内源逆转录病毒构成传染性逆转录病毒的后代,其以它们的原病毒形式整合入种系细胞,并通过这种方式传染入宿主后代的基因组。
人类基因组测序使显示极高丰度的转座因子或其衍生物成为可能。实际上,重复序列代表接近一半的人类基因组,而内源逆转录病毒和逆转录转座子组成所述基因组的8%,当前元件数目接近超过400,000个。
目前存在于人类基因组的内源逆转录病毒元件(ervs)的丰度是约100代内生化(endogenizations)的结果,其成功地发生在人类品系的进化过程中。在我们的时代之前,内生化的不同波动跨越范围从200万年到9000万年的周期,并通过“拷贝/粘贴”型现象继之以拷贝数目的扩增,具有错误表型的可能性,起因于,源于hervs家族(即显示序列同源性的一组元件)形成中的遗传原病毒。根据推测最古老的元件(herv-l家族的那些元件)在哺乳动物出现之前已经整合。两个家族(herv-f和herv-h)在第一代灵长类动物塑造它们的外观时期已经出现。herv-frd和herv-k(hml-5)家族(在4000到5500万年前整合)是对高等灵长类动物特异的。另一方面,herv-w和herv-e家族,例如,在500万年到1000万年后整合,在与新大陆猴(newworldmonkeys)分离后,并且对狭鼻猴(似人猿的(hominoids)和猕猴科(cercopithecidae))是特异的。
erv序列在全部染色体上呈现,具有根据家族的不同密度,在ervs的物理邻近性与它们的种系发生邻近性之间不存在相关性。
很长一段时间内,ervs被认为是寄生物或是简单的dna废物。尽管如此,ervs对生物体的影响不是仅仅限于它们过去在模式化基因组中的参与或仍能提供支持的有害重组。
ervs的丰度和结构复杂性使它们的表达分析非常复杂,并且常常难于解释。herv表达的检测可以反映相同家族内一个或更多个基因座的转录活化。此外活化的单个基因座或多个基因座可能根据组织和/或背景而不同。
本发明人现在已经发现和证明,对应于精确鉴定的内源逆转录病毒元件的基因座的核酸序列与结肠癌有关,并且这些序列是病理性病症的分子标记物。鉴定的序列或者是原病毒,即序列包含位于长末端重复(ltrs)5'和3'位置侧翼的所有或部分gag、pol和env基因,或所有或部分的ltrs或所有或部分的分离的基因。鉴定的dna序列在序列表中分别用seqidno:1到285表示,它们的染色体位置在下文表中(ncbi36/hg18)标出,而它们的表达、过表达或低表达用癌症样本和正常样本之间的“表达比值”来表示。当核酸的表达或核酸表达的改变是对结肠组织特异时,该信息用靶组织列中的符号“x”来标示。这表示如果在除了结肠组织之外的生物区室中检测到相关核酸的表达或核酸表达的改变,这远程地代表结肠癌的标记物。经鉴定对结肠组织特异的dna序列在序列表中分别表示为seqidnos:1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97。经鉴定对结肠组织不特异的dna序列在序列表中分别表示为seqidnos:6,14,15,16,18,20,21,23,26,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284和285。
表
因此本发明的主题是一种用于取自患者的生物样本中结肠癌体外诊断或结肠癌严重性体外预后的方法,其包括检测至少一种核酸序列的至少一种表达产物的步骤,所述核酸序列选自seqidnos:1到285所示序列或选自与seqidnos:1到285所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
所述诊断使确定个体是否患病成为可能。所述预后使确定疾病的严重程度(分级和/或阶段)(其影响个体的生存和/或生活质量)成为可能。在本发明的背景下,诊断可以是非常早的。
通过考虑基因组的核苷酸多样性确定如上所述的百分比同一性。已经知道在富含重复序列的基因组区域中其核苷酸多样性要高于不包含重复序列的区域。举例来说,nickersond.a.等人(1)已经显示在包含重复序列的区域中大约0.3%(0.32%)的多样性。
通过使用sam方法(5)的统计学分析,继之以通过假阳性率的校正(6)和清除低于26的值,已经证明了区分上面所示每一序列的癌性状态的能力。因此,上面所示的每一序列在肿瘤状态和正常状态之间的表达显示显著差异。由此可知,观察到上述序列之一的表达差异构成病理性病症的标记物。当然,有可能将上文标示的几种序列的表达差异进行组合,例如通过所列序列中2,3,4,5,6,7,8,9,10种或甚至更高达285种的一种或更多种组合,优选的通过seqidnos∶1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97分别所示序列中2,3,4,5,6,7,8,9,10种或甚至更高达18种的一种或更多种组合。
具体来说,seqidnos:2,3和8所示序列,单独或组合(配对的或所有三个)构成一个或更多个优选的标记物。
因此,在本发明的方法中,检测至少两种核酸序列的相应的至少两种表达产物,所述核酸序列选自seqidnos:1到285所示序列或选自与seqidnos:1到285所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
在本发明方法的一个实施方案中,检测至少两种核酸序列的表达产物,所述至少两种核酸序列选自经鉴定对结肠组织特异的序列,即选自seqidnos∶1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示的序列组,或选自与seqidnos∶1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
在本发明方法的另一个实施方案中,检测选自经鉴定对结肠组织特异的序列的至少一种序列的表达产物,即选自如下所示的序列组:seqidnos:1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97,或选自与下列所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列:seqidnos:1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97,并检测至少一种序列的表达产物,所述序列选自经鉴定对结肠组织不特异的序列,即选自如下所示的序列组:seqidnos:6,14,15,16,18,20,21,23,26,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284和285,或选自与下列所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列:seqidnos:6,14,15,16,18,20,21,23,26,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284和285。
具体来说,在本发明的方法中,检测至少一种核酸序列的表达产物,优选的至少两种核酸序列或三种核酸序列的,所述核酸序列选自seqidnos:2,3和8所示的序列组,或选自与seqidnos:2,3和8所示序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
检测的表达产物是至少一种rna转录物,具体来说至少一种mrna或至少一种多肽。
当表达产物是mrna转录物时,可以通过任意合适的方法诸如杂交、测序或扩增对其进行检测。通过与至少一种探针和/或至少一种引物(其被设计以便在预定实验条件下与mrna转录物杂交)接触,显示与mrna杂交的存在或缺失并任选的定量mrna,可以对mrna进行直接检测。在优选的方法中,其可以由扩增(例如,rt-pcr,nasba等等)、芯片杂交或测序来构成。也可以使用来源于所述转录物的核酸(诸如cdna拷贝等等)来间接检测mrna。
通常,本发明的方法包括从待分析样本提取mrna的初始步骤。
因此,所述方法可以包括∶
(i)从待分析样本提取mrna的步骤,
(ii)从待分析样本检测和定量mrna的步骤,
(iii)从参照样本提取mrna的步骤,所述参照样本可以是源于相同个体的健康样本,或
(iv)从健康样本检测和定量mrna的步骤,
(v)将待分析样本和参照样本中表达的mrna量进行比较的步骤;有可能确定与健康参照样本表达的mrna量不同的待分析样本表达的mrna量与结肠癌严重性的诊断或预后有关(癌性结肠组织中mrna量相对于健康结肠组织中表达的mrna量的差异一般是表达、过表达或低表达);
和具体来说∶
(i)待分析样本中mrna的提取,
(ii)在待分析的rna中,测定样本中至少一种rna序列的表达水平,优选样本中至少两种rna序列的表达水平,所述rna序列和所述rna序列分别是至少一种核酸序列和至少两种核酸序列的转录产物,所述核酸序列选自seqidnos:1到285所示序列,或选自与seqidnos:1到285所示序列之一显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列,和
(iii)将(ii)确定的rna序列表达水平与参照表达水平进行比较;有可能确定相对于参照表达水平显示差异的待分析rna的表达水平与结肠癌的诊断或预后有关(如上所决定);或
(i)从待分析样本提取mrna的步骤,
(ii)从待分析样本检测和定量mrna的步骤,
(iii)对待分析样本中表达的mrna量相对于参照mrna量进行比较的步骤;有可能确定与参照mrna量不同的待分析样本表达的mrna量与结肠癌的诊断或预后有关(待分析样本mrna量相对于参照mrna量的差异一般是表达、过表达或低表达)。
在本发明方法的一个实施方案中,制备mrna的dna拷贝,在允许杂交的预定条件下将所述dna拷贝与至少一种探针和/或至少一种引物接触,并检测与所述dna拷贝杂交的存在或缺失。
被检测的表达产物也可以是多肽,其是如上所述至少一种转录物的翻译产物。在这种情况下,通过与所述多肽的至少一种特异性结合配偶体(具体来说是抗体或抗体类似物或适体)接触来检测表达的多肽。结合配偶体优选的是抗体,例如单克隆抗体或高度纯化的多克隆抗体或抗体类似物,例如具有竞争特性的亲和蛋白(nanofitintm)。
可以如下获得多克隆抗体:用合适的免疫原免疫动物,继之以回收纯化形式的所需抗体,通过抽取所述动物的血清,并将所述抗体与其他血清组分分离,具体来说通过柱(其上结合有被所述抗体特异性识别的抗原)的亲和层析。
可以通过杂交瘤技术获得单克隆抗体,其一般原理在下文概述。
首先,用合适的免疫原免疫动物(通常是小鼠),然后所述小鼠的b淋巴细胞能够产生针对该抗原的抗体。然后将这些抗体生成的淋巴细胞与“永生化的”骨髓瘤细胞(实施例中是小鼠)融合以产生杂交瘤。然后从如此获得的细胞异质混合物中挑选能够产生特定抗体并能无限增殖的细胞。每个杂交瘤以克隆的形式增殖,每种均导致单克隆抗体的产生,其中例如可以通过elisa,一维或二维western印迹,免疫荧光或使用生物传感器来检测针对蛋白的识别特性。随后将如此挑选的单克隆抗体纯化,具体来说根据如上所述的亲和层析技术。
单克隆抗体也可以是利用本领域技术人员公知的技术通过基因工程获得的重组抗体。
nanofitinstm是小蛋白,其像抗体一样能够结合生物靶标,从而使得在生物体内检测它、捕获它或非常简单的靶向它成为可能。它们尤其作为抗体类似物存在。
适体是能够结合特定配体的合成的寡核苷酸。
本发明还涉及已经分离的至少一种核酸序列作为结肠癌体外诊断或预后的分子标记物的用途,其特征在于所述核酸序列由以下组成:
(i)至少一种dna序列,其选自序列seqidnos:1到285,或
(ii)至少一种dna序列,其与选自序列seqidnos:1到285的序列互补,或
(iii)至少一种dna序列,其与(i)和(ii)限定的序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性,或
(iv)至少一种rna序列,其是选自(i)限定的序列的转录产物,或
(v)至少一种rna序列,其是下述序列的转录产物:选自与(i)限定的序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
在一个实施方案中,用途由至少两种核酸序列构成,所述核酸序列由以下组成∶
(i)选自序列seqidnos:1到285的至少两种dna序列,优选选自seqidnos:1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示序列,和具体来说是序列seqidnos:2,3和8,或
(ii)与至少两种序列分别互补的至少两种dna序列,所述至少两种序列选自序列seqidnos:1到285,优选选自seqidnos:1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示序列,和具体来说选自序列seqidnos:2,3和8,或
(iii)至少两种dna序列,其与(i)和(ii)限定的两种序列分别显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性,或
(iv)至少两种rna序列,其分别是选自(i)限定的两种序列的转录产物,或
(v)至少两种rna序列,其是下述两种序列的转录产物:选自与(i)限定的序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
本发明的主题还是一种用于取自患者的生物样本中结肠癌的体外诊断或预后的试剂盒,其包括至少一种核酸序列的至少一种表达产物的至少一种特异性结合配偶体,所述核酸序列选自seqidnos:1到285所示的序列或选自与seqidnos:1到285所示核酸序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列,并且包括不超过285种核酸序列表达产物的特异性结合配偶体,所述核酸序列如seqidnos:1到285所示,或所述核酸序列与seqidnos:1到285所示核酸序列之一显示至少99%同一性,优选的与seqidnos:1到285所示序列之一显示至少99.5%同一性和有利地至少99.6%或至少99.7%同一性。
在一个实施方案中,试剂盒包括至少两种核酸序列的至少两种表达产物的至少两种相应的特异性结合配偶体,所述核酸序列选自seqidnos:1到285所示的序列,或选自与seqidnos:1到285所示核酸序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列,并且包括不超过285种核酸序列表达产物的特异性结合配偶体,所述核酸序列如seqidnos:1到285所示,或所述核酸序列与seqidnos:1到285所示核酸序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性。
例如,所述试剂盒包括至少两种核酸序列的表达产物的至少两种相应的特异性结合配偶体,所述核酸序列选自seqidnos∶1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示的序列组,或选自与seqidnos∶1,2,3,4,5,7,8,9,10,11,12,13,17,19,22,24,25,27和97所示序列显示至少99%同一性的序列。
具体来说,所述试剂盒包括2种或3种核酸序列表达产物的相应的特异性结合配偶体,所述核酸序列如seqidnos:2,3和8所示,或与seqidnos:2,3和8所示序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性。
表达产物的最低特异性结合配偶体对应于上文给出的定义。
本发明还涉及一种鉴定结肠癌治疗效果和/或进展的方法,其包括:获得一系列生物样本的步骤,和在所述生物样本系列中检测至少一种核酸序列的至少一种表达产物的步骤,所述核酸序列选自seqidnos:1到285所示序列或选自与seqidnos:1到285所示序列显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
在一个实施方案中,检测至少两种核酸序列的至少两种表达产物,所述两种核酸序列选自seqidnos:1到285所示序列或选自与seqidnos:1到285所示序列分别显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
在所述方法的另一个实施方案中,检测至少一种核酸序列的表达产物,优选的至少两种核酸序列或三种核酸序列的,所述核酸序列选自seqidnos:2,3和8所示的序列组,或选自与seqidnos:2,3和8所示序列分别显示至少99%同一性,优选的至少99.5%同一性和有利地至少99.6%或至少99.7%同一性的序列。
术语“生物样本”旨在表示组织,体液,所述组织和体液的组分,诸如细胞或凋亡体,和分泌囊泡,具体来说包括外体和微泡。举例来说,生物样本可以来源于在怀疑患有结肠癌的患者中事先进行的结肠活检切片,或可以来源于在呈现转移瘤的患者中除了结肠之外的器官上进行的活检切片。就第二种情况来说,当核酸(分子标记物)的表达改变对结肠器官特异时,有可能回到原发癌,即结肠癌。生物样本也可以是生物体液,诸如血液或血液组分(血清,血浆),尿液,唾液,脑脊液,淋巴,母乳,精子,以及所述体液的组分,具体来说是如上所述的分泌囊泡。例如,在来源于上皮细胞的外体或微泡中检测到结肠组织特异性转录物,是原发癌或转移瘤存在的标记,无需在器官水平取样。
附图∶
图1和2显示结肠癌中对一组herv序列观察到的差异化表达。更具体地,图1(聚簇分析)以探索方式将herv元件分组,所述herv元件具有与所有对照组织相比与结肠癌有关的表达趋向性,而图2显示正常结肠和肿瘤性结肠之间herv元件表达的统计学差异。
图3和4显示两种生物体液∶尿液和血清中herv序列的检测。
图5显示针对28个结肠肿瘤和18个健康结肠组织,通过定量rt-pcr对序列seqidno:2,seqidno:3和seqidno:8获得的表达结果,具体来说证明了将它们组合的优势以便增加结肠直肠的肿瘤样本内的检出数量。
实施例∶
实施例1∶结肠癌中显示差异化表达的herv序列的鉴定
方法:
结肠癌中显示差异化表达的herv序列的鉴定是基于采用genechip形式的高密度dna芯片(称为herv-v2,由本发明人设计,其制造转包给affymetrix公司)的设计和使用。该芯片包含对应于人类基因组中独特的herv序列的探针。使用一组原型参照分割为功能区域(ltr,gag,pol和env),然后通过在整个人类基因组(ncbi36/hg18)范围的相似性检索,对这些序列进行鉴定,10035个不同herv基因座被鉴定、注释并最终集合在称为hervgdb3的数据库中。
基于hervgdb3确定作为芯片组成一部分的探针,并利用杂交特异性标准来挑选,其目的是从制备过程排除具有与不需要的靶标杂交的高风险的探针。为此,首先将hervgdb3序列分割成25个重叠核苷酸(25-mers)的组,从而产生候选探针组。然后使用kash算法(2),通过对整个人类基因组进行比对,评估每个候选探针的非特异性杂交的风险。实验评分记录杂交结果,添加比对中误差的数量、类型和位置的影响。该评分值与靶标/探针杂交能力有关。知晓候选探针在整个人类基因组范围的杂交能力使评估其捕获特异性成为可能。保留显示良好捕获亲和力的候选探针,然后将其集合为“探针组”,并最终在herv-v2芯片上合成。
使用herv-v2高密度芯片分析的样本对应于从肿瘤提取的rnas和从邻近于这些肿瘤的健康组织提取的rnas。分析的组织是结肠,利用乳腺,卵巢,子宫,前列腺,肺,睾丸和胎盘作为对照。就胎盘而言,只使用健康组织。对于每个样本,使用50ngrna用于利用称为wto的扩增方案的cdna合成。wto扩增的原理如下:在逆转录步骤之前添加随机引物,以及靶向rna转录物3'端的引物,继之以称为spia的线性、单链扩增。然后测定、表征并纯化cdnas,将2μg片段化,并通过末端转移酶的作用在3'端用生物素进行标记。将如此制备的靶标产物与对照寡核苷酸混合,然后按照affymetrix公司推荐的方案进行杂交。然后将芯片进行显影和读取以获得它们的荧光图像。进行基于标准对照的质量控制,使用一组指标(mad,mad-med图,rle)来排除不符合统计学分析的芯片。
芯片分析首先包括数据的预处理,通过使用基于色氨酸探针信号强度的背景噪声进行校正,继之以基于分位数方法的rma标准化(3)。然后通过使用combat方法(4)进行与实验批次有关的效果双校正,以便确保观察到的表达差异是生物学原因而非技术原因。在这个阶段,使用通过欧几里得分配(聚簇分析)集合数据的工具进行数据的探索性分析,并且最后,使用利用sam方法(5)的统计学分析,继之以通过假阳性率的校正(6)并清除低于26的值,以便寻找在组织的正常状态和肿瘤状态之间显示差异化表达的序列。
结果∶
对利用该方法通过分析herv-v2dna芯片产生的数据进行处理,使得能够鉴定出在正常结肠和肿瘤性结肠之间显示统计上显著的表达差异的一组“探针组”。此外聚簇分析的结果以及寻找对照样本之间的差异化表达显示herv元件的差异化表达是与肿瘤性结肠特异性相关的。
在肿瘤性结肠中显示差异化表达的herv元件的核苷酸序列如seqidnos:1到285所示,每种序列的染色体位置在ncbi参考36/hg18中给出;并且“靶组织”信息(x)标示了只在正常结肠和肿瘤性结肠(与对照组织之间的比较相比)之间的比较中观察到差异化表达的元件。还提供了作为正常状态和肿瘤状态之间表达比值的指示值,其只是为了显示而排列序列。
实施例2∶生物体液中herv序列的检测
原理∶
本发明人证明了在生物体液中检测到herv序列,这尤其使通过依赖原发性器官的远程检测来表征结肠癌成为可能。对来源于不同个体的20个尿液样本和38个血清样本进行研究。
在下列条件下对血清和尿液进行离心∶
血清∶4℃500g10分钟。回收上清液,再在4℃16500g离心20分钟。该第二次离心的上清液,不含细胞,但包含外体、微泡、核酸和蛋白,在芯片上进行分析。芯片是根据先前所述模式使用的herv-v2芯片。
尿液∶收集后在4℃800g离心4分钟。利用rna保护细胞试剂(rnaprotectcellreagenttm)回收沉淀物。然后,向沉淀物中添加裂解缓冲液之前,5000g离心5分钟。芯片是根据先前所述模式使用的herv-v2芯片。
结果∶
如图3和4所示,在血清上清液和来源于尿液的细胞沉淀物中均检测到大量阳性信号,包括对应于上文表中所列序列的表达信号。这证明了生物体液(具体来说是血清和尿液)是用于herv序列检测的有效的生物材料来源。通常可以接受的阳性阈值是约26,即64。
实施例3∶两种和三种herv序列的组合用于检测结肠直肠癌的优点验证
方法∶
提取来源于28个结肠肿瘤(ct1,ct2,ct3,ct65,ct94,cc1,cc2,cc3,cc4,cc5,cc6,cc7,cc8,cc9,cc10,549t,551t,553t,556t,558t,559t,560t,561t,601t,602t,604t,607t和615t)和18个健康结肠组织(cn1,cn2,cn3,cn64,cn93,549n,551n,553n,556n,558n,559n,560n,561n,601n,602n,604n,607n和615n)的rnas,将其用于证明两种或三种herv序列的表达结果的组合能够增加结肠直肠肿瘤样本内的检出数量。
对研究的所有46个样本进行对应于seqidno:2的区域1723-1824,seqidno:3的区域1540-1665和seqidno:8的区域1684-1923的定量rt-pcr扩增。利用deltact方法处理herv序列表达结果,并通过gapdh持家基因的表达结果进行标准化。结果显示于图5。
结果∶
seqidno:2的区域1723-1824的定量rt-pcr扩增对于11个结肠肿瘤样本(ct3,ct94,cc1,cc2,558t,559t,560t,561t,602t,604t和607t)是阳性的。对于健康的结肠组织样本没有观察到该区域的检出。
seqidno:3的区域1540-1665的定量rt-pcr扩增对于6个结肠肿瘤样本(ct1,ct3,ct94,cc5,cc8和cc10)是阳性的。对于健康的结肠组织样本没有观察到该区域的检出。
seqidno:8的区域1684-1923的定量rt-pcr扩增对于4个结肠肿瘤样本(ct3,cc2,cc6和cc10)是阳性的。对于健康的结肠组织样本没有观察到该区域的检出。
以累加的方式考虑,seqidno:2的区域1723-1824和seqidno:3的区域1540-1665的检测允许覆盖15个结肠肿瘤样本(ct1,ct3,ct94,cc1,cc2,cc5,cc8,cc10,558t,559t,560t,561t,602t,604t和607t),因此与单独考虑的上述herv序列的使用相比,显示两种herv序列的这种组合的灵敏度增加。
以累加的方式考虑,seqidno:2的区域1723-1824和seqidno:8的区域1684-1923的检测允许覆盖13个结肠肿瘤样本(ct3,ct94,cc1,cc2,cc6,cc10,558t,559t,560t,561t,602t,604t和607t),因此与单独考虑的上述herv序列的使用相比,显示两种herv序列的这种组合的灵敏度增加。
以累加的方式考虑,seqidno:3的区域1540-1665和seqidno:8的区域1684-1923的检测允许覆盖8个结肠肿瘤样本(ct1,ct3,ct93,cc2,cc5,cc6,cc8和cc10),因此与单独考虑的上述herv序列的使用相比,显示两种herv序列的这种组合的灵敏度增加。
最终,以累加方式考虑,seqidno:2的区域1723-1824和seqidno:3的区域1540-1665和seqidno:8的区域1684-1923的检测允许覆盖16个结肠肿瘤样本(ct1,ct3,ct94,cc1,cc2,cc5,cc6,cc8,cc10,558t,559t,560t,561t,602t,604和607t),因此与单独考虑或配对组合的上述herv序列的使用相比,显示三种herv序列的这种组合的灵敏度增加。
参考文献
1.nickerson,d.a.,taylor,s.l.,weiss,k.m.,clark,a.g.,hutchinson,r.g.,stengard,j.,salomaa,v.,vartiainen,e.,boerwinkle,e.andsing,c.f.(1998)dnasequencediversityina9.7-kbregionofthehumanlipoproteinlipasegene(人脂蛋白脂肪酶基因的9.7-kb区域的dna序列多样性).nat.genet.,19,233-240.
