.090 1.00 30.83 A C原子1566 O ILE A 228 11.167 46.024-7.986 1.00 28.70 A O原子1567 N PHE A 229 12.960 44.802-7.314 1.00 29.19 A N原子1568 CA PHE A 229 13.464 44.485-8.651 1.00 30.76 A C原子1569 CB PHE A 229 14.955 44.130-8.607 1.00 27.42 A C原子1570 CG PHE A 229 15.870 45.324-8.493 1.00 26.49 A C原子1571 CD1 PHE A 229 16.420 45.695-7.254 1.00 25.53 A C原子1572 CD2 PHE A 229 16.201 46.078-9.627 1.00 26.43 A C原子1573 CE1 PHE A 229 17.297 46.811-7.133 1.00 26.62 A C原子1574 CE2 PHE A 229 17.079 47.204-9.540 1.00 29.28 A C原子1575 CZ PHE A 229 17.630 47.572-8.280 1.00 29.17 A C原子1576 C PHE A 229 12.650 43.343-9.287 1.00 32.87 A C原子1577 O PHE A 229 12.965 42.873-10.388 1.00 33.65 A O原子1578 N GLY A 230 11.623 42.890-8.564 1.00 33.72 A N原子1579 CA GLY A 230 10.731 41.851-9.054 1.00 35.89 A C原子1580 C GLY A 230 11.176 40.400-9.164 1.00 37.51 A C
原子1581 O GLY A 230 10.628 39.667-10.002 1.00 36.98 A O原子1582 N ALA A 231 12.084 39.957-8.288 1.00 37.64 A N原子1583 CA ALA A 231 12.574 38.575-8.302 1.00 38.38.32 A C原子1584 CB ALA A 231 13.759 38.424-7.391 1.00 37.75 A C原子1585 C ALA A 231 11.485 37.590-7.898 1.00 40.02 A C原子1586 O ALA A 231 10.649 37.893-7.040 1.00 40.82 A O原子1587 N THR A 232 11.463 36.443-8.574 1.00 39.60 A N原子1588 CA THR A 232 10.483 35.401-8.299 1.00 39.65 A C原子1589 CB THR A 232 9.559 35.132-9.533 1.00 41.94 A C原子1590 OG1 THR A 232 10.346 35.024-10.730 1.00 42.76 A O原子1591 CG2 THR A 232 8.512 36.249-9.696 1.00 40.72 A C原子1592 C THR A 232 11.133 34.105-7.803 1.00 39.31 A C原子1593 O THR A 232 10.434 33.172-7.400 1.00 40.10 A O原子1594 N ASP A 233 12.468 34.077-7.795 1.00 40.13 A N原子1595 CA ASP A 233 13.250 32.916-7.348 1.00 41.25 A C原子1596 CB ASP A 233 14.129 32.374-8.506 1.00 43.94 A C原子1597 CG ASP A 233 15.313 33.306-8.884 1.00 47.47.37 A C原子1598 OD1 ASP A 233 16.351 32.771-9.350 1.00 46.27 A O原子1599 OD2 ASP A 233 15.219 34.546-8.700 1.00 48.50 A O原子1600 C ASP A 233 14.101 33.250-6.110 1.00 41.12 A C原子1601 O ASP A 233 15.211 32.729-5.940 1.00 41.52 A O原子1602 N TYR A 234 13.569 34.126-5.257 1.00 39.65 A N原子1603 CA TYR A 234 14.250 34.579-4.038 1.00 39.13 A C原子1604 CB TYR A 234 13.617 35.892-3.531 1.00 36.13 A C原子1605 CG TYR A 234 12.118 35.822-3.293 1.00 34.48 A C原子1606 CD1 TYR A 234 11.595 35.516-2.014 1.00 33.16 A C原子1607 CE1 TYR A 234 10.204 35.407-1.798 1.00 33.47 A C原子1608 CD2 TYR A 234 11.213 36.025-4.351 1.00 34.12 A C
原子1609 CE2 TYR A 234 9.810 35.923-4.149 1.00 36.01 A C原子1610 CZ TYR A 234 9.319 35.611-2.868 1.00 35.41 A C原子1611 OH TYR A 234 7.961 35.483-2.668 1.00 35.00 A O原子1612 C TYR A 234 14.284 33.536-2.911 1.00 40.34 A C原子1613 O TYR A 234 13.336 32.748-2.753 1.00 40.52 A O原子1614 N THR A 235 15.355 33.582-2.113 1.00 40.13 A N原子1615 CA THR A 235 15.551 32.672-0.978 1.00 39.29 A C原子1616 CB THR A 235 17.064 32.367-0.746 1.00 40.43 A C原子1617 OG1 THR A 235 17.808 33.592-0.636 1.00 45.53 A O原子1618 CG2 THR A 235 17.626 31.550-1.899 1.00 39.97 A C原子1619 C THR A 235 14.903 33.229 0.295 1.00 36.84 A C原子1620 O THR A 235 14.415 34.360 0.297 1.00 36.88 A O原子1621 N SER A 236 14.906 32.441 1.376 1.00 35.70 A N原子1622 CA SER A 236 14.308 32.842 2.664 1.00 33.11 A C原子1623 CB SER A 236 14.196 31.645 3.614 1.00 32.13 A C原子1624 OG SER A 236 15.465 31.228 4.076 1.00 36.13 A O原子1625 C SER A 236 15.044 34.005 3.327 1.00 30.51 A C原子1626 O SER A 236 14.610 34.549 4.345 1.00 29.27 A O原子1627 N SER A 237 16.109 34.426 2.648 1.00 27.13 A N原子1628 CA SER A 237 16.983 35.535 2.997 1.00 22.41 A C原子1629 CB SER A 237 18.086 35.598 1.939 1.00 20.91 A C原子1630 OG SER A 237 18.953 36.686 2.118 1.00 24.91 A O原子1631 C SER A 237 16.226 36.876 3.067 1.00 21.98 A C原子1632 O SER A 237 16.749 37.852 3.610 1.00 23.14 A O原子1633 N IL A 238 15.003 36.923 2.521 1.00 20.97 A N原子1634 CA ILE A 238 14.172 38.137 2.547 1.00 19.72 A C原子1635 CB ILE A 238 12.949 38.060 1.604 1.00 18.06 A C原子1636 CG2 ILE A 238 13.404 38.049 0.153 1.00 19.86 A C
原子1637 CG1 ILE A 238 12.091 36.833 1.902 1.00 18.85 A C原子1638 CD1 ILE A 238 10.645 37.047 1.563 1.00 15.98 A C原子1639 C ILE A 238 13.710 38.482 3.965 1.00 20.89 A C原子1640 O IL A 238 13.580 39.663 4.309 1.00 20.87 A O原子1641 N ASP A 239 13.520 37.438 4.783 1.00 22.24 A N原子1642 CA ASP A 239 13.119 37.559 6.189 1.00 21.94 A C原子1643 CB ASP A 239 12.774 36.188 6.807 1.00 23.31 A C原子1644 CG ASP A 239 11.451 35.604 6.305 1.00 25.59 A C原子1645 OD1 ASP A 239 10.643 36.323 5.675 1.00 24.86 A O原子1646 OD2 ASP A 239 11.216 34.398 6.556 1.00 26.08 A O原子1647 C ASP A 239 14.286 38.153 6.962 1.00 20.53 A C原子1648 O ASP A 239 14.079 38.904 7.918 1.00 22.47 A O原子1649 N VAL A 240 15.505 37.855 6.505 1.00 17.51 A N原子1650 CA VAL A 240 16.721 38.366 7.138 1.00 17.98 A C原子1651 CB VAL A 240 17.994 37.592 6.679 1.00 16.44 A C原子1652 CG1 VAL A 240 19.247 38.139 7.350 1.00 13.47 A C原子1653 CG2 VAL A 240 17.849 36.105 7.022 1.00 13.28 A C原子1654 C VAL A 240 16.864 39.867 6.913 1.00 17.18 A C原子1655 O VAL A 240 17.247 40.588 7.825 1.00 20.03 A O原子1656 N TRP A 241 16.520 40.332 5.713 1.00 19.12 A N原子1657 CA TRP A 241 16.568 41.761 5.384 1.00 17.41 A C原子1658 CB TRP A 241 16.226 41.995 3.904 1.00 17.34 A C原子1659 CG TRP A 241 15.955 43.466 3.563 1.00 18.47 A C原子1660 CD2 TRP A 241 16.898 44.415 3.078 1.00 19.08 A C原子1661 CE2 TRP A 241 16.217 45.664 2.964 1.00 18.40 A C原子1662 CE3 TRP A 241 18.259 44.343 2.714 1.00 18.24 A C原子1663 CD1 TRP A 2412 14.764 44.157 3.712 1.00 18.48 A C原子1664 NE1 TRP A 241 14.921 45.469 3.360 1.00 19.49 A N
原子1665 CZ2 TRP A 241 16.852 46.824 2.507 1.00 16.68 A C原子1666 CZ3 TRP A 241 18.892 45.515 2.250 1.00 8.40 A C原子1667 CH2 TRP A 241 18.182 46.733 2.155 1.00 16.97 A C原子1668 C TRP A 241 15.532 42.477 6.259 1.00 15.48 A C原子1669 O TRP A 241 15.805 43.542 6.822 1.00 14.74 A O原子1670 N SER A 242 14.318 41.932 6.237 1.00 12.59 A N原子1671 CA SER A 242 13.195 42.443 7.005 1.00 13.83 A C原子1672 CB SER A 242 11.996 41.532 6.844 1.00 11.05 A C原子1673 OG SER A 242 11.493 41.552 5.526 1.00 16.25 A O原子1674 C SER A 242 13.542 42.560 8.474 1.00 15.02 A C原子1675 SER A 242 13.247 43.578 9.092 1.00 16.74 A O原子1676 N ALA A 243 14.266 41.552 8.978 1.00 16.60 A N原子1677 CA ALA A 243 14.721 41.479 10.368 1.00 14.09 A C原子1678 CB ALA A 243 15.329 40.1244 10.6412 12.00 11.12 A C原子1679 C ALA A 243 15.714 42.590 10.650 1.00 15.69 A C原子1680 O ALA A 243 15.698 43.189 11.728 1.00 16.31 A O原子1681 N GLY A 244 16.527 42.901 9.641 1.00 16.63 A N原子1682 CA GLY A 244 17.504 43.975 9.741 1.00 19.58 A C原子1683 C GLY A 244 16.845 45.346 9.777 1.00 20.75 A C原子1684 O GLY A 244 17.396 46.275 10.367 1.00 22.25 A O原子1685 N CYS A 245 15.676 45.464 9.132 1.00 20.19 A N原子1686 CA CYS A 245 14.895 46.697 9.097 1.00 18.63 A C原子1687 CB CYS A 245 13.796 46.620 8.037 1.00 19.55 A C原子1688 SG CYS A 245 14.354 46.652 6.290 1.00 22.46 A S原子1689 C CYS A 245 14.291 46.923 10.481 1.00 17.40 A C原子1690 O CYS A 245 14.195 48.057 10.939 1.00 19.09 A O原子1691 N VAL A 246 13.965 45.825 11.168 1.00 16.69 A N原子1692 CA VAL A 246 13.413 45.861 12.534 1.00 17.03 A C
原子1693 CB VAL A 246 12.923 44.462 13.011 1.00 17.12 A C原子1694 CG1 VAL A 246 12.365 44.543 14.444 1.00 14.75 A C原子1695 CG2 VAL A 246 11.907 43.882 12.038 1.00 13.18 A C原子1696 C VAL A 246 14.521 46.320 13.494 1.00 16.65 A C原子1697 O VAL A 246 14.304 47.203 14.320 1.00 19.70 A O原子1698 N LEU A 247 15.704 45.728 13.352 1.00 15.00 A N原子1699 CA LEU A 247 16.861 46.068 14.170 1.00 17.14 A C原子1700 CB LEU A 247 18.072 45.219 13.764 1.00 18.29 A C原子1701 CG LEU A 247 19.389 45.551 14.467 1.00 18.64 A C原子1702 CD1 LEU A 247 19.332 45.227 15.953 1.00 19.89 A C原子1703 CD2 LEU A 247 20.497 44.819 13.806 1.00 20.99 A C原子1704 C LEU A 247 17.198 47.548 14.059 1.00 16.69 A C原子1705 O LEU A 247 17.345 48.245 15.070 1.00 17.59 A O原子1706 N ALA A 248 17.206 48.030 12.824 1.00 16.14 A N原子1707 CA ALA A 248 17.501 49.414 12.546 1.00 15.97 A C原子1708 CB ALA A 248 17.626 49.605 11.071 1.00 17.23 A C原子1709 C ALA A 248 16.446 50.340 13.143 1.00 16.83 A C原子1710 O ALA A 248 16.795 51.332 13.780 1.00 19.30 A O原子1711 N GLU A 249 15.175 49.927 13.061 1.00 18.04 A N原子1712 CA GLU A 249 14.036 50.695 13.591 1.00 18.02 A C原子1713 CB GLU A 249 12.714 50.021 13.181 1.00 17.49 A C原子1714 CG GLU A 249 11.427 50.757 13.588 1.00 18.63 A C原子1715 CD GLU A 249 10.192 50.296 12.816 1.00 24.35 A C原子1716 OE1 GLU A 249 10.320 49.876 11.643 1.00 23.91 A O原子1717 OE2 GLU A 249 9.074 50.384 13.372 1.00 28.62 A O原子1718 C GLU A 249 14.119 50.818 15.120 1.00 19.52 A C原子1719 O GLU A 249 13.918 51.906 15.690 1.00 15.73 A O原子1720 N LEU A 250 14.515 49.716 15.756 1.00 19.28 A N
原子1721 CA LEU A 250 14.625 49.656 17.208 1.00 20.52 A C原子1722 CB LEU A 250 14.779 48.199 17.682 1.00 21.30 A C原子1723 CG LEU A 250 13.574 47.239 17.537 1.00 18.87 A C原子1724 CD1 LEU A 250 13.786 46.050 18.423 1.00 16.34 A C原子1725 CD2 LEU A 250 12.262 47.916 17.942 1.00 17.21 A C原子1726 C LEU A 250 15.716 50.545 17.778 1.00 20.14 A C原子1727 O LEU A 250 15.600 51.023 18.912 1.00 22.30 A O原子1728 N LEU A 251 16.713 50.843 16.946 1.00 18.89 A N原子1729 CA LEU A 251 17.840 51.697 17.336 1.00 18.41 A C原子1730 CB LEU A 251 19.127 51.214 16.660 1.00 12.63 A C原子1731 CG LEU A 251 19.555 49.767 16.953 1.00 10.51 A C原子1732 CD1 LEU A 251 20.565 49.278 15.919 1.00 5.57 A C原子1733 CD2 LEU A 251 20.090 49.633 18.370 1.00 9.38 A C原子1734 C LEU A 251 17.597 53.155 16.971 1.00 19.33 A C原子1735 O LEU A 251 18.084 54.066 17.651 1.00 21.92 A O原子1736 N LEU A 252 16.844 53.367 15.896 1.00 17.42 A N原子1737 CA LEU A 252 16.557 54.702 15.409 1.00 18.59 A C原子1738 CB LEU A 252 16.387 54.677 13.899 1.00 21.67 A C原子1739 CG LEU A 252 17.688 54.802 13.124 1.00 22.29 A C原子1740 CD1 LEU A 252 17.494 54.355 11.697 1.00 27.61 A C原子1741 CD2 LEU A 252 18.164 56.241 13.184 1.00 27.99 A C原子1742 C LEU A 252 15.364 55.373 16.030 1.00 20.79 A C原子1743 O LEU A 252 15.317 56.611 16.109 1.00 21.21 A O原子1744 N GLY A 253 14.387 54.553 16.420 1.00 22.24 A N原子1745 CA GLY A 253 13.160 55.051 17.022 1.00 24.26 A C原子1746 C GLY A 253 12.086 55.367 15.993 1.00 26.26 A C原子1747 O GLY A 253 11.047 55.940 16.319 1.00 27.52 A O原子1748 N GLN A 254 12.382 55.056 14.735 1.00 26.36 A N
