AALPAADRQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRASDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP AEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQFGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVKDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVYNPR QGFIANWNNQPMRGYPSTDLFAIVWGQADRYAEIETRLKAMTANGGKVSAQQMWDLIRTTSYADVNRRHFLPFLQRA VQGLPADDPRVRLVAGLAAWDGMMTSERQPGYFDNAGPAVMDAWLRAMLRRTLADEMPADFFKWYSATGYPTPQAPA TGSLNLTTGVKVLFNALAGPEAGVPQRYDFFNGARADDVILAALDDALAALRQAYGQDPAAWKIPAPPMVFAPKNFL GVPQADAKAVLCYRATQNRGTENNMTVFDGKSVRAVDVVAPGQSGFVAPDGTPSPHTRDQFDLYNTFGSKRVWFTAD EVRRNATSEETLRYPR；
[0022] SEQ ID NO:6,其为SEQ ID NO: 1第232位的A替换为E的突变体，其氨基酸序列为：
[0023] MKQQWLSAALLAASSCLPAMAAQPVAPAAGQTSEAVAARPQTADGKVTIRRDAYGMPHVYADTVYGIFYGYGYAVAQ DRLFQMEMARRSTQGRVAEVLGASMVGFDKSIRANFSPERIQRQLAALPAADRQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRFSDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP EEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQFGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVKDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVYNPR QGFIANWNNQPMRGYPSTDLFAIVWGQADRYAEIETRLKAMTANGGKVSAQQMWDLIRTTSYADVNRRHFLPFLQRA VQGLPADDPRVRLVAGLAAWDGMMTSERQPGYFDNAGPAVMDAWLRAMLRRTLADEMPADFFKWYSATGYPTPQAPA TGSLNLTTGVKVLFNALAGPEAGVPQRYDFFNGARADDVILAALDDALAALRQAYGQDPAAWKIPAPPMVFAPKNFL GVPQADAKAVLCYRATQNRGTENNMTVFDGKSVRAVDVVAPGQSGFVAPDGTPSPHTRDQFDLYNTFGSKRVWFTAD EVRRNATSEETLRYPR；
[0024] SEQ ID NO:7,其为SEQ ID NO: 1第330位的F替换为A的突变体，其氨基酸序列为：
[0025] MKQQWLSAALLAASSCLPAMAAQPVAPAAGQTSEAVAARPQTADGKVTIRRDAYGMPHVYADTVYGIFYGYGYAVAQ DRLFQMEMARRSTQGRVAEVLGASMVGFDKSIRANFSPERIQRQLAALPAADRQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRFSDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP AEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQAGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVKDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVYNPR QGFIANWNNQPMRGYPSTDLFAIVWGQADRYAEIETRLKAMTANGGKVSAQQMWDLIRTTSYADVNRRHFLPFLQRA VQGLPADDPRVRLVAGLAAWDGMMTSERQPGYFDNAGPAVMDAWLRAMLRRTLADEMPADFFKWYSATGYPTPQAPA TGSLNLTTGVKVLFNALAGPEAGVPQRYDFFNGARADDVILAALDDALAALRQAYGQDPAAWKIPAPPMVFAPKNFL GVPQADAKAVLCYRATQNRGTENNMTVFDGKSVRAVDVVAPGQSGFVAPDGTPSPHTRDQFDLYNTFGSKRVWFTAD EVRRNATSEETLRYPR；
[0026] SEQ ID NO:8,其为SEQ ID NO: 1第415位的K替换为E的突变体，其氨基酸序列为：
[0027] MKQQWLSAALLAASSCLPAMAAQPVAPAAGQTSEAVAARPQTADGKVTIRRDAYGMPHVYADTVYGIFYGYGYAVAQ DRLFQMEMARRSTQGRVAEVLGASMVGFDKSIRANFSPERIQRQLAALPAADRQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRFSDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP AEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQFGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVEDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVYNPR QGFIANWNNQPMRGYPSTDLFAIVWGQADRYAEIETRLKAMTANGGKVSAQQMWDLIRTTSYADVNRRHFLPFLQRA VQGLPADDPRVRLVAGLAAWDGMMTSERQPGYFDNAGPAVMDAWLRAMLRRTLADEMPADFFKWYSATGYPTPQAPA TGSLNLTTGVKVLFNALAGPEAGVPQRYDFFNGARADDVILAALDDALAALRQAYGQDPAAWKIPAPPMVFAPKNFL GVPQADAKAVLCYRATQNRGTENNMTVFDGKSVRAVDVVAPGQSGFVAPDGTPSPHTRDQFDLYNTFGSKRVWFTAD EVRRNATSEETLRYPR；
[0028] SEQ ID NO:9,其为SEQ ID NO: 1第798位的F替换为L的突变体，其氨基酸序列为：
[0029] MKQQWLSAALLAASSCLPAMAAQPVAPAAGQTSEAVAARPQTADGKVTIRRDAYGMPHVYADTVYGIFYGYGYAVAQ DRLFQMEMARRSTQGRVAEVLGASMVGFDKSIRANFSPERIQRQLAALPAADRQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRFSDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP AEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQFGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVKDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVYNPR QGFIANWNNQPMRGYPSTDLFAIVWGQADRYAEIETRLKAMTANGGKVSAQQMWDLIRTTSYADVNRRHFLPFLQRA VQGLPADDPRVRLVAGLAAWDGMMTSERQPGYFDNAGPAVMDAWLRAMLRRTLADEMPADFFKWYSATGYPTPQAPA TGSLNLTTGVKVLFNALAGPEAGVPQRYDFFNGARADDVILAALDDALAALRQAYGQDPAAWKIPAPPMVFAPKNFL GVPQADAKAVLCYRATQNRGTENNMTVLDGKSVRAVDVVAPGQSGFVAPDGTPSPHTRDQFDLYNTFGSKRVWFTAD EVRRNATSEETLRYPR;或者
[0030] SEQ ID NO: 10,其为SEQ ID NO: 1第44位的D替换为L、第130位的R替换为M、第186 位的F替换为A、第232位的A替换为E、第330位的F替换为A、第415位的K替换为E、第798位的F 替换为L的突变体，其氨基酸序列为：
[0031] MKQQWLSAALLAASSCLPAMAAQPVAPAAGQTSEAVAARPQTALGKVTIRRDAYGMPHVYADTVYGIFYGYGYAVAQ DRLFQMEMARRSTQGRVAEVLGASMVGFDKSIRANFSPERIQRQLAALPAADMQVLDGYAAGMNAWLARVRAQPGQL MPKEFNDLGFAPADWTAYDVAMIFVGTMANRASDANSEIDNLALLTALKDRHGAADAMRIFNQLRWLTDSRAPTTVP EEAGSYQPPVFQPDGADPLAYALPRYDGTPPMLERVVRDPATRGVVDGAPATLRAQLAAQYAQSGQPGIAGFPTTSN MWIVGRDHAKDARSILLNGPQAGffffNPAYTYGIGLHGAGFDVVGNTPFAYPSILFGHNAHVTWGSTAGFGDDVDIFA EKLDPADRTRYFHDGQWKTLEKRTDLILVEDAAPVTLDVYRSVHGLIVKFDDAQHVAYAKARAWEGYELQSLMAWTR KTQSANWEQWKAQAARHALTINWYYADDRGNIGYAHTGFYPRRRPGHDPRLPVPGTGEMDWLGLLPFSTNPQVY