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序列表
<110>拜奥默里克斯公司
<120>用于结肠癌的体外诊断或预后的方法
<130>endocolpct
<150>fr1162049
<151>2011-12-20
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tttaaaaatcaagaaaaaaatctcatttacagtacaatagcacaaaaaataagattccta2520
agaataaacctaaccaagaaggtgaaaaatatctacaacaaaaactataaaacattgatg2580
aaaaatggaagaggacacaaataaatagaaggatacagaaaaatacccccatgttcattg2640
atttaaagaattggaattgttaaagtgtccatactacccaaaacaatctagagattcaat2700
gtaatagctatcaaaatatccatgatattcttcatagaaatagaaagaaaaatcctaaaa2760
tgtgtatggaaccacaaaagaccccaaatagccaaatcaatcttaagcaaacagaaccaa2820
gctagagggatcacatacctggcttcaaaatgtactacaaagctgtaataaccaaaatag2880
catggtagtggcataaaaacaggcatatacaccaagggactagaatacagttagaaataa2940
atccacagacttacaaccaactgattttcaacatagatgccaaaaatacacgttggggaa3000
agggcaatcacttcaataaatagtgtggaggaaactgagtatgtacatgcagacatggaa3060
ctagacccctatctctcaccatatgcaaaaattaactcaaaatggattaaaacttaaata3120
taatgtcaggtctctgagcccaagccaagccatcgcatcccctgtgacttgcatgtatac3180
gcccagatggcctgacgtaactgaagaatcacaaaagaagtgaaaaggtcctgccccgcc3240
ttaactgatgacattccaccattgtgatttgttcctgccccaccttaactgattaaccct3300
gtgaatcattctcctggctcagaagctccccaagtgagcaccttgtggccccagcccctg3360
cccaccagagaacaaccccctttgactgtaattttcctttacctacccaaatcctataaa3420
acagccccacccttaactccctttgctgactctcttttcggactcagcccacctgtaccc3480
aggtgaaataaacagccatgttgctcacacaaagcctgtttggtgatctcttcacacgga3540
cgcgcatgaaatttggagacatgactcggatcgggggacctcccttgggagatcaatacc3600
ctgtcctcttgttctttgctccatgagaaagatccaccaatgacctcaggtcctcagaac3660
aaccagcctgagaaacatctcaccaatttcaaatccggtaagcagcctctttttactctc3720
ttctccaacctccctcactatccctcaacctctttctcctttcaatcttggccccacatt3780
tctatctctcccttctcttaatttcaattcctttcaattcttttggtagagacaaaggag3840
acacgttttatccgtggacccaaaactctggcaccggtcacggactgggaaggcagcctt3900
cccttggtgtttaatcattgcagggacacctctctgattattcacccacgtttcaaaggt3960
gtcagaccatgcagggacacctgccttggtccttcacccttagcagcaagtcccattttt4020
ctggggcaggggcaagtacccctcaaccccttctccttcacccttagcagcaagtcccgc4080
tttcctggggcaggggcaagtacccctcaaccccttctccttcacccttagtggcaagtc4140
ccgctttcctagggggcaagaaccccccaatcacttatttccacaccccaacctcttatc4200
tctgcaccccaatcccttatttctgcaccctgacctcttatctctgtgccccaatccctt4260
atttccacgccccaacctcttatatctctgcaccccaatcccttatttctgcaccctgat4320
ctatctctgtgccccaaccccttttctggaaggtgagaacacctgaaccacttccctcca4380
tttctctactctctcttttctctaggtttgcttccttcactatgggcaaccttccaccct4440
ccattcctccttctactcccttggcctgtgttctcaaaaacttaaaacctcttcaactca4500
cacctgacctaaaacttaaacgccttattttcttctgcaatgctgcttgaccccaataca4560
aactcaacagtagttccaaatagccagaaaatggcactttgaatttttccatcctgcaaa4620
atctaaataattcttgtcgtaaaataggcaaacggtctgaggtgcctgacgtccaggcat4680
tcttttacacatcagtcccttcctagtctctgtgcccagtgcaactcgtcccaaatcttc4740
cttctttccctcccacctgtcccctcagtaccaaccccaagcgtcgctgagtctttctaa4800
tcttccttttctacagacccatctgacctctcccttcttccccaggctgctcctcgccag4860
gccgagctaggtcccaattcttcctcagcctctgctcctccaccctataatctttttacc4920
acctctcccctcctcacacctggtctggctcacagtttcattccatgactagccctcctc4980
cacctgcccagcaatttactcttaaaaaggtggctggagctaaaggcatagtcaaggtta5040
atgctcctttttctttatcccaaatcagaagtgtttaggctctgtttcatcaaatataaa5100
aatccagcccagttcatggctcatttggcagcaaccctgagacactttacagtcttagac5160
cctaaaaggtcaaaaggccgtcttattctcaaaatacattttattacccaatctgctcct5220
gacattaaataaaactccaaaaattaaattctggccctcaaaccccacaacaggatttaa5280
ttaacctcgccttcaaggtgtacaataatagaaaaaagttgcaattccttgcctccactg5340
tgagacaaaccccagccacatctccagcacacaagaacttccaaacgcctgaactgcagt5400
ggccacgcgttcctccagaacctcctcccataggagcttgcttcgtgtgccagaaatctg5460
gccactgggccaaggaatgcccgcagcccgggattcctcctaatccacgtcccatctctg5520
tgggaccccactgaaaatcggactgttcaactcacctggaagccactcccagagcccctg5580
gaacactggccaaaggctctctgactgactccttcccagatcttcttggcttagcagctg5640
aagactgacactgcccgatcacctcagaagcacccttgaccatcacggatgccgagctat5700
gggtaactctcacagtggaaggtaagcccgtccccttcttaatcaatacggaggctaccc5760
acgccacattaccttcttttcaagggcctgtttcccttgcctccataactgttgtgggta5820
ttgacggccaggcttctaaacctcttaaaactccccaactctggtgccaacttagacaat5880
actcttttaagcactcctttttagttatccccatctgcccagttcccttattaggctgag5940
acactttaactaaattatctgcttccctgactattcctggactacagctgtatctcattg6000
ccacccttcttcccaatccaaagcctcctttgtgtcctcctcttgtatacccccacctta6060
acccacaagtataagatatctctactccctccttgacgaccgatcatgcaccccttacca6120
tctcattaaaacctaatcacccttaccgcactcaatgccagtatcccattccgcagcacg6180
ctttaaaaagattaaagcctgttatcattcgcctgttacagcatggccttttaaacccta6240
taaactctccttacaattcccccatttttcctgtcctaaaacgagacaagccttacaagt6300
tagttcaggatctgcaccttatcaaccaaattgttttgcctatccaccccgtggtgccaa6360
acccatatactctcctatcctcaatacctccctctactacccattattctgttctggatc6420
tcagacatgctttctttactattgctttgcacccttcatcccagcctctctttgccttca6480
cttagactgaccctgacacccattaggctcaacaaattacctgggctgcactgccacaag6540
gcttcacagacagcccccattacttcagtgaagcccaaatttcatcctcatctgttagtc6600
atactcctgttcaccgttctcaactactcatacatgccctgctcttctttacactgccgg6660
tttacactgtttctccaagacatcacagctgatatctcctggtgctatccccaaactgcc6720
actctaaactcttgaagtaaataaataatctttgctggcaggactctgctgaatctcctt6780
aggcactctctaatcagatatcctaggtcctcccaattcttagaccttttatacctgttt6840
ttctccttctgttattccatttagtttctcaattcatacaaaaccgtatccaggccatca6900
ccaatcattctatatgacaaatgtttcttcttacatccccacaatatcaccctttaccac6960
aagacctcccttcagcttaatctctcccactctagattcccacgctgcccctaatcccac7020
ttgaagcagccctgagaaacatcgcccattctctctccctaccacccctcaaaaattttc7080
accaccccaacacttcaacactattttgttttatttttcttattaatataagaaggcagg7140
aatgtcaggcctctgagcccaagccaagccatcgcattccctgtgacttgcacgtatacg7200
cccagatggcctgaagtaactgaagaatcacaaaagaagtgaaaaggtcctgccccacct7260
taactgatgatattccaccattgtgatttgttcctgccccaccttaactgagtgattaac7320
cctgtgaattgttctcctggctcagaagctccccaactgagcaccttgtgacccccaccc7380
ctgcccaccagagaacaacccccttttactgtaattttcctttaccaacccaaatcctat7440
aaaatggccccacccctatctcccttcgctgactctctttttggactcagcccgcctgca7500
cccaggtgaaataaacagccatgttgctcaaacaaagcctgtttggtggtctcttcacac7560
ggatgtgcatgaaa7574
<210>2
<211>5846
<212>dna
<213>智人
<400>2
gtcaggcctctgagcccaagccaagccatcgcatcccctgtgacttgcatgtatacgccc60
agatggcctgaagtaactgaagaatcacaaaagaagtgaatatgccctgccccaccttaa120
ctgatgacattccaccattgtgatttgttcctgccccaccctaactgatcaatgtacttt180
gtaatctcccccacccttaagaaggtcctttgtaattctccccacccttgagaatgtact240
ttgtgagatccacccctgcccaccagagaacaaccccctttgactgtaattttccattac300
cttcccaaatcctataaaacggccccacccctatctccctttgctgactctcttttcgga360
ctcagcccgcctgcacccaggtgaaataaacagccatgttgctcacacaaagcctgtttg420
gtggtctcttcacatggacgcacatgaaatttggtgccatgactcggatcgggggacctc480
ccttgggagatcaatcctccgtcctcctgctctttgctccctgagaaagatccacctacg540
acctcaggtcctcagaccgacgagcccaagaaacatctcaccaatttcaaatctggtaag600
cagcctctttttactctcttctccaacttccctcactatccctcaaccactttctccttt660
caatcttggcactacacttcaatctctcccttctcttaatttcaattcctttcattttct720
ggtagagacaaaagagacacgttttatccgtggacccaaaactccggcgctggtcacaga780
ctgggaaggcagccttcccttggtgtttaatcattgcagggatgcctctctgattataca840
cccacgtttcaagggtgtcagaccacgcagggacaactgccttggtccttcacccttagc900
agcaagtcccgcttttctggggaaggggcaagtaccccaaccccttctctccgtgtctct960
accccttctctgcttttccggggacagggcaagtaccccaaccccttctctccgtgtctc1020
tactccttctctgcttttctggggacagggcaagtaccccaaccccttctctccttgtct1080
ctaccccttctctgcttttctggggcaggggcaagtacccctcaaccccttctccttcac1140
ccttagcggtaagtcccgcttttctagggggcaggggcaagtaccccccaaccccttctc1200
cttcacccttagtggcaagtcctgctttcctggggcaggggcaagtaccccttaacccct1260
tctccttcacccttagcagcaagtcccacttttctagggggcaagaaaccccaaacccct1320
tccctccgtgtctttacgctctcttttctctgggtttgcttccttcactatgggcaacct1380
tccatcctccattcctccttctcccttagcctgtgtgctcaagaacttaaaacctcttca1440
actcacacctgacctaaaacctaaatgcctcattttcttctgcaacaccgcttggcccca1500
atacaaacttgacaatggctctaaatggccagaaaatggcactttcgatttctccatcct1560
acaagacctaaataatttttgtcaaaaaatgggcaaatggtctgaggtgcctgatgtcca1620
ggcattcttttacacatccgtcccttcctagtctctgtgcccagtgcaactcgtcccaaa1680
tcttccttctttccctcccacctgtcccctcagtcccaaccccaggcgttgctgagtgtg1740
tctaatcttccttttctacaaacccatctgacctctcccctcctctccacgccaagctag1800
gtcccaattcttcctcaggctccactcctccaccctgtaatctttttatcacctcccctc1860
ctcacacctggtccggcttacagtttcgttccgtgactagccctcccccacctgcccagc1920
aatttactcttaaaaaggtggctggagctaaagacatagtcaaggttaatgctccttttt1980
ctttatcccaaatcagaagcgtttaggctctttttcatcaaatataaaaacccagcccag2040
ttcatggctcgttcggcagcaaccctgagacgctttacagccctagaccctaaaaggtca2100
aaaggccgtcttattctcaatatacattttattacccaatctgctcccgatattaaataa2160
aactccaaaaattaaattccggccctcaaactccacaacaggatttaattaacctcgcct2220
tcaaggtgtacaataataaaaaaaaaaaagttgcaattccttgcctccactgtgagacaa2280
accccagccacatctccagcaaacaagaacttccaaacacctgaaccgcagcagccaggc2340
gttcctccagaacctcctcccacaggagcttgctacaagtgccagaaatctggccaccaa2400
gccaagaaatgcctgcagcccaggattcctcctaagccgtgtcccatctgtgcgggaccc2460
cattggaaatcagactgttcaactcacctggcagcgactcccagagaccctggaactctg2520
gcccaaggctctctgactgactccttcccagatcttctcggcttagcggctgaagactga2580
cgctgcccaatcacctcggaagccctgtagaccatcacagacactgagctttaggtaact2640
ctcacagtggagggtaagtccgtccccttcttaatcaatatggaggctccccactccaca2700
ttacctacttttcaagggcctgtttcccttgcctccataactgctgtgggtattgacggc2760
caggcttctaaacctcttaaaacttcccaactctagtgccaacttagacaatactctttt2820
acgcactcctttttagttatccccacctgcccagttcccttattaggccgagacacttta2880
actaaattatctgcttccctgactactcctggactacagctgcatctcattgccgccctt2940
attcctaatccaaagcctcctttgcgtcctcctcttgtatccccccaccttaacccacaa3000
gtataagatacctctactccctccttggcgaccgatcatgcaccccttaccatctcatta3060
aaacctaatcacccttaccccgctcaacaccaatatcccatcccacagcatgctttaaaa3120
ggattaaagcctgttatcacttgcctgctacagcatgggctcctaaaacctataaactct3180
ccttaccattcccccattttacctgtcctaaaaccagacaagccttacaagttagttcag3240
aatctgcgccttatcaaccaaatgttttgcctatccaccccgtggtgccaaacccgtata3300
ctcttctatcctcaatacctccctctactacccattattctgttctggatctcaaacatg3360
ctttctttactattcctttgcacccttcatcccagcctctctttgccttcacttagactg3420
accctgacacccattaggctcagcaaattacctgggctgtactgccgcaaggcttcacag3480
acagcccccattacttcagtcaagcccaaatttcatcctcatctgttacctatctcagca3540
taattctcataaaaacacaggtgctctccctgctgatcgtgtccgattaatctcccaaac3600
ctcaatcccttacaaaagaacaactcctttccttcctaggcatggttagtgtggtcagaa3660
ttcttacacaagagccaggactgcaccctgtagcctttctgtccaaacaacttgaccttc3720
ctgttttagcctagccatcatgtctgtgtgcagccgctgccgctgctttaatactgttag3780
aggccctcaaaatcacaaactatgctcaactcactctctacatttctcataacttccaaa3840
atctattttcttcctcatacctgacgcatatactttctgctccccggctccttcagctgt3900
actcacactttcttaagtcccacaattaccattgttcctggcctggacttcaatctggcc3960
tcccacattattcctgataccacacctgacctccatgactgtatctctctgatccacctg4020
atattcaccccatatttccttctttcctgttcctcaccctgatcacgcttgatttattga4080
tggaagttccaccaggcctaatcgccacacaccagcaaaggcaggttatgctatagtaca4140
agccactagcccacctctcagaacctctcatttcctttccatcgtggaaatctatcctca4200
aggaaataacttctcagtgttccatctgctattctactactcctcagggattattcaggc4260
cccctcccttccctacacatcaggctggaggatttgccccacccaggactggcaaattac4320
ctttactcaacatgccctgattcaggaaactaaaatacctcttagtctaaatagacactt4380
tcactgaataaagtaaaggcctttcctacagggtctgagaaggccaccacagtcatttct4440
tcccttctgtcagacacaattcctcagtttagccttcccacctctatacagtctgataac4500
agaccagcctttattagtcaaatcagccaagcagtttttcaggctcttagtattcagtga4560
aacctttatatcccttacggtcctccttcttcaagaaaagtagaacggactaaaggtctt4620
ttaaaaacacacctcaccaagctcagccaccagcttaaaaaggactggacaatactttta4680
ccactttcccttctcagaaatcaggcctgtcctcagaatgctacaaggtacatcccattt4740
aagctcctgtatagacgctcctttttattaggccccagtctcattccagacaccagacca4800
acttagactgtgccccaaaaaacttgtcatccctactatcttctgtctagtcatactcct4860
attcaccgttctcaactactcatacatgccctgctcttgtttacactgccggtttacact4920
gtttctccaagccatcacagctgatatctcctggtgctatccccaaactgccactcttaa4980
ctcttgaagtaaataatctttgctggcaggactatgctgaatctccttaggcactctcta5040
atcagatgtcctaggtcctcccaattcttagacatttaatacccatttttctcctccttt5100
tattcggaccttgtatcttccatttagcttctcaaatcatccaaaaccgtatccaggcca5160
tcaccaatcattctatacgacaaatgtttcttctaacatccccatgatatcaccccttac5220
cacaagacctcccttcagcttaatctctcccactctaggctcccacgccgcccctaatcc5280
cgcttgaagcagccctgagaaacatcgcccattatctctccataccaccccccaaaaatt5340
ttcgctgccccaacacttcaacactattttgttttatttgtcttattaatataagaaggc5400
aggaatgtcaggcctctgagcccaggccaggccatcgcatcccctgtgacttgcacgtat5460
acatccagatggcctaaagtaactgaagatccacaaaagaagtaaaaacagccttaactg5520
atgacattccaacattgtgatttgttcctgccccaccctaactgataaatgtactttgta5580
atctcccccacccttaagaaggtcctttgtaattctccccacccttgagagtgtactttg5640
tgagatccacacctgcccaccagagaacaaaccccctttgactgtaattttccattacct5700
tccctaatcctataaaacggccccaccccatctccctttgctgactctcttttcggactc5760
agcccgcctgcacccaggtgaaataaacagccttgttgctcacacaaagcctgtttggtg5820
gtctcttcacacggacgcgcgtgaaa5846
<210>3
<211>4729
<212>dna
<213>智人
<400>3
gtcaggcctctgagcccaagccaagccatcgcatcccctgtgacttgcacgtatacatcc60
agatggtctgaagtaactgaagatccacaaaagaagtaaacatagccttaactgatgaca120
ttccaccattgtgatttgttcccgccccaccctaactaatcaatgtactttgtaatctcc180
cccacccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagat240
ccacccctgcccacaaaacattgctcttaacttcaccgcctatctcaaaacctataagaa300
ctaataataatccaccactctttgctgactctctgtttggactcagcccacctgcaccca360
ggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacacggac420
gcgcatgaaatttggtgtcgtgactcagattgggggacctcccttgggagatcaatcccc480
tgtcctcctgctctttgctctgtgagaaagatccacctacgacctcaggaccgaccagcc540
caagaaacatctcaccaatttcaaatccagtaagcggcctctttttactctcttctccaa600
cttgcctcactatccctcaacctctttctcctttcaatcttggcgctacacttcaatctc660
tcccttctcttaatttcaattcctttcattttctggtagagacaaaagagacacgtttta720
tccgtggacccaaaactccggcgccggtcacggactgggaaggcagccttcccttggtgt780
ttaatcattgcagggatgcctctgtgattatacacccacgtttcaagggtgtcagaccac840
gcagggacgcctgccttggtccttcacccttagcggcaagtcctgcttttctggggaagg900
ggcaagtaccccaaccccttctctccttgtctctaccccttctctgcctttcctggggca960
ggggcaagtacccctcaaccccttctccttcacccttagcggcaagtcccgctttcctag1020
gggcaagaacctcccaatcgcttatttccgcaccccaacctcttatctctgtgccccaat1080
cccttatttccgtgccccaaccctttctctgcttttctggagggcaagaactccccaccc1140
cttctccatgtctctactcttttctctgggcttgcctccttcactatgggtaggcttcca1200
ccttccattcctccttgttctcccttagcctgtgttctcaaaaacttaaaacctcttcaa1260
ctcacacctgacctaaaacctaaatgccttattttcttctgcaatgccgcttgaccccaa1320
tacaaactcgacagtagttccaaatagctggaaaacggcgctttcaatttttccatccta1380
caagatctaaataattcttgtcgtaaaatgggcaaatggtctgaggtgcctgacgtccag1440
gcattcttttacacatcagtcccttcctagtctctgtgccccgtgcaactcgtcccaaat1500
cttccttctttccctccctcctgtcccctcagtcccaaccccaagcggcgctgagtcttt1560
ctaatcttcctcttctacagacccatctgacctctcccctccgcgccagcccaagctagg1620
tcccaattcttcctcagcctccgcgcctcccctcccttcatcccacacctggtccgactt1680
atagtttcattctgtgactagccctcccccacctgcccagcagtttactcttaaaaaggt1740
ggctggagccaaaggcatagtcagggttaatgctcctttttcattatcccaaatcacata1800
gcgtttaggctctttttcatcaaatataaaaacccagcccagttcatggctcgttcggca1860
gcaaccctgagacgctttacagccctagaccctaaaaggtcaaaaggccatcttattctc1920
aatatacattttattacccgatctgctcccgacattaaataaaactccaaaaattaaatt1980
ccggccctcaaaccccacaacaggatttaattaacctcgccttcaaggtgtacaataata2040
gaaaaaagttgcaattccttggctccactgtgagacaaaccccagccacatctccagcat2100
acaagaacttccaaatgcctgaaccgcagcggccaggcgttcttctagaacctcctcccc2160
caggagcttgctacaagtgccagaaatctgaccaccagggcaaggaatgcctgcagccca2220
ggattcctcctaagccgtgtcccatctgtgcgggaccccactggaaattagactgttcaa2280
ctcacctggcagccactccccgagcccctggaactctggcccgaggctctctgactgact2340
ccttctcggcttagcggctgaagactgatgctgcccgatcgcctcggaagccccgtaggc2400
catcacggacgccgagctttgggtaactctcagagtggaaggtaagtccgtccccttctt2460
aatcaatatggaggctacccactccacattaccttcttttcaagggcctgtttcccttgc2520
ctccataactgttgtgggtattgacagccaggcttctaaacctcttaaaactccccaact2580
ctggtgccaacttagacaacactcttttaagcactcttttttagttatctccacctgccc2640
acttcccttattaggccgagatattttaaccaaattatctgcttccctgactattcctgg2700