原子1749 CA GLN A 254 11.477 55.270 13.605 1.00 28.51 A C原子1750 CB GLN A 254 11.479 56.755 13.172 1.00 30.13 A C原子1751 CG GLN A 254 12.843 57.346 12.871 1.00 33.35 A C原子1752 CD GLN A 254 12.760 58.511 11.930 1.00 36.40 A C原子1753 OE1 GLN A 254 13.138 58.409 10.759 1.00 38.80 A O原子1754 NE2 GLN A 254 12.251 59.629 12.423 1.00 39.90 A N原子1755 C GLN A 254 11.955 54.350 12.463 1.00 27.98 A C原子1756 O GLN A 254 13.128 53.954 12.446 1.00 31.61 A O原子1757 N PRO A 255 11.057 53.945 11.532 1.00 25.97 A N原子1758 CD PRO A 255 9.587 54.063 11.504 1.00 26.58 A C原子1759 CA PRO A 255 11.507 53.067 10.438 1.00 24.03 A C原子1760 CB PRO A 255 10.212 52.774 9.669 1.00 23.65 A C原子1761 CG PRO A 255 9.300 53.870 10.052 1.00 25.92 A C原子1762 C PRO A 255 12.620 53.635 9.571 1.00 21.35 A C原子1763 O PRO A 255 12.608 54.825 9.242 1.00 21.96 A O原子1764 N ILE A 256 13.614 52.790 9.287 1.00 19.07 A N原子1765 CA ILE A 256 14.773 53.188 8.496 1.00 17.54 A C原子1766 CB IL A 256 15.973 52.179 8.629 1.00 17.39 A C原子1767 CG2 ILE A 256 15.591 50.769 8.162 1.00 13.59 A C原子1768 CG1 ILE A 256 17.237 52.746 7.939 1.00 16.44 A C原子1769 CD1 ILE A 256 18.494 51.913 8.077 1.00 14.86 A C原子1770 C ILE A 256 14.435 53.466 7.049 1.00 20.68 A C原子1771 O ILE A 256 14.965 54.408 6.448 1.00 21.57 A O原子1772 N PHE A 257 13.533 52.666 6.484 1.00 22.77 A N原子1773 CA PHE A 257 13.143 52.861 5.087 1.00 22.10 A C原子1774 CB PHE A 257 13.566 51.668 4.223 1.00 19.66 A C原子1775 CG PHE A 257 15.002 51.308 4.341 1.00 16.70 A C原子1776 CD1 PHE A 257 16.007 52.286 4.181 1.00 16.19 A C
原子1777 CD2 PHE A 257 15.370 49.980 4.597 1.00 16.77 A C原子1778 CE1 PHE A 257 17.353 51.948 4.272 1.00 13.12 A C原子1779 CE2 PHE A 257 16.728 49.615 4.693 1.00 16.25 A C原子1780 CZ PHE A 257 17.723 50.599 4.529 1.00 16.81 A C原子1781 C PHE A 257 11.652 53.146 4.882 1.00 22.20 A C原子1782 O PHE A 257 10.916 52.269 4.434 1.00 24.07 A O原子1783 N PRO A 258 11.202 54.392 5.143 1.00 23.42 A N原子1784 CD PRO A 258 11.883 55.506 5.845 1.00 22.97 A C原子1785 CA PRO A 258 9.776 54.695 4.964 1.00 25.60 A C原子1786 CB PRO A 258 9.542 55.782 6.009 1.00 25.06 A C原子1787 CG PRO A 258 10.825 56.580 5.924 1.00 23.84 A C原子1788 C PRO A 258 9.320 55.130 3.561 1.00 27.86 A C原子1789 O PRO A 258 8.834 56.252 3.378 1.00 31.43 A O原子1790 N GLY A 259 9.388 54.216 2.597 1.00 28.74 A N原子1791 CA GLY A 259 8.993 54.542 1.232 1.00 31.74 A C原子1792 C GLY A 259 7.507 54.768 0.989 1.00 33.82 A C原子1793 O GLY A 259 6.659 54.242 1.726 1.00 33.71 A O原子1794 N ASP A 260 7.195 55.572-0.030 1.00 34.60 A N原子1795 CA ASP A 260 5.803 55.871-0.393 1.00 35.75 A C原子1796 CB ASP A 260 5.675 57.284-0.949 1.00 37.17 A C原子1797 CGT ASP A 260 5.595 58.325 0.143 1.00 42.70 A C原子1798 OD1 ASP A 260 6.291 59.362 0.022 1.00 43.50 A O原子1799 OD2 ASP A 260 4.831 58.104 1.122 1.00 42.33 A O原子1800 C ASP A 260 5.212 54.878-1.378 1.00 34.19 A C原子1801 O ASP A 260 4.006 54.649-1.386 1.00 35.08 A O原子1802 N SER A 261 6.082 54.269-2.175 1.00 32.74 A N原子1803 CA SER A 261 5.687 53.292-3.183 1.00 32.28 A C原子1804 CB SER A 261 5.565 53.973-4.560 1.00 33.32 A C
原子1805 OG SER A 261 6.808 54.524-4.983 1.00 32.63 A O原子1806 C SER A 261 6.757 52.217-3.246 1.00 30.14 A C原子1807 O SER A 261 7.752 52.282-2.521 1.00 30.74 A O原子1808 N GLY A 262 6.550 51.248-4.134 1.00 28.27 A N原子1809 CA GLY A 262 7.510 50.181-4.345 1.00 28.00 A C原子1810 C GLY A 262 8.793 50.742-4.929 1.00 28.04 A C原子1811 O GLY A 262 9.879 50.317-4.550 1.00 29.79 A O原子1812 N VAL A 263 8.666 51.776-5.759 1.00 29.12 A N原子1813 CA VAL A 263 9.824 52.413-6.382 1.00 30.23 A C原子1814 CB VAL A 263 9.472 53.147-7.729 1.00 31.30 A C原子1815 CG1 VAL A 263 10.749 53.439-8.515 1.00 30.29 A C原子1816 CG2 VAL A 263 8.539 52.292-8.597 1.00 31.94 A C原子1817 C VAL A 263 10.497 53.371-5.398 1.00 29.25 A C原子1818 O VAL A 263 11.724 53.418-5.328 1.00 29.30 A O原子1819 N ASP A 264 9.700 54.082-4.599 1.00 29.24 A N原子1820 CA ASP A 264 10.256 55.010-3.607 1.00 28.75 A C原子1821 CB ASP A 264 9.199 55.978-3.047 1.00 30.46 A C原子1822 CG ASP A 264 9.812 57.046-2.144 1.00 33.03 A C原子1823 OD1 ASP A 264 10.871 57.603-2.512 1.00 34.94 A O原子1824 OD2 ASP A 264 9.280 57.278-1.040 1.00 37.33 A O原子1825 C ASP A 264 10.971 54.270-2.469 1.00 26.56 A C原子1826 O ASP A 264 11.865 54.831-1.829 1.00 26.01 A O原子1827 N GLN A 265 10.572 53.018-2.234 1.00 23.87 A N原子1828 CA GLN A 265 11.198 52.175-1.219 1.00 23.64 A C原子1829 CB GLN A 265 10.468 50.836-1.079 1.00 22.07 A C原子1830 CG GLN A 265 10.926 49.971 0.110 1.00 19.47 A C原子1831 CD GLN A 265 10.674 50.606 1.468 1.00 21.09 A C原子1832 OE1 GLN A 265 11.471 50.457 2.389 1.00 23.45 A O
原子1833 NE2 GLN A 265 9.535 51.265 1.618 1.00 22.26 A N原子1834 C GLN A 265 12.659 51.931-1.609 1.00 24.35 A C原子1835 O GLN A 265 13.541 51.905-0.740 1.00 19.95 A O原子1836 N LEU A 266 12.903 51.815-2.920 1.00 24.99 A N原子1837 CA LEU A 266 14.252 51.604-3.440 1.00 26.98 A C原子1838 CB LEU A 266 14.209 51.120-4.887 1.00 30.33 A C原子1839 CG LEU A 266 15.506 50.603-5.530 1.00 33.62 A C原子1840 CD1 LEU A 266 16.128 49.484-4.695 1.00 34.02 A C原子1841 CD2 LEU A 266 15.218 50.126-6.937 1.00 33.72 A C原子1842 C LEU A 266 15.102 52.879-3.320 1.00 25.91 A C原子1843 O LEU A 266 16.282 52.799-3.029 1.00 25.13 A O原子1844 N VAL A 267 14.471 54.044-3.450 1.00 25.29 A N原子1845 CA VAL A 267 15.169 55.330-3.342 1.00 26.05 A C原子1846 CB VAL A 267 14.271 56.515-3.778 1.00 25.47 A C原子1847 CG1 VAL A 267 15.064 57.829-3.762 1.00 23.88 A C原子1848 CG2 VAL A 267 13.712 56.248-5.167 1.00 23.02 A C原子1849 C VAL A 267 15.601 55.532-1.905 1.00 25.54 A C原子1850 O VAL A 267 16.706 56.001-1.621 1.00 29.62 A O原子1851 N GLU A 268 14.752 55.043-1.022 1.00 23.24 A N原子1852 CA GLU A 268 14.944 55.121 0.399 1.00 22.64 A C原子1853 CB GLU A 268 13.602 54.827 1.043 1.00 21.78 A C原子1854 CG GLU A 268 13.440 55.269 2.433 1.00 24.50 A C原子1855 CD GLU A 268 13.797 56.692 2.692 1.00 26.24 A C原子1856 OE1 GLU A 268 13.065 57.580 2.209 1.00 28.07 A O原子1857 OE2 GLU A 268 14.812 56.903 3.396 1.00 27.50 A O原子1858 C GLU A 268 16.046 54.177 0.885 1.00 22.74 A C原子1859 O GLU A 268 16.728 54.475 1.864 1.00 24.12 A O原子1860 N ILE A 269 16.236 53.075 0.155 1.00 23.95 A N
原子1861 CA ILE A 269 17.265 52.064 0.432 1.00 23.66 A C原子1862 CB ILE A 269 16.875 50.668-0.173 1.00 23.47 A C原子1863 CG2 ILE A 269 18.058 49.681-0.147 1.00 22.43 A C原子1864 CG1 ILE A 269 15.710 50.067 0.631 1.00 22.30 A C原子1865 CD1 ILE A 269 15.00748.883-0.035 1.00 20.05 A C原子1866 C ILE A 269 18.596 52.568-0.133 1.00 25.13 A C原子1867 O ILE A 269 19.641 52.465 0.530 1.00 26.08 A O原子1868 N ILE A 270 18.523 53.166-1.327 1.00 25.14 A N原子1869 CA ILE A 270 19.675 53.738-2.023 1.00 23.85 A C原子1870 CB ILE A 270 19.301 54.163-3.502 1.00 24.45 A C原子1871 CG2 ILE A 270 20.390 55.067-4.1240 1.00 22.63 A C原子1872 CG1 ILE A 270 19.123 52.909-4.372 1.00 22.79 A C原子1873 CD1 ILE A 270 18.624 53.160-5.777 1.00 20.24 A C原子1874 C ILE A 270 20.243 54.914-1.218 1.00 24.63 A C原子1875 O ILE A 270 21.468 55.071-1.142 1.00 23.03 A O原子1876 N LYS A 271 19.362 55.669-0.547 1.00 23.96 A N原子1877 CA LYS A 271 19.771 56.820 0.275 1.00 24.69 A C原子1878 CB LYS A 271 18.550 57.542 0.841 1.00 26.54 A C原子1879 CG LYS A 271 17.940 58.618-0.041 1.00 27.03 A C原子1880 CD LYS A 271 16.692 59.194 0.635 1.00 28.96 A C原子1881 CE LYS A 271 16.323 60.601 0.125 1.00 34.13 A C原子1882 NZ LYS A 271 15.887 60.697-1.316 1.00 34.78 A N原子1883 C LYS A 271 20.714 56.458 1.433 1.00 25.82 A C原子1884 O LYS A 271 21.286 57.343 2.065 1.00 29.20 A O原子1885 N VAL A 272 20.849 55.160 1.720 1.00 26.09 A N原子1886 CA VAL A 272 21.726 54.664 2.781 1.00 24.70 A C原子1887 CB VAL A 272 20.912 53.923 3.927 1.00 24.12 A C原子1888 CG1 VAL A 272 21.850 53.291 4.961 1.00 24.21 A C
原子1889 CG2 VAL A 272 20.009 54.902 4.659 1.00 22.10 A C原子1890 C VAL A 272 22.807 53.742 2.199 1.00 24.35 A C原子1891 O VAL A 272 23.996 54.007 2.365 1.00 25.45 A O原子1892 N LEU A 273 22.392 52.682 1.503 1.00 22.66 A N原子1893 CA LEU A 273 23.320 51.703 0.928 1.00 23.33 A C原子1894 CB LEU A 273 22.584 50.400 0.611 1.00 21.78 A C原子1895 CG LEU A 273 21.801 49.616 1.669 1.00 24.90 A C原子1896 CD1 LEU A 273 21.578 48.189 1.191 1.00 21.65 A C原子1897 CD2 LEU A 273 22.547 49.594 2.993 1.00 24.53 A C原子1898 C LEU A 273 24.052 52.158-0.333 1.00 26.01 A C原子1899 O LEU A 273 25.062 51.562-0.735 1.00 26.55 A O原子1900 N GLY A 274 23.506 53.189-0.974 1.00 26.36 A N原子1901 CA GLY A 274 24.075 53.699-2.200 1.00 26.43 A C原子1902 C GLY A 274 23.530 52.920-3.376 1.00 27.76 A C原子1903 O GLY A 274 22.844 51.906-3.198 1.00 26.91 A O原子1904 N THR A 275 23.854 53.389-4.578 1.00 29.66 A N原子1905 CA THR A 275 23.430 52.760-5.827 1.00 33.25 A C原子1906 CB THR A 275 23.924 53.576-7.028 1.00 33.53 A C原子1907 OG1 THR A 275 23.697 54.965-6.765 1.00 36.65 A O原子1908 CG2 THR A 275 23.178 53.176-8.305 1.00 35.68 A C原子1909 C THR A 275 24.003 51.338-5.919 1.00 34.88 A C原子1910 O THR A 275 25.205 51.139-5.698 1.00 32.97 A O原子1911 N PRO A 276 23.129 50.327-6.131 1.00 36.10 A N原子1912 CD PRO A 276 21.654 50.365-6.141 1.00 34.88 A C原子1913 CA PRO A 276 23.611 48.945-6.237 1.00 38.86 A C原子1914 CB PRO A 276 22.318 48.129-6.326 1.00 36.70 A C原子1915 CG PRO A 276 21.306 49.106-6.846 1.00 35.97 A C原子1916 C PRO A 276 24.487 48.759-7.464 1.00 42.29 A C
原子1917 O PRO A 276 24.179 49.290-8.538 1.00 44.40 A O原子1918 N THR A 277 25.602 48.051-7.289 1.00 45.73 A N原子1919 CA THR A 277 26.531 47.799-8.390 1.00 49.94 A C原子1920 CB THR A 277 27.868 47.162-7.914 1.00 49.78 A C原子1921 OG1 THR A 277 27.644 45.806-7.504 1.00 52.18 A O原子1922 CG2 THR A 277 28.473 47.955-6.766 1.00 50.32 A C原子1923 C THR A 277 25.895 46.879-9.431 1.00 52.29 A C原子1924 O THR A 277 24.831 46.294-9.188 1.00 52.29 A O原子1925 N ARG A 278 26.573 46.757-10.573 1.00 55.65 A N原子1926 CA ARG A 278 26.158 45.931-11.713 1.00 57.29 A C原子1927 CB ARG A 278 27.285 45.929-12.759 1.00 62.83 A C原子1928 CG ARG A 278 27.774 47.329-13.194 1.00 69.46 A C原子1929 CD ARG A 278 29.096 47.274-13.987 1.00 74.01 A C原子1930 NE ARG A 278 28.998 46.485-15.219 1.00 79.03 A N原子1931 CZ ARG A 278 28.923 46.989-16.452 1.00 81.31 A C原子1932 NH1 ARG A 278 28.938 48.305-16.657 1.00 82.60 A N原子1933 NH2 ARG A 278 28.792 46.167-17.488 1.00 82.13 A N原子1934 C ARG A 278 25.854 44.490-11.277 1.00 55.48 A C原子1935 O ARG A 278 24.764 43.965-11.539 1.00 53.52 A O原子1936 N GLU A 279 26.792 43.925-10.511 1.00 52.84 A N原子1937 CA GLU A 279 26.717 42.565-9.990 1.00 50.16 A C原子1938 CB GLU A 279 28.122 42.122-9.518 1.00 51.58 A C原子1939 CG GLU A 279 28.277 40.659-9.023 12.00 53.57 A C原子1940 CD GLU A 279 27.807 39.603-10.028 1.00 56.33 A C原子1941 OE1 GLU A 279 27.084 38.670-9.610 1.00 55.45 A O原子1942 OE2 GLU A 279 28.151 39.704-11.230 1.00 58.95 A O原子1943 C GLU A 279 25.667 42.411-8.877 1.00 48.03 A C原子1944 O GLU A 279 25.032 41.351-8.766 1.00 46.34 A O
