取代的吡啶除草剂的制作方法

专利名称：取代的吡啶除草剂的制作方法
技术领域：
本发明涉及具有除草活性的新型吡啶酮化合物、其制备、包含这些化合物的组合物以及它们在防治杂草，尤其是防治有用作物中的杂草方面和抑制植物生长方面的用途。
具有除草活性的吡啶酮化合物在例如WO97/46530中已有记载。但现在我们发现了新的具有除草和生长抑制性能的吡啶酮化合物。
因此，本发明涉及式I化合物及其农药上可耐受的盐M+以及式I化合物的所有立体异构体和互变异构体 其中p为0或1；R5为C1-C6卤代烷基；R2为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，被C1-C2烷氧基羰基或苯基取代的乙烯基，或者为C2-C6炔基，C2-C6卤代炔基，被三甲基甲硅烷基、羟基、C1-C2烷氧基、C1-C2烷氧基羰基或苯基取代的乙炔基，或者为C3-C6二烯基(allenyl)，C3-C6环烷基，被卤素取代的C3-C6环烷基，或者为C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6卤代烷氧基，C3-C6卤代链烯氧基，氰基-C1-C4烷氧基，C1-C4烷氧基-C1-C4烷氧基，C1-C4烷硫基-C1-C4烷氧基，C1-C4烷基亚磺酰基-C1-C4烷氧基，C1-C4烷基磺酰基-C1-C4烷氧基，C1-C4烷氧基羰基-C1-C4烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C4烷氧基羰基-C1-C4烷硫基，C1-C4烷氧基羰基-C1-C4烷基亚磺酰基，C1-C4烷氧基羰基-C1-C4烷基磺酰基，苄基-S(O)n1-，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，二-(C1-C6烷基氨基)磺酰基，苄氧基，苄基，苯基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，这些含苯基的基团本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者R2为OS(O)n2-R21，N(R23)-S(O)n3-R22，氰基，氨基甲酰基，C1-C4烷氧基羰基，甲酰基，卤素，氰硫基，氨基，羟基-C1-C4烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C6烷基羰氧基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4烷氧基羰氧基-C1-C4烷基，C1-C4氰硫基-C1-C4烷基，苯甲酰氧基-C1-C4烷基，C2-C6环氧乙烷基(oxiranyl)，C1-C4烷基氨基-C1-C4烷基，二-(C1-C4烷基)氨基-C1-C4烷基，C1-C12烷基硫代羰基-C1-C4烷基或甲酰基-C1-C4烷基，或者R2为可以是芳香性或部分饱和并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2SO-、或-CH2SO2基团与吡啶环键连，且每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；R3为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6二烷基氨基磺酰基，苯基，苯硫基，苯基亚磺酰基，苯磺酰基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者R3为-N(R23)-S(O)n-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基或C1-C4烷基-S(O)n-C1-C4烷基；R4为氢，C1-C6烷基，羟基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6卤代链烯氧基，C3-C6炔氧基，C1-C4烷基羰氧基，C1-C4烷基磺酰氧基，甲苯磺酰氧基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，C1-C4烷基氨基，C1-C4二烷基氨基，C1-C4烷氧基羰基，C1-C4卤代烷基，甲酰基，氰基，卤素，苯基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代；或者R4为可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或R3-稠合二环环系，其中所述环系，除非稠合，均直接或经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2S-、-CH2SO-、或-CH2SO2-基团与吡啶环键连，且所述环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C1-C4烷氧基-C1-C2烷硫基，C1-C4烷基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷硫基，氰基-C1-C4烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；R21为C1-C4烷基或C1-C4卤代烷基；R22为C1-C4烷基，C1-C4卤代烷基或二-(C1-C4烷基)氨基；R23、R24、R25彼此独立地为氢或C1-C4烷基；n，n1，n2，n3和n4彼此独立地为0，1或2；Q为Q1 其中R6、R7、R8和R9彼此独立地为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6炔基，C1-C6烷氧基羰基，C1-C6烷基羰基，C1-C6烷基-S(O)n17，C1-C6烷基-NHS(O)2，C1-C6烷基氨基，二-(C1-C6烷基)氨基，羟基，C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，羟基-C1-C6烷基，C1-C4烷基磺酰氧基-C1-C6烷基，甲苯磺酰氧基-C1-C6烷基，C1-C6烷氧基-C1-C6烷基，C1-C6烷基-S(O)n4-C1-C6烷基，氰基-C1-C6烷基，C1-C6烷氧基-C1-C6烷氧基，苄氧基-C1-C6烷基，C1-C6烷氧基羰基-C1-C6烷基，C1-C6烷氧基羰氧基-C1-C6烷基，氰硫基-C1-C6烷基，环氧乙烷基，C1-C6烷基氨基-C1-C6烷基，二(C1-C6烷基)氨基-C1-C6烷基，甲酰基-C1-C6烷基，C1-C6烷基肟基(alkyloximo)，卤素，氰基，硝基，苯基或被下列基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n18、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n5、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n19N(C1-C4烷基)2、卤素、硝基、COOH或氰基；或者相邻的R6与R7或R8与R9一起表示-(CH2)m-，C(O)O(CH2)n20-或-S(O)n21(CH2)n22-；n5，n17，n18，n19和n21彼此独立地为0，1或2；n20为2或3；n22为2，3或4；m为2，3，4，5，或6；W为氧，S(O)n6，-CR11R12-，-CR63R64CR65R66，-C(O)-或-NR13；R63、R64、R65和R66彼此独立地为氢或C1-C6烷基，或者R65与R7或R9一起形成直接键；n6为0，1或2；R11为氢，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基，C1-C4烷硫基-C3-C6环烷基，C1-C4烷基羰氧基-C1-C4烷基，C1-C4烷基磺酰氧基-C1-C4烷基，甲苯磺酰氧基-C1-C4烷基，二-(C1-C3烷氧基烷基)甲基，二-(C1-C3烷硫基烷基)甲基，(C1-C3烷氧基烷基)-(C1-C3烷硫基烷基)甲基，C3-C5氧杂环烷基，C3-C5硫杂环烷基，C3-C4二氧杂环烷基，C3-C4二硫杂环烷基，C3-C4氧硫杂环烷基，甲酰基，C1-C4烷氧基羰基，氨基甲酰基，C1-C4烷基氨基羰基，二-(C1-C4烷基)氨基羰基，苯基氨基羰基，苄基氨基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n21、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n7、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n20N(C1-C4烷基)、卤素、硝基、COOH或氰基；n7，n20和n21彼此独立地为0，1或2；或者R12与R6或R9一起代表基团-(CH2)o-；o为1，2，3，4或5；R12为氢，C1-C4烷基或C1-C4卤代烷基；或者R12与R11一起代表基团-(CH2)m1；m1为2，3，4，5，或6；R10为羟基，O-M+，卤素，氰基，SCN，OCN，C1-C12烷氧基，C1-C4烷氧基羰基-C1-C4烷氧基，C1-C12烷硫基，C1-C12烷基亚磺酰基，C1-C12烷基磺酰基，C1-C12卤代烷硫基，C1-C12卤代烷基亚磺酰基，C1-C12卤代烷基磺酰基，C1-C6烷氧基-C1-C6烷硫基，C1-C6烷氧基-C1-C6烷基亚磺酰基，C1-C6烷氧基-C1-C6烷基磺酰基，C2-C12链烯硫基，C2-C12链烯基亚磺酰基，C2-C12链烯基磺酰基，C2-C12炔硫基，C2-C12炔基亚磺酰基，C2-C12炔基磺酰基，C2-C12卤代链烯硫基，C2-C12卤代链烯基亚磺酰基，C2-C12卤代链烯基磺酰基，C1-C4烷氧基羰基-C1-C4烷硫基，C1-C4烷氧基羰基-C1-C4烷基亚磺酰基，C1-C4烷氧基羰基-C1-C4烷基磺酰基，(C1-C4烷氧基)2P(O)O，C1-C4烷基-(C1-C4烷氧基)P(O)O，H(C1-C4烷氧基)P(O)O，R14R15N，R14R15NNH，R16R17NC(O)O-，R16R17NC(O)NH-，C1-C12烷基-S(O)2NR18，C1-C4卤代烷基-S(O)2NR19，C1-C12烷基-S(O)2O，C1-C4卤代烷基-S(O)2O，C1-C18烷基羰氧基，其中的烷基基团可以被卤素、C1-C6烷氧基、C1-C6烷硫基或氰基取代，或者为C2-C18链烯基羰氧基，C2-C18炔基羰氧基，C3-C6环烷基羰氧基，C1-C12烷氧基羰氧基，C1-C12烷硫基羰氧基，C1-C12烷基硫代氨基甲酰基，C1-C6烷基-NH(CS)N(C1-C6烷基)-NH-，二-C1-C6烷基-N(CS)N(C1-C6烷基)-NH-，苄氧基，苄硫基，苄基亚磺酰基，苄基磺酰基，苯氧基，苯硫基，苯基亚磺酰基，苯基磺酰基，苯磺酰基氨基，苯磺酰氧基或苯甲酰氧基，其中的苯基基团部分本身又可被下述基团取代C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷硫基、C1-C4烷基亚磺酰基、C1-C4烷基磺酰基、C1-C4烷基-S(O)2O、C1-C4卤代烷硫基、C1-C4卤代烷基亚磺酰基、C1-C4卤代烷基磺酰基、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；或者R10为基团Ar1-硫基，Ar2-亚磺酰基，Ar3-磺酰基，-OCO-Ar4或NH-Ar5，其中Ar1、Ar2、Ar3、Ar4和Ar5彼此独立地为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，且对于每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中的苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮上的取代基不能为卤素；R14、R15、R16、R17和R18彼此独立地为氢或C1-C6烷基；n8，n9，n10，n11，n12，n13和n14彼此独立地为0，1或2；R13为氢，C1-C4烷基，C1-C4烷硫基-C1-C4羰基，C1-C4烷基亚磺酰基-C1-C4羰基，C1-C4烷基磺酰基-C1-C4羰基，C1-C4烷氧基羰基，C1-C4烷基羰基，苯基羰基，或者为其本身还可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n15、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n16、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；以及n15和n16彼此独立地为0，1或2。
取代基定义中的烷基基团可以是直链的或支链的，并且例如为甲基、乙基、正丙基、异丙基、正丁基、仲丁基、异丁基、叔丁基、戊基、己基、庚基、辛基、壬基、癸基、十一烷基和十二烷基以及它们的支链异构体。烷氧基、链烯基和炔基基团则由上述烷基基团衍生得到。链烯基和炔基基团可以是单-或多不饱和的。
亚烷基基团例如-(CH2)m-、-(CH2)m1-或-(CH2)o-可以被一个或多个甲基基团取代，优选这些亚烷基基团在每种情况下是未取代的。这同样适用于-C(O)O(CH2)n20-和-S(O)n21(CH2)n22-基团，并且也适用于所有含有C3-C6-环烷基-、C3-C5氧杂环烷基-、C3-C5硫杂环烷基-、C3-C4二氧杂环烷基-、C3-C4二硫杂环烷基-、C3-C4氧硫杂环烷基的基团。
卤素通常指氟、氯、溴或碘。类似地，这也适用于处于其它组合含义如卤代烷基或卤代苯基中的卤素。
具有1-6个碳原子链长的卤代烷基例如为氟甲基、二氟甲基、三氟甲基、氯甲基、二氯甲基、三氯甲基、2，2，2-三氟乙基、1-氟乙基、2-氟乙基、2-氯乙基、2-氟丙-2-基、五氟乙基、1，1-二氟-2，2，2-三氯乙基、2，2，3，3-四氟乙基和2，2，2-三氯乙基、五氟乙基、七氟正丙基、全氟正己基；R2、R3、尤其是R5定义中的卤代烷基优选为三氯甲基、氟甲基、二氯氟甲基、二氟氯甲基、二氟甲基、三氟甲基、五氟乙基或七氟正丙基。
合适的卤代烷基是指单卤代-或多卤代的链烯基，其中的卤素指氟、氯、溴和碘，尤其是氟和氯，所述基团例如1-氯乙烯基、2-氯乙烯基、2，2-二氟乙烯基、2，2-二氟丙-1-烯-2-基、2，2-二氯乙烯基、3-氟丙-1-烯基、氯丙-1-烯-1-基、3-溴丙-1-烯-1-基、2，3，3-三氟丙-2-烯-1-基、2，3，3-三氯丙-2-烯-1-基和4，4，4-三氟丁-2-烯-1-基。在单卤代、二卤代或三卤代的C2-C6链烯基中，优选链长为2-5个碳原子的链烯基。
合适的卤代炔基例如为单卤代-或多卤代的炔基，其中的卤素指溴，碘且尤其是氟和氯，例如3-氟丙炔基、3-氯丙炔基、3-溴丙炔基、3，3，3-三氟丙炔基和4，4，4-三氟丁-2-炔-1-基。在单卤代或多卤代的炔基基团中，优选链长为2-5个碳原子的炔基。
单卤代或多卤代的C3-C6环烷基例如为2，2-二氯环丙基、2，2-二溴环丙基、2，2，3，3-四氟环丁基或2，2-二氟-3，3-二氯环丁基基团。
烷氧基基团优选具有1-6个碳原子的链长。烷氧基例如是指甲氧基、乙氧基、丙氧基、异丙氧基、正丁氧基、异丁氧基、仲丁氧基和叔丁氧基以及戊氧基和己氧基异构体；优选甲氧基和乙氧基。烷基羰基优选为乙酰基或丙酰基。烷氧基羰基例如为甲氧基羰基、乙氧基羰基、丙氧基羰基、异丙氧基羰基、正丁氧基羰基、异丁氧基羰基、仲丁氧基羰基或叔丁氧基羰基；优选甲氧基羰基、乙氧基羰基或叔丁氧基羰基。卤代烷氧基优选具有1-6个碳原子的链长。
卤代烷氧基例如为氟甲氧基、二氟甲氧基、三氟甲氧基、2，2，2-三氟乙氧基、1，1，2，2-四氟乙氧基、1-氟乙氧基、2-氟乙氧基、2-氯乙氧基、2，2-二氟乙氧基和2，2，2-三氯乙氧基；优选氟甲氧基、二氟甲氧基、2-氯乙氧基和三氟甲氧基。
烷硫基优选具有1-8个碳原子的链长。烷硫基例如为甲氧基、乙硫基、丙硫基、异丙硫基、正丁硫基、异丁硫基、仲丁硫基或叔丁硫基，优选甲硫基和乙硫基。烷基亚磺酰基例如为甲基亚磺酰基、乙基亚磺酰基、丙基亚磺酰基、异丙基亚磺酰基、正丁基亚磺酰基、异丁基亚磺酰基、仲丁基亚磺酰基、叔丁基亚磺酰基；优选甲亚磺酰基和乙亚磺酰基。
烷基磺酰基例如为甲磺酰基、乙磺酰基、丙磺酰基、异丙磺酰基、正丁基磺酰基、异丁基磺酰基、仲丁基磺酰基或叔丁基磺酰基；优选甲磺酰基和乙磺酰基。
烷基氨基例如为甲基氨基、乙基氨基、正丙基氨基、异丙基氨基或丁基氨基异构体。二烷基氨基例如为二甲氨基、甲基乙基氨基、二乙基氨基、正丙基甲基氨基、二丁基氨基和二-异丙基氨基。优选的烷基氨基具有1-4个碳原子链长。烷氧基烷基优选具有1-6个碳原子。烷氧基烷基例如为甲氧基甲基、甲氧基乙基、乙氧基甲基、乙氧基乙基、正丙氧基甲基、正丙氧基乙基、异丙氧基甲基或异丙氧基乙基。烷硫基烷基优选具有1-6个碳原子。烷硫基烷基例如为甲硫基甲基、甲硫基乙基、乙硫基甲基、乙硫基乙基、正丙硫基甲基、正丙硫基乙基、异丙硫基甲基、异丙硫基乙基、丁硫基甲基、丁硫基乙基或丁硫基丁基。
苯基本身以及作为诸如苯氧基、苄基、苄氧基、苯甲酰基、苯硫基、苯基烷基、苯氧基烷基或甲苯磺酰基之类取代基的一部分可以是单取代或多取代形式。在这种情况下，取代基位于邻位、间位或对位的任何位置上。
二烯基(allenyl)例如为CH2＝C＝CH2、CH2＝CH-CH2-CH＝CH2、CH2＝CH-CH2-CH2-CH＝CH2或CH2＝CH-CH2-CH＝CH-CH3。
本发明还涉及盐M+，它们可以由式I化合物，特别是其中R10为O-M+的那些式I化合物与(并且优选)胺、碱金属碱、碱土金属碱或季铵碱形成。在作为成盐物的碱金属碱和碱土金属碱中，必须强调下列碱锂、钠、钾、镁或钙的氢氧化物，特别是钠或钾的氢氧化物。适于形成铵盐的胺实例包括氨以及伯-、仲-和叔-C1-C18烷基胺、C1-C4羟烷基胺和C2-C4-烷氧基烷基胺，例如甲胺、乙胺、正丙胺、异丙胺、丁胺的四种异构体、正戊胺、异戊胺、己胺、庚胺、辛胺、壬胺、癸胺、十五碳烷胺、十六碳烷胺、十七碳烷胺、十八碳烷胺、甲乙胺、甲基异丙基胺、甲基己基胺、甲基壬基胺、甲基十五烷基胺、甲基十八烷基胺、乙基丁基胺、乙基庚基胺、乙基辛基胺、己基庚基胺、己基辛基胺、二甲基胺、二乙基胺、二正丙基胺、二异丙基胺、二正丁基胺、二正戊基胺、二异戊基胺、二己基胺、二庚基胺、二辛基胺、乙醇胺、正丙醇胺、异丙醇胺、N，N-二乙醇胺、N-乙基丙醇胺、N-丁基乙醇胺、烯丙胺、正丁烯基-2-胺、正戊烯基-2-胺、2，3-二甲基丁烯基-2-胺、二丁烯基-2-胺、正己烯基-2-胺、丙二胺、三甲基胺、三乙基胺、三正丙基胺、三异丙基胺、三正丁基胺、三异丁基胺、三仲丁基胺、三正戊基胺、甲氧基乙胺和乙氧基乙胺；杂环胺，例如吡啶、喹啉、异喹啉、吗啉、哌啶、吡咯烷、二氢吲哚、喹宁环和氮杂；伯芳胺，例如苯胺、甲氧基苯胺、乙氧基苯胺、邻-、间-和对-二甲基苯胺、苯二胺、萘胺和邻-、间-和对-氯苯胺；但是特别优选三乙胺、异丙胺和二异丙基胺。适于成盐的季铵碱实例例如为[N(RaRbRcRd)]+OH-，其中Ra，Rb，Rc和Rd彼此独立地为C1-C4烷基。具有其它阴离子的其它适宜四烷基铵碱例如通过阴离子交换反应得到。M+优选代表铵盐(特别是NH4+)或碱金属(特别是钾或钠)。
式I化合物可以以各种互变异构形式存在，例如当R10为羟基时以优选的式I′和I形式存在 式I化合物中，优选这些化合物及其农药上可耐受的盐M+以及式I化合物的所有立体异构体和互变异构体，其中p为0；R5为C1-C6卤代烷基；R2为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，苄基-S(O)n1-，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6-二烷基氨基磺酰基，苯基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，其中的苯基基团本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者为OS(O)n2-R21，N(R23)-S(O)n3-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基或C1-C4烷氧基-C1-C4烷氧基；R3为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6二烷基氨基磺酰基，苯基，苯硫基，苯基亚磺酰基，苯磺酰基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者为-N(R23)-S(O)n-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基或C1-C4烷基-S(O)n-C1-C4烷基；R4为氢，C1-C6烷基，C1-C4烷氧基，C1-C4卤代烷氧基，C1-C4烷基羰氧基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，C1-C4卤代烷基，甲酰基，氰基，卤素，苯基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代；或者R4为可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或R3-稠合二环环系，其中所述环系经由C1-C4亚烷基与吡啶环键连，且所述环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C1-C4烷氧基-C1-C2烷硫基，C1-C4烷基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷硫基，氰基-C1-C4烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，C2-C4二烷基氨基磺酰基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取，而且杂环中氮原子上的取代基不能为卤素；R21和R22彼此独立地为C1-C4烷基或C1-C4卤代烷基；R23、R24和R25彼此独立地为氢或C1-C4烷基；n，n1，n2，n3和n4彼此独立地为0，1或2；Q为Q1 其中R6、R7、R8和R9彼此独立地为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6炔基，C1-C6烷氧基羰基，C1-C6烷基-S(O)n17，C1-C6烷基-NHS(O)2，C1-C6烷基氨基，二-(C1-C6烷基)氨基，羟基，C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，羟基-C1-C6烷基，C1-C4烷基磺酰氧基-C1-C6烷基，甲苯磺酰氧基-C1-C6烷基，卤素，氰基，硝基，苯基或被下列基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n18、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n5、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n19N(C1-C4烷基)、卤素、硝基、COOH或氰基；或者相邻的R6与R7或R8与R9一起表示-(CH2)m-；n5，n17，n18和n19彼此独立地为0，1或2；m为2，3，4，5，或6；W为氧，S(O)n6，-CR11R12-，-C(O)-或-NR13-；n60，1或2；R11为氢，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基，C1-C4烷基羰氧基-C1-C4烷基，C1-C4烷基磺酰氧基-C1-C4烷基，甲苯磺酰氧基-C1-C4烷基，二-(C1-C3烷氧基烷基)甲基，二-(C1-C3烷硫基烷基)甲基，(C1-C3烷氧基烷基)-(C1-C3烷硫基烷基)甲基，C3-C5氧杂环烷基，C3-C5硫杂环烷基，C3-C4二氧杂环烷基，C3-C4二硫杂环烷基，C3-C4氧硫杂环烷基，甲酰基，C1-C4烷氧基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n21、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n7、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n20N(C1-C4烷基)、卤素、硝基、COOH或氰基；n7，n20和n21彼此独立地为0，1或2；或者R12与R9一起代表基团-(CH2)o-；o为1，2，3，4或5；R12为氢，C1-C4烷基或C1-C4卤代烷基；或者R12与R11一起代表基团-(CH2)m1；m1为2，3，4，5，或6；R10为羟基，O-M+，卤素，C1-C12烷氧基，C1-C12烷基羰氧基，C2-C4链烯基羰氧基，C3-C6环烷基羰氧基，C1-C12烷氧基羰氧基，C1-C12烷基羰氧基，R23R24N-C(O)O，C1-C12烷基S(O)n8-，C1-C4卤代烷基-S(O)n9-，C2-C12-链烯基S(O)n10-，C2-C12卤代链烯基S(O)n11-，C2-C12炔基S(O)n12-；苄氧基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，其中的苯基基团部分本身又可被下述基团取代C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n13、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n14、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基，或者为C1-C4烷基-S(O)2O，苯基-S(O)2O，(C1-C4烷氧基)2P(O)O，C1-C4烷基(C1-C4烷氧基)P(O)O，或H(C1-C4烷氧基)P(O)O；n8，n9，n10，n11，n12，n13和n14彼此独立地为0，1或2；R13为氢，C1-C4烷基，C1-C4烷氧基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n15、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n16、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；n15和n16彼此独立地为0，1或2。
在优选的一组式I化合物中，R10为卤素，氰硫基，C1-C12烷硫基，C1-C12烷基亚磺酰基，C1-C12烷基磺酰基，C1-C12卤代烷硫基，C1-C12卤代烷基亚磺酰基，C1-C12卤代烷基磺酰基，C1-C12链烯硫基，C2-C12链烯基亚磺酰基，C2-C12链烯基磺酰基，C2-C12卤代链烯硫基，C2-C12卤代链烯基亚磺酰基，C2-C12卤代链烯基磺酰基，C2-C12炔硫基，C2-C12炔基亚磺酰基，C2-C12炔基磺酰基，C1-C4烷氧基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷基亚磺酰基，C1-C4烷氧基羰基-C1-C2烷基磺酰基，C1-C8烷基-S(O)2NH，C1-C8卤代烷基-S(O)2NH，C1-C8烷基-S(O)2O，C1-C18烷基羰氧基，C2-C18链烯基羰氧基，C3-C6环烷基羰氧基，C1-C12烷氧基羰氧基，C1-C12烷硫基羰氧基，R16R17NC(O)O-，R16R17NC(S)O-，苄硫基，苄基亚磺酰基，苄基磺酰基，苯硫基，苯基亚磺酰基，苯基磺酰基，苯磺酰氧基或苯甲酰氧基，其中各苯基基团部分本身又可如权利要求1所述被取代；或者为基团Ar1-硫基，Ar1-亚磺酰基，Ar1-磺酰基，其中的Ar1为可以是芳香性或部分饱和的并且可以含有1-2个选自氮、氧和硫的杂原子的五-或六元单环环系，并且该环系本身又可如 1所述被取代；或者为噻吩基羰氧基或呋喃基羰氧基，这两个基团本身又可以被甲基或卤素取代，或者为其本身又可如权利要求1所述被取代的吡啶基羰氧基。
而且，在优选的式I化合物中，R10还为羟基或O-M+。
必须强调的其它式I化合物为这些，其中W为氧，-CR11R12-或-C(O)-，特别是当W为-CR11R12-的情形下，a)R6为氢，甲基，乙基，氰基，甲氧基羰基，乙氧基羰基，甲硫基，甲亚磺酰基，甲磺酰基或甲氧基；并且R7、R8、R9、R11和R12彼此独立地为氢，C1-C4烷基，C1-C3卤代烷基，C2-C3链烯基或C2-C3炔基，或b)相邻的R6与R7和/或R8与R9一起表示-(CH2)m-，-C(O)O(CH2)2-或-S(O)n21(CH2)3-；或c)R6为氢，甲基，乙基，甲氧基羰基，乙氧基羰基，甲硫基，甲亚磺酰基，甲磺酰基或甲氧基，并且R12与R9一起表示-(CH2)o-的化合物。
此外，优选的数组式I化合物为这些化合物，其中W为氧且R6、R7、R8和R9彼此独立地为氢或C1-C3烷基；或者W为-C(O)-且R6、R7、R8和R9彼此独立地为C1-C3烷基；或者R2为氢且R3为甲基；或者R2为甲基，乙基，正丙基，异丙基，乙烯基，甲氧基甲基，甲氧基羰氧基甲基，乙氧基羰氧基甲基，乙酰氧基甲基，丙酰氧基甲基，氯甲基，溴甲基，氟甲基，二氟甲基，三氟甲基或氰基甲基。
必须强调的其它式I化合物为这些化合物，其中R4为氢或甲基，或者R5为三氟甲基，二氟氯甲基，五氟乙基，七氟丙基或二氟甲基。
在另一组优选的式I化合物中，R3为氢，R2为C1-C4烷基，C1-C3卤代烷基，环丙基，C2-C3链烯基，C2-C3卤代链烯基，C2-C3炔基，丙二烯基(allenyl)，C1-C2烷氧基-C1-C2烷基，C1-C2烷硫基-C1-C2烷基，氰基-C1-C2烷基，C1-C2烷氧基羰基-C1-C2烷基，C1-C4烷基羰氧基-C1-C2烷基，C1-C3烷氧基，C1-C3卤代烷氧基，烯丙氧基，炔丙氧基，C1-C3烷硫基，C1-C3烷基亚磺酰基或氰基。
其中Q为基团Q1的式I化物可以应用本领域公知的方法(例如EP-A-0353187和EP-A-0316491中所述的方法)制备，例如通过a)在碱存在下，使式III化合物 其中R2、R3、R4和R5具有式I给出的含义，且X为离去基团，例如卤素或氰基，与式II化合物在惰性有机溶剂中反应
其中R6、R7、R8、R9和W具有式I给出的含义，生成式IV化合物 随后异构化后者，例如在碱和催化量的二甲氨基吡啶(DMAP)或氰化物源存在下进行；或者b)在碱和偶联剂存在下，使式XVI化合物 其中R2、R3、R4和R5具有式I给出的含义与式II化合物在惰性有机溶剂中反应 其中R6、R7、R8、R9和W具有式I给出的含义，生成式IV化合物 随后如路线a)所述异构体后者。
下面的反应流程I详细说明了式I化合物的制备。反应流程1路线a) 路线b) 基团Q1中R10为羟基的式I化合物优选按照该反应流程进行制备。按照反应流程1，路线a)制备其中Q为基团Q1且R10为羟基的式I化合物用的起始物质为式III羧酸衍生物，其中X为离去基团例如卤素(如碘、溴、尤其是氯)、N-氧化邻苯二甲酰亚胺或N，O-二甲基羟基氨基或活化酯部分，例如 (由二环己基碳二亚胺(DCC)与相应的羧酸形成)或 (由N-乙基-N′-(3-二甲氨基丙基)碳二亚胺(EDC)与相应的羧酸形成)。在碱例如烷基胺(优选三乙胺)或芳香胺(例如吡啶或4-二甲氨基吡啶(DMAP))存在下，这些式III化合物与式II二酮衍生物在惰性有机溶剂例如卤代烃(如二氯甲烷)、腈(如乙腈)、或芳烃(如甲苯)中反应，产生式IV的异构烯醇醚。该酯化反应在0℃-110℃下成功进行。
式IV的酯衍生物异构成式I二酮衍生物(其中R10为OH)的反应可以按照例如EP-A-0353187或EP-A-0316491的类似方法在碱和催化量DMAP或催化量的氰化物源(例如丙酮合氰化氢或氰化钾)存在下进行，其中的碱例如为烷基胺(如三乙胺)、碳酸盐(如碳酸钾)。这两步反应可以就地进行，无需分离中间体IV，特别是在使用式III氰化物(X＝氰基)或者在有催化量丙酮合氰化氢或氰化钾存在的情况下更是如此。
按照反应流程1，路线b)，所需的式I二酮化合物(其中R10为羟基)例如可以类似Chem.Lett.1975，1045所述制得，即在碱例如烷基胺(如三乙胺)和偶联剂(例如碘化2-氯-1-甲基吡啶鎓)存在下，在惰性溶剂例如卤代烃(如二氯甲烷)、腈(如乙腈)或芳烃(如甲苯)中用式II二酮衍生物酯化式XVI羧酸。依据所用溶剂，该酯化反应在0℃-110℃的温度下成功进行，并且如路线a)所述首先生成式IV的异构酯，后者可如路线a)所述进行异构化，例如在碱和催化量的DMAP，或氰化物源存在下，异构产生所需的式I二酮衍生物(R10＝羟基)。
反应流程I(路线a)中的式III活化羧酸衍生物(其中X为离去基团，例如卤素(如溴、碘或者特别是氯))可用已知的标准方法制备，例如下列文献中所述的方法C.Ferri“Reaktionen der organischenSynthese”[“有机合成反应”]，Georg Thieme Verlag，Stuttgart，1978，p.460之后。该反应由下述反应流程2说明。反应流程2 按照反应流程2，其中X具有上述含义的式III化合物的制备例如使用卤化剂，例如亚硫酰卤(如亚硫酰氯或亚硫酰溴)；卤化磷或磷酰卤(如五氯化磷或磷酰氯，或五溴化磷或三溴氧化磷)；或草酰卤(如草酰氯)，或使用能形成活化酯的式XVII的试剂，例如N，N′-二环己基碳二亚胺(DCC)或N-乙基-N′-(3-二甲氨基丙基)碳二亚胺(EDC)。作为卤化剂的式XVII化合物中的X含义实例为离去基团，例如卤素(如氟、溴或碘，特别是氯)，并且W1例如为PCl2，SOCl，SOBr，或ClCOCO。
反应优选在催化量的N，N-二甲基甲酰胺存在下在惰性有机溶剂中于-20℃至反应混合物的回流温度下，优选在40-150℃进行，其中所述的惰性有机溶剂例如为脂族、卤代脂族、芳族或卤代芳族烃，如正己烷、苯、甲苯、二甲苯、二氯甲烷、1，2-二氯乙烷或氯苯。这类反应通常是已知的，并且各种不同的离去基团X在文献中均有记载。
其中R10不为羟基或卤素的式I化合物可以利用文献中公知的转化方法制备，例如以其中R10为羟基的化合物为原料，在适当碱存在下使用合适的酰氯通过酰化或甲氨酰化方法制备，或者通过对其中R10为卤素的式I氯化物进行亲核取代制备，而其中的式I氯化物也可以通过按照已知方法与氯化剂如光气、亚硫酰氯或草酰氯反应制得。在这种情况下，所用化合物的实例为适当取代的胺，或者直接为羟胺，或者为烷基磺酰胺、硫醇、硫酚类、酚类、Ar5-NH2或Ar1-SH，其中需要有碱如5-乙基-2-甲基吡啶、二异丙基乙胺、三乙胺、碳酸氢钠、乙酸钠或碳酸钾存在。
其中R10包含硫基的式I化合物可以按照与已知标准方法类似的方式，例如使用过酸(如间-氯过苯甲酸(m-CPBA)或过乙酸)氧化生成相应的式I砜和亚砜。硫原子的氧化程度(SO-或SO2-)可以根据氧化剂的用量加以控制。
所产生的其中R10不为羟基的式I衍生物同样也能够以各种异构形式存在，如果需要的话，可以分离它们成纯净形式。因此本发明还涉及所有这些立体异构体。这些异构体的实例为下面的式I*，I**和I***，其中Q为基团Q1(同样可参见上文第11页的说明与结构图)。 考虑到吡啶基或Q部分的化学性质，式I范围内的所有其它化合物均可以很容易地制得。
式I终产物的分离可以按照常规方式通过浓缩或蒸发溶剂，进而在它们难以溶解的溶剂如醚、芳烃或氯化烃中重结晶或研制固体残渣完成，或者通过蒸馏或利用柱色谱和适宜的洗脱剂完成。
另外，专业技术人员也都熟悉为避免副反应而适当进行的某些反应的次序。当没有进行分离纯净异构体的定向合成时，所得产物可以是两种或多种异构体的混合物。这些异构体可以用本领域公知的方法拆分。
其中n为1的式I化合物，亦即相应的式IN-氧化物，可以通过其中n为0的式I化合物与适当氧化剂(例如H2O2-脲加合物)在酸酐(如三氟乙酸酐)存在下反应合成。
其中R位于吡啶氮的邻位，并且代表1-氯-C1-C2烷基，1-羟基-C1-C2烷基，1-(C1-C6烷基羰氧基)-C1-C2烷基，1-苯甲酰氧基-C1-C2烷基，1-(C1-C4烷氧基羰氧基)-C1-C2烷基，1-(C1-C4烷硫基)-C1-C2烷基，1-(C1-C4烷基亚磺酰基)-C1-C2烷基，1-(C1-C4烷基磺酰基)-C1-C2烷基，1-氰硫基-C1-C2烷基，1-氰基-C1-C2烷基的式I化合物，还可以通过例如在已知反应条件下加热式I的N-氧化物制备，例如在甲苯磺酰氯存在下进行(参见例如Parham，W.E.；Sloan，K.B.；Reddy，K.R.；Olson，P.E.；JOrg Chem(有机化学杂志)1973，38，927)，或者在酸酐存在下进行(参见例如Konno，K.；Hashimoto，K.；Shirahama，H.；Matsumoto，T.；Heterocycles 1986，24，2169)，并且如果合适的话，随后进一步反应所得产物。这些反应次序可以用下述实例加以说明。
其中R位于吡啶氮的邻位，且尤其是代表1-溴-C1-C2烷基，1-氯-C1-C2烷基，1-氟-C1-C2烷基，1，1-二溴甲基，1，1-二氯甲基，甲酰基，1-(C1-C4烷硫基)-C1-C2烷基，1-(C1-C4烷基亚磺酰基)-C1-C2烷基，1-(C1-C4烷基磺酰基)-C1-C2烷基，1-氰硫基-C1-C2烷基或1-氰基-C1-C2烷基的式I化合物，也可以通过例如在已知的卤化反应条件下氧化其中R10尤其是氯、C1-C4烷氧基羰氧基或苯甲酰基羰氧基的式I化合物制备，例如在光和游离基引发剂(例如过氧化苯甲酰)存在下用N-溴代琥珀酰亚胺或N-氯代琥珀酰亚胺进行，生成1-溴或1-氯、1，1-二溴或1，1-二氯化合物，随后再次官能化后者，得到相应衍生物。这些反应次序也可以借助下列实例加以说明。 式I化合物还可以如下合成在-100至-20℃(优选-70至-50℃)的温度下，在惰性溶剂(例如四氢呋喃)中使其中p为0而R2为C1-C6烷基的式I化合物与适当碱例如二异丙基氨化锂或正丁基锂反应，生成相应的双阴离子物。专业技术人员懂得如何通过亲电取代，例如使用氯甲酸酯来转化这些负碳离子物。这一反应次序可参照下述实例说明 考虑到吡啶基或Q部分的化学性质，式I范围内的其它化合物可用适当的亲电子试剂制备。
式IIIa化合物是新的，并且具体讲这些化合物用于式I化合物的制备，因而它们构成了本发明的进一步主题 其中R501为C1-C6卤代烷基；R301为氢；R401为氢或C1-C6烷基；并且R201为C1-C6烷基，C1-C6卤代烷基-C1-C4烷基，C2-C6链烯基，C2-C6卤代链烯基，或C1-C2烷氧基羰基-或苯基-取代的乙烯基，C2-C6炔基或C2-C6卤代炔基；或者为三甲基甲硅烷基-、羟基-、C1-C2烷氧基-、C1-C2烷氧基羰基-或苯基-取代的乙炔基，或C3-C6二烯基；或者为C3-C6环烷基，卤代C3-C6环烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4氰硫基，环氧乙烷基，C1-C4烷基氨基-C1-C4烷基，C1-C4二烷基氨基-C1-C4烷基，羟基-C1-C4烷基，C1-C12烷硫基羰基-C1-C4烷基或甲酰基-C1-C4烷基，或者R201为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2S-、-CH2SO-或-CH2SO2-基团与吡啶环键连，且每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；以及X为卤素或氰基。
式XVIa化合物是新的，并因此构成了本发明的另一主题 其中R201，R301，R401和R501具有上述含义，但条件是当R501为三氟甲基、同时R301和R401均为氢时，则R201不为C1-C6烷基。
式Q1(或式II)的化合物是已知的，并且可以按照例如下列文献所述的类似方法制备J.Org.Chem.(1977)，42，1163-9，英国专利申请GB2205316，DE3902818，GB8706557，DE4434987，WO9213821和Aust.J.Chem.(1976)，29(11)，2525-31，Chem.Commun.(1998)，(16)，1691-1692.
