亚氨基取代的苯乙酰胺、它们的制备及含有它们的杀真菌剂的制作方法

专利名称：亚氨基取代的苯乙酰胺、它们的制备及含有它们的杀真菌剂的制作方法
技术领域：
本发明涉及下式所示取代的苯乙酰胺 式中各取代基的意义如下Y为氧原子或基团NR6；Z1和Z2相互独立地为氢原子、卤原子、烷基、链烯基、链炔基、烷氧基、链烯基氧基、卤代烷基、卤代烷氧基、卤代链烯基氧基、氰基或硝基；R1为氢原子、烷基、卤代烷基或芳基；R2为氢原子，或者为取代或未取代的烷基、链烯基、链炔基、环烷基、杂芳基烷基、杂环基、环烯基、芳烷基、芳基、杂芳基、芳基链烯基、杂芳基链烯基、芳氧基烷基、杂芳氧基烷基、酰基、芳基羰基、杂芳基羰基或烷氧羰基R3、R4、R5和R6相互独立地为氢原子或烷基；或者R6和R2同与它们相连的氮原子一起形成环。
本发明还涉及制备这些化合物的方法和中间体。
已知可使用亚氨基取代的苯乙酸衍生物作杀真菌剂(EP499823)。但是在许多情况下它们的功效不能令人满意。
因此，本发明目的是改进了功效和更广谱的化合物。
本申请人发现了上述定义的化合物I。
还发现式I所示化合物具有良好的杀昆虫、杀线虫和杀螨活性。杀真菌活性是优选的。
考虑到它们的防治有害真菌的生理活性，适宜的化合物I例如是其中的取代基具有如下意义的化合物Z1和Z2是氢原子，卤原子如氟、氯、溴和碘原子，或者例如甲基、甲氧基、氰基和硝基；R3、R4、R5和R6是氢原子，C1—C6烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基、1，1—二甲基乙基、戊基、1—甲基丁基、2—甲基丁基、3—甲基丁基、2，2—二甲基丙基、1—乙基丙基、己基、1，1—二甲基丙基、1，2—二甲基丙基、1—甲基苯基、2—甲基戊基、3—甲基戊基、4—甲基戊基、1，1—二甲基丁基、1，2—二甲基丁基、1，3—二甲基丁基、2，2—二甲基丁基、2，3—二甲基丁基、3，3—二甲基丁基、1—乙基丁基、2—乙基丁基、1，1，2—三甲基丙基、1，2，2—三甲基丙基、1—乙基—1—甲基丙基和1—乙基—2—甲基丙基；R1是*氢原子，*C1—C4烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基和1，1—二甲基乙基，*C1—C4卤代烷基，特别是C1—C2卤代烷基，如氯甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、一氯一氟甲基、二氯一氟甲基、一氯二氟甲基、1—氟乙基、2—氟乙基、2，2—二氟乙基、2，2，2—三氟乙基、2—氯—2—氟乙基、2—氯—2，2—二氟乙基、2，2—二氯—2—氟乙基、2，2，2—三氟乙基和五氟乙基，*未取代或取代的芳基，如苯基、萘基和蒽基，优选苯基和萘基，特别是苯基；R2是*氢原子，如上所述的C1—C4烷基，*未取代或取代的C3—C15链烯基、特别是C3—C6链烯基，如2—丙烯基、2—丁烯基、3—丁烯基、1—甲基—2—丙烯基、2—甲基—2—丙烯基、2—戊烯基、3—戊烯基、4—戊烯基、1—甲基—2—丁烯基、2—甲基—2—丁烯基、3—甲基—2—丁烯基、1—甲基—3—丁烯基、2—甲基—3—丁烯基、3—甲基—3—丁烯基、1，1—二甲基—2—丙烯基、1，2—二甲基—2—丙烯基、1—乙基—2—丙烯基、2—己烯基、3—己烯基、4—己烯基、5—己烯基、1—甲基—2—戊烯基、2—甲基—2—戊烯基、3—甲基—2—戊烯基、4—甲基—2—戊烯基、1—甲基—2—戊烯基、2—甲基—3—戊烯基、3—甲基—3—戊烯基、4—甲基—3—戊烯基、1—甲基—4—戊烯基、2—甲基—4—戊烯基、3—甲基—4—戊烯基、4—甲基—4—戊烯基、1，1—二甲基—2—丁烯基、1，1—二甲基—3—丁烯基、1，2—二甲基—2—丁烯基、1，2—二甲基—3—丁烯基、1，3—二甲基—2—丁烯基、1，3—二甲基—3—丁烯基、2，2—二甲基—3—丁烯基、2，3—二甲基—2—丁烯基、2，3—二甲基—3—丁烯基、3，3—二甲基—2—丁烯基、1—乙基—2—丁烯基、1—乙基—3—丁烯基、2—乙基—2—丁烯基、2—乙基—3—丁烯基、1，1，2—三甲基—2—丙烯基、1—乙基—1—甲基—2—丙烯基和1—乙基—2—甲基—2—丙烯基，*未取代的或取代的C3—C8链炔基，如2—丙炔基、2—丁炔基、3—丁炔基、1—甲基—2—丙炔基、2—戊炔基、3—戊炔基、4—戊炔基、1—甲基—2—丁炔基、1—甲基—3—丁炔基、2—甲基—3—丁炔基、1，1—二甲基—2—丙炔基、1—乙基—2—丙炔基、2—己炔基、3—己炔基、4—己炔基、5—己炔基、1—甲基—2—戊炔基、1—甲基—3—戊炔基、1—甲基—4—戊炔基、2—甲基—3—戊炔基、2—甲基—4—戊炔基、3—甲基—4—戊炔基、4—甲基—2—戊炔基、1，1—二甲基—2—丁炔基、1，1—二甲基—3—丁炔基、1，2—二甲基—3—丁炔基、2，2—二甲基—3—丁炔基、1—乙基—2—丁炔基、1—乙基—3—丁炔基和1—乙基—1—甲基—2—丙炔基，*未取代的或取代的C3—C8环烷基，如环丙基、环丁基、环戊基、环己基、环庚基和环辛基，*(C1—C4烷氧基)羰基—(C1—C4烷基)，如甲氧羰基甲基、乙氧羰基甲基、丙氧羰基甲基、1—甲基乙氧羰基甲基、丁氧羰基甲基、1—甲基丙氧羰基甲基和1，1—二甲基乙氧羰基甲基，*未取代或取代的C5—C8环烯基，如环戊—1—烯基、环戊—2—烯基、环戊—3—烯基、环己—1—烯基、环己—2—烯基、环己—3—烯基、环庚—1—烯基、环庚—2—烯基、环庚—3—烯基、环庚—4—烯基、环己—2—烯基、环己—3—烯基、环庚—l—烯基、环庚—2—烯基、环庚—3—烯基、环庚—4—烯基、环辛—1—烯基、环辛—2—烯基、环辛—3—烯基和环辛—1—烯基，*未取代或取代的芳基(如苯基、萘基、蒽基)，*未取代或取代的芳基—(C1—C4)烷基(如苯甲基、1—苯乙基、2—苯乙基、1—苯丙基、2—苯丙基、3—苯丙基、2—甲基—3—苯丙基、2—甲基—2—苯丙基、4—苯丁基)，*未取代或取代的酰基，例如(C1—C4烷基)羰基，如乙酰基、丙酰基、丁酰基，苯乙酰基和氯乙酰基，*未取代或取代的芳基羰基，如苯甲酰基和2，4—二氯苯甲酰基，*未取代或取代的杂芳基羰基，如2—吡啶基羰基，*未取代或取代的芳基—(C1—C4)链烯基(如苯基—1—乙烯基、2—苯基—1—丙烯基、2，2—二苯基乙烯基、1—苯基—1—丙烯—2—基和1—苯基丁烯基)，*未取代或取代的芳氧基—(C1—C4)烷基，如苯氧甲基、苯氧乙基和苯氧丙基，*未取代或取代的杂芳基(如2—吡啶基、3—吡啶基、4—吡啶基、3—哒嗪基、4—哒嗪基、1—吡唑基、3—吡唑基、4—吡唑基、2—吡嗪基、2—嘧啶基、4—嘧啶基、5—嘧啶基、1—吲唑基、3—吲唑基、2—呋喃基、3—呋喃基、1—吡咯基、2—吡咯基、3—吡咯基、2—噻吩基、3—噻吩基、1—咪唑基、2—咪唑基、4—咪唑基、5—咪唑基、2—异吲哚基、1—吲哚基、1—吲唑基、1，2—苯并噻唑—3—基、1，3—苯并噻唑—2—基、3—异噁唑基、4—异噁唑基、5—异噁唑基、3—异噻唑基、4—异噻唑基、5—异噻唑基、1，2—苯并噁唑—3—基、1，3—苯并噁唑—2—基、1，2，4—三唑基、1，3，4—三唑基、7—purinyl、2—喹啉基、3—喹啉基、4—喹啉基、1—异喹啉基、3—异喹啉基、4—异喹啉基、2—苯并呋喃基、3—苯并呋喃基、1—异苯并呋喃基、1，2，4—三嗪—3—基和1，3，5—三嗪—2—基)，*未取代或取代的杂芳基—(C1—C4)烷基(如2—吡啶基甲基、3—吡啶基甲基)，*未取代或取代的杂芳基—(C2—C4)链烯基(如2’—呋喃基—2—乙烯基、2’—噻吩基—2—乙烯基、3’—吡啶基—2—乙烯基)，*未取代或取代的杂环基(如环氧乙烷基、1—氮杂环丙烷基、1—氮杂环丁烷基、1—吡咯烷基、2—四氢呋喃基、2—四氢吡喃基、3—四氢吡喃基、1—哌啶基、1—吗啉基、1—哌嗪基、1，3—二噁烷基、3—四氢噻喃基)。
除了氢原子外，上述“未取代的或取代的”所指的取代基例如为下列基团卤原子，如氟、氯、溴和碘原子；C1—C6烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基、1，1—二甲基乙基、戊基、1—甲基丁基、2—甲基丁基、3—甲基丁基、2，2—二甲基丙基、1—乙基丙基、己基、1，1—二甲基丙基、1，2—二甲基丙基、1—甲基戊基、2—甲基戊基、3—甲基戊基、4—甲基戊基、1，1—二甲基丁基、1，2—二甲基丁基、1，3—二甲基丁基、2，2—二甲基丁基、2，3—二甲基丁基、3，3—二甲基丁基、1—乙基丁基、2—乙基丁基、1，1，2—三甲基丙基、1，2，2—三甲基丙基、1—乙基—1—甲基丙基和1—乙基—2—甲基丙基；C1—C6烷氧基，如甲氧基、乙氧基、丙氧基、1—甲基乙氧基、丁氧基、1—甲基丙氧基、2—甲基丙氧基、1，1—二甲基乙氧基、戊氧基、1—甲基丁氧基、3—甲基丁氧基、1，1-甲基丙氧基、1，2-二甲基丙氧基、2，2—二甲基丙氧基、1—乙基丙氧基、己氧基、1—甲基戊氧基、2—甲基戊氧基、3—甲基戊氧基、4—甲基戊氧基、1，1—二甲基丁氧基、1，2—二甲基丁氧基、1，3—二甲基丁氧基、2，2—二甲基丁氧基、2，3—二甲基丁氧基、3，3—二甲基丁氧基、1—乙基丁氧基、2—乙基丁氧基、1，1，2—三甲基丙氧基、1，2，2—三甲基丙氧基、1—乙基—1—甲基丙氧基和1—乙基—2—甲基丙氧基；C1—C6烷硫基，如甲硫基、乙硫基、丙硫基、1—甲基乙硫基、丁硫基、1—甲基丙硫基、2—甲基丙硫基、1，1—二甲基乙硫基、戊硫基、1—甲基丁硫基、2—甲基丁硫基、3—甲基丁硫基、2，2—二甲基丙硫基、1—乙基丙硫基、己硫基、1，1—二甲基丙硫基、1，2—二甲基丙硫基、1—甲基戊硫基、2—甲基戊硫基、3—甲基戊硫基、4—甲基戊硫基、1，1—二甲基丁硫基、1，2—二甲基丁硫基、1，3—二甲基丁硫基、2，2—二甲基丁硫基、2，3—二甲基丁硫基、3，3—二甲基丁硫基、1—乙基丁硫基、2—乙基丁硫基、1，1，2—三甲基丙硫基、1，2，2—三甲基丙硫基、1—乙基—1—甲基丙硫基和1—乙基—2—甲基丙硫基；C2—C4卤代烷基、特别是C1—C2卤代烷基，如氯甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、三氟甲基、氯氟甲基、二氯一氟甲基、一氯二氟甲基、1—氟乙基、2—氟乙基、2，2—二氟乙基、2，2，2—三氟乙基、2—氯—2—氟乙基、2—氯—2，2—二氟乙基、2，2—二氯—2—氟乙基、2，2，2—三氯乙基和五氟乙基；C1—C4卤代烷氧基、特别是C1—C2卤代烷氧基，如氯甲氧基、二氯甲氧基、三氯甲氧基、氟甲氧基、二氟甲氧基、三氟甲氧基、氯氟甲氧基、二氯一氟甲氧基、一氯二氟甲氧基、1—氟乙氧基、2—氟乙氧基、2，2—二氟乙氧基、2，2，2—三氟乙氧基、2—氯—2—氟乙氧基、2—氯—2，2—二氟乙氧基、2，2—二氯—2—氟乙氧基、2，2，2—三氯乙氧基和五氟乙氧基；C2—C6链烯基氧基，如乙烯基氧基、1—丙烯基氧基、2—丙烯基氧基、1—甲基乙烯基氧基、1—丁烯基氧基、2—丁烯基氧基、3—丁烯基氧基、1—甲基—1—丙烯基氧基、2—甲基—1—丙烯基氧基、1—甲基—2—丙烯基氧基、2—甲基—2—丙烯基氧基、1—戊烯基氧基、2—戊烯基氧基、3—戊烯基氧基、4—戊烯基氧基、1—甲基—1—丁烯基氧基、2—甲基—1—丁烯基氧基、3—甲基—1—丁烯基氧基、1—甲基—2—丁烯基氧基、2—甲基—2—丁烯基氧基、3—甲基—2—丁烯基氧基、1—甲基—3—丁烯基氧基、2—甲基—3—丁烯基氧基、3—甲基—3—丁烯基氧基、1，1—二甲基—2—丙烯基氧基、1，2—二甲基—1—丙烯基氧基、1，2—二甲基—2—丙烯基氧基、1—乙基—1—丙烯基氧基、1—乙基—2—丙烯基氧基、1—己烯基氧基、2—己烯基氧基、3—己烯基氧基、4—己烯基氧基、5—己烯基氧基、1—甲基—1—戊烯基氧基、2—甲基—1—戊烯基氧基、3—甲基—1—戊烯基氧基、4—甲基—1—戊烯基氧基、1—甲基—2—戊烯基氧基、2—甲基—2—戊烯基氧基、3—甲基—2—戊烯基氧基、4—甲基—2—戊烯基氧基、1—甲基—3—戊烯基氧基、2—甲基—3—戊烯基氧基、3—甲基—3—戊烯基氧基、4—甲基—2—戊烯基氧基、1—甲基—4—戊烯基氧基、2—甲基—4—戊烯基氧基、3—甲基—4—戊烯基氧基、4—甲基—4—戊烯基氧基、1，1—二甲基—2—丁烯基氧基、1，1—二甲基—3—丁烯基氧基；氰基，氰氧基，氰硫基，硝基，氨基，羟基，羧基；二(C1—C6烷基)氨基、特别是二(C1—C4烷基)氨基，如N，N—二甲基氨基、N，N—二乙基氨基、N，N—二丙基氨基、N，N—二(1—甲基乙基)氨基、N，N—二丁基氨基、N，N—二(1—甲基丙基)氨基、N，N—二(2—甲基丙基)氨基、N，N—二(1，1—二甲基乙基)氨基、N—乙基—N—甲基—氨基、N—甲基—N—丙基氨基、N—甲基—N—(1—甲基乙基)氨基、N—丁基—N—甲基氨基、N—甲基—N—(1—甲基丙基)氨基、N—甲基—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—甲基氨基、N—乙基—N—丙基氨基、N—乙基—N—(1—甲基乙基)氨基、N—丁基—N—乙基氨基、N—乙基—N—(1—甲基丙基)氨基、N—乙基—N—(2—甲基丙基)氨基、N—(1—甲基丙基)—N—丙基氨基、N—(2—甲基丙基)—N—丙基氨基、N—(1，1—二甲基乙基)—N—丙基氨基、N—丁基—N—(1—甲基乙基)氨基、N—(1—甲基乙基)—N—(1—甲基丙基)氨基、N—(1—甲基乙基)—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—(1—甲基乙基)氨基、N—丁基—N—(1—甲基丙基)氨基、N—丁基—N—(2—甲基丙基)氨基、N—丁基—N—(1，1—二甲基乙基)氨基、N—(1—甲基丙基)—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—(1—甲基丙基)氨基和N—(1，1—二甲基乙基)—N—(2—甲基丙基)氨基；苯基、苯氧基、苯硫基和苯氨基，苯环上可带有1—5个如上所述的卤原子，和/或1—5个如上所述的C1—C6烷氧基，和/或1—5个如上所述的C1—C6烷硫基，和/或1—5个如上所述的C1—C4卤代烷基，和/或1—4个C1—C6烷氧亚氨基甲基(如甲氧亚氨基甲基、乙氧亚氨基甲基、正丙氧亚氨基甲基、正丁氧亚氨基甲基、正戊氧亚氨基甲基、正己氧亚氨基甲基、烯丙氧亚氨基甲基、苯甲氧亚氨基甲基、异丙氧亚氨基甲基、异丁氧亚氨基甲基和叔丁氧亚氨基甲基)，和/或1—4个C1—C6烷氧亚氨基乙基(如甲氧亚氨基乙基、乙氧亚氨基—1—乙基、正丙氧亚氨基—1—乙基、正丁氧亚氨基—1—乙基、正戊氧亚氨基—1—乙基、正己氧亚氨基—1—乙基、烯丙氧亚氨基—1—乙基、苯甲氧亚氨基—1—乙基)，和/或苯基、苯氧基及苯甲氧基，和/或C1—C4烷基亚氨基甲基(如甲基亚氨基甲基及乙基亚氨基甲基)，和/或1—4个C3—C6环烷基(如环丙基、环丁基、环戊基及环己基)。
在制备时，由于C＝C或C＝N双键的存在下，可得到式I所示新颖化合物的E/Z异构体混合物。用结晶结或色谱法可将它们拆分。它们的单个异构体及它们的混合物都在本发明范围内，都可用作杀真菌剂。
特别优选式中的取代基如下定义的式I化合物Y是氧原子或基团N—R6；Z1和Z2相互独立地为氢原子、甲基、甲氧基、氯原子、溴原子或三氟甲基；R1是氢原子、甲基或三氟甲基；R2是氢原子，或者未取代或取代的烷基、链烯基、链炔基、环烷基、芳基烷基、杂芳基烷基、芳氧基烷基或杂芳氧基烷基；以及R3、R4、R5和R6是氢原子、甲基或乙基。
此外，还优选式中的取代基如下定义的式I化合物Y是氧原子，Z1和Z2是氢原子，R3和R4是甲基，R5是氢原子；以及R1是氢原子或甲基；以及R1是氢原子、烷基、烯丙基、炔丙基、芳烷基、杂芳基烷基、芳氧基烷基或杂芳氧基烷基。
此外，还优选式中的R1是氢原子和R2是3—三氟甲基苯甲基的式I化合物。
还优选式中的R1是甲基和R2是3—三氟甲基苯甲基的式I化合物。
权利要求1所要求的式I化合物例如可按方案1所示路线制备(Z1和Z2表示氢原子)。
方案1
式I化合物例如可从式II所示酯(其制备公开于EP499 823中)、由II与氨或式III所示的胺反应制备。
式中的R4为H的式I化合物可由式IV所示羰基化合物(其中的R1＝H的制备参见EP393 428，R1不是氢的制备参见EP499823)与伯胺V反应，得到环状醛缩一胺VI，它与其醛或酮形式VII呈动态平衡，并以羰基化合物VII的形式与羟胺或肼的衍生物VIII或其酸加成盐反应，形成式I化合物(式中的R4＝烷基和R5＝H)。
式VI或VII中间体还可以从化合物X(方案2)(它可按已知方法由苯基乙醛酸酯与烷氧基胺盐酸盐和伯胺反应来制备)制备，首先将X二次金属化成XI，为此使用烷基金属如丁基锂(J.Org.Chem.29(1964)，853)或金属胺化物如二异丙胺化镁(EP418 013)；并使XI与羧酸衍生物XII(如羧酰氯、酸酐或酯)反应，或用醛XIII将XI转化成醇XIV、然后按已知方法氧化，制得羰基化合物VII(或其环状形式VI)。
方案2
式VIII(Y＝O)所示羟胺衍生物或是已知的，或可根据类似于Houben—Weyl X/1，pp.1192和1183的已知方法制备。
式VIII(Y＝NR6)所示肼衍生物或是已知的，或可根据类似于Houben—Weyl X/2，pp.271,280和740的已知方法制备。
胺(III和V)、苯基乙醛酸酯(IX)、羧酸衍生物(XII)和醛(XIII)是常见的已知化合物。
下列方法和实施例用于说明制备本发明的新颖活性化合物及其中间体的方法。
实施例11—羟基—2—甲基—4—甲氧亚氨基—1，2，3，4—四氢异喹啉—3—酮(方案1中的式VI化合物，R1＝H、R3＝R4＝CH3)的制备将11.0g(50mmol)式IV所示醛[(R1＝H，R3＝R7＝CH3)，其制备参见EP393 428)]溶于200ml THF中，并与10ml浓度为40％的甲胺(112mmol)水溶液一起在25℃搅拌30分钟。形成的化合物VI部分沉淀，将沉淀物抽滤分离，用醚洗涤并干燥。将母液浓缩又得到一些产品，用二异丙基醚处理残余物，抽滤。共得到9.0g无色晶体，产率82％，m.p.116—168℃。1H-NMR(CDCl3，D值)2.2-2.5(br，OH)，3.26(s，3H，NCH3)；4.06(s，3H，OCH3)；4.06(s，3H，OCH3)；5.71(s，1H，CH-OH)；7.2-7.5(m，3H)和8.41(dd，1H；芳烃质子)13C-NMR(CDCl3D值)33.o(q，NCH3)；64.0(q，OCH3)；82.6(d，HC-OH；125.0(s，C-C＝N)；127.6/128.7/130.2/130.6(4d，三级芳香C)；135.6(s，C-CHOH)；141.6(s，C＝N)；161.4(s，C＝O)IR(KBr，v in cm-1)3295，1648，1576，1021，765.
b)2—(O—3—溴苯甲基肟乙基)—α—甲氧亚氨基—N—甲基苯乙酰胺(表1中的化合物58)的制备半1.7g(7.7mmol)根据a)制备的醛缩一胺(VI)与2.3g(7.7mmol)3—溴苯甲氧基胺盐酸盐(VIII)(R2—Y＝3—BrC6H4CH2—O)一起在150ml THF中回流1小时。冷却后，反应混合物用饱和氯化钠溶液洗涤2次，用硫酸镁干燥，并浓缩。用环己烷/乙酸乙酯(90∶10—70∶30)作洗脱液，将残余油状物在硅胶上层析，并将油状产物用二异丙基醚结晶，得到1.1g近于无色的晶体，并率38％，m.p.103—105℃。1H-NMR(CDCl3，D值)2.88(d，3H，NCH3)；3.90(s，3H，OCH3)；5.10(s，2H，OCH2)；6.73(br 2，1H，NH)；7.1-7.8(m，8H，芳烃质于)7.94(s，1H，CH＝N－O).