原子1945 N GLN A 280 25.467 43.473-8.085 1.00 44.34 A N原子1946 CA GLN A 280 24.478 43.461-7.003 1.00 40.87 A C原子1947 CB GLN A 280 24.609 44.702-6.108 1.00 39.68 A C原子1948 CG GLN A 280 25.721 44.589-5.063 1.00 36.03 A C原子1949 CD GLN A 280 25.948 45.871-4.265 1.00 35.25 A C原子1950 OE1 GLN A 280 25.967 46.967-4.819 1.00 35.32 A O原子1951 NE2 GLN A 280 26.160 45.729-2.959 1.00 33.42 A N原子1952 C GLN A 280 23.050 43.300-7.533 1.00 39.21 A C原子1953 O GLN A 280 22.218 42.692-6.872 1.00 36.70 A O原子1954 N ILE A 281 22.805 43.770-8.758 1.00 40.26 A N原子1955 CA ILE A 281 21.494 43.643-9.414 1.00 42.46 A C原子1956 CB ILE A 281 21.37944.494-10.726 1.00 43.27 A C原子1957 CG2 ILE A 281 19.943 44.415-11.305 1.00 43.18 A C原子1958 CG1 ILE A 281 21.829 45.946-10.505 1.00 43.86 A C原子1959 CD1 ILE A 281 20.881 46.812-9.721 1.00 44.42 A C原子1960 C ILE A 281 21.291 42.188-9.834 1.00 43.67 A C原子1961 O ILE A 281 20.235 41.610-9.576 1.00 44.15 A O原子1962 N ARG A 282 22.319 41.617-10.472 1.00 46.57 A N原子1963 CA ARG A 282 22.309 40.238-10.980 1.00 49.33 A C原子1964 CB ARG A 282 23.665 39.896-11.622 1.00 53.32 A C原子1965 CG ARG A 282 23.620 38.777-12.688 1.00 57.88 A C原子1966 CD ARG A 282 23.646 39.317-14.132 1.00 61.04 A C原子1967 NE ARG A 282 22.512 40.191-14.452 1.00 63.02 A N原子1968 CZ ARG A 282 22.617 41.416-14.969 1.00 65.07 A C原子1969 NH1 ARG A 282 23.812 41.936-15.239 1.00 65.14 A N原子1970 NH2 ARG A 282 21.522 42.141-15.184 1.00 64.85 A N原子1971 C ARG A 282 21.957 39.206-9.908 1.00 49.41 A C原子1972 O ARG A 282 21.114 38.328-10.139 1.00 49.71 A O
原子1973 N GLU A 283 22.546 39.370-8.721 1.00 48.54 A N原子1974 CA GLU A 283 22.307 38.477-7.590 1.00 47.57 A C原子1975 CB GLU A 283 23.435 38.609-6.575 1.00 49.61 A C原子1976 CG GLU A 283 24.750 38.066-7.118 1.00 51.95 A C原子1977 CD GLU A 283 25.903 38.221-6.158 1.00 53.45 A C原子1978 OE1 GLU A 283 26.431 37.185-5.706 1.00 54.54 A O原子1979 OE2 GLU A 283 26.290 39.372-5.855 1.00 55.06 A O原子1980 C GLU A 283 20.931 38.667-6.944 1.00 46.54 A C原子1981 O GLU A 283 20.426 37.769-6.267 1.00 44.63 A O原子1982 N MET A 284 20.306 39.811-7.222 1.00 47.59 A N原子1983 CA MET A 284 18.972 40.120-6.713 1.00 49.71 A C原子1984 CB MET A 284 18.807 41.626-6.472 1.00 48.77 A C原子1985 CG MET A 284 19.514 42.119-5.214 1.00 49.31 A C原子1986 SD MET A 284 19.046 43.777-4.689 1.00 49.93 A S原子1987 CE MET A 284 19.994 44.785-5.823 1.00 50.67 A C原子1988 C MET A 284 17.905 39.600-7.677 1.00 51.96 A C原子1989 O MET A 284 16.990 38.879-7.266 1.00 52.27 A O原子1990 N ASN A 285 18.056 39.948-8.957 1.00 53.90 A N原子1991 CA ASN A 285 17.146 39.528-10.028 1.00 55.70 A C原子1992 CB ASN A 285 16.023 40.561-10.234 1.00 56.50 A C原子1993 CG ASN A 285 14.913 40.069-11.168 1.00 57.30 A C原子1994 OD1 ASN A 285 14.139 40.871-11.684 1.00 57.07 A O原子1995 ND2 ASN A 285 14.824 38.754-11.371 1.00 57.03 A N原子1996 C ASN A 285 17.981 39.353-11.310 1.00 56.48 A C原子1997 O ASN A 285 18.445 40.340-11.892 1.00 55.42 A O原子1998 N PRO A 286 18.197 38.089-11.748 1.00 57.65 A N原子1999 CD PRO A 286 17.816 36.855-11.022 1.00 57.96 A C原子2000 CA PRO A 286 18.979 37.756-12.950 1.00 58.42 A C
原子2001 CB PRO A 286 19.145 36.236-12.835 1.00 59.11 A C原子2002 CG PRO A 286 17.913 35.801-12.083 1.00 57.92 A C原子2003 C PRO A 286 18.431 38.176-14.326 1.00 59.68 A C原子2004 O PRO A 286 19.210 38.507-15.231 1.00 59.11 A O原子2005 N ASN A 287 17.106 38.182-14.474 1.00 60.25 A N原子2006 CA ASN A 287 16.478 38.551-15.744 1.00 61.07 A C原子2007 CB ASN A 287 15.240 37.674-16.017 1.00 60.87 A C原子2008 CG ASN A 287 14.239 37.681-14.871 1.00 60.13 A C原子2009 OD1 ASN A 287 14.179 36.735-14.080 1.00 60.26 A O原子2010 ND2 ASN A 287 13.442 38.744-14.784 1.00 58.34 A N原子2011 C ASN A 287 16.155 40.041-15.898 1.00 62.03 A C原子2012 O ASN A 287 15.485 40.438-16.860 1.00 62.85 A O原子2013 N TYR A 288 16.658 40.853-14.966 1.00 62.57 A N原子2014 CA TYR A 288 16.447 42.306-14.972 1.00 64.13 A C原子2015 CB TYR A 288 16.326 42.826-13.528 1.00 61.79 A C原子2016 CG TYR A 288 15.788 44.243-13.382 1.00 60.32 A C原子2017 CD1 TYR A 288 14.394 44.490-13.332 1.00 59.79 A C原子2018 CEL TYR A 288 13.887 45.817-13.192 1.00 59.11 A C原子2019 CD2 TYR A 288 16.668 45.348-13.290 1.00 57.69 A C原子2020 CE2 TYR A 288 16.177 46.669-13.154 1.00 56.95 A C原子2021 CZ TYR A 288 14.792 46.896-13.105 1.00 58.96 A C原子2022 OH TYR A 288 14.325 48.184-12.959 1.00 59.81 A O原子2023 C TYR A 288 17.596 43.023-15.692 1.00 65.78 A C原子2024 O TYR A 288 18.753 42.601-15.601 1.00 67.08 A O原子2025 N THR A 289 17.261 44.122-16.371 1.00 66.83 A N原子2026 CA THR A 289 18.226 44.941-17.105 1.00 69.81 A C原子2027 CB THR A 289 18.476 44.395-18.562 1.00 70.61 A C原子2028 OG1 THR A 289 19.251 43.187-18.499 1.00 70.37 A O
原子2029 CG2 THR A 289 19.209 45.423-19.451 1.00 70.60 A C原子2030 C THR A 289 17.732 46.383-17.172 1.00 71.26 A C原子2031 O THR A 289 16.590 46.645-17.569 1.00 73.06 A O原子2032 N GLU A 290 18.620 47.302-16.794 1.00 71.55 A N原子2033 CA GLU A 290 18.369 48.742-16.808 1.00 72.31 A C原子2034 CB GLU A 290 17.510 49.170-15.582 1.00 70.96 A C原子2035 CG GLU A 290 18.004 50.302-14.639 1.00 71.20 A C原子2036 CD GLU A 290 18.643 49.794-13.337 1.00 70.18 A C原子2037 OE1 GLU A 290 19.380 48.786-13.366 1.00 70.87 A O原子2038 OE2 GLU A 290 18.420 50.416-12.278 1.00 68.63 A O原子2039 C GLU A 290 19.729 49.440-16.884 1.00 74.42 A C原子2040 O GLU A 290 19.982 50.202-17.822 1.00 75.10 A O原子2041 N PHE A 291 20.612 49.105-15.933 1.00 75.92 A N原子2042 CA PHE A 291 21.977 49.649-15.797 1.00 76.83 A C原子2043 CB PHE A 291 22.927 48.997-16.825 1.00 78.67 A C原子2044 CG PHE A 291 23.495 47.661-16.385 1.00 80.61 A C原子2045 CDI PHE A 291 24.826 47.320-16.707 1.00 81.40 A C原子2046 CD2 PHE A 291 22.719 46.738-15.642 1.00 81.26 A C原子2047 CE1 PHE A 291 25.387 46.075-16.297 1.00 81.96 A C原子2048 CE2 PHE A 291 23.261 45.489-15.222 1.00 82.68 A C原子2049 CZ PHE A 291 24.602 45.158-15.552 1.00 82.53 A C原子2050 C PHE A 291 22.108 51.184-15.781 1.00 76.37 A C原子2051 O PHE A 291 23.136 51.744-16.177 1.00 76.51 A O原子2052 N LYS A 292 21.067 51.849-15.278 1.00 75.05 A N原子2053 CA LYS A 292 21.041 53.305-15.195 1.00 73.58 A C原子2054 CB LYS A 292 19.755 53.853-15.832 1.00 74.80 A C原子2055 CG LYS A 292 19.925 55.150-16.654 1.00 75.02 A C原子2056 CD LYS A 292 19.561 56.439-15.895 1.00 76.51 A C
原子2057 CE LYS A 292 18.098 56.468-15.435 1.00 76.47 A C原子2058 NZ LYS A 292 17.776 57.705-14.679 1.00 75.94 A N原子2059 C LYS A 292 21.216 53.777-13.748 1.00 71.73 A C原子2060 O LYS A 292 22.133 53.309-13.060 1.00 71.43 A O原子2061 N PHE A 293 20.338 54.694-13.305 1.00 69.00 A N原子2062 CA PHE A 293 20.325 55.346-11.977 1.00 65.75 A C原子2063 CB PHE A 293 19.973 54.363-10.837 1.00 66.67 A C原子2064 CG PHE A 293 19.050 54.948-9.784 1.00 67.00 A C原子2065 CD1 PHE A 293 17.655 54.814-9.906 1.00 67.27 A C原子2066 CD2 PHE A 293 19.567 55.681-8.694 1.00 67.07 A C原子2067 CE1 PHE A 293 16.775 55.409-8.955 1.00 67.07 A C原子2068 CE2 PHE A 293 18.705 56.287-7.736 1.00 66.86 A C原子2069 CZ PHE A 293 17.306 56.150-7.868 1.00 66.82 A C原子2070 C PHE A 293 21.653 56.084-11.711 1.00 62.49 A C原子2071 O PHE A 293 22.728 55.570-12.056 1.00 62.02 A O原子2072 N PRO A 294 21.602 57.324-11.163 1.00 59.76 A N原子2073 CD PRO A 294 20.457 58.244-10.999 1.00 58.61 A C原子2074 CA PRO A 294 22.857 58.045-10.899 1.00 57.77 A C原子2075 CB PRO A 294 22.364 59.394-10.336 1.00 58.98 A C原子2076 CG PRO A 294 20.930 59.128-9.897 1.00 57.12 A C原子2077 C PRO A 294 23.872 57.348-9.970 1.00 55.35 A C原子2078 O PRO A 294 24.007 56.115-9.965 1.00 53.70 A O原子2079 N GLN A 295 24.675 58.146-9.286 1.00 53.74 A N原子2080 CA GLN A 295 25.640 57.594-8.364 1.00 52.43 A C原子2081 CB GLN A 295 27.060 57.685-8.892 1.00 54.44 A C原子2082 CG GLN A 295 27.602 56.356-9.358 1.00 55.11 A C原子2083 CD GLN A 295 28.004 55.451-8.226 1.00 57.23 A C原子2084 OE1 GLN A 295 27.348 54.443-7.963 1.00 59.23 A O
原子2085 NE2 GLN A 295 29.097 55.797-7.552 1.00 58.58 A N原子2086 C GLN A 295 25.520 58.276-7.048 1.00 50.54 A C原子2087 O GLN A 295 25.817 59.466-6.904 1.00 50.04 A O原子2088 N ILE A 296 24.900 57.533-6.143 1.00 49.44 A N原子2089 CA ILE A 296 24.686 57.958-4.777 1.00 48.83 A C原子2090 CB ILE A 296 23.218 57.731-4.329 1.00 45.74 A C原子2091 CG2 ILE A 296 22.995 58.279-2.918 1.00 47.20 A C原子2092 CG1 ILE A 296 22.225 58.346-5.342 1.00 45.93 A C原子2093 CD1 ILE A 296 22.358 59.862-5.624 1.00 41.55 A C原子2094 C ILE A 296 25.632 57.060-3.998 1.00 49.22 A C原子2095 O ILE A 296 25.631 55.830-4.170 1.00 47.11 A O原子2096 N LYS A 297 26.522 57.695-3.243 1.00 50.72 A N原子2097 CA LYS A 297 27.481 56.957-2.441 1.00 51.94 A C原子2098 CB LYS A 297 28.798 57.736-2.310 1.00 53.90 A C原子2099 CG LYS A 297 30.031 56.871-1.962 1.00 58.32 A C原子2100 CD LYS A 297 30.274 55.681-2.924 1.00 59.47 A C原子2101 CE LYS A 297 30.927 56.090-4.251 1.00 61.75 A C原子2102 NZ LYS A 297 31.287 54.898-5.086 1.00 60.74 A N原子2103 C LYS A 297 26.874 56.610-1.087 1.00 50.71 A C原子2104 O LYS A 297 25.990 57.315-0.587 1.00 50.69 A O原子2105 N ALA A 298 27.304 55.471-0.551 1.00 50.58 A N原子2106 CA ALA A 298 26.836 54.956 0.733 1.00 49.92 A C原子2107 CB ALA A 298 27.491 53.612 1.025 1.00 50.71 A C原子2108 C ALA A 298 27.092 55.913 1.882 1.00 49.11 A C原子2109 O ALA A 298 28.221 56.367 2.078 1.00 49.94 A O原子2110 N HIS A 299 26.015 56.281 2.571 1.00 48.23 A N原子2111 CA HIS A 299 26.075 57.167 3.731 1.00 48.83 A C原子2112 CB HIS A 299 24.661 57.662 4.062 1.00 49.57 A C
原子2113 CG HIS A 299 24.605 58.751 5.092 1.0052.29 A C原子2114 CD2 HIS A 299 25.170 59.981 5.127 1.00 52.86 A C原子2115 ND1 HIS A 299 23.822 58.659 6.224 1.00 53.53.30 A N原子2116 CE1 HIS A 299 23.901 59.786 6.907 1.00 52.43 A C原子2117 NE2 HIS A 299 24.714 60.604 6.264 1.00 54.26 A N原子2118 C HIS A 299 26.634 56.261 4.846 1.00 49.16 A C原子2119 O HIS A 299 26.001 55.249 5.181 1.00 49.39 A O原子2120 N PRO A 300 27.853 56.570 5.378 1.00 48.45 A N原子2121 CD PRO A 300 28.644 57.781 5.091 1.00 46.91 A C原子2122 CA PRO A 300 28.513 55.787 6.442 1.00 47.09 A C原子2123 CB PRO A 300 29.591 56.739 6.975 1.00 47.32 A C原子2124 CG PRO A 300 29.201 58.098 6.429 1.00 48.24 A C原子2125 C PRO A 300 27.617 55.228 7.552 1.00 45.52 A C原子2126 O PRO A 300 26.694 55.897 8.043 1.00 43.48 A O原子2127 N TRP A 301 27.884 53.970 7.887 1.00 44.25 A N原子2128 CA TRP A 301 27.125 53.227 8.882 1.00 43.78 A C原子2129 CB TRP A 301 27.601 51.771 8.931 1.00 44.00 A C原子2130 CG TRP A 301 26.986 50.869 7.857 1.00 45.30 A C原子2131 CD2 TRP A 301 25.597 50.501 7.704 1.00 43.30 A C原子2132 CE2 TRP A 301 25.516 49.631 6.581 1.00 43.83 A C原子2133 CE3 TRP A 301 24.411 50.821 8.400 1.00 43.13 A C原子2134 CD1 TRP A 301 27.660 50.226 6.848 1.00 46.40 A C原子2135 NE1 TRP A 301 26.785 49.482 6.083 1.00 45.93 A N原子2136 CZ2 TRP A 301 24.294 49.073 6.137 1.00 42.32 A C原子2137 CZ3 TRP A 301 23.182 50.263 7.954 1.00 42.11 A C原子2138 CH2 TRP A 301 23.143 49.400 6.831 1.00 40.59 A C原子2139 C TRP A 301 26.983 53.807 10.282 1.00 42.35 A C原子2140 O TRP A 301 26.010 53.512 10.982 1.00 40.29 A O