actacagccgcatctcattgctgcccttcttcccaatccaaagcctcctttgcgtcctcc2760
tcttgtattcccccaccttaacccacaagtataagagacctctactccctccttggtgac2820
tgatcacgcaccccttaccatctcattaaaactgaatcacccttaccccgctcaacgcca2880
atatcctatcccacagcatgctttaaaaggattaaagcctgttatcactcgcctgctaca2940
gcatgggcacctataaactctccttaccattcccccatttcacctgtcctaaaaccaggc3000
aaggcttacaagttagttcagaatctgcaccttatcaaccaaattgttttgcctatccac3060
cctgtggtgccaaacccatatactctcctatcctcaatacctccctctactacccattat3120
tctgttctggatctcaaacatgctttctttactattcctttgcacccttcatcccagcct3180
ctctttgccttcacttagactgaccctgacacccattaggctcagtaaattacctgggct3240
gtactgccgcaaggcttcgcggacagcccccattacttcagtcaagcccaaatttcatcc3300
tcatctgttacctatctcggcataattctcatagaaacacatgtgctcttcctgctgatc3360
atgtccgattaatctcccaaacctcaatcccttacaaaagaacaactcctttccttccta3420
ggcatggttagtgcggtcagaattcttacacaagagccaggaccacaccgtgtagccttt3480
ctgtccaaacaacttgaccttactgttttagcctagccctcatgtctgcgtgcagcggct3540
gccgctgctttaataccgttagaggccctaaaaatcacaaactatgctcaactcactctc3600
tacatttctcataacttccaaaatctattttcttcctcatacctgacacatatactttct3660
gctccccggctccttcagctgtactcactctttaagtcccacaattaccattgttcctgg3720
cccggacttcaatctggcctcccacattattcctgataccacacctgacccccatgactg3780
tatctctctgatccacctgatattcaccccatttccccatatttccttctttgctgttcc3840
tcaccctgatcacgcttgcctcgtgctatccccaaactgccattcttaactcttgaagta3900
aataatctttgctggcagggctatgctgaatctccttaggcactctctaatcagatgtcc3960
tgagtcgtcccaattcttagaccttttatacctgtttttctccttctcttattccattta4020
gtttttcaattcatacaaaaccatatccaggccatcaccaataattctacacaacaaatg4080
tttcttctaacaaccccacaatatcaccccttaccacaaaatcttccttcagcttaatct4140
ctcccactctaggttcccacgccacccctaatcccgctcgaagcagccctgagaaacatc4200
gcccattctctctccacaccaacccccacaaattttcaccgccccaagacttcaacacta4260
ttttgttttatttttcttattaatataagaaggcaggaatgtcaggcctctgagcccaag4320
ccaagccatcgcatcccctgtgacttgcacgtatacatccacgtggcctgaagtaactga4380
agatccacaaaagaagtaaacatagccttaactgatgacattccaccattgtgatttgtt4440
cccgccccaccctaactaatcaatgtactttgtaatctcccccacccttaagaaggttct4500
ttgtaattctccccacccttgagaatgtactttgtgagatccaccccgcccacaaaacat4560
tgctcttaacttcactgcctaacccaaaacctataagaactaataataatccaccactct4620
ttgctgactctctttttggactcagcccacctgcacccaggtgaaataaacagccatgtt4680
gctcacacaaagcctgtttggtggtctcttcacacagacgcgcatgaaa4729
<210>4
<211>4609
<212>dna
<213>智人
<400>4
gtcaggcctctgagcccaagccaacccatcgcatcccctgtgacttgcacgtatacgccc60
agatggcctgaagtaactgaagaatcacaaaagaagtgaaaaggccctgccccgccttaa120
ctgatgacattccaccattgtgatttgttcctgccccaccttaactgagtgattaaccct180
gcaaatttccttctcctggctcagaagctcccccactgagcaccctgtgacccccacccc240
tgcccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatcctata300
aaacggccccacccctatctccctttgctgactctctttttggactcagcccgcctgcac360
ccaggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacaca420
gatgcgcaagaaatttggtgccgtgactcggatcaggggacctcccctgggagatcaatc480
ccccgtcctcctgctctttactccatgagaaagacccacctacgacctcaggtcctcaga540
ccaaccagcccaagaaacatctcaccaatttcaaatccggtaagcggcctctttttactc600
tcttctccaacctccctcactatccctcaacctctttctcctttcaatcttggcgccaca660
cttcaatctctcccttctcttaatttcaattcctttcattttctggtagagacaaaggag720
acatgttttatccgtgtacccaaaactccggcgccagtcacggactgggaaggcagcctt780
cccttggtgtttaatcattgcagggacgcctctctgattatacacccacgtttcaagggt840
gtcagaccacgcagggacacctgctttggtccttcacccttagcggcaagtcccgctttt900
ctggggaaggagcaagtaccccaaccccttctctccttgtctctaccccttctctgcttt960
tccagggacagggcaagtaccccaaccccttctctccttgtctctaccccttctctgctt1020
ttccggggagagggcaagtaccccaaccccttctctccttgtctctaccccttctctgct1080
tttccagggacagggcaagtaccccaaccccttctctccttgtctctaccccttctctgc1140
ttttctgggagaggggaaagtacccctcaaccccttctccttcacccttagcggcaagtc1200
ccgctctcctagggggcaagaaccccccaatcgcttatttccatgccccaacctctgatc1260
tctgcgccccaatcacttatttccatgccccaacctcttatgtctgtgccccaatccctt1320
ttttccacaccccaacctcttatttctgtaccccaatcccttatttccatgccccaaccc1380
tttctctgcttttctggagggcaagaaccccccaccccttctccgtgtctctactctttt1440
ctctgggcttgcctcctttactatgggcaagcttccaccttccattcctccttcttctcc1500
cttagcctgtattcttaagaacttaaaacctcttcaattctcacctgacctaaaatctaa1560
gcgtctcattttcttctgcaatgccgcttgaccccaatacaaactcgacagtagttccaa1620
atagccagaaaacggcactttcaatttttccatcctacaagatctaaataattcttgtcg1680
taaaatgggcaaatggtctgaggtgcctgacgtccaggcattcttttacacatcagtccc1740
ttcctagtctctgtggccagtgcaactcgtcccaaatcttccttctttccctcccgcctg1800
tcccctcagtaccaaccccaagcgtcgctgagtctttctaatcttccttttctacagacc1860
catctgacctctcccttcctccccaggctgctcctcgccaggccgagctaggtcccaatt1920
cttcctcagcctccgctcctccaccctataatccttttatcacctcccctcctcacacct1980
gctccggcttacagtttcgttccgtgactagccctccccctcctgcccagcaatttactc2040
ttaaaaaggtggctggagccaaaggcatagtcagggttaatgctcctttttctttatccc2100
aaatcagatagtgtttaggctttttcatcaaatataaaaacccagcccagttcatggctc2160
attcggcagcaaccctgagacgctttacagctctagaccctaaaaggtcaaaaggccgtc2220
ttatgctcaatatacattttattacccaatctgccccggacattaaataaaactccaaaa2280
attaaatccggccctcaaaccccacaacaggacttaattgacctcaccttcaaggtgtag2340
aataataaaaaaaaaaagttgcaattccttgcctccgctgtgagacaaaccccagccaca2400
tctccagcacacaagaacttccaaatgcctgaaccacagcagccaggcgttcctccagaa2460
cctcctcccacaggagcttgctacatgtgccggaaatctggccactaggccaaggaatgc2520
ctgcagccccggattcctcctaagccgtgtcccatctgtgcgggaccccactgaaaatcg2580
gactgttcaactcacctggcagccactctcagagaccctggaactctggcccaaggctct2640
ctgactccttcccagatcttcttggcttagcggctgaagactgacactgcccgatcgcct2700
cggaagccccctagaccatcatggacgccgagcttcgggtaactctcacagtggaaggta2760
agcccgtccccttcttaatcaatacggaggctacccactccacattaccttcttttcaag2820
ggcctgtttcccttgcctccataactgttgtgggtattaacagccaggcttctaaacctc2880
ttaaaactccccaactctggtgccaacttagacaatactcttttaagcactcctttttcg2940
ttatccccacctgcccagttcccttattaggctgagacactttaactaagttatctgctt3000
ccctgactattcctggactacagccacatctcattgccgcccttctccccaacccaaagc3060
ctccttcgcgtcttcctctcatatccccccaccttaacccgcaagtatgggacatctcta3120
ctccttccctggcaaccgatcacatgccccttaccatcccattaaaacctaatcaccctt3180
accccgctcaacgccaatatcccatcccacagcacgctttaaaaagattaaaacctgtta3240
tcactcgcctgctacagcgtggccttttaaagcttataaactctccttaccattccccca3300
ttttacctgtcctaaaaccagacaagccttacaagttagttcagaatctgcgccttatca3360
accaaattgttttgcctatccaccccgtggtgccaaacccatagactctcctatcctcaa3420
tacctccctctactacccattattctgttctggatctcaaacatgctttctttactattc3480
cttgcacccttcatcccagcctctctttgccttcacttagactgaccctgacacccatta3540
ggctcagcaaattacctgggctgtactgctgcaaggcttcacagacagcccccattactt3600
cagtcaagcccaaatttcatcctcatctgttagtcatactcctattcactgttctcaact3660
actcacacatgccctgctcttgtttacactgccggtttacactctttctccaagacatca3720
caggtgatatctcctagtgctatccccaaactgccactctaaactcttgaagtaaataaa3780
taatctttgccggcaggactatgctgaatctccttaggcactctctaattagatggccta3840
ggtcctcccaattcttagtccttttatacctgtttttcgccttctcatattccatttagt3900
ttttcaattcatacaaaaccgtatccaggccatcaccaatcattctatatgacaaatgtt3960
tcttcttacatccccacaatatcaccccttaccacaagacctcccttcagcttaatctct4020
cccactctaggttcccacgccgcccctaatcccacttgaagcagctctgagaaacatcac4080
ccattctctctccataacacccccaaaaatttttgccgcctcaacacttcaacactattt4140
tgttttatttttcttattaatataagaaggcaggaatgtcaggcctctgagcccaagcca4200
agccatcgcatcccctgtgacttgcacgtatacgcccagatggcctgaagtaactgaaga4260
atcacaaaagaagtgaaaaggccctgccccgccttaactgatgacattccactattgtga4320
tttgttcctgccccaccttaactgagtgattaaccctgcgaatttccttctcctggctca4380
gaagctcccccactgagcaccttgtgaccccccacccctgcccaccagagaacaaccccc4440
tttgactaattttccattaccttcccaaatcctataaaacggccccacccctatctccct4500
tcgctgactctcttttcggactcagcccacctgcacccaggtgaaataaacagccatgtt4560
gctcacacggagcctgtttggtggtctcttcacacagacgcgcatgaaa4609
<210>5
<211>6026
<212>dna
<213>智人
<400>5
gtcaggcctctgagcccaagccaagccatcgcatcccctgtgacttgcacgtatacgccc60
agatggcctgaagtaactgaagaatcacaaaagaactgaaaaggccctgccccgccttaa120
ctgatgacattccaccatggtgatttgttcttgccccaccttaactgagtgattaaccct180
gtgaatttccttctcctggctcagcagctcccccactgagcaccttgtgacccccgcccc240
tgcccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatcctata300
aaacggccccaccccatctcccttcgctgactctcttttcggactcagcccgcctgcccc360
caggtgaaataaacagccatgttgctcacacaaagcctgtttggtgtctcttcacatgga420
ctcgagtgaactttgatgccgtggctcggatcgggggacctcccttaggagatcaatccc480
ccgtcctcctgctctttgctccatgagaaagatccacctacgaccttaggtcctcagacc540
aaccagcccaagaaacatctcaccaattttaaatccagtaagccgcctctttttactctc600
ttctccaacctccctcactatccctcaacctctttctcctttcaatcttggcgccacact660
tcaatctctcccttctcttagtttcaattcctttcattttctggtagagacaaaggagac720
acgttttatctgtggacccaaaactccagcgctggtcacggactgggaaggcagccttcc780
cttgctgtttaatcattgcagggacacctctctgattattcacccacgtttcaagggtgt840
cagaccatgcagggatgcctgccttggtccttcacccttagcggcaagtcccgcttttct900
ggggaaggggaaagtaccccaaccccttctctctgtgtctctacccgttctctgcttttc960
tggggaaggggcaagtaccccaaccccttctctctgtgtctctaccccttccctgctttt1020
ctggggaaggggcaagtaccccaaccccttctcttcttgtctctaccccttctctgattt1080
tctggggcaggggcaagaacccctcaaccccttctccttcacccttagtggcaagtccca1140
cttttctgggggaggggaaagtacccctcaaccccttctccttcacccttagtggcaagt1200
cccgcttttctagggggcaagaacccccaatcccttatttccacaccccgacctcttatt1260
tctgtgacccaatcccttatttccacaccccaacctcttatctctgtgccccaatccctt1320
atttccatgccccaaccccccttcccacttttctagggggcaagaacccccaatccctta1380
tttccacaccctgacctcttatctctgtgccccaatcccttatttctgtgccccaaccct1440
ttctctgcttttctggagggcaagaaacccccaccccttctccgtgtctctactcttttc1500
tctgggcttgcctccttcactatgggcaagcttccaccttccattcctccttcttctccc1560
ttagcctgtattcttaagaacttaaaacctcttcaactctcacctgacctaaaatctaag1620
tgtctcattttcttctgcaatgcctcttgaccccaatacaaactctacagtagttccaaa1680
tagccggaaaacggcactttcaatttttccatcctacaagatctaaataattcttgtcat1740
aaaatgggcaaatggtctgaggtgcctgacatccaggcattcttttacacatcagtccct1800
tcctagtctctgtgcccagtgcaactcattctgaatcttccttctttccctcccgcctgt1860
cccctcagtcccaaccccaagcgtcactgagtctttctaatcttccttttctacagaccc1920
atctgacctctcccctccttgccaggccaagctaggtcccaattcttcctcagcctccgc1980
tcctccaccctgtaatctttttatcgcctcccctcctcacacctggtctggcttacagtt2040
tcgttctgtgactagccctcccccacctgcccagcaatttactcttaaaaaggtggctgg2100
agccaaaggcatagtcaaggttaatgctcctttttctttatcccaaatcagaagcgttta2160
ggctctttttcatcaaatataaaaacccagcccagttcatgtctcgttcggcagcaaccc2220
tgagatgctttacagccctagaccctaaaaggtcaaaaggccatcttattctcaatacac2280
attttattacccaatctgctcccgacattaaataaaactccaaaaattagaatctggccc2340
tcaaaccccacaacaggacttaattaacctcaccttcaaggtgtacaataataaaaaaaa2400
ggaagttgcaattccttgcctccactgtgagacaaaccccagccacatctccagcacaca2460
acaacttccaaatgcctgaaccgcagtggccagacattcctccagaacctcctcccccag2520
gagcttgctgcaagtgccagaaatctgaccaccagggcaaggaatgcctgcagcccaggg2580
attcctcctaagccatgtcccatctgtgcgggaccccactggaaatcggactgttcaact2640
cacctggcagccactcccagcgcccctggaactctggcccaaggctctctgactgactcc2700
ttcttggcttagtggctgaagactgacgctgcctgatcgcctcagaagccctgtagacca2760
ccatggacaccgagctttaggtaactctcacagtggagggtaagtctgtccccttcttaa2820
tcaatatggaggctacccactccacattaccttcttttcaagggcctgtttcccttgcct2880
ccataactgttgtgggtattgacagccaggcttctaaacctcttaaaactccccaactct2940
ggtgccaacttgaacaacactcttttatgcactcttttttagttatctccacctgcccag3000
ttcccttatcaggccgagatattttaaccaaattatctgcttccctgactattcctggac3060
tacagctgcatctcattgctgcccttcttcccaatccaaagcctcctttgcgtcctcctc3120
ttgtattcccccaccttaacccacaagtataagatacctctactccctccttggcgaccg3180
atcatgcaccccttaccatctcattaaaacctaatcacgcttacccgactcaatgccaat3240
atcccatcccacagcatgctttgaaaggattaaagcctgttatcactcacctgctacagc3300
atggccttttaaagcctataaactctccttacaattcccccgttttacctgtcctaaaac3360
cagacaaggcttacaacttagttcagaatctgtgccttatcaaccaaattgttttgccta3420
tccaccccgtggtgccaaacccatatactctcctatcctcaatacctccctctactaccc3480
attattctgttctggatctcaaacatgctttctttactattcctttgcactcttcatctc3540
agcctctctttgccttcacttagactgaccctgacacccattaggctcagcagcttacct3600
gggctgtgctgccgcaaggttccagggacagccctcattacttcagccaagctctttctc3660
atgatctactttctttccacccctccacttctcaccttattcaatatattgatgaccttc3720
ttctttgtagcccctcctttgaatcttctcaacaagacatacttctgctccttcagcatt3780
tattctccaaaggatatcgggtatccccctccaaagctcaaatttcttctccatccgtta3840
cctacctcggcataattcttcacaaaaacacaggtgctctccctgctgatggtgtctgat3900
taatctcccaaacctcaatcccttacaaaacaacaactcctttccttcctaggcatggtt3960
agtgcggtcagaattcttacacaagagccaggaccccaccctgtagcctttctgtccaaa4020
caacttgaccttactgttttagcctagccctcatgtctgcatgcagcagctgccgctgct4080
ttaataattttagaggccctaaaaatcacaaactatgttcaactcactctctacatttct4140
cataacttccaaaatctattttcttcctcatacctgacgcatatactttctgctccccgg4200
ctccttcagctgtactcattctttgttaagtcccacaattaccattgttcctggcccaga4260
cttcaatctggcctcccacattattcctgataccacacctgatccccatgactgcatctc4320
tctgatccacctgacattcaccccatttccccatattacaagccactagcccatctctta4380
gaacctctcatttcctttccattgtagaaatctatcctcaaggaaataacttctcagtgt4440
tccatctgctattctatctgctattctgctactcctcaaggatcattcaggcccctccct4500
tccctacacatcaagctcgaggatttgcccccgcccaggactggcaaattagctttactc4560
cacatgccccgagtcacaaaaactaaaatacctcttagtctaagtagacattttcactag4620
ataggtagaggcctttcctacagggtctgagaaggccaccgcagtcatttcttcccttct4680
gtcagacataattcctcagtttagccttcccacctctatacagtctgataacagaccagg4740
ctttattagtcaaattagccaagcagtttttcagtttatatcccttatagtcctctgtct4800
tcaagaaaagtagaacggactaaaggtcttttaaaaacacacctcaccaagctcagccac4860
caacttaaaaagaactggacaatacttttaccactttcccttctcagaagtcagacctgt4920
cctcagaatgctacaaggtacagtccatttaagctcctttttattaggccccagtctcat4980
cccagacaccagaccaacttagactgtgcccccaaaaaaacttgtcatccctactatttt5040
ccgtctagtcatactcctattctccgttctcaactactcatacatgccctgctcttgttt5100
acactgccagtttacactgtttctccaagccatcatggctgatatctcctcatgctatcc5160
ccaaactgccactcttaactcttgaagtaaataaataatcttcgctggaaggactatgct5220
gaacctccttaggcattctctaattagatgtcctagatcctcccaattcttagtcctttt5280
atacctgtttttctccttctcttattccatttagtttttcagttcatacaaaaccgtatc5340
caggccatcaccaatctttctgtatgacaaatgtttcttctaacaaccccctcaatgtca5400
ccccttaccacaagacctcccttcagcttaatctctcccactctaggttcccacgccgcc5460
cctaatcccgcttgaagcagccctgagaaacatcgcccattctctctccataccaccccc5520
caaaaattttcaccgccccaacacttcaacacaattttgttttatttttcttattaatat5580
aagaaggcaggaatgtcaggcctctgagcccaagccaagccatcgcatcccctgtgactt5640
gcacgtatacgcccagatggcctgaagtaactgaagaatcacaaaagaactgaaaaggcc5700
ctgccccgccttaactgatgacattccaccatggtgatttgttcttgccccaccttaact5760
gagtgattaaccctgtgaatttccttctcctggctcagaagctcccccactgagcacctt5820
gtgacccccgcccctgcccaccagagaacaaccccctttgactgtaattttccattacct5880
tcccaaatcctataaaacggccccacccctatctcccttcgctgactctcttttcggact5940
cagcccgcctgcccccaggtgaaataaacagccatgttgctcacacaaagcctgtttggt6000
gtctcttcacacggacgcgcatgaaa6026
<210>7
<211>5535
<212>dna
<213>智人
<400>7
aactgaagatccacaaaagaagtaaaaacagccttaactgatgacattccaccattgtga60
tttgttcctgccccaccctaactgatcaatgtactttgtaatctcccccacccttaagaa120
ggttctttgtaattctccccacccttgagaatatactttgtgagatccacccctgcccac180
cagaggacaaccccctttgactgtaattttccattaccttcccaaatcctataaaacggc240
cccacccgtatctcccttcgctgactctcttattggactcagcccacctgcacccaggtg300
aaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacacagacgcgc360
atgaaatttggtgccgtgactcggatcgggggacctcccttgggagatcaatcccctgtc420
ctgctgctctttgctccgtgagaaagatccacctatgacctcaggtcctcagaccgacca480
gcccaagaaacatcgcaccaatttcaaatccggtaagcggcctctttttactctcttctc540
caacttccctcactatccctcaacctctttctcctttcaatcttggcgctacgcttcaat600
ctctcccttctcttaatttcaattcctttcattttctggtagacacaaaagagacgtttt660
atccgtggacccaaaactccggcgccggtcacggactgggaaggcagccttcccttggtg720
tttaatcaatgcagggacgcctctctgattatacacccacgtttcaagggtgtcagacca780
cgcagggacacctgccttggtccttcacccttagcggcaagtcctgcttttctggggaag840
gggcaagtagcccaaccccttctctccttgtctctaccccttctctgctttcctggggca900
ggggcaagtacccctcaaccccttctccttcacccttagcggcaagtcccgctttcctgg960
ggcaggggcaagtacccctcaaccccttctccttcacccttagcggcaagtcctgctttt1020
ctagggggcaagaacccccaaaccacttccctccgtgtctctacgctctctgttctctgg1080
