泌素抑制剂DAPT，第四组在培养第39天时添加10μΜ的包覆F127高分子物质的 丁烯基苯酞。每组试验进行2~3次，并且以单因子变异数分析及多重比较测定分析数值 是否存在显数差异，其中，Ρ值小于0. 05,95%信心水准，记号*表示在0. 05的显著水准之 下，记号表示在0. 01的显著水准之下。
[0065] 由图8的结果可知，第一组的Αβ40浓度显著低于第二组的Αβ40浓度，而第三组 及第四组的Αβ40浓度分别较第二组下降。由此可知，本发明所揭丁烯基苯酞能显著降低 神经细胞内的Αβ40浓度，并且其效果类似于投予γ分泌素抑制剂DAPT。据此，本发明所 揭丁烯基苯酞确实具有改善或减缓细胞内累积过量β类淀粉样蛋白质的能力，而能达到 治疗或预防神经退化性疾病的功效。
[0066] 通过上述实施例的说明，本发明所揭医药组合物制备方法能以高分子物质作为药 物载体，减缓或降低丁烯基苯酞的细胞毒性，确实能有效提升医药组合物的安全性。而通过 上述方法所制得的医药组合物确实具有降低细胞内β类淀粉样蛋白质浓度的功能，因此， 通过投予有效量的医药组合物至生物体，能达到治疗或预防神经退化性疾病的功效。
[0067] 以上仅是通过各该实施例详细说明本发明，熟知该技术领域者在不脱离本发明精 神下，而对于说明书中的实施例所做的任何简单修改或是变化，均应为本案权利要求所涵 摄。
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