原子2141 N THR A 302 27.915 54.681 10.652 1.00 41.74 A N原子2142 CA THR A 302 27.898 55.329 11.958 1.00 41.49 A C原子2143 CB THR A 302 29.319 55.526 12.493 1.00 41.53 A C原子2144 OG1 THR A 302 30.159 56.028 11.446 1.00 43.97 A O原子2145 CG2 THR A 302 29.868 54.216 13.003 1.00 42.58 A C原子2146 C THR A 302 27.164 56.670 11.956 1.00 41.40 A C原子2147 O THR A 302 26.928 57.243 13.019 1.00 42.82 A O原子2148 N LYS A 303 26.805 57.161 10.769 1.00 41.27 A N原子2149 CA LYS A 303 26.099 58.434 10.633 1.00 42.22 A C原子2150 CB LYS A 303 26.660 59.253 9.465 1.00 45.05 A C原子2151 CG LYS A 303 28.076 59.800 9.668 1.00 48.74 A C原子2152 CD LYS A 303 28.142 60.875 10.747 1.00 52.10 A C原子2153 CE LYS A 303 29.509 61.539 10.793 1.00 53.01 A C原子2154 NZ LYS A 303 29.757 62.388 9.592 1.00 55.47 A N原子2155 C LYS A 303 24.583 58.283 10.500 1.00 42.12 A C原子2156 O LYS A 303 23.847 59.267 10.643 1.00 42.03 A O原子2157 N VAL A 304 24.124 57.063 10.211 1.00 40.30 A N原子2158 CA VAL A 304 22.688 56.777 10.094 1.00 40.53 A C原子2159 CB VAL A 304 22.386 55.544 9.151 1.00 40.77 A C原子2160 CG1 VAL A 304 23.278 54.379 9.456 1.00 40.85 A C原子2161 CG2 VAL A 304 20.924 55.113 9.227 1.00 41.70 A C原子2162 C VAL A 304 22.113 56.602 11.503 1.00 40.90 A C原子2163 O VAL A 304 20.996 57.042 11.789 1.00 42.47 A O原子2164 N PHE A 305 22.909 56.005 12.385 1.00 39.77 A N原子2165 CA PHE A 305 22.510 55.797 13.769 1.00 38.03 A C原子2166 CB PHE A 305 22.950 54.418 14.260 1.00 35.95 A C原子2167 CG PHE A 305 22.404 53.279 13.449 1.00 32.65 A C原子2168 CD1 PHE A 305 21.036 52.959 13.491 1.00 33.20 A C
原子2169 CD2 PHE A 305 23.251 52.528 12.618 1.00 32.70 A C原子2170 CE1 PHE A 305 20.507 51.903 12.710 1.00 30.62 A C原子2171 CE2 PHE A 305 22.744 51.464 11.826 1.00 31.75 A C原子2172 CZ PHE A 305 21.363 51.154 11.874 1.00 32.22 A C原子2173 C PHE A 305 23.139 56.884 14.625 1.00 39.55 A C原子2174 O PHE A 305 24.211 57.397 14.299 1.00 39.69 A O原子2175 N ARG A 306 22.468 57.219 15.727 1.00 41.25 A N原子2176 CA ARG A 306 22.910 58.248 16.671 1.00 43.59 A C原子2177 CB ARG A 306 21.818 58.430 17.745 1.00 43.64 A C原子2178 CG ARG A 306 21.524 57.196 18.597 1.00 44.87 A C原子2179 CD ARG A 306 20.314 57.378 19.515 1.00 47.95 A C原子2180 NE ARG A 306 20.130 56.224 20.405 1.00 48.19 A N原子2181 CZ ARG A 306 20.553 56.166 21.670 1.00 48.40 A C原子2182 NH1 ARG A 306 21.188 57.195 22.215 1.00 48.42 A N原子2183 NH2 ARG A 306 20.364 55.068 22.388 1.00 45.82 A N原子2184 C ARG A 306 24.267 57.880 17.316 1.00 45.34 A C原子2185 O ARG A 306 24.664 56.714 17.271 1.00 44.67 A O原子2186 N PRO A 307 25.041 58.869 17.834 1.00 47.15 A N原子2187 CD PRO A 307 24.982 60.343 17.754 1.00 47.97 A C原子2188 CA PRO A 307 26.311 58.446 18.446 1.00 48.12 A C原子2189 CB PRO A 307 27.026 59.775 18.731 1.00 48.01 A C原子2190 CG PRO A 307 25.908 60.757 18.876 1.00 48.71 A C原子2191 C PRO A 307 26.040 57.645 19.721 1.00 48.30 A C原子2192 O PRO A 307 24.901 57.596 20.203 1.00 50.01 A O原子2193 N ARG A 308 27.072 56.978 20.229 1.00 48.83 A N原子2194 CA ARG A 308 26.985 56.139 21.433 1.00 49.80 A C原子2195 CB ARG A 308 26.571 56.953 22.687 1.00 52.05 A C原子2196 CG ARG A 308 27.509 58.147 23.019 1.00 54.22 A C
原子2197 CD ARG A 308 28.764 57.762 23.806 1.00 57.43 A C原子2198 NE ARG A 308 28.612 57.968 25.252 1.00 59.09 A N原子2199 CZ ARG A 308 29.448 58.678 26.015 1.00 60.62 A C原子2200 NH1 ARG A 308 30.516 59.266 25.484 1.00 61.71 A N原子2201 NH2 ARG A 308 29.215 58.809 27.319 1.00 60.15 A N原子2202 C ARG A 308 26.140 54.855 21.234 1.00 48.81 A C原子2203 O ARG A 308 25.914 54.095 22.177 1.00 48.97 A O原子2204 N THR A 309 25.715 54.615 19.984 1.00 46.95 A N原子2205 CA THR A 309 24.971 53.406 19.579 1.00 43.38 A C原子2206 CB THR A 309 24.320 53.564 18.141 1.00 42.89 A C原子2207 OG1 THR A 309 23.233 54.491 18.199 1.00 41.63 A O原子2208 CG2 THR A 309 23.785 52.231 17.587 1.00 41.95 A C原子2209 C THR A 309 26.071 52.333 19.515 1.00 40.81 A C原子2210 O THR A 309 27.112 52.572 18.896 1.00 41.04 A O原子2211 N PRO A 310 25.878 51.167 20.181 1.00 39.14 A N原子2212 CD PRO A 310 24.769 50.805 21.087 1.00 38.13 A C原子2213 CA PRO A 310 26.881 50.090 20.175 1.00 37.91 A C原子2214 CB PRO A 310 26.142 48.939 20.851 1.00 35.79 A C原子2215 CG PRO A 310 25.349 49.636 21.859 1.00 37.87 A C原子2216 C PRO A 310 27.436 49.690 18.799 1.00 37.77 A C原子2217 O PRO A 310 26.664 49.418 17.868 1.00 35.62 A O原子2218 N PRO A 311 28.786 49.730 18.637 1.00 37.56 A N原子2219 CD PRO A 311 29.756 50.273 19.614 1.00 36.69 A C原子2220 CA PRO A 311 29.482 49.376 17.389 1.00 35.84 A C原子2221 CB PRO A 311 30.951 49.447 17.799 1.00 35.19 A C原子2222 CG PRO A 311 30.960 50.577 18.749 1.00 36.48 A C原子2223 C PRO A 311 29.115 47.986 16.851 1.00 34.34 A C原子2224 O PRO A 311 29.062 47.764 15.636 1.00 34.96 A O
原子2225 N GLU A 312 28.795 47.081 17.768 1.00 33.05 A N原子2226 CA GLU A 312 28.411 45.716 17.425 1.00 32.11 A C原子2227 CB GLU A 312 28.514 44.811 18.654 1.00 34.52 A C原子2228 CG GLU A 312 29.641 45.161 19.630 1.00 37.63 A C原子2229 CD GLU A 312 29.151 45.985 20.827 1.00 42.08 A C原子2230 OE1 GLU A 312 28.191 45.537 21.505 1.00 43.26 A O原子2231 OE2 GLU A 312 29.732 47.067 21.098 1.00 40.84 A O原子2232 C GLU A 312 26.989 45.670 16.844 1.00 29.46 A C原子2233 O GLU A 312 26.666 44.778 16.073 1.00 28.20 A O原子2234 N ALA A 313 26.164 46.664 17.186 1.00 29.26 A N原子2235 CA ALA A 313 24.776 46.761 16.692 1.00 28.36 A C原子2236 CB ALA A 313 23.986 47.756 17.538 1.00 26.03 A C原子2237 C ALA A 313 24.761 47.186 15.225 1.00 27.13 A C原子2238 O ALA A 313 24.043 46.613 14.395 1.00 27.48 A O原子2239 N ILE A 314 25.616 48.161 14.930 1.00 24.41 A N原子2240 CA ILE A 314 25.802 48.717 13.606 1.00 23.22 A C原子2241 CB ILE A 314 26.745 49.947 13.665 1.00 22.88 A C原子2242 CG2 ILE A 314 26.912 50.547 12.295 1.00 20.78 A C原子2243 CG1 ILE A 314 26.178 50.998 14.621 1.00 20.70 A C原子2244 CD1 ILE A 314 27.172 52.058 15.035 1.00 25.96 A C原子2245 C ILE A 314 26.397 47.639 12.703 1.00 22.09 A C原子2246 O ILE A 314 25.922 47.440 11.582 1.00 22.62 A O原子2247 N ALA A 315 27.388 46.914 13.228 1.00 22.17 A N原子2248 CA ALA A 315 28.069 45.837 12.496 1.00 21.80 A C原子2249 CB ALA A 315 29.246 45.294 13.303 1.00 23.07 A C原子2250 C ALA A 315 27.097 44.716 12.142 1.00 21.81 A C原子2251 O ALA A 315 27.113 44.205 11.015 1.00 21.35 A O原子2252 N LEU A 316 26.202 44.381 13.079 1.00 23.17 A N
原子2253 CA LEU A 316 25.196 43.355 12.807 1.00 23.10 A C原子2254 CB LEU A 316 24.378 42.999 14.046 1.00 20.49 A C原子2255 CG LEU A 316 23.225 41.994 13.839 1.00 18.83 A C原子2256 CD1 LEU A 316 23.696 40.642 13.326 1.00 20.59 A C原子2257 CD2 LEU A 316 22.457 41.835 15.104 1.00 17.79 A C原子2258 C LEU A 316 24.280 43.851 11.697 1.00 24.38 A C原子2259 O LEU A 316 24.041 43.130 10.735 1.00 25.32 A O原子2260 N CYS A 317 23.892 45.122 11.775 1.00 25.36 A N原子2261 CA CYS A 317 23.016 45.705 10.778 1.00 28.75 A C原子2262 CB CYS A 317 22.626 47.116 11.179 1.00 31.11 A C原子2263 SG CYS A 317 21.332 47.759 10.160 1.00 33.71 A S原子2264 C CYS A 317 23.623 45.692 9.379 1.00 29.89 A C原子2265 O CYS A 317 22.940 45.339 8.412 1.00 29.61 A O原子2266 N SER A 318 24.927 45.966 9.295 1.00 30.12 A N原子2267 CA SER A 318 25.633 45.972 8.014 1.00 31.04 A C原子2268 CB SER A 318 27.062 46.515 8.171 1.00 32.40 A C原子2269 OG SER A 318 27.894 45.646 8.916 1.00 37.10 A O原子2270 C SER A 318 25.640 44.598 7.338 1.00 30.58 A C原子2271 O SER A 318 25.556 44.502 6.113 1.00 32.71 A O原子2272 N ARG A 319 25.682 43.544 8.146 1.00 29.61 A N原子2273 CA ARG A 319 25.668 42.187 7.628 1.00 30.36 A C原子2274 CB ARG A 319 26.593 41.292 8.451 1.00 34.56 A C原子2275 CG ARG A 319 28.096 41.484 8.179 1.00 40.63 A C原子2276 CD ARG A 319 28.568 40.843 6.858 1.00 47.97 A C原子2277 NE ARG A 319 28.184 41.600 5.661 1.00 53.18 A N原子2278 CZ ARG A 319 28.445 41.240 4.402 1.00 57.45 A C原子2279 NH1 ARG A 319 29.106 40.117 4.129 1.00 59.71 A N原子2280 NH2 ARG A 319 28.033 42.010 3.402 1.00 59.71 A N
原子2281 C ARG A 319 24.260 41.590 7.478 1.00 29.92 A C原子2282 O ARG A 319 24.098 40.384 7.263 1.00 28.71 A O原子2283 N LEU A 320 23.246 42.456 7.566 1.00 30.59 A N原子2284 CA LEU A 320 21.838 42.071 7.407 1.00 28.72 A C原子2285 CB LEU A 320 21.028 42.381 8.660 1.00 29.26 A C原子2286 CG LEU A 320 21.327 41.635 9.957 1.00 31.05 A C原子2287 CD1 LEU A 320 20.504 42.219 11.072 1.00 32.16 A C原子2288 CD2 LEU A 320 21.092 40.149 9.815 1.00 31.46 A C原子2289 C LEU A 320 21.258 42.870 6.270 1.00 28.07 A C原子2290 O LEU A 320 20.582 42.329 5.388 1.00 28.47 A O原子2291 N LEU A 321 21.529 44.173 6.309 1.00 27.98 A N原子2292 CA LEU A 321 21.046 45.098 5.299 1.00 26.38 A C原子2293 CB LEU A 321 20.654 46.459 5.914 1.00 21.14 A C原子2294 CG LEU A 321 19.485 46.516 6.917 1.00 17.19 A C原子2295 CD1 LEU A 321 19.185 47.942 7.328 1.00 10.82 A C原子2296 CD2 LEU A 321 18.235 45.906 6.324 1.00 18.88 A C原子2297 C LEU A 321 21.989 45.254 4.111 1.00 27.46 A C原子2298 O LEU A 321 22.505 46.338 3.834 1.00 28.05 A O原子2299 N GLU A 322 22.205 44.143 3.418 1.00 28.61 A N原子2300 CA GLU A 322 23.034 44.127 2.225 1.00 31.24 A C原子2301 CB GLU A 322 24.266 43.216 2.389 1.00 34.15 A C原子2302 CG GLU A 322 25.607 43.843 1.922 1.00 39.62 A C原子2303 CD GLU A 322 25.616 44.289 0.445 1.00 44.43 A C原子2304 OE1 GLU A 322 25.363 45.492 0.162 1.00 43.55 A O原子2305 OE2 GLU A 322 25.854 43.425-0.431 1.00 46.30 A O原子2306 C GLU A 322 22 186 43.657 1.043 1.00 31.28 A C原子2307 O GLU A 322 21.335 42.763 1.181 1.00 31.25 A O原子2308 N TYR A 323 22.462 44.253-0.120 1.00 30.59 A N
原子2309 CA TYR A 323 21.788 43.957-1.383 1.00 27.98 A C原子2310 CB TYR A 323 22.389 44.796-2.503 1.00 26.77 A C原子2311 CG TYR A 323 21.913 46.227-2.543 1.00 26.75 A C原子2312 CD1 TYR A 323 20.546 46.526-2.710 1.00 27.23 A C原子2313 CE1 TYR A 323 20.087 47.864-2.786 1.00 26.14 A C原子2314 CD2 TYR A 323 22.824 47.299-2.450 1.00 25.50 A C原子2315 CE2 TYR A 323 22.376 48.641-2.526 1.00 27.00 A C原子2316 CZ TYR A 323 21.001 48.908-2.692 1.00 24.56 A C原子2317 OH TYR A 323 20.540 50.197-2.756 1.00 24.65 A O原子2318 C TYR A 323 21.863 42.499-1.771 1.00 28.42 A C原子2319 O TYR A 323 20.830 41.878-1.990 1.00 29.46 A O原子2320 N THR A 324 23.091 41.965-1.809 1.00 28.83 A N原子2321 CA THR A 324 23.395 40.568-2.154 1.00 29.36 A C原子2322 CB THR A 324 24.955 40.361-2.202 1.00 31.12 A C原子2323 OG1 THR A 324 25.536 41.304-3.110 1.00 34.26 A O原子2324 CG2 THR A 324 25.342 38.942-2.638 1.00 29.15 A C原子2325 C THR A 324 22.744 39.649-1.103 1.00 27.97 A C原子2326 O THR A 324 23.127 39.686 0.059 1.00 30.82 A O原子2327 N PRO A 325 21.735 38.843-1.497 1.00 27.81 A N原子2328 CD PRO A 325 21.209 38.737-2.871 1.00 28.41 A C原子2329 CA PRO A 325 21.006 37.919-0.604 1.00 27.26 A C原子2330 CB PRO A 325 20.017 37.230-1.547 1.00 27.65 A C原子2331 CG PRO A 325 19.822 38.212-2.634 1.00 28.72 A C原子2332 C PRO A 325 21.847 36.886 0.145 1.00 27.99 A C原子2333 O PRO A 325 21.712 36.735 1.369 1.00 25.28 A O原子2334 N THR A 326 22.738 36.218-0.594 1.00 28.22 A N原子2335 CA THR A 326 23.638 35.194-0.046 1.00 28.20 A C原子2336 CB THR A 326 24.268 34.315-1.173 1.00 29.04 A C