gcttgcctccttcactatgggcaagcttccaccttccattcctccttcttctcccttagc1140
ctgtgttcttaagaacttaaaacctcttcaactctcacctgacctaaaatctaagcatct1200
tattttcttctgcaatgccgcttgaccccaatacaaactcgacagtagttccaaatagcc1260
agaaaacagcactttcaatttttctgtcctacaagatctaaataattcctgtcgtaaaat1320
gggcaaattgtctgaggtgcctgacgtccaggcattcttttacacatcagtccattccta1380
gtctctgtgcccaatgcaactcgtcccaaatctcccgcctgtcccctcagtcccaacgcc1440
aagcatcgctgagtctttctaatcttccttttctacagacccatctgacctctcccctcc1500
tagccaggccaagctaggtcccaattcttcctcagcctccactcctccaccctataatct1560
ttttatcgcttcccctcctcacacctggtcgggcttacagtttcattccgtgactagccc1620
tcccccacctgcccagcaatttattcttaaaaaggtggctggagctaaaggcatagtcaa1680
ggttaatgctcctttttatttatcccaaatcagatagcgtttaggctttttcatcaaata1740
taaaaaccctgcccagttcatggctcgttcggcagcaaccctgagactctttacagccct1800
agaccctgaaaggtcaaaaggccatcttattctcaatatacattgtattacccaatctgc1860
tcccgacattaaataaaactccaaaaattaaattctggccctcaaaccccacaacaggat1920
ttaattaacctcgccttcaaggtgtacaataatagaaaaaagttgcaattccttgcctcc1980
actgtgagacaaaccccagccacatctccagcacacaagaacttccaaacgcctgaacca2040
cagcagccaggcttcctccagaacctcctcccccaggagcttgctacaagtgccagaaat2100
ctgaccaccaggccaaggaatgcctgcagcccaggattcctcctaagccatgtcccatct2160
gtgcgggaccccactggaaactggactgttcaactcacctggcagccactcccagagccc2220
ctggaactctggcccaaggctctctgactgactccttctcggcttagcggctgaagactg2280
atgctgcccgatcgcctcggaagccccgtagaccatcacggacaccgagctttgggtaac2340
tctcacagtggaaggtaagtccgtccccttcttaatcaatatggaggctacccactccac2400
attaccttcttttcaagggcccgtttccgttgcctccataactgttgtgggtattgacgg2460
ccaggcttctaaacctcttaaaactccccaactctggtgccaacttagacaatactcttt2520
taagcactcctttttagttatccccacctgcccagttcccttattaggctgagacacttt2580
aactaaattatctgcttccctgactattcctggactacagctacatctcattgccgccct2640
tcttcccaatccaaagcctcctttgtgtcctcctcttatatccccctaccttaacccaca2700
agtataagatacctctactccctccttggcgaccgatcatgcaccccttaccatctcatt2760
aaaacctaatcacccttaccccgctcaatgtcaagatcccatcccacagcacgctttaaa2820
aggattaaagcctgttatcactcgcctgctacagcatgaccttttaaagcctataaactc2880
tccttaccattcccctgttttacctgtcctaaaaccagacaaggcttacaagttagttca2940
gaatctgcgccttatcaaccaaattgttttgcctatccaactcgtggtgccaaatccata3000
tactctcctatcctcaatacctctctctactacccattattctgttctagatctcaaaca3060
tgctttctttactattcctttgcacgcttcatcccagcctctctttgctttcacttagac3120
tgaccctgacacccatcaagctcagcaaattaccttggctgtactgccgcaaggcttcac3180
agacagcccccattacttcagtcaagcccaaatttcaccctcatctgttacctatctcgg3240
ccaaattctcataaaaacacacgtgctttccctgctgatcgtgtctgattaatctcccaa3300
acctcaatccctttcaaaacaacaactcctttccttcctaggcatggttagtgcggtcag3360
aattcttacacaagagccaggaccgcaccctgtagcctttctgtccaaacaacttgacct3420
tactgttttagcctagccctcatgtctgcgtgcagcggctgccgctgctttaatactttt3480
agaggccctcaaaatcacaaactatgctcaactcactctctacatttctcataacttcca3540
aaatctattttcttcctcatacctgatgcatatactttctgcttcccggctccttcagct3600
gtactcactctttaagtcccacaattaccattgtttctggcccggacttcaatccggcct3660
cccacattattcctgataccacacctgacacccatgactgtatctctctgatccacctga3720
tattcaccccatttccccatatttccctctttcctgttcctcaccctgatcacgcttgat3780
ttattgatggcagttccaccaggcctaatcgccgcataccagcaaaggcaggttatgcta3840
tagtacaagccactagcccacctctcagaacctctcatttcctttccatcgtggaaacct3900
gtcctcaaggaaataacttctcagtgttccatctgctattctactactcctcagggatta3960
ttcaggccccctcccttccctacacatcaagttcgaggatttgcccctacccaggactgg4020
caaattagctttactcaacgtgcctgagtcaggaaactaaaatacctcttagtccaaata4080
gacactttcactgaataagtaaaggtctttcctacagggtctgagaaggccaccgcagtc4140
atttctttccttctgtcagacataattcctcagtttagccttcccacctctatacagtct4200
gataacggaccagcctttattagtcaaatcagccaagcagtttttcaggctcttagtagg4260
tttcagtgaaaactttatatcccttacggtcctccgtcttcaagaaaagtagaacggact4320
aaagatcttttaaaaacacagctcaccaagctcagccaccaacttaaaaggactgacaat4380
acttttaccacttttgcttctcagaattcaggcctgtcctcaatgctacaaggtacagcc4440
catttaagctcctgtatagacgctcctttttattaggccccagtctcatttgacaccaga4500
ccaacttagactgtgccccaaaaaaacttgtcatccctactatcttttgtccagtcatac4560
tcctattcaccgttctcaactactcatacatgccctgctcttgtttacactgccggttta4620
cactgtttctccaagccatcacagctgatatctcctggtgctatccccaaactgccactc4680
taaactcttgaagtaaataaataatctttgctggcaggactatgctgaatctccttaggc4740
actctctaatcagatgtcctaggtcctcccaattcttagaccttttatacctgtttttct4800
ccttctcttattccatttagtttctcaattcatccaaaaccgtatccaggccatcaccaa4860
tcattctatacaacaaatgtttcttcttacatccccacaatatcaccctttaccacaaga4920
cctcccttcagcttaatctctcccactctaggttcccacgccgcccctaatcctgcttga4980
agcagccctaagaaacattgcccattctctctccataccacccccacaaaaattttcgcc5040
gccccaacacttcaacactattttgttttgtcttattaatataagaaggcaggaatgtca5100
ggcctctgagcccaggccaggccatcgcatcccctgtgacttgcacgtatacatccagat5160
ggcctaaagtaactgaagatccacaaaagaagtaaaaacagccttaactgatgacattcc5220
accgtgtgatttgttcctgccccaccctaactgatcaatgtactttgtaatctcccccac5280
ccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagatccacc5340
cctgcccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatccta5400
taaaacggccccacccatatctcccttcgctgactctcttttcggactcagcccacctgc5460
acccaggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcaca5520
cggacatgtatgaaa5535
<210>8
<211>5575
<212>dna
<213>智人
<400>8
gtcagacctctgagcccaagctaagccatcgcatcccctgtgacttgcacgtatacatcc60
agatggcctgaagtaactgaagatccacaaaagaagtaaaaatagccttaactgatgaca120
ttccaccattgtgatttgttcctgccccaccctaactgatcaatgtactttgtaatctcc180
cccacccttaagaaggttctttttaattctccccacccttgagaatgtactttgtgagct240
ccacccactgtctgcaaaacattgctcttaacttcagcgcctatcccaaaacctataaga300
actgatgataatccaccaccctttgctgactctcttttcggactcagcccgcctgcaccc360
aggtgaaataaacagccatgttactcacacaaagcctgtttggtggtctcttcacacgga420
cgtgcatgaaatttggtgccgtgactcggatcgggggacctcccttgggagatcaatccc480
ccgtcctcctgctctttgctctgtgagaaagatccacctacgacctcaggtcctcagact540
gaccagcccaagaaacatctcaccaatttgaaatccggtaagcagcctctttttactctc600
ttctgcaacctccctcactatccctcaacctctttctcctttcaatcttggcaccacatt660
tcaatctctcccttctcttaatttcaattcctttcattttctggtagagacaaaggggac720
acgttttatccgtggacccaaaactccggcgccggtcacggactgggaaggcagccttcc780
cttggtgtttaatcattgcaaggatgcctctctgattattcacccacgtttcaagggtgt840
cagaccacacagggacgcctgccttggtccttcacccttagcggcaagtcccgcttttct900
ggggaaggggcaagtaccccaaccccttctctccttgtctctatcccttctctgcttttc960
tggggaaggggcaagtaccccaaccccttctctccgtgtctctaccccttctctccgtgt1020
ctctaccccttctctgcctttctgggggaggggcaagtacccctcaaccccttcttcacc1080
cttagcggcaagtcccgcttttctagggggcaagaacccccaattccttatttccacacc1140
ccgacctcttatctctgtgccccaattccttatttctgcaccctgacctcttatctctgt1200
gccccaatcccttatttctgcaccccgacctctcaactctgtgccccaatcccttatttc1260
tgcaccccaacctcttatctctgtgccccaatcccttatttccgtgccctgacccccctt1320
cccgcttttctggagggtaagaacccccgaaacccttccctccatgtctctacattctct1380
tttctctaggtttgcctccttcactatgggcaaccttccaccctccattcctccttcttc1440
tcccttagcctgtgttctcaagaacttaaaacctcttcaactcacacctgacctaaaacc1500
taaatgccttattttcttctgcaatgccgcttgaccccaatacaaactcgacagtagctc1560
caaatagccagaaaacggcactttgaatttttccatcctgcaagatctaaataattcttg1620
tcgtaaaataggcaaacggtctgagttgcctgacgtccaggcattcttttacacatcagt1680
cccttcctagtctttgtccccaatgcaactcgtcccaaatcttccttctttcccttccgc1740
ctgtcccctcagtcccaaccccaagcgtcgctgagtctttctaatcttccttttctacag1800
acccatctgacctttcccctcctccccaggctgctcctcgccaggccgagctaggtccca1860
attcttcctcagcctctgctcctccaccctataatccttttatcacctcgcctcctcaca1920
cctggtccagcttacagtttcgttccgtgactagccctcccccacctgcccagcaattta1980
ctcttaaaaaggtggctgaagctaaaggcatagtcaaggttaatgctcctttttctttat2040
cccaaatcagaagcatttaggctctttttcatcaaatataaaaacccagcccagttcatg2100
gctcgtttggcagcaaccctgagacgctttacagccctagaccctaaaaggtcaaaaggc2160
cgtcttattctcaatatacattttactacccaatctgctcccgacattaaataaaactcc2220
aaaaattggaatctggccctcaaaccccacaacaggacttaattaacctcaccttcaagg2280
tgtacaataacagaaaaaagttgcaattccttgcctccactgtgagacaaaccccagcca2340
catctccagcacacaagaacgtccaaacgcctgaaccacagcagccaggggttcctccag2400
aacctcctcccccaggagcttgctacacgtgccggaaatctggccactgggccaaggaat2460
gcccgcagcccgggattcctcctaagctgcgtcccatctgtgtgggaccccactgaaaat2520
ccgactgttcaactcacctggcagccactcccagagcccctggaactctggcccaaggct2580
ctctgactgactccttcccagatcttctcggcttagcagctgaagactgacactgcccga2640
ttgcctcggaagccccctaaaccatcacggatgccgagcttcaggtaactctcacggtag2700
aaggtagtaagcgcgtccccttcttaatcaatacggaggctacccactccacattacctt2760
cttttcaaaggcctgtttcccttgcctccataactgttgtaagtattgacggccaggctt2820
ctaaacctcttaaaactccccaactctggtgccaacttagacaatactcttttaagcact2880
cctttttagttatccccacctgcccagttcccttattaggctgagacactttaactaaat2940
tatctgcttccctgactattcctggactacagccacatctcattgccgcccttcttccca3000
atccaaagcctcctttgcgtcctcctcttgtatccccctaccttaacccacaagtataag3060
atacctctactccctccttggtgaccgatcatgtaccccttaccgtctcattaaaaccta3120
atcacccttaccccactcaatgtcaagatcccatcccacagcacgctttaaaaggattaa3180
agcctgttatcactcgcctgctacagcatggccttttaaagcctatgaactcttcttacc3240
attcccccattttacctgtcctaaaaccagacaagccttacaagttagttcagaatctgc3300
gccttatcaaccaaattgttctgcctatccacccggtggtgccaaacccatactcgatac3360
ctccctctactacccattattctgttctagatctcaaacatgctttctttactattcctt3420
tgcacccttcatcccagcctctctttgctttcacttagactgaccctgacacccattagg3480
ctcagcaaattacctcggctgtactgccgcaaggcttcacagacagcccccattacttca3540
gtcaagcccaaatttcatcctcatctgttacctatctcagcataattctcataaaaatac3600
acgtgctctccctgctgatcgtgtctgattaatctcccaaacctcagtcccttacaaaat3660
aacaactcctttccttcctaggcatggttagtgcagtcagaattcctacacaagagccag3720
gacaggactgcaccctgtagcctttctgtccaaacaacttgaccttactgttttagccta3780
gccctcatgtctgtgtgcagcggctgccgctgctttaatactgttagaggccctaaaaat3840
cgcaaactatgctcaactcactctctacatttctcataacttccaaaatctattttcttc3900
ctcatacctgacgcatatactttctgctccccagctccttcagctgtactcactctttgt3960
taagtcccacaattaccattgttcctggcccggacttcaatctggcctcccacattattc4020
ctgataccacacctgacccccatgactgtatctctctgatccacctgatattcaccccat4080
ttccccatatttccttctttcctattcctcaccctgatcacgcttgatttattgatggca4140
gttccaccaggcctaatcgccacacaccagcaaaggcaggctatgctatagtacaagtca4200
ctagcccgcctctcagaacctctcatttcctttccatcgtggaaatctatcctcaaggaa4260
ataacttctcagtgttccatctgctattctactactcctcagggattattcaggccccct4320
cccttccctacacatcaagctcaaggatttgcccccacccaggactggcaaattagcttt4380
actcaacatgtcccgagtcaggaaactaaaatacctcttagtctaaatagacactttcac4440
tgaataagtaaaggcctttcctacagggtctgagaaggccaccacagtcatttcttccct4500
tctgtcagacataattcctcagtttagccttcccacctcaatacagtctaataacagacc4560
atcctttactagtcaaatcagccaagcagcttttcaggctcttagtattcagtgaaacct4620
ttatatcccttacggtcctccatcttcaagaaaaggagaacggactaaaggtcttttaaa4680
aacacacctcaccaagctcagccaccaacttaaaaaggactggacaatactttcaccact4740
ttcgtttctcagaattcaggcctgtcctcagaatgctacaaggtacagcccatttaagct4800
cctgtatagacgctcctttttattaggccccagtcccattcgacaccagaccaacttaga4860
ctgtgccccaaaaaaacttgtcatccctactatcttttgtctagtcatactcctattcac4920
cattctcaactactcatacatgccctgctcttgtttacactgctggtttatactgtttct4980
ccaagccatcacagctgatatctcctggtgctatccccaaactgccactctaaactcttg5040
aagtaaataaataatctttgccggcaggactatgctgaatctccttaggcactctctaat5100
cagatgtcctaggtcctcccaattcttagaccttttatacctgtttttctccttctctta5160
ttccatttagtttctcaattcatccaaaaccatatgcagtccatcaccaatcattctata5220
cgacaaatgtttcttctaacatccccacaatatcaccccttaccacaagacctcccttca5280
gcttaatctctcccactctaggttcccacgccgcccctaatcccgcttgaagcagccctg5340
agaaacatcgcccattctctctccattccaccccccaaaaattttcgccgccccaacact5400
tcaacactattttgttttatttttcttattataagaaggcaggaatgtcaggcctctgag5460
cccaagccaagccatcgcatcccctgtgacttgcacgtatacatccagatggcctgaagt5520
aactgaagatccacaaaagaaataaaaatagccttaactgatgacattccatcat5575
<210>9
<211>6045
<212>dna
<213>智人
<400>9
gtcaggcctctgagcccaggctaagccatcatatcccctgtgaccggcacctatacatcc60
agatggcctgaagcaactgaagatccacaaaagaagtgaaaatagccttaactgatgaca120
ttccaccattgtgatttgtttctgtcccaacctaactgatcaatgtacttggtaatctcc180
cccacccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagat240
ccaccccctgcctgcaaaacattgctcctaacaccaccgcctatcccaaaacctataaga300
accatgataatccaccaccctttgctgacccttttcggactcagcccgcctgcacccagg360
tgaaataaacagccttgttgctgacacaaagcctgtttggtggtctcttcacacggacgc420
atgaaacaatatgtttactgcagcactacttatagttttttattatttctttatttattt480
tttgagacggagtctctctctgttgctcaggctggagtgcagtggtgcgatcttggctca540
ctgcaacctccacctcctggattcaagcgattttcctgcctcagcctcccgctgagtggt600
aggcgcccgccaccactcctagcaaaattttatttatttatttttattttttagtagaga660
cagggtttcgtcatgttggccaggctggtcttgaactcctgacctcaggtgatccacctg720
tctcggcctcccaaagtgctgggattacaggtgtgagccaccgtgcctggacactttttt780
atttttaacatcaaacatgttttaaagtattttaaaggacctaatagaagaatagcctat840
gtatttacccatacataggtaaatgttcttcttcctttattcctcctgtttcaagtttcc900
tttttatataattccccttccgtctcaaaaaaattcctctaaaatctttgaaaggtaggg960
taccagtgacaaattatcttagtttctcttcctctgagaatgtctttatttcacctcatt1020
cctggagaatatttttactagatctgaaattccatattgaaccattctttccttcccaca1080
atttaacaatagtcttccattctcttctgtgtgccatggtttctgatgtgaaatccgcag1140
ttataggccaggtgcggtggctcactcctgtaatcccagcactttgggaggctgaggcgg1200
gtggatcacctgaggtcagtgtcaggcctctgagcccaggccaggccatcgcatcccctg1260
tgacttgcaggtatacatccagatggcctgaagtaactgaagatccacaaaagaagtaaa1320
aacagccttaactgatgacattccaccattgtgatttgttcctgccccaccctaactgat1380
caatgtactttgtaatctcccccacccttaagaaggttctttgtaattctccccaccctt1440
gagaatgtacttggtgagatccacccctgcccaccagagaacaaccccctttgactgtaa1500
ttttccattaccttcccaaatcctataaaacggccccacccctatctcccttcgctgact1560
ctcttttcggactcagcccgcctgcgcccaggtgaaataaacagccatgttgctcacaca1620
aagcctgtttggtggtctcttcacacggatgcgcatgaaatttggtgccgtgactcagat1680
caggggacctcccttgggagatcaatcccctgtcctcctgctctttgctccgtgagaaag1740
atccacctatgacctcaggttctcaaaccgaccagcccaagaaacatctcaccaatttca1800
aatctggtaagcagccttttactctcttctccaatctccctcactatccctcagcctctt1860
tctcctttcaatcttggtgctacacttcaatctctcccttctcttaatttcaattccttt1920
cattttctggtagagacaaaagagacacgttttatccgtggacccaaaactccggcgccg1980
gtcacggactgggaaggcagccttcccttggtgtttaatcattgcagggacacctctctg2040
attatacactcacgtttcaagggtgtcagaccacgcagggacgcctgccttggtccttca2100
cccttagcggcaagtcccgcttttctggggaaggggcaagtaccccaaccccttctctcc2160
ttgtctctaccccttctctgcttttctggggaaggggcaagtaccccaaccccttctctc2220
cttgtctctaccccttctctgctttcctggggcaggggcaagtacccctcaaccccttct2280
ccttcgcccttagcggcaagtcccgctttcctagggggcaagaaacccccaatcgcttat2340
ttctgcaccccaacctcttatctctgtgccccaatcccttatttccgcaccctgacctct2400
tatctctgtgccccaatcccttatttccgtgccccaaccccttctctgcttttctggagg2460
gcaagaaccccccccctccttctccgtgtctctactcttttctctgggcttgcctccttc2520
actatgggtaagcttccaccttccattcctccttcttctcctttagcctgtgttctcaaa2580
aacttaaaacctcttccactcacacctgacctaaaacctaaatgccttattttcttctgc2640
aatgccgcttgactccaatacaagctcgacagtagttccaaatagctggaaaacggcact2700
ttcaatttttccatcctacaagatctaaataattctcgtcgtaaaatgggcaaacggtct2760
gaggtgcctgacgtccaggcattcttttacacatcagtcccttcctagtctctgtgccca2820
atgcaactcgtcccaaatcttccttctttccctcccgcctgtcccctcagtcccaacccc2880
aagcgtcgctgagtctttctaatgttccttttctacagacccatctgacctctcccttcc2940
tccccaggctgctcctcaccaggccgagctaggtcccaattcttcctcagcctccgctcc3000
tgcaccctataatcttttcatcgcctcccctcctcacacctgctctggcttacagtttcg3060
ttccgtgactagccctcccccacctgcccagcaatttactcttaaaaaggtggctggagc3120
caaaggcatagtcaaggttaatgctcctttttctttatcccaaatcagatagcgtttagg3180
ctctttttcatcaaatataaaaatccagcccagttcatggctcgctcggcagcaaccctg3240
agacactttacagccctagaccctaaaaggtcaaaaggccgtcttattctcaatatacat3300
tttattacccaatctgttcccgacattaaataaaactccaaaaattaaattccagccctc3360
aaaccccacaacacgatttaattaacctcgccttcaaggtgtaccataatagaaaaaagt3420
tgcaattccttgcctccacggtgagacaaaccccagccacatctccagcacacaagaact3480
tccaaacgcctgaaccgcagcggccaggcgttcccccagaacctcctcccccaggagctt3540
gctacaagtgccagaaatctgaccaccaggccaaggaatgcccgcagcctgggattcctc3600
ctaagccgcatcccatctgtgtgggaccccactgaaaatcggactgttcaactcacctgg3660
cagccactcccagagcccctggaactccggcccaaggctctctgactgactccttcccag3720
atcttctcggcttagcggctgaagactgacactgcccgatcgcctcggaagccccctaga3780