实施例22—(O—3—甲基苯甲基肟甲基)—α—甲氧亚氨基—N—甲基苯乙酰胺(表1中的化合物36)的制备将13.6g(40mmol)2—(O—3—甲基苯甲基肟甲基)—α—甲氧亚氨基苯乙酸甲酯(其制备参见EP499 823)溶于100ml四氢呋喃中，向其中加入12ml浓度为40％的甲胺水溶液(150mmol CH3NH2)，并将该混合物在40℃搅拌7小时。
使其冷却至25℃，加入乙醚，使其分相，有机相用水洗涤，用硫酸钠干燥，并真空浓缩。得到13.0g黄色油状物，产率96％。
IR(γ，cm-1)1699，1527，1411，1035，980，785，756。
用与上述相同的方法，制备下列表中的活性化合物
表1 化合物编号.R2物化数据[M.p.(℃)；IR(cm-1)NMR(ppm)]1H2CH3M.p.98℃3CH3CH24CH3CH2CH25CH2＝CH-CH26CH2＝C(Cl)-CH2NMR(δ)＝2.94(d，3H)，3.97(s，3H)，4.68(s，2H)，5.43(d，2H)，6.8(s，1H)，7.2-8.0(m，5H)7CH3-CH＝CH-CH(CH3)8CH2＝C(CH3)-CH29HC＝C-CH210 CH3-O-CH2-CH211 C2H5-O-CH2-CH212 Cl-CH2-CH213 Cyclo-C3H5-CH214 CH3-CH＝CH-CH215 CH2＝CH-CH2-CH216 CH3-C≡C-CH217 CH3CH2-C≡C-CH218 CH3-(CH2)319 CH3-(CH2)420 (CH3)3CM.p.94℃21 环-C6H1122 2-CH3-环-C6H1023 C6H5-CH2M.p.116-119℃24 2-F-C6H4-CH225 3-F-C6H4-CH226 4-F-C6H4-CH227 2-Cl-C6H4-CH2
283-C1-C6H4-CH2IR1667，1527，1028，978，787，700294-Cl-C6H4-CH2M.p.142℃30 2，3-Cl2-C6H3-CH231 2，4-Cl2-C6H3-CH232 3，5-Cl2-C6H3-CH2M.p.92℃33 2，6-Cl2-C6H3-CH234 3，4-Cl2-C6H3-CH2NMR2.9(d，3H)，3.93(s，3H)，5.1(s，2H)，6.8(s，2H)and 7.2-8.0(m，3H)352-CH3-C6H4-CH2IR1667，1526，1036，980，747363-CH3-C6H4-CH2IR1669，1527，1411，1035，980，785，756374-CH3-C6H4-CH21661，1522，1492，1087，103538 2，3-(CH3)2-C6H3-CH239 2，4-(CH3)2-C6H3-CH240 2，5-(CH3)2-C6H3-CH241 3，4-(CH3)2-C6H3-CH242 3，5-(CH3)2-C6H3-CH243 4，5-(CH3)2-C6H3-CH244 2，3，4-(CH3)3-C6H2-CH245 2，4，5-(CH3)3-C6H2-CH246 2，4，6-(CH3)3-C6H2-CH247 2，3，6-(CH3)3-C6H2-CH2482-CF3-C6H4-CH2493-CF3-C5H4-CH2M.p.166-168℃504-CF3-C6H4-CH2512-CH3-3-CF3-C6H3-CH2522-CH3-4-CF3-C6H3-CH2532-CF3-3-CH3-C6H3-CH3542-CF3-4-CH3-C6H3-CH2552-CF3-5-CH3-C6H3-CH2562-CH3-5-CF3-C6H3-CH2572-Br-C6H4-CH2583-Br-C6H4-CH2M.p.103-105℃594-Br-C6H4-CH260 2-(异丙基)-C6H4-CH261 3-(异丙基)-C6H4-CH262 4-(异丙基)-C6H4-CH263 2-(异丙基)-3-Cl-C6H3-CH264 2-(异丙基)-4-Cl-C6H3-CH265 2-(异丙基)-5-Cl-C6H3-CH266 2-CH3-3-(异丙基)-C6H3-CH267 2-CH3-4-(异丙基)-C6H3-CH268 2-CH3-5-(异丙基)-C6H3-CH2692-t-C4H9-C6H4-CH2703-t-C4H9-C6H4-CH2714-t-C4H9-C6H4-CH2NMR1.91(s，9H)，2.9(d，3H)，3.90(s，3H)，5.15(s，2H)，6.7(s，1H)and 7.18-8.0(m，9H)722-CH3-3-t-C4H9-C6H3-CH2732-CH3-4-t-C4H9-C6H3-CH2742-CH3-5-t-C4H9-C6H3-CH2753-CH3-4-t-C4H9-C6H3-CH2763-CH3-5-t-C4H9-C6H3-CH2772-Cl-3-t-C4H9-C6H3-CH2782-Cl-4-t-C4H9-C6H3-CH2792-Cl-5-t-C4H9-C6H3-CH2803-Cl-4-t-C4H9-C6H3-H2813-Cl-5-t-C4H9-C6H3-CH2822-OCH3-C6H4-CH2833-OCH3-C6H4-CH2NMR2.8(d，3H)，3.80(s，3H)，3.9(s，3H)，5.75(s，2H)，6.7(s，1H)，6.8-8.0(m，9H)844-OCH3-C6H4-CH2852-CH3-3-OCH3-C6H3-CH2862-CH3-5-OCH3-C6H3-CH2873-CH3-4-OCH3-C6H3-CH2883-CH3-5-OCH3-C6H3-CH2892-Cl-3-OCH3-C6H3-CH2902-Cl-4-OCH3-C6H3-CH2912-Cl-5-OCH3-C6H3-CH2922-OCH3-3-Cl-C6H3-CH2932-OCH3-4-Cl-C6H3-CH2942-OCH3-5-Cl-C6H3-CH295 2-CH3-4-(环己基)-C6H3-CH2962-CH3-4-(C6H5-C6H3-CH2972-CH3-3-Br-C6H3-CH2982-CH3-4-Br-C6H3-CH2992-CH3-5-Br-C6H3-CH21002-CH3-3-(甲氧亚氨基甲基)-C6H3-CH21012-甲氧亚氨基甲基-C6H4-CH41023-甲氧亚氨基甲基-C6H4-CH41032-CH3-4-(甲氧亚氨基甲基)-C6H3-CH21042-苯基-C6H4-CH21053-苯基-C6H4-CH21064-苯基-C6H4-CH21072-苯氧基-C6H4-CH2108 3-苯氧基l-C6H4-CH2l09 4-苯氧基l-C6H4-CH2110 2-苄氧基ty-C6H4-CH2111 3-苄氧基ty-C6H4-CH2112 4-苄氧基ty-C6H4-CH2113 1-萘基yl-CH2114 2-萘基hyl-CH2IR1669，1526，1035，979，819，754115 9-蒽基-CH21162-CH3-3-C6H5O-C6H3-CH21172-CH3-4-C6H5O-C6H3-CH21182-CH3-5-C6H5O-C6H3-CH21193-CH3-4-C6H5O-C6H3-CH21204-CH3-5-C6H5O-C6H3-CH21212-Cl-3-C6H5O-C6H3-CH21222-Cl-4-C6H5O-C6H3-CH21232-Cl-5-C6H5O-C6H3-CH21243-Cl-4-C6H5O-C6H3-CH21253-Cl-5-C6H5OC6H3-CH21262-CH3-4-CO2CH3-C6H3-CH21272-CH3-4-CO2CH3-C6H3-CH2128C6H5-CH(CH3) M.p.105℃1292-F-C6H4-CH(CH3)1302-F-C6H4-CH(CH3)1314-F-C6H4-CH(CH3)1322-Cl-C6H4-CH(CH3)1333-Cl-C6H4-CH(CH3)1344-Cl-C6H4-CH(CH3) NMR1.58(d，3H)，2.9(d，3H)，3.8(s，3H)，5.22(q，1H)，6.69(s，1H)and 7.18-8.0(m，9H)135 2，3-Cl2-C6H3-CH(CH3)136 2，4-Cl2-C6H3-CH(CH3)137 2，5-Cl2-C6H3-CH(CH3)138 2，6-Cl2-C6H3-CH(CH3)139 3，4-Cl2-C6H3-CH(CH3)1402-CH3-C6H4-CH(CH3)1413-CH3-C6H4-CH(CH3)1424-CH3-C6H4-CH(CH3)143 2，3-(CH3)2-C6H3-CH(CH3)144 2，4-(CH3)2-C6H3-CH(CH3)145 2，5-(CH3)2-C6H3-CH(CH3) M.p.114℃146 3，4-(CH3)2-C6H3-CH(CH3)147 3，5-(CH3)2-C6H3-CH(CH3)148 4，5-(CH3)2-C6H3-CH(CH3)150 2，3，4-(CH3)3-C6H2-CH(CH3)151 2，4，5-(CH3)3-C6H2-CH(CH3)152 2，4，6-(CH3)3-C6H2-CH(CH3)153 2，2，6-(CH3)3-C6H2-CH(CH3)1542-CF3-C6H4-CH(CH3)1553-CF3-C6H4-CH(CH3) NMR1.6(d，3H)，2.9(d，3H)，3.85(s，3H)，5.3(q，1H)，6.8(s，1H)and 7.1-8.0(m，9H)1564-CF3-C6H4-CH(CH3)1572-CH3-3-CF3-C6H3-CH(CH3)1582-CH3-4-CF3-C6H3-CH(CH3)1592-CH3-3-CH3-C6H3-CH(CH3)1602-CH3-4-CH3-C6H3-CH(CH3)1612-CH3-5-CH3-C6H3-CH(CH3)1622-CH3-5-CF3-C6H3-CH(CH3)1632-Br-C6H4-CH(CH3)1643-Br-C6H4-CH(CH3)1654-Br-C6H4-CH(CH3)166 2-(异丙基)-C6H4-CH(CH3)167 3-(异丙基)-C6H4-CH(CH3)168 4-(异丙基)-C6H4-CH(CH3)169 2-(异丙基)-3-Cl-C6H3-CH(CH3)170 2-(异丙基)-4-Cl-C6H3-CH(CH3)171 2-(异丙基)-5-Cl-C6H3-CH(CH3)172 2-CH3-3-(异丙基)-C6H3-CH(CH3)173 2-CH3-4-(异丙基)-C6H3-CH(CH3)174 2-CH3-5-(异丙基)-C6H3-CH(CH3)1752-t-C4H9-C6H4-CH-(CH3)1763-t-C4H9-C6H4-CH-(CH3)1774-t-C4H9-C6H4-CH-(CH3)1782-CH3-3-t-C4H9-C6H3-CH(CH3)1792-CH3-4-t-C4H9-C6H3-CH(CH3)1802-CH3-5-t-C4H9-C6H3-CH(CH3)1813-CH3-4-t-C4H9-C6H3-CH(CH3)1823-CH3-5-t-C4H9-C6H3-CH(CH3)1832-Cl-3-t-C4H9-C6H3-CH(CH3)1842-Cl-4-t-C4H9-C6H3-CH(CH3)1853-Cl-4-t-C4H9-C6H3-CH(CH3)1873-Cl-5-t-C4H9-C6H3-CH(CH3)1882-OCH3-C6H4-CH2-CH(CH3)1893-OCH3-C6H4-CH2-CH(CH3)1904-OCH3-C6H4-CH2-CH(CH3)1912-CH3-3-OCH3-C6H3-CH(CH3)1922-CH3-4-OCH3-C6H3-CH(CH3)1932-CH3-5-OCH3-C6H3-CH(CH3)1943-CH3-5-OCH3-C6H3-CH(CH3)1953-CH3-5-OCH3-C6H3-CH(CH3)1962-Cl-3-OCH3-C6H3-CH(CH3)1972-Cl-4-OCH3-C6H3-CH(CH3)1982-Cl-5-OCH3-C6H3-CH(CH3)1992-OCH3-3-Cl-C6H3-CH(CH3)2002-OCH3-4-Cl-C6H3-CH(CH3)2012-OCH3-5-Cl-C6H3-CH(CH3)202 2-CH3-4-(环己基)-C6H3-CH(CH3)2032-CH3-4-C6H5-C6H3-CH(CH3)2042-CH3-3-Br-C6H3-CH(CH3)2052-CH3-4-Br-C6H3-CH(CH3)2063-CH3-5-Br-C6H3-CH(CH3)207 2-CH3-3-(甲氧亚氨基甲基)-C6H3-CH(CH3)208 2-甲氧亚氨基甲基-C6H4-CH(CH3)209 3-甲氧亚氨基甲基-C6H4-CH(CH3)210 2-CH3-4-(甲氧亚氨基甲基)-C6H3-CH(CH3)211 2-苯基-C6H4-CH(CH3)212 3-苯基1-C6H4-CH(CH3)213 4-苯基1-C6H4-CH(CH3)214 2-苯氧基-C6H4-CH(CH3)215 3-苯氧基-C6H4-CH(CH3)216 4-苯氧基-C6H4-CH(CH3)217 2-苄氧基-C6H4-CH(CH3)218 3-苄氧基-C6H4-CH(CH3)219 4-苄氧基-C6H4-CH(CH3)220 1-萘基-CH(CH3)221 2-萘基-CH(CH3)222 9-蒽基-CH(CH3)2232-CH3-3-C6H5O-C6H3-CH(CH3)2242-CH3-4-C6H5O-C6H3-CH(CH3)2252-CH3-5-C6H5O-C6H3-CH(CH3)2263-CH3-4-C6H5O-C6H3-CH(CH3)2274-CH3-5-C6H5O-C6H3-CH(CH3)2282-Cl-3-C6H5O-C6H3-CH(CH3)2292-Cl-4-C6H5O-C6H3-CH(CH3)2302-Cl-5-C6H5O-C6H3-CH(CH3)2313-Cl-4-C6H5O-C6H3-CH(CH3)2323-Cl-5-C6H5O-C6H3-CH(CH3)2332-CH3-4-CO2CH3-C6H3-CH(CH3)2342-CH3-5-CO2CH3-C6H3-CH(CH3)235C6H5-(CH2)22362-F-C6H4-(CH2)22373-F-C6H4-(CH2)22384-F-C6H4-(CH2)22392-Cl-C6H4-(CH2)22403-Cl-C6H4-(CH2)22414-Cl-C6H4-(CH2)2242 2，3-Cl2-C6H3-(CH2)2243 2，4-Cl2-C6H3-(CH2)2244 2，5-Cl2-C6H3-(CH2)2245 2，6-Cl2-C6H3-(CH2)2246 3，4-Cl2-C6H3-(CH2)22472-CH3-C6H4-(CH2)22483-CH3-C6H4-(CH2)22494-CH3-C6H4-(CH2)2250 2，3-(CH3)2-C6H3-(CH2)2251 2，3-(CH3)2-C6H3-(CH2)2252 2，5-(CH3)2-C6H3-(CH2)2253 3，4-(CH3)2-C6H3-(CH2)2254 3，5-(CH3)2-C6H3-(CH2)2255 4，5-(CH3)2-C6H3-(CH2)2256 2，3，4-(CH3)3-C6H2-(CH2)2257 2，4，5-(CH3)3-C6H2-(CH2)2258 2，4，6-(CH3)3-C6H2-(CH2)2259 2，2，6-(CH3)3-C6H2-(CH2)22602-CF3-C6H4-(CH2)22612-CF3-C6H4-(CH2)22624-CF3-C6H4-(CH2)22632-CH3-3-CF3-C6H3-(CH2)22642-CH3-4-CF3-C6H3-(CH2)22652-CF3-3-CH3-C6H3-(CH2)22662-CF3-4-CH3-C6H3-(CH2)22672-CF3-5-CH3-C6H3-(CH2)22682-CH3-3-CH3-C6H3-(CH2)22692-Br-C6H4-(CH2)22703-Br-C6H4-(CH2)22714-Br-C6H4-(CH2)2272 2-(异丙基)-C6H4-(CH2)2273 3-(异丙基)-C6H4-(CH2)2274 4-(异丙基)-C6H4-(CH2)2275 2-(异丙基)-3-Cl-C6H3-(CH2)2276 2-(异丙基)-4-Cl-C6H3-(CH2)2277 2-(异丙基)-5-Cl-C6H3-(CH2)2278 2-CH3-3-(异丙基)-C6H3-(CH2)2279 2-CH3-4-(异丙基)-C6H3-(CH2)2280 2-CH3-5-(异丙基)-C6H3-(CH2)22812-t-C4H9-C6H4-(CH2)22823-t-C4H9-C6H4-(CH2)22834-t-C4H9-C6H4-(CH2)22842-CH3-3-t-C4H9-C6H3-(CH2)22852-CH3-4-t-C4H9-C6H3-(CH2)22862-CH3-5-t-C4H9-C6H3-(CH2)22873-CH3-4-t-C4H9-C6H3-(CH2)22883-CH3-5-t-C4H9-C6H3-(CH2)22892-Cl-3-t-C4H9-C6H3-(CH2)22902-Cl-4-t-C4H9-C6H3-(CH2)22912-Cl-5-t-C4H9-C6H3-(CH2)22923-Cl-4-t-C4H9-C6H3-(CH2)22933-Cl-5-t-C4H9-C6H3-(CH2)22942-OCH3-C6H4-(CH2)22953-OCH3-C6H4-(CH2)22964-OCH3-C6H4-(CH2)22972-CH3-3-OCH3-C6H3-(CH2)22982-CH3-4-OCH3-C6H3-(CH2)22992-CH3-5-OCH3-C6H3-(CH2)23003-CH3-4-OCH3-C6H3-(CH2)23013-CH3-5-OCH3-C6H3-(CH2)23022-Cl-3-OCH3-C6H3-(CH3)23032-Cl-4-OCH3-C6H3-(CH3)23042-Cl-5-OCH3-C6H3-(CH3)23052-OCH3-3-Cl-C6H3-(CH3)23062-OCH3-4-Cl-C6H3-(CH3)23072-OCH3-5-Cl-C6H3-(CH3)2308 2-CH3-4-(环己基)-C6H3-(CH2)23092-CH3-4-C6H5-C6H3-(CH2)23102-CH3-3-Br-C6H3-(CH2)23112-CH3-4-Br-C6H3-(CH2)23122-CH3-5-Br-C6H3-(CH2)2313 2-CH3-3-(甲氧亚氨基甲基)-C6H3-(CH2)2314 2-甲氧亚氨基甲基-C6H4-(CH2)2315 3-甲氧亚氨基甲基-C6H4-(CH2)2316 2-CH3-4-(甲氧亚氨基甲基)-C6H3-(CH2)2317 2-苯基-C6H4-(CH2)2318 3-苯基-C6H4-(CH2)2319 4-苯基-C6H4-(CH2)2320 2-苯氧基-C6H4-(CH2)2321 3-苯氧基-C6H4-(CH2)2322 4-苯氧基-C6H4-(CH2)2323 2-苄氧基-C6H4-(CH2)2324 2-苄氧基-C6H4-(CH2)2325 4-苄氧基-C6H4-(CH2)2326 1-萘基-(CH2)2327 2-萘基-(CH2)2328 9-蒽基-(CH2)23292-CH3-3-C6H5O-C6H3-(CH2)23302-CH3-4-C6H5O-C6H3-(CH2)23312-CH3-5-C6H5O-C6H3-(CH2)23323-CH3-4-C6H5O-C6H3-(CH2)23334-CH3-5-C6H5O-C6H3-(CH2)23342-Cl-3-C6H5O-C6H3-(CH2)23352-Cl-4-C6H5O-C6H3-(CH2)23362-Cl-5-C6H5O-C6H3-(CH2)23373-Cl-4-C6H5O-C6H3-(CH2)23383-Cl-5-C6H5O-C6H3-(CH2)23392-CH3-4-CO2CH3-C6H3-(CH2)23402-CH3-5-CO2CH3-C6H3-(CH2)2341C6H5-CH＝CH-CH23422-F-C6H4-CH＝CH-CH23432-F-C6H4-CH＝CH-CH23444-F-C6H4-CH＝CH-CH23452-Cl-C6H4-CH＝CH-CH23463-Cl-C6H4-CH＝CH-CH23474-Cl-C6H4-CH＝CH-CH2348 2，3-Cl2-C6H3-CH＝CH-CH2349 2，4-Cl2-C6H3-CH＝CH-CH2350 2，5-Cl2-C6H3-CH＝CH-CH2351 2，6-Cl2-C6H3-CH＝CH-CH2352 3，4-Cl2-C6H3-CH＝CH-CH23532-CH3-C6H4-CH＝CH-CH23543-CH3-C6H4-CH＝CH-CH23554-CH3-C6H4-CH＝CH-CH2356 2，3-(CH3)2-C6H3-CH＝CH-CH2357 2，4-(CH3)2-C6H3-CH＝CH-CH2358 2，5-(CH3)2-C6H3-CH＝CH-CH2359 3，4-(CH3)2-C6H3-CH＝CH-CH2360 3，5-(CH3)2-C6H3-CH＝CH-CH2361 4，5-(CH3)2-C6H3-CH＝CH-CH2362 2，3，4-(CH3)3-C6H2-CH＝CH-CH2363 2，4，5-(CH3)3-C6H2-CH＝CH-CH2364 2，4，6-(CH3)3-C6H2-CH＝CH-CH2365 2，3，6-(CH3)3-C6H2-CH＝CH-CH23662-CF3-C6H4-CH＝CH-CH23673-CF3-C6H4-CH＝CH-CH23684-CF3-C6H4-CH＝CH-CH23692-CH3-3-CF3-C6H3-CH＝CH-CH23702-CH3-4-CF3-C6H3-CH＝CH-CH23712-CF3-3-CF3-C6H3-CH＝CH-CH23722-CF3-4-CF3-C6H3-CH＝CH-CH23732-CF3-5-CF3-C6H3-CH＝CH-CH23742-CH3-5-CF3-C6H3-CH＝CH-CH2375C6H5-(CH2)3376C6H5-(CH2)4377C6H5-CH2CH＝CH-CH23784-F-C6H4-CH＝CH-(CH2)2379CH3O-CO-CH2380CH3CH2O-CO-CO2381CH3-CO-CH2-CH2382t-C4H9O-CO-CH2383t-C4H9O-CO-(CH2)2384t-C4H9O-CO-CH(CH3) NMR1.42(d，9H)，1.5(s，9H)，2.96(d，3H)，3.97(s，3H)，4.62(q，9H)，6.87(s，1H)，7.18-8.0(m，9H)385n-C4H9O-CO-CH2386 异-C4H9O-CO-CH2387n-C3H7O-CO-CH2388 仲-C4H9O-COCH2389C6H5-CO-CH23902-CH3-C6H4C-CO-CH23913-CH3-C6H4C-CO-CH23924-CH3-C6H4C-CO-CH23932-Cl-C6H4O-CO-CH23943-Cl-C6H4O-CO-CH23954-Cl-C6H4-CO-CH2396C6H5-C(CH3)＝CH-CH2IR1662，1527，1445，1035，987，757397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452M.p.95-97℃453 454 455 456 457 458 459 460 461 462N≡C-CH2463t-BuO-CH2-CH＝CH-CH2464(CH3)2-C＝CH-CH2-CH2-C(CH3)＝CH-CH2465(CH3)2CH-C＝CH-CH2-CH2-C(CH3)＝CH-CH2466C6H5-O-CH(CH3)-CH24674-Cl-C6H4-C-CH(CH3)-CH2NMR1.3(d，3H)，2.9(d，3H)，3.9(s，3H)，4.1-4.35(m，2H)，4.65(m，1H)，6.8-7.9(m，10H)