原子2337 OG1 THR A 326 25.096 35.127-2.017 1.00 28.94 A O原子2338 CG2 THR A 326 23.175 33.633-2.026 1.00 26.65 A C原子2339 C THR A 326 24.757 35.772 0.845 1.00 27.68 A C原子2340 O THR A 326 25.501 35.009 1.489 1.00 26.85 A O原子2341 N ALA A 327 24.874 37.106 0.872 1.00 25.97 A N原子2342 CA ALA A 327 25.875 37.789 1.708 1.00 26.96 A C原子2343 CB ALA A 327 26.389 39.067 1.051 1.00 25.07 A C原子2344 C ALA A 327 25.312 38.107 3.089 1.00 27.09 A C原子2345 O ALA A 327 26.065 38.417 4.020 1.00 24.79 A O原子2346 N ARG A 328 23.980 38.060 3.201 1.00 28.34 A N原子2347 CA ARG A 328 23.292 38.318 4.465 1.00 26.61 A C原子2348 CB ARG A 328 21.799 38.547 4.256 1.00 25.56 A C原子2349 CG ARG A 328 21.450 39.765 3.444 1.00 25.90 A C原子2350 CD ARG A 328 19.961 39.810 3.199 1.00 22.23 A C原子2351 NE ARG A 328 19.673 40.511 1.957 1.00 22.11 A N原子2352 CZ ARG A 328 18.578 40.353 1.227 1.00 22.06 A C原子2353 NH1 ARG A 328 17.620 39.518 1.596 1.00 24.48 A N原子2354 NH2 ARG A 328 18.477 40.987 0.077 1.00 23.49 A N原子2355 C ARG A 328 23.470 37.102 5.337 1.00 25.96 A C原子2356 O ARG A 328 23.532 35.979 4.839 1.00 27.07 A O原子2357 N LEU A 329 23.553 37.342 6.639 1.00 27.31 A N原子2358 CA LEU A 329 23.718 36.291 7.631 1.00 25.55 A C原子2359 CB LEU A 329 23.948 36.904 9.012 1.00 25.84 A C原子2360 CG LEU A 329 25.215 37.715 9.232 1.00 26.07 A C原子2361 CD1 LEU A 329 25.229 38.269 10.639 1.00 25.95 A C原子2362 CD2 LEU A 329 26.437 36.861 8.998 1.00 26.33 A C原子2363 C LEU A 329 22.472 35.449 7.705 1.00 25.21 A C原子2364 O LEU A 329 21.376 35.937 7.454 1.00 25.29 A O
原子2365 N THR A 330 22.648 34.172 8.030 1.00 26.30 A N原子2366 CA THR A 330 21.518 33.267 8.190 1.00 23.67 A C原子2367 CB THR A 330 21.945 31.767 8.133 1.00 24.57 A C原子2368 OG1 THR A 330 22.516 31.375 9.394 1.00 25.26 A O原子2369 CG2 THR A 330 22.907 31.509 6.977 1.00 23.23 A C原子2370 C THR A 330 21.052 33.599 9.609 1.00 23.65 A C原子2371 O THR A 330 21.816 34.201 10.382 1.00 23.44 A O原子2372 N PRO A 331 19.791 33.268 9.959 1.00 24.00 A N原子2373 CD PRO A 331 18.669 32.781 9.123 1.00 21.51 A C原子2374 CA PRO A 331 19.312 33.561 11.313 1.00 23.30 A C原子2375 CB PRO A 331 17.970 32.867 11.329 1.00 23.67 A C原子2376 CG PRO A 331 17.494 33.048 9.969 1.00 22.76 A C原子2377 C PRO A 331 20.218 33.054 12.437 1.00 23.42 A C原子2378 O PRO A 331 20.474 33.785 13.393 1.00 25.23 A O原子2379 N LEU A 332 20.768 31.847 12.265 1.00 25.53 A N原子2380 CA LEU A 332 21.672 31.228 13.247 1.0025.04 A C原子2381 CB LEU A 332 21.950 29.759 12.915 1.0025.54 A C原子2382 CG LEU A 332 21.263 28.576 13.616 1.0027.38 A C原子2383 CD1 LEU A 332 22.299 27.453 13.749 1.00 24.16 A C原子2384 CD2 LEU A 332 20.722 28.921 15.003 1.00 25.32 A C原子2385 C LEU A 332 22.999 31.955 13.355 1.00 24.53 A C原子2386 O LEU A 332 23.546 32.100 14.442 1.00 25.49 A O原子2387 N GLU A 333 23.498 32.429 12.224 1.00 26.96 A N原子2388 CA GLU A 333 24.761 33.164 12.182 1.00 32.56 A C原子2389 CB GLU A 333 25.208 33.374 10.729 1.00 33.46 A C原子2390 CG GLU A 333 25.584 32.083 10.017 1.00 35.64 A C原子2391 CD GLU A 333 26.067 32.299 8.596 1.00 39.68 A C原子2392 OE1 GLU A 333 27.008 31.585 8.183 1.00 40.69 A O
原子2393 OE2 GLU A 333 25.503 33.163 7.885 1.00 40.82 A O原子2394 C GLU A 333 24.561 34.497 12.887 1.00 33.10 A C原子2395 O GLU A 333 25.413 34.948 13.663 1.00 33.77 A O原子2396 N ALA A 334 23.366 35.053 12.679 1.00 34.71 A N原子2397 CA ALA A 334 22.945 36.318 13.272 1.00 32.79 A C原子2398 CB ALA A 334 21.638 36.737 12.686 1.00 33.12 A C原子2399 C ALA A 334 22.846 36.167 14.785 1.00 31.49 A C原子2400 O ALA A 334 23.345 37.008 15.512 1.00 31.13 A O原子2401 N CYS A 335 22.289 35.043 15.240 1.00 30.01 A N原子2402 CA CYS A 335 22.170 34.724 16.668 1.00 28.69 A C原子2403 CB CYS A 335 21.452 33.393 16.843 1.00 28.08 A C原子2404 SG CYS A 335 19.687 33.454 17.012 1.00 31.20 A S原子2405 C CYS A 335 23.558 34.598 17.311 1.00 28.97 A C原子2406 O CYS A 335 23.758 34.976 18.467 1.00 27.56 A O原子2407 N ALA A 336 24.515 34.120 16.512 1.00 28.87 A N原子2408 CA ALA A 336 25.891 33.904 16.947 1.00 28.10 A C原子2409 CB ALA A 336 26.514 32.780 16.138 1.00 28.21 A C原子2410 C ALA A 336 26.778 35.140 16.907 1.00 28.39 A C原子2411 O ALA A 336 27.938 35.079 17.321 1.00 29.86 A O原子2412 N HIS A 337 26.220 36.258 16.437 1.00 27.79 A N原子2413 CA HIS A 337 26.929 37.538 16.340 1.00 25.93 A C原子2414 CB HIS A 337 26.058 38.559 15.585 1.00 26.12 A C原子2415 CG HIS A 337 26.749 39.855 15.280 1.00 27.57 A C原子2416 CD2 HIS A 337 27.314 40.314 14.138 1.00 24.19 A C原子2417 ND1 HIS A 337 26.974 40.823 16.237 1.00 25.30 A N原子2418 CE1 HIS A 337 27.656 41.818 15.701 1.00 23.12 A C原子2419 NE2 HIS A 337 27.872 41.535 14.428 1.00 26.35 A N原子2420 C HIS A 337 27.303 38.071 17.731 1.00 27.28 A C
原子2421 O HIS A 337 26.595 37.822 18.719 1.00 26.23 A O原子2422 N SER A 338 28.391 38.847 17.773 1.00 27.62 A N原子2423 CA SER A 338 28.917 39.429 19.007 1.00 27.81 A C原子2424 CB SER A 338 30.314 40.014 18.782 1.00 27.03 A C原子2425 OG SER A 338 30.265 41.231 18.059 1.00 32.03 A O原子2426 C SER A 338 28.020 40.456 19.694 1.00 27.51 A C原子2427 O SER A 338 28.282 40.841 20.844 1.00 29.60 A O原子2428 N PHE A 339 26.973 40.900 18.997 1.00 23.94 A N原子2429 CA PHE A 339 26.024 41.860 19.562 1.00 23.11 A C原子2430 CB PHE A 339 25.100 42.416 18.467 1.00 22.52 A C原子2431 CG PHE A 339 24.016 43.347 18.970 1.00 19.21 A C原子2432 CD1 PHE A 339 22.666 43.075 18.675 1.00 17.00 A C原子2433 CD2 PHE A 339 24.343 44.524 19.696 1.00 17.34 A C原子2434 CE1 PHE A 339 21.635 43.966 19.082 1.00 16.11 A C原子2435 CE2 PHE A 339 23.341 45.427 20.117 1.00 13.86 A C原子2436 CZ PHE A 339 21.977 45.155 19.806 1.00 18.48 A C原子2437 C PHE A 339 25.196 41.186 20.656 1.00 22.18 A C原子2438 O PHE A 339 24.739 41.844 21.570 1.00 22.78 A O原子2439 N PHE A 340 25.048 39.872 20.567 1.00 22.67 A N原子2440 CA PHE A 340 24.276 39.123 21.546 1.00 23.49 A C原子2441 CB PHE A 340 23.452 38.051 20.838 1.00 21.00 A C原子2442 CG PHE A 340 22.544 38.597 19.787 1.00 22.12 A C原子2443 CD1 PHE A 340 21.371 39.297 20.141 1.00 19.33 A C原子2444 CD2 PHE A 340 22.856 38.438 18.423 1.00 22.58 A C原子2445 CE1 PHE A 340 20.513 39.835 19.146 1.00 13.87 A C原子2446 CE2 PHE A 340 21.998 38.974 17.416 1.00 19.37 A C原子2447 CZ PHE A 340 20.826 39.672 17.788 1.00 17.95 A C原子2448 C PHE A 340 25.107 38.502 22.665 1.00 24.37 A C
原子2449 O PHE A 340 24.596 37.659 23.407 1.00 23.70 A O原子2450 N ASP A 341 26.362 38.950 22.819 1.00 25.46 A N原子2451 CA ASP A 341 27.266 38.410 23.855 1.00 25.43 A C原子2452 CB ASP A 341 28.716 38.883 23.661 1.00 24.12 A C原子2453 CG ASP A 341 29.452 38.104 22.573 1.00 21.89 A C原子2454 OD1 ASP A 341 29.045 36.972 22.243 1.00 19.83 A O原子2455 OD2 ASP A 341 30.439 38.636 22.027 1.00 21.39 A O原子2456 C ASP A 341 26.824 38.626 25.293 1.00 26.72 A C原子2457 O ASP A 341 27.002 37.737 26.125 1.00 27.88 A O原子2458 N GLU A 342 26.165 39.761 25.553 1.00 28.64 A N原子2459 CA GLU A 342 25.638 40.103 26.883 1.00 29.30 A C原子2460 CB GLU A 342 24.992 41.496 26.863 1.00 30.64 A C原子2461 CG GLU A 342 24.751 42.102 28.252 1.00 31.79 A C原子2462 CD GLU A 342 24.045 43.456 28.247 1.00 33.12 A C原子2463 OE1 GLU A 342 23.962 44.133 27.189 1.00 32.04 A O原子2464 OE2 GLU A 342 23.568 43.846 29.337 1.00 35.06 A O原子2465 C GLU A 342 24.596 39.056 27.322 1.00 29.07 A C原子2466 O GLU A 342 24.503 38.713 28.503 1.00 29.80 A O原子2467 N LEU A 343 23.880 38.505 26.342 1.00 28.35 A N原子2468 CA LEU A 343 22.853 37.488 26.577 1.00 28.37 A C原子2469 CB LEU A 343 21.985 37.338 25.333 1.00 26.38 A C原子2470 CG LEU A 343 20.724 38.175 25.137 1.00 24.83 A C原子2471 CD1 LEU A 343 20.800 39.562 25.751 1.00 23.95 A C原子2472 CD2 LEU A 343 20.438 38.221 23.658 1.00 23.33 A C原子2473 C LEU A 343 23.417 36.129 26.969 1.00 28.43 A C原子2474 O LEU A 343 22.717 35.314 27.560 1.00 28.03 A O原子2475 N ARG A 344 24.690 35.912 26.652 1.00 30.54 A N原子2476 CA ARG A 344 25.384 34.660 26.956 1.00 33.48 A C
原子2477 CB ARG A 344 26.256 34.252 25.768 1.00 31.55 A C原子2478 CG ARG A 344 25.459 33.677 24.613 1.00 29.17 A C原子2479 CD ARG A 344 26.330 33.406 23.412 1.00 28.28 A C原子2480 NE ARG A 344 26.735 34.634 22.729 1.00 28.30 A N原子2481 CZ ARG A 344 26.197 35.069 21.590 1.00 28.60 A C原子2482 NH1 ARG A 344 25.230 34.377 20.996 1.00 26.79 A N原子2483 NH2 ARG A 344 26.604 36.213 21.055 1.00 27.56 A N原子2484 C ARG A 344 26.203 34.717 28.257 1.00 35.95 A C原子2485 O ARG A 344 26.701 33.690 28.739 1.00 36.48 A O原子2486 N ASP A 345 26.288 35.918 28.835 1.00 38.09 A N原子2487 CA ASP A 345 27.001 36.183 30.090 1.00 40.69 A C原子2488 CB ASP A 345 27.062 37.708 30.298 1.00 43.13 A C原子2489 CG ASP A 345 27.959 38.128 31.455 1.00 45.65 A C原子2490 ODE ASP A 345 27.655 3.778 32.615 1.00 48.79 A O原子2491 OD2 ASP A 345 28.950 38.849 31.207 1.00 48.78 A O ATOM.2492 C ASP A 345 26.20735.50431.2311.0040.75 A C原子2493 O ASP A 345 24.985 35.602 31.261 1.00 41.05 A O原子2494 N PRO A 346 26.888 34.801 32.169 1.00 40.50 A N原子2495 CD PRO A 346 28.337 34.519 32.240 1.00 40.27 A C原子2496 CA PRO A 346 26.184 34.132 33.277 1.00 39.85 A C原子2497 CB PRO A 346 27.320 33.479 34.061 1.00 39.63 A C原子2498 CG PRO A 346 28.379 33.268 33.054 1.00 40.55 A C原子2499 C PRO A 346 25.392 35.069 34.197 1.00 40.57 A C原子2500 O PRO A 346 24.360 34.675 34.755 1.00 39.40 A O原子2501 N ASN A 347 25.858 36.315 34.302 1.00 41.45 A N原子2502 CA ASN A 347 25.246 37.328 35.169 1.00 43.97 A C原子2503 CB ASN A 347 26.359 38.102 35.907 1.00 45.59 A C原子2504 CG ASN A 347 27.424 37.181 36.507 1.00 47.23 A C原子2505 OD1 ASN A 347 28.618 37.338 36.235 1.00 47.48 A O
原子2506 ND2 ASN A 347 26.989 36.193 37.291 1.00 46.71 A N原子2507 C ASN A 347 24.313 38.289 34.408 1.00 44.21 A C原子2508 O ASN A 347 24.292 39.500 34.670 1.00 44.66 A O原子2509 N VAL A 348 23.522 37.711 33.499 1.00 43.66 A N原子2510 CA VAL A 348 22.560 38.402 32.628 1.00 42.37 A C原子2511 CB VAL A 348 21.701 37.382 31.835 1.00 44.63 A C原子2512 CG1 VAL A 348 22.387 36.978 30.564 1.00 44.29 A C原子2513 CG2 VAL A 348 21.326 36.157 32.704 1.00 45.37 A C原子2514 C VAL A 348 21.606 39.450 33.230 1.00 41.89 A C原子2515 O VAL A 348 21.909 40.647 33.224 1.00 43.60 A O原子2516 N LYS A 349 20.455 38.980 33.723 1.00 40.05 A N原子2517 CA LYS A 349 19.376 39.769 34.340 1.00 39.12 A C原子2518 CB LYS A 349 19.777 40.327 35.716 1.00 39.09 A C原子2519 CG LYS A 349 20.201 39.288 36.747 1.00 42.20 A C原子2520 CD LYS A 349 19.148 38.221 36.998 1.00 43.56 A C原子2521 CE LYS A 349 19.675 37.187 37.976 1.00 45.21 A C原子2522 NZ LYS A 349 18.720 36.067 38.160 1.00 48.86 A N原子2523 C LYS A 349 18.682 40.863 33.533 1.00 38.10 A C原子2524 O LYS A 349 19.314 41.738 32.927 1.00 37.45 A O原子2525 N LEU A 350 17.353 40.809 33.569 1.00 36.56 A N原子2526 CA LEU A 350 16.510 41.798 32.910 1.00 34.72 A C原子2527 CB LEU A 350 15.088 41.244 32.741 1.00 31.52 A C原子2528 CG LEU A 350 14.845 39.963 31.938 1.00 29.74 A C原子2529 CD1 LEU A 350 13349 39.704 31.841 1.00 29.61 A C原子2530 CD2 LEU A 350 15.457 40.050 30.568 1.00 24.93 A C原子2531 C LEU A 350 16.489 43.014 33.849 1.00 34.43 A C原子2532 O LEU A 350 16.720 42.849 35.053 1.00 34.97 A O原子2533 N PRO A 351 16.268 44.246 33.322 1.00 33.99 A N