ccatcacggacaccgagctttgggtaactctcacagtggaaggtaagtccgtccccttct3840
taatcaatatggagtctacccactccacattaccttcttttcaaggcctgtttccctgcc3900
tccataactgttgtgggtattgacggccaagcttcaaaacccctgaaaactcccccactc3960
ttgtgccaacttggacaacactcttttatgcactcttttttagttatccccacctgccca4020
gttcccttatcaggccgagatattttaaccaaattgtatgcttccctgactattcctgga4080
ttacagccgcatctcattgccgcccttctccccaacccaaagcctccttcgcatcttcct4140
ctcatatcccccaaccttaacccacaagtatgggacatctctactccttccctggcaact4200
gatcacatgcccattaccatcccattaaaacctaatcaccctcaccccgctcaacgccca4260
tatcccatcccacagcatgctttaaaaggattaaagcctgttaccactcgcctgctacag4320
catgggcttctaaaacctataaactctccttacaattcccccattttacctgtccaaaaa4380
ctggataagtcttacagattagttcaggatctgcgtcctatcaaccaaattgttttgcca4440
tccaccctgtggtgcccaacccgtacactcttttgtcctcaatccgttcctccacaattc4500
actattctgttctccaccttaaagatgcttttttcactattcccctgcacccctcgtccc4560
agcctctctttgctttcacttagactgaccctgacacccattaggctcagcaaattacca4620
aggctgtactgctgcaaagcttcacagacagcccccattacttcaatcaagcccaaattt4680
cttcctcatctgttacttatctcggcataattctcacaaaaacacacgtgctttccctgc4740
caatcgtgtccgactgatctctcaaaccccagcaccttctacaaaacaacaactcctttc4800
cttcctaggcatggttagcgtggtcagaattcttacacaagagccaggaccacactctgt4860
agcctttctgtccaaacaacttgaccttactgttttagcctagccctcatgtctgcgtgc4920
agcggctgctgctgctttaatacttttagaggccctcaaaatcacaaactttatcagtcc4980
tccaggcccaagttgactcgttagctgcagttgtcctccaaaaccgccgaggccttgact5040
gacttactgctgagaaaggaggactctgcatattcttaaatgaggagtgttgtttttacc5100
taaatcaatctggcctggtgtatgacaacataaaaaaactcaaggatagagcccaaaaac5160
ttgccaaccaagcaagtaattatgctgaacccccttgggcactctctaattggatgtcct5220
gggtcctcccaattcttagtcctttaatacccatttttctcctccttttatttggacctt5280
gtatcttccgtttagcttctcaattcatccaaaaccgtatccaggccatcaccaatcatt5340
ctatacgacaaacgtttcttctaacatccccacaatgtcaccccttaccacaagacctcc5400
cttcagcttaatctctcccactctaggttcccacgccgcccctaatcccgctcgaagcag5460
ccctgagaaacatcgcccattctctctccataccaccccccaaaaattttcgccgctcca5520
acacttcaacactattttgttttatttgtcttattaatataagaaggcaggaatgtcagg5580
cctctgagcccaggccaggccatcgcatcccctgtgacttgcaggtatacatccagatgg5640
cctgaagtaactgaagatccacaaaagaagtaaaaacagccttaactgatgacattccac5700
cattgtgatttgttcctgccccaccctaactgatcaatgtactttgtaatctcccccacc5760
cttaagaaggtactttgtagtctcccccacccttaagaaggttctttgtaattctcccca5820
cccttgagaatgtacttggtgagatccacccctgcccaccagagaacaaccccctttgac5880
tgtaattttccattaccttcccaaatcctataaaatggccccacccctatctcccttcgc5940
tgactctcttttcggactcagcccacctgcacccaggtgaaataaacagctttattgctc6000
acacaaagcctgtttggtggtctcttcacacggacgtgtatgaaa6045
<210>10
<211>4776
<212>dna
<213>智人
<400>10
gtcaggcctctgagcccaggccaggccatcgcaccccctgtgacttgcacgtatacatcc60
agacggcctgaagtaactgaagatccacaaaagaagtaaaaacagccttaactgatgaca120
ttccaccattgtgatttgttcctgccccaccctaactgatcaatgtactttgtaatatcc180
cccacccttaaggtactttgtagtctcccccacccttaagaaggttctttgtaattctcc240
ccacccttgagaatgtactttgtgagatccacccctgcccaccagagaacaacccccttt300
gactgtaattttccattaccttcccaaatcctataaaatggccccacccctatctccctt360
cgctgactgtcttttcggactcagcctgcctgcacccaggtgaaataaacagccatgttg420
ctcacacaaagcctgtttggtggtctcttcacagggacacgcatgaaatttggtgccgtg480
actcggatcgggggacctcccttgggagatcaatcccccgtcctcctgctctttgctcca540
tgagaaagatccacctacgacctcaggtcctcagaccgaccagcccaagaaacatctcac600
caatttcaaatccggtaagcggcctctactcttctccaacctccctcactatccctcaac660
ctctttctcctttcaatcttggagccacacttcaatctctcccttctcttaatttcaatt720
cctttcattttctggtagagacaaaagagacatgttttatccgtgaacccaaaactctgg780
cgccggtcacggactgggaaggcagccttcccttggtgtttaatcattgcagggatgcct840
ctctgattatacactcacgtttcaagggtgtcagaccacgcagggacgcctgccttggtc900
cttcacccttagcggcaagtcccactttcctggggcaggggcaagtacccctcaacccct960
tccccttcaccctcagcggcaagtcctgctttcctggggcaggggcaagtacccctcaac1020
cccttccccttcaccctcagcggcaagtcctgctttcctggggcaggggcaagtacccct1080
tccccttcaccctcagcggcaagtcctgctttcctggggcaggggcaagtacccctcaac1140
cccttctccttcatccttagcagcaagtcccgctttcctagggggcaagaaccccccaat1200
cacttatttccacaccccaacctcttatctctgtgccccaatcccttatttccgcaccct1260
gacctcttatttccatgccccaaccccttctctgcttttctggagggcaagaacccccca1320
ccccttctctgtgttgctactcttttctctgggcttgcctccttcactatgggtaagctt1380
ccaccttccattcctccttcttctcccttagcctgtgttctcaaaaacttaaaacctctt1440
caactcacacctgacctaaaacctaaatgccttactttcttctgcaatgccgcttgactc1500
caatacaagctcgacagtagttccaaatagccggaaaacggcactttcaatttttccatc1560
ctacaagatctaaataattcttgtcgtaaaatgggcaaatggtctgaggtacctgaagtc1620
caggcattcctttacacatcagtcccttcctagtctctgtgcccagtgcaactcgtccca1680
aatctttcttctttccctcccgcctgtcccctcagtcccaaccccaagtgtcgctgagtc1740
tttctgatcttccttttctacagacccatctgacctctcccctcctcgccagcccaagct1800
aggtcccaattcttcctcagcctctgctcctgcaccctgtaatctttttatcgcctcccc1860
tcctcacacctggtcgggcttacagtttcgttccgtgactagccctcccccacctgccca1920
gcaatttactcttaaaaaggtggctggagccaaaggcatagtcaaggttaatgctccttt1980
ttctttatcccaaatcagatagcgtttaggctctttttcatcaaatataaccctgagatg2040
cttcacagccctagaccctaaaaggtcaaaaggcaatattattctcaatatacattttat2100
tacccaatctgctcccgacattaaatctccaaaaattaaattccggccctcaaaccccac2160
aacagaatttaattaacttcaccttcaaggtgtacaataatagaaaaagttgcaattcct2220
tgcctccactgtgagacaaaccccagccacatctccagcacacaagaacttccaaacgcc2280
tgaaccacagcggccaggcgttcctccagaacctccttccccaggagcttgctacaagtg2340
ccagaaatctgaccaccaggccaaggaatgcatgcagcccaggattcctcctaagccgtg2400
tcccatctgtgcgggaccccactggaaattggactgttcaactcacctggcagccactcc2460
cagagtccctggaactctggcccaaggctctctgactgactccttctcggcttagcggct2520
gaagactgatgctgcccgatcgcctcggaagccccgtagaccatcacggacgccgagctt2580
ccggtaactctcacagtggaaggtaagcccgtccccttcttaatcaatacggaggctacc2640
cgctccacattaccttcttttcaagggcctgtttcccttgcctccataactgtgggtatt2700
gacagccaggcttctaaacctcttaaaactcccccactctggtgccaacttggacaacac2760
tcctttatgcactcttttttagttattcccacctgcccagttcccttattaggccgagat2820
attttaaccaaattatctgcttccctgactattcctggactacagccgcatctcattgcc2880
gaccttctccccaactcaaagcctccttcgcgtcttcctcttatatccccccaccttaac2940
ccacaagtatgggacatctctactccttccatcacccttaccccgctcaacgccaatatc3000
ccatcccacagcatgctttaaaaggattaaagcctgttatcactcgcctgctacagcatg3060
ggcttctaaaacctataaactcttacaattcccccattttacctgtccaaaaaccggata3120
agtcttacagattagttcaggatctgcgtcttatcaaccaaattgttttgcctatccacc3180
ctgtggtgcccaacccgtacactcttttgtcctcaatacgttcctccacaactcactatt3240
ctgttctccatcttaaagatgcttttttcactattcccctgcacccctcgtcccagcctc3300
tctttgctttcacttagactgaccctgacaccccattaggctcagcaaattacctgggct3360
gtactgctgcaaagcttcacagacagcccccattacttcagtcaagcccagatttcttcc3420
tcatctgttacctatctcggcgtaattctcgtaaaagcacacgtgctttccctgccaatc3480
gtgtccgactgatctctcaaaccccagcaccttctacaaaacaacaactcttttccttcc3540
taggcatggttagcgtggtcggaattcttacacaagagccaggaccacaccctgtagcct3600
ttctgtccaaacaacttgaccttactgttttagcctagccctcatgtctgcgtgcagcag3660
ctgctgctgctttaatacttttagaggccctcaaaatcacaaactttatcagtcctccag3720
gcccaagttgactctttagctgcagttgtcctccaaaaccgccgaggccttgacttactt3780
actgctgaaaaaggaggactctgcatattcttaaatgaggagtgttgtttttacctaaat3840
cagtctggcctggtgtatgacaacataaaaaaactcaaggatagagcccaaaaacttgcc3900
aaccaagcaagtaattacgctgaacccccttgggcactctctaattggatgtcctgggtc3960
ctcccaattcttagtcctttaatacccatttttctcctccttttattcagaccttgtatc4020
ttccatttagcttctcagttcatccaaaactgtatccaggccatcaccaatcattctata4080
tgacaaatgtttcttctaacatccccacaatatcatcccttaccacaagacttcccttca4140
gcttaatctctcccactttatgttcccacgccgccccaatcccacttgaagcagccctga4200
gaaacatcgcccattctctctccataccaccccccaaaaattttcgccgctccaacactt4260
caacactattttgttttatttgtcttattaatataagaaggcaggaatgtcaggcctctg4320
agcccaggccaggccatcgcatcccctgtgacttgcacgtatacatccagatggcctgaa4380
gtaactgaagatccataaaagaagtaaaaacagccttaactgatgacattccaccattgt4440
gatttgttcctgccccaccctaactgatcaatgtactttgtaatatcccccacccttaag4500
gtactttgtagtctcccccacccttaagaaggttctttgtaattctccccacccttgaga4560
atgtactttgtgagatccacccctgcccaccagagaacaaccccctttgactgtaatttt4620
ccattaccttcccaaatcctataaaatggccccacccctatctcccttcgctgactgtct4680
tttcggactcagcctgcctgcacccaggtgaaataaacagccatgttgctcacacaaagc4740
ctgtttggtggtctcttcacacggacgcacatgaaa4776
<210>11
<211>935
<212>dna
<213>智人
<400>11
gtggggaaaagaaagatcagattgttactgtgtctgtgtagaaaaggaagacataagaaa60
ctccattttgatctgtactaagaaaaattgtttctgctttgagatgttgttagcctataa120
ctttagccccaactctgtgctcacagaaacatgcgctgtaatgaatcaaagtttaatgga180
tttagggctgtgcaggatgtgccttgttaacaatatgtttgcaggctgtatgcttggtag240
aagtcatcgccattctccattctcgattaaccagggacacaatgcacagcagaaagctgc300
agggacctctgcccaagaaagcctgggtattgtccaaggtttcccccccactgagacagc360
ctgagatatggcctcatgggaagggaaagacctgactgtcccccagcccgacacctgtaa420
agggtcggtgctgaggaggaatagtgaaggagggaggcctctttgcagttgagataagag480
gaaggcttctgtctcctgcttgtccctggtaatggaatgtctcggtgtaaaaagctgacc540
attcccattcgttctattctgagataggagaaaaccgccctgtggctggaggtgagatat600
gctggcagcaatactgctctgttactccttgctacactgagatgtttgggtaaagagaaa660
cataaatctagcctacgtgcacatctgggcacagtacctttccttgaacttattcgtgat720
acagattcctttgctcacatgtttccctgctgaccttcttcccacctgttgccctgctac780
actcccctcgctaagacagtaaaaataatgatcaataaatactgagggaactcagaggcc840
agcgccggtgcgggtcctccacatgctgagcgccggtcctgggcccactgttctttctct900
atactttgtctctgtgtcttatttcttttctcaaa935
<210>12
<211>3184
<212>dna
<213>智人
<400>12
gtcaggcctctgagcccaggccaggccatcgcatcccctgtgacttgcacgcatacatcc60
agatggcctgaagtaactgaagatccacaaaagaagtaaaaacagccttaactgatgaca120
ttccaccattgtgatttgttcctgccccaccctagctgatcaatgtactttgtaatctcc180
cccacccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagat240
ccacccctgcccagcagagaacaaccccctttgactgtaattttccattaccttcccaaa300
tcctataaaacggccccacccctatctcccttccctgactctcttttcggacgcagcccg360
cctgcgcccaggtgaaatacacagccatgttgctcacacaaagcctgtttggtgggctct420
tcacacggacacgtatgcaatttggtgccgtgactcggatcgggggacctcccttgggag480
atcaatcccctgtcctcctgctctttgctccgtgggaaagatccacctatgacctcaggt540
cctcagaccgaccagcccaagaaacatctcaccaatttcaaatccggtaagcggcctctt600
tttactctcttctccaacctccctcactatacccttagcggcaagtcccgctttcctggg660
gcaggggcaggtacccctcaaccccttctccttcaccctcagcggcaagtcccgctttcc720
tggggcaggggcaggtgcccctcgaccccttctccttcaccctcagcggcaagtcccgct780
ttcctggggcaggggcaggtgcccctcaaccccttctccttcaccctcagcggcaagtcc840
cgctttcctggggcaggggcaggtgcccctcgaccccttctccttcaccctcagcggcaa900
gtcccgctttcctggggcaggggcaggtacccctcgaccctttctccttcaccctcagcg960
gcaagtcccgctttcctggggcaggacttgccgctttcctggggtagggacaagtacccc1020
tgaaccccttctccacattacctgcttttcaagggcctgtttcccttgcctccataactg1080
ttgtgggtattgacagccaggcttctaaacctcttaaaactcccccactctggtgccaac1140
ttggacgacactcttttatgcactcttttttagttatccccacctgcccagttcccttat1200
taggccgagatattttaaccaaattatctgcttccctgactattcctggactacagctgc1260
aactcattgctgcccttctcgctaacccaaagcctccttcgcgtctttctttcatatccc1320
cccaccttaacccacaagtatgggacatctctactccttccctggcaactgatcacatgc1380
ccattaccatcccgttaaaacctaatcacccttaccccactcaacgccagtatcccatcc1440
cacagcatgctttaaaaggattaaagcctgttatcactcgcctgctacagcatgggcttc1500
taaaacctataaactctccttaccattcccccattttacctgtcctaaaaccagacaggg1560
cttacaggttagttcagaatctgtgccttatcaaccaaattgttttgcctatccaccccg1620
tggtgccaaacccatatactctcctatcctcaatacctgcctctacaacccattattctg1680
ttctggatctcaaacatgctttctttactattcctttgcacccttcatcccagcctctct1740
ttgctttcacttggactgaccctgacacccattaggctcagcaaattacctaggctgtac1800
tgccgcaaggcttcacagacagcccccattacttcaatcaagcccaaatttcttcctcat1860
ctgttacctatctcggcataattctcataaaaacacacgtgctctccctgccaatcgtgt1920
ccgactgatctctcaaaccccggcacctttctacaaaacaataactcctttccttcctag1980
gcatggttagcgtggtcgtaattcttacacaagagccaggaccacaccctgtagcctttc2040
tgtccaaacaacttgaccttactgttttaacctagccctcatgtctgcgtgcagcggctg2100
ccgctgctttaatacttttagaggccctcaaaatcacaaactttatcagtcctccaggcc2160
caagttgactcttcagctgcagttgtcctccaaaaccgccaaggccttgactgacttact2220
gctgaaaaaggaggactctgcatattcttaaatgaggagtgttgtttttacctaaatgca2280
tctggcctggtgtatgacaacataaaaaaactcaaggatagagcccaaaaacttgccaac2340
caagcaagtaattacgctgaacccccttgggcactctctaattggatgtcctgggtcctc2400
ccaattcttagtcctttaatacccatttttctcctccttttattcggaccttgtatcttc2460
cgtttagcttctcaattcatccaaaaccgtatccaggccatcaccaatcattctatacga2520
caaatgtttcttctaacatccccacaatatcaccccttaccacaagacctcccttcagct2580
taatctctcccactctaggttcccacgccgcccctaatcccgctcgaagcagccctgaga2640
aacatcacccgttctctctccataccaccccccaaaaatttccgccgctccaacacttca2700
acgctattttgttttatttgtcttattaatataagaaggcaggaatgtcaggcctctgag2760
cccaggccaggccatcacatcccgtgacttgcacgcatacatccagatggcctgaagtaa2820
ctgaagatccacaaaagaagtaaaaacagccttaactgatgacattccaccattgtgatt2880
tgttcctgccccaccctaactgatcaatgtactttgtaatctcccccacccttaagaagg2940
ttctttgtaattctccccacccttgagaatgtactttgtgagatccacccctgcccagca3000
gagaacaaccccctttgactgtaattttccattaccttcccaaatcctataaaacggccc3060
aacccctatctcccttccctgactctcttttcggacgcagcccgcctgcgcccaggtgaa3120
ataaacagccatgttgctcacacaaagcctgtttggtgggctcttcacacggacgcgcat3180
gaaa3184
<210>13
<211>5641
<212>dna
<213>智人
<400>13
tcaggcctctgagcccaagccaagccatcacatgccctgtgacttacatgtatatgccca60
gatggcctgaagtaactgaagaatcacaaacaaagtgaatatgccctgccccaccttaac120
tgatgacattccaccacaaaagaagtgtaaatggccagtccttgccttaagtgaggacat180
taccttgtgaaagtccttttcctagctcaccctggctcaaaaagcacccccactgagcac240
cttgagacccccactcctgcccaccagagaacaaaccccctttgactgtaattttccttt300
acctacccaaatcctataaaacggccccacccttatctcccttcgctgactctcttttcg360
gactcagcccacctgcacccaggtgaaataaacagctttactgctcacacaaagcctgtt420
tggtggtctcttcacacggacgcgcatgaaatttggtgccatgactcggatcaggggacc480
tcccttgggagatcaatcccccgtcctcttgttctttgctccatgagaaagatccaccta540
tgacctcaggtcctcagaccgaccagcccaagaaacatctcaccaatttcaaatccggta600
agtggcctctttttactctcttctccaacctccctcactatccctcaacctctttctcct660
ttcaatcttggtgccacacttcaatctctcccttctcttaatttcaattcctttcaattc720
ctttggtagagacaaaggagacgcattttatccgtggacccaaaactccggcgccggtca780
cggactgggaaggcagccttcccttggtgtttaatctttgcagggacgcctgcctcggtc840
cttcacccttagcggcaagtcctgctttcctggggcaggggcaagtacccctcaacccct900
tcttcaccctcagcggcaagtcctgctttcctggggcaggggcaagtacccctcaacccc960
ttctccttcaccctcagcggcaagtcccgctttcctagggggcaagaaccccccaatcgc1020
ttatttccacaccccaacctcttatctctgcgccccaatcccttatttccgtgccccaac1080
cccttctctgcttttctggagggcaagaaccccccacccctactccatgtctctactctt1140
ttgtctgggcttgcctccttcactatgggcaagcttccaccttccattcctccttcttct1200
cccttagcctgtgttctcaaaaacttaaaacctcttcaactcacacctgacctaaaacct1260
aaatgccttattttcttctgcaatgccacttgaccccaatacaaactcgacagtagttcc1320
aaatagccagaaaatggcactttcaatttttccatcctgcaagatctaaataattcttgt1380
cgtaaaatgggcaaatgttctgaggtgcctgacgtccaggcattcttttacacatctgtc1440
ccttcctagtctctgtgcccagtgcaactcgtcccaaatcttccttctttccctcccgcc1500
tgtcccctcagtcccaaccccaagcgtcgctgagtctttctaatcttccttttctacaga1560
cccatctgacctctcctctcctcgccagctcaagctaagtcccaattcttcctcagcctc1620
cgctcctgcaccctgtaatctttttatcgcctcccctcctcacacctggtctggcttaca1680
gtttcattccgtgactagccctcccccacctgcccagcaatttacccttaaaaaggtggc1740
tggagccaaaggcatagtcaagtttaacgctcctttttctttatcccaaatcagatagcg1800
tttaggctctttttcatcaaatataaaaacccagcccagttcatggctagtttggcagca1860
accctgagaggctttacagccctaaaccctaaaaggtcaaaaggccgtcttattctcaat1920
atacattttattacccaatctgctcccgacattaaataaaactccaaaaattaaattccg1980
gccctcaaaccccacacaggatttaatgaacctcgccttcaaggtgtacaataatagaaa2040
aaagttgcaattccttgcctccactgtgagacaaaccccagccacatctccagcacacaa2100
gaacttccaaacgcctgaaccgcagcggccaggcgttcctccagaacctcctccaggagc2160
ttgctacaagtgccagaaatctgaccaccaggccaaggaatgcccgcagcccaggattcc2220
tcctaagccatgtcccatctgtgcaggaccccactggaaatcggactgttcaactcacct2280
ggcagccactcccagcgcccctggaactctggcccaaggttctctgactgactccttctc2340
ggcttagcggctgaagactgatgctgcccgatcacctcagaagccccctagaccatcacg2400
gacgccgagcttcaagtaactctcacagtggagggaagtccgtccccttctttatcaata2460
cggaggctacccactccacattaccttcttttcaagggcctgtttccctcgcctccataa2520
ctgttgtgggtattgatgaccaggcttctaaacctcttaaaactccccaactctggtgcc2580