式XVI(或XVIa和XVIb)的化合物按照与已知方法(例如Heterocycles，46，129(1997)或Helvetica Chimica Acta71，596(1988)中所述的方法)类似的方法合成，并且其特征在于a)在碱例如芳香胺(如吡啶)存在下，用式VI化合物 其中R501为C1-C6卤代烷基，酰化式V化物 其中R301为氢；R401为氢，C1-C6烷基或苯基，其中苯基基团本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代；或者R401为可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C1-C4烷氧基-C1-C2烷硫基，C1-C4烷基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷硫基，氰基-C1-C4烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；以及R14为C1-C14烷基；生成式VII化合物 其中R301，R401，R501和R14具有上述含义，然后在有机溶剂，例如卤代烃(如二氯甲烷)、腈(如乙腈)中，利用氨将其中的烷氧基交换为氨基。所得式VIII化合物 随后与式IX化合物进行缩合反应 其中R201为C1-C6烷基，C1-C6卤代烷基-C1-C4烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4烷氧基羰氧基-C1-C4烷基，C1-C4氰硫基-C1-C4烷基，环氧乙烷基，C1-C4烷基氨基-C1-C4烷基，二(C1-C4)烷基氨基-C1-C4烷基或甲酰基-C1-C4烷基；或者R201为基团Ar6-C1-C4烷基，其中的Ar6为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，其中每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素，且R14具有上述含义，其后水解所生成的式Xa化合物 得到式XVIa化合物 其中R201，R301，R401和R501具有上述含义；或者b)使其中R14具有上述含义的式XI化合物 与式XII化合物进行缩合反应 并且氯化(例如使用POCl3)所生成的式XIII化合物 其中R3，R4和R5具有上述含义，且R14为C1-C4烷基，得到式XIV化合物 其中R3，R4，R5和R14具有上述含义，随后在碱存在下将这一化合物与式XV亲核试剂反应Z-R15(XV)其中Z为SH，OH或氨基，且R15为C1-C6烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷基磺酰基，C1-C6卤代烷基，苯基或苄基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者为C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基，C1-C4烷基亚磺酰基-C1-C4烷基，C1-C4烷基磺酰基-C1-C4烷基，C1-C4烷基磺酰基或二-(C1-C4烷基)氨基磺酰基，或者R15为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，其中每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，(CH2)nR7，NR8R9，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素，得到式Xb化合物 其中R14，R15，R3，R4，R5和Z具有上述含义，随后水解所得化合物，生成式XVIb的化合物 其中R15，R3，R4，R5和Z具有上述含义。
其中Z-R15中的Z为氧且R15为C1-C6烷基，C3-C6链烯基，C3-C6炔基，C1-C6卤代烷基，C3-C6卤代链烯基，氰基-C1-C4烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基或C1-C4烷氧基羰基-C1-C4烷基的化合物也可以以XIII为起始原料通过用相应的烷基化剂L-R15XVa直接烷基化制备，其中的L为离去基团，如氯、溴、碘、甲磺酰氧基或甲苯磺酰氧基。
其中Z-R15为氟的式XVIb化合物的制备是在极性非质子传递溶剂例如乙腈、二甲基甲酰胺或环丁砜存在下由式XIV化合物与氟化钾以及，如果合适的话，催化量的18-冠-6反应完成。其中Z-R15为氢的式XVIc化合物则是通过在适当溶剂中还原式XIV中的氯基团制得，例如在适当金属催化剂存在下用氢还原或用甲酸铵还原。下面的反应流程3和4详细描述了式XVI或XVIa、XVIb和XVIc的化合物的制备。反应流程3 反应流程4
其中R2为溴甲基，氰基甲基，氰硫基甲基，C2-C6链烯基，C2-C6卤代链烯基，C1-C2烷氧基羰基-或苯基-取代的乙烯基，C2-C6炔基，C2-C6卤代炔基，三甲基甲硅烷基-、羟基-、C1-C2烷氧基-、C1-C2烷氧基羰基-或苯基-取代的乙炔基，C3-C6二烯基，C3-C6环烷基或单-或多-卤代C3-C6环烷基的式XVId化合物例如可以按照反应流程4a中所示的公知转化方法制备。反应流程4a
其中R501为CF2Cl的式XVIa中间体的制备如流程3所述，或者通过其中R501为三氯甲基的式Xa化合物与氢氟酸在加压容器中于0-220℃(优选60-200℃)的温度下反应完成。
其中R501为CHF2的式XVIa化合物可如流程3所述制备，或者按下所述制备在催化量偶氮-异丁腈存在下，在惰性溶剂如甲苯或苯中于25-120℃(优选80-120℃)下加热式Xa化合物(其中R301、R401、R14和R201具有上述含义，且R501为CF2Cl)与三丁基氢化锡或1，1，1，3，3，3-六甲基-2-(三甲基甲硅烷基)丙硅烷，随后水解生成的化合物，得到其中R501为CHF2的式XVIa化合物。
其中R201、R301、R401和R501具有上述含义的式XVIa化合物也可以如下制备通过亲核取代使其中R14、R301、R401和R501具有上述含义而R201为CH2Cl的式Xc化合物发生反应，例如使用碱金属碘化物在惰性溶剂中进行所述反应，生成相应的碘化物，或者使用气态氢溴酸在低级羧酸如冰乙酸中进行反应，得到相应的溴衍生物(例如按照US-3974166所述方法)或者使用碱金属氟化物在偶极溶剂如环丁砜中进行反应，得到相应的氟衍生物，或者，为了制备烷氧基基团Xd，在碱如氢化钠或碱土金属氧化物或碱土金属碳酸盐存在下使卤素衍生物Xc与醇或酚反应，或者直接与碱金属醇盐在惰性溶剂如二甲基甲酰胺中反应，或者在过量与要引入基团相对应的醇ROH存在下于-5至160℃下进行，或者，为了制备相应的芳香或脂族硫醚Xe，类似于上文所述，在-10-150℃下，在惰性溶剂中使卤化物Xc与脂族或芳族硫醇在碱如氢化钠存在下反应，或者与硫醇的碱金属盐反应，或者，为了制备相应的亚磺酰基或磺酰基衍生物Xe，在惰性溶剂如二氯甲烷中与氧化剂如间-氯过苯甲酸或高碘酸钠或过硼酸钠进行反应，其中温度的控制是本领域已知的，它取决于氧化的程度(例如，对于n＝1，温度为-30℃-+50℃；而对于n＝2，则温度为-20℃-+100℃)，从而得到Xf，或者，为了制备式Xg的氰基亚甲基衍生物，使式Xc的卤化物与碱金属氰化物或四烷基氰化铵或氰化铜在惰性溶剂如二氯甲烷、四氢呋喃或二甲基甲酰胺中于0℃-220℃下反应。
式XVIa化合物(R501＝CF2Cl)以及式Xc、Xd、Xe、Xf和Xg中间体的制备用下述反应流程5、6和7详细说明。反应流程5 反应流程6 反应流程7
为了制备按照R201(Z-R15)-R501的定义而官能化的式X和XVI的所有其它化合物，多种已知的标准方法都是合适的，例如烷基化、卤化、酰化、酰胺化、肟化、氧化及还原，但适宜制备方法的选择取决于中间体中取代基的性质(反应性)。
形成式I化合物的反应宜在非质子传递惰性有机溶剂中进行。这类溶剂为烃例如苯、甲苯、二甲苯或环己烷，氯代烃如二氯甲烷、三氯甲烷、四氯化碳或氯代苯，醚如乙醚、乙二醇二甲醚、二甘醇二甲醚、四氢呋喃或二噁烷，腈如乙腈或丙腈，酰胺如N，N-二甲基甲酰胺、N，N-二乙基甲酰胺或N-甲基吡咯烷酮。反应温度优选为-20℃至+120℃。在某些情况下，反应是轻微放热的，通常它们可以在室温下进行。为了缩短反应时间或者为了起动反应，可以将反应混合物迅速加热到沸点。通过加入几滴碱作为反应催化剂同样可以缩短反应时间。合适的碱特别是叔胺例如三甲胺、三乙胺、喹宁环、1，4-二氮杂二环[2.2.2]辛烷、1，5-二氮杂二环[4.3.0]壬-5-烯或1，5-二氮杂二环[5.4.0]十一碳-7-烯。但是也可以使用无机碱例如氢化物如氢化钠或氢化钙、氢氧化物如氢氧化钠或氢氧化钾、碳酸盐如碳酸钠和碳酸钾、或碳酸氢盐如碳酸氢钾和碳酸氢钠作为碱。按照常规方式，通过浓缩和/或蒸发溶剂，可以分离出式I的化合物，并且可以通过重结晶或者在不易溶解的溶剂例如醚、芳香烃或氯代烃中研制固体残留物或而加以纯化。
就本发明的式I化合物或含有它们的组合物来说，使用它们的适宜方法包括所有农业上常规施用方法，例如芽前施用、芽后施用和种子处理以及各种方法和技术例如活性组分的受控释放。为此，使活性组份的溶液吸附到矿物颗粒载体或聚合物颗粒(脲/醛树脂)上，然后干燥。如果合适的话，可以另外包衣(包衣颗粒)，使得活性组份能在特定的时间内以受控方式释出。
式I化合物可以以原有形式即合成得到形式用作除草剂。但优选将它们按常规方式与加工配制领域惯常使用的赋型剂一起配制成例如乳油、可直接喷洒或可稀释的溶液、稀乳液、可湿性粉剂、可溶性粉剂、撒粉剂、颗粒剂或微囊剂形式。例如在WO97/34485的第9-13页描述了这些制剂。根据预定目的和周围环境选择施用方法(例如喷洒、雾化、撒粉、湿润、散布或倾倒)以及组合物的类型。
制剂即包含式I活性组份或包含至少一种式I活性组分以及一种或多种固体或液体制剂用助剂的组合物、制品或产物可以按照常规方式制备，例如通过把活性组份与制剂用助剂如溶剂或固体载体致密混合和/或研磨。另外，在制备制剂时也可以使用表面活性化合物(表面活性剂)。例如在WO97/34485的第6页中给出的溶剂和固体载体实例。
根据所配制的式I活性组分的性质，合适的表面活性化合物是具有良好的乳化性、分散性和湿润性的非离子型、阳离子型和/或阴离子型表面活性剂和表面活性剂的混合物。
例如在WO97/34485的第7和8页中列出了合适的阴离子型、非离子型和阳离子型表面活性剂实例。
此外，特别是在“McCutcheon洗涤剂和乳化剂年报”(McCutcheon’s Detergents and Emulsifiers Annual)MC PublishingCorp.，Ridgewood New Jersey，1981，Stache，H.，“Tensid-Taschenbuch”[“表面活性剂指南”]，Carl Hanser Verlag，Munich/Vienna，1981和M.和J.Ash，“表面活性剂大全”(Encyclopedia of Surfactants)，Vol.I-III，Chemical PublishingCo.，New York，1980-81中描述的制剂加工技术中常用的表面活性剂也适用于配制本发明的除草组合物。
除草组合物一般含有0.1-99％重量、尤其是0.1-95％重量的除草剂，1-99.9％重量、尤其是5-99.8％重量的固体或液体加工助剂和0-25％重量特别是0.1-25％重量的表面活性剂。虽然更优选市售产品形式的浓缩物组合物，但最终使用者往往要使用稀释制剂。组合物还可以包含其它添加剂，例如稳定剂如环氧化或非环氧化的植物油(环氧化的椰子油、油菜油或大豆油)、消泡剂如硅油、防腐剂、粘度调节剂、结合剂、增粘剂以及肥料或其它活性组份。
通常，式I活性成分按0.001-4kg/公顷，特别是0.005-2kg/公顷的施用量施于植物或其周围环境。达到所需效果的需要剂量可以通过试验确定。它取决于作用的类型、栽培植物和杂草的发育阶段以及施用(地点、时间和方法)，并且根据这些参数可以在很宽的范围内变化。
式I化合物具有优越的除草和抑制生长的性能，从而使得它们能够用于有用作物，特别是谷类、棉花、大豆、甜菜、甘蔗、栽培作物、油菜、玉米和稻，以及用于非选择性的杂草防除。“作物”应当理解为还包括利用常规繁殖方法或基因工程技术产生的能耐受除草剂的作物。要防除的杂草可以是单子叶或双子叶杂草，例如繁缕属、豆瓣菜属、剪股颍属、马唐属、燕麦属、狗尾草属、白芥属、黑麦草属、茄属、稗属、莞草属、雨久花属、慈姑属、雀麦属、看麦娘属、石茅高粱、筒轴茅属、莎草属、苘麻属、黄花稔属、苍耳属、苋属、藜属、番薯属、茼蒿属、猪殃殃属、堇菜属和婆婆纳属。
下列实施例用于更详细说明本发明，但本发明并不局限于此。制备实施例实施例H1制备3-羟基-4，4-二甲基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(化合物A2-B24)将6.68g(0.0305mol)2-甲基-6-三氟甲基烟酸甲酯(按照Heterocycles，46，129(1997)中所述制得)溶于250ml甲醇/水(3∶1混合物)，在22℃下分批加入1.92g(0.046mol)氢氧化锂水合物。22℃反应4小时后，将反应混合物倒入乙酸乙酯和2N盐酸内，水洗有机相三次，硫酸钠干燥并蒸发，进而用少量己烷研制残留物。过滤后得到5.69g(90％理论产率)2-甲基-6-三氟甲基烟酸，熔点147-149℃。
将所得2-甲基-6-三氟甲基烟酸(1.026g，0.005mol)溶于20ml草酰氯。加入三滴二甲基甲酰胺，回流混合物1小时。然后用旋转蒸发器浓缩混合物，并将残留物(2-甲基-6-三氟甲基烟酰氯)溶于100ml二氯甲烷。在0℃下加入1.6ml(0.0115mol)三乙胺和0.7g(0.005mol)4，4-二甲基环己烷-1，3-二酮。22℃下反应2小时后，利用真空旋转蒸发器除去溶剂，进而将残留物溶于55ml乙腈，加入0.15ml(0.0016mol)丙酮合氰化氢和0.79ml(0.0057mol)三乙胺使中间体发生重排反应。室温搅拌反应溶液4小时后进行蒸发。硅胶层析剩余的浆状物，以甲苯、乙醇、二噁烷、三乙胺以及水组成的混合物(100∶40∶20∶20∶5体积份)洗脱，得到浅黄色粘性油状物(Rf＝0.39，上述混合物作为流动相)，进而将其溶于二氯甲烷，依次用75ml 5％盐酸和75ml水洗涤。蒸发硫酸钠干燥过的有机溶液至干，得到1.05g(63％)纯净3-羟基-4，4-二甲基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮，白色结晶体，熔点75-77℃。1H NMR(d6-DMSO，δin ppm)1.342，s，6H2.088，t，J9Hz，2H2.685，s，3H2.982，t，J9Hz，2H8.030，d，J8.1Hz，1H8.094，d，(J，8.1Hz)，1H.实施例H2制备5-甲基-5-三氟甲基环己烷-1，3-二酮(化合物H-B1066)往40ml乙醇中投入0.64g钠，接着加入3.23ml乙酰乙酸甲酯和4.9g 4，4，4-三氟-3-甲基丁-2-烯酸异丙酯，并在沸腾状态下加热混合物18小时。在将混合物分配到稀盐酸与乙酸乙酯之内后，蒸发混合物。剩余的2-甲基-4，6-二氧代-2-三氟甲基环己烷羧酸甲酯粗品进而在9.1g氢氧化钠存在下于甲醇与水的混合液中沸腾水解。混合物随后用盐酸酸化，并用新鲜乙酸乙酯提取。经重结晶(乙酸乙酯)后得到纯净5-甲基-5-三氟甲基环己烷-1，3-二酮，熔点150-152℃。实施例H3制备2-羟基-1-甲氧基-5-甲基-4-氧代环己-2-烯羧酸甲酯(实施例H-B1069)向65ml二甲亚砜中加入30％35.8g甲醇钠溶液，接着在30-35℃、20分钟内用16.7g 3-甲基-3-丁烯-2-酮和32.4g甲氧基丙二酸二甲酯处理。35℃搅拌混合物1小时，然后用盐酸酸化，并用二氯甲烷重复提取。水洗有机相，然后干燥并浓缩。用热乙酸乙酯和己烷结晶得到2-羟基-1-甲氧基-5-甲基-4-氧代环己-2-烯羧酸甲酯纯品，熔点117-117.5℃。实施例H4制备2-羟基-1-甲氧基-5-甲基-3-(2-甲基-6-三氟甲基吡啶-3-羰基)-4-氧代环己-2-烯羧酸甲酯(化合物A2-B1069)向2.14g 2-羟基-1-甲氧基-5-甲基-4-氧代环己-2-烯羧酸甲酯和2.02g三乙胺在30ml乙腈中的混合物内加入2.23g新鲜2-甲基-6-三氟甲基烟酰氯。大约30分钟后，加入0.065g氰化钾，搅拌混合物18小时。在pH为2的情形下，将混合物随后分配到水与乙酸乙酯之间，硫酸镁干燥并蒸发。硅胶过滤(流动相乙酸乙酯/甲醇/三乙胺85∶10∶5)得粘性油状2-羟基-1-甲氧基-5-甲基-3-(2-甲基-6-三氟甲基吡啶-3-羰基)-4-氧代环己-2-烯羧酸甲酯纯品。实施例H5制备3-羟基-4-甲氧基-6-甲基-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(化合物A2-B1070)用0.586g氢氧化钾处理1.4g 2-羟基-1-甲氧基-5-甲基-3-(2-甲基-6-三氟甲基吡啶-3-羰基)-4-氧代环己-2-烯羧酸甲酯的二噁烷/水(5∶3)溶液，并搅拌所得混合物3小时。随后酸化混合物(pH3)，用新鲜乙酸乙酯提取。类似实施例H4所述，将粗产物通过色谱纯化。得到3-羟基-4-甲氧基-6-甲基-2-(2-甲基-6-三氟甲基-吡啶-3-羰基)环己-2-烯酮粘性油状物(根据1H-NMR，它为3种互变异构体的混合物)。实施例H65-氯-2，2，6，6-四甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮(化合物A2-B1105)和6-[氯-(2-甲基-6-三氟甲基吡啶-3-基)亚甲基]-2，2，4，4-四甲基环己烷-1，3，5-三酮向18.5g(50mmol)5-羟基-2，2，6，6-四甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮(化合物A2-B354)在50ml二氯甲烷中的溶液内加入7.0g(55mmol)草酰氯；接着加入5滴二甲基甲酰胺，缓慢加热混合物至沸点。大约30分钟后，在不再有气体逸出的情形下蒸发混合物，产物通过加正己烷结晶。所得主产物为纯净的5-氯-2，2，6，6-四甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮，m.p.119.5-120℃。进一步通过HPLC分离母液(使用5-10％乙酸乙酯/己烷)，得到异构体6-[氯-(2-甲基-6-三氟甲基吡啶-3-基)亚甲基]-2，2，4，4-四甲基环己烷-1，3，5-三酮，m.p.92.5-93℃。实施例H75-氯-2，2，6，6-四甲基-4-(2-甲基-1-氧-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮(化合物A1210-B1105)-10℃下，在20ml二氯乙烷中用0.94g(10mmol)过氧化氢/脲加合物和1.89g(9mmol)三氟乙酸酐处理1.94g(5mmol)5-氯-2，2，6，6-四甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮。搅拌下，温热反应混合物至室温，在这一温度下进一步保持4小时。然后将混合物分配到乙酸乙酯与pH为5的水之间，用氯化钠溶液洗涤并蒸发。通过硅胶过滤得到的残留物为纯净的5-氯-2，2，6，6-四甲基-4-(2-甲基-1-氧-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮，熔点145.5-146℃。实施例H84-(2-溴甲基-6-三氟甲基吡啶-3-羰基)-5-氯-2，2，6，6-四甲基环己-4-烯-1，3-二酮(化合物A1029-B1105)在催化量过氧化二苯甲酰存在下，在10ml四氯化碳中回流0.39g(1mmol)5-氯-2，2，6，6-四甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮与0.20g(1.1mmol)N-溴代琥珀酰亚胺。反应平息之后，滤除所产生的琥珀酰亚胺，将粗产物通过柱色谱纯化(流动相乙酸乙酯/己烷1∶4)。从而得到4-(2-溴甲基-6-三氟甲基吡啶-3-羰基)-5-氯-2，2，6，6-四甲基环己-4-烯-1，3-二酮纯品，熔点94.5-95℃。实施例H9乙酸2-(2-乙酰氧基甲基-6-三氟甲基吡啶-3-羰基)-4，4，6，6-四甲基-3，5-二氧代环己-1-烯基酯(化合物A1099-B1107)在3ml乙酐存在下，回流0.4g(1mmol)5-氯-2，2，6，6-四甲基-4-(2-甲基-1-氧-6-三氟甲基吡啶-3-羰基)环己-4-烯-1，3-二酮(实施例H7)25分钟。然后浓缩混合物，进而分配到乙酸乙酯与pH为6.5的碳酸氢钠溶液之间。将粗产物通过硅胶加以分离(流动相乙酸乙酯/己烷1∶4)，从而得到油状乙酸2-(2-乙酰氧基甲基-6-三氟甲基吡啶-3-羰基)-4，4，6，6-四甲基-3，5-二氧代环己-1-烯基酯纯品，1H-NMR(CDCl3)7.98d，CH，7.72d，CH，5.62s，CH2，2.22和2.202x OAc，1.58，s，2x CH3，1.44ppm，s，2x CH3.实施例H105-羟基-2-甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)-二环[4.1.0]庚-4-烯-3-酮(化合物A2-D109)和3-羟基-7-甲基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环庚-2.6-二烯酮(化合物A2-F5)室温下，在2∶1的二噁烷/水混合液中搅拌0.82g(2mmol)反式-5-羟基-2-甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)-3-氧代二环[4.1.0]庚-4-烯-2-羧酸乙酯(化合物A2-D111)与0.254g(4.5mmol)氢氧化钾至所有起始原料反应完全为止。然后加入乙酸乙酯，用4N HCl酸化混合物至pH3，在40℃下加热该两相混合物大约1小时。水相用氯化钠饱和，然后分离弃之。蒸发乙酸乙酯提取物至干，硅胶层析所得产物(流动相乙酸乙酯/己烷1∶2)。分离得到的第一个馏分为3-羟基-7-甲基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环庚-2，6-二烯酮，为纯净的互变异构体混合物，1H-NMR(CDCl3)17.72和17.08，2s，OH，7.6-7.45，2芳香H，6.68和6.62，2t，CH，2.84，m，2.63，m，2.52，m，4H，2.62和2.54，2s，CH3，2.03和1.77ppm，2s，CH3.随后用100％乙酸乙酯洗脱，得到第二个馏分，即5-羟基-2-甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)二环[4.1.0]庚-4-烯-3-酮的异构体和互变异构体混合物，1H-NMR(CDCl3)尤其为17.62和17.48，2s，OH，7.6-7.45，2芳香H，2.54，m，2.48，2s CH3，1.22和1.14，2d，CH3，1.00-0.05ppm，2H.实施例H115-羟基-2-甲亚磺酰基-2-甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)二环[4.1.0]庚-4-烯-3-酮(化合物A2-D114)在0.56g高碘酸钠存在下，50℃温热0.87g(2.3mmol)5-羟基-2-甲基-2-甲硫基(methylsulfanyl)-4-(2-甲基-6-三氟甲基吡啶-3-羰基)二环[4.1.0]庚-4-烯-3-酮(化合物A2-D113)在8ml甲醇中的溶液3小时。然后将混合物分配到乙酸乙酯与氯化钠溶液之间，浓缩，并将粗产物通过色谱纯化(流动相乙酸乙酯/甲醇19∶1)。得到纯净的5-羟基-2-甲亚磺酰基-2-甲基-4-(2-甲基-6-三氟甲基吡啶-3-羰基)二环[4.1.0]庚-4-烯-3-酮，为互变异构体与异构体混合物，熔点159.5-160℃.实施例H122-丙-2-炔基氧基-6-三氟甲基烟酸(化合物A1025)在催化量18-冠-6醚存在下，在40ml二甲基甲酰胺与80ml乙腈的混合液中加热47g(0.2mol)2-氧代-6-三氟甲基-1，2-二氢吡啶-3-羧酸、20ml(0.25mol)炔丙基溴和43g(0.31mol)碳酸钾到75℃。5小时后，将混合物分配到乙酸乙酯与氯化钠饱和溶液之间。粗产物通过硅胶柱过滤(使用15％乙酸乙酯/己烷)。所得油状形式的主要组分为纯净2-丙-2-炔基氧基-6-三氟甲基烟酸乙酯；1H-NMR(CDCl3)8.31，d，CH，7.38，d，CH，5.13，d，CH2，4.41，q，CH2，2.48，t，CCH，1.41 ppm，t，CH3.
将36.3g(0.13mol)该产物与11.5g(0.17mol)氢氧化钾在50ml水与50ml二噁烷中的溶液一同搅拌16小时。经酸化及乙酸乙酯提取之后，得到结晶2-丙-2-炔基氧基-6-三氟甲基烟酸；1H-NMR(CDCl3)10.0，b，OH，8.53，d，CH，7.44，d，CH，5.22，d，CH2，2.54ppm，t，CCH.实施例H132-甲硫基-6-三氟甲基烟酸(化合物A15)
35℃下，将9.4g(40mmol)2-氧代-6-三氟甲基-1，2-二氢吡啶-3-羧酸加到21.7g三溴化磷(80mmol)的1M二氯甲烷溶液内。然后蒸除溶剂，缓慢加热反应混合物至沸点(大约175℃)。18小时后，冷却化合物到0℃，加二氯甲烷稀释，并与pH1.8的冰水一同搅拌。然后用碳酸钠冷溶液以及15％氯化钠溶液洗涤有机相，硫酸镁干燥并浓缩。残留物为2-溴-6-三氟甲基烟酸乙酯油状物；1H-NMR(CDCl3)8.20，d，CH，7.72d，CH，4.46，q，CH2，1.42ppm，t，CH3，熔点164-166℃。
将1.0g(3.4mmol)该产物溶于少量乙腈，在催化量15-冠-5醚存在下与0.26g甲硫醇钠(3.4mmol)一起加热45分钟到70℃。然后将已冷却至室温的溶液用0.22g(5.5mmol)氢氧化钠和5ml水处理，继续搅拌3小时。随后用少量乙醚除去中性组分，调节水相的pH到2.5，用乙酸乙酯提取两次。由此得到2-甲硫基-6-三氟甲基烟酸结晶产物；1H-NMR(CDCl3)8.46，d，CH，7.43，d，CH，2.58ppm，s，SCH3.实施例H142-甲磺酰基氨基-6-三氟甲基烟酸(化合物A1203)向0.24g 55％氢化钠/油的四氢呋喃悬浮液内加入0.52g甲磺酰胺。待氢气逸出停止后，加入1.5g(5mmol)2-溴-6-三氟甲基烟酸乙酯、0.3g(5.2mmol)氟化钾和催化量冠醚以及5ml N-甲基吡咯烷酮，在沸腾状态下加热混合物18小时。然后将反应混合物分配到乙酸乙酯与水之间，除去有机中性组分。调节水相的pH至2.9，用新鲜乙酸乙酯提取三次，干燥并浓缩。自乙醚/己烷中得到结晶产物2-甲磺酰基氨基-6-三氟甲基烟酸乙酯；1H-NMR(CDCl3)10.48，s，NH，8.49，d，CH，7.38，d，CH，4.45，q，CH2，3.51，s，SO2CH3，1.42ppm，t，CH3.
利用0.22g(3.9mmol)氢氧化钾在二噁烷/水1∶1中的溶液室温水解0.43g(1.4mmol)上述产物。然后将溶液酸化至pH2.5，用乙酸乙酯提取处理，从而得到2-甲磺酰基氨基-6-三氟甲基烟酸结晶；1H-NMR(d6-DMSO)8.62，d，CH，7.72，d，CH，3.52ppm，s，SO2CH3.实施例H15溴化(3-甲氧基羰基-6-三氟甲基吡啶-2-基甲基)三苯基磷鎓在催化量α，α-偶氮(aza)异丁腈存在和150瓦的灯照射下，将50g(0.23mol) 2-甲基-6-三氟甲基烟酸甲酯和49g(0.28mol)N-溴代琥珀酰亚胺在500ml四氯化碳中50℃加热90分钟。滤去沉淀出的琥珀酰亚胺，然后利用柱色谱(流动相乙酸乙酯/己烷1∶15)分离得到主要组分2-溴甲基-6-三氟甲基烟酸甲酯产物，1H-NMR(CDCl3)4.01，s，3H；5.03，s，2H；7.72，d(J8.2Hz)，1H；8.43ppm，d，(J8.2Hz)，1H.将25.6g(35mmol)上述产物溶于甲苯，用10.6g(40mmol)三苯膦处理。沸腾加热混合物2小时后，冷却得到纯净的溴化(3-甲氧基羰基-6-三氟甲基吡啶-2-基甲基)三苯基磷鎓晶体，熔点215-217℃.实施例H162-乙烯基-6-三氟甲基烟酸(化合物A21)和2-(2，2-二氯环丙基)-6-三氟甲基烟酸(化合物A1092)室温下，将5.7g(10mmol)溴化(3-甲氧基羰基-6-三氟甲基吡啶-2-基甲基)三苯基磷鎓溶于25ml氯仿与2.1g(20mmol)碳酸钠构成的两相体系，在10ml水存在下与1.7g(20mmol)甲醛的35％水溶液反应。1.5小时后，分出有机相并通过硅胶过滤。得到2-乙烯基-6-三氟甲基烟酸甲酯油状物，1H-NMR(CDCl3)8.31，d，CH，7.10，dd，CH，7.09，d，CH，6.68，dd，CH，5.68，dd，CH，3.97ppm，s，OCH3.
取0.97g(4.1mmol)该产物再次溶于氯仿，在剧烈搅拌和有90mg溴化苄基三甲铵存在下与6ml 50％氢氧化钠溶液反应。20小时后，分出有机相，浓缩并通过HPLC纯化(流动相乙酸乙酯/己烷1∶4)。从而得到2-(2，2-二氯环丙基)-6-三氟甲基烟酸甲酯纯品，1H-NMR(CDCl3)8.50，d，CH，7.70，d，CH，4.08，s，OCH3，3.68，dd，CH，2.64，dd，CH，2.05ppm，dd，CH.
水解上述酯，从而得到2-乙烯基-6-三氟甲基烟酸，1H-NMR(CDCl3)8.40，d，CH，7.22，dd，CH，7.09，d，CH，6.68，dd，CH，5.58ppm，dd，CH，和2-(2，2-二氯环丙基)-6-三氟甲基烟酸，1H-NMR(CDCl3)8.64，d，CH，7.23，d，CH，3.78，dd，CH，2.67，dd，CH，2.08ppm，dd，CH.实施例H172-丙-1，2-二烯基-6-三氟甲基烟酸(A1096)和2-(3-氯丙烯基)-6-三氟甲基烟酸(化合物A1095)剧烈搅拌下，使6.7g(11mmol)溴化((3-甲氧基羰基-6-三氟甲基吡啶-2-基)甲基)三苯基磷鎓与2ml 45％氯乙醛水溶液(14mmol)和1.5g(14mmol)碳酸钠在20ml氯仿与7ml水构成的两相体系中反应。2小时后，分出有机溶液，用半饱和氯化钠溶液洗涤。产物通过硅胶分离(流动相乙酸乙酯/己烷1∶4)。分离得到的第一馏分为2-丙-1，2-二烯基-6-三氟甲基烟酸甲酯，1H-NMR(CDCl3)7.62，m，CH，7.55，d，CH，7.32，d，CH，7.04，d，CH，7.02，m，CH，3.98ppm，s，OCH3，分离得到的第二馏分为2-(3-氯丙烯基)-6-三氟甲基烟酸甲酯，1H-NMR(CDCl3)8.85，d，CH，7.65，dd，7.58，d，CH，CH，7.28，dd，CH，4.32，d，CH2Cl，3.98ppm，s，OCH3.
水解上述酯，得到2-丙-1，2-二烯基-6-三氟甲基烟酸，m.p.194-196℃，和2-(3-氯丙烯基)-6-三氟甲基烟酸，m.p.137-138℃.实施例H182-氯-4-甲基-6-三氟甲基烟酸(化合物A1205)在加压容器中，在5.8ml二氯磷酸苯酯存在下170℃加热7.5g(0.03mol)(3-乙氧基羰基)-4-甲基-6-三氟甲基)-吡啶-2-酮3小时。冷却后，反应溶液直接通过短硅胶柱过滤(流动相乙酸乙酯/己烷1∶9)，得到油状产物2-氯-4-甲基-6-三氟甲基吡啶-3-基乙基酯。在氢氧化钾水溶液存在下，在二噁烷中40℃水解后者。酸化至pH2.7后，用乙酸乙酯提取，得2-氯-4-甲基-6-三氟甲基烟酸结晶产物1H-NMR(CDCl3)9.55，b，OH，7.55，s，1H；3.80，s，CH3，2.56ppm.s.CH3.实施例H194-甲基-6-三氟甲基烟酸(化合物A531)向0.55g 10％ Pd/C在20ml甲醇中的悬浮液内加入3.0g(16.8mmol)2-氯-4-甲基-6-三氟甲基吡啶-3-基乙基酯，并分两批加入总量为5g的甲酸铵，然后室温搅拌混合物24小时。反应混合物随后通过Celite过滤，分配到乙酸乙酯与氯化钠溶液之内。层析纯化(流动相1∶9)得到油状形式4-甲基-6-三氟甲基吡啶-3-基乙基酯按照上述方法水解得到4-甲基-6-三氟甲基烟酸1H-NMR(CDCl3)9.32，s，1H，7.62，s，1H，2.79ppm，s，CH3.实施例H205-甲基-5-甲硫基二环[4.1.0]庚烷-2，4-二酮(化合物H-D113)0℃下，向13.4g(0.1mol)2-甲基巯基丙酸甲酯的30ml四氢呋喃溶液中加入1M双(三甲基甲硅烷基)氨化锂(16.7g，0.1mol)的四氢呋喃溶液。搅拌化合物1小时后，在20分钟内逐滴加入11.8g(0.1mol)5-氯戊-3-烯-2-酮，加料期间应保证温度仍为0℃。进一步搅拌混合物30分钟后，加入冰水，混合物用盐酸酸化，进而用乙酸乙酯提取。层析粗产物(乙酸乙酯/己烷15/85)。从而得到2-(2-乙酰基环丙基)-2-甲硫基丙酸甲酯，1H-NMR(CDCl3)3.74，s，OCH3，2.19和2.14，2s，SCH3，2.12.和2.00，2s，CH3，2.2-1.9，1H，1.3，s，CH3，1.3-1.0ppm，2H，系3∶7异构体混合物。
将2.45g(11mmol)富含高极性异构体的上述产物与溶在甲苯/二甲基甲酰胺19∶1混合物中的4.5g(25mmol)30％乙醇钠溶液一起115℃加热90分钟。混合物然后吸收到乙酸乙酯内，用pH3的稀盐酸洗涤。分离出的残留物通过硅胶纯化(流动相乙酸乙酯/己烷1∶2)。从而得到异构体I5-甲基-5-甲硫基二环[4.1.0]庚烷-2，4-二酮，1H-NMR(CDCl3)3.48，d，CH，3.00，d，CH，2.21，m，CH，1.94，m，CH，1.86，s，CH3，1.57，s，CH3，1.44，m，CH，1.04ppm，m，CH。
由富含非极性异构体的产物得到异构体II5-甲基-5-甲硫基二环[4.1.0]庚烷-2，4-二酮，1H-NMR(CDCl3)3.78，d，CH，3.14d，CH，2.22，m，CH，1.93，m，CH，2.08，s，CH3，1.58，s，CH3，1.6-1.4ppm，2H.实施例H214-甲基环庚-4-烯-1，3-二酮(化合物H-F5)在5g阮氏镍存在下，将1.0g(5.4mmol)5-甲基-5-甲硫基二环[4.1.0]庚烷-2，4-二酮异构体II在15ml甲醇中常压氢化90分钟。浓缩混合物并通过硅胶纯化(流动相乙酸乙酯/己烷1∶1)，得到4-甲基环庚-4-烯-1，3-二酮油状物，1H-NMR(CDCl3)6.84，m，CH，3.94，s，CH2，2.77，m，CH2，2.59，m，CH2，1.88ppm，s，CH3.实施例H222-氧杂螺[4.5]癸烷-1，6，8-三酮(化合物H-E16)冷却氢化钠(55％油分散物，27.5mmol)在70ml无水四氢呋喃中的悬浮液到-20℃，随后逐滴加入2-酰基丁内酯(2.69ml，25mmol)的5ml四氢呋喃溶液。在此温度下搅拌反应混合物1小时后，于-20℃滴加丙烯酸甲酯(4.5ml，50mmol)的四氢呋喃溶液进行处理。其后温热反应混合物至室温，搅拌8小时。混合物然后倒入冰水内，用2N盐酸酸化至pH1。经乙酸乙酯提取、硫酸钠干燥和真空浓缩后，将产物通过快速色谱纯化(洗脱剂乙酸乙酯/乙酸1∶1)。从而得到白色粉末形式2-氧杂螺[4.5]癸烷-1，6，8-三酮，熔点145-148℃.实施例H23螺[2.5]辛烷-4，6-二酮(化合物H-Cl)将3.4g氢化钠(55％油悬浮物，78.0mmol)加到11叔丁醇内，室温搅拌此混合物数分钟。然后加入2-酰基丁内酯(100g，0.78mol)，反应混合物在大约30℃下用丙烯酸甲酯(67.2g，0.78mmol)处理3.5小时。将反应混合物吸收到乙醚内，依次用75ml磷酸二氢钠饱和溶液、水以及氯化钠饱和溶液洗涤，硫酸钠干燥并浓缩。从而得到162g无色油状物3-(3-乙酰基-2-氧代四氢呋喃-3-基)丙酸甲酯，该产物无需进一步纯化可直接使用。
将2.0g(9.3mmol)上述产物和2.1g碘化钠(14.0mmol)溶于10ml1，3-二甲基-2-咪唑烷酮，210℃加热此溶液3小时。冷却后，将反应混合物倒入磷酸二氢钠稀水溶液内，用乙醚提取，硫酸钠干燥并浓缩。从而得到3-(1-乙酰基环丙基)丙酸甲酯无色油状物。
将74.5g 3-(1-乙酰基环丙基)丙酸甲酯(0.32mol)溶于11四氢呋喃，并将该溶液在室温下用14.3g氢化钠(55％油悬浮物，0.32mol)分批处理。1小时后，反应混合物用200ml二甲基甲酰胺稀释，然后温热到70℃。8小时后，真空除去四氢呋喃，残留物倒入2N盐酸内，用乙醚提取。硫酸钠干燥有机相并浓缩，经硅胶柱层析(二氯甲烷∶甲醇9∶1作为洗脱剂)得到螺[2.5]辛烷-4，6-二酮，系白色结晶，熔点116-118℃。实施例H242-(4，6-二甲氧基嘧啶-2-基硫基甲基)-6-三氟甲基烟酸(化合物A1088)在30ml乙腈和1.63g(11.83mmol)K2CO3中加入2.0g(7.89mmol)2-氯甲基-6-三氟甲基烟酸甲酯(类似Heterocycles，46，129(1997)所述，在三氟乙酸存在下，在甲苯中加热4-氯-3-氧代丁酸甲酯与4-氨基-1，1，1-三氟丁-3-烯-2-酮制得)，与1.49g(8.67mmol)4，6-二甲氧基嘧啶-2-硫醇在室温下反应。4小时后，将混合物倒入乙酸乙酯/水中，移出乙酸乙酯相，水相用乙酸乙酯再提取。合并的乙酸乙酯相用硫酸钠干燥，浓缩并在乙酸乙酯/己烷中重结晶，从而得2-(4，6-二甲氧基嘧啶-2-基硫基甲基)-6-三氟甲基烟酸甲酯白色结晶，熔点123-124℃。
水解(类似实施例H1)上述酯，从而得到白色结晶2-(4，6-二甲氧基嘧啶-2-基硫基甲基)-6-三氟甲基烟酸，熔点157-158℃。1H-NMR(CDCl3)3.96，s，6H；3.99，s，3H；5.03，s，2H；5.72，s，1H；7.66，d(J，8.1Hz)，1H；8.40ppm，d(J，8.1Hz)，1H.实施例H252-氰基甲基-6-三氟甲基烟酸(化合物A1103)
在270mg四丁基硫酸氢铵存在下，使2.0g(7.89mmol)2-氯甲基-6-三氟甲基烟酸甲酯与565mg(8.67mmol)氰化钾在20ml乙腈/水混合液(1∶1)中反应。反应结束后，将混合物倒入水中，用乙酸乙酯提取。乙酸乙酯相用硫酸钠干燥，浓缩后得到的粗产物进而用HPLC纯化(乙酸乙酯∶己烷为洗脱剂)。从而得到610mg(32％理论产率)2-氰甲基-6-三氟甲基烟酸甲酯油状物。1H-NMR(CDCl3)3.96，s，3H；4.38，s，2H；7.72，d(J，8.1Hz)，1H；8.48ppm，d(J，8.1Hz)，1H.
采用上文早已描述过的类似方法进行水解，从而得到2-氰甲基-6-三氟甲基烟酸黄色晶体，熔点152-153℃。1H-NMR(CDCl3)4.18，s，2H；7.72，d(J，8.1Hz)，1H；8.52ppm，d(J，8.1Hz)，1H.实施例H263-(6-二氟甲基-2-甲基吡啶-3-羰基)-2-羟基-1-甲基-4-氧代环己-2-烯羧酸甲酯(化合物A124-B34)在0.18ml(0.62mmol)三(三甲基甲硅烷基)硅烷存在下，在8ml甲苯中于120℃加热200mg(0.516mmol)3-[6-(氯二氟甲基)-2-甲基吡啶-3-羰基]-2-羟基-1-甲基-4-氧代环己-2-烯羧酸甲酯(化合物A94-B34)3小时。硅胶层析剩余的粘性残留物。将用甲苯、乙醇、二噁烷、三乙胺与水的混合液(100∶40∶20∶20∶5，体积比)洗脱得到的浅黄色粘性油状物溶于二氯甲烷，依次用盐酸水溶液和水洗涤。蒸发经硫酸钠干燥后的有机溶液，得140mg(73％)3-(6-二氟甲基-2-甲基吡啶-3-羰基)-2-羟基-1-甲基-4-氧代环己-2-烯羧酸甲酯纯品，系浅黄色油状物。1H-NMR(CDCl3)1.28，s，3H；1.79-1.97，m，1H；2.39-2.46，m，1H；2.43，s，3H；2.69，dt(J，19.2和4.8Hz)，1H；2.82-2.92，m，1H；3.67，s，3H；6.55，t，(J，55.5Hz)，1H；7.43，d(J，7.8Hz)，1H；7.49，d(J，7.8Hz)，1H；17.20ppm，br s，1H.实施例H273-羟基-2-(2-甲基-1-氧-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(化合物A1210-B1)将16.1g(0.054mol)3-羟基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(实施例A2-B1)和10.2g(0.11mol)脲/过氧化氢复合物溶于150ml二氯甲烷，随后在25℃下加入22.1ml(0.162mol)三氟乙酸酐。25℃搅拌反应混合物14小时后，倒入乙酸乙酯和水中，水洗有机相两次，硫酸钠干燥并浓缩。硅胶层析残留物(洗脱剂∶乙酸乙酯/甲醇9/1)。得到2.4g(14％)所需产物，白色结晶(m.p.117-119℃).
1H-NMR(d6-DMSO)1.98，m，2H；2.30，s，3H；2.60，t(J，7.25Hz)，4H7.32，d(J，9.8Hz)，1H；7.92ppm，d(J，9.8Hz)，1H.实施例H282-(2-甲基-6-三氟甲基吡啶-3-羰基)-3-苯硫基环己-2-烯酮(化合物A2-B1102)将4.0g(0.0134mol)3-羟基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(化合物A2-B1)悬浮于25ml草酰氯，随后逐滴加入0.1ml二甲基甲酰胺。待大量气体逸出停止后，在45℃浴温下保持混合物1.5小时，其后浓缩，并将残留物(3-氯-2-(2-甲基-6-三氟甲基吡啶-3-羰基)-环己-2-烯酮)溶于60ml二氯甲烷。在0-5℃下加入三乙胺(3.7ml，0.0268mol)、二甲氨基吡啶(160mg，1.34mmol)以及1.5ml(0.0147mol)苯硫酚。22℃反应20小时后，浓缩反应混合物，进而通过硅胶纯化(己烷/乙酸乙酯5∶1)。用己烷研制得纯净2-(2-甲基-6-三氟甲基吡啶-3-羰基)-3-苯硫基环己-2-烯酮，白色结晶体，熔点124-125℃.1H-NMR(CDCl3)1.99，m，2H；2.41，m 4H；2.80，s，3H；2.607.40-7.60，m，6H；7.80ppm，d(J，8.2Hz)，1H.实施例H293-苯磺酰基-2-(2-甲基-6-三氟甲基吡啶-3-羰基)环己-2-烯酮(化合物A2-B1104)将上面得到的0.8g(0.00204mol)2-(2-甲基-6-三氟甲基吡啶-3-羰基)-3-苯硫基环己-2-烯酮溶于30ml二氯甲烷，随后在25℃逐滴加入1.39ml过乙酸(39％乙酸，0.00816mol)。25℃反应4小时后，将反应混合物倒入乙酸乙酯与水内，水洗有机相，硫酸钠干燥并浓缩，残留物用少量己烷和乙酸乙酯研制。过滤得到0.72g(84％理论产率)3-苯磺酰基-2-(2-甲基-6-三氟甲基-吡啶-3-羰基)环己-2-烯酮，白色结晶，熔点165-167℃.
1H-NMR(CDCl3)2.30，m，2H；2.55，t(J，7Hz)，2H；2.71，m，2H；3.05，s，3H；7.40-7.80，m，4H；7.80-8.05ppm，m，3H.实施例H306-二氟甲基-2-甲基烟酸(化合物A124)在430mg(0.26mol)三(三甲基甲硅烷基)硅烷存在下，在150ml甲苯中120℃加热6.1g(0.026mol)6-(氯二氟甲基)-2-甲基烟酸甲酯(后者按照Heterocycles，46，129(1997)所述的类似方法，在三氟乙酸存在下，在甲苯中加热3-氧代丁酸甲酯与4-氨基-1-氯-1，1-二氟丁-3-烯-2-酮制得)。1.5小时后，浓缩反应混合物，进而通过硅胶纯化(己烷/乙酸乙酯13∶1)。得到3.8g(73％理论产率)6-二氟甲基-2-甲基烟酸甲酯，系无色油状物。
水解(类似于实施例H1)上述酯，从而得到白色结晶形式6-二氟甲基-2-甲基烟酸，熔点135-136℃.
