64, 116. 4, 96. 19, 78. 49, 78. 39, 50. 22, 37. 51，：M. 25, 33. 76, 28. 70, 27. 05, 25. 96, 22. 36, 22. 22, 21. 79。
[003引（2R, 3R, 3aR,6S, 7aS, E) -3-hyd;roxy-2-isopentyl-3,6-dimethylhexah ydrobenzofuran-4 (2H)-0ne0-(3-chlorobenzoyl)oxime(B85) : white solids；Yield 76 %；m. p. 141-143 °C ;MS(ES0m/z:430. 17 (M+Na)+;古NMRKDCIs, 400 MHz) δ :8. 05(s, IH), 7. 97(d, J = 7.8Hz, IH), 7. 58 (d, J =8. OHz, IH), 7. 43 (t, J = 7. 9Hz, IH)，4. 36 - 4. 28 (m, IH)，3.66- 3. 59 (m, IH)，3. 15 (d, J = 15. 4Hz, IH)，3. 07 (d, J = 9. IHz, 1H)，2. 13-2. 03(m, IH), 1.92(dd, J = 15.6, 12.6Hz, IH), 1.70 - 1.45(m，IIH), 1.4 2(s，3H), 1.30(s, IH), 1.05(d, J =6. 4Hz，3H)，0. 92(d, J =6. 4Hz，6H) ;"C NMR(CDCl3, 100 MHz) δ：169. 15, 162. 87, 134. 73, 133. 34, 130.88, 129. 89, 129. 65, 127. 75,86. 93, 80. 79, 76 .25, 51. 12, 40. 16, 35. 90,：M. 76, 28. 26, 27. 16, 27. 11，23. 13, 22. 54, 22. 45, 21. 90。
[0037] (2Z, 3R, 3aR, 4E,6S, 7aS)-3-hydroxy-3,6-dimethy 1-2-(3-methyIbuty 1 i dene)hexahydrobenzofuran-4(2H)-one〇-phenylcarbamoyl oxime化35) : white solids ;Yield 54 % ;m. p. 117-119 °C ;MS (ESI)m/z : 409. 21 (M+化Γ;IR: v max/cm i (KBr) 3456, 2955, 2868, 1639, 1462, 1385, 1165, 1098, 1038, 985 ;1h應R(CDC!3, 400 MHz) δ :8. 16(s, IH), 7. 47(d, J = 7.細z, 2H), 7. 33(t, J = 7. 9Hz, 2H), 7. 11 (t, J = 7.4Hz，lH)，4.60-4.41(m，2H)，3.35 - 3.25 (m，lH)，2.87(d，J = 8.1Hz，lH)，2.09-1.93(m，3H)，1.93 - 1.82(m，IH), 1.64(ddd, J = 20.8, 18. 9, 11.8Hz，3H), 1.51(s，2H), 1.05 (d, J =6. 4Hz, 2H), 0. 91 (d, J =6.細z,6H) ;1化NMR(CDCl3, 100 MHz) δ : 164. 44, 160. 20, 15 2. 14, 137. 01, 129. 03, 124. 16, 119. 58, 96. 19, 78. 52, 78. 11, 50. 40, 37. 50, 33. 94, 33. 75, 28 .67, 27. 05, 25. 87, 22. 30, 22. 20, 21. 61〇
[003引（2Z, 3R, 3aR, 4E,6S, 7aS)-3-hyd;roxy-3, 6-dimethyl-2-(3-methylbut ylidene) hexahydrobenzofuran-4 (2H)-one 0-benzyl oxime (B30) : colorless oil ；Yield 7 5 %；MS(ESI)m/z:380.21 (M + Na)"；IR: v ' (K Br) 3456, 2955, 2868, 1639, 1462, 1385, 1165, 1098, 1038, 985 ;1h匪R(CDCl3, 400 MHz) δ：7. 37 - 7. 29 (m, 5H), 5. 12 (d, J = 1.8Hz, 2H), 4. 51 - 4. 40 (m, 2H), 3. 09 (dd, J = 8. 9, 7. OHz, IH)，2. 72 (d, J = 7. 9Hz, IH)，2. 02 - 1. 91 (m, 3H)，1. 85 (s, IH)，1. 78 (dd, J = 15.8, 11.5Hz, IH), 1.66 - 1.52 (m，5H), 1.39 (s，3H), 1.01 (d，J = 6.0Hz, 3H), 0.89 (d，J = 6.6Hz,6H) ;1化NMR(CDCl3, 100 MHz) δ : 160. 39, 157. 91，138. 07, 128. 32, 128. 01，127. 70, 9 5. 44, 78. 57, 78. 20, 75. 71, 50. 16, 37. 71, 33. 78, 32. 85, 28. 77, 26. 93, 26. 20, 22. 35, 22. 23, 21. 70。