aacatagacaatactcttttaagcactcctttttagttatccccacctgcccagttccct2640
tattaggccaaaacactttaactaaattatctgcttccatgactattcctagactacagc2700
tatatctcattgctgcccttcttcccaatccaaagcctcctttgcgtcctcctcttgtat2760
cccccccaccttaacccacaagtataagatacctctactccctccttggtgagactgatc2820
acgcaccccttaccatctcattaaaacctaatcacccttaccccgctcaacgccaatatc2880
ccatcccgcagcacgctttaaaaagattaaagcttgttatcactcgcctgctacagcatg2940
gccttttaaagcctataaattctccttacaattcccccattttacctgtcctaaaaccag3000
acaagccttacaagttagttcaggatctgcaccttatcaaccaaattgttttgcctatcc3060
accccatggtgccaaacccatatactctccaatcctcaatacctgcctctactacccatt3120
attctgttctggatctcaaacatgctttctttactattgctttgcacccttcatcccagc3180
ctctctttgctttcacttggactgaccctgacacccatcaagctcagcaaattacctagg3240
ctgtactgccgcagagcttcacagacagcccccattacttcagtcaagcccaaatttctt3300
cctcatctgttacctatctcggcataattctcataaaagcacacgtgctctccctgccaa3360
tcgtgttcgactgatctctcaaacccaagcatcttctacaaaacaacaactcctttcctt3420
cctaggcatggttagcgcggtcagaattcttacacaagagccaggaccacaccctgtagc3480
ctttctgtccgaacaacttgaccttactgttttagcctagccctcatgtctgcgtgcagc3540
ggctgctgctgctttaatacttttagaggccctcaaaaatcacaaactatgctcaactca3600
ctctctacagttctcataacttccaaaatctattttcttcctcatacctgacgcaaatac3660
tttctgcttcccggctccttcagctgtactcactctttgttgagtctcccacaattaccg3720
ttgttcctggcccagacttcaatctggcctcccacattattcctgataccacacctgacc3780
cccatgactatctctctgatccacctgacattcaccccatttccccaaatttccttcttt3840
cctgttcctcacgctgatcacgcttgatttattgatggcggttccaccaggcctaatcgc3900
cacacaccagcaaaggcaggttatgctatagtacaagccactagcccgcctcttagaacc3960
tctcatttcctttccatcgtggaaatctatcctcaaggaaataacttctcagtgttccat4020
ctgctattctactactcctcagggattattcaggccccctcccttccctgcacatcaagc4080
tcgaggatttgccccacccaggactggcaaattagctttactcaacatgccctgagtcag4140
ataactaaaatatctcttagtctaggtagatactttcactggataggtagaggcctttcc4200
tacagggtctgggaaggccaccgcagtcatttcttcccttctgtcagacataattcctca4260
gtttagccttcccacctcaatacagtctgacaacagatgagcctttattagtcaaatcag4320
ccaagcaggttttcaggctcttagtattcagtgaaacctttacatcccttacggtcctcc4380
gtcttcaagaaaagtagaatggactaaaggtcttttaaaaacacacctcaccaagctcag4440
ccaccaacttaaaaaggactggacaatacttttaccactttcccttctcagaattcaggc4500
ctgtcctcagaatgctacagggtacagcccatttaagctcctgtatagatgctccttttt4560
attaggccccagcctcattccagacaccagaccaacttagactgtgccccaaaaaacttg4620
tcatccctactatcttctgtctagtcatactcctgttcaccgttctcaactactcataca4680
tgccctgttcttgtttacactgccggtttacactgtttttccaagccatcacagctgata4740
tctcctggtgctatccccaaactgccactcttaactcttgaagtaaataaataatctctg4800
ctggcaggactatgctgaatctccttaggcactctctaatcagatatcctgagtcatccc4860
aattcttagaccttttatatctgttttactccttctcttattccatttagtttctcaatt4920
catccaaaaccatatccaggccatcaccagtcattctatatgacaaatgtttcttctaac4980
atccccacaatctcaccccttaccacaagacctcccttcagcttaatctctcccactcta5040
ggttcccacgcctcccctaatcccgcttgaagcagccctgagaaacatcacccattctct5100
ctccataccaccccccaaaaatttccgccgctccaacacttcaacactattgtgttttat5160
ttttcttattaatataagaagtcaggaatatcaggcctctgagcccaagccaagccatcg5220
catcccctgtgacttgcacgtatatgcccagatggcctgaagtaactgaagaatcacaaa5280
agaagtgaatatgccctgccccaccttaactgatgacattccaccacaaaagaagtgtaa5340
atgcccgggtcttgccttaagtgatgaccttaccttgtgaaagtccttttcctagctcat5400
cctggctcaaaaatcacccccactgagcaccttgagacccccactcctgcccgccagaga5460
acaaacccccttggactgtaattttcctttacctacccaaatcctataaaagggctccac5520
ccttatctcccttcactgactctcttttcggactcagcccacctgcacccaggtgaaata5580
aacagctttactgctcacacaaagcctgtttggtggtctcttcacacggacgcgcatgaa5640
a5641
<210>17
<211>5710
<212>dna
<213>智人
<400>17
gtcaggcctctgagcccaagccaagccatcgcatcccctgtgacttgcacgtatgccccc60
agatggcctgaagtaactgaagaatcacaaaagaagtaaaaaggccctgccccaccttaa120
ctgatgacattccaccattgtgatttgttcctgccccaccttaactgagtgattaaccct180
gtgaatttccttctcctggctcagaagctcccccactgagcaccttgtgaccccccgccc240
ctgcccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatcctat300
aaaacggccccacccctatctcccttcgctgactctctttttggactcagcccacctgca360
cccaggtgaaacaaccagccatgttgctcacacaaagcctgtttggtggtctcttcacac420
agacgcgcatgaaatttggtggatcaggggacctcccttgggagatcaatcccctgtcct480
cctgctctttgctccatgagaaagctccacctaccacctcaggtcctcagactgaccagc540
ccaagaaacatctcaccaatttcaaatccggtaagtggcctctttttactctcttctcca600
acctccctcactatccctcaacctctttctcctttcaatcttggtgccacacttcaatct660
ctcccttctcttaatttcaattcctttcattttctggtagagacaaagaagacacgtttt720
atccgtggacccaaaactccagcactggtcatggactgggaagacagacttcccttggtg780
tttaatcattgcagagacacctctctgattattcacccacatttcaaaggtgtcagacca840
catagggaggcctgccttggtcctccacccttagcggcaagtcccgcttttctgggggag900
gggcaagtatcccaaccccttctctccatgtctctaccccttctctgcttttctggggga960
ggggcaagtacccctcaaccccttctccttcacccttagcggcaagtcctgcttttctgg1020
gggaggggcaagtaccccaaccccttcttcagtgtctctaccccttctctgcttttctgg1080
gggaggggcaagtacccctcaaccccttctccttcacctttagtggcaagtcccgctttt1140
ctagggggcaagaacccccaatcccttatttctgtaccccaacctcttatctctgtgccc1200
caatcccttatttccatgccccacccccccttcccacttttctggagggtaagaaccccc1260
aaaacccttccctccgtgtctctacaccctcttttctctgggtttgcctccttcactatg1320
ggcaaccttccatcctccattcctccttcttctcccttagcctgtgttctcaagaactta1380
aaacctcttcaactcacacctgacctaaaacctaaatgccttattttcttctgcaatgac1440
gcttaaccccaatacaaactcgacatagttccaaatagccagaaaacggcactttcaatt1500
tttccatcctacaagatctaaataattcttgtcgtaaaatgggcaaatggcctgaggtgc1560
ctgacgtccaggcattcttttacacatcagtcccttcctagtctctgtgcccagtgcaac1620
tcatcccaaatcttccttctttccctcccgcctgtcccctcagtcccaaccccaagcatc1680
gctgagtctttctaatcttccttttctacagacccatctgacctctcccctcctcgccag1740
gccgagctaggtcccaattcttcctcagcctccgctcctctaccctataatctttttatc1800
gcctcccctcctcacacctggtccggcttacagtttcgttccgtgactagccctccccca1860
cctgcccagcaatttattcttaaaaaggtggctggagccaaaggcatagtcaaggttaat1920
gctcctttttctttatcccaaatcagaagcgtttaggctgtttttcatcaaatataaaaa1980
tccagcccagttcacggctcgtttggcagcaaccctgagacgctttacagccctagaccc2040
taaaaggtcaaaaggccatcttattctcaatatacattttactacccaatctgctctgga2100
cattaaactccaaaaattagaatctggcccccaaaccccacaacagggcttaaataacct2160
caccttcaaggtgtacaataatagaaaaaagttgcaattccttgcctccactgtgagaca2220
aaccccagccacatctccagcacacaagaacttccaaacgcctgaaccgcagcggccagg2280
cgttcctccagaacctcctcccccaggagcttgctacatgtgccggaaatctggccactg2340
ggccaaggaatgcccgcagcctgggattcctcctaagccatgtcccatctgtgtgggacc2400
ccactgaaaatcggactgttcaactcacctggcagccactcccagagcccctggaactct2460
ggcccaaggctctctgactgactccttcccagatcttctcagcttagcggctgaagactg2520
acactgcctgatcgcctcggaagccccctagaccatcaaggacgccgagcttcaggtaac2580
tctcacagtggaaggtaagcccatccccttcttaatcaatacggaggctacccactccac2640
attaccttcttttcaatggcctgtttcccttgcctccataactgttgtgggtattgatgg2700
ccaggcttctaaacctcttaaaactccccagctctggtgccaacttagataatactcttt2760
taagcattcctttttagttatccccacctgccctgttcccttattaggctgagacacttt2820
aactaaattatctgcttccctgactattcctggactacagctatatctcattgccgccct2880
tctccccaatccaaagcctcctttgcgtcctcctcttgtattcccccaccttaaccctca2940
agtataagatacctctactccctccttggcgaccgatcatgcaccccttaccatctcatt3000
aaaacctaatcacccttaccctgctcaatgtcaggatcccatcccacagcatgctttaaa3060
aggattaaagcctgttatcactcacctgctatagcatggccttttaaagcctataaactc3120
tccttacaattcccccattttacctgtctaaaaccagacaagccttacaagttagttcag3180
gatctgcgccttatcaaccaaattgttttgcctatccaccccatggtgccaaacccatat3240
actctcctatcctcaatacctccctctactacccattattctgttctggatctcaaacat3300
gcttttttttactattcctttgcacccttcatcccagcctctctttgctttcacttagac3360
tgaccctgacaccagttaggctcagcaaattacctgggctgtactgctgcaaggcttcac3420
agacagcccccattacttcaatcaagccaaaatttcatcctcatctgttacctatctcag3480
cataattctcataaaaacacatgtgctctccctgctgatcgtgtccgattaatctcccaa3540
acctcaatcccttacaaagcaactcctttccttcctaggcatggttagcgcggtcagaat3600
tcttacacaagagccaggaccgcaccctgtagcctttctgtccaaacaacttgaccttac3660
tgttttagcctagccctcatgtctgcgtggagcggctgccgctgctttaatattttttga3720
ggccctaaaaatcacaaactatactcaactcactctctacatttctcataacttccaaaa3780
tctattttcttcctcatacctgacgcatgtactttctgctccccggctccttcagctgta3840
ctcactctttgttaagtcccacaattaccattgttcctggcccggacttcaatctggcct3900
cccgcattattcctgataccacacctgacccccatgactgtatctctctgatccacctga3960
cattcaccccatttccccatatttccttctttcctgttcctcaccctgatcacgcttgat4020
ttattgatggcagttccaccaggcctaatcgccacacaccagcaaaggcaggctatgcta4080
tagtacaagccactagcccgcctcttaaaacctctcattttctttccatcatagaaatct4140
atcctcaaggaaataacttctcagtgttccatctgctattctactactcctgaaggatta4200
ttcaggccccctcccttccctacacatcaagctcgaggatttgcccccgcccagtactgg4260
caaattagctttactcaacatgccccgagtcacaaaaactaaaatacctcttagtctaag4320
tagacactttcactagataagtagaggcctttcctacagggtctgagaaggccaccacag4380
tcatttcttcccttctgtcagacataattcctcagtttagccttcccacctctatacagt4440
ctgataacagaccagcctttattagtcaaatcagccaagcattttttcaggctcttagta4500
ttcagtgacagactaatggtctattaaaaacacacttcaccaagctcagccaccaactta4560
aaaaggactggacaatacttttaccactttcccttctcagaagtcagacctgtcctcaga4620
atcctacaaggtacagcccatttaagctcctgtatatacgctcctttttattaggcccca4680
gtctcattccagacaccagaccaacttagactgtgccccaaaaaacttgtcatccctact4740
atcttctgtctagtcatactcctattctccgttctcaactactcatacatgccctgctct4800
tgtttacactgccagtttacactgtttctccaagccatcacagctgatatctccttgtgc4860
tatccccaaactgccactcttaactcttgaagtaaataaataatctttgctggcaggact4920
atgctgaatctccttaggcactctaatcagatgtcctaggtcctcccaattcttagacct4980
tttccatttagtttttcaattcatacaaaacatatccaggccatcaccaatcattctaca5040
cgacaaatgtttcttctaacaaccccacaatatcaccccttaccacaagatcttccattc5100
agcttaatctctcccactctaggttcccacgccgcccctaatcccgcttgaagcagccct5160
gagaaacatcgcccattctctctccataccaccccccaaaaatttttgccgccccaacac5220
ttcaacactattttgttttatttttcttattaatataagaaggcaggaatgtctggcctc5280
tgagcccaagccaagccatcacgtcccctgtgacttgcacctatatgcccagatggcctg5340
aagtaactgaagaatcacaaaagaagtgaaaaggccctgccccgccttaactgatgacat5400
tccaccattgtgatttgttcctgccccaccttaactgagtgattaaccctgtgaatttct5460
ttctcctggctcagaagctcccccactgagcaccttgtgacccccccccacctcccctgc5520
ccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatcctataaaa5580
cggccccacccccatctcccttcgctgactctcttttcggactcagcccacctgcaccca5640
ggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacatggac5700
gcgcatgaaa5710
<210>19
<211>2187
<212>dna
<213>智人
<400>19
tgcggtcagaattcttacacaagagccaggaccgcaccctgtagcctttctgtccaaaca60
acttgaccttactgttttagcctagccctcatgtctgagtgcagcgtctgccgctgcttt120
aatactgttagaggccctaaaaatcacaaactatgctcaactcacgctctacatttctca180
taacttccaaaatctattttcttcctcatacctaacgcatatactttctgctccctggct240
ccttcagctgtactcactctttaagtcccacaattaccattgttcctggcccggacttca300
atctggcctctcacattattcctgataccacacctgacccccatgactgtatctctctga360
tccacctgatattcaccccatttccccatatttccttctttcctgttcctcaccctgatc420
acgcttgatttattgatggcagttccaccaggcctaattgccacacaccagcaaaagcag480
gctatgctatagtacaagccactagcccgcctctcagaacctctcatttcctttccatcc540
tggaaatctatcctcaaggaaataacttcacagtgttccatctgctattctactactcct600
cagggattattcaggccccctcccttccctacacatcaagctcgaggatttgcccccacc660
caggactggcaaattagctttactcaacatgcccaagtcaggaaactaaaatacctctta720
gtctaaatagacactttcactgaataagtaaaggcctttcctacagggtctgagaaggcc780
accgcagtcatttcttcccttctgtcagacataattcctcagtttagccttcccacctct840
atacagtctgataacagaccagcctttattagtcaaatcagccaagcagtttttcaggct900
cttagtattcagtgaaacctttatatcccttacggtcctccgtcttcaagaaaagtagaa960
cggactaaaggtcttttaaaaacacacctcaccaagctcagccaccaacttaaaaaggac1020
tggacaatacttttaccactttcgcttctcagaattcaggcctgtcctcagaatgttaca1080
aggtacagcccatttaagctcctgtatagacagacgctcctttttattaggccccagtct1140
catttgacaccagaccaacttagactgtgccccaaaaaaacttgtcatccctactatctt1200
ttgtctagtcatactcctattcaccattctcaactactcatacctgccctgctcttgttt1260
acactgccggtttacactgtttctccaagccatcacagctgatatctcctggtgctatcc1320
ccaaacccccactctaaactcttgaagtaaataaataatctttgctggcaggactatgct1380
gaatctccttaggcactctctaatcagatgtcctaggacctcccaattcttagacctttt1440
atacctgtttttctccttctcttattacatttagtttttcaattcatacaaaaccgtatc1500
caggccatcaccaataattctaaatgacaaatgtttcttctaacaaccccacaatatcac1560
cccttaccacaagatcttccttcagcttaatctctcccacactaggttcccacaccgccc1620
ctaatcccgcttgaagcagccctgagaaacattgcccattctctctccataccaccccca1680
aaaattttcgctgccccaacacttcaacactattttgtttcatttttcttattaatataa1740
gaaggcaggaatgtcaggcctctgagcccaagccaagccatcacatcaactgtgacttgc1800
acatatacgcccagatggcctgaagtaactgaagaatcacaaaagaagtgaaaaggccct1860
gccccgccttaactgatgacattccaccattgtgatttgttcctgccccaccttaactga1920
gtgattaaccctgtgaatttccttctcctggctcagatgctcccccactgagcaccttgt1980
gacccccgcccctgcccaccagagaacaacccccctttgactgtaattttccattacctt2040
cccaaatcctataaaacggccccacccttatctcccttcactgactctcttttcggactc2100
agcccgcctgcacccaggtgaaataaaacagccatgttgctcccacaaagcctgtttggt2160
ggtctcttcacacggatgcacatgaaa2187
<210>22
<211>5854
<212>dna
<213>智人
<400>22
gtcaggcctctgagcccaagccaagccatcgcatcccctgtgacttgcacatatacgccc60
agatggcctgaagtaactgaagaagcacaaaagaagtgaaaaggccctgtcccgccttaa120
ctgatgacattccaccattatgatttgttcctgccccaccttaactgagtgattaaccct180
gtgaatttccttctcctggctcagaagctcccccactgagcaccttgtgacccctgcccc240
tgcccaccagagaacaaccccctttgactgtaattttccattaccttcccaaatcctatg300
aaacggccccattcctatctcccttcactgactctcttttcggactcagcccgcctgcac360
cgaggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacacg420
gacttgagtgaatttggtgctgtgactcggactgggggacctccgttgggagatcaatcc480
cccgtcctcctgctctttactccatgagaaagatccacctatgacctcaggtcctcagac540
caaccagcccaagaaacatctcaccaatttcaaatccagtaagtggcctctttttactct600
cttctccatcttccctcactatccctcaacctctttctcccttcaatcttggggtcacac660
ttcaatctctcccttctcttaatttcaattcctttcattttctggtagagacaaaggaga720
cacgttttatccatggacccaaaactccggcgccggtcacggactgggaaggcagacttc780
ccttggtgtttaatcattgcagggacacctctctgattattcacccacatttcaaaggtg840
tcagaccacacagggatgcctgccttggtccttcacccttcgcggcaagtcctgcttttc900
tgggggaggggcaagtacccctcaaccccttctccttcacccttagcggcaagtcccgct960
tttctggaggaggggcaagtaccccaaccccttctctccgtgtctctaccccttctctga1020
ttttctggggcaagggcaagaacccctcaaccccttctccttcccctcagtggcaagtcc1080
cgcttttctaggggaggggcaagtaccccaaccccttctctccgtgtctctaccccttct1140
ctgcttttctggaggagaggcaagtaccccaacctcatatctctgcaccccgatccctta1200
tttccacaccctgacctcgtatctctgcgccctgaccccttctctgcttttctggaggac1260
aagaaacccccaccccttctctgtgtctctactcttttctctgggcttgcctccttcact1320
atgggcaagcttccaccttccattcctccttctcccttagcctgtgttcttaagaactta1380
aaacgtcttcaactgtcacctcacctaaaatctaagtgtcttattttcttctgcaatgcc1440
gcttgaccccaatacaaactcgacagtagttccaaatagccggaaaacagcactttcaat1500
ttttccatcctacaagatctaaataattcttgttgtaaaatgggcaaatggtctgaggtg1560
gctgacatccaggcattctttcacacatcagtcccttcctagtctctgtgcccagtgcaa1620
ctcatcccaaatcttccttctttccctcccgcctgtcccctcagtcccaaccccaagcgt1680
cgctgagtctttctaatcttccttttctacagacccatctgacctctcccctcctcacca1740
ggccaagctaggtcccgattcttcctcagcctccgctcctccaccctataatctttttat1800
cgcctcccctcctcacacctggtccagcttacaatttcgttccatgagtatccctccccc1860
acctgcccagcaatttactcttaaaaacgtggctggagccaaaggcatagtcaaggttaa1920
tgctcctttttctttattccaaatcagaagcgtttaggctctttttcatcaaatataaaa1980
acccagcccagttcatggctcattcggcagcaaccctgagacgctttacagccctagacc2040
ctaaaaggtcaaaaggccatcttattctcaatatatattttattacccaatccgctcccg2100
acattaaataaaactcccaaagttggaatctggccctcaaaccccacaacaggacttaat2160
taacctcaccttcaaggtgtacaataataaaaaaaaagttgcaattccttgcctctactg2220
tgagacaaaccccagccacatctccagcacacaagaacttccaaacgcctgaaccgcagc2280
agccaggcgttcctccagaacctcctcccccaggagcttgctacaagtgccagaaatctg2340
accaccaggccaaggaatgcctgcagcccaggattcctcctaagccgtgtcccatctgtg2400
cgggaccccactggaaatcggactgttcaactcacctggcagccactcccagagcccctg2460
gaactctggcccaaggctctctgactgactccttctcggcttagcagctgaagactgaca2520
ctgcccgaccacctcgaaagccccgtagaccatcacagacgccgagcttcaagtaactct2580
cacagtgcaaggtaagtccgtccccttaatcaatatggaggctacccactccacattacc2640
ttcttttcaaggtcctgtttcccttgcctccgtaactgttgtaggtattgacggccaggc2700
ttctaaacctcttaaaactccccaactctggtgccaacttagacaatactcttttaagca2760
ctccttttagttatccccacctgcccagttcccttattaggccgagacactttaaattat2820