1H-NMR(CDCl3)2.68，s，3H；6.583，t(J，55.2Hz)，1H；7.54，d(J，8.1Hz)，1H；7.54ppm，d(J，8.1Hz)，1H.实施例H316-(氯二氟甲基)-2-甲基烟酸(化合物A-94)在加压容器中冷却5.0g(18.62mmol)2-甲基-6-三氯甲基烟酸甲酯(类似Heterocycles，46，129(1997)所述制得)至-40℃，随后在此温度下加入35g(1.75mol)蒸馏过的氢氟酸。200℃加热混合物10小时(压力大约55巴)。冷却后，利用气体-洗涤系统解除压力。抽吸除去HF，其后将反应混合物倒入乙酸乙酯/冰中。分出乙酸乙酯相，水相用乙酸乙酯再提取。然后水洗合并的乙酸乙酯相，硫酸钠干燥并浓缩，残留物进而用少量己烷和乙酸乙酯研制。过滤得到2.2g(53％理论产率)6-氯二氟甲基-2-甲基烟酸，浅绿色结晶，熔点134-135℃。1H-NMR(CDCl3)2.987，s，3H；7.64，d(J，8.1Hz)，1H；8.513ppm，d(J，8.1Hz)，1H.实施例H322-[2-(4，6-二甲氧基嘧啶-2酰基甲基)-6-三氟甲基吡啶-3-羰基]-3-羟基环己-2-烯酮(化合物A1090-B1)将100mg 2-[2-(4，6-二甲氧基嘧啶-2-基硫基甲基)-6-三氟甲基吡啶-3-羰基]-3-羟基环己-2-烯酮(化合物A1088-B1)溶于二氯甲烷，随后在25℃下逐滴加入0.3ml过乙酸(39％乙酸溶液)。25℃反应15小时后，将反应混合物倒入乙酸乙酯与水中，有机相用水洗涤、硫酸钠干燥并浓缩。从而得到95mg树脂状2-[2-(4，6-二甲氧基嘧啶-2-磺酰基甲基)-6-三氟甲基吡啶-3-羰基]-3-羟基环己-2-烯酮。1H-NME(CDCl3)3.79，s，6H；3.91，s，3H；4.99，s，2H；6.09，s，1H；7.52，d(J，9Hz)，1H；7.68ppm，d(J，9Hz)，1H.
下列各表中，Ph代表苯基，且CC代表乙炔基。表1式XVId化合物 化合物序号 R2R3R4R5pA1 HHHCF30A2CH3HHCF30A3CH3CH2HHCF30A4(CH3)2CH HHCF30A5(CH3)3C HHCF30A6环丙基 HHCF30A7CH3(CH2)2HHCF30化合物序号R2R3R4R5pA8CH3OCH2HHCF30A9CH3O(CH2)2HHCF30A10 Ph HHCF30A11 PhOHHCF30A12 PhSHHCF30A13 PhSO HHCF30A14 PhSO2HHCF30A15 CH3S HHCF30A16 CH3SOHHCF30A17 CF3HHCF30A18 F2CH HHCF30A19 HCC HHCF30A20 CH3CCHHCF30A21 CH2＝CH HHCF30A22 CH2＝CHCH2HHCF30A23 CH3SO2N(CH3) HHCF30A24 (CH3)2N HHCF30A25 (CH3)2NSO2HHCF30A26 ClCH2HHCF30A27 CH3SCH2HHCF30A28 CH3SOCH2HHCF30A29 CH3SO2CH2HHCF30A30 [1.2.4]-三唑-1-基甲基 HHCF30A31 CH3CF3HCH30A32 CH3CH3HCF30A33 H HHCF3CF20A34 CH3HHCF3CF20A35 CH3CH2HHCF3CF20A36 环丙基 HHCF3CF20A37 (CH3)3C HHCF3CF20A38 (CH3)2CH HHCF3CF20A39 CH3(CH2)2HHCF3CF20A40 CH3OCH2HHCF3CF20化合物序号 R2R3R4R5pA41 CH3O(CH2)2HHCF3CF20A42 PhHHCF3CF20A43 PhO HHCF3CF20A44 PhS HHCF3CF20A45 PhSO HHCF3CF20A46 PhSO2HHCF3CF20A47 CH3S HHCF3CF20A48 CH3SOHHCF3CF20A49 CF3HHCF3CF20A50 F2CH HHCF3CF20A51 HCC HHCF3CF20A52 CH3CCHHCF3CF20A53 CH2＝CH HHCF3CF20A54 CH2＝CHCH2HHCF3CF20A55 CH3SO2N(CH3) HHCF3CF20A56 (CH3)2N HHCF3CF20A57 (CH3)2NSO2HHCF3CF20A58 ClCH2HHCF3CF20A59 CH3SCH2HHCF3CF20A60 CH3SOCH2HHCF3CF20A61 CH3SO2CH2HHCF3CF20A62 [1.2.4]-三唑-1-基甲基 HHCF3CF20A63 H HHCF3CF2CF20A64 CH3HHCF3CF2CF20A65 CH3CH2HHCF3CF2CF20A66 环丙基 HHCF3CF2CF20A67 (CH3)3C HHCF3CF2CF20A68 (CH3)2CHHHCF3CF2CF20A69 CH3(CH2)2HHCF3CF2CF20A70 CH3OCH2HHCF3CF2CF20A71 CH3O(CH2)2HHCF3CF2CF20A72 Ph HHCF3CF2CF20A73 PhOHHCF3CF2CF20化合物序号R2R3R4R5pA74 PhS HHCF3CF2CF20A75 PhSO HHCF3CF2CF20A76 PhSO2HHCF3CF2CF20A77 CH3S HHCF3CF2CF20A78 CH3SOHHCF3CF2CF20A79 CF3HHCF3CF2CF20A80 F2CH HHCF3CF2CF20A81 HCC HHCF3CF2CF20A82 CH3CCHHCF3CF2CF20A83 CH2＝CH HHCF3CF2CF20A84 CH2＝CHCH2HHCF3CF2CF20A85 CH3SO2N(CH3) HHCF3CF2CF20A86 (CH3)2N HHCF3CF2CF20A87 (CH3)2NSO2HHCF3CF2CF20A88 ClCH2HHCF3CF2CF20A89 CH3SCH2HHCF3CF2CF20A90 CH3SOCH2HHCF3CF2CF20A91 CH3SO2CH2HHCF3CF2CF20A92 [1.2.4]-三唑-1-基甲基 HHCF3CF2CF20A93 H HHCF2Cl0A94 CH3HHCF2Cl0A95 CH3CH2HHCF2Cl0A96 环丙基 HHCF2Cl0A97 (CH3)3C HHCF2Cl0A98 (CH3)2CHHHCF2Cl0A99 CH3(CH2)2HHCF2Cl0A100 CH3OCH2HHCF2Cl0A101 CH3O(CH2)2HHCF2Cl0A102 Ph HHCF2Cl0A103 PhOHHCF2Cl0A104 PhSHHCF2Cl0A105 PhSO HHCF2Cl0A106 PhSO2HHCF2Cl0化合物序号R2R3R4R5pA107 CH3SHHCF2Cl0A108 CH3SO HHCF2Cl0A109 CF3HHCF2Cl0A110 F2CHHHCF2Cl0A111 HCC HHCF2Cl0A112 CH3CC HHCF2Cl0A113 CH2＝CH HHCF2Cl0A114 CH2＝CHCH2HHCF2Cl0A115 CH3SO2N(CH3) HHCF2Cl0A116 (CH3)2NHHCF2Cl0A117 (CH3)2NSO2HHCF2Cl0A118 ClCH2HHCF2Cl0A119 CH3SCH2HHCF2Cl0A120 CH3SOCH2HHCF2Cl0A121 CH3SO2CH2HHCF2Cl0A122 [1.2.4]-三唑-1-基甲基 HHCF2Cl0A123 H HHCHF20A124 CH3HHCHF20A125 CH3CH2HHCHF20A126 环丙基HHCHF20A127 (CH3)3CHHCHF20A128 (CH3)2CH HHCHF20A129 CH3(CH2)2HHCHF20A130 CH3OCH2HHCHF20A131 CH3O(CH2)2HHCHF20A132 PhHHCHF20A133 PhO HHCHF20A134 PhS HHCHF20A135 PhSO HHCHF20A136 PhSO2HHCHF20A137 CH3S HHCHF20A138 CH3SOHHCHF20A139 CF3HHCHF20化合物序号R2R3R4R5pA140 F2CHHHCHF20A141 HCC HHCHF20A142 CH3CC HHCHF20A143 CH2＝CH HHCHF20A144 CH2＝CHCH2HHCHF20A145 CH3SO2N(CH3) HHCHF20A146 (CH3)2NHHCHF20A147 (CH3)2NSO2HHCHF20A148 ClCH2HHCHF20A149 CH3SCH2HHCHF20A150 CH3SOCH2HHCHF20A151 CH3SO2CH2HHCHF20A152 [1.2.4]-三唑-1-基甲基HHCHF20A153 HHHCCl30A154 CH3HHCCl30A155 CH3CH2HHCCl30A156 环丙基 HHCCl30A157 (CH3)3CHHCCl30A158 (CH3)2CH HHCCl30A159 CH3(CH2)2HHCCl30A160 CH3OCH2HHCCl30A161 CH3O(CH2)2HHCCl30A162 Ph HHCCl30A163 PhO HHCCl30A164 PhS HHCCl30A165 PhSO HHCCl30A166 PhSO2HHCCl30A167 CH3SHHCCl30A168 CH3SO HHCCl30A169 CF3HHCCl30A170 F2CHHHCCl30A171 HCC HHCCl30A172 CH3CC HHCCl30化合物序号 R2R3R4R5pA173CH2＝CH HH CCl30A174CH2＝CHCH2HH CCl30A175CH3SO2N(CH3) HH CCl30A176(CH3)2NHH CCl30A177(CH3)2NSO2HH CCl30A178ClCH2HH CCl30A179CH3SCH2HH CCl30A180CH3SOCH2HH CCl30A181CH3SO2CH2HH CCl30A182[1.2.4]-三唑-1-基甲基HH CCl30A183HHCH3CF30A184CH3HCH3CF30A185CH3CH2HCH3CF30A186环丙基 HCH3CF30A187(CH3)3CHCH3CF30A188(CH3)2CH HCH3CF30A189CH3(CH2)2HCH3CF30A190CH3OCH2HCH3CF30A191CH3O(CH2)2HCH3CF30A192Ph HCH3CF30A193PhO HCH3CF30A194PhS HCH3CF30A195PhSO HCH3CF30A196PhSO2HCH3CF30A197CH3SHCH3CF30A198CH3SO HCH3CF30A199CF3HCH3CF30A200F2CHHCH3CF30A201HCC HCH3CF30A202CH3CC HCH3CF30A203CH2＝CH HCH3CF30A204CH2＝CHCH2HCH3CF30A205CH3SO2N(CH3) HCH3CF30化合物序号 R2R3R4R5pA206(CH3)2N HCH3CF30A207(CH3)2NSO2HCH3CF30A208ClCH2HCH3CF30A209CH3SCH2HCH3CF30A210CH3SOCH2HCH3CF30A211CH3SO2CH2HCH3CF30A212H HCH3CF3CF20A213CH3HCH3CF3CF20A214CH3CH2HCH3CF3CF20A215环丙基 HCH3CF3CF20A216(CH3)3C HCH3CF3CF20A217(CH3)2CH HCH3CF3CF20A218CH3(CH2)2HCH3CF3CF20A219CH3OCH2HCH3CF3CF20A220CH3O(CH2)2HCH3CF3CF20A221Ph HCH3CF3CF20A222PhO HCH3CF3CF20A223PhS HCH3CF3CF20A224PhSOHCH3CF3CF20A225PhSO2HCH3CF3CF20A226CH3S HCH3CF3CF20A227CH3SO HCH3CF3CF20A228CF3HCH3CF3CF20A229F2CH HCH3CF3CF20A230HCC HCH3CF3CF20A231CH3CC HCH3CF3CF20A232CH2＝CHHCH3CF3CF20A233CH2＝CHCH2HCH3CF3CF20A234CH3SO2N(CH3) HCH3CF3CF20A235(CH3)2N HCH3CF3CF20A236(CH3)2NSO2HCH3CF3CF20A237ClCH2HCH3CF3CF20A238CH3SCH2HCH3CF3CF20化合物序号R2R3R4R5pA239 CH3SOCH2HCH3CF3CF20A240 CH3SO2CH2HCH3CF3CF20A241 H HCH3CF3CF2CF20A242 CH3HCH3CF3CF2CF20A243 CH3CH2HCH3CF3CF2CF20A244 环丙基 HCH3CF3CF2CF20A245 (CH3)3C HCH3CF3CF2CF20A246 (CH3)2CHHCH3CF3CF2CF20A247 CH3(CH2)2HCH3CF3CF2CF20A248 CH3OCH2HCH3CF3CF2CF20A249 CH3O(CH2)2HCH3CF3CF2CF20A250 Ph HCH3CF3CF2CF20A251 PhOHCH3CF3CF2CF20A252 PhSHCH3CF3CF2CF20A253 PhSO HCH3CF3CF2CF20A254 PhSO2HCH3CF3CF2CF20A255 CH3S HCH3CF3CF2CF20A256 CH3SO HCH3CF3CF2CF20A257 CF3HCH3CF3CF2CF20A258 F2CH HCH3CF3CF2CF20A259 HCCHCH3CF3CF2CF20A260 CH3CC HCH3CF3CF2CF20A261 CH2＝CH HCH3CF3CF2CF20A262 CH2＝CHCH2HCH3CF3CF2CF20A263 CH3SO2N(CH3)HCH3CF3CF2CF20A264 (CH3)2N HCH3CF3CF2CF20A265 (CH3)2NSO2HCH3CF3CF2CF20A266 ClCH2HCH3CF3CF2CF20A267 CH3SCH2HCH3CF3CF2CF20A268 CH3SOCH2HCH3CF3CF2CF20A269 CH3SO2CH2HCH3CF3CF2CF20A270 H HCH3CF2Cl 0A271 CH3HCH3CF2Cl 0化合物序号R2R3R4R5pA272 CH3CH2HCH3CF2Cl0A273 环丙基 HCH3CF2Cl0A274 (CH3)3C HCH3CF2Cl0A275 (CH3)2CH HCH3CF2Cl0A276 CH3(CH2)2HCH3CF2Cl0A277 CH3OCH2HCH3CF2Cl0A278 CH3O(CH2)2HCH3CF2Cl0A279 Ph HCH3CF2Cl0A280 PhOHCH3CF2Cl0A281 PhSHCH3CF2Cl0A282 PhSO HCH3CF2Cl0A283 PhSO2HCH3CF2Cl0A284 CH3S HCH3CF2Cl0A285 CH3SO HCH3CF2Cl0A286 CF3HCH3CF2Cl0A287 F2CH HCH3CF2Cl0A288 HCCHCH3CF2Cl0A289 CH3CC HCH3CF2Cl0A290 CH2＝CH HCH3CF2Cl0A291 CH2＝CHCH2HCH3CF2Cl0A292 CH3SO2N(CH3)HCH3CF2Cl0A293 (CH3)2N HCH3CF2Cl0A294 (CH3)2NSO2HCH3CF2Cl0A295 ClCH2HCH3CF2Cl0A296 CH3SCH2HCH3CF2Cl0A297 CH3SOCH2HCH3CF2Cl0A298 CH3SO2CH2HCH3CF2Cl0A299 H HCH3CHF20A300 CH3HCH3CHF20A301 CH3CH2HCH3CHF20A302 环丙基 HCH3CHF20A303 (CH3)3C HCH3CHF20A304 (CH3)2CH HCH3CHF20化合物序号R2R3R4R5pA305 CH3(CH2)2HCH3CHF20A306 CH3OCH2HCH3CHF20A307 CH3O(CH2)2HCH3CHF20A308 Ph HCH3CHF20A309 PhO HCH3CHF20A310 PhS HCH3CHF20A311 PhSOHCH3CHF20A312 PhSO2HCH3CHF20A313 CH3S HCH3CHF20A314 CH3SO HCH3CHF20A315 CF3HCH3CHF20A316 F2CH HCH3CHF20A317 HCC HCH3CHF20A318 CH3CC HCH3CHF20A319 CH2＝CHHCH3CHF20A320 CH2＝CHCH2HCH3CHF20A321 CH3SO2N(CH3) HCH3CHF20A322 (CH3)2N HCH3CHF20A323 (CH3)2NSO2HCH3CHF20A324 ClCH2HCH3CHF20A325 CH3SCH2HCH3CHF20A326 CH3SOCH2HCH3CHF20A327 CH3SO2CH2HCH3CHF20A328 HHCH3CCl30A329 CH3HCH3CCl30A330 CH3CH2HCH3CCl30A331 (CH3)3C HCH3CCl30A332 (CH3)2CH HCH3CCl30A333 环丙基 HCH3CCl30A334 CH3(CH2)2HCH3CCl30A335 CH3OCH2HCH3CCl30A336 CH3O(CH2)2HCH3CCl30A337 Ph HCH3CCl30化合物序号R2R3R4R5pA338 PhO HCH3CCl30A339 PhS HCH3CCl30A340 PhSOHCH3CCl30A341 PhSO2HCH3CCl30A342 CH3S HCH3CCl30A343 CH3SO HCH3CCl30A344 CF3HCH3CCl30A345 F2CH HCH3CCl30A346 HCC HCH3CCl30A347 CH3CC HCH3CCl30A348 CH2＝CHHCH3CCl30A349 CH2＝CHCH2HCH3CCl30A350 CH3SO2N(CH3) HCH3CCl30A351 (CH3)2N HCH3CCl30A352 (CH3)2NSO2HCH3CCl30A353 ClCH2HCH3CCl30A354 CH3SCH2HCH3CCl30A355 CH3SOCH2HCH3CCl30A356 CH3SO2CH2HCH3CCl30A357 HHPh CF30A358 CH3HPh CF30A359 CH3CH2HPh CF30A360 环丙基 HPh CF30A361 (CH3)3C HPh CF30A362 (CH3)2CH HPh CF30A363 CH3(CH2)2HPh CF30A364 CH3OCH2HPh CF30A365 CH3O(CH2)2HPh CF30A366 Ph HPh CF30A367 PhO HPh CF30A368 PhS HPh CF30A369 PhSO HPh CF30A370 PhSO2HPh CF30化合物序号R2R3R4R5pA371 CH3S HPhCF30A372 CH3SO HPhCF30A373 CF3HPhCF30A374 F2CH HPhCF30A375 HCC HPhCF30A376 CH3CC HPhCF30A377 CH2＝CHHPhCF30A378 CH2＝CHCH2HPhCF30A379 CH3SO2N(CH3) HPhCF30A380 (CH3)2N HPhCF30A381 (CH3)2NSO2HPhCF30A382 ClCH2HPhCF30A383 CH3SCH2HPhCF30A384 CH3SOCH2HPhCF30A385 CH3SO2CH2HPhCF30A386 HHPhCF3CF20A387 CH3HPhCF3CF20A388 CH3CH2HPhCF3CF20A389 环丙基 HPhCF3CF20A390 (CH3)3C HPhCF3CF20A391 (CH3)2CH HPhCF3CF20A392 CH3(CH2)2HPhCF3CF20A393 CH3OCH2HPhCF3CF20A394 CH3O(CH2)2HPhCF3CF20A395 Ph HPhCF3CF20A396 PhO HPhCF3CF20A397 PhS HPhCF3CF20A398 PhSO HPhCF3CF20A399 PhSO2HPhCF3CF20A400 CH3SHPhCF3CF20A401 CH3SO HPhCF3CF20A402 CF3HPhCF3CF20A403 F2CHHPhCF3CF20化合物序号R2R3R4R5pA404 HCC HPhCF3CF20A405 CH3CC HPhCF3CF20A406 CH2＝CHHPhCF3CF20A407 CH2＝CHCH2HPhCF3CF20A408 CH3SO2N(CH3) HPhCF3CF20A409 (CH3)2N HPhCF3CF20A410 (CH3)2NSO2HPhCF3CF20A411 ClCH2HPhCF3CF20A412 CH3SCH2HPhCF3CF20A413 CH3SOCH2HPhCF3CF20A414 CH3SO2CH2HPhCF3CF20A415 H HPhCF3CF2CF20A416 CH3HPhCF3CF2CF20A417 CH3CH2HPhCF3CF2CF20A418 环丙基 HPhCF3CF2CF20A419 (CH3)3C HPhCF3CF2CF20A420 (CH3)2CH HPhCF3CF2CF20A421 CH3(CH2)2HPhCF3CF2CF20A422 CH3OCH2HPhCF3CF2CF20A423 CH3O(CH2)2HPhCF3CF2CF20A424 Ph HPhCF3CF2CF20A425 PhO HPhCF3CF2CF20A426 PhS HPhCF3CF2CF20A427 PhSOHPhCF3CF2CF20A428 PhSO2HPhCF3CF2CF20A429 CH3S HPhCF3CF2CF20A430 CH3SO HPhCF3CF2CF20A431 CF3HPhCF3CF2CF20A432 F2CH HPhCF3CF2CF20A433 HCC HPhCF3CF2CF20A434 CH3CC HPhCF3CF2CF20A435 CH2＝CHHPhCF3CF2CF20A436 CH2＝CHCH2HPhCF3CF2CF20化合物序号R2R3R4R5pA437 CH3SO2N(CH3)HPhCF3CF2CF20A438 (CH3)2N HPhCF3CF2CF20A439 (CH3)2NSO2HPhCF3CF2CF20A440 ClCH2HPhCF3CF2CF20A441 CH3SCH2HPhCF3CF2CF20A442 CH3SOCH2HPhCF3CF2CF20A443 CH3SO2CH2HPhCF3CF2CF20A444 H HPhCF2Cl 0A445 CH3HPhCF2Cl 0A446 CH3CH2HPhCF2Cl 0A447 环丙基 HPhCF2Cl 0A448 (CH3)3C HPhCF2Cl 0A449 (CH3)2CH HPhCF2Cl 0A450 CH3(CH2)2HPhCF2Cl 0A451 CH3OCH2HPhCF2Cl 0A452 CH3O(CH2)2HPhCF2Cl 0A453 Ph HPhCF2Cl 0A454 PhO HPhCF2Cl 0A455 PhS HPhCF2Cl 0A456 PhSOHPhCF2Cl 0A457 PhSO2HPhCF2Cl 0A458 CH3S HPhCF2Cl 0A459 CH3SO HPhCF2Cl 0A460 CF3HPhCF2Cl 0A461 F2CH HPhCF2Cl 0A462 HCC HPhCF2Cl 0A463 CH3CC HPhCF2Cl 0A464 CH2＝CHHPhCF2Cl 0A465 CH2＝CHCH2HPhCF2Cl 0A466 CH3SO2N(CH3) HPhCF2Cl 0A467 (CH3)2N HPhCF2Cl 0A468 (CH3)2NSO2HPhCF2Cl 0A469 ClCH2HPhCF2Cl 0化合物序号R2R3R4R5pA470 CH3SCH2HPhCF2Cl 0A471 CH3SOCH2HPhCF2Cl 0A472 CH3SO2CH2HPhCF2Cl 0A473 H HPhCHF20A474 CH3HPhCHF20A475 CH3CH2HPhCHF20A476 环丙基 HPhCHF20A477 (CH3)3C HPhCHF20A478 (CH3)2CHHPhCHF20A479 CH3(CH2)2HPhCHF20A480 CH3OCH2HPhCHF20A481 CH3O(CH2)2HPhCHF20A482 Ph HPhCHF20A483 PhOHPhCHF20A484 PhSHPhCHF20A485 PhSO HPhCHF20A486 PhSO2HPhCHF20A487 CH3S HPhCHF20A488 CH3SO HPhCHF20A489 CF3HPhCHF20A490 F2CH HPhCHF20A491 HCCHPhCHF20A492 CH3CC HPhCHF20A493 CH2＝CH HPhCHF20A494 CH2＝CHCH2HPhCHF20A495 CH3SO2N(CH3)HPhCHF20A496 (CH3)2N HPhCHF20A497 (CH3)2NSO2HPhCHF20A498 ClCH2HPhCHF20A499 CH3SCH2HPhCHF20A500 CH3SOCH2HPhCHF20A501 CH3SO2CH2HPhCHF20A502 H HPhCCl30化合物序号R2R3R4R5pA503 CH3H PhCCl30A504 CH3CH2H PhCCl30A505 环丙基 H PhCCl30A506 (CH3)3C H PhCCl30A507 (CH3)2CH H PhCCl30A508 CH3(CH2)2H PhCCl30A509 CH3OCH2H PhCCl30A510 CH3O(CH2)2H PhCCl30A511 Ph H PhCCl30A512 PhO H PhCCl30A513 PhS H PhCCl30A514 PhSOH PhCCl30A515 PhSO2H PhCCl30A516 CH3S H PhCCl30A517 CH3SO H PhCCl30A518 CF3H PhCCl30A519 F2CH H PhCCl30A520 HCC H PhCCl30A521 CH3CC H PhCCl30A522 CH2＝CHH PhCCl30A523 CH2＝CHCH2H PhCCl30A524 CH3SO2N(CH3) H PhCCl30A525 (CH3)2N H PhCCl30A526 (CH3)2NSO2H PhCCl30A527 ClCH2H PhCCl30A528 CH3SCH2H PhCCl30A529 CH3SOCH2H PhCCl30A530 CH3SO2CH2H PhCCl30A531 H CH3HCF30A532 H CH3CH2HCF30A533 H 环丙基HCF30A534 H (CH3)3CH HCF30A535 H (CH3)2CH HCF30化合物序号R2R3R4R5pA536 HCH3(CH2)2HCF30A537 HCH3OCH2HCF30A538 HCH3O(CH2)2HCF30A539 HPh HCF30A540 HPhOHCF30A541 HPhSHCF30A542 HPhSO HCF30A543 HPhSO2HCF30A544 HCH3S HCF30A545 HCH3SO HCF30A546 HCF3HCF30A547 HF2CH HCF30A548 HHCCHCF30A549 HCH3CC HCF30A550 HCH2＝CH HCF30A551 HCH2＝CHCH2HCF30A552 HCH3SO2N(CH3)HCF30A553 H(CH3)2N HCF30A554 H(CH3)2NSO2HCF30A555 HCH3SCH2HCF30A556 HCH3SOCH2HCF30A557 HCH3SO2CH2HCF30A558 HCH3HCF3CF20A559 HCH3CH2HCF3CF20A560 H环丙基 HCF3CF20A561 H(CH3)3C HCF3CF20A562 H(CH3)2CH HCF3CF20A563 HCH3(CH2)2HCF3CF20A564 HCH3OCH2HCF3CF20A565 HCH3O(CH2)2HCF3CF20A566 HPh HCF3CF20A567 HPhO HCF3CF20A568 HPhS HCF3CF20化合物序号R2R3R4R5pA569 HPhSOHCF3CF20A570 HPhSO2HCF3CF20A571 HCH3S HCF3CF20A572 HCH3SO HCF3CF20A573 HCF3HCF3CF20A574 HF2CH HCF3CF20A575 HHCC HCF3CF20A576 HCH3CC HCF3CF20A577 HCH2＝CHHCF3CF20A578 HCH2＝CHCH2HCF3CF20A579 HCH3SO2N(CH3) HCF3CF20A580 H(CH3)2N HCF3CF20A581 H(CH3)2NSO2HCF3CF20A582 HCH3SCH2HCF3CF20A583 HCH3SOCH2HCF3CF20A584 HCH3SO2CH2HCF3CF20A585 HCH3HCF3CF2CF20A586 HCH3CH2HCF3CF2CF20A587 H环丙基 HCF3CF3CF20A588 H(CH3)3C HCF3CF2CF20A589 H(CH3)2CH HCF3CF2CF20A590 HCH3(CH2)2HCF3CF2CF20A591 HCH3OCH2HCF3CF2CF20A592 HCH3O(CH2)2HCF3CF2CF20A593 HPh HCF3CF2CF20A594 HPhO HCF3CF2CF20A595 HPhS HCF3CF2CF20A596 HPhSO HCF3CF2CF20A597 HPhSO2HCF3CF2CF20A598 HCH3SHCF3CF2CF20A599 HCH3SO HCF3CF2CF20A600 HCF3HCF3CF2CF20A601 HF2CHHCF3CF2CF20化合物序号R2R3R4R5pA602 HHCC HCF3CF2CF20A603 HCH3CC HCF3CF2CF20A604 HCH2＝CHHCF3CF2CF20A605 HCH2＝CHCH2HCF3CF2CF20A606 HCH3SO2N(CH3) HCF3CF2CF20A607 H(CH3)2N HCF3CF2CF20A608 H(CH3)2NSO2HCF3CF2CF20A609 HCH3SCH2HCF3CF2CF20A610 HCH3SOCH2HCF3CF2CF20A611 HCH3SO2CH2HCF3CF2CF20A612 HCH3HCF2Cl 0A613 HCH3CH2HCF2Cl 0A614 H环丙基 HCF2Cl 0A615 H(CH3)3C HCF2Cl 0A616 H(CH3)2CH HCF2Cl 0A617 HCH3(CH2)2HCF2Cl 0A618 HCH3OCH2HCF2Cl 0A619 HCH3O(CH2)2HCF2Cl 0A620 HPh HCF2Cl 0A621 HPhO HCF2Cl 0A622 HPhS HCF2Cl 0A623 HPhSO HCF2Cl 0A624 HPhSO2HCF2Cl 0A625 HCH3S HCF2Cl 0A626 HCH3SO HCF2Cl 0A627 HCF3HCF2Cl 0A628 HF2CH HCF2Cl 0A629 HHCC HCF2Cl 0A630 HCH3CC HCF2Cl 0A631 HCH2＝CHHCF2Cl 0A632 HCH2＝CHCH2HCF2Cl 0A633 HCH3SO2N(CH3) HCF2Cl 0A634 H(CH3)2N HCF2Cl 0化合物序号R2R3R4R5pA635 H(CH3)2NSO2HCF2Cl 0A636 HCH3SCH2HCF2Cl 0A637 HCH3SOCH2HCF2Cl 0A638 HCH3SO2CH2HCF2Cl 0A639 HCH3HCHF20A640 HCH3CH2HCHF20A641 H环丙基 HCHF20A642 H(CH3)3C HCHF20A643 H(CH3)2CH HCHF20A644 HCH3(CH2)2HCHF20A645 HCH3OCH2HCHF20A646 HCH3O(CH2)2HCHF20A647 HPh HCHF20A648 HPhO HCHF20A649 HPhS HCHF20A650 HPhSOHCHF20A651 HPhSO2HCHF20A652 HCH3S HCHF20A653 HCH3SO HCHF20A654 HCF3HCHF20A655 HF2CH HCHF20A656 HHCC HCHF20A657 HCH3CC HCHF20A658 HCH2＝CHHCHF20A659 HCH2＝CHCH2HCHF20A660 HCH3SO2N(CH3) HCHF20A661 H(CH3)2N HCHF20A662 H(CH3)2NSO2HCHF20A663 HCH3SCH2HCHF20A664 HCH3SOCH2HCHF20A665 HCH3SO2CH2HCHF20A666 HCH3HCCl30A667 HCH3CH2HCCl30化合物序号R2R3R4R5pA668 H环丙基 HCCl30A669 H(CH3)3C HCCl30A670 H(CH3)2CHHCCl30A671 HCH3(CH2)2HCCl30A672 HCH3OCH2HCCl30A673 HCH3O(CH2)2HCCl30A674 HPh HCCl30A675 HPhOHCCl30A676 HPhSHCCl30A677 HPhSO HCCl30A678 HPhSO2HCCl30A679 HCH3S HCCl30A680 HCH3SO HCCl30A681 HCF3HCCl30A682 HF2CH HCCl30A683 HHCCHCCl30A684 HCH3CC HCCl30A685 HCH2＝CH HCCl30A686 HCH2＝CHCH2HCCl30A687 HCH3SO2N(CH3)HCCl30A688 H(CH3)2N HCCl30A689 H(CH3)2NSO2HCCl30A690 HCH3SCH2HCCl30A691 HCH3SOCH2HCCl30A692 HCH3SO2CH2HCCl30A693 HCH3CH3CF30A694 HCH3CH2CH3CF30A695 H环丙基 CH3CF30A696 H(CH3)3C CH3CF30A697 H(CH3)2CH CH3CF30A698 HCH3(CH2)2CH3CF30A699 HCH3OCH2CH3CF30A700 HCH3O(CH2)2CH3CF30化合物序号R2R3R4R5pA701 HPh CH3CF30A702 HPhO CH3CF30A703 HPhS CH3CF30A704 HPhSOCH3CF30A705 HPhSO2CH3CF30A706 HCH3S CH3CF30A707 HCH3SO CH3CF30A708 HCF3CH3CF30A709 HF2CH CH3CF30A710 HHCC CH3CF30A711 HCH3CC CH3CF30A712 HCH2＝CHCH3CF30A713 HCH2＝CHCH2CH3CF30A714 HCH3SO2N(CH3) CH3CF30A715 H(CH3)2N CH3CF30A716 H(CH3)2NSO2CH3CF30A717 HCH3SCH2CH3CF30A718 HCH3SOCH2CH3CF30A719 HCH3SO2CH2CH3CF30A720 HCH3CH3CF3CF20A721 HCH3CH2CH3CF3CF20A722 H环丙基 CH3CF3CF20A723 H(CH3)3C CH3CF3CF20A724 H(CH3)2CH CH3CF3CF20A725 HCH3(CH2)2CH3CF3CF20A726 HCH3OCH2CH3CF3CF20A727 HCH3O(CH2)2CH3CF3CF20A728 HPh CH3CF3CF20A729 HPhO CH3CF3CF20A730 HPhS CH3CF3CF20A731 HPhSO CH3CF3CF20A732 HPhSO2CH3CF3CF20A733 HCH3SCH3CF3CF20化合物序号R2R3R4R5pA734 H CH3SO CH3CF3CF20A735 H CF3CH3CF3CF20A736 H F2CH CH3CF3CF20A737 H HCC CH3CF3CF20A738 H CH3CC CH3CF3CF20A739 H CH2＝CHCH3CF3CF20A740 H CH2＝CHCH2CH3CF3CF20A741 H CH3SO2N(CH3)CH3CF3CF20A742 H (CH3)2N CH3CF3CF20A743 H (CH3)2NSO2CH3CF3CF20A744 H CH3SCH2CH3CF3CF20A745 H CH3SOCH2CH3CF3CF20A746 H CH3SO2CH2CH3CF3CF20A747 H CH3CH3CF3CF2CF20A748 H CH3CH2CH3CF3CF2CF20A749 H 环丙基 CH3CF3CF2CF20A750 H (CH3)3C CH3CF3CF2CF20A751 H (CH3)2CH CH3CF3CF2CF20A752 H CH3(CH2)2CH3CF3CF2CF20A753 H CH3OCH2CH3CF3CF2CF20A754 H CH3O(CH2)2CH3CF3CF2CF20A755 H Ph CH3CF3CF2CF20A756 H PhO CH3CF3CF2CF20A757 H PhS CH3CF3CF2CF20A758 H PhSOCH3CF3CF2CF20A759 H PhSO2CH3CF3CF2CF20A760 H CH3S CH3CF3CF2CF20A761 H CH3SO CH3CF3CF2CF20A762 H CF3CH3CF3CF2CF20A763 H F2CH CH3CF3CF2CF20A764 H HCC CH3CF3CF2CF20A765 H CH3CC CH3CF3CF2CF20A766 H CH2＝CHCH3CF3CF2CF20化合物序号R2R3R4R5pA767 HCH2＝CHCH2CH3CF3CF2CF20A768 HCH3SO2N(CH3)CH3CF3CF2CF20A769 H(CH3)2N CH3CF3CF2CF20A770 H(CH3)2NSO2CH3CF3CF2CF20A771 HCH3SCH2CH3CF3CF2CF20A772 HCH3SOCH2CH3CF3CF2CF20A773 HCH3SO2CH2CH3CF3CF2CF20A774 HCH3CH3CF2Cl 0A775 HCH3CH2CH3CF2Cl 0A776 H环丙基 CH3CF2Cl 0A777 H(CH3)3C CH3CF2Cl 0A778 H(CH3)2CH CH3CF2Cl 0A779 HCH3(CH2)2CH3CF2Cl 0A780 HCH3OCH2CH3CF2Cl 0A781 HCH3O(CH2)2CH3CF2Cl 0A782 HPh CH3CF2Cl 0A783 HPhO CH3CF2Cl 0A784 HPhS CH3CF2Cl 0A785 HPhSOCH3CF2Cl 0A786 HPhSO2CH3CF2Cl 0A787 HCH3S CH3CF2Cl 0A788 HCH3SO CH3CF2Cl 0A789 HCF3CH3CF2Cl 0A790 HF2CH CH3CF2Cl 0A791 HHCC CH3CF2Cl 0A792 HCH3CC CH3CF2Cl 0A793 HCH2＝CHCH3CF2Cl 0A794 HCH2＝CHCH2CH3CF2Cl 0A795 HCH3SO2N(CH3) CH3CF2Cl 0A796 H(CH3)2N CH3CF2Cl 0A797 H(CH3)2NSO2CH3CF2Cl 0A798 HCH3SCH2CH3CF2Cl 0A799 HCH3SOCH2CH3CF2Cl 0化合物序号R2R3R4R5pA800 HCH3SO2CH2CH3CF2Cl 0A801 HCH3CH3CHF20A802 HCH3CH2CH3CHF20A803 H环丙基 CH3CHF20A804 H(CH3)3C CH3CHF20A805 H(CH3)2CH CH3CHF20A806 HCH3(CH2)2CH3CHF20A807 HCH3OCH2CH3CHF20A808 HCH3O(CH2)2CH3CHF20A809 HPh CH3CHF20A810 HPhO CH3CHF20A811 HPhS CH3CHF20A812 HPhSOCH3CHF20A813 HPhSO2CH3CHF20A814 HCH3S CH3CHF20A815 HCH3SO CH3CHF20A816 HCF3CH3CHF20A817 HF2CH CH3CHF20A818 HHCC CH3CHF20A819 HCH3CC CH3CHF20A820 HCH2＝CHCH3CHF20A821 HCH2＝CHCH2CH3CHF20A822 HCH3SO2N(CH3) CH3CHF20A823 H(CH3)2N CH3CHF20A824 H(CH3)2NSO2CH3CHF20A825 HCH3SCH2CH3CHF20A826 HCH3SOCH2CH3CHF20A827 HCH3SO2CH2CH3CHF20A828 HCH3CH3CCl30A829 HCH3CH2CH3CCl30A830 H环丙基 CH3CCl30A831 H(CH3)3C CH3CCl30A832 H(CH3)2CH CH3CCl30化合物序号R2R3R4R5pA833 HCH3(CH2)2CH3CCl30A834 HCH3OCH2CH3CCl30A835 HCH3O(CH2)2CH3CCl30A836 HPh CH3CCl30A837 HPhO CH3CCl30A838 HPhS CH3CCl30A839 HPhSOCH3CCl30A840 HPhSO2CH3CCl30A841 HCH3S CH3CCl30A842 HCH3SO CH3CCl30A843 HCF3CH3CCl30A844 HF2CH CH3CCl30A845 HHCC CH3CCl30A846 HCH3CC CH3CCl30A847 HCH2＝CHCH3CCl30A848 HCH2＝CHCH2CH3CCl30A849 HCH3SO2N(CH3) CH3CCl30A850 H(CH3)2N CH3CCl30A851 H(CH3)2NSO2CH3CCl30A852 HCH3SCH2CH3CCl30A853 HCH3SOCH2CH3CCl30A854 HCH3SO2CH2CH3CCl30A855 HCH3Ph CF30A856 HCH3CH2Ph CF30A857 H(CH3)2CH Ph CF30A858 H(CH3)2CH Ph CF30A859 H环丙基 Ph CF30A860 HCH3(CH2)2Ph CF30A861 HCH3OCH2Ph CF30A862 HCH3O(CH2)2Ph CF30A863 HPh Ph CF30A864 HPhO Ph CF30A865 HPhS Ph CF30化合物序号R2R3R4R5pA866 HPhSOPhCF30A867 HPhSO2PhCF30A868 HCH3S PhCF30A869 HCH3SO PhCF30A870 HCF3PhCF30A871 HF2CH PhCF30A872 HHCC PhCF30A873 HCH3CC PhCF30A874 HCH2＝CHPhCF30A875 HCH2＝CHCH2PhCF30A876 HCH3SO2N(CH3) PhCF30A877 H(CH3)2N PhCF30A878 H(CH3)2NSO2PhCF30A879 HCH3SCH2PhCF30A880 HCH3SOCH2PhCF30A881 HCH3SO2CH2PhCF30A882 HCH3PhCF3CF20A883 HCH3CH2PhCF3CF20A884 H环丙基 PhCF3CF20A885 H(CH3)3C PhCF3CF20A886 H(CH3)2CH PhCF3CF20A887 HCH3(CH2)2PhCF3CF20A888 HCH3OCH2PhCF3CF20A889 HCH3O(CH2)2PhCF3CF20A890 HPh PhCF3CF20A891 HPhO PhCF3CF20A892 HPhS PhCF3CF20A893 HPhSO PhCF3CF20A894 HPhSO2PhCF3CF20A895 HCH3SPhCF3CF20A896 HCH3SO PhCF3CF20A897 HCF3PhCF3CF30A898 HF2CHPhCF3CF20化合物序号R2R3R4R5pA899 HHCC PhCF3CF20A900 HCH3CC PhCF3CF20A901 HCH2＝CHPhCF3CF20A902 HCH2＝CHCH2PhCF3CF20A903 HCH3SO2N(CH3) PhCF3CF20A904 H(CH3)2N PhCF3CF20A905 H(CH3)2NSO2PhCF3CF20A906 HCH3SCH2PhCF3CF20A907 HCH3SOCH2PhCF3CF20A908 HCH3SO2CH2PhCF3CF20A909 HCH3PhCF3CF2CF20A910 HCH3CH2PhCF3CF2CF20A911 H环丙基 PhCF3CF2CF20A912 H(CH3)3C PhCF3CF2CF20A913 H(CH3)2CH PhCF3CF2CF20A914 HCH3(CH2)2PhCF3CF2CF20A915 HCH3OCH2PhCF3CF2CF20A916 HCH3O(CH2)2PhCF3CF2CF20A917 HPh PhCF3CF2CF20A918 HPhO PhCF3CF2CF20A919 HPhS PhCF3CF2CF20A920 HPhSOPhCF3CF2CF20A921 HPhSO2PhCF3CF2CF20A922 HCH3S PhCF3CF2CF20A923 HCH3SO PhCF3CF2CF20A924 HCF3PhCF3CF2CF20A925 HF2CH PhCF3CF2CF20A926 HHCC PhCF3CF2CF20A927 HCH3CC PhCF3CF2CF20A928 HCH2＝CHPhCF3CF2CF20A929 HCH2＝CHCH2PhCF3CF2CF20A930 HCH3SO2N(CH3) PhCF3CF2CF20A931 H(CH3)2N PhCF3CF2CF20化合物序号R2R3R4R5pA932 H(CH3)2NSO2PhCF3CF2CF20A933 HCH3SCH2PhCF3CF2CF20A934 HCH3SOCH2PhCF3CF2CF20A935 HCH3SO2CH2PhCF3CF2CF20A936 HCH3PhCF2Cl0A937 HCH3CH2PhCF2Cl0A938 H环丙基 PhCF2Cl0A939 H(CH3)3C PhCF2Cl0A940 H(CH3)2CH PhCF2Cl0A941 HCH3(CH2)2PhCF2Cl0A942 HCH3OCH2PhCF2Cl0A943 HCH3O(CH2)2PhCF2Cl0A944 HPh PhCF2Cl0A945 HPhO PhCF2Cl0A946 HPhS PhCF2Cl0A947 HPhSOPhCF2Cl0A948 HPhSO2PhCF2Cl0A949 HCH3S PhCF2Cl0A950 HCH3SO PhCF2Cl0A951 HCF3PhCF2Cl0A952 HF2CH PhCF2Cl0A953 HHCC PhCF2Cl0A954 HCH3CC PhCF2Cl0A955 HCH2＝CHPhCF2Cl0A956 HCH2＝CHCH2PhCF2Cl0A957 HCH3SO2N(CH3) PhCF2Cl0A958 H(CH3)2N PhCF2Cl0A959 H(CH3)2NSO2PhCF2Cl0A960 HCH3SCH2PhCF2Cl0A961 HCH3SOCH2PhCF2Cl0A962 HCH3SO2CH2PhCF2Cl0A963 HCH3PhCHF20A964 HCH3CH2PhCHF20化合物序号 R2R3R4R5pA965 H(CH3)3C PhCHF20A966 H(CH3)2CH PhCHF20A967 H环丙基 PhCHF20A968 HCH3(CH2)2PhCHF20A969 