表2 化合物编号 R21 H2 CH33 CH3CH24 CH3CH2CH25 CH2＝CH-CH26 CH2＝C(Cl)-CH27 CH3-CH＝CH-CH(CH3)8 CH2＝C(CH3)-CH29 HC＝C-CH210 CH3-O-CH2-CH211 C2H5-O-CH2-CH212 Cl-CH2-CH213 Cyclo-C3H5-CH214 CH3-CH＝CH-CH215 CH2＝CH-CH2-CH216 CH3-C≡C-CH217 CH3CH2-C≡C-CH218 CH3-(CH2)319 CH3-(CH2)420 (CH3)3C21 环-C6H1122 2-CH3-环-C6H1023 C6H5-CH224 2-F-C6H4-CH225 3-F-C6H4-CH226 4-F-C6H4-CH227 2-Cl-C6H4-CH228 3-Cl-C6H4-CH229 4-Cl-C6H4-CH230 2，3-Cl2-C6H3-CH231 2，4-Cl2-C6H3-CH232 3，5-Cl2-C6H3-CH233 2，6-Cl2-C6H3-CH234 3，4-Cl2-C6H3-CH235 2-CH3-C6H4-CH2374-CH3-C6H4-CH238 2，3-(CH3)2-C6H3-CH239 2，4-(CH3)2-C6H3-CH240 2，5-(CH3)2-C6H3-CH241 3，4-(CH3)2-C6H3-CH242 3，5-(CH3)2-C6H3-CH243 4，5-(CH3)2-C6H3-CH244 2，3，4-(CH3)3-C6H2-CH245 2，4，5-(CH3)3-C6H2-CH246 2，4，6-(CH3)3-C6H2-CH247 2，3，6-(CH3)3-C6H2-CH2482-CF3-C6H4-CH2493-CF3-C6H4-CH2504-CF3-C6H4-CH2512-CH3-3-CF3-C6H3-CH2522-CH3-4-CF3-C6H3-CH2532-CF3-3-CH3-C6H3-CH3542-CF3-4-CH3-C6H3-CH2552-CF3-5-CH3-C6H3-CH2562-CH3-5-CF3-C6H3-CH2572-Br-C6H4-CH2583-Br-C6H4-CH2594-Br-C6H4-CH260 2-(异丙基pyl)-C6H4-CH261 3-(异丙基yl)-C6H4-CH262 4-(异丙基yl)-C6H4-CH263 2-(异丙基yl)-3-Cl-C6H3-CH264 2-(异丙基yl)-4-Cl-C6H3-CH265 2-(异丙基yl)-5-Cl-C6H3-CH266 2-CH3-3-(异丙基yl)-C6H3-CH267 2-CH3-4-(异丙基yl)-C6H3-CH268 2-CH3-5-(异丙基yl)-C6H3-CH2692-t-C4H9-C6H4-CH2703-t-C4H9-C6H4-CH2714-t-C4H9-C6H4-CH2722-CH3-3-t-C4H9-C6H3-CH2732-CH3-4-t-C4H9-C6H3-CH2742-CH3-5-t-C4H9-C6H3-CH2753-CH3-4-t-C4H9-C6H3-CH2763-CH3-5-t-C4H9-C6H3-CH2772-Cl-3-t-C4H9-C6H3-CH2782-Cl-4-t-C4H9-C6H3-CH2792-Cl-5-t-C4H9-C6H3-CH2803-Cl-4-t-C4H9-C6H3-H2813-Cl-5-t-C4H9-C6H3-CH2822-OCH3-C6H4-CH2833-OCH3-C6H4-CH2844-OCH3-C6H4-CH2852-CH3-3-OCH3-C6H3-CH2862-CH3-5-OCH3-C6H3-CH2873-CH3-4-OCH3-C6H3-CH2883-CH3-5-OCH3-C6H3-CH2892-Cl-3-OCH3-C6H3-CH2902-Cl-4-OCH3-C6H3-CH2912-Cl-5-OCH3-C6H3-CH2922-OCH3-3-Cl-C6H3-CH2932-OCH3-4-Cl-C6H3-CH2942-OCH3-5-Cl-C6H3-CH295 2-CH3-4-(环己基)-C6H3-CH2962-CH3-4-(C6H5-C6H3-CH2972-CH3-3-Br-C6H3-CH2982-CH3-4-Br-C6H3-CH2992-CH3-5-Br-C6H3-CH21002-CH3-3-(甲氧亚氨基甲基)-C6H3-CH21012-(甲氧亚氨基甲基)-C6H4-CH41023-(甲氧亚氨基甲基)-C6H4-CH41032-CH3-4-(甲氧亚氨基甲基)-C6H3-CH21042-苯基-C6H4-CH21053-苯基-C6H4-CH21064-苯基-C6H4-CH21072-苯氧基-C6H4-CH21083-苯氧基-C6H4-CH21094-苯氧基-C6H4-CH21102-苄氧基-C6H4-CH21113-苄氧基-C6H4-CH21124-苄氧基-C6H4-CH21131-萘基-CH21142-萘基-CH21159-蒽基-CH2116 2-CH3-3-C6H5O-C6H3-CH2117 2-CH3-4-C6H5O-C6H3-CH2118 2-CH3-5-C6H5O-C6H3-CH2119 3-CH3-4-C6H5O-C6H3-CH2120 4-CH3-5-C6H5O-C6H3-CH2121 2-Cl-3-C6H5O-C6H3-CH2122 2-C1-4-C6H5O-C6H3-CH2123 2-Cl-5-C6H5O-C6H3-CH2124 3-Cl-4-C6H5O-C6H3-CH2125 3-Cl-5-C6H5OC6H3-CH2126 2-CH3-4-CO2CH3-C6H3-CH2127 2-CH3-4-CO2CH3-C6H3-CH2128 C6H5-CH(CH3)129 2-F-C6H4-CH(CH3)130 2-F-C6H4-CH(CH3)1314-F-C6H4-CH(CH3)1322-Cl-C6H4-CH(CH3)1333-Cl-C6H4-CH(CH3)1344-Cl-C6H4-CH(CH3)135 2，3-Cl2-C6H3-CH(CH3)136 2，4-Cl2-C6H3-CH(CH3)137 2，5-Cl2-C6H3-CH(CH3)138 2，6-Cl2-C6H3-CH(CH3)139 3，4-Cl2-C6H3-CH(CH3)1402-CH3-C6H4-CH(CH3)1413-CH3-C6H4-CH(CH3)1424-CH3-C6H4-CH(CH3)143 2，3-(CH3)2-C6H3-CH(CH3)144 2，4-(CH3)2-C6H3-CH(CH3)145 2，5-(CH3)2-C6H3-CH(CH3)146 3，4-(CH3)2-C6H3-CH(CH3)147 3，5-(CH3)2-C6H3-CH(CH3)148 4，5-(CH3)2-C6H3-CH(CH3)150 2，3，4-(CH3)3-C6H2-CH(CH3)151 2，4，5-(CH3)3-C6H2-CH(CH3)152 2，4，6-(CH3)3-C6H2-CH(CH3)153 2，2，6-(CH3)3-C6H2-CH(CH3)1542-CF3-C6H4-CH(CH3)1553-CF3-C6H4-CH(CH3)1564-CF3-C6H4-CH(CH3)1572-CH3-3-CF3-C6H3-CH(CH3)1582-CH3-4-CF3-C6H3-CH(CH3)1592-CH3-3-CH3-C6H3-CH(CH3)1602-CH3-4-CH3-C6H3-CH(CH3)1612-CH3-5-CH3-C6H3-CH(CH3)1622-CH3-5-CF3-C6H3-CH(CH3)1632-Br-C5H4-CH(CH3)1643-Br-C6H4-CH(CH3)1654-Br-C6H4-CH(CH3)166 2-(异丙基)-C6H4-CH(CH3)167 3-(异丙基)-C6H4-CH(CH3)168 4-(异丙基)-C6H4-CH(CH3)169 2-(异丙基)-3-Cl-C6H3-CH(CH3)170 2-(异丙基)-4-Cl-C6H3-CH(CH3)171 2-(异丙基)-5-Cl-C6H3-CH(CH3)172 2-CH3-3-(异丙基)-C6H3-CH(CH3)173 2-CH3-4-(异丙基)-C6H3-CH(CH3)174 2-CH3-5-(异丙基)-C6H3-CH(CH3)1752-t-C4H9-C6H4-CH-(CH3)1763-t-C4H9-C6H4-CH-(CH3)1774-t-C4H9-C6H4-CH-(CH3)1782-CH3-3-t-C4H9-C6H3-CH(CH3)1792-CH3-4-t-C4H9-C6H3-CH(CH3)1802-CH3-5-t-C4H9-C6H3-CH(CH3)1813-CH3-4-t-C4H9-C6H3-CH(CH3)1823-CH3-5-t-C4H9-C6H3-CH(CH3)1832-Cl-3-t-C4H9-C6H3-CH(CH3)1842-Cl-4-t-C4H9-C6H3-CH(CH3)1853-Cl-4-t-C4H9-C6H3-CH(CH3)1873-Cl-5-t-C4H9-C6H3-CH(CH3)1882-OCH3-C6H4-CH2-CH(CH3)1893-OCH3-C6H4-CH2-CH(CH3)1904-OCH3-C6H4-CH2-CH(CH3)1912-CH3-3-OCH3-C6H3-CH(CH3)1922-CH3-4-OCH3-C6H3-CH(CH3)1932-CH3-5-OCH3-C6H3-CH(CH3)1943-CH3-5-OCH3-C6H3-CH(CH3)1953-CH3-5-OCH3-C6H3-CH(CH3)1962-Cl-3-OCH3-C6H3-CH(CH3)1972-Cl-4-OCH3-C6H3-CH(CH3)1982-Cl-5-OCH3-C6H3-CH(CH3)1992-OCH3-3-Cl-C6H3-CH(CH3)2002-OCH3-4-Cl-C6H3-CH(CH3)2012-OCH3-5-Cl-C6H3-CH(CH3)202 2-CH3-4-(环己基)-C6H3-CH(CH3)2032-CH3-4-C6H5-C6H3-CH(CH3)2042-CH3-3-Br-C6H3-CH(CH3)2052-CH3-4-Br-C6H3-CH(CH3)2063-CH3-5-Br-C6H3-CH(CH3)207 2-CH3-3-(甲氧亚氨基甲基)-C6H3-CH(CH3)208 2-甲氧亚氨基甲基-C6H4-CH(CH3)209 3-甲氧亚氨基甲基-C6H4-CH(CH3)210 2-CH3-4-(甲氧亚氨基甲基)-C6H3-CH(CH3)211 2-苯基-C6H4-CH(CH3)212 3-苯基-C6H4-CH(CH3)213 4-苯基-C6H4-CH(CH3)214 2-苯氧基-C6H4-CH(CH3)215 3-苯氧基-C6H4-CH(CH3)216 4-苯氧基-C6H4-CH(CH3)217 2-苄氧基-C6H4-CH(CH3)218 3-苄氧基-C6H4-CH(CH3)219 4-苄氧基-C6H4-CH(CH3)220 1-萘基-CH(CH3)221 2-萘基-CH(CH3)222 9-蒽基-CH(CH3)2232-CH3-3-C6H5O-C6H3-CH(CH3)2242-CH3-4-C6H5O-C6H3-CH(CH3)2252-CH3-5-C6H5O-C6H3-CH(CH3)2263-CH3-4-C6H5O-C6H3-CH(CH3)2274-CH3-5-C6H5O-C6H3-CH(CH3)2282-Cl-3-C6H5O-C6H3-CH(CH3)2292-Cl-4-C6H5O-C6H3-CH(CH3)2302-Cl-5-C6H5O-C6H3-CH(CH3)2313-Cl-4-C6H5O-C6H3-CH(CH3)2323-Cl-5-C6H5O-C6H3-CH(CH3)2332-CH3-4-CO2CH3-C6H3-CH(CH3)2342-CH3-5-CO2CH3-C6H3-CH(CH3)235C6H5-(CH2)22362-F-C6H4-(CH2)22373-F-C6H4-(CH2)22384-F-C6H4-(CH2)22392-Cl-C6H4-(CH2)22403-Cl-C6H4-(CH2)22414-Cl-C6H4-(CH2)2242 2，3-Cl2-C6H3-(CH2)2243 2，4-Cl2-C6H3-(CH2)2244 2，5-Cl2-C6H3-(CH2)2245 2，6-Cl2-C6H3-(CH2)2246 3，4-Cl2-C6H3-(CH2)22472-CH3-C6H4-(CH2)22483-CH3-C6H4-(CH2)22494-CH3-C6H4-(CH2)2250 2，3-(CH3)2-C6H3-(CH2)2251 2，3-(CH3)2-C6H3-(CH2)2252 2，5-(CH3)2-C6H3-(CH2)2253 3，4-(CH3)2-C6H3-(CH2)2254 3，5-(CH3)2-C6H3-(CH2)2255 4，5-(CH3)2-C6H3-(CH2)2256 2，3，4-(CH3)3-C6H2-(CH2)2257 2，4，5-(CH3)3-C6H2-(CH2)2258 2，4，6-(CH3)3-C6H2-(CH2)2259 2，2，6-(CH3)3-C6H2-(CH2)22602-CF3-C6H4-(CH2)22612-CF3-C6H4-(CH2)22624-CF3-C6H4-(CH2)22632-CH3-3-CF3-C6H3-(CH2)22642-CH3-4-CF3-C6H3-(CH2)22652-CF3-3-CH3-C6H3-(CH2)22662-CF3-4-CH3-C6H3-(CH2)22672-CF3-5-CH3-C6H3-(CH2)22682-CH3-3-CH3-C6H3-(CH2)22692-Br-C6H4-(CH2)22703-Br-C6H4-(CH2)22714-Br-C6H4-(CH2)2272 2-(异丙基)-C6H4-(CH2)2273 3-(异丙基)-C6H4-(CH2)2274 4-(异丙基)-C6H4-(CH2)2275 2-(异丙基)-3-Cl-C6H3-(CH2)2276 2-(异丙基)-4-Cl-C6H3-(CH2)2277 2-(异丙基)-5-Cl-C6H3-(CH2)2278 2-CH3-3-(异丙基)-C6H3-(CH2)2279 2-CH3-4-(异丙基)-C6H3-(CH2)2280 2-CH3-5-(异丙基)-C6H3-(CH2)22812-t-C4H9-C6H4-(CH2)22823-t-C4H9-C6H4-(CH2)22834-t-C4H9-C6H4-(CH2)22842-CH3-3-t-C4H9-C6H3-(CH2)22852-CH3-4-t-C4H9-C6H3-(CH2)22862-CH3-5-t-C4H9-C6H3-(CH2)22873-CH3-4-t-C4H9-C6H3-(CH2)22883-CH3-5-t-C4H9-C6H3-(CH2)22892-Cl-3-t-C4H9-C6H3-(CH2)22902-Cl-4-t-C4H9-C6H3-(CH2)22912-Cl-5-t-C4H9-C6H3-(CH2)22923-Cl-4-t-C4H9-C6H3-(CH2)22933-Cl-5-t-C4H9-C6H3-(CH2)22942-OCH3-C6H4-(CH2)22953-OCH3-C6H4-(CH2)22964-OCH3-C6H4-(CH2)22972-CH3-3-OCH3-C6H3-(CH2)22982-CH3-4-OCH3-C6H3-(CH2)22992-CH3-5-OCH3-C6H3-(CH2)23003-CH3-4-OCH3-C6H3-(CH2)23013-CH3-5-OCH3-C6H3-(CH2)23022-Cl-3-OCH3-C6H3-(CH3)23032-Cl-4-OCH3-C6H3-(CH3)23042-Cl-5-OCH3-C6H3-(CH3)23052-OCH3-3-Cl-C6H3-(CH3)23062-OCH3-4-Cl-C6H3-(CH3)23072-OCH3-5-Cl-C6H3-(CH3)2308 2-CH3-4-(环己基)-C6H3-(CH2)23092-CH3-4-C6H5-C6H3-(CH2)23102-CH3-3-Br-C6H3-(CH2)23112-CH3-4-Br-C6H3-(CH2)23122-CH3-5-Br-C6H3-(CH2)2313 2-CH3-3-(甲氧亚氨基甲基)-C6H3-(CH2)2314 2-(甲氧亚氨基甲基)-C6H4-(CH2)2315 3-(甲氧亚氨基甲基)-C6H4-(CH2)2316 2-CH3-4-(甲氧亚氨基甲基)-C6H3-(CH2)2317 2-苯基-C6H4-(CH2)2318 3-苯基-C6H4-(CH2)2319 4-苯基-C6H4-(CH2)2320 2-苯氧基-C6H4-(CH2)2321 3-苯氧基-C6H4-(CH2)2322 4-苯氧基-C6H4-(CH2)2323 2-苄氧基-C6H4-(CH2)2324 2-苄氧基-C6H4-(CH2)2325 4-苄氧基-C6H4-(CH2)2326 1-萘基-(CH2)2327 2-萘基-(CH2)2328 9-蒽基-(CH2)23292-CH3-3-C6H5O-C6H3-(CH2)23302-CH3-4-C6H5O-C6H3-(CH2)23312-CH3-5-C6H5O-C6H3-(CH2)23323-CH3-4-C6H5O-C6H3-(CH2)23334-CH3-5-C6H5O-C6H3-(CH2)23342-Cl-3-C6H5O-C6H3-(CH2)23352-Cl-4-C6H5O-C6H3-(CH2)23362-Cl-5-C6H5O-C6H3-(CH2)23373-Cl-4-C6H5O-C6H3-(CH2)23383-Cl-5-C6H5O-C6H3-(CH2)23392-CH3-4-CO2CH3-C6H3-(CH2)23402-CH3-5-CO2CH3-C6H3-(CH2)2341C6H5-CH＝CH-CH23422-F-C6H4-CH＝CH-CH23432-F-C6H4-CH＝CH-CH23444-F-C6H4-CH＝CH-CH23452-Cl-C6H4-CH＝CH-CH23463-Cl-C6H4-CH＝CH-CH23474-Cl-C6H4-CH＝CH-CH2348 2，3-Cl2-C6H3-CH＝CH-CH2349 2，4-Cl2-C6H3-CH＝CH-CH2350 2，5-Cl2-C6H3-CH＝CH-CH2351 2，6-C12-C6H3-CH＝CH-CH2352 3，4-Cl2-C6H3-CH＝CH-CH23532-CH3-C6H4-CH＝CH-CH23543-CH3-C6H4-CH＝CH-CH23554-CH3-C6H4-CH＝CH-CH2356 2，3-(CH3)2-C6H3-CH＝CH-CH2357 2，4-(CH3)2-C6H3-CH＝CH-CH2358 2，5-(CH3)2-C6H3-CH＝CH-CH2359 3，4-(CH3)2-C6H3-CH＝CH-CH2360 3，5-(CH3)2-C6H3-CH＝CH-CH2361 4，5-(CH3)2-C6H3-CH＝CH-CH2362 2，3，4-(CH3)3-C6H2-CH＝CH-CH2363 2，4，5-(CH3)3-C6H2-CH＝CH-CH2364 2，4，6-(CH3)3-C6H2-CH＝CH-CH2365 2，3，6-(CH3)3-C6H2-CH＝CH-CH23662-CF3-C6H4-CH＝CH-CH23673-CF3-C6H4-CH＝CH-CH23684-CF3-C6H4-CH＝CH-CH23692-CH3-3-CF3-C6H3-CH＝CH-CH23702-CH3-4-CF3-C6H3-CH＝CH-CH23712-CF3-3-CF3-C6H3-CH＝CH-CH23722-CF3-4-CF3-C6H3-CH＝CH-CH23732-CF3-5-CF3-C6H3-CH＝CH-CH23742-CH3-5-CF3-C6H3-CH＝CH-CH2375C6H5-(CH2)3376C6H5-(CH2)4377C6H5-CH2CH＝CH-CH23784-F-C6H4-CH＝CH-(CH2)2379CH3O-CO-CH2380CH3CH2O-CO-CO2381CH3-CO-CH2-CH2382t-C4H9O-Co-CH2383t-C4H9O-CO-(CH2)2384t-C4H9O-CO-CH(CH3)385n-C4H9O-CO-CH2386 异-C4H9O-CO-CH2387n-C3H7O-CO-CH2388 仲-C4H9O-COCH2389C6H5-CO-CH23902-CH3-C6H4O-CO-CH23913-CH3-C6H4O-CO-CH23924-CH3-C6H4O-CO-CH23932-Cl-C6H4O-CO-CH23943-Cl-C6H4O-CO-CH23954-Cl-C6H4-CO-CH2396C6H5-C(CH3)＝CH-CH2397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462N≡C-CH2463t-BuO-CH2-CH＝CH-CH2464(CH3)2-C＝CH-CH2-CH2-C(CH3)＝CH-CH2465(CH3)2CH-C＝CH-CH2-CH2-C(CH3)＝CH-CH2466C6H5-O-CH(CH3)-CH24674-Cl-C6H4-O-CH(CH3)