原子2534 CD PRO A 351 16.296 44.614 31.890 1.00 33.98 A C原子2535 CA PRO A 351 16.225 45.466 34.146 1.00 34.03 A C原子2536 CB PRO A 351 15.798 46.522 33.146 1.00 35.34 A C原子2537 CG PRO A 351 16.557 46.102 31.938 1.00 36.02 A C原子2538 C PRO A 351 15.295 45.446 35.363 1.00 36.05 A C原子2539 O PRO A 351 15.386 46.326 36.227 1.00 36.69 A O原子2540 N ASN A 352 14.439 44.421 35.432 1.00 35.67 A N原子2541 CA ASN A 352 13.496 44.229 36.527 1.00 34.99 A C原子2542 CB ASN A 352 12.070 44.049 35.974 1.00 34.88 A C原子2543 CG ASN A 352 11.869 42.745 35.183 1.00 34.90 A C原子2544 OD1 ASN A 352 12.812 42.011 34.894 1.00 33.67 A O原子2545 ND2 ASN A 352 10.614 42.456 34.853 1.00 35.20 A N原子2546 C ASN A 352 13.898 43.082 37.476 1.00 36.87 A C原子2547 O ASN A 352 13.059 42.520 38.185 1.00 37.32 A O原子2548 N GLY A 353 15.176 42.706 37.432 1.00 38.73 A N原子2549 CA GLY A 353 15.701 41.655 38.294 1.00 39.34 A C原子2550 C GLY A 353 15.462 40.212 37.889 1.00 41.09 A C原子2551 O GLY A 353 16.219 39.321 38.305 1.00 40.79 A O原子2552 N ARG A 354 14.409 39.979 37.100 1.00 42.00 A N原子2553 CA ARG A 354 14.037 38.644 36.611 1.00 42.20 A C原子2554 CB ARG A 354 12.721 38.713 35.834 1.00 44.15 A C原子2555 CG ARG A 354 11.489 38.961 36.667 1.00 47.59 A C原子2556 CD ARG A 354 10.268 39.072 35.777 1.00 48.26 A C原子2557 NE ARG A 354 9.183 38.207 36.232 1.00 52.92 A N原子2558 CZ ARG A 354 7.958 38.622 36.554 1.00 53.77 A C原子2559 NH1 ARG A 354 7.634 39.912 36.478 1.00 54.10 A N原子2560 NH2 ARG A 354 7.051 37.736 36.947 1.00 52.64 A N原子2561 C ARG A 354 15.076 37.995 35.695 1.00 42.26 A C
原子2562 O ARG A 354 15.971 38.669 35.155 1.00 43.19 A O原子2563 N ASP A 355 14.929 36.684 35.504 1.00 41.33 A N原子2564 CA ASP A 355 15.810 35.917 34.626 1.00 39.84 A C原子2565 CB ASP A 355 15.654 34.412 34.873 1.00 39.06 A C原子2566 CG ASP A 355 16.682 33.861 35.837 1.00 40.57 A C原子2567 OD1 ASP A 355 17.569 34.621 36.290 1.00 40.69 A O原子2568 OD2 ASP A 355 16.611 32.647 36.131 1.00 40.22 A O原子2569 C ASP A 355 15.454 36.201 33.178 1.00 37.90 A C原子2570 O ASP A 355 14.374 36.708 32.879 1.00 36.61 A O原子2571 N THR A 356 16.384 35.902 32.283 1.00 35.96 A N原子2572 CA THR A 356 16.154 36.079 30.859 1.00 34.24 A C原子2573 CB THR A 356 17.461 36.012 3D.080 1.00 33.41 A C原子2574 OG1 THR A 356 18.172 34.817 30.439 1.00 35.40 A O原子2575 CG2 THR A 356 18.276 37.225 30.354 1.00 34.32 A C原子2576 C THR A 356 15.334 34.879 30.444 1.00 33.23 A C原子2577 O THR A 356 15.353 33.858 31.146 1.00 34.34 A O原子2578 N PRO A 357 14.564 34.981 29.339 1.00 31.33 A N原子2579 CD PRO A 357 14.121 36.135 28.532 1.00 30.35 A C原子2580 CA PRO A 357 13.805 33.785 28.970 1.00 30.39 A C原子2581 CB PRO A 357 12.898 34293 27.851 1.00 29.53 A C原子2582 CG PRO A 357 13.620 35.474 27.297 1.00 29.44 A C原子2583 C PRO A 357 14.748 32.672 28.490 1.00 29.76 A C原子2584 0 PRO A 357 15.980 32.814 28.564 1.00 28.76 A O原子2585 N ALA A 358 14.162 31.545 28.096 1.00 29.88 A N原子2586 CA ALA A 358 14.906 30.403 27.574 1.00 31.14 A C原子2587 CB ALA A 358 13.951 29.251 27.306 1.00 33.79 A C原子2588 C ALA A 358 15.507 30.905 26.269 1.00 31.85 A C原子2589 O ALA A 358 14.794 31.470 25.431 1.00 35.64 A O
原子2590 N LEU A 359 16.826 30.851 26.171 1.00 28.86 A N原子2591 CA LEU A 359 17.509 31.342 24.985 1.00 29.84 A C原子2592 CB LEU A 359 18.344 32.580 25.336 1.00 29.99 A C原子2593 CG LEU A 359 17.733 33.872 25.904 1.00 32.52 A C原子2594 CD1 LEU A 359 18.840 34.878 26.155 1.00 30.47 A C原子2595 CD2 LEU A 359 16.661 34.448 24.993 1.00 28.48 A C原子2596 C LEU A 359 18.447 30.313 24.408 1.00 31.82 A C原子2597 O LEU A 359 18.994 30.490 23.302 1.00 32.46 A O原子2598 N PHE A 360 18.667 29.247 25.173 1.00 31.89 A N原子2599 CA PHE A 360 19.628 28.233 24.780 1.00 31.61 A C原子2600 CB PHE A 360 20.800 28.257 25.767 1.00 31.56 A C原子2601 CG PHE A 360 21.321 29.645 26.056 1.00 30.67 A C原子2602 CD1 PHE A 360 21.253 30.172 27.354 1.00 30.88 A C原子2603 CD2 PHE A 360 21.845 30.448 25.022 1.00 31.67 A C原子2604 CE1 PHE A 360 21.705 31.493 27.633 1.00 31.64 A C原子2605 CE2 PHE A 360 22.295 31.767 25.278 1.00 32.88 A C原子2606 CZ PHE A 360 22.224 32.290 26.594 1.00 31.45 A C原子2607 C PHE A 360 19.146 26.819 24.531 1.00 31.34 A C原子2608 O PHE A 360 19.917 25.991 24.039 1.00 33.51 A O原子2609 N ASN A 361 17.863 26.566 24.774 1.00 30.04 A N原子2610 CA ASN A 361 17.257 25.248 24.562 1.00 30.01 A C原子2611 CB ASN A 361 15.922 25.158 25.326 1.00 30.57 A C原子2612 CG ASN A 361 15.021 26.386 25.120 1.00 33.81 A C原子2613 OD1 ASN A 361 15.501 27.509 24.962 1.00 33.89 A O原子2614 ND2 ASN A 361 13.706 26.169 25.148 1.00 33.68 A N原子2615 C ASN A 361 17.097 24.850 23.069 1.00 31.99 A C原子2616 O ASN A 361 15.989 24.585 22.596 1.00 34.16 A O原子2617 N PHE A 362 18.221 24.800 22.348 1.00 31.99 A N
原子2618 CA PHE A 362 18.266 24.452 20.919 1.00 33.58 A C原子2619 CB PHE A 362 19.620 24.847 20.292 1.00 31.94 A C原子2620 CG PHE A 362 19.789 26.329 20.035 1.00 31.80 A C原子2621 CD1 PHE A 362 20.505 27.140 20.945 1.00 33.02 A C原子2622 CD2 PHE A 362 19.264 26.921 18.868 1.00 30.18 A C原子2623 CE1 PHE A 362 20.701 28.533 20.699 1.00 31.76 A C原子2624 CE2 PHE A 362 19.445 28.313 18.599 1.00 29.91 A C原子2625 CZ PHE A 362 20.168 29.123 19.520 1.00 31.28 A C原子2626 C PHE A 362 18.021 22.974 20.604 1.00 35.07 A C原子2627 O PHE A 362 18.567 22.082 21.247 1.00 36.71 A O原子2628 N THR A 363 17.211 22.742 19.581 1.00 37.25 A N原子2629 CA THR A 363 16.885 21.407 19.092 1.00 39.86 A C原子2630 CB THR A 363 15.392 21.369 18.610 1.00 39.85 A C原子2631 OG1 THR A 363 14.536 21.648 19.723 1.00 40.62 A O原子2632 CG2 THR A 363 14.989 19.999 18.050 1.00 43.82 A C原子2633 C THR A 363 17.862 21.164 17.930 1.00 41.16 A C原子2634 O THR A 363 18.531 22.103 17.478 1.00 43.39 A O原子2635 N THR A 364 17.985 19.909 17.491 1.00 41.31 A N原子2636 CA THR A 364 18.857 19.539 16.374 1.00 41.08 A C原子2637 CB THR A 364 19.061 18.010 16.298 1.00 43.82 A C原子2638 OG1 THR A 364 17.805 17.341 16.481 1.00 47.82 A O原子2639 CG2 THR A 364 20.038 17.553 17.380 1.00 44.21 A C原子2640 C THR A 364 18.297 20.079 15.057 1.00 39.64 A C原子2641 O THR A 364 19.052 20.392 14.137 1.00 39.67 A O原子2642 N GLN A 365 16.976 20.263 15.020 1.00 40.75 A N原子2643 CA GLN A 365 16.255 20.820 13.864 1.00 41.65 A C原子2644 CB GLN A 365 14.736 20.677 14.072 1.00 40.80 A C原子2645 CG GLN A 365 13.822 21.264 12.975 1.00 41.31 A C
原子2646 CD GLN A 365 13.736 20.433 11.694 1.00 40.91 A C原子2647 OE1 GLN A 365 14.283 19.331 11.593 1.00 43.99 A O原子2648 NE2 GLN A 365 13.029 20.964 10.713 1.00 39.51 A N原子2649 C GLN A 365 16.637 22.299 13.703 1.00 42.27 A C原子2650 O GLN A 365 16.798 22.773 12.588 1.00 43.60 A O原子2651 N GLU A 366 16.821 22.996 14.828 1.00 42.28 A N原子2652 CA GLU A 366 17.216 24.410 14.844 1.00 43.46 A C原子2653 CB GLU A 366 17.073 24.996 16.242 1.00 44.68 A C原子2654 CG GLU A 366 15.678 25.305 16.684 1.00 46.61 A C原子2655 CD GLU A 366 15.674 26.085 17.977 1.00 46.39 A C原子2656 OE1 GLU A 366 15.980 27.299 17.941 1.00 45.22 A O原子2657 OE2 GLU A 366 15.365 25.485 19.026 1.00 48.69 A O原子2658 C GLU A 366 18.676 24.575 14.447 1.00 43.55 A C原子2659 O GLU A 366 19.085 25.619 13.932 1.00 44.87 A O原子2660 N LEU A 367 19.454 23.541 14.738 1.00 42.42 A N原子2661 CA LEU A 367 20.872 23.515 14.449 1.00 42.72 A C原子2662 CB LEU A 367 21.593 22.734 15.547 1.00 44.58 A C原子2663 CG LEU A 367 22.495 23.442 16.567 1.00 44.63 A C原子2664 CD1 LEU A 367 21.984 24.813 17.016 1.00 43.17 A C原子2665 CD2 LEU A 367 22.633 22.510 17.752 1.00 46.66 A C原子2666 C LEU A 367 21.198 22.931 13.086 1.00 42.45 A C原子2667 O LEU A 367 22.330 23.056 12.630 1.00 40.12 A O原子2668 N SER A 368 20.186 22.381 12.401 1.00 43.40 A N原子2669 CA SER A 368 20.356 21.762 11.072 1.00 42.65 A C原子2670 CB SER A 368 19.095 20.981 10.662 1.00 43.28 A C原子2671 OG SER A 368 17.978 21.828 10.473 1.00 43.81 A O原子2672 C SER A 368 20.795 22.720 9.958 1.00 42.18 A C原子2673 O SER A 368 20.852 22.349 8.783 1.00 43.92 A O
原子2674 N SER A 369 21.107 23.951 10.354 1.00 40.82 A N原子2675 CA SER A 369 21.589 24.997 9.460 1.00 38.06 A C原子2676 CB SER A 369 21.049 26.360 9.902 1.00 36.55 A C原子2677 OG SER A 369 21.750 27.415 9.265 1.00 36.86 A O原子2678 C SER A 369 23.109 25.004 9.566 1.00 36.24 A C原子2679 O SER A 369 23.810 25.232 8.584 1.00 33.99 A O原子2680 N ASN A 370 23.595 24.760 10.782 1.00 37.20 A N原子2681 CA ASN A 370 25.022 24.760 11.085 1.00 37.99 A C原子2682 CB ASN A 370 25.523 26.215 11.049 1.00 39.63 A C原子2683 CG ASN A 370 27.017 26.327 10.950 1.00 40.91 A C原子2684 OD1 ASN A 370 27.761 25.661 11.669 1.00 42.76 A O原子2685 ND2 ASN A 370 27.475 27.219 10.085 1.00 43.93 A N原子2686 C ASN A 370 25.226 24.168 12.491 1.00 37.29 A C原子2687 O ASN A 370 25.091 24.886 13.483 1.00 36.34 A O原子2688 N PRO A 371 25.474 22.837 12.603 1.00 37.92 A N原子2689 CD PRO A 371 25.151 21.738 11.668 1.00 37.00 A C原子2690 CA PRO A 371 25.677 22.295 13.957 1.00 38.12 A C原子2691 CB PRO A 371 25.607 20.779 13.743 1.00 36.53 A C原子2692 CG PRO A 371 24.640 20.667 12.619 1.00 35.64 A C原子2693 C PRO A 371 26.921 22.789 14.755 1.00 40.21 A C原子2694 O PRO A 371 26.825 22.899 15.985 1.00 42.81 A O原子2695 N PRO A 372 28.085 23.092 14.095 1.00 40.62 A N原子2696 CD PRO A 372 28.562 22.603 12.783 1.00 40.82 A C原子2697 CA PRO A 372 29.255 23.581 14.852 1.00 40.90 A C原子2698 CB PRO A 372 30.360 23.578 13.798 1.00 40.63 A C原子2699 CG PRO A 372 30.031 22.396 13.014 1.00 41.29 A C原子2700 C PRO A 372 29.113 24.981 15.483 1.00 41.12 A C原子2701 O PRO A 372 30.025 25.455 16.176 1.00 40.90 A O
原子2702 N LEU A 373 27.993 25.653 15.206 1.00 41.11 A N原子2703 CA LEU A 373 27.731 26.977 15.782 1.00 40.39 A C原子2704 CB LEU A 373 26.765 27.801 14.923 1.00 38.71 A C原子2705 CG LEU A 373 27.343 28.693 13.819 1.00 38.73 A C原子2706 CD1 LEU A 373 26.201 29.491 13.231 1.00 39.93 A C原子2707 CD2 LEU A 373 28.450 29.634 14.297 1.00 37.22 A C原子2708 C LEU A 373 27.200 26.877 17.209 1.00 38.50 A C原子2709 O LEU A 373 27.171 27.876 17.932 1.00 36.70 A O原子2710 N ALA A 374 26.864 25.648 17.617 1.00 37.57 A N原子2711 CA ALA A 374 26.342 25.338 18.948 1.00 36.57 A C原子2712 CB ALA A 374 25.970 23.864 19.045 1.00 35.33 A C原子2713 C ALA A 374 27.325 25.705 20.051 1.00 36.53 A C原子2714 O ALA A 374 26.909 26.095 21.142 1.00 36.38 A O原子2715 N THR A 375 28.621 25.645 19.738 1.00 36.46 A N原子2716 CA THR A 375 29.670 25.981 20.700 1.00 39.15 A C原子2717 CB THR A 375 31.066 25.481 20.240 1.00 39.99 A C原子2718 OG1 THR A 375 31.249 25.756 18.847 1.00 42.40 A O原子2719 CG2 THR A 375 31.204 23.978 20.485 1.00 39.43 A C原子2720 C THR A 375 29.706 27.472 21.059 1.00 39.85 A C原子2721 O THR A 375 30.147 27.841 22.151 1.00 41.78 A O原子2722 N ILE A 376 29.201 28.316 20.157 1.00 40.30 A N原子2723 CA ILE A 376 29.142 29.759 20.399 1.00 40.61 A C原子2724 CB ILE A 376 29.401 30.613 19.114 1.00 43.21 A C原子2725 CG2 ILE A 376 29.454 32.110 19.477 1.00 43.37 A C原子2726 CG1 ILE A 376 30.726 30.208 18.451 1.00 44.28 A C原子2727 CD1 ILE A 376 31.011 30.896 17.113 1.00 47.26 A C原子2728 C ILE A 376 27.752 30.077 20.923 1.00 39.70 A C原子2729 O ILE A 376 27.609 30.877 21.849 1.00 41.57 A O