HCH3OCH2PhCHF20A970 HCH3O(CH2)2PhCHF20A971 HPh PhCHF20A972 HPhO PhCHF20A973 HPhS PhCHF20A974 HPhSOPhCHF20A975 HPhSO2PhCHF20A976 HCH3S PhCHF20A977 HCH3SO PhCHF20A978 HCF3PhCHF20A979 HF2CH PhCHF20A980 HHCC PhCHF20A981 HCH3CC PhCHF20A982 HCH2＝CHPhCHF20A983 HCH2＝CHCH2PhCHF20A984 HCH3SO2N(CH3) PhCHF20A985 H(CH3)2N PhCHF20A986 H(CH3)2NSO2PhCHF20A987 HCH3SCH2PhCHF20A988 HCH3SOCH2PhCHF20A989 HCH3SO2CH2PhCHF20A990 HCH3PhCCl30A991 HCH3CH2PhCCl30A992 H(CH3)3C PhCCl30A993 H(CH3)2CH PhCCl30A994 H环丙基 PhCCl30A995 HCH3(CH2)2PhCCl30A996 HCH3OCH2PhCCl30A997 HCH3O(CH2)2PhCCl30化合物序号R2R3R4R5pA998 H Ph PhCCl30A999 H PhO PhCCl30A1000 H PhS PhCCl30A1001 H PhSOPhCCl30A1002 H PhSO2PhCCl30A1003 H CH3S PhCCl30A1004 H CH3SO PhCCl30A1005 H CF3PhCCl30A1006 H F2CH PhCCl30A1007 H HCC PhCCl30A1008 H CH3CC PhCCl30A1009 H CH2＝CHPhCCl30A1010 H CH2＝CHCH2PhCCl30A1011 H CH3SO2N(CH3) PhCCl30A1012 H (CH3)2N PhCCl30A1013 H (CH3)2NSO2PhCCl30A1014 H CH3SCH2PhCCl30A1015 H CH3SOCH2PhCCl30A1016 H CH3SO2CH2PhCCl30A1017 FH H CF30A1018 Cl H H CF30A1019 Br H H CF30A1020 NC H H CF30A1021 CH3SO2O H H CF30A1022 CH3O H H CF30A1023 CH3CH2O H H CF30A1024 CH2CH＝CH2O H H CF30A1025 HCCCH2OH H CF30A1026 PhCH2S H H CF30A1027 PhCH2SO2H H CF30A1028 ClCH2CH2H H CF30A1029 BrCH2H H CF30A1030 FCH2H H CF30化合物序号 R2R3R4R5pA1031CHF2CH2H HCF30A1032CF3CH2H HCF30A1033[1，3]-咪唑-1-基甲基H HCF30A1034CHCl2CH2H HCF30A1035ClCH＝CHH HCF30A1036Cl2C＝CH H HCF30A1037CF3CH＝CH H HCF30A1038ClCCH HCF30A1039PhCH2H HCF30A1040CH3CH2CH3HCF30A1041CH3OHHCF30A1042CH3F HCF30A1043CH3ClHCF30A1044F CH3HCF30A1045Cl CH3HCF30A1046H F HCF30A1047H ClHCF30A1048H BrHCF30A1049H OHHCF30A1050H OCH3HCF30A1051H OCHF2HCF30A1052H OSO2CH3HCF30A1053H OSO2CF3HCF30A1054H ClCH2HCF30A1055H BrCH2HCF30A1056H FCH2HCF30A1057H CHF2CH2HCF30A1058H CF3CH2HCF30A1059H 三唑基甲基HCF30A1060H CHCl2CH2HCF30A1061H ClCH＝CH HCF30A1062H Cl2C＝CH HCF30A1063H CF3CH＝CHHCF30化合物序号 R2R3R4R5pA1064HClCC H CF30A1065HCH3C(O) H CF30A1066HPh H CF30A1067HSO2CH3H CF30A1068HSO2CF3H CF30A1069HNC H CF30A1070HNO2H CF30A1071CH3H F CF30A1072CH3H ClCF30A1073CH3H BrCF30A1074CH3H NCCF30A1075CH3H CH3O CF30A1076CH3H CH3S CF30A1077CH3H CH3SOCF30A1078CH3H CH3SO2CF30A1079CH3CH2OCH2H H CF30A1080PhOCH2H H CF30A1081 H H CF30A1082(CH3)2CH2OCH2H H CF30A1083BrCH2CH2H H CF30A1084FCH2CH2H H CF30A1085 H H CF30A1086 H H CF30A1087 H H CF30A1088 H H CF30化合物序号R2R3R4R5pA1089HHCF30A1090HHCF30A1091环丙基-CH2HHCF30A10922，2-二氯环丙-1-基HHCF30A1093CH3OC(O)CH＝CH HHCF30A1094CH3CH2OC(O)CH＝CH HHCF30A1095ClCH2CH＝CH HHCF30A1096CH＝C＝CH HHCF30A1097(CH3)2NCH2HHCF30A1098HOCH2HHCF30A1099CH3C(O)OCH2HHCF30A1100PhC(O)OCH2HHCF30A1101PhCH2CH2HHCF30A1102CH3OC(O)CH2HHCF30A1103NCCH2HHCF30A1104CH3(CH2)7SCH2HHCF30A1105CH3(CH2)7SOCH2HHCF30A1106CH3(CH2)7SO2CH2HHCF30A1107HHCF30A1108ClCH2CC HHCF30A1109CHF2CH2CH2HHCF30A1110CHCl2CH2CH2HHCF30A1111CF3SO2O HHCF30A1112HHCF30A1113HHCF30化合物序号 R2R3R4R5pA1114HHCF30A1115 HHCF30A1116 HHCF30A1117 HHCF30A1118CH3ON＝CHCH2HHCF30A1119O＝CHCH2HHCF30A1120CH3CH2OCH2HHCF2Cl0A1121PhOCH2HHCF2Cl0A1122 HHCF2Cl0A1123(CH3)2CH2OCH2HHCF2Cl0A1124BrCH2HHCF2Cl0A1125FCH2HHCF2Cl0A1126HHCF2Cl0A1127 HHCF2Cl0A1128 HHCF2Cl0A1129 HHCF2Cl0A1130 HHCF2Cl0A1131HHCF2Cl 0A1132环丙基-CH2HHCF2Cl 0A11332，2-二氯环丙-1-基HHCF2Cl 0化合物序号R2R3R4R5pA1134CH3OC(O)CH＝CH HHCF2Cl0A1135CH3CH2OC(O)CH＝CH HHCF2Cl0A1136ClCH2CH＝CH HHCF2Cl0A1137CH＝C＝CHHHCF2Cl0A1138(CH3)2NCH2HHCF2Cl0A1139HOCH2HHCF2Cl0A1140CH3C(O)OCH2HHCF2Cl0A1141PhC(O)OCH2HHCF2Cl0A1142PhCH2HHCF2Cl0A1143CH3OC(O)CH2HHCF2Cl0A1144NCCH2HHCF2Cl0A1145CH3(CH2)7SCH2HHCF2Cl0A1146CH3(CH2)7SOCH2HHCF2Cl0A1147CH3(CH2)7SO2CH2HHCF2Cl0A1148 HHCF2Cl0A1149ClCH2CC HHCF2Cl0A1150Br HHCF2Cl0A1151Cl HHCF2Cl0A1152CF3SO2O HHCF2Cl0A1153 HHCF2Cl0A1154 HHCF2Cl0A1155 HHCF2Cl0A1156HHCF2Cl0A1157HHCF2Cl0A1158HHCF2Cl0A1159CH3ON＝CHCH2HHCF2Cl0化合物序号R2R3R4R5pA1160 O＝CHCH2HHCF2Cl 0A1161 CH3CH2OCH2HHCF2H0A1162 PhOCH2HHCF2H0A1163 HHCF2H0A1164 (CH3)2CH2OCH2HHCF2H0A1165 BrCH2HHCF2H0A1166 FCH2HHCF2H0A1167HHCF2H0A1168 HHCF2H0A1169 HHCF2H0A1170 HHCF2H0A1171 HHCF2H0A1172 HHCF2H0A1173 环丙基-CH2HHCF2H0A1174 2，2-二氯环丙-1-基HHCF2H0A1175 CH3OC(O)CH＝CH HHCF2H0A1176 CH3CH2OC(O)CH＝CH HHCF2H0A1177 ClCH2CH＝CH HHCF2H0A1178 CH＝C＝CH HHCF2H0A1179 (CH3)2NCH2HHCF2H0A1180 HOCH2HHCF2H0A1181 CH3C(O)OCH2HHCF2H0A1182 PhC(O)OCH2HHCF2H0化合物序号R2R3R4R5pA1183 PhCH2HHCF2H0A1184 CH3OC(O)CH2HHCF2H0A1185 NCCH2HHCF2H0A1186 CH3(CH2)7SCH2HHCF2H0A1187 CH3(CH2)7SOCH2HHCF2H0A1188 CH3(CH2)7SO2CH2HHCF2H0A1189HHCF2H0A1190 ClCH2CC HHCF2H0A1191 BrHHCF2H0A1192 ClHHCF2H0A1193 CF3SO2OHHCF2H0A1194HHCF2H0A1195HHCF2H0A1196HHCF2H0A1197 HHCF2H0A1198 HHCF2H0A1199 HHCF2H0A1200 CH3ON＝CHCH2HHCF2H0A1201 O＝CHCH2HHCF2H0A1202 CH3CH＝CHHHCF30A1203 CH3SO2NHHHCF30A1204 CH3CH2CH2OHCH3CF30A1205 ClCH3HCF30A1206 F2CHOHHCF30A1207 CH3CH2C(O)OCH2HHCF30A1208 CH3CH2OC(O)OCH2HHCF30化合物序号R2R3R4R5pA1209 CH3OCH2OCH2HHCF30A1210 CH3HHCF31A1211 CH3CH2HHCF31A1212 环丙基HHCF31A1213 CH3(CH2)2HHCF31A1214 CH3OCH2HHCF31A1215 CF3HHCF31A1216 F2CH HHCF31A1217 ClCH2HHCF31A1218 CH3SO2CH2HHCF31A1219 CH3CF3HCH31A1220 CH3CH2OCH2HHCF31A1221 PhOCH2HHCF31A1222 (CH3)2CH2OCH2HHCF31A1223 BrCH2HHCF31A1224 FCH2HHCF31A1225HHCF31A1226 HHCF31A1227 环丙基-CH2HHCF31A1228 2，2-二氯环丙-1-基 HHCF31A1229 (CH3)2NCH2HHCF31A1230 HOCH2HHCF31A1231 CH3C(O)OCH2HHCF31A1232 PhC(O)OCH2HHCF31A1233 PhCH2HHCF31A1234 CH3OC(O)CH2HHCF31A1235 NCCH2HHCF31A1236 CH3(CH2)7SO2CH2HHCF31A1237 Br HHCF31化合物序号R2R3R4R5pA1238 ClHHCF31A1239 O＝CHCH2HHCF31A1240 CH3HHCF2Cl1A1241 CH3CH2HHCF2Cl1A1242 环丙基HHCF2Cl1A1243 CH3(CH2)2HHCF2Cl1A1244 CH3OCH2HHCF2Cl1A1245 CF3HHCF2Cl1A1246 F2CH HHCF2Cl1A1247 ClCH2HHCF2Cl1A1248 CH3SO2CH2HHCF2Cl1A1249 CH3CF3HCF2Cl1A1250 CH3CH2OCH2HHCF2Cl1A1251 PhOCH2HHCF2Cl1A1252 (CH3)2CH2OCH2HHCF2Cl1A1253 BrCH2HHCF2Cl1A1254 FCH2HHCF2Cl1A1255 HHCF2Cl1A1256 HHCF2Cl1A1257 环丙基-CH2HHCF2Cl1A1258 2，2-二氯环丙-1-基HHCF2Cl1A1259 (CH3)2NCH2HHCF2Cl1A1260 HOCH2HHCF2Cl1A1261 CH3C(O)OCH2HHCF2Cl1A1262 PhC(O)OCH2HHCF2Cl1A1263 PhCH2HHCF2Cl1A1264 CH3OC(O)CH2HHCF2Cl1A1265 NCCH2HHCF2Cl1A1266 CH3(CH2)7SO2CH2HHCF2Cl1化合物序号R2R3R4R5pA1267 Br HHCF2Cl 1A1268 Cl HHCF2Cl 1A1269 O＝CHCH2HHCF2Cl 1A1270 CH3HHCF2H1A1271 CH3CH2HHCF2H1A1272 环丙基 HHCF2H1A1273 CH3(CH2)2HHCF2H1A1274 CH3OCH2HHCF2H1A1275 CF3HHCF2H1A1276 F2CH HHCF2H1A1277 ClCH2HHCF2H1A1278 CH3SO2CH2HHCF2H1A1279 CH3CF3HCF2H1A1280 CH3CH2OCH2HHCF2H1A1281 PhOCH2HHCF2H1A1282 (CH3)2CH2OCH2HHCF2H1A1283 BrCH2HHCF2H1A1284 FCH2HHCF2H1A1285HHCF2H1A1286 HHCF2H1A1287 环丙基-CH2HHCF2H1A1288 2，2-二氯环丙-1-基 HHCF2H1A1289 (CH3)2NCH2HHCF2H1A1290 HOCH2HHCF2H1A1291 CH3C(O)OCH2HHCF2H1A1292 PhC(O)OCH2HHCF2H1A1293 PhCH2HHCF2H1A1294 CH3OC(O)CH2HHCF2H1A1295 NCCH2HHCF2H1化合物序号R2R3R4R5pA1296 CH3(CH2)7SO2CH2HH CF2H1A1297 BrHH CF2H1A1298 ClHH CF2H1A1299 O＝CHCH2HH CF2H1A1300 CH3HH CF3CF21A1301 HOHPh CF30A1302 CH3HCH2＝CHCF30A1303 CH3HCH3CH2O CF30A1304 HOCH3H CF30A1305 HOHH CF30A1306 (CH3CH2)2N(O)CO HH CF30A1307 CH3H甲苯磺酰基-OCF30A1308 CH3HCH3CC CF30A1309 CH3HHCC CF30A1310 CH3HClCH2CCCF30A1311 CH3HPhCH2O CF30A1312 CH3HCF3SO2O CF30A1313 CH3H(CH3)2N CF30A1314 CH3HCH3C(O)O CF30A1315 CH3HCH3CH2C(O)O CF30A1316 CH3HPhC(O)O CF30A1317 CH3H3-吡啶基CF30A1318 CH3OCH2OCH2HH CF2Cl 0A1319 CH3OCH2OCH2HH CF2H0A1320 CH3OCH2OCH2HH CF2CF30A1321 CH3OCH2OCH2HH CF31A1322 CH3O HCH3CF30下表2中，Q为Q1 并且Q1代表下列基团B表2基团B；基团R6R7R8R9R10WB1 HHHHOHCH2B2 CH3HHHOHCH2B3 CH3CH2HHHOHCH2B4 CH3CH2CH2HHHOHCH2B5 (CH3)2CH HHHOHCH2B6 (CH3)3CHHHOHCH2B7 CH3SHHHOHCH2B8 CH3SO HHHOHCH2B9 CH3SO2HHHOHCH2B10 Ph HHHOHCH2B11 CH3OHHHOHCH2B12 CH3OC(O)HHHOHCH2B13 CH3CH2OC(O)HHHOHCH2B14 CH2＝CHCH2HHHOHCH2B15 HCCCH2HHHOHCH2B16 CF3HHHOHCH2B17 (CH3)2NSO2HHHOHCH2B18 (CH3)2NHHHOHCH2B19 PhO HHHOHCH2B20 PhS HHHOHCH2B21 PhSO HHHOHCH2B22 PhSO2HHHOHCH2基团 R6R7R8R9R10WB23CN H HHOHCH2B24CH3CH3HHOHCH2B25CH3CH2CH3HHOHCH2B26CH3CH2CH2CH3HHOHCH2B27(CH3)2CH CH3HHOHCH2B28(CH3)3C CH3HHOHCH2B29CH3S CH3HHOHCH2B30CH3SO CH3HHOHCH2B31CH3SO2CH3HHOHCH2B32Ph CH3HHOHCH2B33CH3O CH3HHOHCH2B34CH3OC(O) CH3HHOHCH2B35CH3CH2OC(O) CH3HHOHCH2B36CH2＝CHCH2CH3HHOHCH2B37HCCCH2CH3HHOHCH2B38CF3CH3HHOHCH2B39(CH3)2NSO2CH3HHOHCH2B40(CH3)2N CH3HHOHCH2B41PhOCH3HHOHCH2B42PhSCH3HHOHCH2B43PhSO CH3HHOHCH2B44PhSO2CH3HHOHCH2B45CN CH3HHOHCH2B46CH3H CH3HOHCH2B47CH3CH2H CH3HOHCH2B48CH3CH2CH2H CH3HOHCH2B49(CH3)2CH H CH3HOHCH2B50(CH3)3C H CH3HOHCH2B51CH3S H CH3HOHCH2B52CH3SO H CH3HOHCH2B53CH3SO2H CH3HOHCH2B54Ph H CH3HOHCH2B55CH3O H CH3HOHCH2基团R6R7R8R9R10WB56CH3OC(O)H CH3HOHCH2B57CH3CH2OC(O)H CH3HOHCH2B58CH2＝CHCH2H CH3HOHCH2B59HCCCH2H CH3HOHCH2B60CF3H CH3HOHCH2B61(CH3)2NSO2H CH3HOHCH2B62(CH3)2NH CH3HOHCH2B63PhO H CH3HOHCH2B64PhS H CH3HOHCH2B65PhSO H CH3HOHCH2B66PhSO2H CH3HOHCH2B67CNH CH3HOHCH2B68CH3CH3CH3HOHCH2B69CH3CH2CH3CH3HOHCH2B70CH3CH2CH2CH3CH3HOHCH2B71(CH3)2CH CH3CH3HOHCH2B72(CH3)3CCH3CH3HOHCH2B73CH3SCH3CH3HOHCH2B74CH3SO CH3CH3HOHCH2B75CH3SO2CH3CH3HOHCH2B76Ph CH3CH3HOHCH2B77CH3OCH3CH3HOHCH2B78CH3OC(O)CH3CH3HOHCH2B79CH3CH2OC(O)CH3CH3HOHCH2B80CH2＝CHCH2CH3CH3HOHCH2B81HCCCH2CH3CH3HOHCH2B82CF3CH3CH3HOHCH2B83(CH3)2NSO2CH3CH3HOHCH2B84(CH3)2NCH3CH3HOHCH2B85PhO CH3CH3HOHCH2B86PhS CH3CH3HOHCH2B87PhSO CH3CH3HOHCH2B88PhSO2CH3CH3HOHCH2基团R6R7R8R9R10WB89 CN CH3CH3H OHCH2B90 CH3CH3CH3CH3OHCH2B91 CH3CH2CH3CH3CH3OHCH2B92 CH3CH2CH2CH3CH3CH3OHCH2B93 (CH3)2CH CH3CH3CH3OHCH2B94 (CH3)3C CH3CH3CH3OHCH2B95 CH3S CH3CH3CH3OHCH2B96 CH3SO CH3CH3CH3OHCH2B97 CH3SO2CH3CH3CH3OHCH2B98 Ph CH3CH3CH3OHCH2B99 CH3O CH3CH3CH3OHCH2B100CH3OC(O) CH3CH3CH3OHCH2B101CH3CH2OC(O) CH3CH3CH3OHCH2B102CH2＝CHCH2CH3CH3CH3OHCH2B103HCCCH2CH3CH3CH3OHCH2B104CF3CH3CH3CH3OHCH2B105(CH3)2NSO2CH3CH3CH3OHCH2B106(CH3)2N CH3CH3CH3OHCH2B107PhO CH3CH3CH3OHCH2B108PhS CH3CH3CH3OHCH2B109PhSO CH3CH3CH3OHCH2B110PhSO2CH3CH3CH3OHCH2B111CN CH3CH3CH3OHCH2B112CH3CH2CH3CH2H H OHCH2B113CH3CH2CH2CH3CH2H H OHCH2B114(CH3)2CHCH3CH2H H OHCH2B115(CH3)3C CH3CH2H H OHCH2B116CH3S CH3CH2H H OHCH2B117CH3SOCH3CH2H H OHCH2B118CH3SO2CH3CH2H H OHCH2B119PhCH3CH2H H OHCH2B120CH3O CH3CH2H H OHCH2B121CH3OC(O) CH3CH2H H OHCH2基团R6R7R8R9R10WB122CH3CH2OC(O) CH3CH2HHOHCH2B123CH2＝CHCH2CH3CH2HHOHCH2B124HCCCH2CH3CH2HHOHCH2B125CF3CH3CH2HHOHCH2B126(CH3)2NSO2CH3CH2HHOHCH2B127(CH3)2N CH3CH2HHOHCH2B128PhOCH3CH2HHOHCH2B129PhSCH3CH2HHOHCH2B130PhSO CH3CH2HHOHCH2B131PhSO2CH3CH2HHOHCH2B132CN CH3CH2HHOHCH2B133H HHHOHCHCH3B134CH3HHHOHCHCH3B135CH3CH2HHHOHCHCH3B136CH3CH2CH2HHHOHCHCH3B137(CH3)2CH HHHOHCHCH3B138(CH3)3C HHHOHCHCH3B139CH3S HHHOHCHCH3B140CH3SO HHHOHCHCH3B141CH3SO2HHHOHCHCH3B142Ph HHHOHCHCH3B143CH3O HHHOHCHCH3B144CH3OC(O) HHHOHCHCH3B145CH3CH2OC(O) HHHOHCHCH3B146CH2＝CHCH2HHHOHCHCH3B147HCCCH2HHHOHCHCH3B148CF3HHHOHCHCH3B149(CH3)2NSO2HHHOHCHCH3B150(CH3)2N HHHOHCHCH3B151PhOHHHOHCHCH3B152PhSHHHOHCHCH3B153PhSO HHHOHCHCH3B154PhSO2HHHOHCHCH3基团R6R7R8R9R10WB155CN H HHOHCHCH3B156CH3CH3HHOHCHCH3B157CH3CH2CH3HHOHCHCH3B158CH3CH2CH2CH3HHOHCHCH3B159(CH3)2CH CH3HHOHCHCH3B160(CH3)3C CH3HHOHCHCH3B161CH3S CH3HHOHCHCH3B162CH3SO CH3HHOHCHCH3B163CH3SO2CH3HHOHCHCH3B164Ph CH3HHOHCHCH3B165CH3O CH3HHOHCHCH3B166CH3OC(O) CH3HHOHCHCH3B167CH3CH2OC(O) CH3HHOHCHCH3B168CH2＝CHCH2CH3HHOHCHCH3B169HCCCH2CH3HHOHCHCH3B170CF3CH3HHOHCHCH3B171(CH3)2NSO2CH3HHOHCHCH3B172(CH3)2N CH3HHOHCHCH3B173PhO CH3HHOHCHCH3B174PhS CH3HHOHCHCH3B175PhSOCH3HHOHCHCH3B176PhSO2CH3HHOHCHCH3B177CN CH3HHOHCHCH3B178CH3H CH3HOHCHCH3B179CH3CH2H CH3HOHCHCH3B180CH3CH2CH2H CH3HOHCHCH3B181(CH3)2CH H CH3HOHCHCH3B182(CH3)3C H CH3HOHCHCH3B183CH3S H CH3HOHCHCH3B184CH3SO H CH3HOHCHCH3B185CH3SO2H CH3HOHCHCH3B186Ph H CH3HOHCHCH3B187CH3O H CH3HOHCHCH3基团R6R7R8R9R10WB188CH3OC(O) H CH3HOHCHCH3B189CH3CH2OC(O) H CH3HOHCHCH3B190CH2＝CHCH2H CH3HOHCHCH3B191HCCCH2H CH3HOHCHCH3B192CF3H CH3HOHCHCH3B193(CH3)2NSO2H CH3HOHCHCH3B194(CH3)2N H CH3HOHCHCH3B195PhOH CH3HOHCHCH3B196PhSH CH3HOHCHCH3B197PhSO H CH3HOHCHCH3B198PhSO2H CH3HOHCHCH3B199CN H CH3HOHCHCH3B200CH3CH3CH3HOHCHCH3B201CH3CH2CH3CH3HOHCHCH3B202CH3CH2CH2CH3CH3HOHCHCH3B203(CH3)2CH CH3CH3HOHCHCH3B204(CH3)3C CH3CH3HOHCHCH3B205CH3S CH3CH3HOHCHCH3B206CH3SO CH3CH3HOHCHCH3B207CH3SO2CH3CH3HOHCHCH3B208Ph CH3CH3HOHCHCH3B209CH3O CH3CH3HOHCHCH3B210CH3OC(O) CH3CH3HOHCHCH3B211CH3CH2OC(O) CH3CH3HOHCHCH3B212CH2＝CHCH2CH3CH3HOHCHCH3B213HCCCH2CH3CH3HOHCHCH3B214CF3CH3CH3HOHCHCH3B215(CH3)2NSO2CH3CH3HOHCHCH3B216(CH3)2N CH3CH3HOHCHCH3B217PhOCH3CH3HOHCHCH3B218PhSCH3CH3HOHCHCH3B219PhSO CH3CH3HOHCHCH3B220PhSO2CH3CH3HOHCHCH3基团R6R7R8R9R10 WB221CN CH3CH3H OHCHCH3B222CH3CH3CH3CH3OHCHCH3B223CH3CH2CH3CH3CH3OHCHCH3B224CH3CH2CH2CH3CH3CH3OHCHCH3B225(CH3)2CH CH3CH3CH3OHCHCH3B226(CH3)3C CH3CH3CH3OHCHCH3B227CH3S CH3CH3CH3OHCHCH3B228CH3SO CH3CH3CH3OHCHCH3B229CH3SO2CH3CH3CH3OHCHCH3B230Ph CH3CH3CH3OHCHCH3B231CH3O CH3CH3CH3OHCHCH3B232CH3OC(O) CH3CH3CH3OHCHCH3B233CH3CH2OC(O) CH3CH3CH3OHCHCH3B234CH2＝CHCH2CH3CH3CH3OHCHCH3B235HCCCH2CH3CH3CH3OHCHCH3B236CF3CH3CH3CH3OHCHCH3B237(CH3)2NSO2CH3CH3CH3OHCHCH3B238(CH3)2N CH3CH3CH3OHCHCH3B239PhOCH3CH3CH3OHCHCH3B240PhSCH3CH3CH3OHCHCH3B241PhSO CH3CH3CH3OHCHCH3B242PhSO2CH3CH3CH3OHCHCH3B243CN CH3CH3CH3OHCHCH3B244CH3CH2CH3CH2H H OHCHCH3B245CH3CH2CH2CH3CH2H H OHCHCH3B246(CH3)2CH CH3CH2H H OHCHCH3B247(CH3)3C CH3CH2H H OHCHCH3B248CH3S CH3CH2H H OHCHCH3B249CH3SO CH3CH2H H OHCHCH3B250CH3SO2CH3CH2H H OHCHCH3B251Ph CH3CH2H H OHCHCH3B252CH3O CH3CH2H H OHCHCH3B253CH3OC(O) CH3CH2H H OHCHCH3基团R6R7R8R9R10WB254CH3CH2OC(O)CH3CH2HHOHCHCH3B255CH2＝CHCH2CH3CH2HHOHCHCH3B256HCCCH2CH3CH2HHOHCHCH3B257CF3CH3CH2HHOHCHCH3B258(CH3)2NSO2CH3CH2HHOHCHCH3B259(CH3)2NCH3CH2HHOHCHCH3B260PhO CH3CH2HHOHCHCH3B261PhS CH3CH2HHOHCHCH3B262PhSO CH3CH2HHOHCHCH3B263PhSO2CH3CH2HHOHCHCH3B264CN CH3CH2HHOHCHCH3B265H H HHOHC＝OB266CH3H HHOHC＝OB267CH3CH2H HHOHC＝OB268CH3CH2CH2H HHOHC＝OB269(CH3)2CH H HHOHC＝OB270(CH3)3CH HHOHC＝OB271CH3SH HHOHC＝OB272CH3SO H HHOHC＝OB273CH3SO2H HHOHC＝OB274Ph H HHOHC＝OB275CH3OH HHOHC＝OB276CH3OC(O)H HHOHC＝OB277CH3CH2OC(O)H HHOHC＝OB278CH2＝CHCH2H HHOHC＝OB279HCCCH2H HHOHC＝OB280CF3H HHOHC＝OB281(CH3)2NSO2H HHOHC＝OB282(CH3)2NH HHOHC＝OB283PhO H HHOHC＝OB284PhS H HHOHC＝OB285PhSO H HHOHC＝OB286PhSO2H HHOHC＝O基团R6R7R8R9R10WB287CN H H HOHC＝OB288CH3CH3H HOHC＝OB289CH3CH2CH3H HOHC＝OB290CH3CH2CH2CH3H HOHC＝OB291(CH3)2CH CH3H HOHC＝OB292(CH3)3C CH3H HOHC＝OB293CH3S CH3H HOHC＝OB294CH3SO CH3H HOHC＝OB295CH3SO2CH3H HOHC＝OB296Ph CH3H HOHC＝OB297CH3O CH3H HOHC＝OB298CH3OC(O) CH3H HOHC＝OB299CH3CH2OC(O) CH3H HOHC＝OB300CH2＝CHCH2CH3H HOHC＝OB301HCCCH2CH3H HOHC＝OB302CF3CH3H HOHC＝OB303(CH3)2NSO2CH3H HOHC＝OB304(CH3)2N CH3H HOHC＝OB305PhOCH3H HOHC＝OB306PhSCH3H HOHC＝OB307PhSO CH3H HOHC＝OB308PhSO2CH3H HOHC＝OB309CN CH3H HOHC＝OB310CH3H CH3HOHC＝OB311CH3CH2H CH3HOHC＝OB312CH3CH2CH2H CH3HOHC＝OB313(CH3)2CH H CH3HOHC＝OB314(CH3)3C H CH3HOHC＝OB315CH3S H CH3HOHC＝OB316CH3SO H CH3HOHC＝OB317CH3SO2H CH3HOHC＝OB318Ph H CH3HOHC＝OB319CH3O H CH3HOHC＝O基团R6R7R8R9R10WB320CH3OC(O) H CH3HOHC＝O8321CH3CH2OC(O) H CH3HOHC＝OB322CH2＝CHCH2H CH3HOHC＝OB323HCCCH2H CH3HOHC＝OB324CF3H CH3HOHC＝OB325(CH3)2NSO2H CH3HOHC＝OB326(CH3)2N H CH3HOHC＝OB327PhOH CH3HOHC＝OB328PhSH CH3HOHC＝OB329PhSO H CH3HOHC＝OB330PhSO2H CH3HOHC＝OB331CN H CH3HOHC＝OB332CH3CH3CH3HOHC＝OB333CH3CH2CH3CH3HOHC＝OB334CH3CH2CH2CH3CH3HOHC＝OB335(CH3)2CH CH3CH3HOHC＝OB336(CH3)3C CH3CH3HOHC＝OB337CH3S CH3CH3HOHC＝OB338CH3SO CH3CH3HOHC＝OB339CH3SO2CH3CH3HOHC＝OB340Ph CH3CH3HOHC＝OB341CH3O CH3CH3HOHC＝OB342CH3OC(O) CH3CH3HOHC＝OB343CH3CH2OC(O) CH3CH3HOHC＝OB344CH2＝CHCH2CH3CH3HOHC＝OB345HCCCH2CH3CH3HOHC＝OB346CF3CH3CH3HOHC＝OB347(CH3)2NSO2CH3CH3HOHC＝OB348(CH3)2N CH3CH3HOHC＝OB349PhOCH3CH3HOHC＝OB350PhSCH3CH3HOHC＝OB351PhSO CH3CH3HOHC＝OB352PhSO2CH3CH3HOHC＝O基团R6R7R8R9R10WB353CN CH3CH3H OHC＝OB354CH3CH3CH3CH3OHC＝OB355CH3CH2CH3CH3CH3OHC＝OB356CH3CH2CH2CH3CH3CH3OHC＝OB357(CH3)2CH CH3CH3CH3OHC＝OB358(CH3)3C CH3CH3CH3OHC＝OB359CH3S CH3CH3CH3OHC＝OB360CH3SO CH3CH3CH3OHC＝OB361CH3SO2CH3CH3CH3OHC＝OB362Ph CH3CH3CH3OHC＝OB363CH3O CH3CH3CH3OHC＝OB364CH3OC(O) CH3CH3CH3OHC＝OB365CH3CH2OC(O) CH3CH3CH3OHC＝OB366CH2＝CHCH2CH3CH3CH3OHC＝OB367HCCCH2CH3CH3CH3OHC＝OB368CF3CH3CH3CH3OHC＝OB369(CH3)2NSO2CH3CH3CH3OHC＝OB370(CH3)2N CH3CH3CH3OHC＝OB371PhOCH3CH3CH3OHC＝OB372PhSCH3CH3CH3OHC＝OB373PhSO CH3CH3CH3OHC＝OB374PhSO2CH3CH3CH3OHC＝OB375CN CH3CH3CH3OHC＝OB376CH3CH2CH3CH2H H OHC＝OB377CH3CH2CH2CH3CH2H H OHC＝OB378(CH3)2CH CH3CH2H H OHC＝OB379(CH3)3C CH3CH2H H OHC＝OB380CH3S CH3CH2H H OHC＝OB381CH3SO CH3CH2H H OHC＝OB382CH3SO2CH3CH2H H OHC＝OB383Ph CH3CH2H H OHC＝OB384CH3O CH3CH2H H OHC＝OB385CH3OC(O) CH3CH2H H OHC＝O基团R6R7R8R9R10WB386CH3CH2OC(O)CH3CH2HHOHC＝OB387CH2＝CHCH2CH3CH2HHOHC＝OB388HCCCH2CH3CH2HHOHC＝OB389CF3CH3CH2HHOHC＝OB390(CH3)2NSO2CH3CH2HHOHC＝OB391(CH3)2NCH3CH2HHOHC＝OB392PhO CH3CH2HHOHC＝OB393PhS CH3CH2HHOHC＝OB394PhSO CH3CH2HHOHC＝OB395PhSO2CH3CH2HHOHC＝OB396CN CH3CH2HHOHC＝OB397HH HHOHN-CH3B398CH3H HHOHN-CH3B399CH3CH2H HHOHN-CH3B400CH3CH2CH2H HHOHN-CH3B401(CH3)2CH H HHOHN-CH3B402(CH3)3CH HHOHN-CH3B403CH3SH HHOHN-CH3B404CH3SO H HHOHN-CH3B405CH3SO2H HHOHN-CH3B406Ph H HHOHN-CH3B407CH3OH HHOHN-CH3B408CH3OC(O)H HHOHN-CH3B409CH3CH2OC(O)H HHOHN-CH3B410CH2＝CHCH2H HHOHN-CH3B411HCCCH2H HHOHN-CH3B412CF3H HHOHN-CH3B413(CH3)2NSO2H HHOHN-CH3B414(CH3)2NH HHOHN-CH3B415PhO H HHOHN-CH3B416PhS H HHOHN-CH3B417PhSO H HHOHN-CH3B418PhSO2H HHOHN-CH3基团R6R7R8R9R10WB419CN H HHOHN-CH3B420CH3CH3HHOHN-CH3B421CH3CH2CH3HHOHN-CH3B422CH3CH2CH2CH3HHOHN-CH3B423(CH3)2CH CH3HHOHN-CH3B424(CH3)3C CH3HHOHN-CH3B425CH3S CH3HHOHN-CH3B426CH3SO CH3HHOHN-CH3B427CH3SO2CH3HHOHN-CH3B428Ph CH3HHOHN-CH3B429CH3O CH3HHOHN-CH3B430CH3OC(O) CH3HHOHN-CH3B431CH3CH2OC(O) CH3HHOHN-CH3B432CH2＝CHCH2CH3HHOHN-CH3B433HCCCH2CH3HHOHN-CH3B434CF3CH3HHOHN-CH3B435(CH3)2NSO2CH3HHOHN-CH3B436(CH3)2N CH3HHOHN-CH3B437PhOCH3HHOHN-CH3B438PhSCH3HHOHN-CH3B439PhSO CH3HHOHN-CH3B440PhSO2CH3HHOHN-CH3B441CN CH3HHOHN-CH3B442CH3H CH3HOHN-CH3B443CH3CH2H CH3HOHN-CH3B444CH3CH2CH2H CH3HOHN-CH3B445(CH3)2CH H CH3HOHN-CH3B446(CH3)3C H CH3HOHN-CH3B447CH3S H CH3HOHN-CH3B448CH3SO H CH3HOHN-CH3B449CH3SO2H CH3HOHN-CH3B450Ph H CH3HOHN-CH3B451CH3O H CH3HOHN-CH3基团R6R7R8R9R10WB452CH3OC(O)H CH3HOHN-CH3B453CH3CH2OC(O)H CH3HOHN-CH3B454CH2＝CHCH2H CH3HOHN-CH3B455HCCCH2H CH3HOHN-CH3B456CF3H CH3HOHN-CH3B457(CH3)2NSO2H CH3HOHN-CH3B458(CH3)2NH CH3HOHN-CH3B459PhO H CH3HOHN-CH3B460PhS H CH3HOHN-CH3B461PhSO H CH3HOHN-CH3B462PhSO2H CH3HOHN-CH3B463CN H CH3HOHN-CH3B464CH3CH3CH3HOHN-CH3B465CH3CH2CH3CH3HOHN-CH3B466CH3CH2CH2CH3CH3HOHN-CH3B467(CH3)2CH CH3CH3HOHN-CH3B468(CH3)3CCH3CH3HOHN-CH3B469CH3SCH3CH3HOHN-CH3B470CH3SO CH3CH3HOHN-CH3B471CH3SO2CH3CH3HOHN-CH3B472Ph CH3CH3HOHN-CH3B473CH3OCH3CH3HOHN-CH3B474CH3OC(O)CH3CH3HOHN-CH3B475CH3CH2OC(O)CH3CH3HOHN-CH3B476CH2＝CHCH2CH3CH3HOHN-CH3B477HCCCH2CH3CH3HOHN-CH3B478CF3CH3CH3HOHN-CH3B479(CH3)2NSO2CH3CH3HOHN-CH3B480(CH3)2NCH3CH3HOHN-CH3B481PhO CH3CH3HOHN-CH3B482PhS CH3CH3HOHN-CH3B483PhSO CH3CH3HOHN-CH3B484PhSO2CH3CH3HOHN-CH3基团R6R7R8R9R10WB485CN CH3CH3H OHN-CH3B486CH3CH3CH3CH3OHN-CH3B487CH3CH2CH3CH3CH3OHN-CH3B488CH3CH2CH2CH3CH3CH3OHN-CH3B489(CH3)2CH CH3CH3CH3OHN-CH3B490(CH3)3C CH3CH3CH3OHN-CH3B491CH3S CH3CH3CH3OHN-CH3B492CH3SO CH3CH3CH3OHN-CH3B493CH3SO2CH3CH3CH3OHN-CH3B494Ph CH3CH3CH3OHN-CH3B495CH3O CH3CH3CH3OHN-CH3B496CH3OC(O) CH3CH3CH3OHN-CH3B497CH3CH2OC(O) CH3CH3CH3OHN-CH3B498CH2＝CHCH2CH3CH3CH3OHN-CH3B499HCCCH2CH3CH3CH3OHN-CH3B500CF3CH3CH3CH3OHN-CH3B501(CH3)2NSO2CH3CH3CH3OHN-CH3B502(CH3)2N CH3CH3CH3OHN-CH3B503PhOCH3CH3CH3OHN-CH3B504PhSCH3CH3CH3OHN-CH3B505PhSO CH3CH3CH3OHN-CH3B506PhSO2CH3CH3CH3OHN-CH3B507CN CH3CH3CH3OHN-CH3B508CH3CH2CH3CH2H H OHN-CH3B509CH3CH2CH2CH3CH2H H OHN-CH3B510(CH3)2CH CH3CH2H H OHN-CH3B511(CH3)3C CH3CH2H H OHN-CH3B512CH3S CH3CH2H H OHN-CH3B513CH3SO CH3CH2H H OHN-CH3B514CH3SO2CH3CH2H H OHN-CH3B515Ph CH3CH2H H OHN-CH3B516CH3O CH3CH2H H OHN-CH3B517CH3OC(O) CH3CH2H H OHN-CH3基团R6R7R8R9R10WB518CH3CH2OC(O)CH3CH2HHOHN-CH3B519CH2=CHCH2CH3CH2HHOHN-CH3B520HCCCH2CH3CH2HHOHN-CH3B521CF3CH3CH2HHOHN-CH3B522(CH3)2NSO2CH3CH2HHOHN-CH3B523(CH3)2NCH3CH2HHOHN-CH3B524PhO CH3CH2HHOHN-CH3B525PhS CH3CH2HHOHN-CH3B526PhSO CH3CH2HHOHN-CH3B527PhSO2CH3CH2HHOHN-CH3B528CN CH3CH2HHOHN-CH3B529H H HHOHOB530CH3H HHOHOB531CH3CH2H HHOHOB532CH3CH2CH2H HHOHOB533(CH3)2CH H HHOHOB534(CH3)3CH HHOHOB535CH3SH HHOHOB536CH3SO H HHOHOB537CH3SO2H HHOHOB538Ph H HHOHOB539CH3OH HHOHOB540CH3OC(O)H HHOHOB541CH3CH2OC(O)H HHOHOB542CH2=CHCH2H HHOHOB543HCCCH2H HHOHOB544CF3H HHOHOB545(CH3)2NSO2H HHOHOB546(CH3)2NH HHOHOB547PhO H HHOHOB548PhS H HHOHOB549PhSO H HHOHOB550PhSO2H HHOHO基团R6R7R8R9R10WB551CN H HHOHOB552CH3CH3HHOHOB553CH3CH2CH3HHOHOB554CH3CH2CH2CH3HHOHOB555(CH3)2CH CH3HHOHOB556(CH3)3C CH3HHOHOB557CH3S CH3HHOHOB558CH3SO CH3HHOHOB559CH3SO2CH3HHOHOB560Ph CH3HHOHOB561CH3O CH3HHOHOB562CH3OC(O) CH3HHOHOB563CH3CH2OC(O) CH3HHOHOB564CH2=CHCH2CH3HHOHOB565HCCCH2CH3HHOHOB566CF3CH3HHOHOB567(CH3)2NSO2CH3HHOHOB568(CH3)2N CH3HHOHOB569PhOCH3HHOHOB570PhSCH3HHOHOB571PhSO CH3HHOHOB572PhSO2CH3HHOHOB573CN CH3HHOHOB574CH3H CH3HOHOB575CH3CH2H CH3HOHOB576CH3CH2CH2H CH3HOHOB577(CH3)2CH H CH3HOHOB578(CH3)3C H CH3HOHOB579CH3S H CH3HOHOB580CH3SO H CH3HOHOB581CH3SO2H CH3HOHOB582Ph H CH3HOHOB583CH3O H CH3HOHO基团R6R7R8R9R10WB584CH3OC(O) H CH3HOHOB585CH3CH2OC(O) H CH3HOHOB586CH2＝CHCH2H CH3HOHOB587HCCCH2H CH3HOHOB588CF3H CH3HOHOB589 (CH3)2NSO2H CH3HOHOB590 (CH3)2N H CH3HOHOB591PhO H CH3HOHOB592PhS H CH3HOHOB593PhSOH CH3HOHOB594PhSO2H CH3HOHOB595CN H CH3HOHOB596CH3CH3CH3HOHOB597CH3CH2CH3CH3HOHOB598CH3CH2CH2CH3CH3HOHOB599(CH3)2CH CH3CH3HOHOB600(CH3)3C CH3CH3HOHOB601CH3S CH3CH3HOHOB602CH3SO CH3CH3HOHOB603CH3SO2CH3CH3HOHOB604Ph CH3CH3HOHOB605CH3O CH3CH3HOHOB606CH3OC(O) CH3CH3HOHOB607CH3CH2OC(O) CH3CH3HOHOB608CH2＝CHCH2CH3CH3HOHOB609 HCCCH2CH3CH3HOHOB610CF3CH3CH3HOHOB611(CH3)2NSO2CH3CH3HOHOB612(CH3)2N CH3CH3HOHOB613PhO CH3CH3HOHOB614PhS CH3CH3HOHOB615PhSOCH3CH3HOHOB616PhSO2CH3CH3HOHO基团R6R7R8R9R10WB617CN CH3CH3H OHOB618CH3CH3CH3CH3OHOB619CH3CH2CH3CH3CH3OHOB620CH3CH2CH2CH3CH3CH3OHOB621(CH3)2CH CH3CH3CH3OHOB622(CH3)3C CH3CH3CH3OHOB623CH3S CH3CH3CH3OHOB624CH3SO CH3CH3CH3OHOB625CH3SO2CH3CH3CH3OHOB626Ph CH3CH3CH3OHOB627CH3O CH3CH3CH3OHOB628CH3OC(O) CH3CH3CH3OHOB629CH3CH2OC(O) CH3CH3CH3OHOB630CH2＝CHCH2CH3CH3CH3OHOB631HCCCH2CH3CH3CH3OHOB632CF3CH3CH3CH3OHOB633(CH3)2NSO2CH3CH3CH3OHOB634(CH3)2N