表3 化合物编号R1R2R61 HH H2 HCH3H3 Ht-C4H9H4 HCH2＝CH-CH2H5 HCH2＝C(-Cl)-CH2H6 HCH2＝C(CH3)-CH2H7 HCH3CH＝CH-CH2H8 HHC≡CCH2H9 HCH3C≡C-CH2H10H环-C6H11H11HC6H5-CH2H12H2-F-C6H4-CH2H13H3-F-C6H4-CH2H14H4-F-C6H4-CH2H15H2-Cl-C6H4-CH2H16H3-Cl-C6H4-CH2H17H4-Cl-C6H4-CH2H18H2-Br-C6H4-CH2H19H3-Br-C6H4-CH2H20H4-Br-C6H4-CH2H21H2-CH3-C6H4-CH2H22H3-CH3-C6H4-CH2H23H4-CH3-C6H4-CH2H24H2-CF3-C6H4-CH2H25H3-CF3-C6H4-CH2H26H4-CF3-C6H4-CH2H27H2-i-C3H7-C6H4-CH2H28H3-i-C3H7-C6H4-CH2H29H4-i-C3H7-C6H4-CH2H30H2-t-C4H9-C6H4-CH2H31H3-t-C4H9-C6H4-CH2H32H4-t-C4H9-C6H4-CH2H33H2-CH3O-C6H4-CH2H34H3-CH3O-C6H4-CH2H35H4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH2H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3) H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3)H57H3-CH3-C6H4-CH(CH3)H58H4-CH3-C6H4-CH(CH3)H59H2-CF3-C6H4-CH(CH3)H60H3-CF3C6H4-CH(CH3) H61H4-CF-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3)H63H3-t-C4H9-C6H4-CH(CH3)H64H4-t-C4H9-C6H4-CH(CH3)H65H2-CH3O-C6H4-CH(CH3) H66H3-CH3O-C6H4-CH(CH3) H67H4-CH3O-C6H4-CH(CH3) H68H2-氰基-C6H4-CH(CH3)H69H3-氰基-C6H4-CH(CH3)H70H4-氰基-C6H4-CH(CH3)H71H2，4-Cl2-C6H3-CH(CH3) H72H3，4-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3) H81HN≡C-CH2H82HC6H5CO-CH2H83 H 吡啶-2-基-甲基 H84 H 吡嗪-2-基-甲基 H85 H 嘧啶-2-基-甲基 H86 H 呋喃-2-基-甲基 H87 H 吡咯-2-基-甲基 H88 H N-甲基-吡咯-2-基-甲基 H89 H 噻吩-2-基-甲基 H90 H 异噁唑-5-基-甲基H91 H 噻唑-2-基-甲基 H92 H 噻唑-5-基-甲基 H93 H 噁唑-2-基-甲基 H94 H 吡唑-3-基-甲基 H95 H 苯并呋喃-2-基-甲基 H96 H 吲哚-2-基-甲基 H97 H 吲哚-3-基-甲基 H98 H 苯并噻唑-2-基-甲基 H99 H 喹啉-2-基-甲基 H100 H 4-Cl-C6H4OCH(CH3)-CH2H101 CH3H H102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3环-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128 CH33-i-C3H7-C6H4-CH2H129 CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3)H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3) H158CH34-CH3-C6H4-CH(CH3) H159CH32-CF3-C6H4-CH(CH3) H160CH33-CF3-C6H4-CH(CH3) H161CH34-CF3-C6H4-CH(CH3) H162CH32-t-C4H9-C6H4-CH(CH3) H163CH33-t-C4H9-C6H4-CH(CH3) H164CH34-t-C4H9-C6H4-CH(CH3) H165CH32-CH3O-C6H4-CH(CH3)H166CH33-CH3O-C6H4-CH(CH3)H167CH34-CH3O-C6H4-CH(CH3)H168CH32-氰基-C6H4-CH(CH3) H169CH33-氰基-C6H4-CH(CH3) H170CH34-氰基-C6H4-CH(CH3) H171CH32，4-C12-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3H176CH3CH3OOC-CH2H177 CH3C2H5OOC-CH2H178 CH3i-C3H7OOC-CH2H179 CH3t-C4H9OOC-CH2H180 CH3t-C4H9OOC-CH(CH3) H181 CH3N≡C-CH2H182 CH3C6H5CO-CH2H183 CH3吡啶-2-基-甲基 H184 CH3吡嗪-2-基-甲基 H185 CH3嘧啶-2-基-甲基 H186 CH3呋喃-2-基-甲基 H187 CH3吡咯-2-基-甲基 H188 CH3N-甲基-吡咯-2-基-甲基 H189 CH3噻吩-2-基-甲基 H190 CH3异噁唑-5-基-甲基H191 CH3噻唑-2-基-甲基 H192 CH3噻唑-5-基-甲基 H193 CH3噁唑-2-基-甲基 H194 CH3吡唑-3-基-甲基 H195 CH3苯并呋喃-2-基-甲基 H196 CH3吲哚-2-基-甲基 H197 CH3吲哚-3-基-甲基 H198 CH3苯并噻唑-2-基-甲基 H199 CH3喹啉-2-基-甲基 H200 CH34-Cl-C6H4OCH(CH3)-CH2H201 H H CH3202 H CH3CH3203 H t-C4H9CH3204 H CH2＝CH-CH2CH3205 H CH2＝C(-Cl)-CH2CH3206 H CH2＝C(CH3)-CH2CH3207 H CH3CH＝CH-CH2CH3208 H HC≡CCH2CH3209 H CH3C≡C-CH2CH3210 H 环-C6H11CH3211 H C6H5-CH2CH3212 H 2-F-C6H4-CH2CH3213 H 3-F-C6H4-CH2CH3214 H 4-F-C6H4-CH2CH3215 H 2-Cl-C6H4-CH2CH3216 H 3-Cl-C6H4-CH2CH3217 H 4-Cl-C6H4-CH2CH3218 H 2-Br-C6H4-CH2CH3219 H 3-Br-C6H4-CH2CH3220 H 4-Br-C6H4-CH2CH3221 H 2-CH3-C6H4-CH2CH3222 H 3-CH3-C6H4-CH2CH3223 H 4-CH3-C6H4-CH2CH3224H2-CF3-C6H4-CH2CH3225H3-CF3-C6H4-CH2CH3226H4-CF3-C6H4-CH2CH3227H2-i-C3H7-C6H4-CH2CH3228H3-i-C3H7-C6H4-CH2CH3229H4-i-C3H7-C6H4-CH2CH3230H2-t-C4H9-C6H4-CH2CH3231H3-t-C4H9-C6H4-CH2CH3232H4-t-C4H9-C6H4-CH2CH3233H2-CH3O-C6H4-CH2CH3234H3-CH3O-C6H4-CH2CH3235H4-CH3O-C6H4-CH2CH3236H2-氰基-C6H4-CH2CH3237H3-氰基-C6H4-CH2CH3238H4-氰基-C6H4-CH2CH3239H2-硝基-C6H4-CH2CH3240H3-硝基-C6H4-CH2CH3241H4-硝基-C6H4-CH2CH3242H2，4-Cl2-C6H3-CH2CH3243H3，4-Cl2-C6H3-CH2CH3244H3，5-Cl2-C6H3-CH2CH3245H2，6-Cl2-C6H3-CH2CH3246H2，4-(CH3)2-C6H3-CH2CH3247H2，5-(CH3)2-C6H3-CH2CH3248H3，4-(CH3)2-C6H3-CH2CH3249H3，5-(CH3)2-C6H3-CH2CH3250H1-萘基-CH2CH3251H2-萘基-CH2CH3252HC6H5-CH(CH3) CH3253H2-Cl-C6H4-CH(CH3) CH3254H3-Cl-C6H4-CH(CH3) CH3255H4-Cl-C6H4-CH(CH3) CH3256H2-CH3-C6H4-CH(CH3) CH3257H3-CH3-C6H4-CH(CH3) CH3258H4-CH3-C6H4-CH(CH3) CH3259H2-CF3-C6H4-CH(CH3) CH3260H3-CF3-C6H4-CH(CH3) CH3261H4-CF3-C6H4-CH(CH3) CH3262H2-t-C4H9-C6H4-CH(CH3) CH3263H3-t-C4H9-C6H4-CH(CH3) CH3264H4-t-C4H9-C6H4-CH(CH3) CH3265H2-CH3O-C6H4-CH(CH3) CH3266H3-CH3O-C6H4-CH(CH3) CH3267H4-CH3O-C6H4-CH(CH3) CH3268H2-氰基-C6H4-CH(CH3) CH3269H3-氰基-C6H4-CH(CH3) CH3270H4-氰基-C6H4-CH(CH3) CH3271H2，4-Cl2-C6H3-CH(CH3) CH3272H3，4-Cl2-C6H3-CH(CH3) CH3273H3，5-Cl2-C6H3-CH(CH3) CH3274H2，4-(CH3)2-C6H3-CH(CH3) CH3275H2，5-(CH3)2-C6H3-CH(CH3) CH3276HCH3OOC-CH2CH3277HC2H5OOC-CH2CH3278Hi-C3H7OOC-CH2CH3279Ht-C4H9OOC-CH2CH3280Ht-C4H9OOC-CH(CH3)CH3281HN≡C-CH2CH3282HC6H5CO-CH2CH3283H吡啶-2-基-甲基 CH3284H吡嗪-2-基-甲基 CH3285H嘧啶-2-基-甲基 CH3286H呋喃-2-基-甲基 CH3287H吡咯-2-基-甲基 CH3288HN-甲基-吡咯-2-基-甲基CH3289H噻吩-2-基-甲基 CH3290H异噁唑-5-基-甲基 CH3291H噻唑-2-基-甲基 CH3292H噻唑-5-基-甲基 CH3293H噁唑-2-基-甲基 CH3294H吡唑-3-基-甲基 CH3295H苯并呋喃-2-基-甲基 CH3296H吲哚-2-基-甲基 CH3297H吲哚-3-基-甲基 CH3298H苯并噻唑-2-基-甲基 CH3299H喹啉-2-基-甲基 CH3300H4-Cl-C6H4OCH(CH3)-CH2CH3301CH3H CH3302CH3CH3CH3303CH3t-C4H9CH3304CH3CH2＝CH-CH2CH3305CH3CH2＝C(-Cl)-CH2CH3306CH3CH2＝C(CH3)-CH2CH3307CH3CH3CH＝CH-CH2CH3308CH3HC≡CCH2CH3309CH3CH3C≡C-CH2CH3310CH3环-C6H11CH3311CH3C6H5-CH2CH3332CH32-F-C6H4-CH2CH3313CH33-F-C6H4-CH2CH3314CH34-F-C6H4-CH2CH3315CH32-Cl-C6H4-CH2CH3316CH33-Cl-C6H4-CH2CH3317CH34-Cl-C6H4-CH2CH3318CH32-Br-C6H4-CH2CH3319CH33-Br-C6H4-CH2CH3320CH34-Br-C6H4-CH2CH3321CH32-CH3-C6H4-CH2CH3322CH33-CH3-C6H4-CH2CH3323CH34-CH3-C6H4-CH2CH3324CH32-CF3-C6H4-CH2CH3325CH33-CF3-C6H4-CH2CH3326CH34-CF3-C6H4-CH2CH3327CH32-i-C3H7-C6H4-CH2CH3328CH33-i-C3H7-C6H4-CH2CH3329CH34-i-C3H7-C6H4-CH2CH3330CH32-t-C4H9-C6H4-CH2CH3331CH33-t-C4H9-C6H4-CH2CH3332CH34-t-C4H9-C6H4-CH2CH3333CH32-CH3O-C6H4-CH2CH3334CH33-CH3O-C6H4-CH2CH3335CH34-CH3O-C6H4-CH2CH3336CH32-氰基-C6H4-CH2CH3337CH33-氰基-C6H4-CH2CH3338CH34-氰基-C6H4-CH2CH3339CH32-硝基-C6H4-CH2CH3340CH33-硝基-C6H4-CH2CH3341CH34-硝基-C6H4-CH2CH3342CH32，4-Cl2-C6H3-CH2CH3343CH33，4-Cl2-C6H3-CH2CH3344CH33，5-Cl2-C6H3-CH2CH3345CH32，6-Cl2-C6H3-CH2CH3346CH32，4-(CH3)2-C6H3-CH2CH3347CH32，5-(CH3)2-C6H3-CH2CH3348CH33，4-(CH3)2-C6H3-CH2CH3349CH33，5-(CH3)2-C6H3-CH2CH3350CH31-萘基-CH2CH3351CH32-萘基-CH2CH3352CH3C6H5-CH(CH3)CH3353CH32-Cl-C6H4-CH(CH3) CH3354CH33-Cl-C6H4-CH(CH3) CH3355CH34-Cl-C6H4-CH(CH3) CH3356CH32-CH3-C6H4-CH(CH3) CH3357CH33-CH3-C6H4-CH(CH3) CH3358CH34-CH3-C6H4-CH(CH3) CH3359CH32-CF3-C6H4-CH(CH3) CH3360CH33-CF3-C6H4-CH(CH3) CH3361CH34-CF3-C6H4-CH(CH3) CH3362CH32-t-C4H9-C6H4-CH(CH3) CH3363CH33-t-C4H9-C6H4-CH(CH3) CH3364CH34-t-C4H9-C6H4-CH(CH3) CH3365CH32-CH3O-C6H4-CH(CH3) CH3366CH33-CH3O-C6H4-CH(CH3) CH3367CH34-CH3O-C6H-CH(CH3) CH3368CH32-氰基-C6H4-CH(CH3) CH3369CH33-氰基-C6H4-CH(CH3) CH3370CH34-氰基-C6H4-CH(CH3) CH3371CH32，4-Cl2-C6H3-CH(CH3) CH3372CH33，4-Cl2-C6H3-CH(CH3) CH3373CH33，5-Cl2-C6H3-CH(CH3) CH3374CH32，4-(CH3)2-C6H3-CH(CH3) CH3375CH32，5-(CH3)2-C6H3-CH(CH3CH3376CH3CH3OOC-CH2CH3377CH3C2H5OOC-CH2CH3378CH3i-C3H7OOC-CH2CH3379CH3t-C4H9OOC-CH2CH3380CH3t-C4H9OOC-CH(CH3)CH3381CH3N≡C-CH2CH3382CH3C6H5CO-CH2CH3383CH3吡啶-2-基-甲基 CH3384CH3吡嗪-2-基-甲基 CH3385CH3嘧啶-2-基-甲基 CH3386CH3呋喃-2-基-甲基 CH3387CH3吡咯-2-基-甲基 CH3388CH3N-甲基-吡咯-2-基-甲基CH3389CH3噻吩-2-基-甲基 CH3390CH3异噁唑-5-基-甲基 CH3391CH3噻唑-2-基-甲基 CH3392CH3噻唑-5-基-甲基 CH3393CH3噁唑-2-基-甲基 CH3394CH3吡唑-3-基-甲基 CH3395CH3苯并呋喃-2-基-甲基 CH3396CH3吲哚-2-基-甲基 CH3397CH3吲哚-3-基-甲基 CH3398CH3苯并噻唑-2-基-甲基 CH3399CH3喹啉-2-基-甲基 CH3400CH34-Cl-C6H4OCH(CH3)-CH2CH3
表4 化合物编号R1R2R41 HH H2 HCH3H3 Ht-C4H9H4 HCH2＝CH-CH2H5 HCH2＝C(-Cl)-CH2H6 HCH2＝C(CH3)-CH2H7 HCH3CH＝CH-CH2H8 HHC≡CCH2H9 HCH3C≡C-CH2H10H环-C6H11H11HC6H5-CH2H12H2-F-C6H4-CH2H13H3-F-C6H4-CH2H14H4-F-C6H4-CH2H15H2-Cl-C6H4-CH2H16H3-Cl-C6H4-CH2H17H4-Cl-C6H4-CH2H18H2-Br-C6H4-CH2H19H3-Br-C6H4-CH2H20H4-Br-C6H4-CH2H21H2-CH3-C6H4-CH2H22H3-CH3-C6H4-CH2H23H4-CH3-C6H4-CH2H24H2-CF3-C6H4-CH2H25H3-CF3-C6H4-CH2H26H4-CF3-C6H4-CH2H27H2-i-C3H7-C6H4-CH2H28H3-i-C3H7-C6H4-CH2H29H4-i-C3H7-C6H4-CH2H30H2-t-C4H9-C6H4-CH2H31H3-t-C4H9-C6H4-CH2H32H4-t-C4H9-C6H4-CH2H33H2-CH3O-C6H4-CH2H34H3-CH3O-C6H4-CH2H35H4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH3H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3)H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3) H57H3-CH3-C6H4-CH(CH3) H58H4-CH3-C6H4-CH(CH3) H59H2-CF3-C6H4-CH(CH3) H60H3-CF3-C6H4-CH(CH3) H61H4-CF3-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3) H63H3-t-C4H9-C6H4-CH(CH3) H64H4-t-C4H9-C6H4-CH(CH3) H65H2-CH3O-C6H4-CH(CH3)H66H3-CH3O-C6H4-CH(CH3)H67H4-CH3O-C6H4-CH(CH3)H68H2-氰基-C6H4-CH(CH3) H69H3-氰基-C6H4-CH(CH3) H70H4-氰基-C6H4-CH(CH3) H71H2，4-Cl2-C6H3-CH(CH3) H72H3，4-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3)H81 HN≡C-CH2H82 HC6H5CO-CH2H83 H吡啶-2-基-甲基H84 H吡嗪-2-基-甲基H85 H嘧啶-2-基-甲基H86 H呋喃-2-基-甲基H87 H吡咯-2-基-甲基H88 HN-甲基-吡咯-2-基-甲基 H89 H噻吩-2-基-甲基H90 H异噁唑-5-基-甲基 H91 H噻唑-2-基-甲基H92 H噻唑-5-基-甲基H93 H噁唑-2-基-甲基H94 H吡唑-3-基-甲基H95 H苯并呋喃-2-基-甲基H96 H吲哚-2-基-甲基H97 H吲哚-3-基-甲基H98 H苯并噻唑-2-基-甲基H99 H喹啉-2-基-甲基H100 H4-Cl-C6H4OCH(CH3)-CH2H101 CH3H H102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3环-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128CH33-i-C3H7-C6H4-CH2H129CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3) H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3)H158CH34-CH3-C6H4-CH(CH3)H159CH32-CF3-C6H4-CH(CH3)H160CH33-CF3-C6H4-CH(CH3)H161CH34-CF3-C6H4-CH(CH3)H162CH32-t-C4H9-C6H4-CH(CH3)H163CH33-t-C4H9-C6H4-CH(CH3)H164CH34-t-C4H9-C6H4-CH(CH3)H165CH32-CH3O-C6H4-CH(CH3) H166CH33-CH3O-C6H4-CH(CH3) H167CH34-CH3O-C6H4-CH(CH3) H168CH32-氰基-C6H4-CH(CH3)H169CH33-氰基-C6H4-CH(CH3)H170CH34-氰基-C6H4-CH(CH3)H171CH32，4-Cl2-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3) H176CH3CH3OOC-CH2H177CH3C2H5OOC-CH2H178CH3i-C3H7OOC-CH2H179CH3t-C4H9OOC-CH2H180CH3t-C4H9OOC-CH(CH3) H181CH3N≡C-CH2H182CH3C6H5CO-CH2H183CH3吡啶-2-基-甲基 H184CH3吡嗪-2-基-甲基 H185CH3嘧啶-2-基-甲基 H186CH3呋喃-2-基-甲基 H187CH3吡咯-2-基-甲基 H188CH3N-甲基-吡咯-2-基-甲基 H189CH3噻吩-2-基-甲基 H190CH3异噁唑-5-基-甲基H191CH3噻唑-2-基-甲基 H192CH3噻唑-5-基-甲基 H193CH3噁唑-2-基-甲基 H194CH3吡唑-3-基-甲基 H195CH3苯并呋喃-2-基-甲基 H196CH3吲哚-2-基-甲基 H197CH3吲哚-3-基-甲基 H198CH3苯并噻唑-2-基-甲基 H199CH3喹啉-2-基-甲基 H200CH34-Cl-C6H4OCH(CH3)-CH2H201H HC2H5202H CH3C2H5203H t-C4H9C2H5204H CH2＝CH-CH2C2H5205H CH2＝C(-Cl)-CH2C2H5206H CH2＝C(CH3)-CH2C2H5207H CH3CH＝CH-CH2C2H5208H HC≡CCH2C2H5209H CH3C≡C-CH2C2H5210H 环-C6H11C2H5211H C6H5-CH2C2H5212H 2-F-C6H4-CH2C2H5213H 3-F-C6H4-CH2C2H5214H 4-F-C6H4-CH2C2H5215H 2-Cl-C6H4-CH2C2H5216H 3-Cl-C6H4-CH2C2H5217H 4-Cl-C6H4-CH2C2H5218H 2-Br-C6H4-CH2C2H5219H 3-Br-C6H4-CH2C2H5220H 4-Br-C6H4-CH2C2H5221H 