ctgcttccctgactattcctggattacagctgcatctcattgccgcccttcttcccaatc2880
caaagcctcctttgcatcctcctcttgtattcccccaccttaacccacaagtataagata2940
cctctactccctccttggcgactgatcatgcaccccttaccatctccttaaaacctaatc3000
acccttaccccactcaatgccaatatcccatcccacagcatgctttgaaaggattaaagc3060
ctgttatcactcgcctgctacagcatggccttttaaagcctataaactctccttacaatt3120
cccccattttacctgtcctaaaaccagacaagccttacaagttagttcaggatctatgcc3180
ttatcaaccaaattgttttgcctatccaccctatggtgccaaacccatatactctcctat3240
cctcgatacctccctccacaatccattattctgttctggatctcaaaaatgctttcttta3300
ctattcctttgcacccatcatcccagcctctctttgctttcacttggactgaccctaaca3360
cccattaggctcagcaaattacctgggctgtactgccccaaggcctcacagacagccccc3420
attacttcagtcaagcccaaatttcatcctcatctgttacctatctcagcataattattc3480
ataaaaacacaggtgttctccctgttgattgtgtccgattaatctcccaaacctcaattc3540
cttacaaaacaacaactcctttccttcctaggcatggttaatgtggtcagaattcttaca3600
caagagccaggaccgcaccctatagcctttctgtccaaacaacttgaccttactgtttta3660
gcctagccctcatgtctgcgtgcagcggctgccgctgctttaatacttttagaggcccta3720
aaaatcacaaactatgctcaactcactctctacatttctcataacttccaaaatctattt3780
tcttcctcatacctgatgcatatactttctgctccccggctccttcagctgtactcactc3840
tttgttaagtcccacaattaccattgttcctggcccggacttcaatctggcctcccacat3900
tattcctgataccacacctgacccccatgactgtatctctctgatccacctgacattcac3960
cgcatttccccgtatttccttctttcctgttcctcaccctgatcacgcttgatttattga4020
tggcagttccaccaggcctaattgccacacaccagcaaaggcaggctatgctatagtaca4080
agccactagcccacctcttagaacctctcatttcctttccattgtagaaatctatcctca4140
aggaaataacttctcagtgttccatctgctattctactactcctcaaggattattcaggc4200
cccctcccttccctacacatcaagcccggggatttgcccctgcccaggactagcaaattt4260
gctattctactactcctcaaggattattcaggccccctcccttccctacacatcaagttc4320
aaggatttgcccctgcccaggactgtcatattagctttactcaacatgccccgagtcaca4380
aaacctaaaatacctcttagtctaagtagacgctttcactagataggtagagacctttcc4440
tacagggtctgaggccaccgcagtcatttcttcccttctgtcagacataattcctcagtt4500
tagccttcccacctctatacagtctgataacagaccagtctttattagtcaaatcagcca4560
agcagtttttcaggctcttaatattcagtgaaacctttatatcccttatagtcctctgtc4620
tttaagaaaagtagaacagactaaaggtcttttaaaaacacacctcaccaagctcagcca4680
ccaacttaaaaagaactggacaatacttttaccactttcccttctcagaagtcagacctg4740
tcctcagaatgctacaaggtacagcccatttaagttcctgtatagatgctcctttttatt4800
aggccccagtctcattccagacactggatcaacttagactgtgcccccaaaaaaacttgt4860
catccctactattttctgtctagtcatactcctattctccattctcaactactcatacat4920
gccctgctcttgtttacactgccagtttacactgtttctccaagccatcacagctgatat4980
ctcctcgtgctatccccaaaccgccactcttaactcttgaagtaaataaataatctttgc5040
tggcaggactatgctgaatctccttaggcactctctaatcagatgtcctaggtcctccca5100
attcttggaccttttatacctgtttttctccttctcttattccatttagtttttcaattc5160
atacaaaactgtatccaggccatcaccaataattcgaaatgacaaatgtttcttctaaca5220
accccacaatatcacccctttctacaaaatcttccttcagcttaatctctcccactctag5280
gttcccacgctgccccaatcccacttgaagcagccctgagaaacatcgtccattctctct5340
ccataccaacccccaaaaattttcgccaccccaagacttcaacactattttatttttctt5400
attaatataagaaggcaggaatgtcaggcctctgagcccaagccaagccatcgcatcccc5460
tgtgacttgcacatatacacccagatggcctgaagtaactgaagaatcataaaagaagtg5520
aaaaggccctgccccgccttaactgatgatattccaccattgtgatttgttcctgcccca5580
ccttaactgagtgattaaccctgtgaatttccttctcctggctcagaagctcccccactg5640
agcaccttgtgacccctgcccctgcccaccagagaacaaccccctttgactgtaattttc5700
cattaccttcccaaatcctataaaacggccccacccctatctcccttcacttgactcttt5760
tcggactcagtccacctgcaccgaggtgaaataaacagccatgttgctcacacaaagcct5820
gtttggtggtctcttcacacggactcgagtgaaa5854
<210>24
<211>5644
<212>dna
<213>智人
<400>24
gtcaggcctctgagcccaagccaagccatcacatcccctgtgacttgcacgtatacaccc60
agatggcctgaagtaactggagaatcacaaaagaagtgaaaaggccctgccccgccttaa120
ctgatgacattccaccattgtgatttgttcctgccccaccttaactgagtgattaaccct180
gtgaatttccttgtcctggctcagaggctcccccactgagcaccttgtgaccactgcccc240
tgcccaccagagaacaaccccctttggctgtaattttccattacctttccaaatcctata300
aaacggccccacccctatctcccttcgctgactctctttttggactcagcccacctgcac360
ccaggtgaaataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacatg420
gacgcacatgaaatttggtgccgtgactcagatcaggggacctcccttgggagataaatc480
ccctgtcctcctgctctttgctctgtgagaaagatccacctacgacctcaggtcctcaga540
ccgaccagcccaagaaacatctcaccaatttcaaatctggtaagtggcctctttttactc600
tcttctccagcttccctcactatccctcaacctctttctcctttcaatcttggcgccaca660
cttcaatctctcccttctcttaatttcaattcctttcattttctggtagagagagacaaa720
agagacacgttttatccatggacccaaaactccggtgctggtcacggactgggaaggcag780
ccttcccttggtgtttaatcattgcagagatgcctgattattcacccacgtttcaaaggt840
gtcagaccacgcagggacgcctgccttggtccttcacccttagcagcaagtcccgctttt900
ctggggaagaggcaagtaccccaatcccttctctccttgtctctaccccttctctgcttt960
tctgggggagggacaagtacccctcaactgcttctccttcacccttagcggcaagtcccg1020
cttttctagggggcaagaacccccaatcccttatttccacaccccaacctcttatctctg1080
tgccccaattccttatttccatgccccaaccctttctctgcttttctggagggcaagaaa1140
cccccaccccttctccgtgtctctactcttttctctggacttgcctccttcactatgggc1200
aagcttccaccttccattcctccttcttctcccttagcctatattcttaagaacttaaaa1260
cctcttcaactctcacctgacctaaaatctgagcatcttattttcttctgcaatgcgctt1320
gaccccaatacaaactcgacagtagttccaaatagccggaaaatggcactttgaattttt1380
ccatcctacaagatctaaataatccttgtcataaaatgggcaaatggtctgaggtgcctg1440
acgtccaggcattcttttacacatcagtcccttcctagtctctgtgcccagtgcaactcg1500
tcccaaatcttccttctttcccccctccgcctgtcccctcagtcccaaccccaagcgttg1560
ctgagtctttctaatcttccttttctacagacccatctgacccctcccctcctcgccagg1620
ccaagctaggtcccaattcttcctcagcctccgctcctctaccctgtaatctttttatcg1680
cctcccctcctcacacctggtccggcttacagtttctttctgtgactagccctcccccac1740
ctgcccagcaatttactcttaaaaaggtggctggagccaaaggcatagtcaaggttaatg1800
ctcctttttctttatcccaaatcagaagcgtttaggctcttttttatcaaatataaaaac1860
ccagcccagttcatggctcgttcggcagcaatcctgagacgttttacagccctagaccct1920
aaaaggtcaaaaggccatcttattctcaatatacattttattacccaatctgctcctgac1980
attaaataaaactccaaaaattagaatctggccctcaaaccccacaacaggacttaatta2040
acctcaccttcaaggtgtacaataataaaaaaaaaaattgcaattccttgcctccactgt2100
gagacaaaccccagccacatctccagcacacaagaacttccaaacgcctgaaccgcagcg2160
gccaggcgttcctccagaacctcctcccccaggagcttgctacaagtgccagaaatctga2220
ccaccaggccaaggaatgcctgcagcccaggattcctcctaagccatgtcccatctgtgc2280
gggaccacactggaaatcggactgttcaactcacctggcagccactcccagagcccctgg2340
aactctggcccaaggctctctgactgactccttcttggcttagcggctgaagattgatgc2400
tgcctcattgcctcagaagccccatagaccatcacggacgccaagcttccggtaactctc2460
acagtggagggtaagtccgtccccttcttaatcaatacagaggctacccactccacatta2520
ccttcttttcaagggcctgtttcccttgcctccataactgttgtgggtattgacgccagg2580
cttctaaacctcttaaaactccccaactctggtgctaacttagacaatactcttttatgc2640
actcttttttagttatccccacctgcccagttcccttattaggccgagatattttaacca2700
aattatctgcttccctgactattcctggatatagccacatctcattgctgcccttcttct2760
caatccaaaagcctcctttgcttcctcctcttgtattcccccaccttaacccacaagtat2820
aagatacctctactccctccttggcgaccgatcacccaccccttaccatctcattaaaac2880
ctaatcacccttaccccactcaatgccaatatcccatcccacagcaagctttaaaaggat2940
taaaacctgttatcacttgcctgctacagcatgggcttctaaaacctataaactctcctt3000
accattcccccattttacctgtcctaaaaccagacaagccttacaagttagttcagaatc3060
tgcgccttatcaaacaaattgttttgcctatccactctatggtgccaaacccatatactc3120
tcctatcctcaatacctccctctactacccattattctgttctggatctcaaacatgctt3180
tctttactattcctttgcacccttcatcccagcctctctttgtcttcacttagactgacc3240
ctgacacccattaggctcagcaaattacccgggctgtactgccgcaaggcttcacagaca3300
gcccccaatacttcagtcaagcctaaatttcatcctcatctgttacctatctcggcataa3360
ttctcataaaaacacacgtgctctccctgctgatcatgtccgattaatctcccaaacctc3420
aatcccttactaaagaacaactcctttccttcctaggcatggttagtgcggtcagaattc3480
ttacacaagagccaggaccacatcgtgtagcctttctgtccaaacaacttgaccttactg3540
ttttagcctagccctcatgtctgcgtgcagcggctgccgctgctttaatacagttagagg3600
ccctaaaaatcacaaactatgttcaactcactctctacatttctcataacttccaaaatc3660
tattttcttcctcatacctgacgcatatactttctgctccccggctccttcagctgtact3720
cactctttaagtcccacaattaccattgttcctgccccggacttcaatctggcctcccac3780
attattcctgatgccacacctgacccccatgactatctctctgatccacctgatattcac3840
cccatttccccatatttccttctttcttgttcctcaccctgatcatgcttgatttattga3900
tggcagttccaccaggcctaatcgccacacaccagcaaaggcaggctatgctatagtaca3960
agccactagcccgcctctcagaacctctcatttcctttccatcgtggaaatctatcctca4020
aggaagtaacttctcagtgttccatctgctattctactactcctcaggcattattcaggc4080
cccctcccttccctacacatcaagctcgaggatttgcccccacccaggactggcaaatta4140
gctttactcaacatgtcctgagtcaggaaactaaaatacctcttagtctaaatagacact4200
ttcactgaataagtaaaggcctttcctacagggtctgagaaggtcaccacagtcatttct4260
tcccttctgtcagacataattcctcagtttagccttcctacctctatacagtctgataac4320
agaccagcctttattagtcaaatcagccaagcagtttttcaagctcttagtattcagtga4380
aacctttatatcctttacggtcctccgtcttcaagaaaagtagaacggactaaaggtctt4440
ttaaaaacacacctcaccaagctcagccaccaacttaaaaaggactggacaatactttta4500
tcactttcacttcccagaattcaggcctgtcctcagaatgctacaaggtacagcccattt4560
aagctcctgtatagacagacgctcctttttattaggccccagtctcatttgacaccagac4620
caacttagactgtgccccaaaaaaacttgtcatccctactatcttttgtctagtcatact4680
cctattcaccattctgaactacatgccctgctcttgtttacactgccggtttacactgtt4740
tctccaagccatcacagctgatatctcctggtgctatccccaaactgccactctaaactc4800
ttgaagtaaataaataatctttgctggcaggactatgctgaatctccttaggcactctct4860
aatcagatgtcctaggtcctcccaattcttagaccttttatacctgtttttctccttctc4920
ttattccatttagttttttaattcatacaaaaccgtatccaggccatcaccaatcattct4980
atacgacaaatgttccttctaacaaccccacaatatcaccccttaccacaagatcttcct5040
tcagcttaatctctcccactctatgttcccacactgcccctaatcccgcttgaagcagcc5100
ctgagaaaaatcgcccattctctctccataccacccccaaaaattttcgccgccccaaca5160
cttcaacactattttgtttaatttttcttattaatataagaaggcaggaatgtcaggcct5220
ctgagcccaagccaagccatcacatcccctgtgacttgcacgtatacacccagatggcct5280
gaagtaactggagaatcacaaaagaagtgaaaaggccctgccccgccttaactgatgaca5340
ttccaccattgtgatttgttcctgccccaccttaactgagtgattaaccctgtgaatttc5400
cttgtcctggctcagagtctcccccactgagcaccttgtgacccccgcccctgcccacca5460
gagaacaaccccctttgactgtaattttccatttcctttccaaatcctataaaacggccc5520
cacccctatctcccttcgctgactctctttttggactcagcccacctgcacccaggtgaa5580
ataaacagccatgttgctcacacaaagcctgtttggtggtctcttcacatggacgtgcat5640
gaaa5644
<210>25
<211>5687
<212>dna
<213>智人
<400>25
gtcaggcctctgagcccaagctaagccatcatatcccctgtgacctgcacatatacattc60
agatggcctgaagcaactgaagattcacaaaagaagtgaaaatagccttaactgatgaca120
ttccaccattgtgatttgtttctgccccaccctaactgatcaatgtactttgtgatctcc180
cccacccttaagaaggttctttgtaattctccccacccttgagaatgtactttgtgagat240
ccaccccctgcccgcaaaacattgctcctaactccaccgcctaccccaaaacctataaga300
actaatgataatcccaccaccctttgctgactctcttttcggacttagcccgcctgcacc360
caggtgaaataaacagccttgttgctcacacaaagcctatttggtggtctcctcacatgg420
acgtgcatgacattgggtgctgaaacccgggacaggaggactccttcgggagaccagtcc480
ccttcccctgtcctcgccctcactccttgaggagatccacctgcaacctcgggtcctcag540
accaaccagcccaaggaacatctcatgaatttcaaattgggtaagcggtcttttcactct600
cttctccagcctctcttgctacccttcaatctccctctctcgctacccttcaatctccca660
gtccttccaactccagttctttttcctctctagtagagacaaaggaaacacattttatct720
gtagactccagcgccagtcacggacttgggaagacagtcttcccttggtgtttaatcact780
gcggggacgcctgcctgattattcactcacactccattggtgtctgatcaccgcggggac840
gcctgccttggtcattcacccacattcctttggtggcaagtcaattgcggggacacctgc900
tttggctgctcacctactcccttctccatgtctctacctttctctttaaacttacctcca960
ttactatgggcaaccttccaccctccattcccccatcttctcccttagcctgtgttctca1020
aaaacttaaaacctcttcaactctcgcctgacctaaaacctaagcgtcttattttcttct1080
gcaacaccgcttggccccaatacaaactcaataatggttctaaatagctagaaaatgaca1140
cttttgatttctccattttacaagacctggatgatttttgttgaaaaatgggcaaatggg1200
tctgatgtgcctgacatccaggcattgtttcatacactggtccctccttagtctctgctc1260
ccaatgcgactcatcccaaatctttcttctttctctgcggtctgttccttcagtctccac1320
cccaagctctgagtcctttgaatgctccttttctacagacccatctaacctctcccctcc1380
tacccaggctgctcctcaccaggctgagccaggtcccaattcttcctcagcctccgctcc1440
ccgatcctataatccttttatcacctcccctcctcacacccggtccagtttacagttaca1500
ttcctccactagccctcccccacctgcccaacaatttcctcttaaagaggtggctggagc1560
tgaaggcatagccaaggtaaatgctcctttttccgacctctcccaaatcagggtttaggc1620
tctttttcatcaaatataaaaactcaacccagttcatggcccgtttggcaacaaccctta1680
gacggtttactgccctagacccagaagggccagaaggccgtcttattctcaatatgcatt1740
ttattacccaatccactggcgacattagaaaaagctccaaaaattagattctggccctca1800
aaccccacaacgggacctaattaacctcaccttcaaggtgtacaataatagagtagaggc1860
agccaagtagcaacgtatttctgagttgcaattctttgcctccaccgtgagacaaacccc1920
agccacatctccagcacacaagaactccaaatgcctaaactgcggcggccaggcattcct1980
ccaggactgcctgccccaggatcttgcttcaagtgccagaaatctggccaccgggccaag2040
gaatgcctgcagcctgggattcctcctatgccatgtcccatctgtgcgggaccccactgg2100
aaattggactgtccaacttacccggcagccactcccagagcccctggaactctggcccaa2160
ggctctctgactgattccttcccagatcttcttgacttagcagctgaagactgatgctgc2220
ccgattgccttggaagcccccctagaccatcacagatgccgagcttcgggaactctcaca2280
gtggagggtaagtccgaccccttcttagtcaatatggaggctactcactccacattacct2340
tcttttcaagggcctatttcctttgcctccataactgttgtgggtattgatggccaggct2400
tctagaccccttaaaactccccaactctgatgccaacttggacaacattcttttatgcgc2460
tcctttttagttatccccacctgcccagctcccttattaggctgagacattttaactaaa2520
ttatctgcttccctgactattcctagcctatagcctcacctcatttacacccttttcccc2580
agttcaacacctccttcgcctcctccccttgtacctccccaccttaatccacaagtatag2640
ggcacctctactccctccttggcgtccaattatgcacctcttaccatcccattaaaacct2700
aatcacccttaccccactcaatgccaatatcccatcccacagcatgctttaaaaggatta2760
aagcctgttatcacttgcctgttacagcacggccttttacagcctataaactctccttac2820
aattcctccattttacttgtccaaaaaccagacaagccttacaggttagttcaggatttg2880
tgccttatcaaccaaattgtcttgcctatccaacctgtgatgccaaagccatatactctc2940
ctatcctcaatacctccctccacaacccattattctgttctggatctcaaacatgttgtc3000
tttactatttctttgcacccttcatcccagcctctcttcacttttacttgaactgaccct3060
gacacccattaggctaagcaaattacctgggctatactgccacaaggcttcacagacagc3120
tcccattacttcagtcaagccgaaatttcttcctcatccgttacctatctcggcataatt3180
cttcatgaaaacacacgtgctctccctgctgattgtgtctggctaatctcccaaacccaa3240
ccccttctacaaaacaacaactcctttccttcctatgcatggttaggtacttccgccttt3300
ggatacctagttttaccatcctgactaaaccattatataaactcacaaaagcaaacctag3360
ctgaatccatagatcctaaatcctttccccactcctctttccattccttaaaaacagccc3420
tagaagctgctcccacactagctctccctaactcatcccgacccttttcattacacacag3480
ccaaactacagggctgtgcagtcaaaattcttacacaagagctgggaccacaccctgtag3540
cctttccatccaaacaacttgaccttacctttttaggctagcctctacattattcctgat3600
accacacctgacccccatggctgtatctctctaatccacctgacattcactccacttccc3660
catatttccttctttcctggtcctcaccctgatcacacttggtttattgatggcagttcc3720
accaggcctaattgccactcaccagcaaaagcaggctatgctatagtatcttccacatct3780
atcattgaggctactgctctgcctccctccactacctctcagcaagccgaactcattgcc3840
ttaactcgagccctcactcttgcaaaggaattacgtgtcaatatttatactgactccaaa3900
tatgccttccatatcctgcaccaccatgctgttatatgggctgaaagaggtttccttact3960
acgcaagggtcctccatcattaatgcctctttaatgaaaactcttctcaaggctgcctta4020
cttccaaagaaagctggagtcatacactgtaagggccaccaaaaggcatcagatcccatt4080
gctaggggcagcacttatgctgataaggtagctaaagaagcagttagcattccaacttct4140
atccctcacggcagtttttctccttctcatctggtcactcccacctactctcccactgaa4200
acttccacctatcaatctcttcccacacaagcaaatgcttcttggaccaaggaaaatatc4260
tccttcttgcctcacaggcccattctattctatcgtcatttcataacctcttccatgtag4320
gttacaagccgctagcccacctcttagaacctctcatttcctttccattgtggaaatcta4380
tccttaaggaaatcacttctcagtgttccatctgctattctactacccctcagggattgt4440
tcaggccccctcccttccctacacatcaagctcggggatttgccacccccaggactggca4500
aattgactttattcacatgcccaagtcaggaaactaaaatacctcttgatctgggtagac4560
acttttgctggatgtgtagaggcctttcccactgggtctgagaaggccaccatggtcatt4620
tcttcccttttgtcagacataattcctcagtttggctttctcacctctatacagtccaat4680
aacagaccagcctttactagtcaaatacccaagcaatttctcaggctcttggtattcagt4740
ggaactttcatacccctgaccgtcctcaatcttcaggaaagataaaacagactaatggtc4800
ttttcccaaaaactcaccaaccaagtaagtaattacactggacccccttgggcactctct4860
aattggatgtcctgggtcctcccaattcttagtcctttaatacctatttttctccttctt4920
ttattcagaccttatatcttctgtttaatttctcaattcatccaaaactgtatccaggcc4980
atcgccaatcattctatatgaaaaatgctccttctaatcacccacaatatcacccctgac5040
cacaaaatcttccttcaacttaatctctcccactctaggttcccacaccacccctaatcc5100
cgctcgaagcagccctgagaaacatcgcccattatctctccataccacccccaaaatttt5160