原子2730 N LEU A 377 26.748 29.411 20.349 1.00 36.93 A N原子2731 CA LEU A 377 25.345 29.596 20.704 1.00 35.17 A C原子2732 CB LEU A 377 24.457 28.861 19.714 1.00 35.83 A C原子2733 CG LEU A 377 24.286 29.461 18.322 1.00 35.42 A C原子2734 CD1 LEU A 377 23.478 28.504 17.491 1.00 32.72 A C原子2735 CD2 LEU A 377 23.610 30.807 18.399 1.00 35.31 A C原子2736 C LEU A 377 24.943 29.183 22.108 1.00 35.42 A C原子2737 0 LEU A 377 24.166 29.880 22.763 1.00 35.78 A O原子2738 N ILE A 378 25.414 28.010 22.527 1.00 35.05 A N原子2739 CA ILE A 378 25.139 27.467 23.857 1.00 33.16 A C原子2740 CB ILE A 378 24.758 25.946 23.790 1.00 32.63 A C原子2741 CG2 ILE A 378 24.365 25.418 25.187 1.00 33.68 A C原子2742 CG1 ILE A 378 23.581 25.736 22.826 1.00 32.69 A C原子2743 CD1 ILE A 378 23.462 24.332 22.234 1.00 28.71 A C原子2744 C ILE A 378 26.406 27.683 24.704 1.00 32.26 A C原子2745 O ILE A 378 27.372 26.929 24.583 1.00 34.21 A O原子2746 N PRO A 379 26.426 28.738 25.548 1.00 32.35 A N原子2747 CD PRO A 379 25.319 29.692 25.762 1.00 31.13 A C原子2748 CA PRO A 379 27.556 29.083 26.422 1.00 32.80 A C原子2749 CB PRO A 379 27.141 30.467 26.950 1.00 31.77 A C原子2750 CG PRO A 379 25.672 30.342 27.053 1.00 30.94 A C原子2751 C PRO A 379 27.768 28.041 27.558 1.00 33.22 A C原子2752 O PRO A 379 26.833 27.306 27.902 1.00 30.92 A O原子2753 N PRO A 380 28.987 27.974 28.150 1.00 34.30 A N原子2754 CD PRO A 380 30.180 28.786 27.852 1.00 35.46 A C原子2755 CA PRO A 380 29.313 27.027 29.232 1.00 35.89 A C原子2756 CB PRO A 380 30.618 27.594 29.805 1.00 36.70 A C原子2757 CG PRO A 380 30.725 28.998 29.224 1.00 38.77 A C
原子2758 C PRO A 380 28.292 26.723 30.338 1.00 36.41 A C原子2759 O PRO A 380 28.005 25.550 30.609 1.00 35.01 A O原子2760 N HIS A 381 27.705 27.770 30.917 1.00 35.63 A N原子2761 CA HIS A 381 26.727 27.632 31.996 1.00 35.85 A C原子2762 CB HIS A 381 26.475 28.994 32.654 1.00 36.20 A C原子2763 CG HIS A 381 25.954 30.036 31.713 1.00 37.76 A C原子2764 CD2 HIS A 381 26.591 30.826 30.817 1.00 37.18 A C原子2765 ND1 HIS A 381 24.613 30.350 31.619 1.00 37.12 A N原子2766 CE1 HIS A 381 24.448 31.290 30.706 1.00 39.74 A C原子2767 NE2 HIS A 381 25.633 31.596 30.205 1.00 40.39 A N原子2768 C HIS A 381 25.394 26.990 31.593 1.00 36.29 A C原子2769 O HIS A 381 24.667 26.488 32.450 1.00 36.09 A O原子2770 N ALA A 382 25.080 27.030 30.297 1.00 37.15 A N原子2771 CA ALA A 382 23.834 26.466 29.754 1.00 37.39 A C原子2772 CB ALA A 382 23.301 27.359 28.648 1.00 35.23 A C原子2773 C ALA A 382 24.044 25.046 29.228 1.00 37.85 A C原子2774 O ALA A 382 23.087 24.311 28.973 1.00 37.21 A O原子2775 N ARG A 383 25.318 24.685 29.087 1.00 39.37 A N原子2776 CA ARG A 383 25.768 23.381 28.609 1.00 40.62 A C原子2777 CB ARG A 383 27.270 23.460 28.314 1.00 40.00 A C原子2778 CG ARG A 383 27.793 22.612 27.183 1.00 39.15 A C原子2779 CD ARG A 383 28.239 23.474 26.007 1.00 40.27 A C原子2780 NE ARG A 383 29.193 24.534 26.360 1.00 42.31 A N原子2781 CZ ARG A 383 30.096 25.051 25.521 1.00 44.20 A C原子2782 NH1 ARG A 383 30.199 24.605 24.273 1.00 45.71 A N原子2783 NH2 ARG A 383 30.853 26.072 25.902 1.00 43.13 A N原子2784 C ARG A 383 25.528 22.351 29.711 1.00 41.86 A C原子2785 O ARG A 383 25.967 22.547 30.848 1.00 41.28 A O
原子2786 N ILE A 384 24.747 21.320 29.398 1.00 42.60 A N原子2787 CA ILE A 384 24.466 20.250 30.354 1.00 44.95 A C原子2788 CB ILE A 384 23.082 20.414 31.102 1.00 47.12 A C原子2789 CG2 ILE A 384 23.246 21.301 32.352 1.00 45.31 A C原子2790 CG1 ILE A 384 21.974 20.899 30.150 1.00 50.65 A C原子2791 CD1 ILE A 384 20.565 20.958 30.769 1.00 52.17 A C原子2792 C ILE A 384 24.573 18.861 29.717 1.00 46.94 A C原子2793 OXT ILE A 384 23.875 18.610 28.706 1.00 49.13 A O TER 2794 ILE A 384 A原子2795 C1 911 1-2.099 39.361 19.377 1.00 17.41 C原子2796 C2 911 1-1.979 39.019 20.788 1.00 20.21 C原子2797 N3 911 1-1.929 40.019 21.737 1.00 21.52 N原子2798 C4 911 1-1.978 41.354 21.249 1.00 19.29 C原子2799 C5 911 1-1.911 42.725 21.889 1.00 24.54 C原子2800 N6 911 1-2.070 43.075 20.531 1.00 22.53 N原子2801 C7 911 1-2.243 43.935 19.596 1.00 23.36 C原子2802 N8 911 1-1.899 37.700 21.143 1.00 22.23 N原子2803 C9 911 1-1.917 36.693 20.195 1.00 18.35 C原子2804 C10 911 1-2.028 37.007 18.799 1.00 19.23 C原子2805 C11 911 1-2.037 35.981 17.807 1.00 23.00 C原子2806 N12 911 1-2.025 35.075 16.923 1.00 25.04 N原子2807 C13 911 1-2.125 38.354 18.401 1.00 16.13 C原子2808 N14 911 1-2.259 43.201 18.496 1.00 22.90 N原子2809 C15 911 1-2.448 43.663 17.308 1.00 24.02 C原子2810 C16 911 1-2.414 42.601 16.345 1.00 20.01 C原子2811 C17 911 1-2.679 45.103 17.166 1.00 25.88 C原子2812 C18 911 1-2.981 45.761 15.949 1.00 31.01 C原子2813 C19 911 1-2.634 45.884 18.413 1.00 23.65 C原子2814 N20 911 1-2.410 45.265 19.642 1.00 22.85 N
原子2815 N21 911 1-3.237 47.094 15.837 1.00 37.37 N原子2816 C22 911 1-3.469 47.300 14.486 1.00 39.18 C原子2817 C23 911 1-3.804 48.625 13.840 1.00 42.96 C原子2818 C24 911 1-3.339 46.119 13.860 1.00 37.75 C原子2819 N25 911 1-3.050 45.200 14.719 1.00 33.10 N原子2820 C26 911 1-1.126 42.051 15.987 1.00 20.71 C原子2821 C27 911 1-1.022 40.974 15.056 1.00 17.60 C原子2822 C28 911 1-2.205 40.428 14.461 1.00 18.33 C原子2823 CL29 911 1-2.081 39.096 13.330 1.00 5.54 C L原子2824 C30 911 1-3.492 40.965 14.806 1.00 15.33 C原子2825 C31 911 1-3.614 42.044 15.740 1.00 16.68 C原子2826 CL32 911 1-5.228 42.619 16.119 1.00 7.38 C L原子2827 OH2 TIP 1 3.519 32.951-3.643 1.00 16.57 S O原子2828 OH2 TIP 2-18.111 34.312 1.385 1.00 34.33 S O原子2829 OH2 TIP 3-1.193 48.777 16.143 1.00 38.40 S O原子2830 OH2 TIP 4 13.184 47.448 2.829 1.00 29.56 S O原子2831 OH2 TIP 5 29.406 40.325 27.491 1.00 44.55 S O原子2832 OH2 TIP 6 8.229 53.016 15.458 1.00 26.00 S O原子2833 OH2 TIP 7 0.809 46.462 17.029 1.00 31.42 S O原子2834 OH2 TIP 8 4.554 27.748 17.918 1.00 40.42 S O原子2835 OH2 TIP 9 15.156 19.575 8.017 1.00 32.18 S O原子2836 OH2 TIP 10 12.974 58.863-0.966 1.00 45.47 S O原子2837 OH2 TIP 11 25.259 42.433 31.980 1.00 35.93 S O原子2838 OH2 TIP 12 2.502 47.199 2.432 1.00 24.60 S O原子2839 OH2 TIP 13 9.794 59.038 1.375 1.00 34.46 S O原子2840 OH2 TIP 14 30.784 50.185 13.673 1.00 21.33 S O原子2841 OH2 TIP 15 17.922 26.780 7.702 1.00 50.73 S O原子2842 OH2 TIP 16 12.447 49.743 9.377 1.00 27.99 S O
原子2843 OH2 TIP 17 19.653 29.633 9.895 1.00 39.28 S O原子2844 OH2 TIP 18 5.263 48.916 5.860 1.00 37.92 S O原子2845 OH2 TIP 19 27.306 50.429 3.066 1.00 27.70 S O原子2846 OH2 TIP 20 28.550 60.003-5.780 1.00 27.04 S O原子2847 OH2 TIP 21 3.716 29.276 26.107 1.00 29.15 S O原子2848 OH2 TIP 22-4.637 22.872 22.808 1.00 34.86 S O原子2849 OH2 TIP 23-22.724 28.516 20.421 1.00 58.97 S O原子2850 OH2 TIP 24 11.898 32.240 25.009 1.00 42.27 S O原子2851 OH2 TIP 25 9.885 46.950 28.465 1.00 47.15 S O原子2852 OH2 TIP 26 14.656 21.994 3.898 1.00 34.95 S O原子2853 OH2 TIP 27 16.119 29.366 1.375 1.00 18.85 S O原子2854 OH2 TIP 28-1.175 43.756 12.788 1.00 20.87 S O原子2855 OH2 TIP 29 2.705 49.548 25.939 1.00 39.70 S O原子2856 OH2 TIP 30 11.096 52.150 17.509 1.00 33.83 S O原子2857 OH2 TIP 31 5.232 29.294 21.937 1.00 18.19 S O原子2858 OH2 TIP 32 4.210 33.455-8.903 1.00 30.20 S O原子2859 OH2 TIP 33-14.937 35.158-0.996 1.00 43.25 S O原子2860 OH2 TIP 34-20.626 37.458 8.527 1.00 39.12 S O原子2861 OH2 TIP 35 0.060 22.680 20.356 1.00 45.34 S O原子2862 OH2 TIP 36-0.585 41.816 10.715 1.00 57.14 S O原子2863 OH2 TIP 37 1.539 42.459 3.563 1.00 53.49 S O原子2864 OH2 TIP 38 22.817 53.174-18.209 1.00 35.74 S O原子2865 OH2 TIP 39 26.969 32.150 0.631 1.00 41.90 S O原子2866 OH2 TIP 40 30.263 38.603 15.589 1.00 29.00 S O原子2867 OH2 TIP 41-3.722 29.682-7.880 1.00 59.47 S O原子2868 OH2 TIP 42-10.540 29.580 5.124 1.00 32.15 S O原子2869 OH2 TIP 43 6.128 50.604 11.404 1.00 40.65 S O原子2870 OH2 TIP 44 16.996 24.052-8.701 1.00 35.66 S O
原子2871 OH2 TIP 45-5.648 24.571 24.933 1.00 51.50 S O原子2872 OH2 TIP 46 21.102 19.443 21.075 1.00 42.64 S O原子2873 OH2 TIP 47 16.818 15.091 18.344 1.00 33.39 S O原子2874 OH2 TIP 48 33.965 41.827 17.984 1.00 43.11 S O原子2875 OH2 TIP 49-2.829 32.638 30.155 1.00 47.14 S O原子2876 OH2 TIP 50 26.053 15.853 28.335 1.00 38.68 S O原子2877 OH2 TIP 51-2.836 21.590 20.631 1.00 41.84 S O原子2878 OH2 TIP 52-5.951 29.665 0.033 1.00 51.25 S O原子2879 OH2 TIP 53 11.107 40.852-13.765 1.00 41.02 S O原子2880 OH2 TIP 54 8.201 30.682 26.083 1.00 60.19 S O原子2881 OH2 TIP 55 1.449 42.290-0.483 1.00 62.54 S O原子2882 OH2 TIP 56 26.221 60.218 14.193 1.00 42.92 S O原子2883 OH2 TIP 57 21.366 56.675-19.108 1.00 49.21 S O原子2884 OH2 TIP 58 8.709 44.602-9.430 1.00 34.08 S O原子2885 OH2 TIP 59-4.612 46.703 21.968 1.00 37.46 S O原子2886 OH2 TIP 60 31.785 41.035 14.348 1.00 32.88 S O原子2887 OH2 TIP 61 11.831 49.560-9.633 1.00 40.70 S O原子2888 OH2 TIP 62 17.518 35.393-3.198 1.00 31.18 S O原子2889 OH2 TIP 63 20.516 53.304 19.364 1.00 45.42 S O原子2890 OH2 TIP 64-22.615 35.186 24.758 1.00 52.22 S O原子2891 OH2 TIP 65 0.408 61.513 20.076 1.00 48.52 S O原子2892 OH2 TIP 66 20.504 44.688 31.823 1.00 40.03 S O原子2893 OH2 TIP 67 5.080 38.325-8.727 1.00 34.83 S O原子2894 OH2 TIP 68-21.340 29.171 17.542 1.00 61.07 S O原子2895 OH2 TIP 69 30.060 42.039 12.713 1.00 33.64 S O原子2896 OH2 TIP 70 17.771 51.244 20.977 1.00 39.82 S O原子2897 OH2 TIP 71 31.991 61.399 8.053 1.00 35.67 S O原子2898 OH2 TIP 72 31.347 64.436 10.848 1.00 43.21 S O
原子2899 OH2 TIP 73 12.674 24.093 19.580 1.00 48.39 S O原子2900 OH2 TIP 74 27.536 44.279 28.770 1.00 43.90 S O原子2901 OH2 TIP 75 4.035 56.178 16.097 1.00 44.11 S O原子2902 OH2 TIP 76 27.362 53.320-4.698 1.00 39.13 S O原子2903 OH2 TIP 77 0.491 45.431-0.343 1.00 49.14 S O原子2904 OH2 TIP 78-11.443 45.826 11.620 1.00 34.98 S O原子2905 OH2 TIP 79-19.009 42.127 24.662 1.00 52.17 S O原子2906 OH2 TIP 80 22.891 56.639-15.103 1.00 40.03 S O原子2907 OH2 TIP 81 9.151 24.039 22.182 1.00 43.64 S O原子2908 OH2 TIP 82-1.776 52.715 13.965 1.00 50.14 S O原子2909 OH2 TIP 83-7.798 30.645 3.978 1.00 37.72 S O原子2910 OH2 TIP 84 27.677 42.444 23.407 1.00 39.63 S O原子2911 OH2 TIP 85 11.367 31.300-10.613 1.00 52.86 S O原子2912 OH2 TIP 86 18.405 31.450 6.151 1.00 32.72 S O原子2913 OH2 TIP 87 9.812 39.158 5.604 1.00 42.35 S O原子2914 OH2 TIP 88-6.643 26.256-5.266 1.00 56.86 S O原子2915 OH2 TIP 89 14.190 33.188-12.189 1.00 60.28 S O原子2916 OH2 TIP 90 18.734 57.743 16.298 1.00 65.11 S O原子2917 OH2 TIP 91 17.145 57.024 7.052 1.00 42.35 S O原子2918 OH2 TIP 92 2.583 35.112 27.158 1.00 47.01 S O原子2919 OH2 TIP 93 15.189 63.271 23.577 1.00 33.86 S O原子2920 OH2 TIP 94 29.354 54.037 21.318 1.00 53.67 S O原子2921 OH2 TIP 95 13.884 29.677-3.710 1.00 58.47 S O原子2922 OH2 TIP 96 25.590 46.649 3.859 1.00 50.68 S O原子2923 OH2 TIP 97 26.641 55.372 15.719 1.00 66.43 S O原子2924 OH2 TIP 98 1.793 39.753-6.157 1.00 52.77 S O原子2925 OH2 TIP 99 6.173 34.524 29.142 1.00 46.48 S O原子2926 OH2 TIP 100 2.019 55.519 22.653 1.00 44.21 S O