2-CH3-C6H4-CH2C2H5222H3-CH3-C6H4-CH2C2H5223H4-CH3-C6H4-CH2C2H5224H2-CF3-C6H4-CH2C2H5225H3-CF3-C6H4-CH2C2H5226H4-CF3-C6H4-CH2C2H5227H2-i-C3H7-C6H4-CH2C2H5228H3-i-C3H7-C6H4-CH2C2H5229H4-i-C3H7-C6H4-CH2C2H5230H2-t-C4H9-C6H4-CH2C2H5231H3-t-C4H9-C6H4-CH2C2H5232H4-t-C4H9-C6H4-CH2C2H5233H2-CH3O-C6H4-CH2C2H5234H3-CH3O-C6H4-CH2C2H5235H4-CH3O-C6H4-CH2C2H5236H2-氰基-C6H4-CH2C2H5237H3-氰基-C6H4-CH2C2H5238H4-氰基-C6H4-CH2C2H5239H2-硝基-C6H4-CH2C2H5240H3-硝基-C6H4-CH2C2H5241H4-硝基-C6H4-CH2C2H5242H2，4-Cl2-C6H3-CH2C2H5243H3，4-Cl2-C6H3-CH2C2H5244H3，5-Cl2-C6H3-CH2C2H5245H2，6-Cl2-C6H3-CH2C2H5246H2，4-(CH3)2-C6H3-CH2C2H5247H2，5-(CH3)2-C6H3-CH2C2H5248H3，4-(CH3)2-C6H3-CH2C2H5249H3，5-(CH3)2-C6H3-CH2C2H5250H1-萘基-CH2C2H5251H2-萘基-CH2C2H5252HC6H5-CH(CH3)C2H5253H2-Cl-C6H4-CH(CH3) C2H5254H3-Cl-C6H4-CH(CH3) C2H5255H4-Cl-C6H4-CH(CH3) C2H5256H2-CH3-C6H4-CH(CH3) C2H5257H3-CH3-C6H4-CH(CH3) C2H5258H4-CH3-C6H4-CH(CH3) C2H5259H2-CF3-C6H4-CH(CH3) C2H5260H3-CF3-C6H4-CH(CH3) C2H5261H4-CF3-C6H4-CH(CH3) C2H5262H2-t-C4H9-C6H4-CH(CH3) C2H5263H3-t-C4H9-C6H4-CH(CH3) C2H5264H4-t-C4H9-C6H4-CH(CH3) C2H5265H2-CH3O-C6H4-CH(CH3)C2H5266H3-CH3O-C6H4-CH(CH3)C2H5267H4-CH3O-C6H4-CH(CH3)C2H5268H2-氰基-C6H4-CH(CH3) C2H5269 H3-氰基-C6H4-CH(CH3)C2H5270 H4-氰基-C6H4-CH(CH3)C2H5271 H2，4-Cl2-C6H3-CH(CH3) C2H5272 H3，4-Cl2-C6H3-CH(CH3) C2H5273 H3，5-Cl2-C6H3-CH(CH3) C2H5274 H2，4-(CH3)2-C6H3-CH(CH3) C2H5275 H2，5-(CH3)2-C6H3-CH(CH3) C2H5276 HCH3OOC-CH2C2H5277 HC2H5OOC-CH2C2H5278 Hi-C3H7OOC-CH2C2H5279 Ht-C4H9OOC-CH2C2H5280 Ht-C4H9OOC-CH(CH3) C2H5281 HN≡C-CH2C2H5282 HC6H5CO-CH2C2H5283 H吡啶-2-基-甲基 C2H5284 H吡嗪-2-基-甲基 C2H5285 H嘧啶-2-基-甲基 C2H5286 H呋喃-2-基-甲基 C2H5287 H吡咯-2-基-甲基 C2H5288 HN-甲基-吡咯-2-基-甲基 C2H5289 H噻吩-2-基-甲基 C2H5290 H异噁唑-5-基-甲基C2H5291 H噻唑-2-基-甲基 C2H5292 H噻唑-5-基-甲基 C2H5293 H噁唑-2-基-甲基 C2H5294 H吡唑-3-基-甲基 C2H5295 H苯并呋喃-2-基-甲基 C2H5296 H吲哚-2-基-甲基 C2H5297 H吲哚-3-基-甲基 C2H5298 H苯并噻唑-2-基-甲基 C2H5299 H喹啉-2-基-甲基 C2H5300 H4-Cl-C6H4OCH(CH3)-CH2C2H5301 CH3H C2H5302 CH3CH3C2H5303 CH3t-C4H9C2H5304 CH3CH2＝CH-CH2C2H5305 CH3CH2＝C(-Cl)-CH2C2H5306 CH3CH2＝C(CH3)-CH2C2H5307 CH3CH3CH＝CH-CH2C2H5308 CH3HC≡CCH2C2H5309 CH3CH3C≡C-CH2C2H5310 CH3环-C6H11C2H5311 CH3C6H5-CH2C2H5332 CH32-F-C6H4-CH2C2H5313 CH33-F-C6H4-CH2C2H5314 CH34-F-C6H4-CH2C2H5315 CH32-Cl-C6H4-CH2C2H5316CH33-Cl-C6H4-CH2C2H5317CH34-Cl-C6H4-CH2C2H5318CH32-Br-C6H4-CH2C2H5319CH33-Br-C6H4-CH2C2H5320CH34-Br-C6H4-CH2C2H5321CH32-CH3-C6H4-CH2C2H5322CH33-CH3-C5H4-CH2C2H5323CH34-CH3-C6H4-CH2C2H5324CH32-CF3-C6H4-CH2C2H5325CH33-CF3-C6H4-CH2C2H5326CH34-CF3-C6H4-CH2C2H5327CH32-i-C3H7-C6H4-CH2C2H5328CH33-i-C3H7-C6H4-CH2C2H5329CH34-i-C3H7-C6H4-CH2C2H5330CH32-t-C4H9-C6H4-CH2C2H5331CH33-t-C4H9-C6H4-CH2C2H5332CH34-t-C4H9-C6H4-CH2C2H5333CH32-CH3O-C6H4-CH2C2H5334CH33-CH3O-C6H4-CH2C2H5335CH34-CH3O-C6H4-CH2C2H5336CH32-氰基-C6H4-CH2C2H5337CH33-氰基-C6H4-CH2C2H5338CH34-氰基-C6H4-CH2C2H5339CH32-硝基-C6H4-CH2C2H5340CH33-硝基-C6H4-CH2C2H5341CH34-硝基-C6H4-CH2C2H5342CH32，4-Cl2-C6H3-CH2C2H5343CH33，4-Cl2-C6H3-CH2C2H5344CH33，5-Cl2-C6H3-CH2C2H5345CH32，6-Cl2-C6H3-CH2C2H5346CH32，4-(CH3)2-C6H3-CH2C2H5347CH32，5-(CH3)2-C6H3-CH2C2H5348CH33，4-(CH3)2-C6H3-CH2C2H5349CH33，5-(CH3)2-C6H3-CH2C2H5350CH31-萘基-CH2C2H5351CH32-萘基-CH2C2H5352CH3C6H5-CH(CH3)C2H5353CH32-Cl-C6H4-CH(CH3) C2H5354CH33-Cl-C6H4-CH(CH3) C2H5355CH34-Cl-C6H4-CH(CH3) C2H5356CH32-CH3-C6H4-CH(CH3) C2H5357CH33-CH3-C6H4-CH(CH3) C2H5358CH34-CH3-C6H4-CH(CH3) C2H5359CH32-CF3-C6H4-CH(CH3) C2H5360CH33-CF3-C6H4-CH(CH3) C2H5361CH34-CF3-C6H4-CH(CH3) C2H5362CH32-t-C4H9-C6H4-CH(CH3) C2H5363CH33-t-C4H9-C6H4-CH(CH3)C2H5364CH34-t-C4H9-C6H4-CH(CH3)C2H5365CH32-CH3O-C6H4-CH(CH3) C2H5366CH33-CH3O-C6H4-CH(CH3) C2H5367CH34-CH3O-C6H4-CH(CH3) C2H5368CH32-氰基-C6H4-CH(CH3)C2H5369CH33-氰基-C6H4-CH(CH3)C2H5370CH34-氰基-C6H4-CH(CH3)C2H5371CH32，4-Cl2-C6H3-CH(CH3) C2H5372CH33，4-Cl2-C6H3-CH(CH3) C2H5373CH33，5-Cl2-C6H3-CH(CH3) C2H5374CH32，4-(CH3)2-C6H3-CH(CH3) C2H5375CH32，5-(CH3)2-C6H3-CH(CH3) C2H5376CH3CH3OOC-CH2C2H5377CH3C2H5OOC-CH2C2H5378CH3i-C3H7OOC-CH2C2H5379CH3t-C4H9OOC-CH2C2H5380CH3t-C4H9OOC-CH(CH3) C2H5381CH3N≡C-CH2C2H5382CH3C6H5CO-CH2C2H5383CH3吡啶-2-基-甲基 C2H5384CH3吡嗪-2-基-甲基 C2H5385CH3嘧啶-2-基-甲基 C2H5386CH3呋喃-2-基-甲基 C2H5387CH3吡咯-2-基-甲基 C2H5388CH3N-甲基-吡咯-2-基-甲基 C2H5389CH3噻吩-2-基-甲基 C2H5390CH3异噁唑-5-基-甲基 C2H5391CH3噻唑-2-基-甲基 C2H5392CH3噻唑-5-基-甲基 C2H5393CH3噁唑-2-基-甲基 C2H5394CH3吡唑-3-基-甲基 C2H5395CH3苯并呋喃-2-基-甲基 C2H5396CH3吲哚-2-基-甲基 C2H5397CH3吲哚-3-基-甲基 C2H5398CH3苯并噻唑-2-基-甲基 C2H5399CH3喹啉-2-基-甲基 C2H5400CH34-Cl-C6H4OCH(CH3)-CH2C2H5
表5 化合物编号R1R21 HH2 HCH33 Ht-C4H94 HCH2＝CH-CH25 HCH2＝C(-Cl)-CH26 HCH2＝C(CH3)-CH27 HCH3CH＝CH-CH28 HHC≡CCH29 HCH3C≡C-CH210H环-C6H1111HC6H5-CH212H2-F-C6H4-CH213H3-F-C6H4-CH214H4-F-C6H4-CH215H2-Cl-C6H4-CH216H3-Cl-C6H4-CH217H4-Cl-C6H4-CH218H2-Br-C6H4-CH219H3-Br-C6H4-CH220H4-Br-C6H4-CH221H2-CH3-C6H4-CH222H3-CH3-C6H4-CH223H4-CH3-C6H4-CH224H2-CF3-C6H4-CH225H3-CF3-C6H4-CH226H4-CF3-C6H4-CH227H2-i-C3H7-C6H4-CH228H3-i-C3H7-C6H4-CH229H4-i-C3H7-C6H4-CH230H2-t-C4H9-C6H4-CH231H3-t-C4H9-C6H4-CH232H4-t-C4H9-C6H4-CH233H2-CH3O-C6H4-CH234H3-CH3O-C6H4-CH235H4-CH3O-C6H4-CH236H2-氰基-C6H4-CH237H3-氰基-C6H4-CH238H4-氰基-C6H4-CH239H2-硝基-C6H4-CH240H3-硝基-C6H4-CH241H4-硝基-C6H4-CH242H2，4-Cl2-C6H3-CH243H3，4-Cl2-C6H3-CH244H3，5-Cl2-C6H3-CH245H2，6-Cl2-C6H3-CH246H2，4-(CH3)2-C6H3-CH247H2，5-(CH3)2-C6H3-CH248H3，4-(CH3)2-C6H3-CH249H3，5-(CH3)2-C6H3-CH250H1-萘基-CH251H2-萘基-CH252HC6H5-CH(CH3)53H2-Cl-C6H4-CH(CH3)54H3-Cl-C6H4-CH(CH3)55H4-Cl-C6H4-CH(CH3)56H2-CH3-C6H4-CH(CH3)57H3-CH3-C6H4-CH(CH3)58H4-CH3-C6H4-CH(CH3)59H2-CF3-C6H4-CH(CH3)60H3-CF3-C6H4-CH(CH3)61H4-CF3-C6H4-CH(CH3)62H2-t-C4H9-C6H4-CH(CH3)63H3-t-C4H9-C6H4-CH(CH3)64H4-t-C4H9-C6H4-CH(CH3)65H2-CH3O-C6H4-CH(CH3)66H3-CH3O-C6H4-CH(CH3)67H4-CH3O-C6H4-CH(CH3)68H2-氰基-C6H4-CH(CH3)69H3-氰基-C6H4-CH(CH3)70H4-氰基-C6H4-CH(CH3)71H2，4-Cl2-C6H3-CH(CH3)72H3，4-Cl2-C6H3-CH(CH3)73H3，5-Cl2-C6H3-CH(CH3)74H2，4-(CH3)2-C6H3-CH(CH3)75H2，5-(CH3)2-C6H3-CH(CH3)76HCH3OOC-CH277HC2H5OOC-CH278Hi-C3H7OOC-CH279Ht-C4H9OOC-CH280Ht-C4H9OOC-CH(CH3)81HN≡C-CH282 H C6H5CO-CH283 H 吡啶-2-基-甲基84 H 吡嗪-2-基-甲基85 H 嘧啶-2-基-甲基86 H 呋喃-2-基-甲基87 H 吡咯-2-基-甲基88 H N-甲基-吡咯-2-基-甲基89 H 噻吩-2-基-甲基90 H 异噁唑-5-基-甲基91 H 噻唑-2-基-甲基92 H 噻唑-5-基-甲基93 H 噁唑-2-基-甲基94 H 吡唑-3-基-甲基95 H 苯并呋喃-2-基-甲基96 H 吲哚-2-基-甲基97 H 吲哚-3-基-甲基98 H 苯并噻唑-2-基-甲基99 H 喹啉-2-基-甲基100 H 4-Cl-C6H4OCH(CH3)-CH2101 CH3H102 CH3CH3103 CH3t-C4H9104 CH3CH2＝CH-CH2105 CH3CH2＝C(-Cl)-CH2106 CH3C(CH3)-CH2107 CH3CH3CH＝CH-CH2108 CH3HC≡CCH2109 CH3CH3C≡C-CH2110 CH3环o-C6H11111 CH3C6H5-CH2112 CH32-F-C6H4-CH2113 CH33-F-C6H4-CH2114 CH34-F-C6H4-CH2115 CH32-Cl-C6H4-CH2116 CH33-Cl-C6H4-CH2117 CH34-Cl-C6H4-CH2118 CH32-Br-C6H4-CH2119 CH33-Br-C6H4-CH2120 CH34-Br-C6H4-CH2121 CH32-CH3-C6H4-CH2122 CH33-CH3-C6H4-CH2123 CH34-CH3-C6H4-CH2124 CH32-CF3-C6H4-CH2125 CH33-CF3-C6H4-CH2126 CH34-CF3-C6H4-CH2127 CH32-i-C3H7-C6H4-CH2128 CH33-i-C3H7-C6H4-CH2129CH34-i-C3H7-C6H4-CH2130CH32-t-C4H9-C6H4-CH2131CH33-t-C4H9-C6H4-CH2132CH34-t-C4H9-C6H4-CH2133CH32-CH3O-C6H4-CH2134CH33-CH3O-C6H4-CH2135CH34-CH3O-C6H4-CH2136CH32-氰基-C6H4-CH2137CH33-氰基-C6H4-CH2138CH34-氰基-C6H4-CH2139CH32-硝基-C6H4-CH2140CH33-硝基-C6H4-CH2141CH34-硝基-C6H4-CH2142CH32，4-Cl2-C6H3-CH2143CH33，4-Cl2-C6H3-CH2144CH33，5-Cl2-C6H3-CH2145CH32，6-Cl2-C6H3-CH2146CH32，4-(CH3)2-C6H3-CH2147CH32，5-(CH3)2-C6H3-CH2148CH33，4-(CH3)2-C6H3-CH2149CH33，5-(CH3)2-C6H3-CH2150CH31-萘基-CH2151CH32-萘基-CH2152CH3C6H5-CH(CH3)153CH32-Cl-C6H4-CH(CH3)154CH33-Cl-C6H4-CH(CH3)155CH34-Cl-C6H4-CH(CH3)156CH3CH3-C6H4-CH(CH3)157CH33-CH3-C6H4-CH(CH3)158CH34-CH3-C6H4-CH(CH3)159CH32-CF3-C6H4-CH(CH3)160CH33-CF3-C6H4-CH(CH3)161CH34-CF3-C6H4-CH(CH3)162CH32-t-C4H9-C6H4-CH(CH3)163CH33-t-C4H9-C6H4-CH(CH3)164CH34-t-C4H9-C6H4-CH(CH3)165CH32-CH3O-C6H4-CH(CH3)166CH33-CH3O-C6H4-CH(CH3)167CH34-CH3O-C6H4-CH(CH3)168CH32-氰基-C6H4-CH(CH3)169CH33-氰基-C6H4-CH(CH3)170CH34-氰基-C6H4-CH(CH3)171CH32，4-Cl2-C6H3-CH(CH3)172CH33，4-Cl2-C6H3-CH(CH3)173CH33，5-Cl2-C6H3-CH(CH3)174CH32，4-(CH3)2-C6H3-CH(CH3)175CH32，5-(CH3)2-C6H3-C(CH3)2176CH3CH3OOC-CH2177CH3C2H5OOC-CH2178CH3i-C3H7OOC-CH2179CH3t-C4H9OOC-CH2180CH3t-C4H9OOC-CH(CH3)181CH3N≡C-CH2182CH3C6H5CO-CH2183CH3吡啶-2-基-甲基184CH3吡嗪-2-基-甲基185CH3嘧啶-2-基-甲基186CH3呋喃-2-基-甲基187CH3吡咯-2-基-甲基188CH3N-甲基-吡咯-2-基-甲基189CH3噻吩-2-基-甲基190CH3异噁唑-5-基-甲基191CH3噻唑-2-基-甲基192CH3噻唑-5-基-甲基193CH3噁唑-2-基-甲基194CH3吡唑-3-基-甲基195CH3苯并呋喃-2-基-甲基196CH3吲哚-2-基-甲基197CH3吲哚-3-基-甲基198CH3苯并噻唑-2-基-甲基199CH3喹啉-2-基-甲基200CH34-Cl-C6H4OCH(CH3)-CH2
表6 化合物编号R1R2R4R61 H H HH2 H CH3HH3 H t-C4H9HH4 H CH2＝CH-CH2HH5 H CH2＝C(-Cl)-CH2HH6 H CH2＝C(CH3)-CH2HH7 H CH3CH＝CH-CH2HH8 H HC≡CCH2HH9 H CH3C≡C-CH2HH10H 环-C6H11HH11H C6H5-CH2HH12H 2-F-C6H4-CH2HH13H 3-F-C6H4-CH2HH14H 4-F-C6H4-CH2HH15H 2-Cl-C6H4-CH2HH16H 3-Cl-C6H4-CH2HH17H 4-Cl-C6H4-CH2HH18H 2-Br-C6H4-CH2HH19H 3-Br-C6H4-CH2HH20H 4-Br-C6H4-CH2HH21H 2-CH3-C6H4-CH2HH22H 3-CH3-C6H4-CH2HH23H 4-CH3-C6H4-CH2HH24H 2-CF3-C6H4-CH2HH25H 3-CF3-C6H4-CH2HH26H 4-CF3-C6H4-CH2HH27H 2-i-C3H7-C6H4-CH2HH28H 3-i-C3H7-C6H4-CH2HH29H 4-i-C3H7-C6H4-CH2HH30H 2-t-C4H9-C6H4-CH2HH31H 3-t-C4H9-C6H4-CH2HH32H 4-t-C4H9-C6H4-CH2HH33H 2-CH3O-C6H4-CH2HH34H 3-CH3O-C6H4-CH2HH35H 4-CH3O-C6H4-CH2HH36H2-氰基-C6H4-CH2HH37H3-氰基-C6H4-CH2HH38H4-氰基-C6H4-CH2HH39H2-硝基-C6H4-CH2HH40H3-硝基-C6H4-CH2HH41H4-硝基-C6H4-CH2HH42H2，4-Cl2-C6H3-CH2HH43H3，4-Cl2-C6H3-CH2HH44H3，5-Cl2-C6H3-CH2HH45H2，6-Cl2-C6H3-CH2HH46H2，4-(CH3)2-C6H3-CH2HH47H2，5-(CH3)2-C6H3-CH2HH48H3，4-(CH3)2-C6H3-CH2HH49H3，5-(CH3)2-C6H3-CH2HH50H1-萘基-CH2HH51H2-萘基-CH2HH52HC6H5-CH(CH3) HH53H2-Cl-C6H4-CH(CH3) HH54H3-Cl-C6H4-CH(CH3) HH55H4-Cl-C6H4-CH(CH3) HH56H2-CH3-C6H4-CH(CH3) HH57H3-CH3-C6H4-CH(CH3) HH58H4-CH3-C6H4-CH(CH3) HH59H2-CF3-C6H4-CH(CH3) HH60H3-CF3-C6H4-CH(CH3) HH61H4-CF3-C6H4-CH(CH3) HH62H2-t-C4H9-C6H4-CH(CH3) HH63H3-t-C4H9-C6H4-CH(CH3) HH64H4-t-C4H9-C6H4-CH(CH3) HH65H2-CH3O-C6H4-CH(CH3) HH66H3-CH3O-C6H4-CH(CH3) HH67H4-CH3O-C6H4-CH(CH3) HH68H2-氰基-C6H4-CH(CH3) HH69H3-氰基-C6H4-CH(CH3) HH70H4-氰基-C6H4-CH(CH3) HH71H2，4-Cl2-C6H3-CH(CH3)HH72H3，4-Cl2-C6H3-CH(CH3)HH73H3，5-Cl2-C6H3-CH(CH3)HH74H2，4-(CH3)2-C6H3-CH(CH3)HH75H2，5-(CH3)2-C6H3-CH(CH3)HH76HCH3OOC-CH2HH77HC2H5OOC-CH2HH78Hi-C3H7OOC-CH2HH79Ht-C4H9OOC-CH2HH80Ht-C4H9OOC-CH(CH3) HH81HN≡C-CH2HH82HC6H5CO-CH2HH83 H 吡啶-2-基-甲基HH84 H 吡嗪-2-基-甲基HH85 H 嘧啶-2-基-甲基HH86 H 呋喃-2-基-甲基HH87 H 吡咯-2-基-甲基HH88 H N-甲基-吡咯-2-基-甲基 HH89 H 噻吩-2-基-甲基HH90 H 异噁唑-5-基-甲基 HH91 H 噻唑-2-基-甲基HH92 H 噻唑-5-基-甲基HH93 H 噁唑-2-基-甲基HH94 H 吡唑-3-基-甲基HH95 H 苯并呋喃-2-基-甲基HH96 H 吲哚-2-基-甲基HH97 H 吲哚-3-基-甲基HH98 H 苯并噻唑-2-基-甲基HH99 H 喹啉-2-基-甲基HH100H 4-Cl-C6H4OCH(CH3)-CH2HH101CH3H HH102CH3CH3HH103CH3t-C4H9HH104CH3CH2＝CH-CH2HH105CH3CH2＝C(-Cl)-CH2HH106CH3C(CH3)-CH2HH107CH3CH3CH＝CH-CH2HH108CH3HC≡CCH2HH109CH3CH3C≡C-CH2HH110CH3环C-C6H11HH111CH3C6H5-CH2HH112CH32-F-C6H4-CH2HH113CH33-F-C6H4-CH2HH114CH34-F-C6H4-CH2HH115CH32-Cl-C6H4-CH2HH116CH33-Cl-C6H4-CH2HH117CH34-Cl-C6H4-CH2HH118CH32-Br-C6H4-CH2HH119CH33-Br-C6H4-CH2HH120CH34-Br-C6H4-CH2HH121CH32-CH3-C6H4-CH2HH122CH33-CH3-C6H4-CH2HH123CH34-CH3-C6H4-CH2HH124CH32-CF3-C6H4-CH2HH125CH33-CF3-C6H4-CH2HH126CH34-CF3-C6H4-CH2HH127CH32-i-C3H7-C6H4-CH2HH128CH33-i-C3H7-C6H4-CH2HH129CH34-i-C3H7-C6H4-CH2HH130CH32-t-C4H9-C6H4-CH2H