tcacctctccaacacttaaccactattttgttttgcttttcttattaacataagaagaca5220
ggaatgtcaggcctctgagcccaagctaagccatcatatcccctgtgacctgcacgtata5280
catccagatggcctgaagcaactgaagatccacaaaagaaatgaaaatagccttaactga5340
tgacattccaccattgtgatttgtttctgccccaccctaactgatcaatgtactttgtaa5400
tctccccaacccttaagaaggttctttgtaatctcccccacatcttaagaaggttctttg5460
taattctccccacccttgagaatgcactttgtgagatccactccctgcccacaaaacatt5520
gctcctaactccaccgcctaccccaaaacctataagaactaatgataatcccaccaccct5580
ttgctgactctcttttcggactcagcccacctgcacccgggtgaaataaacagccttgtt5640
gctcacacaaagcctgtttggtggtctcttcacacagacgtgcatga5687
<210>27
<211>7457
<212>dna
<213>智人
<400>27
gtcaggcctctgagcccaagctaagccatcatatcccctgtgacctgcacgtacacatcc60
agatggccagttcctgcctcaactgatgacattccaccacaaaacaggtgaaaatggcct120
gttcctgccttaactgatgacattatcttgtgaaattccttctcctggctcatcctggct180
caaaagctcccctactgagctccttgtgaccccactcctgcctgccagagaacaatcccc240
ctttttcctttacctacccaaatcctataaaacggccccacccgtatctcccttcaatga300
ttctcttttcggactcagcctgcctgcacccaggtgaaataaacagccttgctgctcaca360
caaagcctttttggtggtctcttcacaccgaagcgcatgaaagttggtgctgtgactcgg420
atagggggacctcccttgggagatcaatcccctgtcctcctgctctttgctccatgaaaa480
agatccacctacgacctcgggtcctcagacccaccagcccaaggaacatctcaccaattt540
taaatcgggtaagcggcctcttcttactctcttctccaacctctctcactatccctcaac600
cactttctcctttcaatcttgatgctacccttcaatctctcctttctcttaatttccttt660
cattttctagtagagacaaaggagacacgttttatccgtggacccaaaactctggcgcca720
gtcacggactcaggaaggcagccttcccttggtgtttaatcattgcagggacgcctctga780
ttattcacctatgtttcagagatgtctgaccacccaaggacgcctgccttggtccttcac840
ccttagtggcaagtactgcttttctggggggcaagaaccccccaaccccttctctccatg900
tctctaccccttttccacttttctggagggcaagaacctccaaccccttctccttcaccc960
ttagtggcaagtaccgcttttctagggggcaaaaaccccccaaccccttctctccatgtc1020
tctaccccttctctgattttctgggggcaagaacccctggatccataatttccacgcccc1080
gacctcttatctctgcaccccgatcccttatttctacgcctcgacctcttatctctgtgc1140
ccaacccctttcctgcttttctggagggtaagaacccccgaaccccttccctccgtgtct1200
ctactctctcttttctctgggcttgcctccttcgctatgggcaaccttccaccctccatt1260
cctcctccttctcccttagcctgtgttcttaagaacttaaaacctcttcaactcacacct1320
gacctaaaacctaaatgccgaattttcttctgcaatgccgcttgaccccaatacaaactc1380
gacagtggttccaaatagccagaaaatggcactttcaatttttccatcctacgagatcta1440
aataattcttgtcataaaataggcaaacggtctgagatgcctgacgtccaggcattcttt1500
tacacatcggtccctccctagtctctgttcccaatgcaacttatcccaaatcttccttct1560
ttccctcccacctgtcccctcagtcccaaccccaagcatcgctgagtctttctaatcttc1620
cttttctacagacccatctgacttctcccctcctcgccaggccgagctaagtcccaattc1680
ttcctcagcctctgctcctccaccctacaatccttttatcacctcccctcctgaaacctg1740
gtccggcttacagtttccttccgtgactatccctcccccacctgcccagcaatttcctct1800
taaaaaggtggctggagctagaggcatagtcaaggttaatgctcctttttctttatccca1860
aatcagatagcgtttaggctctttttcatcaaatataaaaacccagcccagttcatggat1920
cgtttggcagcaaccctgagatgctttacagccctaggccctaaaaggtcaaaaggccgt1980
cttattcttaatatatattttattacccaatctgctcccgacattaaataaaactccaaa2040
aattaaattccggccctcaaatcccacaacaggacttaattaacctcaccttcaaggtgt2100
acaataatagagtagaggcagccaagtagcaatgtatttctgagttgcaattccttacct2160
ccactgtgagacaaaccccagccacatctccagcacacaagaactccaaatgcccaaacc2220
gcagctgcaaggggttcctccagaacctccaccctcaagagcttgctataagtgtgagaa2280
atctggccaattggccaaggaatgcccacagcccgggattcctcctaagccgcgtcccat2340
ctgtgcaggaacccactgaaaatcagactgttcaactcacctggcagccgctcccagaac2400
ccctggaactctggcccaaggctctctgactgactccttcccagatcttctcagcttagc2460
agctgaagactgacactgcccgattgcctcggaagcctacaggaccatcacagacgctct2520
aggtaactctcacagtggaaggtaagtctgtccccttctaaatcaataccgaggctaccc2580
actccatattaccttcttttcaagggcctgtttcccttgcctccataactgttgtgggta2640
ttgacggccaggcttctaaacctcttaaaaactccccaactctggtgccaacttagaaga2700
cactctttttgcactcttttttaattatccccacctgcccagttcccttattaggccgag2760
acactttaactaaattatctgcttccctgactactcctgggctacagccacacctcattg2820
ccaccttttcccccagttcaaagcctccttcacatcctccccttgtatctccccacctta2880
acccacaagtatatgaccctctactccctccttagcgaccatcatgcaccccttaccatc2940
ccattaaaacctaatcacccttaccctgctcaatgccaatatcccatcccacagcatgct3000
ttaaaaggattaaagcctgttaccactcgtgtgctacagcatggccttttaaagcctgta3060
aactccccttacaattccatttcacctgtcctaaaaccagacaagccttacaggttagtt3120
caggatctgcgccttatcaaccaaactgttttgcctatccaccccgtggtgccaaacgca3180
tatactctcctatcctcaatacctctctctacaacccattattctgttctggatttcaga3240
catgctttctttactattcctttgcacccttcatcccagcctctcttcgctttcacttgg3300
actgaccctgacacccattaggctcagcagattacctgagctgtactgccgcaaggcttc3360
acagacagccccctttacttcagtcaagcccaaatttcttcctcatcagtttcctatctc3420
agcataattctcataaaaacacacatgctctccctgctgatcatgtccgagtaatctccc3480
aaacctcaatcccttataaaacaacaactcctttccttcctaggcatggttagcgcagtc3540
agaattctttcacaagagccgggaccgcaccctgtagcctttctgtccaaacaactttga3600
ccttactgttttagcctagccctcatgtctgtgtgcagtggctgccgctgctttaataat3660
tttagaggccctaaaaatcacaaactgtgctcaactcactctacatttctcataacttcc3720
aaaatctcttctcttcctcatacctgacacgtatactttctgctccccggctccttcagc3780
tgtactcactctttgttgagtctcccacaattaccattgttcctggcacggacttcaatc3840
tggtctcccacattattctggataccacacctgaccctcatgattgtatctctctgatcc3900
acctgacattcacctcatttccccatatttccttctttcctttttctcaccctgatcaca3960
tttagtttattggtggcagttccaccaggcctaatcgccactcaccagcaaaggcaggct4020
atgctatagtatcttccacatctatcattgaggctaccgctttgcccccctccactacct4080
ctcagcaagccaaattagttgccttaactcaagtcctcactcttgaaaaaggactacgcg4140
tcaatatttacactgactctaaatatgcctttcatattctgcaccatcatgctgttatat4200
aggctgaaggaggtttcctcactacgcaagggtcctccatcattaatgcctctttaataa4260
aaactctgctcaaggcggctttacttccaaaggaagctgcagtcattcactgcaaaggcc4320
atcaaaaggcgtcagatcccattgctctaggcaacgattatgctgataaggtggctagac4380
aagcagctagatttccaacttctgtccttcacggccagttttcctccttcgtatcagtca4440
ctcccacctactcccccgctgaaacttccacctatcaatctcttttccacacaaggcaaa4500
tggttcttagaccaaggaaaatatctccttccagcctcacaggcccgttctattctggtg4560
tcatttcataacctctcatgtaggttacaagccgctagcctgtctcttagaacctctcat4620
ttcctttccatcctggaaatctatcctcaaggaaattacttctcagtgttccatctgcta4680
ttctactacccctcagggattgttcaggcctcctccctttcctacacatcaagctcaggg4740
atttgtccctgcccaggactagcaaattgactttactcacatgccctgagtcggaaaact4800
aaaatacctcttagtctaggtagacactttcactgggtgggtagaggcctttcccacagg4860
gtctgagaaggccatcgctgtcatttcttcccttctgtcagacataattcctcggtttgg4920
ccttcccacctctatacagtccgatagcagactggcctttattagtcaaatcagccaagc4980
attttttcaggctcttggtattcagtgaaacctttatatcccttacggtcctcagtcttc5040
aggaaaggtagaacggactaatagtcttttaaaaacacacctcaccaagctcagccacca5100
acttaaaaaggactggacaatacttttaccactttgccttctcagaattcaggcctgtcc5160
tcggaatgctacaaggtacagcccatttgagctcctgtatagacgctcctttttatttgg5220
ccccagtctcattccaggcaccaggccaacttagactgtgccccaaaaaacttgtcatcc5280
ctactatcttctgtctagtcatacacctattcaccgttttcaactactcatacatgccct5340
gctcttgtttacactgccagtttacactgttcctccaagccatcacagctgatatcccct5400
ggtgctatccgcaaactgccactcttaactcttaaagtaaataaataatctttgctggca5460
ggactatgctgaatctccttcgcactctctaattaaatgtcctaggtcctcccaattctt5520
agacctttaatacctggttttctccttctcttattccatttttcaattcatacaaaaccg5580
tatccaggccatcaccaataattctaaatgacaaatgtttcttctaacaaccccacaata5640
tcaccccttaccacaaaatcttccttcagcttaatctctcccactctaggttcccacgcc5700
acctctaatcccgctggaagtagccctgagaaacatcgcccattatctctccataccacc5760
cctaaaaattttcactgtcccaacactttaccacaatttcattttatttttcttattaat5820
ataagaagtcaggaatgtcaggcctctgagcccaagctaagccatcatatcccctgtgac5880
ctgcaggtacacatccagatggccagttcctgccttaactgatgacattccaccacaaaa5940
caagtgaaaatggcctgttcctgccttaactgatgacattccaccacaaaacaagtgaaa6000
atggcctgttcctgccttaactgatgacattatctggtgaaattccgtctcctggctcat6060
cctggctcaaaagctcccctactgaccaccttgtgacccccacccctgcctgccagagaa6120
taacccccctttttcctttacctacccaaatcctataaaacagccccacccctatctccc6180
ctcactgactctctttttggactcagcccacctgcacccaggtgaaataaacagccttgc6240
tgctcacacaaagcctgttgggtggtctcttcacacggacgtgcatgaaaactttgaagc6300
aggcattttgctgtattatctcaataacatttttataacatgttgaggtagatcttacgt6360
tcattttacaaatgagaatactaagatgtggagagcttaaccaatttaagcctgaagtta6420
caatttaatagcaggaaggtggacaaacgttttttccgttctccaattcctactgcctcc6480
taaacatgttttacagacatgggcctcttaacaatgggacatgccctgagaaatgcatca6540
ctaggcaatttctttgttatgtgaacattacagtgtacctacacaaacttagaaggtata6600
gcttactacatacctaggctatatggtagagcctattcctactaggctacaaatttggaa6660
acatgtcattctactgaatactgccggcaattacaacgcaatggtagttgtgtatttaaa6720
cgtgtctacacatagaaaagctacaataaaaataacagtattataatcttacgggaccat6780
catcatataagcagcgcattcctgactgaaatgttggttaggcagtacatcactgtattt6840
ctttcattcttagaaaatgaagtgaaggggaatataatttattttcatatacctacctct6900
tctcaacaagttccttatattttttggccataggggaagattctaatattcacatctgaa6960
tatcaattacctttaagcaaaatatagtgtcttcataacccagaacttgaaaaatcacaa7020
aacttgttttcctggtacattgtgtcaggcctctgagcccaagctaagccatcatgtccc7080
ctgtgacccacatgtacacatccagatggctggttctttccttaactgacgacattccac7140
cacacaacaagtgaaaaatggcctgttcctgccttaactgatgacattatcttgtgaaat7200
tccttctcctggctcatcctggctcaaaagctcccctgctgagcacctcgtgaccccccc7260
actcctgcctgccagagaacaacccccctttgactgtaattttcctttacctacccaaaa7320
cttataaaacggccccacccctatctcccttcactgactcttttcggactcagcccgcct7380
gcacccaggtgaaataaacagccttgttgctcacaaaaagcctgtttggtggtctcttca7440
cacggacacgactgaaa7457
<210>97
<211>5815
<212>dna
<213>智人
<400>97
gtcaggcctctcagcccaagctaagccatcatatcccctgtgacctgcatgtacacatcc60
agatggccagttcctgccttaactgatgacattccaccacaaaagaaatgaaaatggcct120
gttcctgccttaactgatggcattatcttgtgaaattccttctcctggctcatcctggct180
caaaagctcccctactaagcaccttgtgacccccactcctgcctgccagagaactacccc240
cctttcctttacctacccaaatcctatagaatggctccaccccgtctcccttcgctgact300
ctctttttggactcagcccacctgcacccaggtgaaataaacagccttgttgctcacaca360
aagcttgtttggtggtcttttcacatggatgtgagtgaaatttggtgccatgactcagat420
cgggcaagctcccttaggagatcaatcccctgtcctcctgctctttgctccgtgagagag480
agccacctatgacttctggtcctcagaccaagcagcccaagcaagatctcaccaatttta540
aatctggtaagcagcctctttttactctcttctccaacctccctcactatccctcaacct600
ctatctcctttcaatcttggtgccacacttcaatctctcccttctcttaatttcaattcc660
tttcattttctggtagagacaaaggaggcacattttatccgtggacccaaaactctggcg720
ctggtcatggactagggaaggcagccttcccttggtgtttaatcattgcagggacacctc780
tctgattattcacccaggtttcagaggtgtcagaccacgcagggacgcctgtcttggtcc840
ttcacccttagcggcaagtcctgcttttctgggggaggggcaagaacccttcaacacctt900
ctctttcacccttagtggcaagtcccgcttttctggaggaggggcaggaatcccgaccta960
atatctctgcaccccgatcccttatttccatgccccaacctcttatctctgtgccccaac1020
cccatatttccacgccctgaccccttctctgcttttctggagggcaagaaccccccaccc1080
cttctctgtgtctctactctcttttctctgggcttgcctccttcactatgcacaagcttc1140
caccttccattcctccttcttctcccttagcctgtgttcttaagaacttaaaacctcttc1200
aattctcacctgacctaaaatctaagcatcttattttcttttgcaatgccgcttgacccc1260
aatacaaactcgacagtagttccaaatagccggaaaatggcactttcaatttttccatcc1320
tacaagatctaaataattcttgtcaaaaaatggccaaatggtctgaggtgcctgacatcc1380
aggcattcttttatacatcggtccctccctagtctctgttcccaatgcaactcgtcccaa1440
atcttccttctttccctcccacctgtctcctcagtcccaaccccaagcatcactgagtct1500
ttctaatcttccttttctacagacccatctgacctctcccctcctccccaggctgctcct1560
caccaggctgagctaggtcccaattcttcctcagcctccactcctccaccctataatcct1620
tttatcacctcccctcctcacaccaggtctggcttacagtttcattccctgactggccct1680
ccccaacctgcccagcaatttactcttaaaaagttggctggagttaaaggcatagtcaaa1740
gttagtggtcctttttctttatcccaaatcagatagcatttaggctctttttcatcaaat1800
ataaaaatccagcccagttcatgactcgtttggcagcaaccctgagatgctttacagccc1860
tagaccctaaaaggtcaaaaggccgtcttattctcaatatacattttattacccaatctg1920
ctcccgatattaaataaaactccaaaaattaaattccagccctcaaaccccacaacagga1980
cttaattaacctcgccttcaaggtgtacaataatagagtagaggcagccaagtagcaaca2040
tatttctgagttgcaattccttgcctccactgtgagacaaaccccagccacatctccagc2100
acacaagaacttccaaacacctaaaccgcagtggccaggtgttcctccagaacctcctcc2160
cccaggagcttgctacaagtgccagaaatctggccaccaagccaaggaatgcctgcagcc2220
cgggattcctcctaagctgtgtcccatctgtgggggaccccagtggaaatcagactgttc2280
aactcacctggcagccactcccagagcccctggaactctggcccaaggctctctgctgac2340
tccttcccagatcttcttggcttagcggctgaagactgacactgcccgattgcctcggaa2400
gccctgtagaccatcacggacgccgagctttaggtaactctcacggtggagggtaagtcc2460
gtccccttctgaatcaatacggaggctacctactccacattactttcttttcaagggcct2520
gtttcccttgcctccataactgttgtgggtattgacagccaggctgctaaacctcctaaa2580
actccccaaatctggtgtcaacttagacaatactcttttaagcactcctttttagttatc2640
cccacctgcccagtttccttattaggctgagacactttaactaaattatctgcttccctg2700
actattcctggagtacagctacatctcattgccgcccttcttcccaatccaaagcctcct2760
ttgcttcctcctcttgcatccccccaccttaacccacaagtataagatatctctactccc2820
tccttggtgaccaatcatgcaccccttaccatctcattaaaacctaatcacccttgccct2880
gcttaatgccaatatcgcatcccacagcatgctttgaaaggattaaagcctgttatcact2940
cgcctgctacagcgtggccttttaaagcctataaactctccttacaattcccccatttta3000
cctgtcctaaaaccagacaagccttacaagttagttcaggatctatgccttatcaaccaa3060
attgttttgcctatccaccccatggtgctaaacccatatactctcctatacttgataact3120
ccctccacaatccattattctgttctggatctgaaacatgctttctttactattcctttg3180
cacccttcatcccagcctctctttgctttcacctggactgaccctgacacccatcaagct3240
cagcaaattacctaggctttactgctgcaaagcttcacagatagcccccattacttcagt3300
caagcccaaatttcttcctcatctgttacctatctcagcataattctcagaaaaacacat3360
gcactctccctgctgatcgtgtccagctaatctcccaaaccccaatcccttctacaaaac3420
aacaactcctttccttcctgggcatggttggatactttcacgtttggatacctggttttg3480
ccatcctaacaaaaccattatataaactcacaaaaggaaacctagctgaccccatagatc3540
ctaaatcctttccccactcctctttccattccttgaagacagctttagaggctgccccca3600
tcctagctctccctgactcatcccaacccttttcattacacacagccgaagggcagggct3660
gtgaagtcggaattcttacacaaggaccgggatcacgtcctgtagcctttttgtccaaat3720
aacttgaccttactgttttaggctggccatcatgtctccatgcagcggctgctgccgccc3780
taatacttttagaggcccttaaaatcacaaaatatgctcaactcactctctacagctctc3840
ataatttccgaaatctattttcttcctcacacctgacacgtatactttctgctccctggc3900
tccttcagctgtactcactctttgttgagtctcccacaattaccattgttcctggctcgg3960
acttcaatgtggcctctcacattattcctgataccacacttgaccctcatgactgcatct4020
ctctgatccacctgacgttcaccccatttccccacatttccttcttccctgtttctcacc4080
ctgatcacacctggtttattgatggcagttccaccaggcctaatcgccacatgccagcaa4140
aggcaggctatgatatagtacaagccactagcctgcctcttagaacctctcatttccttt4200
ccatcatggaaatctatcctcaaggaaatcacttctcagtgttccatctgctattctgct4260
acttctcagggattattcaggccccctcccttccctacacatcaagctcagggatttgcc4320
cccacccaggactggcaaattagctttactcaacatgccccgagtcaggaaactaaaata4380
cctcttggtctaggtagacactttcactggataggtacaggcctttcccacagggtctaa4440
gaaggccaccacggtcacttcttcccttctgtcagtcaaaattactcggtttggccttcc4500
cacctctaggcagtccaatagtagaccggcctttattcatcaaatcagccaagcagtttt4560
tcaggctcttggtattcagtgaaacctttatatcccttacagtcctcagtcttcaggaaa4620
ggtagaatggactaatggtcttttaaaaacacacctcaccaagctcagtcaccaacttaa4680
aaaggactagacagtacttttacctctttcttttctcagaatttaggcctgtcctcagaa4740
tgctacagggtacagcccatttgagctcctgtatggacgctccattttattaagccccag4800
tctcattccagacatcagaccaacttggactgtgccccaaaaacttgtcatccctactat4860
cttctgtctagtcatactcctattcaccgttctcgactactcatatatgccctgctcttg4920
tttacactgccggtttacaccgtttctccaagccatcacagctgatatctcctggtgcta4980
tccccagactgccactcttaactcttaaagtaaataaataatctttgctggcaaggctat5040
gctgaacctccttaggcactctctaattagatgtcctaagtcctcccaattcttagtcct5100
ttaatacctgtttttctccttctcttattccctttagtttttcaatacatacaaaaccgt5160
atccaggccatcaccaataattctaaatgacaaatatttcttctaacagtcccacaatgt5220
caccccttaccacaaaatcttccctcagcttaatctctcccactctaggttcccatgcta5280
cccctaatcccgctcaaagcagccctgagaaacatcgcccattatctctccatactatcc5340
ccccaaattttcgccatcccaacactttaccactatttcgttttatttttctcattaata5400
taagaagacaggaatgtcaggcctccgagcccaagctaagccatcatatcccctgtgacc5460
tgcacatccacatccagatggccggttcctgccttaactgatgacattccaccacaaaag5520
aaatgaaaatggcctgttcttgccttaactgatggcattatcttgtgagattccttctcc5580
tggctcatcctggctcaaaagctcccctactgagcaccttgtgacccccactcctgcctg5640
ccagagaacaacccccctttttcctttacctacccaaaccctataaaacagccccacccc5700
tatctcccttcactgactctcttttcggacacagccctgcacccaggtgaaacaaacagc5760
cttgttgctcacacaaagcctgtttggtggcctcttcacagggacgcaagtgaaa5815