原子2927 OH2 TIP 101 9.034 20.561 18.446 1.00 24.12 S O原子2928 OH2 TIP 102-12.287 38.499 8.791 1.00 38.64 S O原子2929 OH2 TIP 103-6.409 33.685 0.777 1.00 52.36 S O原子2930 OH2 TIP 104-15.886 35.262 17.514 1.00 38.58 S O原子2931 OH2 TIP 105 14.952 17.778 20.539 1.00 30.44 S O原子2932 OH2 TIP 106 13.389 49.661 31.461 1.00 34.32 S O原子2933 OH2 TIP 107 32.372 53.573 9.559 1.00 36.19 S O原子2934 OH2 TIP 108 4.214 25.589 20.488 1.00 49.34 S O原子2935 OH2 TIP 109-0.552 40.396 2.427 1.00 59.78 S O原子2936 OH2 TIP 110-15.298 40.078 6.709 1.00 45.34 S O原子2937 OH2 TIP 111 18.225 34.787-8.197 1.00 27.76 S O原子2938 OH2 TIP 112-0.146 35.717 28.427 1.00 42 11 S O原子2939 OH2 TIP 113 7.679 39.515-10.847 1.00 31.78 S O原子2940 OH2 TIP 114 16.984 16.913 12.972 1.00 67.85 S O原子2941 OH2 TIP 115 8.712 19.014 2.872 1.00 42.52 S O原子2942 OH2 TIP 116 8.198 44.158 34.086 1.00 37.02 S O原子2943 OH2 TIP 117-2.910 15.830 11.287 1.00 34.31 S O原子2944 OH2 TIP 118-1.997 32.068 26.939 1.00 48.52 S O原子2945 OH2 TIP 119 9.831 57.462 9.164 1.00 28.90 S O原子2946 OH2 TIP 120-25.333 29.208 1.643 1.00 58.81 S O原子2947 OH2 TIP 121 8.099 20.459 5.865 1.00 41.51 S O原子2948 OH2 TIP 122 8.436 19.165 22.385 1.00 59.09 S O原子2949 OH2 TIP 123-11.153 43.854 9.021 1.00 45.74 S O原子2950 OH2 TIP 124-16.926 40.898 20.693 1.00 40.45 S O原子2951 OH2 TIP 125 0.330 50.583-4.589 1.00 42.01 S O原子2952 OH2 TIP 126 23.399 32.516 22.014 1.00 31.76 S O原子2953 OH2 TIP 127-3.095 27.693 33.779 1.00 68.72 S O原子2954 OH2 TIP 128 25.582 59.602 24.776 1.00 50.29 S O
原子2955 OH2 TIP 129 30.932 45.342-18.901 1.00 49.88 S O原子2956 OH2 TIP 130 2.858 52.418 4.564 1.00 41.54 S O原子2957 OH2 TIP 131-10.955 41.110 1.222 1.00 38.13 S O原子2958 OH2 TIP 132 5.205 25.733-1.653 1.00 39.47 S O原子2959 OH2 TIP 133 12.520 47.868 35.531 1.00 46.04 S O原子2960 OH2 TIP 134 18.467 58.591 9.998 1.00 66.38 S O原子2961 OH2 TIP 135-1.657 34.133 1.341 1.00 32.64 S O原子2962 OH2 TIP 136-5.273 48.189 18.164 1.00 75.53 S O原子2963 OH2 TIP 137-15.495 10.770 19.235 1.00 67.03 S O原子2964 OH2 TIP 138-6.986 49.629 10.903 1.00 31.16 S O原子2965 OH2 TIP 139 10.825 22.412-9.270 1.00 52.63 S O原子2966 OH2 TIP 140 14.242 23.401-2.089 1.00 47.93 S O原子2967 OH2 TIP 141 4.219 36.375 37.389 1.00 37.71 S O原子2968 OH2 TIP 142 16.169 20.549 23.367 1.00 38.34 S O原子2969 OH2 TIP 143-19.832 29.214-1.120 1.00 63.68 S O原子2970 OH2 TIP 144 16.587 63.221 1.845 1.00 48.55 S O原子2971 OH2 TIP 145 2.573 17.750 14.486 1.00 47.73 S O原子2972 OH2 TIP 146 28.599 46.148 0.702 1.00 48.87 S O原子2973 OH2 TIP 147 22.071 23.744 5.544 1.00 41.02 S O原子2974 OH2 TIP 148 4.430 26.644-5.150 1.00 53.95 S O原子2975 OH2 TIP 149 31.991 42.944 16.456 1.00 36.38 S O原子2976 OH2 TIP 150 13.706 30.393 35.566 1.00 34.43 S O原子2977 OH2 TIP 151-8.927 24.840 28.174 1.00 49.19 S O原子2978 OH2 TIP 152 20.798 59.707 13.645 1.00 38.69 S O原子2979 OH2 TIP 153 1.401 45.680 29.309 1.00 37.43 S O原子2980 OH2 TIP 154 32.678 59.607-5.112 1.00 43.71 S O原子2981 OH2 TIP 155-6.700 39.184 2.850 1.00 68.13 S O原子2982 OH2 TIP 156 1.764 46.906 9.974 1.00 42.32 S O
原子2983 OH2 TIP 157 20.949 51.475-11.033 1.00 64.79 S O原子2984 OH2 TIP 158 9.913 43.769-12.840 1.00 53.16 S O原子2985 OH2 TIP 159 1.107 32.251 1.523 1.00 35.80 S O原子2986 OH2 TIP 160 24.448 50.273-12.912 1.00 43.68 S O原子2987 OH2 TIP 161-2.328 43.677 27.605 1.00 40.52 S O原子2988 OH2 TIP 162-12.391 33.882-5.094 1.00 59.21 S O原子2989 OH2 TIP 163 1.018 38.340 7.126 1.00 51.66 S O原子2990 OH2 TIP 164 28.227 19.148 15.962 1.00 51.92 S O原子2991 OH2 TIP 165-22.990 31.334-3.602 1.00 65.49 S O原子2992 OH2 TIP 166 32.281 29.119 23.671 1.00 43.47 S O原子2993 OH2 TIP 167-18.410 39.176 30.344 1.00 83.33 S O原子2994 OH2 TIP 168-28.321 37.642-1.802 1.00 50.58 S O原子2995 OH2 TIP 169 9.841 20.892 15.864 1.00 22.54 S O原子2996 OH2 TIP 170-11.075 13.785 23.440 1.00 57.17 S O原子2997 OH2 TIP 171-15.649 38.583 34.354 1.00 38.70 S O原子2998 OH2 TIP 172 23.891 37.353 38.826 1.00 40.19 S O原子2999 OH2 TIP 173-4.402 46.850 25.098 1.00 26.76 S O原子3000 OH2 TIP 174-7.879 41.469 30.407 1.00 44.51 S O原子3001 OH2 TIP 175 24.672 40.796 38.201 1.00 42.87 S O原子3002 OH2 TIP 176 0.323 49.278 10.809 1.00 44.27 S O原子3003 OH2 TIP 177-1.563 49.710 27.029 1.00 42.25 S O原子3004 OH2 TIP 178 30.467 28.497 9.731 1.00 70.19 S O原子3005 OH2 TIP 179 21.062 20.055 26.928 1.00 38.07 S O原子3006 OH2 TIP 180-10.108 41.945 6.596 1.00 63.83 S O原子3007 OH2 TIP 181 18.002 31.621 39.753 1.00 44.14 S O原子3008 OH2 TIP 182-5.867 26.073 35.63 1.00 56.58 S O原子3009 OH2 TIP 183-12.725 17.108 25.355 1.00 79.37 S O原子3010 OH2 TIP 184 26.533 51.508-9.941 1.00 56.56 S O
原子3011 OH2 TIP 185 1.968 52.801 23.026 1.00 102.86 S O原子3012 OH2 TIP 186 3.970 23.738-7.068 1.00 50.94 S O原子3013 OH2 TIP 187-20.685 36.643 13.221 1.00 34.27 S O原子3014 OH2 TIP 188 10.415 26.628 25.767 1.00 37.17 S O原子3015 OH2 TIP 189 32.397 37.704 37.161 1.00 53.37 S O结束由于已经例证并描述了本发明的优选实施方案，故而口可以在不背离本发明精神和范围的情况下做出各种变化。
序列表<110>希龙公司(Chiron Corporation)D.布西里(Bussiere，Dirksen)V.乐(Le，Vincent)<120>人GSK3的结晶方法及其新的晶体结构<130>CHIR-120512<150>US60/355,916<151>2002-02-11<160>2<170>PatentIn version 3.0<210>1<211>361<212>PRT<213>智人(Homo Sapiens)<400>1Met Glu Tyr Met Pro Met Glu Gly Gly Gly Gly Ser Lys Val Thr Thr1 5 10 15Val Val Ala Thr Pro Gly Gln Gly Pro Asp Arg Pro Gln Glu Val Ser20 25 30Tyr Thr Asp Thr Lys Val Ile Gly Asn Gly Ser Phe Gly Val Val Tyr35 40 45Gln Ala Lys Leu Cys Asp Ser Gly Glu Leu Val Ala Ile Lys Lys Val50 55 60Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu Leu Gln Ile Met Arg Lys65 70 75 80Leu Asp His Cys Asn Ile Val Arg Leu Arg Tyr Phe Phe Tyr Ser Ser85 90 95Gly Glu Lys Lys Asp Glu Val Tyr Leu Asn Leu Val Leu Asp Tyr Val100 105 110Pro Glu Thr Val Tyr Arg Val Ala Arg His Tyr Ser Arg Ala Lys Gln115 120 125Thr Leu Pro Val Ile Tyr Val Lys Leu Tyr Met Tyr Gln Leu Phe Arg
130 135 140Ser Leu Ala Tyr Ile His Ser Phe Gly Ile Cys His Arg Asp Ile Lys145 150 155 160Pro Gln Asn Leu Leu Leu Asp Pro Asp Thr Ala Val Leu Lys Leu Cys165 170 175Asp Phe Gly Ser Ala Lys Gln Leu Val Arg Gly Glu Pro Asn Val Ser180 185 190Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro Glu Leu Ile Phe Gly Ala195 200 205Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp Ser Ala Gly Cys Val Leu210 215 220Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe Pro Gly Asp Ser Gly Val225 230 235 240Asp Gln Leu Val Glu Ile Ile Lys Val Leu Gly Thr Pro Thr Arg Glu245 250 255Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr Glu Phe Lys Phe Pro Gln260 265 270Ile Lys Ala His Pro Trp Thr Lys Val Phe Arg Pro Arg Thr Pro Pro275 280 285Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr Thr Pro Thr Ala290 295 300Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe Phe Asp Glu Leu305 310 315 320Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp Thr Pro Ala Leu325 330 335Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro Pro Leu Ala Thr340 345 350Ile Leu Ile Pro Pro His Ala Arg Ile355 360<210>2<211>7<212>PRT<213>智人(Homo Sapiens)<220>
<221>-
<222>(6)..(6)<223>Xaa是磷酸丝氨酸<400>2Leu Ser Arg Arg Pro Xaa Tyr1 权利要求
1.一种结晶的GSK3-β复合物，其特征在于，该复合物包含(a)GSK3构建物；和(b)磷酸化多肽。
2.如权利要求1所述的复合物，其中所述构建物具有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
3.如权利要求1所述的复合物，其中磷酸化的多肽包括二磷酸化多肽。
4.一种晶体化的GSK3-β复合物，其特征在于，该复合物包含(a)具有表2所列原子坐标的GSK3-β构建物；和(b)磷酸化多肽。
5.如权利要求4所述的复合物，其中磷酸化多肽包括二磷酸化多肽。
6.一种结晶形式的多肽，其特征在于，该多肽包含GSK3的活性形式及其抑制物结合位点，其中该多肽含有表2所列的原子坐标。
7.如权利要求6所述的多肽，其还包含一种结合的配体。
8.一种提供GSK3蛋白质原子模型的方法，其特征在于，该方法包括(a)提供一种计算机可读的介质，其上储存有晶体形式GSK3蛋白质的原子坐标/X-射线衍射数据，该数据足以模拟GSK3蛋白的三维结构，其中晶体形式GSK3蛋白质包含GSK3构建物和磷酸化多肽；(b)分析获自(a)的原子坐标/X-射线衍射数据，提供可确定GSK3蛋白质原子模型的数据输出；和(c)获得可确定GSK3蛋白三维结构的原子模型输出数据。
9.一种计算机可读的介质，其上储存有权利要求8所述方法产生的GSK3蛋白质原子模型数据。
10.一种GSK3-β配体，其对应于权利要求8方法产生的配体模型的原子模型的物理模型。
11.一种设计能结合GSK3蛋白质的配体的方法，其特征在于，该方法包括利用表2所列的GSK3复合物的某些或所有的原子坐标。
12.一种设计能结合GSK3蛋白质的配体的方法，其特征在于，该方法包括(a)使纯化的GSK3蛋白结晶，以提供具有生物活性的晶体化GSK3蛋白，其中该晶体化GSK3蛋白质含GSK3构建物和磷酸化多肽；(b)用x-射线晶体学分辨该晶体化GSK3蛋白的结构，以获得适合于确定GSK3蛋白质三维结构的数据；(c)将分辨晶体化GSK3蛋白质结构所产生的数据应用于一种计算机算法，产生GSK3蛋白的模型，用于设计能结合GSK3蛋白活性位点的配体；和(d)运行重复的过程，因而可将分子结构应用于该计算机产生的模型，以鉴定GSK3结合配体。
13.如权利要求12所述的方法，其中晶体化的GSK3蛋白质含有表2所列的原子坐标。
14.如权利要求12所述的方法，其中GSK3蛋白质含SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
15.采用权利要求11-14中任一项方法设计的GSK结合配体。
16.一种通过测定潜在的介质和GSK3结合位点之间的结合性相互作用来鉴定GSK介质的方法，其特征在于，该结合位点由至少某些表2所列的原子坐标所确定，所述方法包括(a)在计算机屏幕上产生由此结合位点所确定的结合槽穴；(b)产生具有空间结构的化合物；和(c)确定该化合物是否能结合GSK3结合位点。
17.一种鉴定能介导GSK3活性的化合物的方法，其特征在于，该方法包括(a)设计GSK3的一种潜在介质，其将与基于表2所列的至少某些原子结构坐标的GSK3结合位点中的氨基酸形成非共价键；(b)获得此潜在的介体；和(c)确定此潜在的介体是否能介导GSK3活性。
18.一种鉴定能介导GSK3活性的化合物的方法，其特征在于该方法包括(a)利用表2所列原子坐标所确定的GSK3三维结构来设计或选择潜在的介质；(b)获得此潜在的介质；和(c)将此潜在的介质与GSK3接触，以确定该潜在的介质是否能介导GSK3活性。
19.一种用于产生分子或分子复合物三维图像或者产生该分子或分子复合物同源物三维图像的计算机，其中分子或分子复合物包含一个由表2所列GSK3的至少某些原子坐标所确定的结合槽穴，其中该计算机包括(a)一种机器可读数据存储介质，该介质包有由机器可读数据所编码的数据存储材料，其中所述数据含有表2所列的原子坐标；(b)内存储器，储藏用于处理机器可读数据的指令；(c)与内存储器和机器可读数据存储介质连接的中央处理器，用于将机器可读数据加工成为三维图像；和(d)与中央处理器连接的显示器，用于显示该三维图像。
20.一种用于确定对应于分子或分子复合物的X-射线衍射模式的至少一部分原子坐标的计算机，其特征在于，所述计算机包含(a)一种机器可读数据存储介质，其包含机器可读数据所编码的数据存储材料，其中所述数据包含表2所列的至少一部分原子坐标；(b)一种机器可读数据存储介质，其包含机器可读数据所编码的数据存储材料，其中所述数据包含该分子或分子复合物的X-射线衍射模式；(c)-内存储器，用于储藏处理(a)和(b)机器可读数据的指令；(d)与内存储器以及(a)和(b)的机器可读数据存储介质连接的中央处理器，用于执行(a)的机器可读数据的傅里叶转换，并且将(b)的机器可读数据加工成为结构坐标；和(e)与中央处理器连接的显示器，用于显示该分子和分子复合物的结构坐标。
21.一种使人糖原合成酶激酶3(GSK3)蛋白结晶的方法，其特征在于，该方法包括使纯化的GSK3蛋白结晶以获得具有生物活性的晶体化GSK3蛋白，其中晶体化的GSK3蛋白含有GSK3构建物和磷酸化肽，并且晶体化的GSK3蛋白可用x-射线晶体学分辨，以获得适合于晶体化GSK3蛋白的三维结构确定的x-射线图。
22.如权利要求21所述的方法，其中GSK3蛋白的结晶包括通过悬滴蒸汽扩散法进行结晶。
23.如权利要求21所述的方法，其中晶体化GSK3蛋白包含表2所列的原子坐标。
24.如权利要求21所述的方法，其中GSK3蛋白包含SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
25.如权利要求21所述的方法，其中磷酸化多肽包括二磷酸化多肽。
26.根据权利要求21所述的方法获得的晶体化GSK3蛋白质。
27.一种制造人糖原合成酶激酶3(GSK3)蛋白复合物的方法，其特征在于，该方法包括将可被磷酸化的多肽、腺苷三磷酸、镁盐、和GSK3蛋白相混合，获得含有磷酸化多肽、腺苷二磷酸和GSK3蛋白的GSK3蛋白复合物。
28.如权利要求27所述的方法，其中的蛋白含有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
29.如权利要求27所述的方法，其中可被磷酸化的多肽包括单磷酸化多肽。
30.一种制造人糖原合成酶激酶3(GSK3)蛋白复合物的方法，其特征在于，该方法包括混合磷酸化多肽和GSK3蛋白，获得GSK3蛋白复合物。
31.如权利要求30所述的方法，其中的蛋白质含有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
32.如权利要求30所述的方法，其中磷酸化多肽包括二磷酸化多肽。
33.一种制造人糖原合成酶激酶3(GSK3)蛋白晶体的方法，其特征在于，该方法包括在含有可被磷酸化的多肽、腺苷三磷酸、镁盐、和GSK3蛋白的溶液中加入一种沉淀剂。
34.如权利要求33所述的方法，其中的沉淀剂包括聚乙二醇。
35.如权利要求33所述的方法，其中的沉淀剂包括2-甲基-2，4-戊二醇。
36.如权利要求33所述的方法，其中的蛋白晶体包含表2所列的原子坐标。
37.如权利要求33所述的方法，其中的蛋白质含有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
38.如权利要求33所述的方法，其中磷酸化多肽包括单磷酸化多肽。
39.根据权利要求33所述的方法获得的晶体化GSK3蛋白质。
40.一种制造人糖原合成酶激酶3(GSK3)蛋白晶体的方法，其特征在于该方法包括在含有磷酸化多肽和GSK3蛋白的溶液中加入一种沉淀剂。
41.如权利要求40所述的方法，其中的沉淀剂包括聚乙二醇。
42.如权利要求40所述的方法，其中的沉淀剂包括2-甲基-2，4-戊二醇。
43.如权利要求40所述的方法，其中的蛋白质括有SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
44.如权利要求40所述的方法，其中磷酸化多肽包括二磷酸化多肽。
45.一种制造人糖原合成酶激酶3(GSK3)蛋白晶体的方法，其特征在于，该方法包括使晶体化的GSK3蛋白与潜在的GSK3介质接触，其中晶体化的GSK3蛋白包含GSK3构建物和磷酸化多肽。
46.如权利要求45所述的方法，其中GSK3蛋白包含SEQ ID NO1所示的氨基酸序列或其活性突变体或变型。
47.所述权利要求45所述的方法，其中磷酸化多肽包括二磷酸化多肽。
48.根据权利要求45所述的方法所获得的晶体化GSK3蛋白质。
全文摘要
本发明提供人糖原合成酶激酶3(GSK3)构建物的三维结构；含有蛋白质催化激酶结构域的人糖原合成酶激酶3－β(GSK3－β)构建物的晶体；使该蛋白质构建物结晶，以提供足以用于结构确定的GSK3晶体的方法；以及利用该GSK3构建物的三维结构来鉴定可能的治疗化合物，以治疗由GSK3活性所介导的各种疾病的方法。
文档编号C12Q1/48GK1630863SQ03803641
公开日2005年6月22日 申请日期2003年2月11日 优先权日2002年2月11日
发明者D·E·布西里, V·P·乐 申请人:希龙公司