H131CH33-t-C4H9-C6H4-CH2H H132CH34-t-C4H9-C6H4-CH2H H133CH32-CH3O-C6H4-CH2H H134CH33-CH3O-C6H4-CH2H H135CH34-CH3O-C6H4-CH2H H136CH32-氰基-C6H4-CH2H H137CH33-氰基-C6H4-CH2H H138CH34-氰基-C6H4-CH2H H139CH32-硝基-C6H4-CH2H H140CH33-硝基-C6H4-CH2H H141CH34-硝基-C6H4-CH2H H142CH32，4-Cl2-C6H3-CH2H H143CH33，4-Cl2-C6H3-CH2H H144CH33，5-Cl2-C6H3-CH2H H145CH32，6-Cl2-C6H3-CH2H H146CH32，4-(CH3)2-C6H3-CH2H H147CH32，5-(CH3)2-C6H3-CH2H H148CH33，4-(CH3)2-C6H3-CH2H H149CH33，5-(CH3)2-C6H3-CH2H H150CH31-萘基氰-CH2H H151CH32-萘基1-CH2H H152CH3C6H5-CH(CH3) H H153CH32-Cl-C6H4-CH(CH3)H H154CH33-Cl-C6H4-CH(CH3)H H155CH34-Cl-C6H4-CH(CH3)H H156CH3CH3-C6H4-CH(CH3)H H157CH33-CH3-C6H4-CH(CH3) H H158CH34-CH3-C6H4-CH(CH3) H H159CH32-CF3-C6H4-CH(CH3) H H160CH33-CF3-C6H4-CH(CH3) H H161CH34-CF3-C6H4-CH(CH3) H H162CH32-t-C4H9-C6H4-CH(CH3) H H163CH33-t-C4H9-C6H4-CH(CH3) H H164CH34-t-C4H9-C6H4-CH(CH3) H H165CH32-CH3O-C6H4-CH(CH3) H H166CH33-CH3O-C6H4-CH(CH3) H H167CH34-CH3O-C6H4-CH(CH3) H H168CH32-氰基-C6H4-CH(CH3) H H169CH33-氰基-C6H4-CH(CH3) H H170CH34-氰基-C6H4-CH(CH3) H H171CH32，4-Cl2-C6H3-CH(CH3) H H172CH33，4-Cl2-C6H3-CH(CH3) H H173CH33，5-Cl2-C6H3-CH(CH3) H H174CH32，4-(CH3)2-C6H3-CH(CH3) H H175CH32，5-(CH3)2-C6H3-CH(CH3) H H176CH3CH3OOC-CH2H H177 CH3C2H5OOC-CH2HH178 CH3i-C3H7OOC-CH2HH179 CH3t-C4H9OOC-CH2HH180 CH3t-C4H9OOC-CH(CH3) HH181 CH3N≡C-CH2HH182 CH3C6H5CO-CH2HH183 CH3吡啶-2-基-甲基 HH184 CH3吡嗪-2-基-甲基 HH185 CH3嘧啶-2-基-甲基 HH186 CH3呋喃-2-基-甲基 HH187 CH3吡咯-2-基-甲基 HH188 CH3N-甲基-吡咯-2-基-甲基 HH189 CH3噻吩-2-基-甲基 HH190 CH3异噁唑-5-基-甲基 HH191 CH3噻唑-2-基-甲基 HH192 CH3噻唑-5-基-甲基 HH193 CH3噁唑-2-基-甲基 HH194 CH3吡唑-3-基-甲基 HH195 CH3苯并呋喃-2-基-甲基 HH196 CH3引哚-2-基-甲基 HH197 CH3吲哚-3-基-甲基 HH198 CH3苯并噻唑-2-基-甲基 HH199 CH3喹啉-2-基-甲基 HH200 CH34-Cl-C6H4OCH(CH3)-CH2HH201 H H C2H5H202 H CH3C2H5H203 H t-C4H9C2H5H204 H CH2＝CH-CH2C2H5H205 H CH2＝C(-Cl)-CH2C2H5H206 H CH2＝C(CH3)-CH2C2H5H207 H CH3CH＝CH-CH2C2H5H208 H HC≡CCH2C2H5H209 H CH3C≡C-CH2C2H5H210 H 环-C6H11C2H5H211 H C6H5-CH2C2H5H212 H 2-F-C6H4-CH2C2H5H213 H 3-F-C6H4-CH2C2H5H214 H 4-F-C6H4-CH2C2H5H215 H 2-Cl-C6H4-CH2C2H5H216 H 3-Cl-C6H4-CH2C2H5H217 H 4-Cl-C6H4-CH2C2H5H218 H 2-Br-C6H4-CH2C2H5H219 H 3-Br-C6H4-CH2C2H5H220 H 4-Br-C6H4-CH2C2H5H221 H 2-CH3-C6H4-CH2C2H5H222 H 3-CH3-C6H4-CH2C2H5H223 H 4-CH3-C6H4-CH2C2H5H224 H2-CF3-C6H4-CH2C2H5H225 H3-CF3-C6H4-CH2C2H5H226 H4-CF3-C6H4-CH2C2H5H227 H2-i-C3H7-C6H4-CH2C2H5H228 H3-i-C3H7-C6H4-CH2C2H5H229 H4-i-C3H7-C6H4-CH2C2H5H230 H2-t-C4H9-C6H4-CH2C2H5H231 H3-t-C4H9-C6H4-CH2C2H5H232 H4-t-C4H9-C6H4-CH2C2H5H233 H2-CH3O-C6H4-CH2C2H5H234 H3-CH3O-C6H4-CH2C2H5H235 H4-CH3O-C6H4-CH2C2H5H236 H2-氰基-C6H4-CH2C2H5H237 H3-氰基-C6H4-CH2C2H5H238 H4-氰基-C6H4-CH2C2H5H239 H2-硝基-C6H4-CH2C2H5H240 H3-硝基-C6H4-CH2C2H5H241 H4-硝基-C6H4-CH2C2H5H242 H2，4-Cl2-C6H3-CH2C2H5H243 H3，4-Cl2-C6H3-CH2C2H5H244 H3，5-Cl2-C6H3-CH2C2H5H245 H2，6-Cl2-C6H3-CH2C2H5H246 H2，4-(CH3)2-C6H3-CH2C2H5H247 H2，5-(CH3)2-C6H3-CH2C2H5H248 H3，4-(CH3)2-C6H3-CH2C2H5H249 H3，5-(CH3)2-C6H3-CH2C2H5H250 H1-萘基-CH2C2H5H251 H2-萘基-CH2C2H5H252 HC6H5-CH(CH3)C2H5H253 H2-Cl-C6H4-CH(CH3) C2H5H254 H3-Cl-C6H4-CH(CH3) C2H5H255 H4-Cl-C6H4-CH(CH3) C2H5H256 H2-CH3-C6H4-CH(CH3) C2H5H257 H3-CH3-C6H4-CH(CH3) C2H5H258 H4-CH3-C6H4-CH(CH3) C2H5H259 H2-CF3-C6H4-CH(CH3) C2H5H260 H3-CF3-C6H4-CH(CH3) C2H5H261 H4-CF3-C6H4-CH(CH3) C2H5H262 H2-t-C4H9-C6H4-CH(CH3) C2H5H263 H3-t-C4H9-C6H4-CH(CH3) C2H5H264 H4-t-C4H9-C6H4-CH(CH3) C2H5H265 H2-CH3O-C6H4-CH(CH3)C2H5H266 H3-CH3O-C6H4-CH(CH3)C2H5H267 H4-CH3O-C6H4-CH(CH3)C2H5H268 H2-氰基-C6H4-CH(CH3) C2H5H269 H3-氰基-C6H4-CH(CH3) C2H5H270 H4-氰基-C6H4-CH(CH3) C2H5H271H2，4-Cl2-C6H3-CH(CH3)C2H5H272H 3，4-Cl2-C6H3-CH(CH3) C2H5H273H 3，5-Cl2-C6H3-CH(CH3) C2H5H274H 2，4-(CH3)2-C6H3-CH(CH3) C2H5H275H 2，5-(CH3)2-C6H3-CH(CH3) C2H5H276H CH3OOC-CH2C2H5H277H C2H5OOC-CH2C2H5H278H i-C3H7OOC-CH2C2H5H279H t-C4H9OOC-CH2C2H5H280H t-C4H9OOC-CH(CH3) C2H5H281H N≡C-CH2C2H5H282H C6H5CO-CH2C2H5H283H 吡啶-2-基-甲基 C2H5H284H 吡嗪-2-基-甲基 C2H5H285H 嘧啶-2-基-甲基 C2H5H286H 呋喃-2-基-甲基 C2H5H287H 吡咯-2-基-甲基 C2H5H288H N-甲基-吡咯-2-基-甲基 C2H5H289H 噻吩-2-基-甲基 C2H5H290H 异噁唑-5-基-甲基C2H5H291H 噻唑-2-基-甲基 C2H5H292H 噻唑-5-基-甲基 C2H5H293H 噁唑-2-基-甲基 C2H5H294H 吡唑-3-基-甲基 C2H5H295H 苯并呋喃-2-基-甲基 C2H5H296H 吲哚-2-基-甲基 C2H5H297H 吲哚-3-基-甲基 C2H5H298H 苯并噻唑-2-基-甲基 C2H5H299H 喹啉-2-基-甲基 C2H5H300H 4-Cl-C6H4OCH(CH3)-CH2C2H5H301CH3H C2H5H302CH3CH3C2H5H303CH3t-C4H9C2H5H304CH3CH2＝CH-CH2C2H5H305CH3CH2＝C(-Cl)-CH2C2H5H306CH3CH2＝C(CH3)-CH2C2H5H307CH3CH3CH＝CH-CH2C2H5H308CH3HC≡CCH2C2H5H309CH3CH3C≡C-CH2C2H5H310CH3环-C6H11C2H5H311CH3C6H5-CH2C2H5H332CH32-F-C6H4-CH2C2H5H313CH33-F-C6H4-CH2C2H5H314CH34-F-C6H4-CH2C2H5H316CH33-Cl-C6H4-CH2C2H5H317CH34-Cl-C6H4-CH2C2H5H318CH32-Br-C6H4-CH2C2H5H319CH33-Br-C6H4-CH2C2H5H320CH34-Br-C6H4-CH2C2H5H321CH32-CH3-C6H4-CH2C2H5H322CH33-CH3-C6H4-CH2C2H5H323CH34-CH3-C6H4-CH2C2H5H324CH32-CF3-C6H4-CH2C2H5H325CH33-CF3-C6H4-CH2C2H5H326CH34-CF3-C6H4-CH2C2H5H327CH32-i-C3H7-C6H4-CH2C2H5H328CH33-i-C3H7-C6H4-CH2C2H5H329CH34-i-C3H7-C6H4-CH2C2H5H330CH32-t-C4H9-C6H4-CH2C2H5H331CH33-t-C4H9-C6H4-CH2C2H5H332CH34-t-C4H9-C6H4-CH2C2H5H333CH32-CH3O-C6H4-CH2C2H5H334CH33-CH3O-C6H4-CH2C2H5H335CH34-CH3O-C6H4-CH2C2H5H336CH32-氰基-C6H4-CH2C2H5H337CH33-氰基-C6H4-CH2C2H5H338CH34-氰基-C6H4-CH2C2H5H339CH32-硝基-C6H4-CH2C2H5H340CH33-硝基-C6H4-CH2C2H5H341CH34-硝基-C6H4-CH2C2H5H342CH32，4-Cl2-C6H3-CH2C2H5H343CH33，4-Cl2-C6H3-CH2C2H5H344CH33，5-Cl2-C6H3-CH2C2H5H345CH32，6-Cl2-C6H3-CH2C2H5H346CH32，4-(CH3)2-C6H3-CH2C2H5H347CH32，5-(CH3)2-C6H3-CH2C2H5H348CH33，4-(CH3)2-C6H3-CH2C2H5H349CH33，5-(CH3)2-C6H3-CH2C2H5H350CH31-萘基-CH2C2H5H351CH32-萘基-CH2C2H5H352CH3C6H5-CH(CH3) C2H5H353CH32-Cl-C6H4-CH(CH3) C2H5H354CH33-Cl-C6H4-CH(CH3) C2H5H355CH34-Cl-C6H4-CH(CH3) C2H5H356CH32-CH3-C6H4-CH(CH3)C2H5H357CH33-CH3-C6H4-CH(CH3)C2H5H358CH34-CH3-C6H4-CH(CH3)C2H5H359CH32-CF3-C6H4-CH(CH3)C2H5H360CH33-CF3-C6H4-CH(CH3)C2H5H361CH34-CF3-C6H4-CH(CH3)C2H5H362CH32-t-C4H9-C6H4-CH(CH3)C2H5H363CH33-t-C4H9-C6H4-CH(CH3)C2H5H364CH34-t-C4H9-C6H4-CH(CH3)C2H5H365CH32-CH3O-C6H4-CH(CH3) C2H5H366CH33-CH3O-C6H4-CH(CH3) C2H5H367CH34-CH3O-C6H4-CH(CH3) C2H5H368CH32-氰基-C6H4-CH(CH3) C2H5H369CH33-氰基-C6H4-CH(CH3) C2H5H370CH34-氰基-C6H4-CH(CH3) C2H5H371CH32，4-Cl2-C6H3-CH(CH3)C2H5H372CH33，4-Cl2-C6H3-CH(CH3)C2H5H373CH33，5-Cl2-C6H3-CH(CH3)C2H5H374CH32，4-(CH3)2-C6H3-CH(CH3)C2H5H375CH32，5-(CH3)2-C6H3-CH(CH3)C2H5H376CH3CH3OOC-CH2C2H5H377CH3C2H5OOC-CH2C2H5H378CH3i-C3H7OOC-CH2C2H5H379CH3t-C4H9OOC-CH2C2H5H380CH3t-C4H9OOC-CH(CH3) C2H5H381CH3N≡C-CH2C2H5H382CH3C6H5CO-CH2C2H5H383CH3吡啶-2-基-甲基 C2H5H384CH3吡嗪-2-基-甲基 C2H5H385CH3嘧啶-2-基-甲基 C2H5H386CH3呋喃-2-基-甲基 C2H5H387CH3吡咯-2-基-甲基 C2H5H388CH3N-甲基-吡咯-2-基-甲基 C2H5H389CH3噻吩-2-基-甲基 C2H5H390CH3异噁唑-5-基-甲基 C2H5H391CH3噻唑-2-基-甲基 C2H5H392CH3噻唑-5-基-甲基 C2H5H393CH3噁唑-2-基-甲基 C2H5H394CH3吡唑-3-基-甲基 C2H5H395CH3苯并呋喃-2-基-甲基 C2H5H396CH3吲哚-2-基-甲基 C2H5H397CH3吲哚-3-基-甲基 C2H5H398CH3苯并噻唑-2-基-甲基 C2H5H399CH3喹啉-2-基-甲基 C2H5H400CH34-Cl-C6H4OCH(CH3)-CH2C2H5H401H H H CH3402H CH3H CH3403H t-C4H9H CH3404H CH2＝CH-CH2H CH3405H CH2＝C(-Cl)-CH2H CH3406H CH2＝C(CH3)-CH2H CH3407H CH3CH＝CH-CH2H CH3408H HC≡CCH2H CH3409H CH3C≡C-CH2H CH3410H 环-C6H11H CH3411H C6H5-CH2H CH3412H 2-F-C6H4-CH2H CH3413 H3-F-C6H4-CH2HCH3414 H4-F-C6H4-CH2HCH3415 H2-Cl-C6H4-CH2HCH3416 H3-Cl-C6H4-CH2HCH3417 H4-Cl-C6H4-CH2HCH3418 H2-Br-C6H4-CH2HCH3419 H3-Br-C6H4-CH2HCH3420 H4-Br-C6H4-CH2HCH3421 H2-CH3-C6H4-CH2HCH3422 H3-CH3-C6H4-CH2HCH3423 H4-CH3-C6H4-CH2HCH3424 H2-CF3-C6H4-CH2HCH3425 H3-CF3-C6H4-CH2HCH3426 H4-CF3-C6H4-CH2HCH3427 H2-i-C3H7-C6H4-CH2HCH3428 H3-i-C3H7-C6H4-CH2HCH3429 H4-i-C3H7-C6H4-CH2HCH3430 H2-t-C4H9-C6H4-CH2HCH3431 H3-t-C4H9-C6H4-CH2HCH3432 H4-t-C4H9-C6H4-CH2HCH3433 H2-CH3O-C6H4-CH2HCH3434 H3-CH3O-C6H4-CH2HCH3435 H4-CH3O-C6H4-CH2HCH3436 H2-氰基-C6H4-CH2HCH3437 H3-氰基-C6H4-CH2HCH3438 H4-氰基-C6H4-CH2HCH3439 H2-硝基-C6H4-CH2HCH3440 H3-硝基-C6H4-CH2HCH3441 H4-硝基-C6H4-CH2HCH3442 H2，4-Cl2-C6H3-CH2HCH3443 H3，4-Cl2-C6H3-CH2HCH3444 H3，5-Cl2-C6H3-CH2HCH3445 H2，6-Cl2-C6H3-CH2HCH3446 H2，4-(CH3)2-C6H3-CH2HCH3447 H2，5-(CH3)2-C6H3-CH2HCH3448 H3，4-(CH3)2-C6H3-CH2HCH3449 H3，5-(CH3)2-C6H3-CH2HCH3450 H1-萘基-CH2HCH3451 H2-萘基-CH2HCH3452 HC6H5-CH(CH3)HCH3453 H2-Cl-C6H4-CH(CH3) HCH3454 H3-Cl-C6H4-CH(CH3) HCH3455 H4-Cl-C6H4-CH(CH3) HCH3456 H2-CH3-C6H4-CH(CH3) HCH3457 H3-CH3-C6H4-CH(CH3) HCH3458 H4-CH3-C6H4-CH(CH3) HCH3459 H2-CF3-C6H4-CH(CH3) HCH3460 H 3-CF3-C6H4-CH(CH3) HCH3461 H 4-CF3-C6H4-CH(CH3) HCH3462 H 2-t-C4H9-C6H4-CH(CH3) HCH3463 H 3-t-C4H9-C6H4-CH(CH3) HCH3464 H 4-t-C4H9-C6H4-CH(CH3) HCH3465 H 2-CH3O-C6H4-CH(CH3)HCH3466 H 3-CH3O-C6H4-CH(CH3)HCH3467 H 4-CH3O-C6H4-CH(CH3)HCH3468 H 2-氰基-C6H4-CH(CH3) HCH3469 H 3-氰基-C6H4-CH(CH3) HCH3470 H 4-氰基-C6H4-CH(CH3) HCH3471 H 2，4-Cl2-C6H3-CH(CH3) HCH3472 H 3，4-Cl2-C6H3-CH(CH3) HCH3473 H 3，5-Cl2-C6H3-CH(CH3) HCH3474 H 2，4-(CH3)2-C6H3-CH(CH3) HCH3475 H 2，5-(CH3)2-C6H3-CH(CH3) HCH3476 H CH3OOC-CH2HCH3477 H C2H5OOC-CH2HCH3478 H i-C3H7OOC-CH2HCH3479 H t-C4H9OOC-CH2HCH3480 H t-C4H9OOC-CH(CH3)HCH3481 H N≡C-CH2HCH3482 H C6H5CO-CH2HCH3483 H 吡啶-2-基-甲基 HCH3484 H 吡嗪-2-基-甲基 HCH3485 H 嘧啶-2-基-甲基 HCH3486 H 呋喃-2-基-甲基 HCH3487 H 吡咯-2-基-甲基 HCH3488 H N-甲基-吡咯-2-基-甲基HCH3489 H 噻吩-2-基-甲基 HCH3490 H 异噁唑-5-基-甲基 HCH3491 H 噻唑-2-基-甲基 HCH3492 H 噻唑-5-基-甲基 HCH3493 H 噁唑-2-基-甲基 HCH3494 H 吡唑-3-基-甲基 HCH3495 H 苯并呋喃-2-基-甲基 HCH3496 H 吲哚-2-基-甲基 HCH3497 H 吲哚-3-基-甲基 HCH3498 H 苯并噻唑-2-基-甲基 HCH3499 H 喹啉-2-基-甲基 HCH3500 H 4-Cl-C6H4OCH(CH3)-CH2HCH3501 CH3HHCH3502 CH3CH3HCH3503 CH3t-C4H9HCH3504 CH3CH2＝CH-CH2HCH3505 CH3CH2＝C(-Cl)-CH2HCH3506 CH3C(CH3)-CH2HCH3507CH3CH3CH＝CH-CH2HCH3508CH3HC≡CCH2HCH3509CH3CH3C≡C-CH2HCH3510CH3环-C6H11HCH3511CH3C6H5-CH2HCH3512CH32-F-C6H4-CH2HCH3513CH33-F-C6H4-CH2HCH3514CH34-F-C6H4-CH2HCH3515CH32-Cl-C6H4-CH2HCH3516CH33-Cl-C6H4-CH2HCH3517CH34-Cl-C6H4-CH2HCH3518CH32-Br-C6H4-CH2HCH3519CH33-Br-C6H4-CH2HCH3520CH34-Br-C6H4-CH2HCH3521CH32-CH3-C6H4-CH2HCH3522CH33-CH3-C6H4-CH2HCH3523CH34-CH3-C6H4-CH2HCH3524CH32-CF3-C6H4-CH2HCH3525CH33-CF3-C6H4-CH2HCH3526CH34-CF3-C6H4-CH2HCH3527CH32-i-C3H7-C6H4-CH2HCH3528CH33-i-C3H7-C6H4-CH2HCH3529CH34-i-C3H7-C6H4-CH2HCH3530CH32-t-C4H9-C6H4-CH2HCH3531CH33-t-C4H9-C6H4-CH2HCH3532CH34-t-C4H9-C6H4-CH2HCH3533CH32-CH3O-C6H4-CH2HCH3534CH33-CH3O-C6H4-CH2HCH3535CH34-CH3O-C6H4-CH2HCH3536CH32-氰基-C6H4-CH2HCH3537CH33-氰基-C6H4-CH2HCH3538CH34-氰基-C6H4-CH2HCH3539CH32-Nitro-C6H4-CH2HCH3540CH33-Nitro-C6H4-CH2HCH3541CH34-Nitro-C6H4-CH2HCH3542CH32，4-Cl2-C6H3-CH2HCH3543CH33，4-Cl2-C6H3-CH2HCH3544CH33，5-Cl2-C6H3-CH2HCH3545CH32，6-Cl2-C6H3-CH2HCH3546CH32，4-(CH3)2-C6H3-CH2HCH3547CH32，5-(CH3)2-C6H3-CH2HCH3548CH33，4-(CH3)2-C6H3-CH2HCH3549CH33，5-(CH3)2-C6H3-CH2HCH3550CH31-萘基-CH2HCH3551CH32-萘基-CH2HCH3552CH3C6H5-CH(CH3) HCH3553CH32-Cl-C6H4-CH(CH3)HCH3554CH33-Cl-C6H4-CH(CH3) H