CH3CH3CH3OHOB635PhOCH3CH3CH3OHOB636PhSCH3CH3CH3OHOB637PhSO CH3CH3CH3OHOB638PhSO2CH3CH3CH3OHOB639CN CH3CH3CH3OHOB640CH3CH2CH3CH2H H OHOB641CH3CH2CH2CH3CH2H H OHOB642(CH3)2CHCH3CH2H H OHOB643(CH3)3C CH3CH2H H OHOB644CH3S CH3CH2H H OHOB645CH3SOCH3CH2H H OHOB646CH3SO2CH3CH2H H OHOB647PhCH3CH2H H OHOB648CH3O CH3CH2H H OHOB649CH3OC(O) CH3CH2H H OHO基团R6R7R8R9R10WB650CH3CH2OC(O)CH3CH2HHOHOB651CH2＝CHCH2CH3CH2HHOHOB652HCCCH2CH3CH2HHOHOB653CF3CH3CH2HHOHOB654(CH3)2NSO2CH3CH2HHOHOB655(CH3)2NCH3CH2HHOHOB656PhO CH3CH2HHOHOB657PhS CH3CH2HHOHOB658PhSO CH3CH2HHOHOB659PhSO2CH3CH2HHOHOB660CN CH3CH2HHOHOB661HH HHOHSB662CH3H HHOHSB663CH3CH2H HHOHSB664CH3CH2CH2H HHOHSB665(CH3)2CH H HHOHSB666(CH3)3CH HHOHSB667CH3SH HHOHSB668CH3SO H HHOHSB669CH3SO2H HHOHSB670Ph H HHOHSB671CH3OH HHOHSB672CH3OC(O)H HHOHSB673CH3CH2OC(O)H HHOHSB674CH2＝CHCH2H HHOHSB675HCCCH2H HHOHSB676CF3H HHOHSB677(CH3)2NSO2H HHOHSB678(CH3)2N H HHOHSB679PhO H HHOHSB680PhS H HHOHSB681PhSO H HHOHSB682PhSO2H HHOHS基团R6R7R8R9R10WB683CN H H HOHSB684CH3CH3H HOHSB685CH3CH2CH3H HOHSB686CH3CH2CH2CH3H HOHSB687(CH3)2CH CH3H HOHSB688(CH3)3C CH3H HOHSB689CH3S CH3H HOHSB690CH3SO CH3H HOHSB691CH3SO2CH3H HOHSB692Ph CH3H HOHSB693CH3O CH3H HOHSB694CH3OC(O) CH3H HOHSB695CH3CH2OC(O) CH3H HOHSB696CH2＝CHCH2CH3H HOHSB697HCCCH2CH3H HOHSB698CF3CH3H HOHSB699(CH3)2NSO2CH3H HOHSB700(CH3)2N CH3H HOHSB701PhOCH3H HOHSB702PhSCH3H HOHSB703PhSO CH3H HOHSB704PhSO2CH3H HOHSB705CN CH3H HOHSB706CH3H CH3HOHSB707CH3CH2H CH3HOHSB708CH3CH2CH2H CH3HOHSB709(CH3)2CH H CH3HOHSB710(CH3)3C H CH3HOHSB711CH3S H CH3HOHSB712CH3SO H CH3HOHSB713CH3SO2H CH3HOHSB714Ph H CH3HOHSB715CH3O H CH3HOHS基团R6R7R8R9R10WB716CH3OC(O)H CH3HOHSB717CH3CH2OC(O)H CH3HOHSB718CH2＝HCH2H CH3HOHSB719HCCCH2H CH3HOHSB720CF3H CH3HOHSB721(CH3)2NSO2H CH3HOHSB722(CH3)2NH CH3HOHSB723PhO H CH3HOHSB724PhS H CH3HOHSB725PhSO H CH3HOHSB726PhSO2H CH3HOHSB727CN H CH3HOHSB728CH3CH3CH3HOHSB729CH3CH2CH3CH3HOHSB730CH3CH2CH2CH3CH3HOHSB731(CH3)2CH CH3CH3HOHSB732(CH3)3CCH3CH3HOHSB733CH3SCH3CH3HOHSB734CH3SO CH3CH3HOHSB735CH3SO2CH3CH3HOHSB736Ph CH3CH3HOHSB737CH3OCH3CH3HOHSB738CH3OC(O)CH3CH3HOHSB739CH3CH2OC(O)CH3CH3HOHSB740CH2＝CHCH2CH3CH3HOHSB741HCCCH2CH3CH3HOHSB742CF3CH3CH3HOHSB743(CH3)2NSO2CH3CH3HOHSB744(CH3)2NCH3CH3HOHSB745PhO CH3CH3HOHSB746PhS CH3CH3HOHSB747PhSO CH3CH3HOHSB748PhSO2CH3CH3HOHS基团R6R7R8R9R10WB749CN CH3CH3H OHSB750CH3CH3CH3CH3OHSB751CH3CH2CH3CH3CH3OHSB752CH3CH2CH2CH3CH3CH3OHSB753(CH3)2CH CH3CH3CH3OHSB754(CH3)3C CH3CH3CH3OHSB755CH3S CH3CH3CH3OHSB756CH3SO CH3CH3CH3OHSB757CH3SO2CH3CH3CH3OHSB758Ph CH3CH3CH3OHSB759CH3O CH3CH3CH3OHSB760CH3OC(O) CH3CH3CH3OHSB761CH3CH2OC(O) CH3CH3CH3OHSB762CH2＝CHCH2CH3CH3CH3OHSB763HCCCH2CH3CH3CH3OHSB764CF3CH3CH3CH3OHSB765(CH3)2NSO2CH3CH3CH3OHSB766(CH3)2N CH3CH3CH3OHSB767PhOCH3CH3CH3OHSB768PhSCH3CH3CH3OHSB769PhSO CH3CH3CH3OHSB770PhSO2CH3CH3CH3OHSB771CN CH3CH3CH3OHSB772CH3CH2CH3CH2HH OHSB773CH3CH2CH2CH3CH2HH OHSB774(CH3)2CH CH3CH2HH OHSB775(CH3)3C CH3CH2HH OHSB776CH3S CH3CH2HH OHSB777CH3SO CH3CH2HH OHSB778CH3SO2CH3CH2HH OHSB779Ph CH3CH2HH OHSB780CH3O CH3CH2HH OHSB781CH3OC(O) CH3CH2HH OHS基团R6R7R8R9R10WB782CH3CH2OC(O)CH3CH2HHOHSB783CH2＝CHCH2CH3CH2HHOHSB784HCCCH2CH3CH2HHOHSB785CF3CH3CH2HHOHSB786(CH3)2NSO2CH3CH2HHOHSB787(CH3)2NCH3CH2HHOHSB788PhO CH3CH2HHOHSB789PhS CH3CH2HHOHSB790PhSO CH3CH2HHOHSB791PhSO2CH3CH2HHOHSB792CN CH3CH2HHOHSB793HH HHOHSO2B794CH3H HHOHSO2B795CH3CH2H HHOHSO2B796CH3CH2CH2H HHOHSO2B797(CH3)2CH H HHOHSO2B798(CH3)3CH HHOHSO2B799CH3SH HHOHSO2B800CH3SO H HHOHSO2B801CH3SO2H HHOHSO2B802Ph H HHOHSO2B803CH3OH HHOHSO2B804CH3OC(O)H HHOHSO2B805CH3CH2OC(O)H HHOHSO2B806CH2＝CHCH2H HHOHSO2B807HCCCH2H HHOHSO2B808CF3H HHOHSO2B809(CH3)2NSO2H HHOHSO2B810(CH3)2NH HHOHSO2B811PhO H HHOHSO2B812PhS H HHOHSO2B813PhSO H HHOHSO2B814PhSO2H HHOHSO2基团R6R7R8R9R10WB815CN H H H OHSO2B816CH3CH3H H OHSO2B817CH3CH2CH3H H OHSO2B818CH3CH2CH2CH3H H OHSO2B819(CH3)2CH CH3H H OHSO2B820(CH3)3CCH3H H OHSO2B821CH3SCH3H H OHSO2B822CH3SO CH3H H OHSO2B823CH3SO2CH3H H OHSO2B824Ph CH3H H OHSO2B825CH3OCH3H H OHSO2B826CH3OC(O)CH3H H OHSO2B827CH3CH2OC(O)CH3H H OHSO2B828CH2＝CHCH2CH3H H OHSO2B829HCCCH2CH3H H OHSO2B830CF3CH3H H OHSO2B831(CH3)2NSO2CH3H H OHSO2B832(CH3)2NCH3H H OHSO2B833PhO CH3H H OHSO2B834PhS CH3H H OHSO2B835PhSO CH3H H OHSO2B836PhSO2CH3H H OHSO2B837CN CH3H H OHSO2B838CH3H CH3H OHSO2B839CH3CH2H CH3H OHSO2B840CH3CH2CH2H CH3H OHSO2B841(CH3)2CH H CH3H OHSO2B842(CH3)3CH CH3H OHSO2B843CH3SH CH3H OHSO2B844CH3SO H CH3H OHSO2B845CH3SO2H CH3H OHSO2B846Ph H CH3H OHSO2B847CH3OH CH3H OHSO2基团R6R7R8R9R10WB848CH3OC(O)H CH3HOHSO2B849CH3CH2OC(O)H CH3HOHSO2B850CH2＝CHCH2H CH3HOHSO2B851HCCCH2H CH3HOHSO2B852CF3H CH3HOHSO2B853(CH3)2NSO2H CH3HOHSO2B854(CH3)2NH CH3HOHSO2B855PhO H CH3HOHSO2B856PhS H CH3HOHSO2B857PhSO H CH3HOHSO2B858PhSO2H CH3HOHSO2B859CN H CH3HOHSO2B860CH3CH3CH3HOHSO2B861CH3CH2CH3CH3HOHSO2B862CH3CH2CH2CH3CH3HOHSO2B863(CH3)2CH CH3CH3HOHSO2B864(CH3)3CCH3CH3HOHSO2B865CH3SCH3CH3HOHSO2B866CH3SO CH3CH3HOHSO2B867CH3SO2CH3CH3HOHSO2B868Ph CH3CH3HOHSO2B869CH3OCH3CH3HOHSO2B870CH3OC(O)CH3CH3HOHSO2B871CH3CH2OC(O)CH3CH3HOHSO2B872CH2＝CHCH2CH3CH3HOHSO2B873HCCCH2CH3CH3HOHSO2B874CF3CH3CH3HOHSO2B875(CH3)2NSO2CH3CH3HOHSO2B876(CH3)2NCH3CH3HOHSO2B877PhO CH3CH3HOHSO2B878PhS CH3CH3HOHSO2B879PhSO CH3CH3HOHSO2B880PhSO2CH3CH3HOHSO2基团R6R7R8R9R10WB881CN CH3CH3H OHSO2B882CH3CH3CH3CH3OHSO2B883CH3CH2CH3CH3CH3OHSO2B884CH3CH2CH2CH3CH3CH3OHSO2B885(CH3)2CH CH3CH3CH3OHSO2B886(CH3)3C CH3CH3CH3OHSO2B887CH3S CH3CH3CH3OHSO2B888CH3SO CH3CH3CH3OHSO2B889CH3SO2CH3CH3CH3OHSO2B890Ph CH3CH3CH3OHSO2B891CH3O CH3CH3CH3OHSO2B892CH3OC(O) CH3CH3CH3OHSO2B893CH3CH2OC(O) CH3CH3CH3OHSO2B894CH2＝CHCH2CH3CH3CH3OHSO2B895HCCCH2CH3CH3CH3OHSO2B896CF3CH3CH3CH3OHSO2B897(CH3)2NSO2CH3CH3CH3OHSO2B898(CH3)2N CH3CH3CH3OHSO2B899PhOCH3CH3CH3OHSO2B900PhSCH3CH3CH3OHSO2B901PhSO CH3CH3CH3OHSO2B902PhSO2CH3CH3CH3OHSO2B903CN CH3CH3CH3OHSO2B904CH3CH2CH3CH2H H OHSO2B905CH3CH2CH2CH3CH2H H OHSO2B906(CH3)2CH CH3CH2H H OHSO2B907(CH3)3C CH3CH2H H OHSO2B908CH3S CH3CH2H H OHSO2B909CH3SO CH3CH2H H OHSO2B910CH3SO2CH3CH2H H OHSO2B911Ph CH3CH2H H OHSO2B912CH3O CH3CH2H H OHSO2B913CH3OC(O) CH3CH2H H OHSO2基团R6R7R8R9R10WB914CH3CH2OC(O)CH3CH2H HOHSO2B915CH2＝CHCH2CH3CH2H HOHSO2B916HCCCH2CH3CH2H HOHSO2B917CF3CH3CH2H HOHSO2B918(CH3)2NSO2CH3CH2H HOHSO2B919(CH3)2NCH3CH2H HOHSO2B920PhO CH3CH2H HOHSO2B921PhS CH3CH2H HOHSO2B922PhSO CH3CH2H HOHSO2B923PhSO2CH3CH2H HOHSO2B924CN CH3CH2H HOHSO2B925HH H HOHCHC(O)OCH2CH3B926CH3H H HOHCHC(O)OCH2CH3B927CH3CH2H H HOHCHC(O)OCH2CH3B928CH3CH2CH2H H HOHCHC(O)OCH2CH3B929(CH3)2CH H H HOHCHC(O)OCH2CH3B930(CH3)3CH H HOHCHC(O)OCH2CH3B931CH3SH H HOHCHC(O)OCH2CH3B932CH3SO H H HOHCHC(O)OCH2CH3B933CH3SO2H H HOHCHC(O)OCH2CH3B934Ph H H HOHCHC(O)OCH2CH3B935CH3OH H HOHCHC(O)OCH2CH3B936CH3OC(O)H H HOHCHC(O)OCH2CH3B937CH3CH2OC(O)H H HOHCHC(O)OCH2CH3B938CH2＝CHCH2H H HOHCHC(O)OCH2CH3B939HCCCH2H H HOHCHC(O)OCH2CH3B940CF3H H HOHCHC(O)OCH2CH3B941(CH3)2NSO2H H HOHCHC(O)OCH2CH3B942(CH3)2NH H HOHCHC(O)OCH2CH3B943PhO H H HOHCHC(O)OCH2CH3B944PhS H H HOHCHC(O)OCH2CH3B945PhSO H H HOHCHC(O)OCH2CH3B946PhSO2H H HOHCHC(O)OCH2CH3基团R6R7R8R9R10WB947CN H H HOHCHC(O)OCH2CH3B948CH3CH3H HOHCHC(O)OCH2CH3B949CH3CH2CH3H HOHCHC(O)OCH2CH3B950CH3CH2CH2CH3H HOHCHC(O)OCH2CH3B951(CH3)2CH CH3H HOHCHC(O)OCH2CH3B952(CH3)3C CH3H HOHCHC(O)OCH2CH3B953CH3S CH3H HOHCHC(O)OCH2CH3B954CH3SO CH3H HOHCHC(O)OCH2CH3B955CH3SO2CH3H HOHCHC(O)OCH2CH3B956Ph CH3H HOHCHC(O)OCH2CH3B957CH3O CH3H HOHCHC(O)OCH2CH3B958CH3OC(O) CH3H HOHCHC(O)OCH2CH3B959CH3CH2OC(O) CH3H HOHCHC(O)OCH2CH3B960CH2＝CHCH2CH3H HOHCHC(O)OCH2CH3B961HCCCH2CH3H HOHCHC(O)OCH2CH3B962CF3CH3H HOHCHC(O)OCH2CH3B963(CH3)2NSO2CH3H HOHCHC(O)OCH2CH3B964(CH3)2N CH3H HOHCHC(O)OCH2CH3B965PhOCH3H HOHCHC(O)OCH2CH3B966PhSCH3H HOHCHC(O)OCH2CH3B967PhSO CH3H HOHCHC(O)OCH2CH3B968PhSO2CH3H HOHCHC(O)OCH2CH3B969CN CH3H HOHCHC(O)OCH2CH3B970CH3H CH3HOHCHC(O)OCH2CH3B971CH3CH2H CH3HOHCHC(O)OCH2CH3B972CH3CH2CH2H CH3HOHCHC(O)OCH2CH3B973(CH3)2CH H CH3HOHCHC(O)OCH2CH3B974(CH3)3C H CH3HOHCHC(O)OCH2CH3B975CH3S H CH3HOHCHC(O)OCH2CH3B976CH3SO H CH3HOHCHC(O)OCH2CH3B977CH3SO2H CH3HOHCHC(O)OCH2CH3B978Ph H CH3HOHCHC(O)OCH2CH3B979CH3O H CH3HOHCHC(O)OCH2CH3基团 R6R7R8R9R10WB980 CH3OC(O)H CH3HOHCHC(O)OCH2CH3B981 CH3CH2OC(O)H CH3HOHCHC(O)OCH2CH3B982 CH2＝CHCH2H CH3HOHCHC(O)OCH2CH3B983 HCCCH2H CH3HOHCHC(O)OCH2CH3B984 CF3H CH3HOHCHC(O)OCH2CH3B985 (CH3)2NSO2H CH3HOHCHC(O)OCH2CH3B986 (CH3)2NH CH3HOHCHC(O)OCH2CH3B987 PhO H CH3HOHCHC(O)OCH2CH3B988 PhS H CH3HOHCHC(O)OCH2CH3B989 PhSO H CH3HOHCHC(O)OCH2CH3B990 PhSO2H CH3HOHCHC(O)OCH2CH3B991 CN H CH3HOHCHC(O)OCH2CH3B992 CH3CH3CH3HOHCHC(O)OCH2CH3B993 CH3CH2CH3CH3HOHCHC(O)OCH2CH3B994 CH3CH2CH2CH3CH3HOHCHC(O)OCH2CH3B995 (CH3)2CH CH3CH3HOHCHC(O)OCH2CH3B996 (CH3)3CCH3CH3HOHCHC(O)OCH2CH3B997 CH3SCH3CH3HOHCHC(O)OCH2CH3B998 CH3SO CH3CH3HOHCHC(O)OCH2CH3B999 CH3SO2CH3CH3HOHCHC(O)OCH2CH3B1000Ph CH3CH3HOHCHC(O)OCH2CH3B1001CH3OCH3CH3HOHCHC(O)OCH2CH3B1002CH3OC(O)CH3CH3HOHCHC(O)OCH2CH3B1003CH3CH2OC(O)CH3CH3HOHCHC(O)OCH2CH3B1004CH2＝CHCH2CH3CH3HOHCHC(O)OCH2CH3B1005HCCCH2CH3CH3HOHCHC(O)OCH2CH3B1006CF3CH3CH3HOHCHC(O)OCH2CH3B1007(CH3)2NSO2CH3CH3HOHCHC(O)OCH2CH3B1008(CH3)2NCH3CH3HOHCHC(O)OCH2CH3B1009PhO CH3CH3HOHCHC(O)OCH2CH3B1010PhS CH3CH3HOHCHC(O)OCH2CH3B1011PhSO CH3CH3HOHCHC(O)OCH2CH3B1012PhSO2CH3CH3HOHCHC(O)OCH2CH3基团 R6R7R8R9R10WB1013CN CH3CH3H OHCHC(O)OCH2CH3B1014CH3CH3CH3CH3OHCHC(O)OCH2CH3B1015CH3CH2CH3CH3CH3OHCHC(O)OCH2CH3B1016CH3CH2CH2CH3CH3CH3OHCHC(O)OCH2CH3B1017(CH3)2CH CH3CH3CH3OHCHC(O)OCH2CH3B1018(CH3)3C CH3CH3CH3OHCHC(O)OCH2CH3B1019CH3S CH3CH3CH3OHCHC(O)OCH2CH3B1020CH3SO CH3CH3CH3OHCHC(O)OCH2CH3B1021CH3SO2CH3CH3CH3OHCHC(O)OCH2CH3B1022Ph CH3CH3CH3OHCHC(O)OCH2CH3B1023CH3O CH3CH3CH3OHCHC(O)OCH2CH3B1024CH3OC(O) CH3CH3CH3OHCHC(O)OCH2CH3B1025CH3CH2OC(O) CH3CH3CH3OHCHC(O)OCH2CH3B1026CH2＝CHCH2CH3CH3CH3OHCHC(O)OCH2CH3B1027HCCCH2CH3CH3CH3OHCHC(O)OCH2CH3B1028CF3CH3CH3CH3OHCHC(O)OCH2CH3B1029(CH3)2NSO2CH3CH3CH3OHCHC(O)OCH2CH3B1030(CH3)2N CH3CH3CH3OHCHC(O)OCH2CH3B1031PhO CH3CH3CH3OHCHC(O)OCH2CH3B1032PhS CH3CH3CH3OHCHC(O)OCH2CH3B1033PhSOCH3CH3CH3OHCHC(O)OCH2CH3B1034PhSO2CH3CH3CH3OHCHC(O)OCH2CH3B1035CN CH3CH3CH3OHCHC(O)OCH2CH3B1036CH3CH2CH3CH2HH OHCHC(O)OCH2CH3B1037CH3CH2CH2CH3CH2HH OHCHC(O)OCH2CH3B1038(CH3)2CH CH3CH2HH OHCHC(O)OCH2CH3B1039(CH3)3C CH3CH2HH OHCHC(O)OCH2CH3B1040CH3S CH3CH2HH OHCHC(O)OCH2CH3B1041CH3SO CH3CH2HH OHCHC(O)OCH2CH3B1042CH3SO2CH3CH2HH OHCHC(O)OCH2CH3B1043Ph CH3CH2HH OHCHC(O)OCH2CH3B1044CH3O CH3CH2HH OHCHC(O)OCH2CH3B1045CH3OC(O) CH3CH2HH OHCHC(O)OCH2CH3基团 R6R7R8R9R10WB1046CH3CH2OC(O) CH3CH2HHOHCHC(O)OCH2CH3B1047CH2＝CHCH2CH3CH2HHOHCHC(O)OCH2CH3B1048HCCCH2CH3CH2HHOHCHC(O)OCH2CH3B1049CF3CH3CH2HHOHCHC(O)OCH2CH3B1050(CH3)2NSO2CH3CH2HHOHCHC(O)OCH2CH3B1051(CH3)2N CH3CH2HHOHCHC(O)OCH2CH3B1052PhOCH3CH2HHOHCHC(O)OCH2CH3B1053PhSCH3CH2HHOHCHC(O)OCH2CH3B1054PhSO CH3CH2HHOHCHC(O)OCH2CH3B1055PhSO2CH3CH2HHOHCHC(O)OCH2CH3B1056CN CH3CH2HHOHCHC(O)OCH2CH3B1057CH3OC(O) H HHOHCHPhB1058H H HHOHCHPhB1059H H HHOHCH(CH2CH3)B1060H H HHOHCH(CH2CH2CH3)B1061H H HHOHCH(CH(CH3)2)B1062H H HHOHCH(C(CH3)3)B1063H H HHOHC(CH3)2B1064H H HHOHCH(CF3)B1065CH3OC(O) H HHOHC(CH3)(CF3)B1066H H HHOHC(CH3)(CF3)B1067CH3OC(O) CH3O HHOHCH2B1068H CH3O HHOHCH2B1069CH3O CH3OC(O) HCH3OHCH2B1070CH3O H CH3HOHCH2B1071Cl H HHOHCH2B1072F H HHOHCH2B1073H H HHOHCH(OCH3)2B1074H H HHOHCH2OSO2CH3B1075CH3CH3CH3CH3OHS(O)B1076ClCH2CH2H HHOHCH2B1077HO(CH2)2H HHOHCH2B1078MsO(CH2)2H HHOHCH2基团 R6R7R8R9R10WB1079HOCH(CH3)CH2H H H OHCH2B1080MsOCH(CH3)CH2H H H OHCH2B1081(CH3)2CH H CH3CH3OHCH2B1082HCCCH2H CH3CH3OHCH2B1083H2C＝CCH2H CH3CH3OHCH2B1084H2C＝C(CH3) H H H OHCHCH3B1085H H H H OHCHCONHCH2PhB1086H H H H OH B1087CH3OC(O) CH3H H OHC(CH3)2B1088H H H H OH B1089CH3CH2H CH3CH3OHCH2B1090CH3OC(O) H H H OHCF3CH2CH2B1091CH3CH2S CH3CH2CH3H OHCH2B1092CH3S PhCH3H OHCH2B1093CH3CH2CH3CH2CH3H OHCH2B1094CH3OC(O) H H H OHC(CH3)2B1095CH3H H H OHC(CH3)2B1096H H H H OHNCOCH2SCH3B1097H H H OHCH2B1098 1，1-二甲基乙烯基 H H H OHCH2B1099 H H H OHCH2B1100H H H H -ONH＋(CH2CH3)3CH2B1101H H H H -ONH＋(CH2CH3)3CH(CH3)B1102H H H H PhS CH2B1103H H H H PhSO CH2B1104H H H H PhSO2CH2B1105CH3CH3CH3CH3ClC＝OB1106H H H H OHCHCH2CH(CH3)2基团 R6R7R8R9R10WB1107CH3CH3CH3CH3CH3C(O)O C＝OB1108CH3OC(O)CH2H H H OH CH2B1109CH3OC(O)CH2CH3H H OH CH2B1110CH3OC(O)CH2CH3CH3H OH CH2B1111CH3OC(O)CH2CH3CH3CH3OH CH2B1112CH3OC(O)CH2H CH3CH3OH CH2B1113CH3OC(O)CH2H H H OH CH(CH3)B1114CH3OC(O)CH2CH3H H OH CH(CH3)B1115CH3OC(O)CH2CH3CH3H OH CH(CH3)B1116CH3OC(O)CH2CH3CH3CH3OH CH(CH3)B1117CH3OC(O)CH2H CH3CH3OH CH(CH3)B1118CH3OC(O)CH2H H H OH C(CH3)2B1119CH3OC(O)CH2CH3H H OH C(CH3)2B1120CH3OC(O)CH2CH3CH3H OH C(CH3)2B1121CH3OC(O)CH2CH3CH3CH3OH C(CH3)2B1122CH3OC(O)CH2H CH3CH3OH C(CH3)2B1123 CH3CH2OC(O)CH2H H H OH CH2B1124 CH3CH2OC(O)CH2CH3H H OH CH2B1125 CH3CH2OC(O)CH2CH3CH3H OH CH2B1126 CH3CH2OC(O)CH2CH3CH3CH3OH CH2B1127 CH3CH2OC(O)CH2H CH3CH3OH CH2B1128 CH3CH2OC(O)CH2H H H OH CH(CH3)B1129 CH3CH2OC(O)CH2CH3H H OH CH(CH3)B1130 CH3CH2OC(O)CH2CH3CH3H OH CH(CH3)B1131 CH3CH2OC(O)CH2CH3CH3CH3OH CH(CH3)B1132 CH3CH2OC(O)CH2H CH3CH3OH CH(CH3)B1133 CH3CH2OC(O)CH2H H H OH C(CH3)2B1134 CH3CH2OC(O)CH2CH3H H OH C(CH3)2B1135 CH3CH2OC(O)CH2CH3CH3H OH C(CH3)2B1136 CH3CH2OC(O)CH2CH3CH3CH3OH C(CH3)2B1137 CH3CH2OC(O)CH2H CH3CH3OH C(CH3)2B1138 CH3H H OH CH2基团 R6R7R8R9R10WB1139CH3SCH2H H H OHCH2B1140CH3SCH2CH3H H OHCH2B1141CH3SCH2CH3CH3H OHCH2B1142CH3SCH2CH3CH3CH3OHCH2B1143CH3SCH2H CH3CH3OHCH2B1144CH3SOCH2H H H OHCH2B1145CH3SOCH2CH3H H OHCH2B1146CH3SOCH2CH3CH3H OHCH2B1147CH3SOCH2CH3CH3CH3OHCH2B1148CH3SOCH2H CH3CH3OHCH2B1149CH3SO2CH2H H H OHCH2B1150CH3SO2CH2CH3H H OHCH2B1151CH3SO2CH2CH3CH3H OHCH2B1152CH3SO2CH2CH3CH3CH3OHCH2B1153CH3SO2CH2H CH3CH3OHCH2B1154HOCH2H H H OHCH2B1155HOCH2CH3H H OHCH2B1156HOCH2CH3CH3H OHCH2B1157HOCH2CH3CH3CH3OHCH2B1158HOCH2H CH3CH3OHCH2B1159NCCH2H H H OHCH2B1160NCCH2CH3H H OHCH2B1161NCCH2CH3CH3H OHCH2B1162NCCH2CH3CH3CH3OHCH2B1163NCCH2H CH3CH3OHCH2B1164CH3C(O)OCH2H H H OHCH2B1165CH3C(O)OCH2CH3H H OHCH2B1166CH3C(O)OCH2CH3CH3H OHCH2B1167CH3C(O)OCH2CH3CH3CH3OHCH2B1168CH3C(O)OCH2H CH3CH3OHCH2B1169CH3OCH2H H H OHCH2B1170CH3OCH2CH3H H OHCH2B1171CH3OCH2CH3CH3H OHCH2基团 R6R7R8R9R10WB1172CH3OCH2CH3CH3CH3OHCH2B1173CH3OCH2H CH3CH3OHCH2B1174PhCH2H H HOHCH2B1175PhCH2CH3H HOHCH2B1176PhCH2CH3CH3HOHCH2B1177PhCH2CH3CH3CH3OHCH2B1178PhCH2H CH3CH3OHCH2B1179H H H HO-K+ CH2B1180H H H HS(CH2)7CH3CH2B1181H H H HS(CH2)7CH3CH2B1182H H H HSO(CH2)7CH3CH2B1183H H H HSO2(CH2)7CH3CH2B1184H H H HNHSO2CH3CH2B1185H H H HNH(CO)S(CH2)7CH3CH2B1186H H H HClCH2B1187H H H HNH2CH2B1188H H H HOC(O)C(CH3)3CH2B1189H H H HOC(O)CH3CH2B1190H H H HOC(O)Ph CH2B1191H H H HOC(O)-环丙基 CH2B1192H H H HOC(O)CH2CH3CH2B1193H H H HOC(O)CH＝CH2CH2B1194H H H HOC(O)CH＝CHCH3CH2B1195H H H HOC(O)SCH3CH2B1196H H H HOC(O)S(CH2)7CH3CH2B1197H H H HOC(O)OCH2CH3CH2B1198H H H HOC(O)N(CH2CH3)2CH2B1199H H H HS-(4-Cl-苯基) CH2B1200H H H HSO-(4-Cl-苯基)CH2B1201H H H HSO2-(4-Cl-苯基) CH2B1202H H H HS-(4-CF3-苯基) CH2B1203H H H HSO-(4-CF3-苯基) CH2B1204H H H HSO2-(4-CF3-苯基)CH2基团 R6R7R8R9R10WB1205H H H HS-(4-NO2-苯基)CH2B1206H H H HSO-(4-NO2-苯基) CH2B1207H H H HSO2-(4-NO2-苯基) CH2B1208H H H H CH2B1209H H H H CH2B1210H H H HCH2B1211H H H H CH2B1212H H H H CH2B1179CH3CH3HHO-K+CH2B1180CH3CH3HHS(CH2)7CH3CH2B1181CH3CH3HHS(CH2)7CH3CH2B1182CH3CH3HHSO(CH2)7CH3CH2B1183CH3CH3HHSO2(CH2)7CH3CH2B1184CH3CH3HHNHSO2CH3CH2B1185CH3CH3HHNH(CO)S(CH2)7CH3CH2B1186CH3CH3HHCl CH2B1187CH3CH3HHNH2CH2B1188CH3CH3HHOC(O)C(CH3)3CH2B1189CH3CH3HHOC(O)CH3CH2B1190CH3CH3HHOC(O)PhCH2B1191CH3CH3HHOC(O)-环丙基 CH2B1192CH3CH3HHOC(O)CH2CH3CH2B1193CH3CH3HHOC(O)CH＝CH2CH2B1194CH3CH3HHOC(O)CH＝CHCH3CH2B1195CH3CH3HHOC(O)SCH3CH2B1196CH3CH3HHOC(O)S(CH2)7CH3CH2B1197CH3CH3HHOC(O)OCH2CH3CH2B1198CH3CH3HHOC(O)N(CH2CH3)2CH2B1199CH3CH3HHS-(4-Cl-苯基) CH2B1200CH3CH3HHSO-(4-Cl-苯基) CH2基团 R6R7R8R9R10WB1201CH3CH3HHSO2-(4-Cl-苯基) CH2B1202CH3CH3HHS-(4-CF3-苯基)CH2B1203CH3CH3HHSO-(4-CF3-苯基) CH2B1204CH3CH3HHSO2-(4-CF3-苯基) CH2B1205CH3CH3HHS-(4-NO2-苯基)CH2B1206CH3CH3HHSO-(4-NO2-苯基CH2B1207CH3CH3HHSO2-(4-NO2-苯基) CH2B1208CH3CH3HHCH2B1209CH3CH3HH CH2B1210CH3CH3HHCH2B1211CH3CH3HH CH2B1212CH3CH3HH CH2B1213H H HHOH -CH2CH2-B1214CH3H HHOH -CH2CH2-B1215CH3CH3HHOH -CH2CH2-B1216CH3CH3CH3HOH -CH2CH2-B1217CH3CH3CH3CH3OH -CH2CH2-下表3中，Q代表Q2 且Q2代表下列基团C表3基团C基团 R6R7R16R10pW基团 R6R7R16R10p WC1 H H HOH 1CH2C2 CH3H HOH 1CH2C3 CH3CH2H HOH 1CH2C4 CH3CH2CH2H HOH 1CH2C5 (CH3)2CH H HOH 1CH2C6 (CH3)3C H HOH 1CH2C7 CH3S H HOH 1CH2C8 CH3SO H HOH 1CH2C9 CH3SO2H HOH 1CH2C10Ph H HOH 1CH2C11CH3O H HOH 1CH2C12CH3OC(O) H HOH 1CH2C13CH3CH2OC(O) H HOH 1CH2C14CH2＝CHCH2H HOH 1CH2C15HCCCH2H HOH 1CH2C16CF3H HOH 1CH2C17(CH3)2NSO2H HOH 1CH2C18(CH3)2N H HOH 1CH2C19PhOH HOH 1CH2C20PhSH HOH 1CH2C21PhSO H HOH 1CH2C22PhSO2H HOH 1CH2C23CN H HOH 1CH2C24CH3CH3HOH 1CH2C25CH3CH2CH3HOH 1CH2C26CH3CH2CH2CH3HOH 1CH2C27(CH3)2CH CH3HOH 1CH2C28(CH3)3C CH3HOH 1CH2C29CH3S CH3HOH 1CH2C30CH3SO CH3HOH 1CH2C31CH3SO2CH3HOH 1CH2C32Ph CH3HOH 1CH2基团R6R7R16R10pWC33CH3OCH3HOH 1CH2C34CH3OC(O)CH3HOH 1CH2C35CH3CH2OC(O)CH3HOH 1CH2C36CH2=CHCH2CH3HOH 1CH2C37HCCCH2CH3HOH 1CH2C38CF3CH3HOH 1CH2C39(CH3)2NSO2CH3HOH 1CH2C40(CH3)2NCH3HOH 1CH2C41PhO CH3HOH 1CH2C42PhS CH3HOH 1CH2C43PhSO CH3HOH 1CH2C44PhSO2CH3HOH 1CH2C45CN CH3HOH 1CH2C46HH HOH 4CH2C47CH3H HOH 4CH2C48CH3CH2H HOH 4CH2C49CH3CH2CH2H HOH 4CH2C50(CH3)2CH H HOH 4CH2C51(CH3)3CH HOH 4CH2C52CH3SH HOH 4CH2C53CH3SO H HOH 4CH2C54CH3SO2H HOH 4CH2C55Ph H HOH 4CH2C56CH3OH HOH 4CH2C57CH3OC(O)H HOH 4CH2C58CH3CH2OC(O)H HOH 4CH2C59CH2=CHCH2H HOH 4CH2C60HCCCH2H HOH 4CH2C61CF3H HOH 4CH2C62(CH3)2NSO2H HOH 4CH2C63(CH3)2NH HOH 4CH2C64PhO H HOH 4CH2C65PhS H HOH 4CH2基团 R6R7R16R10pWC66PhSO H HOH 4CH2C67PhSO2H HOH 4CH2C68CN H HOH 4CH2C69CH3CH3HOH 4CH2C70CH3CH2CH3HOH 4CH2C71CH3CH2CH2CH3HOH 4CH2C72(CH3)2CH CH3HOH 4CH2C73(CH3)3C CH3HOH 4CH2C74CH3S CH3HOH 4CH2C75CH3SO CH3HOH 4CH2C76CH3SO2CH3HOH 4CH2C77Ph CH3HOH 4CH2C78CH3O CH3HOH 4CH2C79CH3OC(O) CH3HOH 4CH2C80CH3CH2OC(O) CH3HOH 4CH2C81CH2＝CHCH2CH3HOH 4CH2C82HCCCH2CH3HOH 4CH2C83CF3CH3HOH 4CH2C84(CH3)2NSO2CH3HOH 4CH2C85(CH3)2N CH3HOH 4CH2C86PhOCH3HOH 4CH2C87PhSCH3HOH 4CH2C88PhSO CH3HOH 4CH2C89PhSO2CH3HOH 4CH2C90CN CH3HOH 4CH2C91H H HOH 3CH2C92CH3H HOH 3CH2C93CH3CH2H HOH 3CH2C94CH3CH2CH2H HOH 3CH2C95(CH3)2CH H HOH 3CH2C96(CH3)3C H HOH 3CH2C97CH3S H HOH 3CH2C98CH3SO H HOH 3CH2基团R6R7R16R10pWC99 CH3SO2H HOH 3CH2C100Ph H HOH 3CH2C101CH3O H HOH 3CH2C102CH3OC(O) H HOH 3CH2C103CH3CH2OC(O) H HOH 3CH2C104CH2＝CHCH2H HOH 3CH2C105HCCCH2H HOH 3CH2C106CF3H HOH 3CH2C107(CH3)2NSO2H HOH 3CH2C108(CH3)2N H HOH 3CH2C109PhO H HOH 3CH2C110PhS H HOH 3CH2C111PhSOH HOH 3CH2C112PhSO2H HOH 3CH2C113CN H HOH 3CH2C114CH3CH3HOH 3CH2C115CH3CH2CH3HOH 3CH2C116CH3CH2CH2CH3HOH 3CH2C117(CH3)2CH CH3HOH 3CH2C118(CH3)3C CH3HOH 3CH2C119CH3S CH3HOH 3CH2C120CH3SO CH3HOH 3CH2C121CH3SO2CH3HOH 3CH2C122Ph CH3HOH 3CH2C123CH3O CH3HOH 3CH2C124CH3OC(O) CH3HOH 3CH2C125CH3CH2OC(O) CH3HOH 3CH2C126CH2＝CHCH2CH3HOH 3CH2C127HCCCH2CH3HOH 3CH2C128CF3CH3HOH 3CH2C129(CH3)2NSO2CH3HOH 3CH2C130(CH3)2N CH3HOH 3CH2C131PhO CH3HOH 3CH2基团R6R7R16R10pWC132PhS CH3HOH 3CH2C133PhSOCH3HOH 3CH2C134PhSO2CH3HOH 3CH2C135CN CH3HOH 3CH2C136CH3CH2CH3CH2HOH 1CH2C137H H HOH 1CH(CH3)C138CH3H HOH 1CH(CH3)C139CH3CH3HOH 1CH(CH3)C140CH2CH3H HOH 1CH(CH3)C141CH2CH3CH3HOH 1CH(CH3)C142 CH3CH2CH3CH2HOH 1CH(CH3)C143H H CH3OH 1CH2C144CH3CH3CH3OH 1CH2C145 CH3CH2CH3CH2CH3OH 1CH2C146H H HOH 2CH2C147CH3CH3HOH 2CH2C148CH2CH2CH3CH2HOH 2CH2C149H H HOH 5CH2C150CH3CH3HOH 5CH2C151CH3CH2CH3CH2HOH 5CH2C152CH3H HOH 2CH2下表4中，Q代表Q3 并且 Q3代表下列基团D表4基团D基团R6R7R8R12R10o基团 R6R7R8R12R10oD1 H H HHOH 2D2 CH3H HHOH 2D3 CH3CH2H HHOH 2D4 CH3CH2CH2H HHOH 2D5 (CH3)2CH H HHOH 2D6 (CH3)3C H HHOH 2D7 CH3S H HHOH 2D8 CH3SO H HHOH 2D9 CH3SO2H HHOH 2D10Ph H HHOH 2D11CH3O H HHOH 2D12CH2＝CHCH2H HHOH 2D13HCCCH2H HHOH 2D14CF3H HHOH 2D15PhO H HHOH 2D16PhS H HHOH 2D17PhSOH HHOH 2D18PhSO2H HHOH 2D19CH3CH3HHOH 2D20CH3CH2CH3HHOH 2D21CH3CH2CH2CH3HHOH 2D22(CH3)2CH CH3HHOH 2D23(CH3)3C CH3HHOH 2D24CH3S CH3HHOH 2D25CH3SO CH3HHOH 2D26CH3SO2CH3HHOH 2D27Ph CH3HHOH 2D28CH3O CH3HHOH 2D29CH2＝CHCH2CH3HHOH 2D30HCCCH2CH3HHOH 2D31CF3CH3HHOH 2D32PhO CH3HHOH 2基团 R6R7R8R12R10oD33PhS CH3HHOH 2D34PhSO CH3HHOH 2D35PhSO2CH3HHOH 2D36HH HHOH 3D37CH3H HHOH 3D38CH3CH2H HHOH 3D39CH3CH2CH2H HHOH 3D40(CH3)2CH H HHOH 3D41(CH3)3CH HHOH 3D42CH3SH HHOH 3D43CH3SO H HHOH 3D44CH3SO2H HHOH 3D45Ph H HHOH 3D46CH3OH HHOH 3D47CH2＝CHCH2H HHOH 3D48HCCCH2H HHOH 3D49CF3H HHOH 3D50PhO H HHOH 3D51PhS H HHOH 3D52PhSO H HHOH 3D53PhSO2H HHOH 3D54CH3CH3HHOH 3D55CH3CH2CH3HHOH 3D56CH3CH2CH2CH3HHOH 3D57(CH3)2CH CH3HHOH 3D58(CH3)3CCH3HHOH 3D59CH3SCH3HHOH 3D60CH3SO CH3HHOH 3D61CH3SO2CH3HHOH 3D62Ph CH3HHOH 3D63CH3OCH3HHOH 3D64CH2＝CHCH2CH3HHOH 3D65HCCCH2CH3HHOH 3基团R6R7R8R12R10oD66CF3CH3HHOH 3D67PhO CH3HHOH 3D68PhS CH3HHOH 3D69PhSO CH3HHOH 3D70PhSO2CH3HHOH 3D71HH HHOH 4D72CH3H HHOH 4D73CH3CH2H HHOH 4D74CH3CH2CH2H HHOH 4D75(CH3)2CH H HHOH 4D76(CH3)3CH HHOH 4D77CH3SH HHOH 4D78CH3SO H HHOH 4D79CH3SO2H HHOH 4D80PhH HHOH 4D81CH3OH HHOH 4D82CH2＝CHCH2H HHOH 4D83HCCCH2H HHOH 4D84CF3H HHOH 4D85PhO H HHOH 4D86PhS H HHOH 4D87PhSO H HHOH 4D88PhSO2H HHOH 4D89CH3CH3HHOH 4D90CH3CH2CH3HHOH 4D91CH3CH2CH2CH3HHOH 4D92(CH3)2CH CH3HHOH 4D93(CH3)3CCH3HHOH 4D94CH3SCH3HHOH 4D95CH3SO CH3HHOH 4D96CH3SO2CH3HHOH 4D97Ph CH3HHOH 4D98CH3OCH3HHOH 4基团R6R7R8R12R10oD99 CH2＝CHCH2CH3HHOH 4D100HCCCH2CH3HHOH 4D101CF3CH3HHOH 4D102PhO CH3HHOH 4D103PhS CH3HHOH 4D104PhSOCH3HHOH 4D105PhSO2CH3HHOH 4D106H H HCH3OH 4D107H H HCH3OH 3D108H H HHOH 1D109CH3H HHOH 1D110CH3OC(O) CH3HHOH 1D111CH3CH2OC(O) CH3HHOH 1D112CH3O CH3HHOH 1D113CH3S CH3HHOH 1D114CH3SO CH3HHOH 1D115CH3SO2CH3HHOH 1D116CH3CH2H HHOH 1D117CH3OC(O) CH3CH2HHOH 1D118CH3CH2OC(O) CH3CH2HHOH 1D119CH3O CH3CH2HHOH 1D120CH3S CH3CH2HHOH 1D121CH3SO CH3CH2HHOH 1D122CH3SO2CH3CH2HHOH 1D123CH3CH2S CH3HHOH 1D124CH3CH2SO CH3HHOH 1D125CH3CH2SO2CH3HHOH 1D126CH3CH2S CH3CH2HHOH 1D127CH3CH2SO