[0039] (2Z, 3R, 3aR, 4E,6S, 7aS)-3-hy化〇巧-3, 6-dimethyl-2-(3-methy化utylidene) hexahydrobenzofuran-4(2H)-one O-prop-2-yn-1-yl oxime度34):colorless oil ；Yield 41 % ;IR: V max/cm 1 (邸r) :3456, 2955, 2868, 1639, 1462, 1385, 1165, 1098, 1038, 985 ;1h NMR (CDCI3, 400 MHz) 5:4.73 - 4.58 (m, 3H), 4. 55 - 4. 40 (m, 2H), 3. 11 - 2. 99 (m, IH), 2. 81 -2. 69 (m, IH), 2. 51 - 2. 37 (m, 2H), 2. 02 - 1.88(m, 4H), 1. 83 - 1. 65 (m, 3H), 1. 64 - 1. 49 (m, 5H)，1. 46 (s, 3H)，1. 01 (d,J=6.IHz, 4H)，0. 89 (d,J=6.6Hz, 7H) ;1化 NMR(CDCl3,lOOMHz)δ: 160. 41，158. 92, 95. 58, 78. 57, 78. 18, 74. 17, 61. 16, 50. 08, 37. 71，3 3. 78, 32. 73, 28. 75, 26. 94, 26. 07, 22. 34, 22. 22, 21. 69〇
[0040] (2Z, 3R, 3aR, 4E,6S, 7aS)-3-hy化oxy-3, 6-dimethyl-2-(3-methy化utylide ne)hexahydrobenzofuran-4 (2H)-one0-acetyloxime(B31):colorlessoil；Yield52 % ;IR:Vmax/cm1 (邸r) :3456, 2955, 2868, 1639, 1462, 1385, 1165, 1098, 1038, 985 ;1h NMR(CDCI3, 400MHz)δ: 4. 50 (t,J= 7. 4Hz, 2H)，3. 07 (dd,J= 16. 1，3. 3Hz,IH)，2. 94 (d,J=8.IHz,IH), 2. 21 - 2. 16 (m, 4H), 2. 16 - 2. 13 (m,IH), 2. 05 - 1. 99 (m,IH), 1. 95 (t,J= 7.IHz, 3H)，1. 89 - 1. 80 (m,IH)，1. 72 (s, 2H)，1.66- 1. 55 (m, 4H)，1. 52 (s, 2H)，1. 50 (s, 3H) ，1.44扣J= 4.IHz,IH), 1.03扣J= 5. 9Hz，4H)，0. 92 - 0.86(m,lOH);"CNMR(CDCl3, 100MHz)δ: 168. 64, 166. 55, 160. 28, 96. 04, 78. 43, 78. 36, 50. 16, 37. 55, ：M. 00, 33. 75, 28. 69, 2 7. 00, 25. 96, 22. 32, 22. 19, 21. 69, 19. 62〇
[0041] (3R, 3aR,6S, 7aS,E)-3-hyd;roxy-2-isopentyl-3,6-dimethylhexahyd robenzofuran-4 (2H)-one0-(4-chlorobenzoyl)oxime(B86) :whitesolids；Yield64 147-148 °C;MS(ESI)m/z:430.19(M+Nar;iH應R(CDC!3, 400 MHz)5:8.17(s，lH)，7.44-7.41(m，2H)，7.29(dd，J= 6.9,4.7Hz，3H)，4.56- 4. 47 (m, 2H) , 3. 32 - 3. 25 (m, IH) , 2. 86 (d, J = 8. 1 Hz , 1H) , 2. 04 (dd, J = 12. 1，6. 3Hz, 2H)，2. 00 - 1. 94 (m, 3H)，1. 92 - 1. 86 (m, IH)，1. 77 (s, IH)，1. 70 (dd, J = 12. 3, 4.細z, 2H)，1. 66 - 1. 63 (m, IH)，1. 61 (d, J = 6. 5Hz, IH)，1. 58(t,J = 4. 4Hz, IH)，1. 5 1 (s, 3H)，1. 25 (s, IH)，1. 05 (d, J = 6. 4Hz, 3H)，0. 90 (d, J = 6.細z, 7H) ;"C NMR(CDCl3, 100 MHz)δ：164. 79, 160. 18, 152. 04, 135. 63, 129. 28, 129. 08, 120. 79, 96. 30, 78. 52, 78. 14, 76. 68, 50. 39, 37. 48, 33. 98, 33. 74, 28. 69, 27. 08, 25. 91, 22. 32, 22. 21, 21. 63〇
[0042] (2Z, 3R, 3aR, 4E,6S, 7aS)-3-hy化〇巧-3, 6-dimethyl-2-(3-methy化utylidene) hexahydrobenzofuran-4 蚀）-one0- ((4-fluorophenyl)carbamoyl)oxime度61) :white solids;Yield63 127-129 °C;MS(ESI)m/z:427.19(M+化r;IR:Vmax/cmi (KBr) 3456, 2955, 2868, 1639, 1462, 1385, 1165, 1098, 1038, 985 ;1h應R(CDC!3, 400MHz)δ:8. 15(s,IH), 7. 47 - 7. 39 (m, 2H), 7. 03(t,J=8.6Hz, 2H), 4. 52(dt,J= 11.0,7. 0Hz，2H), 3.30 (d，J= 13.8Hz，lH), 2.86 (d，J= 8.1Hz,IH), 2.04 (dd，J= 12. 1，6. 2Hz,IH)，2. 00 - 1. 93 (m, 3H)，1. 92 -