CH3555CH34-Cl-C6H4-CH(CH3) H CH3556CH3CH3-C6H4-CH(CH3) H CH3557CH33-CH3-C6H4-CH(CH3)H CH3558CH34-CH3-C6H4-CH(CH3)H CH3559CH32-CF3-C6H4-CH(CH3)H CH3560CH33-CF3-C6H4-CH(CH3)H CH3561CH34-CF3-C6H4-CH(CH3)H CH3562CH32-t-C4H9-C6H4-CH(CH3)H CH3563CH33-t-C4H9-C6H4-CH(CH3)H CH3564CH34-t-C4H9-C6H4-CH(CH3)H CH3565CH32-CH3O-C6H4-CH(CH3) H CH3566CH33-CH3O-C6H4-CH(CH3) H CH3567CH34-CH3O-C6H4-CH(CH3) H CH3568CH32-氰基-C6H4-CH(CH3)H CH3569CH33-氰基-C6H4-CH(CH3)H CH3570CH34-氰基-C6H4-CH(CH3)H CH3571CH32，4-Cl2-C6H3-CH(CH3) H CH3572CH33，4-Cl2-C6H3-CH(CH3) H CH3573CH33，5-Cl2-C6H3-CH(CH3) H CH3574CH32，4-(CH3)2-C6H3-CH(CH3) H CH3575CH32，5-(CH3)2-C6H3-CH(CH3) H CH3576CH3CH3OOC-CH2H CH3577CH3C2H5OOC-CH2H CH3578CH3i-C3H7OOC-CH2H CH3579CH3t-C4H9OOC-CH2H CH3580CH3t-C4H9OOC-CH(CH3) H CH3581CH3N≡C-CH2H CH3582CH3C6H5CO-CH2H CH3583CH3吡啶-2-基-甲基 H CH3584CH3吡嗪-2-基-甲基 H CH3585CH3嘧啶-2-基-甲基 H CH3586CH3呋喃-2-基-甲基 H CH3587CH3吡咯-2-基-甲基 H CH3588CH3N-甲基-吡咯-2-基-甲基 H CH3589CH3噻吩-2-基-甲基 H CH3590CH3异噁唑-5-基-甲基H CH3591CH3噻唑-2-基-甲基 H CH3592CH3噻唑-5-基-甲基 H CH3593CH3噁唑-2-基-甲基 H CH3594CH3吡唑-3-基-甲基 H CH3595CH3苯并呋喃-2-基-甲基 H CH3596CH3吲哚-2-基-甲基 H CH3597CH3吲哚-3-基-甲基 H CH3598CH3苯并噻唑-2-基-甲基 H CH3599CH3喹啉-2-基-甲基 H CH3600CH34-Cl-C6H4OCH(CH3)-CH2H CH360lHH C2H5CH3602HCH3C2H5CH3603Ht-C4H9C2H5CH3604HCH2＝CH-CH2C2H5CH3605HCH2＝C(-Cl)-CH2C2H5CH3606HCH2＝C(CH3)-CH2C2H5CH3607HCH3CH＝CH-CH2C2H5CH3608HHC≡CCH2C2H5CH3609HCH3C≡C-CH2C2H5CH3610H环-C6H11C2H5CH3611HC6H5-CH2C2H5CH3612H2-F-C6H4-CH2C2H5CH3613H3-F-C6H4-CH2C2H5CH3614H4-F-C6H4-CH2C2H5CH3615H2-Cl-C6H4-CH2C2H5CH3616H3-Cl-C6H4-CH2C2H5CH3617H4-Cl-C6H4-CH2C2H5CH3618H2-Br-C6H4-CH2C2H5CH3619H3-Br-C6H4-CH2C2H5CH3620H4-Br-C6H4-CH2C2H5CH3621H2-CH3-C6H4-CH2C2H5CH3622H3-CH3-C6H4-CH2C2H5CH3623H4-CH3-C6H4-CH2C2H5CH3624H2-CF3-C6H4-CH2C2H5CH3625H3-CF3-C6H4-CH2C2H5CH3626H4-CF3-C6H4-CH2C2H5CH3627H2-i-C3H7-C6H4-CH2C2H5CH3628H3-i-C3H7-C6H4-CH2C2H5CH3629H4-i-C3H7-C6H4-CH2C2H5CH3630H2-t-C4H9-C6H4-CH2C2H5CH3631H3-t-C4H9-C6H4-CH2C2H5CH3632H4-t-C4H9-C6H4-CH2C2H5CH3633H2-CH3O-C6H4-CH2C2H5CH3634H3-CH3O-C6H4-CH2C2H5CH3635H4-CH3O-C6H4-CH2C2H5CH3636H2-氰基-C6H4-CH2C2H5CH3637H3-氰基-C6H4-CH2C2H5CH3638H4-氰基-C6H4-CH2C2H5CH3639H2-硝基-C6H4-CH2C2H5CH3640H3-硝基-C6H4-CH2C2H5CH3641H4-硝基-C6H4-CH2C2H5CH3642H2，4-Cl2-C6H3-CH2C2H5CH3643H3，4-Cl2-C6H3-CH2C2H5CH3644H3，5-Cl2-C6H3-CH2C2H5CH3645H2，6-Cl2-C6H3-CH2C2H5CH3646H2，4-(CH3)2-C6H3-CH2C2H5CH3647H2，5-(CH3)2-C6H3-CH2C2H5CH3648 H3，4-(CH3)2-C6H3-CH2C2H5CH3649 H3，5-(CH3)2-C6H3-CH2C2H5CH3650 H1-萘基-CH2C2H5CH3651 H2-萘基-CH2C2H5CH3652 HC6H5-CH(CH3) C2H5CH3653 H2-Cl-C6H4-CH(CH3) C2H5CH3654 H3-Cl-C6H4-CH(CH3) C2H5CH3655 H4-Cl-C6H4-CH(CH3) C2H5CH3656 H2-CH3-C6H4-CH(CH3) C2H5CH3657 H3-CH3-C6H4-CH(CH3) C2H5CH3658 H4-CH3-C6H4-CH(CH3) C2H5CH3659 H2-CF3-C6H4-CH(CH3) C2H5CH3660 H3-CF3-C6H4-CH(CH3) C2H5CH3661 H4-CF3-C6H4-CH(CH3) C2H5CH3662 H2-t-C4H9-C6H4-CH(CH3) C2H5CH3663 H3-t-C4H9-C6H4-CH(CH3) C2H5CH3664 H4-t-C4H9-C6H4-CH(CH3) C2H5CH3665 H2-CH3O-C6H4-CH(CH3) C2H5CH3666 H3-CH3O-C6H4-CH(CH3) C2H5CH3667 H4-CH3O-C6H4-CH(CH3) C2H5CH3668 H2-氰基-C6H4-CH(CH3)C2H5CH3669 H3-氰基-C6H4-CH(CH3)C2H5CH3670 H4-氰基-C6H4-CH(CH3)C2H5CH3671 H2，4-Cl2-C6H3-CH(CH3) C2H5CH3672 H3，4-Cl2-C6H3-CH(CH3) C2H5CH3673 H3，5-Cl2-C6H3-CH(CH3) C2H5CH3674 H2，4-(CH3)2-C6H3-CH(CH3) C2H5CH3675 H2，5-(CH3)2-C6H3-CH(CH3) C2H5CH3676 HCH3OOC-CH2C2H5CH3677 HC2H5OOC-CH2C2H5CH3678 Hi-C3H7OOC-CH2C2H5CH3679 Ht-C4H9OOC-CH2C2H5CH3680 Ht-C4H9OOC-CH(CH3) C2H5CH3681 HN≡C-CH2C2H5CH3682 HC6H5CO-CH2C2H5CH3683 H吡啶-2-基-甲基 C2H5CH3684 H吡嗪-2-基-甲基 C2H5CH3685 H嘧啶-2-基-甲基 C2H5CH3686 H呋喃-2-基-甲基 C2H5CH3687 H吡咯-2-基-甲基 C2H5CH3688 HN-甲基-吡咯-2-基-甲基 C2H5CH3689 H噻吩-2-基-甲基 C2H5CH3690 H异噁唑-5-基-甲基C2H5CH3691 H噻唑-2-基-甲基 C2H5CH3692 H噻唑-5-基-甲基 C2H5CH3693 H噁唑-2-基-甲基 C2H5CH3694 H吡唑-3-基-甲基 C2H5CH3695H 苯并呋喃-2-基-甲基C2H5CH3696H 吲哚-2-基-甲基C2H5CH3697H 吲哚-3-基-甲基C2H5CH3698H 苯并噻唑-2-基-甲基C2H5CH3699H 喹啉-2-基-甲基C2H5CH3700H 4-Cl-C6H4OCH(CH3)-CH2C2H5CH3701CH3H C2H5CH3702CH3CH3C2H5CH3703CH3t-C4H9C2H5CH3704CH3CH2＝CH-CH2C2H5CH3705CH3CH2＝C(-Cl)-CH2C2H5CH3706CH3CH2＝C(CH3)-CH2C2H5CH3707CH3CH3CH＝CH-CH2C2H5CH3708CH3HC≡CCH2C2H5CH3709CH3CH3C≡C-CH2C2H5CH3710CH3环-C6H11C2H5CH3711CH3C6H5-CH2C2H5CH3712CH32-F-C6H4-CH2C2H5CH3713CH33-F-C6H4-CH2C2H5CH3714CH34-F-C6H4-CH2C2H5CH3715CH32-Cl-C6H4-CH2C2H5CH3716CH33-Cl-C6H4-CH2C2H5CH3717CH34-Cl-C6H4-CH2C2H5CH3718CH32-Br-C6H4-CH2C2H5CH3719CH33-Br-C6H4-CH2C2H5CH3720CH34-Br-C6H4-CH2C2H5CH3721CH32-CH3-C6H4-CH2C2H5CH3722CH33-CH3-C6H4-CH2C2H5CH3723CH34-CH3-C6H4-CH2C2H5CH3724CH32-CF3-C6H4-CH2C2H5CH3725CH33-CF3-C6H4-CH2C2H5CH3726CH34-CF3-C6H4-CH2C2H5CH3727CH32-i-C3H7-C6H4-CH2C2H5CH3728CH33-i-C3H7-C6H4-CH2C2H5CH3729CH34-i-C3H7-C6H4-CH2C2H5CH3730CH32-t-C4H9-C6H4-CH2C2H5CH3731CH33-t-C4H9-C6H4-CH2C2H5CH3732CH34-t-C4H9-C6H4-CH2C2H5CH3733CH32-CH3O-C6H4-CH2C2H5CH3734CH33-CH3O-C6H4-CH2C2H5CH3735CH34-CH3O-C6H4-CH2C2H5CH3736CH32-氰基-C6H4-CH2C2H5CH3737CH33-氰基-C6H4-CH2C2H5CH3738CH34-氰基-C6H4-CH2C2H5CH3739CH32-硝基-C6H4-CH2C2H5CH3740CH33-硝基-C6H4-CH2C2H5CH3741CH34-硝基-C6H4-CH2C2H5CH3742CH32，4-Cl2-C6H3-CH2C2H5CH3743CH33，4-Cl2-C6H3-CH2C2H5CH3744CH33，5-Cl2-C6H3-CH2C2H5CH3745CH32，6-Cl2-C6H3-CH2C2H5CH3746CH32，4-(CH3)2-C6H3-CH2C2H5CH3747CH32，5-(CH3)2-C6H3-CH2C2H5CH3748CH33，4-(CH3)2-C6H3-CH2C2H5CH3749CH33，5-(CH3)2-C6H3-CH2C2H5CH3750CH31-萘基-CH2C2H5CH3751CH32-萘基-CH2C2H5CH3752CH3C6H5-CH(CH3) C2H5CH3753CH32-Cl-C6H4-CH(CH3) C2H5CH3754CH33-Cl-C6H4-CH(CH3) C2H5CH3755CH34-Cl-C6H4-CH(CH3) C2H5CH3756CH32-CH3-C6H4-CH(CH3) C2H5CH3757CH33-CH3-C6H4-CH(CH3) C2H5CH3758CH34-CH3-C6H4-CH(CH3) C2H5CH3759CH32-CF3-C6H4-CH(CH3) C2H5CH3760CH33-CF3-C6H4-CH(CH3) C2H5CH3761CH34-CF3-C6H4-CH(CH3) C2H5CH3762CH32-t-C4H9-C6H4-CH(CH3) C2H5CH3763CH33-t-C4H9-C6H4-CH(CH3) C2H5CH3764CH34-t-C4H9-C6H4-CH(CH3) C2H5CH3765CH32-CH3O-C6H4-CH(CH3) C2H5CH3766CH33-CH3O-C6H4-CH(CH3) C2H5CH3767CH34-CH3O-C6H4-CH(CH3) C2H5CH3768CH32-氰基-C6H4-CH(CH3)C2H5CH3769CH33-氰基-C6H4-CH(CH3)C2H5CH3770CH34-氰基-C6H4-CH(CH3)C2H5CH3771CH32，4-Cl2-C6H3-CH(CH3) C2H5CH3772CH33，4-Cl2-C6H3-CH(CH3) C2H5CH3773CH33，5-Cl2-C6H3-CH(CH3) C2H5CH3774CH32，4-(CH3)2-C6H3-CH(CH3) C2H5CH3775CH32，5-(CH3)2-C6H3-CH(CH3) C2H5CH3776CH3CH3OOC-CH2C2H5CH3777CH3C2H5OOC-CH2C2H5CH3778CH3i-C3H7OOC-CH2C2H5CH3779CH3t-C4H9OOC-CH2C2H5CH3780CH3t-C4H9OOC-CH(CH3) C2H5CH3781CH3N≡C-CH2C2H5CH3782CH3C6H5CO-CH2C2H5CH3783CH3吡啶-2-基-甲基 C2H5CH3784CH3吡嗪-2-基-甲基 C2H5CH3785CH3嘧啶-2-基-甲基 C2H5CH3786CH3呋喃-2-基-甲基 C2H5CH3787CH3吡咯-2-基-甲基 C2H5CH3788CH3N-甲基-吡咯-2-基-甲基 C2H5CH3789CH3噻吩-2-基-甲基 C2H5CH3790CH3异噁唑-5-基-甲基 C2H5CH3791CH3噻唑-2-基-甲基 C2H5CH3792CH3噻唑-5-基-甲基 C2H5CH3793CH3噁唑-2-基-甲基 C2H5CH3794CH3吡唑-3-基-甲基 C2H5CH3795CH3苯并呋喃-2-基-甲基 C2H5CH3796CH3吲哚-2-基-甲基 C2H5CH3797CH3吲哚-3-基-甲基 C2H5CH3798CH3苯并噻唑-2-基-甲基 C2H5CH3799CH3喹啉-2-基-甲基 C2H5CH3800CH34-Cl-C6H4OCH(CH3)-CH2C2H5CH3
表7 化合物编号R1R2R61H HH2H CH3H3H t-C4H9H4H CH2＝CH-CH2H5H CH2＝C(-Cl)-CH2H6H CH2＝C(CH3)-CH2H7H CH3CH＝CH-CH2H8H HC≡CH2H9H CH3C≡C-CH2H10 H 环-C6H11H11 H C6H5-CH2H12 H 2-F-C6H4-CH2H13 H 3-F-C6H4-CH2H14 H 4-F-C6H4-CH2H15 H 2-Cl-C6H4-CH2H16 H 3-Cl-C6H4-CH2H17 H 4-Cl-C6H4-CH2H18 H 2-Br-C6H4-CH2H19 H 3-Br-C6H4-CH2H20 H 4-Br-C6H4-CH2H21 H 2-CH3-C6H4-CH2H22 H 3-CH3-C6H4-CH2H23 H 4-CH3-C6H4-CH2H24 H 2-CF3-C6H4-CH2H25 H 3-CF3-C6H4-CH2H26 H 4-CF3-C6H4-CH2H27 H 2-i-C3H7-C6H4-CH2H28 H 3-i-C3H7-C6H4-CH2H29 H 4-i-C3H7-C6H4-CH2H30 H 2-t-C4H9-C6H4-CH2H31 H 3-t-C4H9-C6H4-CH2H32 H 4-t-C4H9-C6H4-CH2H33 H 2-CH3O-C6H4-CH2H34 H 3-CH3O-C6H4-CH2H35 H 4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH2H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3)H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3) H57H3-CH3-C6H4-CH(CH3) H58H4-CH3-C6H4-CH(CH3) H59H2-CF3-C6H4-CH(CH3) H60H3-CF3-C6H4-CH(CH3) H61H4-CF3-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3) H63H3-t-C4H9-C6H4-CH(CH3) H64H4-t-C4H9-C6H4-CH(CH3) H65H2-CH3O-C6H4-CH(CH3)H66H3-CH3O-C6H4-CH(CH3)H67H4-CH3O-C6H4-CH(CH3)H68H2-氰基-C6H4-CH(CH3) H69H3-氰基-C6H4-CH(CH3) H70H4-氰基-C6H4-CH(CH3) H71H2，4-Cl2-C6H3-CH(CH3) H72H3，5-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3) H81HN≡C-CH2H82HC6H5CO-CH2H83H 吡啶-2-基-甲基 H84H 吡嗪-2-基-甲基 H85H 嘧啶-2-基-甲基 H86H 呋喃-2-基-甲基 H87H 吡咯-2-基-甲基 H88H N-甲基-吡咯-2-基-甲基H89H 噻吩-2-基-甲基 H90H 异噁唑-5-基-甲基 H91H 噻唑-2-基-甲基 H92H 噻唑-5-基-甲基 H93H 噁唑-2-基-甲基 H94H 吡唑-3-基-甲基 H95H 苯并呋喃-2-基-甲基 H96H 吲哚-2-基-甲基 H97H 吲哚-3-基-甲基 H98H 苯并噻唑-2-基-甲基 H99H 喹啉-2-基-甲基 H100 H 4-Cl-C6H4OCH(CH3)-CH2H101 CH3HH102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3环-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128 CH33-i-C3H7-C6H4-CH2H129 CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3) H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3)H158CH34-CH3-C6H4-CH(CH3)H159CH32-CF3-C6H4-CH(CH3)H160CH33-CF3-C6H4-CH(CH3)H161CH34-CF3-C6H4-CH(CH3)H162CH32-t-C4H9-C6H4-CH(CH3)H163CH33-t-C4H9-C6H4-CH(CH3)H164CH34-t-C4H9-C6H4-CH(CH3)H165CH32-CH3O-C6H4-CH(CH3) H166CH33-CH3O-C6H4-CH(CH3) H167CH34-CH3O-C6H4-CH(CH3) H168CH32-氰基-C6H4-CH(CH3)H169CH33-氰基-C6H4-CH(CH3)H170CH34-氰基-C6H4-CH(CH3)H171CH32，4-Cl2-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3) H176CH3CH3OOC-CH2H177CH3C2H5OOC-CH2H178CH3i-C3H7OOC-CH2H179CH3t-C4H9OOC-CH2H180CH3t-C4H9OOC-CH(CH3)H181CH3N≡C-CH2H182CH3C6H5CO-CH2H183CH3吡啶-2-基-甲基 H184CH3吡嗪-2-基-甲基 H185CH3嘧啶-2-基-甲基 H186CH3呋喃-2-基-甲基 H187CH3吡咯-2-基-甲基 H188CH3N-甲基-吡咯-2-基-甲基H189CH3噻吩-2-基-甲基 H190CH3异噁唑-5-基-甲基 H191CH3噻唑-2-基-甲基 H192CH3噻唑-5-基-甲基 H193CH3噁唑-2-基-甲基 H194CH3吡唑-3-基-甲基 H195CH3苯并呋喃-2-基-甲基 H196CH3吲哚-2-基-甲基 H197CH3吲哚-3-基-甲基 H198CH3苯并噻唑-2-基-甲基 H199CH3喹啉-2-基-甲基 H200CH34-Cl-C6H4OCH(CH3)-CH2H201H H CH3202H CH3CH3203H t-C4H9CH3204H CH2＝CH-CH2CH3205H CH2＝C(-Cl)-CH2CH3206H CH2＝C(CH3)-CH2CH3207H CH3CH＝CH-CH2CH3208H HC≡CCH2CH3209H CH3C≡C-CH2CH3210H 环-C6H11CH3211H C6H5-CH2CH3212H 2-F-C6H4-CH2CH3213H 3-F-C6H4-CH2CH3214H 4-F-C6H4-CH2CH3215H 2-Cl-C6H4-CH2CH3216H 3-Cl-C6H4-CH2CH3217H 4-Cl-C6H4-CH2CH3218H 2-Br-C6H4-CH2CH3219H 3-Br-C6H4-CH2CH3220H 4-Br-C6H4-CH2CH3221H 2-CH3-C6H4-CH2CH3222H 3-CH3-C6H4-CH2CH3223H 