CH3CH2HHOH 1D128CH3CH2SO2CH3CH2HHOH 1D129HH CH3HOH 1D130CH3H CH3HOH 1D131CH3OC(O) CH3CH3HOH 1基团R6R7R8R12R10oD132CH3CH2OC(O) CH3CH3HOH 1D133CH3O CH3CH3HOH 1D134CH3S CH3CH3HOH 1D135CH3SO CH3CH3HOH 1D136CH3SO2CH3CH3HOH 1D137HH H CH3OH 1D138CH3H H CH3OH 1D139HH CH3CH3OH 1D140CH3CH2OC(O) CH3H HOH 4下表5中，Q代表Q4 并且Q4代表下列基团E表5基团E基团R6R7R10X Y W qE1 HH OHS CH2CH22E2 CH3H OHS CH2CH22E3 CH3CH3OHS CH2CH22E4 CH3OC(O)H OHS CH2CH22E5 CH3CH3OC(O) OHS CH2CH22E6 HH OHSOCH2CH22E7 CH3H OHSOCH2CH22E8 CH3CH3OHSOCH2CH22E9 CH3OC(O)H OHSOCH2CH22E10 CH3CH3OC(O) OHSOCH2CH22E11 HH OHSO2CH2CH22基团 R6R7R10X YW qE12CH3H OHSO2CH2CH22E13CH3CH3OHSO2CH2CH22E14CH3OC(O)H OHSO2CH2CH22E15CH3CH3OC(O) OHSO2CH2CH22E16HH OHCO OCH22E17CH3H OHCO OCH22E18CH3CH3OHCO OCH22E19CH3OC(O)H OHCO OCH22E20CH3CH3OC(O) OHCO OCH22E21HHOHCO OCH22E22CH3H OHCO OCH22E23CH3CH3OHCO OCH22E24CH3OC(O)H OHCO OCH22E25CH3CH3OC(O) OHCO OCH22E26HHOHCO OCH22E27CH3H OHCO OCH22E28CH3CH3OHCO OCH22E29CH3OC(O)H OHCO OCH22E30CH3CH3OC(O) OHCO OCH22下表6中，Q代表Q5 并且Q5代表下列基团F表6基团F基团R6R7R8R10F1 H H H OHF2 CH3H H OH基团R6R7R8R10F3 CH3CH3H OHF4 CH3CH3CH3OHF5 H H CH3OHF6 H CH3CH3OH表7式Ia化合物 化合物序号R2R3R4R5Q1pA1H HHCF3B24 0A2CH3HHCF3B24 0A3CH3CH2HHCF3B24 0A4(CH3)2CH HHCF3B24 0A5(CH3)3C HHCF3B24 0A6环丙基 HHCF3B24 0A7CH3(CH2)2HHCF3B24 0A8CH3OCH2HHCF3B24 0A9CH3O(CH2)2HHCF3B24 0A10Ph HHCF3B24 0A11PhOHHCF3B24 0A12PhSHHCF3B24 0A13PhSO HHCF3B24 0A14PhSO2HHCF3B24 0A15CH3S HHCF3B24 0A16CH3SO HHCF3B24 0A17CF3HHCF3B24 0A18F2CH HHCF3B24 0化合物序号 R2R3R4R5Q1pA19 HCCHHCF3B24 0A20 CH3CC HHCF3B24 0A21 CH2＝CH HHCF3B24 0A22 CH2＝CHCH2HHCF3B24 0A23 CH3SO2N(CH3) HHCF3B24 0A24 (CH3)2N HHCF3B24 0A25 (CH3)2NSO2HHCF3B24 0A26 ClCH2HHCF3B24 0A27 CH3SCH2HHCF3B24 0A28 CH3SOCH2HHCF3B24 0A29 CH3SO2CH2HHCF3B24 0A30 [1.2.4]-三唑-1-基甲基 HHCF3B24 0A31 CH3CF3HCH3B24 0A32 CH3CH3HCF3B24 0A33 H HHCF3CF2B24 0A34 CH3HHCF3CF2B24 0A35 CH3CH2HHCF3CF2B24 0A36 环丙基 HHCF3CF2B24 0A37 (CH3)3C HHCF3CF2B24 0A38 (CH3)2CH HHCF3CF2B24 0A39 CH3(CH2)2HHCF3CF2B24 0A40 CH3OCH2HHCF3CF2B24 0A41 CH3O(CH2)2HHCF3CF2B24 0A42 Ph HHCF3CF2B24 0A43 PhO HHCF3CF2B24 0A44 PhS HHCF3CF2B24 0A45 PhSOHHCF3CF2B24 0A46 PhSO2HHCF3CF2B24 0A47 CH3S HHCF3CF2B24 0A48 CH3SO HHCF3CF2B24 0A49 CF3HHCF3CF2B24 0化合物序号 R2R3R4R5Q1pA50 F2CH HHCF3CF2B24 0A51 HCCHHCF3CF2B24 0A52 CH3CC HHCF3CF2B24 0A53 CH2＝CH HHCF3CF2B24 0A54 CH2＝CHCH2HHCF3CF2B24 0A55 CH3SO2N(CH3)HHCF3CF2B24 0A56 (CH3)2N HHCF3CF2B24 0A57 (CH3)2NSO2HHCF3CF2B24 0A58 ClCH2HHCF3CF2B24 0A59 CH3SCH2HHCF3CF2B24 0A60 CH3SOCH2HHCF3CF2B24 0A61 CH3SO2CH2HHCF3CF2B24 0A62 [1.2.4]-三唑-1-基甲基 HHCF3CF2B24 0A63 H HHCF3CF2CF2B24 0A64 CH3HHCF3CF2CF2B24 0A65 CH3CH2HHCF3CF2CF2B24 0A66 环丙基 HHCF3CF2CF2B24 0A67 (CH3)3C HHCF3CF2CF2B24 0A68 (CH3)2CH HHCF3CF2CF2B24 0A69 CH3(CH2)2HHCF3CF2CF2B24 0A70 CH3OCH2HHCF3CF2CF2B24 0A71 CH3O(CH2)2HHCF3CF2CF2B24 0A72 Ph HHCF3CF2CF2B24 0A73 PhOHHCF3CF2CF2B24 0A74 PhSHHCF3CF2CF2B24 0A75 PhSO HHCF3CF2CF2B24 0A76 PhSO2HHCF3CF2CF2B24 0A77 CH3S HHCF3CF2CF2B24 0A78 CH3SO HHCF3CF2CF2B24 0A79 CF3HHCF3CF2CF2B24 0A80 F2CH HHCF3CF2CF2B24 0化合物序号R2R3R4R5Q1pA81 HCC HHCF3CF2CF2B24 0A82 CH3CC HHCF3CF2CF2B24 0A83 CH2＝CH HHCF3CF2CF2B24 0A84 CH2＝CHCH2HHCF3CF2CF2B24 0A85 CH3SO2N(CH3) HHCF3CF2CF2B24 0A86 (CH3)2NHHCF3CF2CF2B24 0A87 (CH3)2NSO2HHCF3CF2CF2B24 0A88 ClCH2HHCF3CF2CF2B24 0A89 CH3SCH2HHCF3CF2CF2B24 0A90 CH3SOCH2HHCF3CF2CF2B24 0A91 CH3SO2CH2HHCF3CF2CF2B24 0A92 [1.2.4]-三唑-1-基甲基 HHCF3CF2CF2B24 0A93 H HHCF2ClB24 0A94 CH3HHCF2ClB24 0A95 CH3CH2HHCF2ClB24 0A96 环丙基 HHCF2ClB24 0A97 (CH3)3C HHCF2ClB24 0A98 (CH3)2CHHHCF2ClB24 0A99 CH3(CH2)2HHCF2ClB24 0A100 CH3OCH2HHCF2ClB24 0A101 CH3O(CH2)2HHCF2ClB24 0A102 Ph HHCF2ClB24 0A103 PhOHHCF2ClB24 0A104 PhSHHCF2ClB24 0A105 PhSO HHCF2ClB24 0A106 PhSO2HHCF2ClB24 0A107 CH3S HHCF2ClB24 0A108 CH3SO HHCF2ClB24 0A109 CF3HHCF2ClB24 0A110 F2CH HHCF2ClB24 0A111 HCCHHCF2ClB24 0化合物序号R2R3R4R5Q1pA112 CH3CC HHCF2Cl B24 0A113 CH2＝CH HHCF2Cl B24 0A114 CH2＝CHCH2HHCF2Cl B24 0A115 CH3SO2N(CH3) HHCF2Cl B24 0A116 (CH3)2NHHCF2Cl B24 0A117 (CH3)2NSO2HHCF2Cl B24 0A118 ClCH2HHCF2Cl B24 0A119 CH3SCH2HHCF2Cl B24 0A120 CH3SOCH2HHCF2Cl B24 0A121 CH3SO2CH2HHCF2Cl B24 0A122 [1.2.4]-三唑-1-基甲基 HHCF2Cl B24 0A123 H HHCHF2B24 0A124 CH3HHCHF2B24 0A125 CH3CH2HHCHF2B24 0A126 环丙基 HHCHF2B24 0A127 (CH3)3C HHCHF2B24 0A128 (CH3)2CHHHCHF2B24 0A129 CH3(CH2)2HHCHF2B24 0A130 CH3OCH2HHCHF2B24 0A131 CH3O(CH2)2HHCHF2B24 0A132 Ph HHCHF2B24 0A133 PhOHHCHF2B24 0A134 PhSHHCHF2B24 0A135 PhSO HHCHF2B24 0A136 PhSO2HHCHF2B24 0A137 CH3S HHCHF2B24 0A138 CH3SO HHCHF2B24 0A139 CF3HHCHF2B24 0A140 F2CH HHCHF2B24 0A141 HCCHHCHF2B24 0A142 CH3CC HHCHF2B24 0化合物序号R2R3R4R5Q1pA143 CH2＝CH HHCHF2B24 0A144 CH2＝CHCH2HHCHF2B24 0A145 CH3SO2N(CH3)HHCHF2B24 0A146 (CH3)2N HHCHF2B24 0A147 (CH3)2NSO2HHCHF2B24 0A148 ClCH2HHCHF2B24 0A149 CH3SCH2HHCHF2B24 0A150 CH3SOCH2HHCHF2B24 0A151 CH3SO2CH2HHCHF2B24 0A152 [1.2.4]-三唑-1-基甲基 HHCHF2B24 0A153 H HHCCl3B24 0A154 CH3HHCCl3B24 0A155 CH3CH2HHCCl3B24 0A156 环丙基 HHCCl3B24 0A157 (CH3)3C HHCCl3B24 0A158 (CH3)2CH HHCCl3B24 0A159 CH3(CH2)2HHCCl3B24 0A160 CH3OCH2HHCCl3B24 0A161 CH3O(CH2)2HHCCl3B24 0A162 Ph HHCCl3B24 0A163 PhO HHCCl3B24 0A164 PhS HHCCl3B24 0A165 PhSOHHCCl3B24 0A166 PhSO2HHCCl3B24 0A167 CH3S HHCCl3B24 0A168 CH3SO HHCCl3B24 0A169 CF3HHCCl3B24 0A170 F2CH HHCCl3B24 0A171 HCC HHCCl3B24 0A172 CH3CC HHCCl3B24 0A173 CH2＝CHHHCCl3B24 0化合物序号R2R3R4R5Q1pA174 CH2＝CHCH2HH CCl3B24 0A175 CH3SO2N(CH3) HH CCl3B24 0A176 (CH3)2N HH CCl3B24 0A177 (CH3)2NSO2HH CCl3B24 0A178 ClCH2HH CCl3B24 0A179 CH3SCH2HH CCl3B24 0A180 CH3SOCH2HH CCl3B24 0A181 CH3SO2CH2HH CCl3B24 0A182 [1.2.4]-三唑-1-基甲基 HH CCl3B24 0A183 H HCH3CF3B24 0A184 CH3HCH3CF3B24 0A185 CH3CH2HCH3CF3B24 0A186 环丙基 HCH3CF3B24 0A187 (CH3)3C HCH3CF3B24 0A188 (CH3)2CH HCH3CF3B24 0A189 CH3(CH2)2HCH3CF3B24 0A190 CH3OCH2HCH3CF3B24 0A191 CH3O(CH2)2HCH3CF3B24 0A192 Ph HCH3CF3B24 0A193 PhO HCH3CF3B24 0A194 PhS HCH3CF3B24 0A195 PhSOHCH3CF3B24 0A196 PhSO2HCH3CF3B24 0A197 CH3S HCH3CF3B24 0A198 CH3SO HCH3CF3B24 0A199 CF3HCH3CF3B24 0A200 F2CH HCH3CF3B24 0A201 HCC HCH3CF3B24 0A202 CH3CC HCH3CF3B24 0A203 CH2＝CHHCH3CF3B24 0A204 CH2＝CHCH2HCH3CF3B24 0化合物序号 R2R3R4R5Q1pNo.A205CH3SO2N(CH3) HCH3CF3B24 0A206(CH3)2N HCH3CF3B24 0A207(CH3)2NSO2HCH3CF3B24 0A208ClCH2HCH3CF3B24 0A209CH3SCH2HCH3CF3B24 0A210CH3SOCH2HCH3CF3B24 0A211CH3SO2CH2HCH3CF3B24 0A212H HCH3CF3CF2B24 0A213CH3HCH3CF3CF2B24 0A214CH3CH2HCH3CF3CF2B24 0A215环丙基 HCH3CF3CF2B24 0A216(CH3)3C HCH3CF3CF2B24 0A217(CH3)2CHHCH3CF3CF2B24 0A218CH3(CH2)2HCH3CF3CF2B24 0A219CH3OCH2HCH3CF3CF2B24 0A220CH3O(CH2)2HCH3CF3CF2B24 0A221Ph HCH3CF3CF2B24 0A222PhOHCH3CF3CF2B24 0A223PhSHCH3CF3CF2B24 0A224PhSO HCH3CF3CF2B24 0A225PhSO2HCH3CF3CF2B24 0A226CH3S HCH3CF3CF2B24 0A227CH3SO HCH3CF3CF2B24 0A228CF3HCH3CF3CF2B24 0A229F2CH HCH3CF3CF2B24 0A230HCCHCH3CF3CF2B24 0A231CH3CC HCH3CF3CF2B24 0A232CH2＝CH HCH3CF3CF2B24 0A233CH2＝CHCH2HCH3CF3CF2B24 0A234CH3SO2N(CH3)HCH3CF3CF2B24 0A235(CH3)2N HCH3CF3CF2B24 0A236(CH3)2NSO2HCH3CF3CF2B24 0化合物序号 R2R3R4R5Q1pA237ClCH2HCH3CF3CF2B24 0A238CH3SCH2HCH3CF3CF2B24 0A239CH3SOCH2HCH3CF3CF2B24 0A240CH3SO2CH2HCH3CF3CF2B24 0A241H HCH3CF3CF2CF2B24 0A242CH3HCH3CF3CF2CF2B24 0A243CH3CH2HCH3CF3CF2CF2B24 0A244环丙基 HCH3CF3CF2CF2B24 0A245(CH3)3C HCH3CF3CF2CF2B24 0A246(CH3)2CH HCH3CF3CF2CF2B24 0A247CH3(CH2)2HCH3CF3CF2CF2B24 0A248CH3OCH2HCH3CF3CF2CF2B24 0A249CH3O(CH2)2HCH3CF3CF2CF2B24 0A250Ph HCH3CF3CF2CF2B24 0A251PhO HCH3CF3CF2CF2B24 0A252PhS HCH3CF3CF2CF2B24 0A253PhSOHCH3CF3CF2CF2B24 0A254PhSO2HCH3CF3CF2CF2B24 0A255CH3S HCH3CF3CF2CF2B24 0A256CH3SO HCH3CF3CF2CF2B24 0A257CF3HCH3CF3CF2CF2B24 0A258F2CH HCH3CF3CF2CF2B24 0A259HCC HCH3CF3CF2CF2B24 0A260CH3CC HCH3CF3CF2CF2B24 0A261CH2＝CHHCH3CF3CF2CF2B24 0A262CH2＝CHCH2HCH3CF3CF2CF2B24 0A263CH3SO2N(CH3) HCH3CF3CF2CF2B24 0A264(CH3)2N HCH3CF3CF2CF2B24 0A265(CH3)2NSO2HCH3CF3CF2CF2B24 0A266ClCH2HCH3CF3CF2CF2B24 0A267CH3SCH2HCH3CF3CF2CF2B24 0A268CH3SOCH2HCH3CF3CF2CF2B24 0化合物序号 R2R3R4R5Q1pA269CH3SO2CH2HCH3CF3CF2CF2B24 0A270H HCH3CF2Cl B24 0A271CH3HCH3CF2Cl B24 0A272CH3CH2HCH3CF2Cl B24 0A273环丙基 HCH3CF2Cl B24 0A274(CH3)3C HCH3CF2Cl B24 0A275(CH3)2CHHCH3CF2Cl B24 0A276CH3(CH2)2HCH3CF2Cl B24 0A277CH3OCH2HCH3CF2Cl B24 0A278CH3O(CH2)2HCH3CF2Cl B24 0A279Ph HCH3CF2Cl B24 0A280PhOHCH3CF2Cl B24 0A281PhSHCH3CF2Cl B24 0A282PhSO HCH3CF2Cl B24 0A283PhSO2HCH3CF2Cl B24 0A284CH3S HCH3CF2Cl B24 0A285CH3SO HCH3CF2Cl B24 0A286CF3HCH3CF2Cl B24 0A287F2CH HCH3CF2Cl B24 0A288HCCHCH3CF2Cl B24 0A289CH3CC HCH3CF2Cl B24 0A290CH2＝CH HCH3CF2Cl B24 0A291CH2＝CHCH2HCH3CF2Cl B24 0A292CH3SO2N(CH3)HCH3CF2Cl B24 0A293(CH3)2N HCH3CF2Cl B24 0A294(CH3)2NSO2HCH3CF2Cl B24 0A295ClCH2HCH3CF2Cl B24 0A296CH3SCH2HCH3CF2Cl B24 0A297CH3SOCH2HCH3CF2Cl B24 0A298CH3SO2CH2HCH3CF2Cl B24 0A299H HCH3CHF2B24 0A300CH3HCH3CHF2B24 0化合物序号 R2R3R4R5Q1pA301CH3CH2HCH3CHF2B24 0A302环丙基HCH3CHF2B24 0A303(CH3)3CHCH3CHF2B24 0A304(CH3)2CH HCH3CHF2B24 0A305CH3(CH2)2HCH3CHF2B24 0A306CH3OCH2HCH3CHF2B24 0A307CH3O(CH2)2HCH3CHF2B24 0A308PhHCH3CHF2B24 0A309PhO HCH3CHF2B24 0A310PhS HCH3CHF2B24 0A311PhSO HCH3CHF2B24 0A312PhSO2HCH3CHF2B24 0A313CH3S HCH3CHF2B24 0A314CH3SOHCH3CHF2B24 0A315CF3HCH3CHF2B24 0A316F2CH HCH3CHF2B24 0A317HCC HCH3CHF2B24 0A318CH3CCHCH3CHF2B24 0A319CH2＝CH HCH3CHF2B24 0A320CH2＝CHCH2HCH3CHF2B24 0A321CH3SO2N(CH3) HCH3CHF2B24 0A322(CH3)2N HCH3CHF2B24 0A323(CH3)2NSO2HCH3CHF2B24 0A324ClCH2HCH3CHF2B24 0A325CH3SCH2HCH3CHF2B24 0A326CH3SOCH2HCH3CHF2B24 0A327CH3SO2CH2HCH3CHF2B24 0A328H HCH3CCl3B24 0A329CH3HCH3CCl3B24 0A330CH3CH2HCH3CCl3B24 0A331(CH3)3C HCH3CCl3B24 0A332(CH3)2CHHCH3CCl3B24 0化合物序号 R2R3R4R5Q1pA333环丙基 HCH3CCl3B24 0A334CH3(CH2)2HCH3CCl3B24 0A335CH3OCH2HCH3CCl3B24 0A336CH3O(CH2)2HCH3CCl3B24 0A337Ph HCH3CCl3B24 0A338PhO HCH3CCl3B24 0A339PhS HCH3CCl3B24 0A340PhSOHCH3CCl3B24 0A341PhSO2HCH3CCl3B24 0A342CH3S HCH3CCl3B24 0A343CH3SO HCH3CCl3B24 0A344CF3HCH3CCl3B24 0A345F2CH HCH3CCl3B24 0A346HCC HCH3CCl3B24 0A347CH3CC HCH3CCl3B24 0A348CH2＝CHHCH3CCl3B24 0A349CH2＝CHCH2HCH3CCl3B24 0A350CH3SO2N(CH3) HCH3CCl3B24 0A351(CH3)2N HCH3CCl3B24 0A352(CH3)2NSO2HCH3CCl3B24 0A353ClCH2HCH3CCl3B24 0A354CH3SCH2HCH3CCl3B24 0A355CH3SOCH2HCH3CCl3B24 0A356CH3SO2CH2HCH3CCl3B24 0A357HHPh CF3B24 0A358CH3HPh CF3B24 0A359CH3CH2HPh CF3B24 0A360环丙基 HPh CF3B24 0A361(CH3)3C HPh CF3B24 0A362(CH3)2CH HPh CF3B24 0A363CH3(CH2)2HPh CF3B24 0A364CH3OCH2HPh CF3B24 0化合物序号 R2R3R4R5Q1pA365CH3O(CH2)2HPhCF3B24 0A366PhHPhCF3B24 0A367PhO HPhCF3B24 0A368PhS HPhCF3B24 0A369PhSO HPhCF3B24 0A370PhSO2HPhCF3B24 0A371CH3S HPhCF3B24 0A372CH3SOHPhCF3B24 0A373CF3HPhCF3B24 0A374F2CH HPhCF3B24 0A375HCC HPhCF3B24 0A376CH3CCHPhCF3B24 0A377CH2＝CH HPhCF3B24 0A378CH2＝CHCH2HPhCF3B24 0A379CH3SO2N(CH3) HPhCF3B24 0A380(CH3)2N HPhCF3B24 0A381(CH3)2NSO2HPhCF3B24 0A382ClCH2HPhCF3B24 0A383CH3SCH2HPhCF3B24 0A384CH3SOCH2HPhCF3B24 0A385CH3SO2CH2HPhCF3B24 0A386H HPhCF3CF2B24 0A387CH3HPhCF3CF2B24 0A388CH3CH2HPhCF3CF2B24 0A389环丙基 HPhCF3CF2B24 0A390(CH3)3C HPhCF3CF2B24 0A391(CH3)2CHHPhCF3CF2B24 0A392CH3(CH2)2HPhCF3CF2B24 0A393CH3OCH2HPhCF3CF2B24 0A394CH3O(CH2)2HPhCF3CF2B24 0A395Ph HPhCF3CF2B24 0A396PhOHPhCF3CF2B24 0化合物序号 R2R3R4R5Q1pA397PhS HPhCF3CF2B24 0A398PhSO HPhCF3CF2B24 0A399PhSO2HPhCF3CF2B24 0A400CH3S HPhCF3CF2B24 0A401CH3SOHPhCF3CF2B24 0A402CF3HPhCF3CF2B24 0A403F2CH HPhCF3CF2B24 0A404HCC HPhCF3CF2B24 0A405CH3CCHPhCF3CF2B24 0A406CH2＝CH HPhCF3CF2B24 0A407CH2＝CHCH2HPhCF3CF2B24 0A408CH3SO2N(CH3) HPhCF3CF2B24 0A409(CH3)2N HPhCF3CF2B24 0A410(CH3)2NSO2HPhCF3CF2B24 0A411ClCH2HPhCF3CF2B24 0A412CH3SCH2HPhCF3CF2B24 0A413CH3SOCH2HPhCF3CF2B24 0A414CH3SO2CH2HPhCF3CF2B24 0A415H HPhCF3CF2CF2B24 0A416CH3HPhCF3CF2CF2B24 0A417CH3CH2HPhCF3CF2CF2B24 0A418环丙基 HPhCF3CF2CF2B24 0A419(CH3)3C HPhCF3CF2CF2B24 0A420(CH3)2CHHPhCF3CF2CF2B24 0A421CH3(CH2)2HPhCF3CF2CF2B24 0A422CH3OCH2HPhCF3CF2CF2B24 0A423CH3O(CH2)2HPhCF3CF2CF2B24 0A424Ph HPhCF3CF2CF2B24 0A425PhOHPhCF3CF2CF2B24 0A426PhSHPhCF3CF2CF2B24 0A427PhSO HPhCF3CF2CF2B24 0A428PhSO2HPhCF3CF2CF2B24 0化合物序号 R2R3R4R5Q1pA429CH3S HPhCF3CF2CF2B24 0A430CH3SOHPhCF3CF2CF2B24 0A431CF3HPhCF3CF2CF2B24 0A432F2CH HPhCF3CF2CF2B24 0A433HCC HPhCF3CF2CF2B24 0A434CH3CCHPhCF3CF2CF2B24 0A435CH2＝CH HPhCF3CF2CF2B24 0A436CH2＝CHCH2HPhCF3CF2CF2B24 0A437CH3SO2N(CH3) HPhCF3CF2CF2B24 0A438(CH3)2N HPhCF3CF2CF2B24 0A439(CH3)2NSO2HPhCF3CF2CF2B24 0A440ClCH2HPhCF3CF2CF2B24 0A441CH3SCH2HPhCF3CF2CF2B24 0A442CH3SOCH2HPhCF3CF2CF2B24 0A443CH3SO2CH2HPhCF3CF2CF2B24 0A444H HPhCF2Cl B24 0A445CH3HPhCF2Cl B24 0A446CH3CH2HPhCF2Cl B24 0A447环丙基 HPhCF2Cl B24 0A448(CH3)3C HPhCF2Cl B24 0A449(CH3)2CHHPhCF2Cl B24 0A450CH3(CH2)2HPhCF2Cl B24 0A451CH3OCH2HPhCF2Cl B24 0A452CH3O(CH2)2HPhCF2Cl B24 0A453Ph HPhCF2Cl B24 0A454PhOHPhCF2Cl B24 0A455PhSHPhCF2Cl B24 0A456PhSO HPhCF2Cl B24 0A457PhSO2HPhCF2Cl B24 0A458CH3S HPhCF2Cl B24 0A459CH3SO HPhCF2Cl B24 0A460CF3HPhCF2Cl B24 0化合物序号 R2R3R4R5Q1pA461F2CH HPhCF2ClB24 0A462HCC HPhCF2ClB24 0A463CH3CCHPhCF2ClB24 0A464CH2＝CH HPhCF2ClB24 0A465CH2＝CHCH2HPhCF2ClB24 0A466CH3SO2N(CH3) HPhCF2ClB24 0A467(CH3)2N HPhCF2ClB24 0A468(CH3)2NSO2HPhCF2ClB24 0A469ClCH2HPhCF2ClB24 0A470CH3SCH2HPhCF2ClB24 0A471CH3SOCH2HPhCF2ClB24 0A472CH3SO2CH2HPhCF2ClB24 0A473H HPhCHF2B24 0A474CH3HPhCHF2B24 0A475CH3CH2HPhCHF2B24 0A476环丙基 HPhCHF2B24 0A477(CH3)3C HPhCHF2B24 0A478(CH3)2CHHPhCHF2B24 0A479CH3(CH2)2HPhCHF2B24 0A480CH3OCH2HPhCHF2B24 0A481CH3O(CH2)2HPhCHF2B24 0A482Ph HPhCHF2B24 0A483PhOHPhCHF2B24 0A484PhSHPhCHF2B24 0A485PhSO HPhCHF2B24 0A486PhSO2HPhCHF2B24 0A487CH3S HPhCHF2B24 0A488CH3SO HPhCHF2B24 0A489CF3HPhCHF2B24 0A490F2CH HPhCHF2B24 0A491HCCHPhCHF2B24 0A492CH3CC HPhCHF2B24 0化合物序号 R2R3R4R5Q1pA493CH2＝CH HPhCHF2B24 0A494CH2＝CHCH2HPhCHF2B24 0A495CH3SO2N(CH3) HPhCHF2B24 0A496(CH3)2N HPhCHF2B24 0A497(CH3)2NSO2HPhCHF2B24 0A498ClCH2HPhCHF2B24 0A499CH3SCH2HPhCHF2B24 0A500CH3SOCH2HPhCHF2B24 0A501CH3SO2CH2HPhCHF2B24 0A502H HPhCCl3B24 0A503CH3HPhCCl3B24 0A504CH3CH2HPhCCl3B24 0A505环丙基 HPhCCl3B24 0A506(CH3)3C HPhCCl3B24 0A507(CH3)2CHHPhCCl3B24 0A508CH3(CH2)2HPhCCl3B24 0A509CH3OCH2HPhCCl3B24 0A510CH3O(CH2)2HPhCCl3B24 0A511Ph HPhCCl3B24 0A512PhOHPhCCl3B24 0A513PhSHPhCCl3B24 0A514PhSO HPhCCl3B24 0A515PhSO2HPhCCl3B24 0A516CH3S HPhCCl3B24 0A517CH3SO HPhCCl3B24 0A518CF3HPhCCl3B24 0A519F2CH HPhCCl3B24 0A520HCCHPhCCl3B24 0A521CH3CC HPhCCl3B24 0A522CH2＝CH HPhCCl3B24 0A523CH2＝CHCH2HPhCCl3B24 0A524CH3SO2N(CH3)HPhCCl3B24 0化合物序号 R2R3R4R5Q1pA525(CH3)2N H Ph CCl3B24 0A526(CH3)2NSO2H Ph CCl3B24 0A527ClCH2H Ph CCl3B24 0A528CH3SCH2H Ph CCl3B24 0A529CH3SOCH2H Ph CCl3B24 0A530CH3SO2CH2H Ph CCl3B24 0A531H CH3HCF3B24 0A532H CH3CH2HCF3B24 0A533H 环丙基 HCF3B24 0A534H (CH3)3CH HCF3B24 0A535H (CH3)2CH HCF3B24 0A536H CH3(CH2)2HCF3B24 0A537H CH3OCH2HCF3B24 0A538H CH3O(CH2)2HCF3B24 0A539H Ph HCF3B24 0A540H PhO HCF3B24 0A541H PhS HCF3B24 0A542H PhSOHCF3B24 0A543H PhSO2HCF3B24 0A544H CH3S HCF3B24 0A545H CH3SO HCF3B24 0A546H CF3HCF3B24 0A547H F2CHHCF3B24 0A548H HCC HCF3B24 0A549H CH3CC HCF3B24 0A550H CH2＝CHHCF3B24 0A551H CH2＝CHCH2HCF3B24 0A552H CH3SO2N(CH3) HCF3B24 0A553H (CH3)2N HCF3B24 0A554H (CH3)2NSO2HCF3B24 0A555H CH3SCH2HCF3B24 0A556H CH3SOCH2HCF3B24 0化合物序号 R2R3R4R5Q1pA557HCH3SO2CH2HCF3B24 0A558HCH3HCF3CF2B24 0A559HCH3CH2HCF3CF2B24 0A560H环丙基 HCF3CF2B24 0A561H(CH3)3C HCF3CF2B24 0A562H(CH3)2CH HCF3CF2B24 0A563HCH3(CH2)2HCF3CF2B24 0A564HCH3OCH2HCF3CF2B24 0A565HCH3O(CH2)2HCF3CF2B24 0A566HPh HCF3CF2B24 0A567HPhO HCF3CF2B24 0A568HPhS HCF3CF2B24 0A569HPhSOHCF3CF2B24 0A570HPhSO2HCF3CF2B24 0A571HCH3S HCF3CF2B24 0A572HCH3SO HCF3CF2B24 0A573HCF3HCF3CF2B24 0A574HF2CH HCF3CF2B24 0A575HHCC HCF3CF2B24 0A576HCH3CC HCF3CF2B24 0A577HCH2＝CHHCF3CF2B24 0A578HCH2＝CHCH2HCF3CF2B24 0A579HCH3SO2N(CH3) HCF3CF2B24 0A580H(CH3)2N HCF3CF2B24 0A581H(CH3)2NSO2HCF3CF2B24 0A582HCH3SCH2HCF3CF2B24 0A583HCH3SOCH2HCF3CF2B24 0A584HCH3SO2CH2HCF3CF2B24 0A585HCH3HCF3CF2CF2B24 0A586HCH3CH2HCF3CF2CF2B24 0A587H环丙基 HCF3CF2CF2B24 0A588H(CH3)3C HCF3CF2CF2B24 0化合物序号 R2R3R4R5Q1pA589H(CH3)2CH HCF3CF2CF2B24 0A590HCH3(CH2)2HCF3CF2CF2B24 0A591HCH3OCH2HCF3CF2CF2B24 0A592HCH3O(CH2)2HCF3CF2CF2B24 0A593HPhHCF3CF2CF2B24 0A594HPhO HCF3CF2CF2B24 0A595HPhS HCF3CF2CF2B24 0A596HPhSO HCF3CF2CF2B24 0A597HPhSO2HCF3CF2CF2B24 0A598HCH3S HCF3CF2CF2B24 0A599HCH3SOHCF3CF2CF2B24 0A600HCF3HCF3CF2CF2B24 0A601HF2CH HCF3CF2CF2B24 0A602HHCC HCF3CF2CF2B24 0A603HCH3CCHCF3CF2CF2B24 0A604HCH2＝CH HCF3CF2CF2B24 0A605HCH2＝CHCH2HCF3CF2CF2B24 0A606HCH3SO2N(CH3) HCF3CF2CF2B24 0A607H(CH3)2N HCF3CF2CF2B24 0A608H(CH3)2NSO2HCF3CF2CF2B24 0A609HCH3SCH2HCF3CF2CF2B24 0A610HCH3SOCH2HCF3CF2CF2B24 0A611HCH3SO2CH2HCF3CF2CF2B24 0A612HCH3HCF2Cl B24 0A613HCH3CH2HCF2Cl B24 0A614H环丙基 HCF2Cl B24 0A615H(CH3)3C HCF2Cl B24 0A616H(CH3)2CH HCF2Cl B24 0A617HCH3(CH2)2HCF2Cl B24 0A618HCH3OCH2HCF2Cl B24 0A619HCH3O(CH2)2HCF2Cl B24 0A620HPh HCF2Cl B24 0化合物 R2R3R4R5Q1pA621HPhO HCF2ClB24 0A622HPhS HCF2ClB24 0A623HPhSO HCF2ClB24 0A624HPhSO2HCF2ClB24 0A625HCH3S HCF2ClB24 0A626HCH3SOHCF2ClB24 0A627HCF3HCF2ClB24 0A628HF2CH HCF2ClB24 0A629HHCC HCF2ClB24 0A630HCH3CCHCF2ClB24 0A631HCH2＝CH HCF2ClB24 0A632HCH2＝CHCH2HCF2ClB24 0A633HCH3SO2N(CH3) HCF2ClB24 0A634H(CH3)2N HCF2ClB24 0A635H(CH3)2NSO2HCF2ClB24 0A636HCH3SCH2HCF2ClB24 0A637HCH3SOCH2HCF2ClB24 0A638HCH3SO2CH2HCF2ClB24 0A639HCH3HCHF2B24 0A640HCH3CH2HCHF2B24 0A641H环丙基 HCHF2B24 0A642H(CH3)3C HCHF2B24 0A643H(CH3)2CHHCHF2B24 0A644HCH3(CH2)2HCHF2B24 0A645HCH3OCH2HCHF2B24 0A646HCH3O(CH2)2HCHF2B24 0A647HPh HCHF2B24 0A648HPhOHCHF2B24 0A649HPhSHCHF2B24 0A650HPhSO HCHF2B24 0A651HPhSO2HCHF2B24 0A652HCH3S HCHF2B24 0化合物序号 R2R3R4R5Q1pA653HCH3SO HCHF2B24 0A654HCF3HCHF2B24 0A655HF2CHHCHF2B24 0A656HHCC HCHF2B24 0A657HCH3CC HCHF2B24 0A658HCH2＝CH HCHF2B24 0A659HCH2＝CHCH2HCHF2B24 0A660HCH3SO2N(CH3) HCHF2B24 0A661H(CH3)2NHCHF2B24 0A662H(CH3)2NSO2HCHF2B24 0A663HCH3SCH2HCHF2B24 0A664HCH3SOCH2HCHF2B24 0A665HCH3SO2CH2HCHF2B24 0A666HCH3HCCl3B24 0A667HCH3CH2HCCl3B24 0A668H环丙基HCCl3B24 0A669H(CH3)3CHCCl3B24 0A670H(CH3)2CH HCCl3B24 0A671HCH3(CH2)2HCCl3B24 0A672HCH3OCH2HCCl3B24 0A673HCH3O(CH2)2HCCl3B24 0A674HPhHCCl3B24 0A675HPhO HCCl3B24 0A676HPhS HCCl3B24 0A677HPhSO HCCl3B24 0A678HPhSO2HCCl3B24 0A679HCH3S HCCl3B24 0A680HCH3SOHCCl3B24 0A681HCF3HCCl3B24 0A682HF2CH HCCl3B24 0A683HHCC HCCl3B24 0A684HCH3CCHCCl3B24 0化合物序号 R2R3R4R5Q1pA685HCH2＝CHH CCl3B24 0A686HCH2＝CHCH2H CCl3B24 0A687HCH3SO2N(CH3) H CCl3B24 0A688H(CH3)2N H CCl3B24 0A689H(CH3)2NSO2H CCl3B24 0A690HCH3SCH2H CCl3B24 0A691HCH3SOCH2H CCl3B24 0A692HCH3SO2CH2H CCl3B24 0A693HCH3CH3CF3B24 0A694HCH3CH2CH3CF3B24 0A695H环丙基 CH3CF3B24 0A696H(CH3)3C CH3CF3B24 0A697H(CH3)2CH CH3CF3B24 0A698HCH3(CH2)2CH3CF3B24 0A699HCH3OCH2CH3CF3B24 0A700HCH3O(CH2)2CH3CF3B24 0A701HPh CH3CF3B24 0A702HPhO CH3CF3B24 0A703HPhS CH3CF3B24 0A704HPhSO CH3CF3B24 0A705HPhSO2CH3CF3B24 0A706HCH3SCH3CF3B24 0A707HCH3SO CH3CF3B24 0A708HCF3CH3CF3B24 0A709HF2CHCH3CF3B24 0A710HHCC CH3CF3B24 0A711HCH3CC CH3CF3B24 0A712HCH2＝CH CH3CF3B24 0A713HCH2＝CHCH2CH3CF3B24 0A714HCH3SO2N(CH3) CH3CF3B24 0A715H(CH3)2NCH3CF3B24 0A716H(CH3)2NSO2CH3CF3B24 0化合物序号 R2R3R4R5Q1pA717HCH3SCH2CH3CF3B24 0A718HCH3SOCH2CH3CF3B24 0A719HCH3SO2CH2CH3CF3B24 0A720HCH3CH3CF3CF2B24 0A721HCH3CH2CH3CF3CF2B24 0A722H环丙基 CH3CF3CF2B24 0A723H(CH3)3C CH3CF3CF2B24 0A724H(CH3)2CHCH3CF3CF2B24 0A725HCH3(CH2)2CH3CF3CF2B24 0A726HCH3OCH2CH3CF3CF2B24 0A727HCH3O(CH2)2CH3CF3CF2B24 0A728HPh CH3CF3CF2B24 0A729HPhOCH3CF3CF2B24 0A730HPhSCH3CF3CF2B24 0A731HPhSO CH3CF3CF2B24 0A732HPhSO2CH3CF3CF2B24 0A733HCH3S CH3CF3CF2B24 0A734HCH3SO CH3CF3CF2B24 0A735HCF3CH3CF3CF2B24 0A736HF2CH CH3CF3CF2B24 0A737HHCCCH3CF3CF2B24 0A738HCH3CC CH3CF3CF2B24 0A739HCH2＝CH CH3CF3CF2B24 0A740HCH2＝CHCH2CH3CF3CF2B24 0A741HCH3SO2N(CH3)CH3CF3CF2B24 0A742H(CH3)2N CH3CF3CF2B24 0A743H(CH3)2NO2CH3CF3CF2B24 0A744HCH3SCH2CH3CF3CF2B24 0A745HCH3SOCH2CH3CF3CF2B24 0A746HCH3SO2CH2CH3CF3CF2B24 0A747HCH3CH3CF3CF2CF2B24 0A748HCH3CH2CH3CF3CF2CF2B24 0化合物序号 R2R3R4R5Q1pNo.A749H环丙基 CH3CF3CF2CF2B24 0A750H(CH3)3C CH3CF3CF2CF2B24 0A751H(CH3)2CHCH3CF3CF2CF2B24 0A752HCH3(CH2)2CH3CF3CF2CF2B24 0A753HCH3OCH2CH3CF3CF2CF2B24 0A754HCH3O(CH2)2CH3CF3CF2CF2B24 0A755HPh CH3CF3CF2CF2B24 0A756HPhOCH3CF3CF2CF2B24 0A757HPhSCH3CF3CF2CF2B24 0A758HPhSO CH3CF3CF2CF2B24 0A759HPhSO2CH3CF3CF2CF2B24 0A760HCH3S CH3CF3CF2CF2B24 0A761HCH3SO CH3CF3CF2CF2B24 0A762HCF3CH3CF3CF2CF2B24 0A763HF2CH CH3CF3CF2CF2B24 0A764HHCCCH3CF3CF2CF2B24 0A765HCH3CC CH3CF3CF2CF2B24 0A766HCH2＝CH CH3CF3CF2CF2B24 0A767HCH2＝CHCH2CH3CF3CF2CF2B24 0A768HCH3SO2N(CH3)CH3CF3CF2CF2B24 0A769H(CH3)2N CH3CF3CF2CF2B24 0A770H(CH3)2NSO2CH3CF3CF2CF2B24 0A771HCH3SCH2CH3CF3CF2CF2B24 0A772HCH3SOCH2CH3CF3CF2CF2B24 0A773HCH3SO2CH2CH3CF3CF2CF2B24 0A774HCH3CH3CF2Cl B24 0A775HCH3CH2CH3CF2Cl B24 0A776H环丙基 CH3CF2Cl B24 0A777H(CH3)3C CH3CF2Cl B24 0A778H(CH3)2CH CH3CF2Cl B24 0A779HCH3(CH2)2CH3CF2Cl B24 0A780HCH3OCH2CH3CF2Cl B24 0化合物序号 R2R3R4R5Q1pA781HCH3O(CH2)2CH3CF2ClB24 0A782HPh CH3CF2ClB24 0A783HPhO CH3CF2ClB24 0A784HPhS CH3CF2ClB24 0A785HPhSOCH3CF2ClB24 0A786HPhSO2CH3CF2ClB24 0A787HCH3S CH3CF2ClB24 0A788HCH3SO CH3CF2ClB24 0A789HCF3CH3CF2ClB24 0A790HF2CH CH3CF2ClB24 0A791HHCC CH3CF2ClB24 0A792HCH3CC CH3CF2ClB24 0A793HCH2＝CHCH3CF2ClB24 0A794HCH2＝CHCH2CH3CF2ClB24 0A795HCH3SO2N(CH3) CH3CF2ClB24 0A796H(CH3)2N CH3CF2ClB24 0A797H(CH3)2NSO2CH3CF2ClB24 0A798HCH3SCH2CH3CF2ClB24 0A799HCH3SOCH2CH3CF2ClB24 0A800HCH3SO2CH2CH3CF2ClB24 0A801HCH3CH3CHF2B24 0A802HCH3CH2CH3CHF2B24 0A803H环丙基 CH3CHF2B24 0A804H(CH3)3C CH3CHF2B24 0A805H(CH3)2CH CH3CHF2B24 0A806HCH3(CH2)2CH3CHF2B24 0A807HCH3OCH2CH3CHF2B24 0A808HCH3O(CH2)2CH3CHF2B24 0A809HPh CH3CHF2B24 0A810HPhO CH3CHF2B24 0A811HPhS CH3CHF2B24 0A812HPhSO CH3CHF2B24 0化合物序号 R2R3R4R5Q1pA813 HPhSO2CH3CHF2B24 0A814 HCH3S CH3CHF2B24 0A815 HCH3SOCH3CHF2B24 0A816 HCF3CH3CHF2B24 0A817 HF2CH CH3CHF2B24 0A818 HHCC CH3CHF2B24 0A819 HCH3CCCH3CHF2B24 0A820 HCH2＝CH CH3CHF2B24 0A821 HCH2＝CHCH2CH3CHF2B24 0A822 HCH3SO2N(CH3) CH3CHF2B24 0A823 H(CH3)2N CH3CHF2B24 0A824 H(CH3)2NSO2CH3CHF2B24 0A825 HCH3SCH2CH3CHF2B24 0A826 HCH3SOCH2CH3CHF2B24 0A827 HCH3SO2CH2CH3CHF2B24 