4-CH3-C6H4-CH2CH3224H2-CF3-C6H4-CH2CH3225H3-CF3-C6H4-CH2CH3226H4-CF3-C6H4-CH2CH3227H2-i-C3H7-C6H4-CH2CH3228H3-i-C3H7-C6H4-CH2CH3229H4-i-C3H7-C6H4-CH2CH3230H2-t-C4H9-C6H4-CH2CH3231H3-t-C4H9-C6H4-CH2CH3232H4-t-C4H9-C6H4-CH2CH3233H2-CH3O-C6H4-CH2CH3234H3-CH3O-C6H4-CH2CH3235H4-CH3O-C6H4-CH2CH3236H2-氰基-C6H4-CH2CH3237H3-氰基-C6H4-CH2CH3238H4-氰基-C6H4-CH2CH3239H2-硝基-C6H4-CH2CH3240H3-硝基-C6H4-CH2CH3241H4-硝基-C6H4-CH2CH3242H2，4-Cl2-C6H3-CH2CH3243H3，4-Cl2-C6H3-CH2CH3244H3，5-Cl2-C6H3-CH2CH3245H2，6-Cl2-C6H3-CH2CH3246H2，4-(CH3)2-C6H3-CH2CH3247H2，5-(CH3)2-C6H3-CH2CH3248H3，4-(CH3)2-C6H3-CH2CH3249H3，5-(CH3)2-C6H3-CH2CH3250H1-萘基-CH2CH3251H2-萘基-CH2CH3252HC6H5-CH(CH3)CH3253H2-Cl-C6H4-CH(CH3) CH3254H3-Cl-C6H4-CH(CH3) CH3255H4-Cl-C6H4-CH(CH3) CH3256H2-CH3-C6H4-CH(CH3) CH3257H3-CH3-C6H4-CH(CH3) CH3258H4-CH3-C6H4-CH(CH3) CH3259H2-CF3-C6H4-CH(CH3) CH3260H3-CF3-C6H4-CH(CH3) CH3261H4-CF3-C6H4-CH(CH3) CH3262H2-t-C4H9-C6H4-CH(CH3) CH3263H3-t-C4H9-C6H4-CH(CH3) CH3264H4-t-C4H9-C6H4-CH(CH3) CH3265H2-CH3O-C6H4-CH(CH3)CH3266H3-CH3O-C6H4-CH(CH3)CH3267H4-CH3O-C6H4-CH(CH3)CH3268H2-氰基-C6H4-CH(CH3) CH3269H3-氰基-C6H4-CH(CH3) CH3270H4-氰基-C6H4-CH(CH3) CH3271H 2，4-Cl2-C6H3-CH(CH3) CH3272H 3，4-Cl2-C6H3-CH(CH3) CH3273H 3，5-Cl2-C6H3-CH(CH3) CH3274H 2，4-(CH3)2-C6H3-CH(CH3) CH3275H 2，5-(CH3)2-C6H3-CH(CH3) CH3276H CH3OOC-CH2CH3277H C2H5OOC-CH2CH3278H i-C3H7OOC-CH2CH3279H t-C4H9OOC-CH2CH3280H t-C4H9OOC-CH(CH3) CH3281H N≡C-CH2CH3282H C6H5CO-CH2CH3283H 吡啶-2-基-甲基 CH3284H 吡嗪-2-基-甲基 CH3285H 嘧啶-2-基-甲基 CH3286H 呋喃-2-基-甲基 CH3287H 吡咯-2-基-甲基 CH3288H N-甲基-吡咯-2-基-甲基 CH3289H 噻吩-2-基-甲基 CH3290H 异噁唑-5-基-甲基CH3291H 噻唑-2-基-甲基 CH3292H 噻唑-5-基-甲基 CH3293H 噁唑-2-基-甲基 CH3294H 吡唑-3-基-甲基 CH3295H 苯并呋喃-2-基-甲基 CH3296H 吲哚-2-基-甲基 CH3297H 吲哚-3-基-甲基 CH3298H 苯并噻唑-2-基-甲基 CH3299H 喹啉-2-基-甲基 CH3300H 4-Cl-C6H4OCH(CH3)-CH2CH3301CH3H CH3302CH3CH3CH3303CH3t-C4H9CH3304CH3CH2＝CH-CH2CH3305CH3CH2＝C(-Cl)-CH2CH3306CH3CH2＝C(CH3)-CH2CH3307CH3CH3CH＝CH-CH2CH3308CH3HC≡sCCH2CH3309CH3CH3C≡C-CH2CH3310CH3环-C6H11CH33311CH3C6H5-CH2CH3332CH32-F-C6H4-CH2CH3313CH33-F-C6H4-CH2CH3314CH34-F-C6H4-CH2CH3315CH32-Cl-C6H4-CH2CH3316CH33-Cl-C6H4-CH2CH3317CH34-Cl-C6H4-CH2CH3318CH32-Br-C6H4-CH2CH3319CH33-Br-C6H4-CH2CH3320CH34-Br-C6H4-CH2CH3321CH32-CH3-C6H4-CH2CH3322CH33-CH3-C6H4-CH2CH3323CH34-CH3-C6H4-CH2CH3324CH32-CF3-C6H4-CH2CH3325CH33-CF3-C6H4-CH2CH3326CH34-CF3-C6H4-CH2CH3327CH32-i-C3H7-C6H4-CH2CH3328CH33-i-C3H7-C6H4-CH2CH3329CH34-i-C3H7-C6H4-CH2CH3330CH32-t-C4H9-C6H4-CH2CH3331CH33-t-C4H9-C6H4-CH2CH3332CH34-t-C4H9-C6H4-CH2CH3333CH32-CH3O-C6H4-CH2CH3334CH33-CH3O-C6H4-CH2CH3335CH34-CH3O-C6H4-CH2CH3336CH32-氰基-C6H4-CH2CH3337CH33-氰基-C6H4-CH2CH3338CH34-氰基-C6H4-CH2CH3339CH32-硝基-C6H4-CH2CH3340CH33-硝基-C6H4-CH2CH3341CH34-硝基-C6H4-CH2CH3342CH32，4-Cl2-C6H3-CH2CH3343CH33，4-Cl2-C6H3-CH2CH3344CH33，5-Cl2-C6H3-CH2CH3345CH32，6-Cl2-C6H3-CH2CH3346CH32，4-(CH3)2-C6H3-CH2CH3347CH32，5-(CH3)2-C6H3-CH2CH3348CH33，4-(CH3)2-C6H3-CH2CH3349CH33，5-(CH3)2-C6H3-CH2CH3350CH31-萘基-CH2CH3351CH32-萘基-CH2CH3352CH3C6H5-CH(CH3) CH3353CH32-Cl-C6H4-CH(CH3) CH3354CH33-Cl-C6H4-CH(CH3) CH3355CH34-Cl-C6H4-CH(CH3) CH3356CH32-CH3-C6H4-CH(CH3)CH3357CH33-CH3-C6H4-CH(CH3)CH3358CH34-CH3-C6H4-CH(CH3)CH3359CH32-CF3-C6H4-CH(CH3)CH3360CH33-CF3-C6H4-CH(CH3)CH3361CH34-CF3-C6H4-CH(CH3)CH3362CH32-t-C4H9-C6H4-CH(CH3)CH3363CH33-t-C4H9-C6H4-CH(CH3)CH3364CH34-t-C4H9-C6H4-CH(CH3)CH3365CH32-CH3O-C6H4-CH(CH3)CH3366CH33-CH3O-C6H4-CH(CH3)CH3367CH34-CH3O-C6H4-CH(CH3)CH3368CH32-氰基-C6H4-CH(CH3) CH3369CH33-氰基-C6H4-CH(CH3) CH3370CH34-氰基-C6H4-CH(CH3) CH3371CH32，4-Cl2-C6H3-CH(CH3) CH3372CH33，4-Cl2-C6H3-CH(CH3) CH3373CH33，5-Cl2-C6H3-CH(CH3) CH3374CH32，4-(CH3)2-C6H3-CH(CH3) CH3375CH32，5-(CH3)2-C6H3-CH(CH3) CH3376CH3CH3OOC-CH2CH3377CH3C2H5OOC-CH2CH3378CH3i-C3H7OOC-CH2CH3379CH3t-C4H9OOC-CH2CH3380CH3t-C4H9OOC-CH(CH3)CH3381CH3N≡C-CH2CH3382CH3C6H5CO-CH2CH3383CH3吡啶-2-基-甲基 CH3384CH3吡嗪-2-基-甲基 CH3385CH3嘧啶-2-基-甲基 CH3386CH3呋喃-2-基-甲基 CH3387CH3吡咯-2-基-甲基 CH3388CH3N-甲基-吡咯-2-基-甲基CH3389CH3噻吩-2-基-甲基 CH3390CH3异噁唑-5-基-甲基 CH3391CH3噻唑-2-基-甲基 CH3392CH3噻唑-5-基-甲基 CH3393CH3噁唑-2-基-甲基 CH3394CH3吡唑-3-基-甲基 CH3395CH3苯并呋喃-2-基-甲基 CH3336CH3吲哚-2-基-甲基 CH3397CH3吲哚-3-基-甲基 CH3398CH3苯并噻唑-2-基-甲基 CH3399CH3喹啉-2-基-甲基 CH3400CH34-Cl-C6H4OCH(CH3)-CH2CH3
本发明的式I所示新颖化合物适于用作杀真菌剂。
本发明新颖化合物或含有它们的组合物例如可以下述剂型应用可直接喷洒的溶液，颗粒，悬浮液(包括高浓度的水性、油性或其它悬浮液)，分散剂，乳剂，油性分散剂，糊剂，粉剂，撒播剂或颗粒剂，用喷洒、雾化、喷粉、播撒或浇灌来使用。根据使用的目的指导应用的剂型；但无论哪种情况都要尽可能地将本发明活性成分分散开使用。
通常是将活性化合物喷洒或喷粉到植物上或用活性化合物处理植物的种子。
各种制剂按照已知方法制备，例如用溶剂和/或载体稀释，如需要，还可使用乳化剂和分散剂，在用水作为稀释剂时、也可用其它有机溶剂作为助溶剂。助溶剂主要可考虑用芳烃溶剂(例如二甲苯)，氯代芳烃(如氯苯)，脂烃(如石油馏份)，醇类(如甲醇、丁醇)，酮类(如环己酮)，胺类(如乙醇胺、二甲基甲酰胺)和水；载体如天然矿石粉(如高岭土，粘土，滑石粉，白垩粉)和合成的无机物粉(如高度分散的硅酸、硅酸盐)；乳化剂如非离子型和阴离子型乳化剂(例如聚氧乙烯—脂肪醇醚，烷基磺酸盐和芳基磺酸盐)；分散剂如木质素—亚硫酸废液和甲基纤维素。
表面活性剂可考虑用芳香磺酸例如木质素—、酚—、萘—、和二丁基萘—磺酸的碱金属盐、碱土金属盐、铵盐，以及脂肪酸盐，烷基—和烷芳基磺酸盐，烷基—、十二烷醚基—和脂肪醇基—硫酸盐，以及十六、十七和十八醇的硫酸单酯盐，脂肪醇乙二醇醚的盐，磺酸化萘及其衍生物与甲醛的缩合产物，萘或萘磺酸与苯酚和甲醛的缩合产物，聚氧乙烯辛基酚醚，乙氧基化的异辛基—、辛基或壬基酚，烷基酚—聚二醇醚或三丁苯基聚乙二醇醚，烷芳基聚醚醇，异十三碳醇，脂醇—环氧乙烷缩合物，乙氧基化的蓖麻油，聚氧乙烯烷基醚，聚氧丙烯，十二烷醇聚二醇醚乙酸酯，山梨醇酯，木质素—亚硫酸废液或甲基纤维素。
颗粒、粉剂和撒播剂的制备方法是将活性成分与固体载体混合或共同研磨。
颗粒剂，例如覆盖型颗粒、浸渍型颗粒和均匀型颗粒剂可将活性成分与固体载体结合而制备。固体载体物质是矿土如硅胶、硅酸、硅胶、硅酸盐、滑石、高岭土、石灰石、石灰、白垩土、红玄武土、黄土、陶土、白云石、硅藻土、硫酸钙和镁、氧化镁、磨细的塑料和肥料如硫酸铵、磷酸铵、硝酸铵和脲，植物制品，如谷粉、树皮粉、木材粉和坚果壳粉、纤维素粉，或其它固体载体。
这些制剂的示例为I.90重量份表1中的化合物2(即1/2)和10重量份N—甲基—α—吡咯烷酮的溶液，它适于以很细的液滴的形式使用；II.20重量份表1中的化合物36(即1/36)、80重量份二甲苯、10重量份8—10摩尔环氧乙烷加合到1摩尔N—羟乙基油酰胺上的产物、5重量份十二烷基苯磺酸钙、5重量份40摩尔环氧乙烷加合到1摩尔蓖麻油上的产物的混合物，将该溶液精细分散到水中得到一分散体；III.20重量份化合物1/49、40重量份环己酮、30重量份异丁醇和20重量份40摩尔环氧乙烷加合到1摩尔蓖麻油上的产物的水分散体；IV.20重量份化合物1/58、25重量份环己醇、65重量份沸程为210—280℃的矿物油级分和10重量份40摩尔环氧乙烷加合到1摩尔蓖麻油上的产物的水分散体；V.80重量份化合物1/2、3重量份二异丁基萘—α—磺酸钠、10重量份得自亚硫酸废液的木质素磺酸的钠盐和7重量份硅胶颗粒的混合物在锤磨机中研磨，将该混合物精细分散于水中，得到喷洒用液；VI.3重量份化合物1/36和97重量份细粉高岭土的紧密掺合物，该撒粉组合物含有3％wt活性化合物；VII.30重量份化合物1/49、92重量份硅胶颗粒和8重量份喷洒到硅胶颗粒表面上的石蜡油的紧密掺合物，该制剂使活性化合物能很好地粘附；VIII.40重量份化合物1/58、10重量份酚磺酸钠—脲—甲醛缩聚物、2重量份硅胶和48重量份水的稳定水分散体，它可以进一步稀释；IX.20重量份化合物1/20、2重量份十二烷基苯磺酸钙、8重量份脂肪醇—聚二醇醚、20重量份酚磺酸钠—脲—甲醛缩合物和68重量份直链矿物油的稳定油分散体。
本发明新颖化合物对植物病理性真菌有优异和广谱的作用，尤其是对于囊菌属和担子菌属。它们部分可系统地起作用，并可用作叶片和土壤中的杀真菌剂。
它们对各种浓作物及其种子上的多种真菌的杀灭作用特别有意义，特别是对小麦、黑麦、大麦、燕麦、水稻、玉米、草、棉花、大豆、咖啡、甘蔗、葡萄、水果植物、观赏植物和蔬菜如黄瓜、豆角、南瓜类植物。
使用本化合物时是用对真菌有效量的化合物处理被保护的种子、植物、物料或土壤，使其免受真菌的侵害。
这些化合物可在物料、植物或种子被真菌感染前或感染后使用。
本发明新颖化合物特别适于防治如下的植物病害粮食中的麦类白粉菌，南瓜类值物中的瓜类白粉菌和黄瓜白粉病球壳霉，苹果中的白丝足球霉，葡萄中的葡萄白粉病钩丝壳霉，粮食作物中的双孢锈菌属，棉花和草中的丝核菌属，粮食作物和甘蔗中的黑粉菌属，苹果的苹果黑星病菌，粮食作物的长蠕孢属，小麦的颖斑枯病壳针孢霉，草莓和葡萄的灰缘葡萄孢，花生的褐斑病菌，小麦和大麦的假小白尾孢，水稻的Pyricularia oryzae，马铃薯和番茄的疫霉，各种植物的镰刀霉属和轮枝孢菌属，葡萄的霜霉菌，蔬菜和水果的交链孢霉。
该新的化合物也可用于材料防护(木材防护)，例如防治拟青霉。
该杀真菌剂组合物通常含活性化合物0.1—95％(重量％)，优选为0.5～90％(重量％)。
本发明的化合物用量根据所需达到的效果每公顷用0.02～3kg活性化合物。
用于种子处理的用量为每公斤种子用活性化合物0.001～50g，优选为0.01～10g。
用作杀真菌剂的本发明化合物还可与其它活性化合物一起使用，例如与除草剂、杀虫剂、生长调节剂、杀真菌剂或化肥一起使用。
与杀真菌剂混合时，在很多情况下可以拓宽杀真菌活性的谱。
下列杀真菌剂可与本发明化合物一起组合使用(应注意这只是举例说明，并非穷举)硫，二硫代氨基甲酸盐及它们的衍生物，如二甲基二硫代氨基甲酸亚铁、二甲基二硫代氨基甲酸锌、亚乙基双二硫代氨基甲酸锌、亚乙基双二硫代氨基甲酸锰、亚乙基双二硫代氨基甲酸锰锌、二硫化四甲基秋兰姆、N，N’—亚乙基双二硫代氨基甲酸锌的氨配合物、N，N’—亚丙基双二硫代氨基甲酸锌的氨配合物、N，N’—多亚丙基双(硫代氨基甲酰基)二硫化物，硝基衍生物，如巴豆酸二硝基(1—甲基庚基)苯酯、3，3—二甲基丙烯酸2—仲丁基—4，6—二硝基苯酯、异丙基碳酸2—仲丁基—4，6—二硝基苯酯、5—硝基间苯二甲酸二异丙酯，杂环化合物，如2—十七烷基—2—咪唑啉乙酸酯、2，4—二氯—6—(邻氯苯氨基)—S—三嗪、苯二甲酰亚氨基硫代膦酸二乙酯、5—氨基—1—β—双(二甲基氨基)氧膦基—3—苯基—1，2，4—三唑、2，3—二氰基—1，4—二硫代蒽醌、2—硫代—1，3—二硫代环戊二烯基β4，5—b’喹喔啉、1—(丁基氨基甲酰基)—2—苯并咪唑氨基甲酸甲酯、2—甲氧羰基氨基苯并咪唑、2—(2—呋喃基)苯并咪唑、2—(4—噻唑基)苯并咪唑、N—(1，1，2，2—四氯乙硫基)四氢苯二甲酰亚胺、N—三氯甲硫基四氢苯二甲酰亚胺、N—三氯甲硫基苯二甲酰亚胺，N—二氯一氟甲硫基—N’，N’—二甲基—N—苯基硫酸二酰胺，5—乙氧基—3—三氯甲基—1，2，3—噻二唑，2—硫氰基甲硫基苯并噻唑，1，4—二氯—2，5—二甲氧基苯，4—(2—氯苯基亚肼基)—3—甲基—5—异恶唑酮，吡啶—2—硫代—1—氧化物，8—羟基喹啉或其酮盐，2，3—二氢—5—羧酰苯胺基—6—甲基—1，4—氧硫杂环己二烯，2，3—二氢—5—羧酰苯胺基—6—甲基—1，4—氧硫杂环己二烯—4，4—二氧化物，2—甲基—5，6—二氢—4H—吡喃—3—羧酰苯胺，2—甲基呋喃—3—羧酰苯胺，2，5—二甲基呋喃—3—羧酰苯胺，2，4，5—三甲基呋喃—3—羧酰苯胺，N—环己基—2，5—二甲基呋喃—3—羧酰胺，N—环己基—N—甲氧基—2，5—二甲基呋喃—3—羧酰胺，2—甲基苯甲酰苯胺，
2—磺苯甲酰苯胺，N—甲酰基—N—吗啉—2，2，2—三氯乙基缩醛，哌嗪—1，4—二基双[1—(2，2，2—三氯乙基)甲酰胺]1—(3，4—二氯苯氨基)—1—甲酰氨基—2，2，2—三氯乙烷，2，6—二甲基—N—十三烷基吗啉或其盐，2，6—二甲基—N—环十二烷基吗啉或其盐，N—(3—对叔丁基苯基—2—甲基—丙基)—顺—2，6—二甲基吗啉，N—(3—对叔丁基苯基—2—甲基—丙基)—哌啶，1—[2—(2，4—二氯苯基)—4—乙基—1，3—二氧戊环—2—基乙基]—1H—1，2，4—三唑，1—[2—(2，4—二氯苯基)—4—正丙基—1，3—二氧戊环—2—基乙基]—1H—1，2，4—三唑，N—正丙基—N—(2，4，6—三氯苯氧基乙基)—N’—咪唑基脲，1—(4—氯苯氧基)—3，3—二甲基—1—(1H—1，2，4—三唑—1—基)—2—丁酮，α—(2—氯苯基)—α—(4—氯苯基)—5—嘧啶甲醇，5—丁基—2—二甲基氨基—4—羟基—6—甲基嘧啶，双(对氯苯基)—3—吡啶甲醇，1，2—双(3—乙氧羰基—2—硫脲基)苯，1，2—双(3—甲氧羰基—2—硫脲基)苯，以及各种杀真菌剂，如乙酸十二烷基胍，
3—[3—(3，5—二甲基—2—氧基环己基)—2—羟乙基)]戊二酰亚胺，六氯苯，DL—甲基—N—(2，6—二甲基苯基)—N—2—糠酰基的丙氨酸酯，DL—N—(2，6—二甲基苯基)—N—(2’—甲氧基乙酰基)丙氨酸甲酯，N—(2，6—二甲基苯基)—N—氯乙酰基—D，L—2—氨基丁内酯，DL—N—(2，6—二甲基苯基)—N—苯乙酰基丙氨酸甲酯，5—甲基—5—乙烯基—3—(3，5—二氯苯基)—2，4—二氧代—1，3—噁唑烷，3—[3，5—二氯苯基(—5—甲基—5—甲氧甲基]—1，3—噁唑烷—2，4—二酮，3—(3，5—二氯苯基)—1—异丙基甲氨酰基海因，N—(3，5—二氯苯基)—1，2—二甲基环丙烷—1，2—二羧酰胺，2—氰基—(N—乙基氨基甲酰基—2—甲氧亚氨基]乙酰胺，1—[2—(2，4—二氯苯基)戊基]—1H—1，2，4—三唑，2，4—二氟—α—(1H—1，2，4—三唑基甲基)二苯甲基醇，N—(3—氯—2，6—二硝基—4—三氟甲基苯基)—5—三氟甲基—3—氯—2—氨基吡啶，1—[(双(4—氟苯基)甲基甲硅烷基)甲基]—1H—1，2，4—三唑。
应用实施例2—(甲氧亚氨基—O—[(3—三氟甲基苯基)甲基]苯基乙醛酸甲酯O—甲基肟(A)和2—(甲氧亚氨基—O—[(3—溴苯基)甲基]苯基乙醛酸甲酯0—甲基肟(B)[两者均在EP 499 823中公开]用作对比活性化合物。
应用实施例1防治葡萄生单轴霉的活性用含有80％活性化合物和20％乳化剂(以干重计)的水喷洒液喷到盆栽葡萄(变种Muller Thurgau)的叶子上。为了评价活性化合物作用的有效期。在喷液干燥后，使这些植物在温室中呆8天。然后用葡萄生单轴霉的游动孢子悬浮液感染这些叶子。然后，先使这些葡萄在水蒸汽饱和的24℃的室中呆48小时，随后在20℃—30℃的温室中呆5天。然后再让这些植物在上述潮湿室中呆16小时，然后评价叶子底部发生病害的程度。
在这个试验中，含16ppm化合物(表/编号)1/32、1/34、1/49、1/58、1/114、1/128、1/134、1/145和1/155的配方处理过的叶子只有15％或更少发生病害，而未处理的植物有高达70％发生病害。含16ppm已知活性化合物A和B的配方处理的植物有高达35％的发生病害。
应用实施例2防治大麦网斑病菌的活性用含有80％活性化合物和20％乳化剂(以干重计)的水悬浮液喷洒两叶期的大麦幼苗(变种Igri)，直至滴湿。24小时后，用大麦网斑病菌的孢子悬浮液感染这些植物，并在18℃、高湿度室中放置48小时。然后将这些植物在相对湿度为70％的20℃—22℃的温室中再培养5天。然后评价叶片发生病害的程度。
结果表明，用作含63ppm或16ppm活性化合物的喷哂液时与已知的对比活性合物A和B(50％叶子发生病害)相比，活性化合物(表/编号)1/49和1/58(5％或15％叶子发生病害)表现出更好的杀真菌活性。
应用实施例3防治小麦上的大刀镰孢的活性用含有80％活性化合物和20％乳化剂(以干重计)的含水喷液喷洒盆栽小麦(变种Kanzler)的初生叶。第二天，用大刀镰孢的孢子悬浮液接种这些植物，然后在高温度(＞90％)的培养室(22—24℃)中培养。6天后，肉眼观察评价病害症状的发展情况。
在这个试验中，用含500ppm化合物(表/编号)1/8、1/23、1/28、1/29、1/32、1/34、1/35、1/36、1/37、1/58、1/71、1/83、1/114和1/128的制剂处理过的植物有15％或更少发生病害，未处理的植物高达80％发生病害。用含500ppm已知活性化合物A和B的制剂处理的植物分别有80％或60％发生病害。
权利要求
1.式I所示的化合物 式中取代基的意义如下Y是氧原子或基团NR6；Z1和Z2相互独立地为氢原子、卤原子、烷基、链烯基、链炔基、烷氧基、链烯基氧基、卤代烷基、卤代烷氧基、卤代链烯基氧基、氰基或硝基；R1是氢原子、烷基、卤代烷基或芳基；R2是氢原子，或者未取代或取代的烷基、链烯基、链炔基、环烷基、杂芳基烷基、杂环基、环烯基、芳烷基、芳基、杂芳基、芳基链烯基、杂芳基链烯基、芳氧基烷基、杂芳氧基烷基、酰基、芳基羰基、杂芳基羰基或烷氧羰基；R3、R4、R5和R6相互独立地为氢原子或烷基；或者R6和R2同与它们相连的氮原子一起形成环。
2.含有惰性载体和杀真菌活性量的权利要求1式1化合物的杀真菌剂。
3.一种防治真菌病害的方法，它包括用杀真菌活性量权利要求1的式I化合物处理真菌或被真菌侵害的材料、植物、种子或土壤。
4.权利要求1的式I化合物的制备方法，它包括使式II所示酯(式中的R7为烷基) 与式III所示胺或氨反应
5.式中的R5为氢原子的权利要求1的式I化合物的制备方法，它包括使式VI所示醛缩一胺与式VII所示羰基化合物的混合物 与式VIII所示羟胺或肼衍生物(Y为O，NR6)或它们的一种酸加合盐反应R2—Y—NH2(VIII)
6.权利要求9中的式VI化合物。
7.权利要求5中的式VI化合物的制备方法，它包括使式IV所示的酯(R7为烷基) 与式V所示伯胺反应 H2N-R4(V)
8.权利要求5的式VI化合物—式中的R1为H—的制备方法，它包括将式X所示单烷基(α—烷氧亚氨基苯乙酰胺—式中的R3为烷基 转化成含有两个金属基的金属化产品，并使该金属化产品与式XII所示羧酸衍生物反应 (X＝Cl、OCOR7或OR7，R7为烷基或芳基)。
9.权利要求5中的式VI所示化合物的制备方法，它包括将权利要求7中的式X所示单烷基α—烷氧亚氨基苯乙酰胺(式中R3为烷基)转化成含有两个金属基的金属化产品，并使该金属化产品与式XIII所示醛反应， 并氧化形成的式XIV所示醇
10.权利要求7中的式X所示化合物，其中，R3和R4是烷基。
11.权利要求8中的式XIV所示化合物，其中，R3和R4是烷基，并且R1同权利要求1中的定义。
全文摘要
本发明公开了式I所示的化合物式中取代基的意义如下Y是氧原子或基团NRZRRR或者R
文档编号A01N25/30GK1120333SQ94191640
公开日1996年4月10日 申请日期1994年3月19日 优先权日1993年3月29日
发明者R·多特泽, W·格拉梅诺斯, H·索特, A·哈罗伊斯, H·温格特, E·安默曼, G·洛伦兹 申请人:巴斯福股份公司