0A828 HCH3CH3CCl3B24 0A829 HCH3CH2CH3CCl3B24 0A830 H环丙基 CH3CCl3B24 0A831 H(CH3)3C CH3CCl3B24 0A832 H(CH3)2CHCH3CCl3B24 0A833 HCH3(CH2)2CH3CCl3B24 0A834 HCH3OCH2CH3CCl3B24 0A835 HCH3O(CH2)2CH3CCl3B24 0A836 HPh CH3CCl3B24 0A837 HPhOCH3CCl3B24 0A838 HPhSCH3CCl3B24 0A839 HPhSO CH3CCl3B24 0A840 HPhSO2CH3CCl3B24 0A841 HCH3S CH3CCl3B24 0A842 HCH3SO CH3CCl3B24 0A843 HCF3CH3CCl3B24 0A844 HF2CH CH3CCl3B24 0化合物序号 R2R3R4R5Q1pA845 HHCC CH3CCl3B24 0A846 HCH3CC CH3CCl3B24 0A847 HCH2＝CHCH3CCl3B24 0A848 HCH2＝CHCH2CH3CCl3B24 0A849 HCH3SO2N(CH3) CH3CCl3B24 0A850 H(CH3)2N CH3CCl3B24 0A851 H(CH3)2NSO2CH3CCl3B24 0A852 HCH3SCH2CH3CCl3B24 0A853 HCH3SOCH2CH3CCl3B24 0A854 HCH3SO2CH2CH3CCl3B24 0A855 HCH3Ph CF3B24 0A856 HCH3CH2Ph CF3B24 0A857 H(CH3)2CH Ph CF3B24 0A858 H(CH3)2CH Ph CF3B24 0A859 H环丙基 Ph CF3B24 0A860 HCH3(CH2)2Ph CF3B24 0A861 HCH3OCH2Ph CF3B24 0A862 HCH3O(CH2)2Ph CF3B24 0A863 HPh Ph CF3B24 0A864 HPhO Ph CF3B24 0A865 HPhS Ph CF3B24 0A866 HPhSO Ph CF3B24 0A867 HPhSO2Ph CF3B24 0A868 HCH3SPh CF3B24 0A869 HCH3SO Ph CF3B24 0A870 HCF3Ph CF3B24 0A871 HF2CHPh CF3B24 0A872 HHCC Ph CF3B24 0A873 HCH3CC Ph CF3B24 0A874 HCH2＝CH Ph CF3B24 0A875 HCH2＝CHCH2Ph CF3B24 0A876 HCH3SO2N(CH3) Ph CF3B24 0化合物序号 R2R3R4R5Q1pA877H(CH3)2N PhCF3B24 0A878H(CH3)2NSO2PhCF3B24 0A879HCH3SCH2PhCF3B24 0A880HCH3SOCH2PhCF3B24 0A881HCH3SO2CH2PhCF3B24 0A882HCH3PhCF3CF2B24 0A883HCH3CH2PhCF3CF2B24 0A884H环丙基 PhCF3CF2B24 0A885H(CH3)3C PhCF3CF2B24 OA886H(CH3)2CH PhCF3CF2B24 0A887HCH3(CH2)2PhCF3CF2B24 0A888HCH3OCH2PhCF3CF2B24 0A889HCH3O(CH2)2PhCF3CF2B24 0A890HPh PhCF3CF2B24 0A891HPhO PhCF3CF2B24 0A892HPhS PhCF3CF2B24 0A893HPhSOPhCF3CF2B24 0A894HPhSO2PhCF3CF2B24 0A895HCH3S PhCF3CF2B24 0A896HCH3SO PhCF3CF2B24 0A897HCF3PhCF3CF2B24 0A898HF2CH PhCF3CF2B24 0A899HHCC PhCF3CF2B24 0A900HCH3CC PhCF3CF2B24 0A901HCH2＝CHPhCF3CF2B24 0A902HCH2＝CHCH2PhCF3CF2B24 0A903HCH3SO2N(CH3) PhCF3CF2B24 0A904H(CH3)2N PhCF3CF2B24 0A905H(CH3)2NSO2PhCF3CF2B24 0A906HCH3SCH2PhCF3CF2B24 0A907HCH3SOCH2PhCF3CF2B24 0A908HCH3SO2CH2PhCF3CF2B24 0化合物序号 R2R3R4R5Q1pA909HCH3PhCF3CF2CF2B24 0A910HCH3CH2PhCF3CF2CF2B24 0A911H环丙基 PhCF3CF2CF2B24 0A912H(CH3)3C PhCF3CF2CF2B24 0A913H(CH3)2CH PhCF3CF2CF2B24 0A914HCH3(CH2)2PhCF3CF2CF2B24 0A915HCH3OCH2PhCF3CF2CF2B24 0A916HCH3O(CH2)2PhCF3CF2CF2B24 0A917HPh PhCF3CF2CF2B24 0A918HPhO PhCF3CF2CF2B24 0A919HPhS PhCF3CF2CF2B24 0A920HPhSOPhCF3CF2CF2B24 0A921HPhSO2PhCF3CF2CF2B24 0A922HCH3S PhCF3CF2CF2B24 0A923HCH3SO PhCF3CF2CF2B24 0A924HCF3PhCF3CF2CF2B24 0A925HF2CH PhCF3CF2CF2B24 0A926HHCC PhCF3CF2CF2B24 0A927HCH3CC PhCF3CF2CF2B24 0A928HCH2＝CHPhCF3CF2CF2B24 0A929HCH2＝CHCH2PhCF3CF2CF2B24 0A930HCH3SO2N(CH3) PhCF3CF2CF2B24 0A931H(CH3)2N PhCF3CF2CF2B24 0A932H(CH3)2NSO2PhCF3CF2CF2B24 0A933HCH3SCH2PhCF3CF2CF2B24 0A934HCH3SOCH2PhCF3CF2CF2B24 0A935HCH3SO2CH2PhCF3CF2CF2B24 0A936HCH3PhCF2ClB24 0A937HCH3CH2PhCF2ClB24 0A938H环丙基 PhCF2ClB24 0A939H(CH3)3C PhCF2ClB24 0A940H(CH3)2CH PhCF2ClB24 0化合物序号R2R3R4R5Q1pA941 HCH3(CH2)2PhCF2ClB24 0A942 HCH3OCH2PhCF2ClB24 0A943 HCH3O(CH2)2PhCF2ClB24 0A944 HPh PhCF2ClB24 0A945 HPhO PhCF2ClB24 0A946 HPhS PhCF2ClB24 0A947 HPhSO PhCF2ClB24 0A948 HPhSO2PhCF2ClB24 0A949 HCH3SPhCF2ClB24 0A950 HCH3SO PhCF2ClB24 0A951 HCF3PhCF2ClB24 0A952 HF2CHPhCF2ClB24 0A953 HHCC PhCF2ClB24 0A954 HCH3CC PhCF2ClB24 0A955 HCH2＝CH PhCF2ClB24 0A956 HCH2＝CHCH2PhCF2ClB24 0A957 HCH3SO2N(CH3) PhCF2ClB24 0A958 H(CH3)2NPhCF2ClB24 0A959 H(CH3)2NSO2PhCF2ClB24 0A960 HCH3SCH2PhCF2ClB24 0A961 HCH3SOCH2PhCF2ClB24 0A962 HCH3SO2CH2PhCF2ClB24 0A963 HCH3PhCHF2B24 0A964 HCH3CH2PhCHF2B24 0A965 H(CH3)3CPhCHF2B24 0A966 H(CH3)2CH PhCHF2B24 0A967 H环丙基PhCHF2B24 0A968 HCH3(CH2)2PhCHF2B24 0A969 HCH3OCH2PhCHF2B24 0A970 HCH3O(CH2)2PhCHF2B24 0A971 HPhPhCHF2B24 0A972 HPhO PhCHF2B24 0化合物序号 R2R3R4R5Q1pA973 HPhS PhCHF2B24 0A974 HPhSO PhCHF2B24 0A975 HPhSO2PhCHF2B24 0A976 HCH3S PhCHF2B24 0A977 HCH3SOPhCHF2B24 0A978 HCF3PhCHF2B24 0A979 HF2CH PhCHF2B24 0A980 HHCC PhCHF2B24 0A981 HCH3CCPhCHF2B24 0A982 HCH2＝CH PhCHF2B24 0A983 HCH2＝CHCH2PhCHF2B24 0A984 HCH3SO2N(CH3) PhCHF2B24 0A985 H(CH3)2N PhCHF2B24 0A986 H(CH3)2NSO2PhCHF2B24 0A987 HCH3SCH2PhCHF2B24 0A988 HCH3SOCH2PhCHF2B24 0A989 HCH3SO2CH2PhCHF2B24 0A990 HCH3PhCCl3B24 0A991 HCH3CH2PhCCl3B24 0A992 H(CH3)3C PhCCl3B24 0A993 H(CH3)2CHPhCCl3B24 0A994 H环丙基 PhCCl3B24 0A995 HCH3(CH2)2PhCCl3B24 0A996 HCH3OCH2PhCCl3B24 0A997 HCH3O(CH2)2PhCCl3B24 0A998 HPh PhCCl3B24 0A999 HPhOPhCCl3B24 0A1000HPhSPhCCl3B24 0A1001HPhSO PhCCl3B24 0A1002HPhSO2PhCCl3B24 0A1003HCH3S PhCCl3B24 0A1004HCH3SO PhCCl3B24 0化合物序号R2R3R4R5Q1pA1005 H CF3PhCCl3B24 0A1006 H F2CH PhCCl3B24 0A1007 H HCCPhCCl3B24 0A1008 H CH3CC PhCCl3B24 0A1009 H CH2＝CH PhCCl3B24 0A1010 H CH2＝CHCH2PhCCl3B24 0A1011 H CH3SO2N(CH3)PhCCl3B24 0A1012 H (CH3)2N PhCCl3B24 0A1013 H (CH3)2NSO2PhCCl3B24 0A1014 H CH3SCH2PhCCl3B24 0A1015 H CH3SOCH2PhCCl3B24 0A1016 H CH3SO2CH2PhCCl3B24 0A1017 F H H CF3B24 0A1018 CI H H CF3B24 0A1019 Br H H CF3B24 0A1020 NC H H CF3B24 0A1021 CH3SO2O H H CF3B24 0A1022 CH3O H H CF3B24 0A1023 CH3CH2O H H CF3B24 0A1024 CH2CH＝CH2O H H CF3B24 0A1025 HCCCH2OH H CF3B24 0A1026 PhCH2S H H CF3B24 0A1027 PhCH2SO2H H CF3B24 0A1028 CICH2CH2H H CF3B24 0A1029 BrCH2H H CF3B24 0A1030 FCH2H H CF3B24 0A1031 CHF2CH2H H CF3B24 0A1032 CF3CH2H H CF3B24 0A1033 [l，3]-咪唑-l-基甲基H H CF3B24 0A1034 CHCl2CH2H H CF3B24 0A1035 ClCH＝CHH H CF3B24 0化合物序号R2R3R4R5Q1pA1036 Cl2C＝CH H HCF3B24 0A1037 CF3CH＝CH H HCF3B24 0A1038 ClCCH HCF3B24 0A1039 PhCH2H HCF3B24 0A1040 CH3CH2CH3HCF3B24 0A1041 CH3OH HCF3B24 0A1042 CH3F HCF3B24 0A1043 CH3Cl HCF3B24 0A1044 F CH3HCF3B24 0A1045 Cl CH3HCF3B24 0A1046 H F HCF3B24 0A1047 H Cl HCF3B24 0A1048 H Br HCF3B24 0A1049 H OH HCF3B24 0A1050 H OCH3HCF3B24 0A1051 H OCHF2HCF3B24 0A1052 H OSO2CH3HCF3B24 0A1053 H OSO2CF3HCF3B24 0A1054 H ClCH2HCF3B24 0A1055 H BrCH2HCF3B24 0A1056 H FCH2HCF3B24 0A1057 H CHF2CH2HCF3B24 0A1058 H CF3CH2HCF3B24 0A1059 H 三唑基甲基 HCF3B24 0A1060 H CHCl2CH2HCF3B24 0A1061 H ClCH＝CHHCF3B24 0A1062 H Cl2C＝CH HCF3B24 0A1063 H CF3CH＝CH HCF3B24 0A1064 H ClCCHCF3B24 0A1065 H CH3C(O HCF3B24 0A1066 H Ph HCF3B24 0A1067 H SO2CH3HCF3B24 0化合物序号 R2R3R4R5Q1pA1068H SO2CF3HCF3B24 0A1069H NCHCF3B24 0A1070H NO2HCF3B24 0A1071CH3H FCF3B24 0A1072CH3H Cl CF3B24 0A1073CH3H Br CF3B24 0A1074CH3H NC CF3B24 0A1075CH3H CH3OCF3B24 0A1076CH3H CH3SCF3B24 0A1077CH3H CH3SO CF3B24 0A1078CH3H CH3SO2CF3B24 0A1079CH3CH2OCH2H HCF3B24 0A1080PhOCH2H HCF3B24 0A1081 H HCF3B24 0A1082(CH3)2CH2OCH2H HCF3B24 0A1083BrCH2CH2H HCF3B24 0A1084FCH2CH2H HCF3B24 0A1085H H CF30A1086 H H CF3B24 0A1087 H H CF3B24 0A1088 H H CF3B24 0A1089 H H CF3B24 0A1090 H H CF3B24 0化合物序号 R2R3R4R5Q1pNO.A1091 丙基-CH2H H CF3B24 0A1092 2，2-二氯环丙-1-基 H H CF3B24 0A1093 CH3OC(O)CH＝CH H H CF3B24 0A1094 CH3CH2OC(O)CH＝CH H H CF3B24 0A1095 ClCH2CH＝CHH H CF30A1096 CH＝C＝CH H H CF3B24 0A1097 (CH3)2NCH2H H CF3B24 0A1098 HOCH2H H CF3B24 0A1099 CH3C(O)OCH2H H CF3B24 0A1100 PhC(O)OCH2H H CF3B24 0A1101 PhCH2CH2H H CF3B24 0A1102 CH3OC(O)CH2H H CF3B24 0A1103 NCCH2H H CF3B24 0A1104 CH3(CH2)7SCH2H H CF3B24 0A1105 CH3(CH2)7SOCH2H H CF3B24 0A1106 CH3(CH2)7SO2CH2H H CF3B24 0A1107 H H CF3B24 0A1108 ClCH2CCH H CF3B24 0A1109 CHF2CH2CH2H H CF3B24 0A1110 CHCl2CH2CH2H H CF3B24 0A1111 CF3SO2O H H CF3B24 0A1112 H H CF3B24 0A1113 H H CF3B24 0A1114 H H CF3B24 0A1115 H H CF3B24 0化合物序号R2R3R4R5Q1pA1116H H CF3B24 0A1117H H CF3B24 0A1118 CH3ON＝CHCH2H H CF3B24 0A1119 O＝CHCH2H H CF3B24 0A1120 CH3CH2OCH2H H CF2ClB24 0A1121 PhOCH2H H CF2ClB24 0A1122 H H CF2ClB24 0A1123 (CH3)2CH2OCH2H H CF2ClB24 0A1124 BrCH2H H CF2ClB24 0A1125 FCH2H H CF2ClB24 0A112 H H CF2ClB24 0A1127H H CF2ClB24 0A1128H H CF2ClB24 0A1129H H CF2ClB24 0A1130 H H CF2ClB24 0A1131 H H CF2ClB24 0A1132 环丙基-CH2H H CF2ClB24 0A1133 2，2-二氯环丙-1-基 H H CF2ClB24 0A1134 CH3OC(O)CH＝CHH H CF2ClB24 0A1135 CH3CH2OC(O)CH＝CHH H CF2ClB24 0化合物序号 R2R3R4R5Q1pA1136 ClCH2CH＝CH H H CF2Cl B24 0A1137 CH＝C＝CHH H CF2Cl B24 0A1138 (CH3)2NCH2H H CF2Cl B24 0A1139 HOCH2H H CF2Cl B24 0A1140 CH3C(O)OCH2H H CF2Cl B24 0A1141 PhC(O)OCH2H H CF2Cl B24 0A1142 PhCH2H H CF2Cl B24 0A1143 CH3OC(O)CH2H H CF2Cl B24 0A1144 NCCH2H H CF2Cl B24 0A1145 CH3(CH2)7SCH2H H CF2Cl B24 0A1146 CH3(CH2)7SOCH2H H CF2Cl B24 0A1147 CH3(CH2)7SO2CH2H H CF2Cl B24 0A1148 H H CF2Cl B24 0A1149 ClCH2CC H H CF2Cl B24 0A1150 Br H H CF2Cl B24 0A1151 Cl H H CF2Cl B24 0A1152 CF3SO2O H H CF2Cl B24 0A1153 H H CF2Cl B24 0A1154 H H CF2Cl B24 0A1155 H H CF2Cl B24 0A1156H H CF2Cl B24 0A1157H H CF2Cl B24 0A1158H H CF2Cl B24 0A1159 CH3ON＝CHCH2H H CF2Cl B24 0A1160 O＝CHCH2H H CF2Cl B24 0化合物序号R2R3R4R5Q1pA1161 CH3CH2OCH2H H CF2H B24 0A1162 PhOCH2H H CF2H B24 0A1163 H H CF2H B24 0A1164 (CH3)2CH2OCH2H H CF2H B24 0A1165 BrCH2H H CF2H B24 0A1166 FCH2H H CF2H B24 0A1167H H CF2H B24 0A1168 H H CF2H B24 0A1169 H H CF2H B24 0A1170 H H CF2H B24 0A1171 H H CF2H B24 0A1172 H H CF2H B24 0A1173 环丙基-CH2H H CF2H B24 0A1174 2，2-二氯环丙-1-基H H CF2H B24 0A1175 CH3OC(O)CH＝CH H H CF2H B24 0A1176 CH3CH2OC(O)CH＝CH H H CF2H B24 0A1177 ClCH2CH＝CH H H CF2H B24 0A1178 CH＝C＝CH H H CF2H B24 0A1179 (CH3)2NCH2H H CF2H B24 0A1180 HOCH2H H CF2H B24 0A1181 CH3C(O)OCH2H H CF2H B24 0A1182 PhC(O)OCH2H H CF2H B24 0化合物序号 R2R3R4R5Q1pA1183 PhCH2HH CF2HB24 0A1184 CH3OC(O)CH2HH CF2HB24 0A1185 NCCH2HH CF2HB24 0A1186 CH3(CH2)7SCH2HH CF2HB24 0A1187 CH3(CH2)7SOCH2HH CF2HB24 0A1188 CH3(CH2)7SO2CH2HH CF2HB24 0A1189 HH CF2HB24 0A1190 ClCH2CC HH CF2HB24 0A1191 Br HH CF2HB24 0A1192 Cl HH CF2HB24 0A1193 CF3SO2O HH CF2HB24 0A1194 HH CF2HB24 0A1195 HH CF2HB24 0A1196 HH CF2HB24 0A1197 HH CF2HB24 0A1198 HH CF2HB24 0A1199 HH CF2HB24 0A1200 CH3ON＝CHCH2HH CF2HB24 0A1201 O＝CHCH2HH CF2HB24 0A1202 CH3CH＝CH HH CF3B24 0A1203 CH3SO2NH HH CF3B24 0A1204 CH3CH2CH2O HCH3CF3B24 0A1205 Cl CH3H CF3B24 0A1206 F2CHO HH CF3B24 0A1207 CH3CH2C(O)OCH2HH CF3B24 0化合物序号R2R3R4R5Q1pA1208CH3CH2OC(O)OCH2HHCF3B24 0A1209CH3OCH2OCH2HHCF3B24 0A1210CH3HHCF3B24 1A1211CH3CH2HHCF3B24 1A1212环丙基 HHCF3B24 1A1213CH3(CH2)2HHCF3B24 1A1214CH3OCH2HHCF3B24 1A1215CF3HHCF3B24 1A1216F2CH HHCF3B24 1A1217ClCH2HHCF3B24 1A1218CH3SO2CH2HHCF3B24 1A1219CH3CF3HCH3B24 1A1220CH3CH2OCH2HHCF3B24 1A1221PhOCH2HHCF3B24 1A1222(CH3)2CH2OCH2HHCF3B24 1A1223BrCH2HHCF3B24 1A1224FCH2HHCF3B24 1A1225 HHCF3B24 1A1226 HHCF3B24 1A1227环丙基-CH2HHCF3B24 1A12282，2-二氯环丙-1-基 HHCF3B24 1A1229(CH3)2NCH2HHCF3B24 1A1230HOCH2HHCF3B24 1A1231CH3C(O)OCH2HHCF3B24 1A1232PhC(O)OCH2HHCF3B24 1A1233PhCH2HHCF3B24 1A1234CH3OC(O)CH2HHCF3B24 1A1235NCCH2HHCF3B24 1化合物序号R2R3R4R5Q1pA1236CH3(CH2)7SO2CH2HHCF3B24 1A1237Br HHCF3B24 1A1238Cl HHCF3B24 1A1239O＝CHCH2HHCF3B24 1A1240CH3HHCF2ClB24 1A1241CH3CH2HHCF2ClB24 1A1242环丙基 HHCF2ClB24 1A1243CH3(CH2)2HHCF2ClB24 1A1244CH3OCH2HHCF2ClB24 1A1245CF3HHCF2ClB24 1A1246F2CHHHCF2ClB24 1A1247ClCH2HHCF2ClB24 1A1248CH3SO2CH2HHCF2ClB24 1A1249CH3CF3HCF2ClB24 1A1250CH3CH2OCH2HHCF2ClB24 1A1251PhOCH2HHCF2ClB24 1A1252(CH3)2CH2OCH2HHCF2ClB24 1A1253BrCH2HHCF2ClB24 1A1254FCH2HHCF2ClB24 1A1255 HHCF2ClB24 1A1256HHCF2ClB24 1A1257环丙基-CH2HHCF2ClB24 1A12582，2-二氯环丙-1-基 HHCF2ClB24 1A1259(CH3)2NCH2HHCF2ClB24 1A1260HOCH2HHCF2ClB24 1A1261CH3C(O)OCH2HHCF2ClB24 1A1262PhC(O)OCH2HHCF2ClB24 1A1263PhCH2HHCF2ClB24 1化合物序号R2R3R4R5Q1pA1264CH3OC(O)CH2HHCF2Cl B24 1A1265NCCH2HHCF2Cl B24 1A1266CH3(CH2)7SO2CH2HHCF2Cl B24 1A1267Br HHCF2Cl B24 1A1268Cl HHCF2Cl B24 1A1269O＝CHCH2HHCF2Cl B24 1A1270CH3HHCF2HB24 1A1271CH3CH2HHCF2HB24 1A1272环丙基 HHCF2HB24 1A1273CH3(CH2)2HHCF2HB24 1A1274CH3OCH2HHCF2HB24 1A1275CF3HHCF2HB24 1A1276F2CHHHCF2HB24 1A1277ClCH2HHCF2HB24 1A1278CH3SO2CH2HHCF2HB24 1A1279CH3CF3HCF2HB24 1A1280CH3CH2OCH2HHCF2HB24 1A1281PhOCH2HHCF2HB24 1A1282(CH3)2CH2OCH2HHCF2HB24 1A1283BrCH2HHCF2HB24 1A1284FCH2HHCF2HB24 1A1285 HHCF2HB24 1A1286 HHCF2HB24 1A1287环丙基-CH2HHCF2HB24 1A12882，2-二氯环丙-1-基 HHCF2HB24 1A1289(CH3)2NCH2HHCF2HB24 1A1290HOCH2HHCF2HB24 1A1291CH3C(O)OCH2HHCF2HB24 1化合物序号R2R3R4R5Q1pA1292PhC(O)OCH2HHCF2HB24 1A1293PhCH2HHCF2HB24 1A1294CH3OC(O)CH2HHCF2HB24 1A1295NCCH2HHCF2HB24 1A1296CH3(CH2)7SO2CH2HHCF2HB24 1A1297Br HHCF2HB24 1A1298Cl HHCF2HB24 1A1299O＝CHCH2HHCF2HB24 1A1300CH3HHCF3CF2B24 1A1301HO HPh CF3B24 0A1302CH3HCH2＝CH CF3B24 0A1303CH3HCH3CH2OCF3B24 0A1304HO CH3HCF3B24 0A1305HO HHCF3B24 0A1306(CH3CH2)2N(O)CO HHCF3B24 0A1307CH3H甲苯磺酰基-O CF3B24 0A1308CH3HCH3CC CF3B24 0A1309CH3HHCC CF3B24 0A1310CH3HClCH2CC CF3B24 0A1311CH3HPhCH2O CF3B24 0A1312CH3HCF3SO2OCF3B24 0A1313CH3H(CH3)2NCF3B24 0A1314CH3HCH3C(O)OCF3B24 0A1315CH3HCH3CH2C(O) CF3B24 0OA1316CH3HPhC(O)O CF3B24 0A1317CH3H3-吡啶基 CF3B24 0A1318CH3OCH2OCH2HHCF2Cl B24 0A1319CH3OCH2OCH2HHCF2HB24 0A1320CH3OCH2OCH2HHCF2CF3B24 0A1321CH3OCH2OCH2HHCF3B24 1A1322CH3OHCH3CF3B24 0
就各表中的结构式而言(例如表7，化合物A1088，取代基R2)，与吡啶环的键合部位位于结构式的右手一侧。端价键为甲基。表8式Ib化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2 B3B4B5B6B7B8B9B10 B11 B12B13 B14B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表9式Ic化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表10式Id化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B601B602B603B604B605B606B607B608B609B610B611B612B613B614B615B616B617B618B619B620B621B622B623B624B625B626B627B628B629B630B631B632B633B634B635B636B637B638B639B640B641B642B643B644B645B646B647B648B649B650B651B652B653B654B655B656B657B658B659B660B661B662B663B664B665B666B667B668B669B670B671B672B773B774B775B776B777B778B779B780B781B782B783B784B785B786B787B788B789B790B791B792B793B794B795B796B797B798B799B800B801B802B803B804B805B806B807B808B809B810B811B812B813B814B815B816B817B818B819B820B821B822B823B824B825B826B827B828B829B830B831B832B833B834B835B836B837B838B839B840B841B842B843B844B845B846B847B848B849B850B851B852B853B854B855B856B857B858B859B860B861B862B863B864B865B866B867B868B869B870B871B872B873B874B875B876B877B878B879B880B881B882B883B884B885B886B887B888B889B890B891B892B893B894B895B896B897B898B899B900B901B902B903B904B905B906B907B908B909B910B911B912B913B914B915B916B917B918B919B920B921B922B923B924B925B926B927B928B929B930B931B932B933B934B935B936B937B938B939B940B941B942B943B944B945B946B947B948B949B950B951B952B953B954B955B956B957B958B959B960B961B962B963B964B965B966B967B968B969B970B971B972B973B974B975B976B977B978B979B980B981B982B983B984B985B986B987B988B989B990B991B992B993B994B995B996B997B998B999B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表11式Ie化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表12式If化合物 Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表13式Ig化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表14式Ih化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3 B4B5B6B7B8B9B10 B11B12B13 B14 B15 B16 B17 B18 B19 B20 B21B22 B23 -Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表15式Ik化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表16式Im化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1B2B3B4B5B6B7B8B9B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23-B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100 B101 B102 B103 B104 B105 B106 B107 B108B109 B110 B111 B112 B113 B114 B115 B116 B117 B118 B119 B120B121 B122 B123 B124 B125 B126 B127 B128 B129 B130 B131 B132B133 B134 B135 B136 B137 B138 B139 B140 B141 B142 B143 B144B145 B146 B147 B148 B149 B150 B151 B152 B153 B154 B155 B156B157 B158 B159 B160 B161 B162 B163 B164 B165 B166 B167 B168B169 B170 B171 B172 B173 B174 B175 B176 B177 B178 B179 B180B181 B182 B183 B184 B185 B186 B187 B188 B189 B190 B191 B192B193 B194 B195 B196 B197 B198 B199 B200 B201 B202 B203 B204B205 B206 B207 B208 B209 B210 B211 B212 B213 B214 B215 B216B217 B218 B219 B220 B221 B222 B223 B224 B225 B226 B227 B228B229 B230 B231 B232 B233 B234 B235 B236 B237 B238 B239 B240B241 B242 B243 B244 B245 B246 B247 B248 B249 B250 B251 B252B253 B254 B255 B256 B257 B258 B259 B260 B261 B262 B263 B264B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1217表17式In化合物(P为0或1) Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1 B2 B3 B4 B5 B6 B7 B8 B9 B10 B11 B12B13 B14 B15 B16 B17 B18 B19 B20 B21 B22 B23 -B25 B26 B27 B28 B29 B30 B31 B32 B33 B34 B35 B36B37 B38 B39 B40 B41 B42 B43 B44 B45 B46 B47 B48B49 B50 B51 B52 B53 B54 B55 B56 B57 B58 B59 B60B61 B62 B63 B64 B65 B66 B67 B68 B69 B70 B71 B72B73 B74 B75 B76 B77 B78 B79 B80 B81 B82 B83 B84B85 B86 B87 B88 B89 B90 B91 B92 B93 B94 B95 B96B97 B98 B99 B100B101B102 B103B104B105B106B107 B108B109 B110B111 B112B113B114 B115B116B117B118B119 B120B121 B122B123 B124B125B126 B127B128B129B130B131 B132B133 B134B135 B136B137B138 B139B140B141B142B143 B144B145 B146B147 B148B149B150 B151B152B153B154B155 B156B157 B158B159 B160B161B162 B163B164B165B166B167 B168B169 B170B171 B172B173B174 B175B176B177B178B179 B180B181 B182B183 B184B185B186 B187B188B189B190B191 B192B193 B194B195 B196B197B198 B199B200B201B202B203 B204B205 B206B207 B208B209B210 B211B212B213B214B215 B216B217 B218B219 B220B221B222 B223B224B225B226B227 B228B229 B230B231 B232B233B234 B235B236B237B238B239 B240B241 B242B243 B244B245B246 B247B248B249B250B251 B252B253 B254B255 B256B257B258 B259B260B261B262B263 B264Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B265 B266 B267 B268 B269 B270 B271 B272 B273 B274 B275 B276B277 B278 B279 B280 B281 B282 B283 B284 B285 B286 B287 B288B289 B290 B291 B292 B293 B294 B295 B296 B297 B298 B299 B300B301 B302 B303 B304 B305 B306 B307 B308 B309 B310 B311 B312B313 B314 B315 B316 B317 B318 B319 B320 B321 B322 B323 B324B325 B326 B327 B328 B329 B330 B331 B332 B333 B334 B335 B336B337 B338 B339 B340 B341 B342 B343 B344 B345 B346 B347 B348B349 B350 B351 B352 B353 B354 B355 B356 B357 B358 B359 B360B361 B362 B363 B364 B365 B366 B367 B368 B369 B370 B371 B372B373 B374 B375 B376 B377 B378 B379 B380 B381 B382 B383 B384B385 B386 B387 B388 B389 B390 B391 B392 B393 B394 B395 B396B397 B398 B399 B400 B401 B402 B403 B404 B405 B406 B407 B408B409 B410 B411 B412 B413 B414 B415 B416 B417 B418 B419 B420B421 B422 B423 B424 B425 B426 B427 B428 B429 B430 B431 B432B433 B434 B435 B436 B437 B438 B439 B440 B441 B442 B443 B444B445 B446 B447 B448 B449 B450 B451 B452 B453 B454 B455 B456B457 B458 B459 B460 B461 B462 B463 B464 B465 B466 B467 B468B469 B470 B471 B472 B473 B474 B475 B476 B477 B478 B479 B480B481 B482 B483 B484 B485 B486 B487 B488 B489 B490 B491 B492B493 B494 B495 B496 B497 B498 B499 B500 B501 B502 B503 B504B505 B506 B507 B508 B509 B510 B511 B512 B513 B514 B515 B516B517 B518 B519 B520 B521 B522 B523 B524 B525 B526 B527 B528B529 B530 B531 B532 B533 B534 B535 B536 B537 B538 B539 B540B541 B542 B543 B544 B545 B546 B547 B548 B549 B550 B551 B552B553 B554 B555 B556 B557 B558 B559 B560 B561 B562 B563 B564B565 B566 B567 B568 B569 B570 B571 B572 B573 B574 B575 B576B577 B578 B579 B580 B581 B582 B583 B584 B585 B586 B587 B588B589 B590 B591 B592 B593 B594 B595 B596 B597 B598 B599 B600B601 B602 B603 B604 B605 B606 B607 B608 B609 B610 B611 B612B613 B614 B615 B616 B617 B618 B619 B620 B621 B622 B623 B624B625 B626 B627 B628 B629 B630 B631 B632 B633 B634 B635 B636B637 B638 B639 B640 B641 B642 B643 B644 B645 B646 B647 B648B649 B650 B651 B652 B653 B654 B655 B656 B657 B658 B659 B660Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B661 B662 B663 B664 B665 B666 B667 B668 B669 B670 B671 B672B773 B774 B775 B776 B777 B778 B779 B780 B781 B782 B783 B784B785 B786 B787 B788 B789 B790 B791 B792 B793 B794 B795 B796B797 B798 B799 B800 B801 B802 B803 B804 B805 B806 B807 B808B809 B810 B811 B812 B813 B814 B815 B816 B817 B818 B819 B820B821 B822 B823 B824 B825 B826 B827 B828 B829 B830 B831 B832B833 B834 B835 B836 B837 B838 B839 B840 B841 B842 B843 B844B845 B846 B847 B848 B849 B850 B851 B852 B853 B854 B855 B856B857 B858 B859 B860 B861 B862 B863 B864 B865 B866 B867 B868B869 B870 B871 B872 B873 B874 B875 B876 B877 B878 B879 B880B881 B882 B883 B884 B885 B886 B887 B888 B889 B890 B891 B892B893 B894 B895 B896 B897 B898 B899 B900 B901 B902 B903 B904B905 B906 B907 B908 B909 B910 B911 B912 B913 B914 B915 B916B917 B918 B919 B920 B921 B922 B923 B924 B925 B926 B927 B928B929 B930 B931 B932 B933 B934 B935 B936 B937 B938 B939 B940B941 B942 B943 B944 B945 B946 B947 B948 B949 B950 B951 B952B953 B954 B955 B956 B957 B958 B959 B960 B961 B962 B963 B964B965 B966 B967 B968 B969 B970 B971 B972 B973 B974 B975 B976B977 B978 B979 B980 B981 B982 B983 B984 B985 B986 B987 B988B989 B990 B991 B992 B993 B994 B995 B996 B997 B998 B999 B1000B1001 B1002 B1003 B1004 B1005 B1006 B1007 B1008 B1009 B1010 B1011 B1012B1013 B1014 B1015 B1016 B1017 B1018 B1019 B1020 B1021 B1022 B1023 B1024B1025 B1026 B1027 B1028 B1029 B1030 B1031 B1032 B1033 B1034 B1035 B1036B1037 B1038 B1039 B1040 B1041 B1042 B1043 B1044 B1045 B1046 B1047 B1048B1049 B1050 B1051 B1052 B1053 B1054 B1055 B1056 B1057 B1058 B1059 B1060B1061 B1062 B1063 B1064 B1065 B1066 B1067 B1068 B1069 B1070 B1071 B1072B1073 B1074 B1075 B1076 B1077 B1078 B1079 B1080 B1081 B1082 B1083 B1084B1085 B1086 B1087 B1088 B1089 B1090 B1091 B1092 B1093 B1094 B1095 B1096B1097 B1098 B1099 B1100 B1101 B1102 B1103 B1104 B1105 B1106 B1107 B1108B1109 B1110 B1111 B1112 B1113 B1114 B1115 B1116 B1117 B1118 B1119 B1120B1121 B1122 B1123 B1124 B1125 B1126 B1127 B1128 B1129 B1130 B1131 B1132B1133 B1134 B1135 B1136 B1137 B1138 B1139 B1140 B1141 B1142 B1143 B1144B1145 B1146 B1147 B1148 B1149 B1150 B1151 B1152 B1153 B1154 B1155 B1156Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1Q1B1157 B1158 B1159 B1160 B1161 B1162 B1163 B1164 B1165 B1166 B1167 B1168B1169 B1170 B1171 B1172 B1173 B1174 B1175 B1176 B1177 B1178 B1179 B1180B1181 B1182 B1183 B1184 B1185 B1186 B1187 B1188 B1189 B1190 B1191 B1192B1193 B1194 B1195 B1196 B1197 B1198 B1199 B1200 B1201 B1202 B1203 B1204B1205 B1206 B1207 B1208 B1209 B1210 B1211 B1212 B1213 B1214 B1215 B1216B1217表18式I0化合物(P为0或1) Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2C1 C2C3C4 C5 C6 C7 C8 C9C10 C11 C12C13 C14 C15 C16 C17 C18 C19 C20 C21 C22 C23 C24C25 C26 C27 C28 C29 C30 C31 C32 C33 C34 C35 C36C37 C38 C39 C40 C41 C42 C43 C44 C45 C46 C47 C48C49 C50 C51 C52 C53 C54 C55 C56 C57 C58 C59 C60C61 C62 C63 C64 C65 C66 C67 C68 C69 C70 C71 C72C73 C74 C75 C76 C77 C78 C79 C80 C81 C82 C83 C84C85 C86 C87 C88 C89 C90 C91 C92 C93 C94 C95 C96C97 C98 C99 C100 C101 C102 C103 C104 C105 C106 C107 C108C109 C110 C111 C112 C113 C114 C115 C116 C117 C118 C119 C120C121 C122 C123 C124 C125 C126 C127 C128 C129 C130 C131 C132C133 C134 C135 C136 C137 C138 C139 C140 C141 C142 C143 C144C145 C146 C147 C148 C149 C150 C151表19式1q化合物(P为0或1) Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2Q2C1C2 C3 C4C5C6 C7C8 C9 C10 C11 C12C13 C14 C15 C16 C17 C18 C19 C20 C21 C22 C23 C24C25 C26 C27 C28 C29 C30 C31 C32 C33 C34 C35 C36C37 C38 C39 C40 C41 C42 C43 C44 C45 C46 C47 C48C49 C50 C51 C52 C53 C54 C55 C56 C57 C58 C59 C60C61 C62 C63 C64 C65 C66 C67 C68 C69 C70 C71 C72C73 C74 C75 C76 C77 C78 C79 C80 C81 C82 C83 C84C85 C86 C87 C88 C89 C90 C91 C92 C93 C94 C95 C96C97 C98 C99 C100 C101 C102 C103 C104 C105 C106 C107 C108C109 C110 C111 C112 C113 C114 C115 C116 C117 C118 C119 C120C121 C122 C123 C124 C125 C126 C127 C128 C129 C130 C131 C132C133 C134 C135 C136 C137 C138 C139 C140 C141 C142 C143 C144C145 C146 C147 C148 C149 C150 C151表20式Ir化合物(P为0或1) Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12D13 D14 D15 D16 D17 D18 D19 D20 D21 D22 D23 D24D25 D26 D27 D28 D29 D30 D31 D32 D33 D34 D35 D36D37 D38 D39 D40 D41 D42 D43 D44 D45 D46 D47 D48Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3D49 D50 D51 D52 D53 D54 D55 D56 D57 D58 D59 D60D61 D62 D63 D64 D65 D66 D67 D68 D69 D70 D71 D72D73 D74 D75 D76 D77 D78 D79 D80 D81 D82 D83 D84D85 D86 D87 D88 D89 D90 D91 D92 D93 D94 D95 D96D97 D98 D99 D100 D101 D102 D103 D104 D105 D106 D107 D108D109 D110 D111 D112 D113 D114 D115 D116 D117 D118 D119 D120D121 D122 D123 D124 D125 D126 D127 D128 D129 D130 D131 D132D133 D134 D135 D136 D137 D138 D139 D140表21式Is化合物(P为0或1) Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3Q3D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12D13 D14 D15 D16 D17 D18 D19 D20 D21 D22 D23 D24D25 D26 D27 D28 D29 D30 D31 D32 D33 D34 D35 D36D37 D38 D39 D40 D41 D42 D43 D44 D45 D46 D47 D48D49 D50 D51 D52 D53 D54 D55 D56 D57 D58 D59 D60D61 D62 D63 D64 D65 D66 D67 D68 D69 D70 D71 D72D73 D74 D75 D76 D77 D78 D79 D80 D81 D82 D83 D84D85 D86 D87 D88 D89 D90 D91 D92 D93 D94 D95 D96D97 D98 D99 D100 D101 D102 D103 D104 D105 D106 D107 D108D109 D110 D111 D112 D113 D114 D115 D116 D117 D118 D119 D120D121 D122 D123 D124 D125 D126 D127 D128 D129 D130 D131 D132D133 D134 D135 D136 D137 D138 D139 D140 Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E15E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30表23式Iu化合物(P为0或1) Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4Q4E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E15E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30表24式Iv化合物(P为0或1) Q5Q5Q5Q5Q5Q5F1 F2 F3 F4 F5 F6表25式Iw化合物(P为0或1) Q5Q5Q5Q5Q5Q5F1 F2 F3 F4 F5 F6表26.中间体的物理数据熔点℃化合物 物理数据 化合物 物理数据A1799-100 A1025 结晶A7 105-106A1206 94-95A9 73-74 A1022 油A6 148-150A1203 结晶A26143-144A21 无定形A34170-171A1023110-111A1026 结晶 A1085188-191A1304 结晶 A1088157-158A1301 结晶 A1092结晶A1018 110-111A1095136-138A1 195-197A1096194-196A2 150-151A124 135-136A15164-166A31 209-210A27107-108H-B1057 166-167A29173-174H-B1058 结晶A32145-146H-B1061 结晶A30178-181H-B1063 结晶A4 143-144H-B1065 油A3 148-149H-B1066 150-152A10166-167H-B1067 122-123A8 123-124H-B1069 117-118化合物 物理数据化合物物理数据A5 81-82 H-B1070结晶A154108-110 H-C1 116-118A64 134-135 H-C24 172-175A94 134-135 A1205 结晶A531结晶H-D113 油A1045 结晶H-F5 油A1322 结晶H-E16 145-148A184146-147 A1088 157-158A358155-156 A1103 152-153表27.上表中所示式I化合物的物理数据熔点℃化合物序号m.p. 物理状态化合物序号 m.p.物理状态A2-B190-92结晶A34-B1 53-54 结晶A2-B1082 - 树脂A9-B1 - 油状物A2-B1083 - 树脂A184-B1 98-99 结晶A2-B90 - 树脂A184-B24 101-102结晶A2-B68 120-121 结晶A7-B24- 油状物A2-B24 75-76结晶A3-B24- 油状物A7-B1 - 油状物 A34-B24 51-52 结晶A2-B73 - 树脂A2-B1091 - 油状物A2-B75 - 无定形 A2-B1 092 - 油状物A2-B95 106-107 结晶A8-B24 52-53 结晶A2-B93 95-96结晶A18-B24 - 油状物A8-B197-98结晶A2-B552 - 树脂A2-B925- 油状物 A2-C1 52 - 油状物A3-B142-44结晶A2-B69- 树脂A94-B1 57-58结晶A2-D36- 树脂A2-B1057 - 无定形 A2-B618 - 树脂A2-B1063 - 油状物 A2-B49- 树脂A2-B1061 - 油状物 A2-D71- 树脂A2-B133 58-60结晶A2-B1093 - 树脂化合物序号m.p.物理状态化合物序号 m.p. 物理状态A2-B1058 89-91结晶 A2-B26 -油状物A64-B24 80-82结晶 A2-B33 -树脂A64-B1 49-51结晶 A2-B34 -腊状物A2-B1089 油状物 A2-B35 -腊状物A2-B31 151-153 结晶 A2-B1087 -粘性物A2-B1090 139-140 结晶 A2-B1094 -粘性物A154-B1 94-95 结晶 A2-B1088108-109 结晶A2-B46(顺式) 61-62 结晶 A531-B24 -粘性物A2-B46(反式) 83-84 结晶 A2-B1099 94-96 结晶A2-B91 - 树脂 A2-B1095 -粘性物A2-B2 - 树脂 A2-B1097 -油状物A2-B2987-88 结晶 A2-B1098 92-93 结晶A2-B1066- 粘性物 A2-C147-树脂A2-B25 - 油状物 A2-B70 -树脂A2-B1067- 树脂 A2-B49 -树脂A2-B1069- 油状物 A2-C1 -油状物A2-B1068- 粘性物 A2-B1096 -树脂A2-B1070- 粘性物 A2-B1085176-177 结晶A2-B5 - 树脂 A1022-B24 -油状物A2-C149 - 树脂 A2-C47 107-110 结晶A2-C146 - 油状物 A2-B1100128-130 结晶A2-B112 - 树脂 A8-B270-71 结晶A2-D140 - 油状物 A8-B1064 -树脂A2-B354 139-140 结晶 A2-B45 -树脂A2-E16 - 固体 A2-B10 -粘性物A6-B1123-124 结晶 A8-B133 68-69 结晶A6-B24 - 油状物 A8-B1101113-114 结晶A1322-B24 - 油状物 A8-B1106 -油状物A2-B1101 124-125 结晶 A2-D111(反式) -油状物A2-B156 - 油状物 A2-D111(顺式) -树脂A2-B144 - 树脂 A8-D111(反式) -油状物A2-B145 - 树脂 A8-D109 62-62 无定形A2-B134 - 树脂 A8-B35 -油状物化合物序号 m.p. 物理状态化合物序号m.p. 物理状态A1210-B354 220 结晶 A1023-B2 - 树脂A2-C2 - 油状物 A1023-B354 95-97 结晶A358-B1 - 油状物 A15-B354 - 树脂A2-D36 - 树脂 A8-B354 - 油状物A1208-B354 - 油状物 A8-B1067 - 油状物A2-D113(lsom.A) - 油状物 A8-C146 - 油状物A2-D113(lsom.B) - 油状物 A8-C1 - 油状物A2-D114(lsom.A) 159-160结晶 A94-B34108-110 结晶A2-D115 - 无定形 A94-B35 82-84 结晶A1025-B354 - 粘性物 A1210-B354- 无定形A2-B1102 124-125结晶 A2-B1105 119结晶A2-B1104 165-167结晶 A1099-B1107 - 无定形A1210-B1 117-119结晶 A2-B1123 - 树脂A8-B34 - 油状物 A8-B1123 - 树脂A8-B1103- 油状物 A2-B1138 - 树脂A8-B1063 90-92 结晶 A124-B1 60-65 结晶A8-B29 - 油状物 A1170-B1106-107 结晶A2-C24 - 油状物 A124-B34 -油状物A8-B552 - 油状物 A124-B35 -油状物A8-B156 - 树脂 A94-B2 53-57 结晶A1210-B1105 145-146玻璃状 A2-B1174 -结晶无定形物A1206-B354 - 无定形 A2-B1213133-134 结晶A8-B134 - 油状物 A3-B1213 -油状物A8-D36 - 油状物 A4-B1213 -油状物A8-B1213 71-72 结晶 A2-B1214 -树脂A8-F5 - 树脂 A2-F5 -树脂A1029-B1105 94.5-95结晶 A2-D109-油状物生物实施例实施例B1植物发芽前的除草作用(芽前作用)将单子叶和双子叶试验植物播种在置于塑料盆内的标准土壤中。播种后，随即喷施试验物质的水悬液(按照WO97/34485所述方法由25％浓度的可湿性粉剂(实施例F3，b)制备)或乳液(用25％浓度乳油(实施例F1，c)制备)，施用量为2 kg活性组份/公顷或250g活性组分/公顷(500升水/公顷)。然后使试验植物在温室中于最佳条件下生长。三周测试期后，分9个等级评价试验结果(1＝全部损伤，9＝没有作用)。1-4级(特别是1-3级)表示具有好至很好的除草作用。表B1a芽前作用化合物 g/ha 莎草番薯 狗尾草 白芥 茄 繁缕A2-B1 2000221221A2-B10822000222212A2-B10832000233423A2-B90 2000111111A2-B68 2000121212A2-B24 2000111211A2-B73 2000342222A2-B75 2000232212A2-B95 2000242212A2-B93 2000242212A3-B1 2000224232A94-B1 2000122112A2-B10632000121212A2-B10612000332212A2-B133 2000122212A64-B24 2000442212A2-B10892000122212A2-B31 2000234212A2-B46(cis) 2000121212化合物 g/ha 莎草 番薯 狗尾草白芥 茄 繁缕A2-B46(反式)2000121212A2-B91 2000121212A2-B2 2000111112A2-B25 2000232212A2-B10672000232233A2-B10682000222212A2-B10702000233222A2-C146 2000122212A2-B354 2000111112A34-B1 2000122223A9-B1 2000212112A184-B1 2000242212A184-B242000132212A3-B24 2000132212A8-B24 2000122213A18-B24 2000111112A2-B552 2000122212A2-C152 2000112212A2-B69 2000142211A2-D36 2000122211A2-B618 2000111211A2-B33 2000132213A2-B34 2000132212A2-B35 2000242222A2-B10952000342212A2-C147 2000242222A2-B49 2000242212A2-C1 2000231212A2-B11002000131212A8-B2 2000132212A8-B10642000243213A8-B11012000242211A2-B156 2000121212化合物 g/ha 莎草 番薯 狗尾草 白芥 茄 繁缕A2-B144 2000 34 2224A2-B134 2000 12 1211A1210-B354 2000 23 2112A2-C22000 23 1111A2-D36 2000 12 1231A2-D113(lsom.A) 2000 44 2133A2-D115 2000 33 2223A8-B34 2000 23 2222A8-B1103 2000 13 2112A2-C24 2000 12 1112表B1b芽前作用化合物 g/h 稷 马唐 稗 苘麻 苋藜A8-B1250222111A1022-B24250244341A2-B145 250224231A1208-B354 250111111A8-B1063 250233241A8-B552 250234141A8-B156 250333342A1210-B1105 250232141在式I化合物按照WO97/34485的实施例F2及F4-F8所述方法加工配制的情形下，试验得到同样的结果。实施例B2芽后除草作用在温室中，使单子叶和双子叶试验植物在塑料盆中的标准土壤中生长，在4-6叶期，喷施式I试验物质的水悬液(按照WO97/34485中所述方法由25％浓度的可湿性粉剂(实施例F3，b)制备)或喷施式I试验物质的乳液(按照WO97/34485中所述方法由25％浓度乳油(实施例F1，c)制备)，相当于2kg活性组份/公顷或250g活性组分/公顷(500升水/公顷)施用量。随后将受试植株在温室中于最佳条件下培育。18天试验期后，按照9级制对试验进行评价(1＝全部损伤，9＝没有作用)。1-4级(特别是1-3级)表示具有良好至很好的除草作用。在本试验中，式I的化合物表现出强有效的除草作用。表B2a芽后作用化合物 g/ha 番薯 黑麦草狗尾草 白芥 茄 繁缕A2-B1 2000121 112A2-B10822000122 112A2-B10832000142 112A2-B90 2000122 122A2-B68 2000122 112A2-B24 2000122 122A2-B73 2000132 112A2-B75 2000223 122A2-B95 2000122 122A2-B93 2000122 122A3-B1 2000132 112A94-B1 2000122 111A2-B10632000224 122A2-B10612000222 122A2-B133 2000122 122A2-B10582000124 122A64-B24 2000224 122A64-B1 2000234 112A2-B10892000122 112A2-B31 2000222 122A2-B10902000244 222A2-B46(顺式)2000123 122A2-B46(反式)2000122 112A2-B91 2000122 122A2-B2 2000122 122化合物 g/ha 番薯 黑麦草 狗尾草 白芥 茄 繁缕A2-B29 20002 32 122A2-B106620001 32 122A2-B25 20001 22 212A2-B106820001 24 112A2-B107020002 42 222A2-B5 20001 22 122A2-C149 20001 32 122A2-C146 20001 22 122A2-B112 20002 32 122A2-B354 20002 22 222A2-E16 20002 32 222A6-B24 20001 32 112A34-B1 20001 22 112A9-B1 20002 42 222A184-B1 20001 32 122A184-B2420001 22 122A7-B24 20001 22 122A3-B24 20002 22 122A34-B24 20001 22 122A8-B24 20002 22 122A18-B24 20001 22 122A2-C152 20002 23 122A2-B69 20001 22 122A2-D36 20002 22 122A2-B618 20002 22 122A2-B49 20002 22 122A2-B109320002 22 122A2-B33 20002 42 122A2-B34 20001 32 112A2-B35 20001 32 112A2-B108720001 43 122A531-B2420002 22 122A2-B109520001 24 122化合物 g/ha 番薯 黑麦草 狗尾草白芥 茄 繁缕A2-C147 200012 2122A2-B70 200034 3122A2-B49 200022 2122A2-C1200032 2122A2-B1100 200022 3112A8-B2200022 2223A8-B1064 200024 2112A8-B133 200024 2122A8-B1101 200023 2122A2-B1101 200022 2113A2-B156 200012 2122A2-B134 200022 1112A1210-B354 200022 2112A2-C2200021 1111A2-D36 200021 1111A2-D113(Isom.A) 200021 1112A2-D113(Isom.B) 200022 2212A2-D114 200021 1111A2-D115 200012 1111A8-B34 200022 2222A8-B1103 200014 1111A2-C24 200011 1111表B2b芽后作用化合物 稷 马唐 稗 苘麻 苍耳 Ipopur.藜g/haA8-B1 2504333332A2-B1091 2504423433A2-B1094 2502323332A2-B1452502223331A1208-B354 2503421222A1210-B1 2502222221A8-B5522502332222A8-B1562502331221A1210-B11052501232221A8-B1342503332332A8-D36 2503322332A2-D111(顺式) 2502242122A2-D111(反式) 2503333132A8-D1112503333123A8-D1092503333123A8-F5 2504343333A2-F5 2503333343在式I化合物按照WO97/34485的实施例F2及F4-F8所述方法加工配制的情形下，试验得到同样的结果。
权利要求
1.式I化合物或其农药上可耐受的盐M+或式I化合物的立体异构体或互变异构体 其中p为0或1；R5为C1-C6卤代烷基；R2为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，被C1-C2烷氧基羰基或苯基取代的乙烯基，或者为C2-C6炔基，C2-C6卤代炔基，被三甲基甲硅烷基、羟基、C1-C2烷氧基、C1-C2烷氧基羰基或苯基取代的乙炔基，或者为C3-C6二烯基，C3-C6环烷基，被卤素取代的C3-C6环烷基，或者为C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6卤代烷氧基，C3-C6卤代链烯氧基，氰基-C1-C4烷氧基，C1-C4烷氧基-C1-C4烷氧基，C1-C4烷硫基-C1-C4烷氧基，C1-C4烷基亚磺酰基-C1-C4烷氧基，C1-C4烷基磺酰基-C1-C4烷氧基，C1-C4烷氧基羰基-C1-C4烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C4烷氧基羰基-C1-C4烷硫基，C1-C4烷氧基羰基-C1-C4烷基亚磺酰基，C1-C4烷氧基羰基-C1-C4烷基磺酰基，苄基-S(O)n1-，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，二-(C1-C6烷基氨基)磺酰基，苄氧基，苄基，苯基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，这些含苯基的基团本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者R2为OS(O)n2-R21，N(R23)-S(O)n3-R22，氰基，氨基甲酰基，C1-C4烷氧基羰基，甲酰基，卤素，氰硫基，氨基，羟基-C1-C4烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C6烷基羰氧基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4烷氧基羰氧基-C1-C4烷基，C1-C4氰硫基-C1-C4烷基，苯甲酰氧基-C1-C4烷基，C2-C6环氧乙烷基，C1-C4烷基氨基-C1-C4烷基，二-(C1-C4烷基)氨基-C1-C4烷基，C1-C12烷基硫代羰基-C1-C4烷基或甲酰基-C1-C4烷基，或者R2为可以是芳香性或部分饱和并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2SO-、或-CH2SO2基团与吡啶环键连，且每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；R3为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C6烷基氨基，C2-C5二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6二烷基氨基磺酰基，苯基，苯硫基，苯基亚磺酰基，苯磺酰基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者R3为-N(R23)-S(O)n-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基或C1-C4烷基-S(O)n-C1-C4烷基；R4为氢，C1-C6烷基，羟基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6卤代链烯氧基，C3-C6炔氧基，C1-C4烷基羰氧基，C1-C4烷基磺酰氧基，甲苯磺酰氧基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，C1-C4烷基氨基，C1-C4二烷基氨基，C1-C4烷氧基羰基，C1-C4卤代烷基，甲酰基，氰基，卤素，苯基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代；或者R4为可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或R3-稠合二环环系，其中所述环系，除非稠合，均直接或经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2S-、-CH2SO-、或-CH2SO2-基团与吡啶环键连，且所述环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C1-C4烷氧基-C1-C2烷硫基，C1-C4烷基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷硫基，氰基-C1-C4烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；R21为C1-C4烷基或C1-C4卤代烷基；R22为C1-C4烷基，C1-C4卤代烷基或二-(C1-C4烷基)氨基；R23、R24、R25彼此独立地为氢或C1-C4烷基；n，n1，n2，n3和n4彼此独立地为0，1或2；Q为Q1 其中R6、R7、R8和R9彼此独立地为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6炔基，C1-C6烷氧基羰基，C1-C6烷基羰基，C1-C6烷基-S(O)n17，C1-C6烷基-NHS(O)2，C1-C6烷基氨基，二-(C1-C6烷基)氨基，羟基，C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，羟基-C1-C6烷基，C1-C4烷基磺酰氧基-C1-C6烷基，甲苯磺酰氧基-C1-C6烷基，C1-C6烷氧基-C1-C6烷基，C1-C6烷基-S(O)n4-C1-C6烷基，氰基-C1-C6烷基，C1-C6烷氧基-C1-C6烷氧基，苄氧基-C1-C6烷基，C1-C6烷氧基羰基-C1-C6烷基，C1-C6烷氧基羰氧基-C1-C6烷基，氰硫基-C1-C6烷基，环氧乙烷基，C1-C6烷基氨基-C1-C6烷基，二(C1-C6烷基)氨基-C1-C6烷基，甲酰基-C1-C6烷基，C1-C6烷基肟基，卤素，氰基，硝基，苯基或被下列基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n18、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n5、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n19N(C1-C4烷基)2、卤素、硝基、COOH或氰基；或者相邻的R6与R7或R8与R9一起表示-(CH2)m-，C(O)O(CH2)n20-或-S(O)n21(CH2)n22-；n5，n17，n18，n19和n21彼此独立地为0，1或2；n20为2或3；n22为2，3或4；m为2，3，4，5，或6；W为氧，S(O)n6，-CR11R12-，-CR63R64CR65R66，-C(O)-或-NR13；R63、R64、R65和R66彼此独立地为氢或C1-C6烷基，或者R65与R7或R9一起形成直接键；n6为0，1或2；R11为氢，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基，C1-C4烷硫基-C3-C6环烷基，C1-C4烷基羰氧基-C1-C4烷基，C1-C4烷基磺酰氧基-C1-C4烷基，甲苯磺酰氧基-C1-C4烷基，二-(C1-C3烷氧基烷基)甲基，二-(C1-C3烷硫基烷基)甲基，(C1-C3烷氧基烷基)-(C1-C3烷硫基烷基)甲基，C3-C5氧杂环烷基，C3-C5硫杂环烷基，C3-C4二氧杂环烷基，C3-C4二硫杂环烷基，C3-C4氧硫杂环烷基，甲酰基，C1-C4烷氧基羰基，氨基甲酰基，C1-C4烷基氨基羰基，二-(C1-C4烷基)氨基羰基，苯基氨基羰基，苄基氨基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n21、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n7、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n20N(C1-C4烷基)、卤素、硝基、COOH或氰基；n7，n20和n21彼此独立地为0，1或2；或者R12与R6或R9一起代表基团-(CH2)o-；o为1，2，3，4或5；R12为氢，C1-C4烷基或C1-C4卤代烷基；或者R12与R11一起代表基团-(CH2)m1；m1为2，3，4，5，或6；R10为羟基，O-M+，卤素，氰基，SCN，OCN，C1-C12烷氧基，C1-C4烷氧基羰基-C1-C4烷氧基，C1-C12烷硫基，C1-C12烷基亚磺酰基，C1-C12烷基磺酰基，C1-C12卤代烷硫基，C1-C12卤代烷基亚磺酰基，C1-C12卤代烷基磺酰基，C1-C6烷氧基-C1-C6烷硫基，C1-C6烷氧基-C1-C6烷基亚磺酰基，C1-C6烷氧基-C1-C6烷基磺酰基，C2-C12链烯硫基，C2-C12链烯基亚磺酰基，C2-C12链烯基磺酰基，C2-C12炔硫基，C2-C12炔基亚磺酰基，C2-C12炔基磺酰基，C2-C12卤代链烯硫基，C2-C12卤代链烯基亚磺酰基，C2-C12卤代链烯基磺酰基，C1-C4烷氧基羰基-C1-C4烷硫基，C1-C4烷氧基羰基-C1-C4烷基亚磺酰基，C1-C4烷氧基羰基-C1-C4烷基磺酰基，(C1-C4烷氧基)2P(O)O，C1-C4烷基-(C1-C4烷氧基)P(O)O，H(C1-C4烷氧基)P(O)O，R14R15N，R14R15NNH，R16R17NC(O)O-，R16R17NC(O)NH-，C1-C12烷基-S(O)2NR18，C1-C4卤代烷基-S(O)2NR19，C1-C12烷基-S(O)2O，C1-C4卤代烷基-S(O)2O，C1-C18烷基羰氧基，其中的烷基基团可以被卤素、C1-C6烷氧基、C1-C6烷硫基或氰基取代，或者为C2-C18链烯基羰氧基，C2-C18炔基羰氧基，C3-C6环烷基羰氧基，C1-C12烷氧基羰氧基，C1-C12烷硫基羰氧基，C1-C12烷基硫代氨基甲酰基，C1-C6烷基-NH(CS)N(C1-C6烷基)-NH-，二-C1-C6烷基-N(CS)N(C1-C6烷基)-NH-，苄氧基，苄硫基，苄基亚磺酰基，苄基磺酰基，苯氧基，苯硫基，苯基亚磺酰基，苯基磺酰基，苯磺酰基氨基，苯磺酰氧基或苯甲酰氧基，其中的苯基基团部分本身又可被下述基团取代C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷硫基、C1-C4烷基亚磺酰基、C1-C4烷基磺酰基、C1-C4烷基-S(O)2O、C1-C4卤代烷硫基、C1-C4卤代烷基亚磺酰基、C1-C4卤代烷基磺酰基、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；或者R10为基团Ar1-硫基，Ar2-亚磺酰基，Ar3-磺酰基，-OCO-Ar4或NH-Ar5，其中Ar1、Ar2、Ar3、Ar4和Ar5彼此独立地为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，且对于每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中的苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮上的取代基不能为卤素；R14、R15、R16、R17和R18彼此独立地为氢或C1-C6烷基；n8，n9，n10，n11，n12，n13和n14彼此独立地为0，1或2；R13为氢，C1-C4烷基，C1-C4烷硫基-C1-C4羰基，C1-C4烷基亚磺酰基-C1-C4羰基，C1-C4烷基磺酰基-C1-C4羰基，C1-C4烷氧基羰基，C1-C4烷基羰基，苯基羰基，或者为其本身还可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n15、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n16、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；以及n15和n16彼此独立地为0，1或2。
2.根据权利要求1的化合物或其农药上可耐受的盐M+或式I化合物的立体异构体或互变异构体，其中p为0；R5为C1-C6卤代烷基；R2为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，苄基-S(O)n1-，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6-二烷基氨基磺酰基，苯基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者为OS(O)n2-R21，N(R23)-S(O)n3-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基或C1-C4烷氧基-C1-C4烷氧基；R3为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C3-C6环烷基，C1-C6烷氧基，C1-C6卤代烷氧基，C1-C6烷硫基，C1-C6烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷硫基，C1-C6卤代烷基亚磺酰基，C1-C6卤代烷基磺酰基，C1-C6烷基氨基，C2-C6二烷基氨基，C1-C6烷基氨基磺酰基，C2-C6二烷基氨基磺酰基，苯基，苯硫基，苯基亚磺酰基，苯磺酰基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，或者为-N(R23)-S(O)n-R22，氰基，卤素，氨基，C1-C4烷氧基-C1-C4烷基或C1-C4烷基-S(O)n-C1-C4烷基；R4为氢，C1-C6烷基，C1-C4烷氧基，C1-C4卤代烷氧基，C1-C4烷基羰氧基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，C1-C4卤代烷基，甲酰基，氰基，卤素，苯基或苯氧基，其中的苯基部分本身又可以被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代；或者R4为可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或R3-稠合二环环系，其中所述环系经由C1-C4亚烷基与吡啶环键连，且所述环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6卤代链烯基，C2-C6炔基，C2-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C1-C4烷氧基-C1-C2烷硫基，C1-C4烷基羰基-C1-C2烷硫基，C1-C4烷氧基羰基-C1-C2烷硫基，氰基-C1-C4烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，C2-C4二烷基氨基磺酰基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；R21和R22彼此独立地为C1-C4烷基或C1-C4卤代烷基；R23、R24和R25彼此独立地为氢或C1-C4烷基；n，n1，n2，n3和n4彼此独立地为0，1或2；Q为Q1 其中R6、R7、R8和R9彼此独立地为氢，C1-C6烷基，C1-C6卤代烷基，C2-C6链烯基，C2-C6炔基，C1-C6烷氧基羰基，C1-C6烷基-S(O)n17，C1-C6烷基-NHS(O)2，C1-C6烷基氨基，二-(C1-C6烷基)氨基，羟基，C1-C6烷氧基，C3-C6链烯氧基，C3-C6炔氧基，羟基-C1-C6烷基，C1-C4烷基磺酰氧基-C1-C6烷基，甲苯磺酰氧基-C1-C6烷基，卤素，氰基，硝基，苯基或被下列基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n18、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n5、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n19N(C1-C4烷基)、卤素、硝基、COOH或氰基；或者相邻的R6与R7或R8与R9一起表示-(CH2)m-；n5，n17，n18和n19彼此独立地为0，1或2；m为2，3，4，5，或6；W为氧，S(O)n6，-CR11R12-，-C(O)-或-NR13-；n6为0，1或2；R11为氢，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷硫基-C1-C4烷基，C1-C4烷基羰氧基-C1-C4烷基，C1-C4烷基磺酰氧基-C1-C4烷基，甲苯磺酰氧基-C1-C4烷基，二-(C1-C3烷氧基烷基)甲基，二-(C1-C3烷硫基烷基)甲基，(C1-C3烷氧基烷基)-(C1-C3烷硫基烷基)甲基，C3-C5氧杂环烷基，C3-C5硫杂环烷基，C3-C4二氧杂环烷基，C3-C4二硫杂环烷基，C3-C4氧硫杂环烷基，甲酰基，C1-C4烷氧基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、氨基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n21、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n7、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)n20N(C1-C4烷基)、卤素、硝基、COOH或氰基；n7，n20和n21彼此独立地为0，1或2；或者R12与R9一起代表基团-(CH2)o-；o为1，2，3，4或5；R12为氢，C1-C4烷基或C1-C4卤代烷基；或者R12与R11一起代表基团-(CH2)m1；m1为2，3，4，5，或6；R10为羟基，O-M+，卤素，C1-C12烷氧基，C1-C12烷基羰氧基，C2-C4链烯基羰氧基，C3-C6环烷基羰氧基，C1-C12烷氧基羰氧基，C1-C12烷基羰氧基，R23R24N-C(O)O，C1-C12烷基S(O)n8-，C1-C4卤代烷基-S(O)n9-，C2-C12-链烯基S(O)n10-，C2-C12卤代链烯基S(O)n11-，C2-C12炔基S(O)n12-；苄氧基，苯氧基，苯硫基，苯基亚磺酰基或苯磺酰基，其中的苯基基团部分本身又可被下述基团取代C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n13、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n14、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基，或者为C1-C4烷基-S(O)2O，苯基-S(O)2O，(C1-C4烷氧基)2P(O)O，C1-C4烷基(C1-C4烷氧基)P(O)O，或H(C1-C4烷氧基)P(O)O；n8，n9，n10，n11，n12，n13和n14彼此独立地为0，1或2；R13为氢，C1-C4烷基，C1-C4烷氧基羰基或其本身又可以被下述基团取代的苯基C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4烷基羰基、C1-C4烷氧基羰基、C1-C4烷基氨基、二-C1-C4烷基氨基、C1-C4烷基-S(O)n15、C1-C4烷基-S(O)2O、C1-C4卤代烷基-S(O)n16、C1-C4卤代烷基-S(O)2O、C1-C4烷基-S(O)2NH、C1-C4烷基-S(O)2N(C1-C4烷基)、卤素、硝基或氰基；n15和n16彼此独立地为0，1或2。
3.根据权利要求1的化合物，其中R10为羟基或O-M+。
4.根据权利要求1的化合物，其中W为氧，-CR11R12-或-C(O)-。
5.根据权利要求1的化合物，其中W为氧，并且R6、R7、R8和R9彼此独立地为氢或C1-C3烷基。
6.根据权利要求1的化合物，其中W为-C(O)-，并且R6、R7、R8和R9彼此独立地为C1-C3烷基。
7.根据权利要求1的化合物，其中R2为氢和R3为甲基。
8.根据权利要求1的化合物，其中R2为甲基，乙基，正丙基，异丙基，乙烯基，甲氧基甲基，甲氧基羰氧基甲基，乙氧基羰氧基甲基，乙酰氧基甲基，丙酰氧基甲基，氯甲基，溴甲基，氟甲基，二氟甲基，三氟甲基或氰基甲基。
9.根据权利要求1的化合物，其中R4为氢或甲基。
10.根据权利要求1的化合物，其中R5为三氟甲基，二氟氯甲基，五氟乙基，七氟丙基或二氟甲基。
11.根据权利要求1的化合物，其中R3为氢，并且R2为C1-C4烷基，C1-C3卤代烷基，环丙基，C2-C3链烯基，C2-C3卤代链烯基，C2-C3炔基，丙二烯基，C1-C2烷氧基-C1-C2烷基，C1-C2烷硫基-C1-C2烷基，氰基-C1-C2烷基，C1-C2烷氧基羰基-C1-C2烷基，C1-C4烷基羰氧基-C1-C2烷基，C1-C3烷氧基，C1-C3卤代烷氧基，烯丙氧基，炔丙氧基，C1-C3烷硫基，C1-C3烷基亚磺酰基或氰基。
12.式IIIa化合物 其中R501为C1-C6卤代烷基；R301为氢；R401为氢或C1-C6烷基；并且R201为C1-C6烷基，C1-C6卤代烷基-C1-C4烷基，C2-C6链烯基，C2-C6卤代链烯基，或C1-C2烷氧基羰基-或苯基-取代的乙烯基，C2-C6炔基或C2-C6卤代炔基；或者为三甲基甲硅烷基-、羟基-、C1-C2烷氧基-、C1-C2烷氧基羰基-或苯基-取代的乙炔基，或C3-C6二烯基；或者为C3-C6环烷基，卤代C3-C6环烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4氰硫基，环氧乙烷基，C1-C4烷基氨基-C1-C4烷基，C1-C4二烷基氨基-C1-C4烷基，羟基-C1-C4烷基，C1-C12烷硫基羰基-C1-C4烷基或甲酰基-C1-C4烷基，或者R201为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2S-、-CH2SO-或-CH2SO2-基团与吡啶环键连，且每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；以及X为卤素或氰基。
13.式XVIa化合物 其中R501为C1-C6卤代烷基；R301为氢；R401为氢或C1-C6烷基；并且R201为C1-C6烷基，C1-C6卤代烷基-C1-C4烷基，C2-C6链烯基，C2-C6卤代链烯基，或C1-C2烷氧基羰基-或苯基-取代的乙烯基，C2-C6炔基或C2-C6卤代炔基；或者为三甲基甲硅烷基-、羟基-、C1-C2烷氧基-、C1-C2烷氧基羰基-或苯基-取代的乙炔基，或C3-C6二烯基；或者为C3-C6环烷基，卤代C3-C6环烷基，C1-C4烷氧基-C1-C4烷基，C1-C4烷基-S(O)n4-C1-C4烷基，氰基-C1-C4烷基，C1-C4烷氧基羰基-C1-C4烷基，C1-C4氰硫基，环氧乙烷基，C1-C4烷基氨基-C1-C4烷基，C1-C4二烷基氨基-C1-C4烷基，羟基-C1-C4烷基，C1-C12烷硫基羰基-C1-C4烷基或甲酰基-C1-C4烷基，或者R201为可以是芳香性或部分饱和的并且可以含有1-4个选自氮、氧和硫的杂原子的5-10元单环或稠合二环环系，所述环系经由C1-C4亚烷基、-CH＝CH-、-C≡C-、-CH2O-、-CH2N(C1-C4烷基)-、-CH2S-、-CH2SO-或-CH2SO2基团与吡啶环键连，且每一环系不能含有多于2个的氧原子和多于2个的硫原子，并且所述环系本身还可以被下列基团单-、二-或三取代C1-C6烷基，C1-C6卤代烷基，C3-C6链烯基，C3-C6卤代链烯基，C3-C6炔基，C3-C6卤代炔基，C1-C6烷氧基，C1-C6卤代烷氧基，C3-C6链烯氧基，C3-C6炔氧基，巯基，C1-C6烷硫基，C1-C6卤代烷硫基，C3-C6链烯硫基，C3-C6卤代链烯硫基，C3-C6炔硫基，C2-C5烷氧基烷硫基，C3-C5乙酰基烷硫基，C3-C6烷氧基羰基烷硫基，C2-C4氰基烷硫基，C1-C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基磺酰基，氨基磺酰基，C1-C2烷基氨基磺酰基，二-(C1-C2烷基)氨基磺酰基，二-(C1-C4烷基)氨基，卤素，氰基，硝基，苯基和苄硫基，其中苯基和苄硫基本身又可以在苯环上被C1-C3烷基、C1-C3卤代烷基、C1-C3烷氧基、C1-C3卤代烷氧基、卤素、氰基或硝基取代，而且杂环中氮原子上的取代基不能为卤素；并且X为卤素或氰基，但条件是当R501为三氟甲基、同时R301和R401均为氢时，则R201不为C1-C6烷基。
14.除草与抑制植物生长的组合物，其包括除草活性量的式I化合物和惰性载体。
15.防治不需要植物的方法，该方法包括对所述植物或其所在环境施用除草活性量的式I活性成分或包含这种活性成分的组合物。
16.抑制植物生长的方法，该方法包括对所述植物或其所在环境施用除草活性量的式I活性成分或包含这种活性成分的组合物。
17.权利要求14的组合物在防治不需要植物生长方面的应用。
全文摘要
式Ⅰ化合物(其中各取代基如权利要求1中定义)及其农药上可耐受的盐M
文档编号C07D401/12GK1333751SQ99815786
公开日2002年1月30日 申请日期1999年12月22日 优先权日1998年12月23日
发明者A·埃德蒙兹, C·卢西, K·塞金杰, A·德麦斯马克, K·昆兹, J·谢策尔 申请人:辛根塔参与股份公司