HLA‑B27同二聚体用于癌症治疗的用途的制作方法

本发明涉及hla-b27开放型构象异构体用于预防或治疗癌症的用途。

人类白细胞抗原(hla)属于典型的主要组织相容性复合体(mhc)蛋白家族。hla复合体有助于免疫系统区分身体自身的蛋白质与由诸如病毒和细菌等外来入侵物产生的蛋白质。人类具有三种主要的mhci类基因，其被称为hla-a、hla-b和hla-c。hla基因有许多可能的变化，允许每个人的免疫系统对广泛的外来入侵物做出反应。某些hla基因具有数百个鉴定版本(等位基因)，其各被赋予特定数字(诸如hla-b27)。紧密相关的等位基因被分类在一起；例如，至少40个非常相似的等位基因是hla-b27的亚型。这些亚型被指定为hla-b*2701至hla-b*2743。

典型的mhc-i分子(在人类中指定为hla-i)是三聚体结构，其包含与β2-微球蛋白(β2m)和小肽非共价结合的具有三个细胞外结构域(a1、a2和a3)的膜结合重链。hlai重链可以以不与β2-微球蛋白或肽结合的形式存在。这些形式被称为开放型构象异构体。

作为所有其他hla分子，hla-b27的主要功能是将细胞衍生肽呈递给cd8+细胞毒性t淋巴细胞(ctl)，作为适应性免疫应答的一部分。在正常生理条件下，hla-b27分子形成由b27重链、β2-微球蛋白和肽组成的异源三聚体复合体，其源自自身蛋白、病毒或细菌。在这方面，hla-b27类似于所有其他i类hla等位基因。然而，hla-b27还可以作为缺少β2m-微球蛋白和肽的游离重链在细胞中存在，其也称为hla-b27开放型构象异构体。此外，通过在67位(cys67)和164位(cys164)处的半胱氨酸的二硫键形成，hla-b27开放型构象异构体的生化性质还可以诱导无β2m重链同二聚体的形成(antoniou等.，jbc，2003，279，8895-8902)。b27开放型构象异构体的形成不被肽的存在所改变，因此b27开放型构象异构体分子可以结合肽或不结合肽而存在。

b27开放型构象异构体与+hla-b27患者中的脊柱关节炎(spa)的发展有关。hla-b27的拥有与脊柱关节病，患有炎症性肠病(ibd)的患者中的包括强直性脊柱炎(as)、银屑病性关节炎、肠病性关节炎的一组相关疾病，特异性胃肠道和泌尿生殖器感染后的反应性关节炎，以及青少年spa的发展密切相关，最受认可的是as。

b27开放型构象异构体的细胞表面表达的表现导致免疫调节白细胞受体可能与b27开放型构象异构体特异性相互作用的建议。b27开放型构象异构体与免疫调节受体的相互作用如何导致as是尚未确定的。

多种免疫调节受体可识别b27开放型构象异构体(除了t细胞受体(tcr))。所述受体包括杀手免疫球蛋白样受体(kir)和白细胞免疫球蛋白样受体(lilr)，其在多种类型的白细胞上表达，包括nk细胞、nkt细胞、单核细胞、巨噬细胞、dc和t细胞。

癌症是一组以经历不受控制和破坏性生长的身体异常细胞为特征的疾病。肿瘤细胞可以遍布全身并转移而形成肿瘤；这种生长模式被称为恶性。

术语和定义

氨基酸序列从氨基到羧基末端给出。序列位置的大写字母指单字母代码中的l-氨基酸(stryer，biochemistry，第3版，第21页)。

在本说明书的背景下，术语序列同一性和序列同一性的百分比是指通过比较两个比对序列确定的值。序列比对方法是本领域公知的。用于比较序列的比对可通过smith和waterman(adv.appl.math.2：482(1981))的局部同源算法，通过needleman和wunsch(j.mol.biol.48：443(1970))的全局比对算法，通过pearson和lipman(proc.nat.acad.sci.85：2444(1988))的相似性检索或通过这些算法的计算机化实施而进行，其包括但不限于：clustal、gap、bestfit、blast、fasta和tfasta。除非另有说明，本文提供的序列同一性值是指使用利用默认参数的blast程序套件获得的值(altschul等.，j.mol.biol.215：403-410(1990))。用于进行blast分析的软件是公共可得的，例如，通过国家生物技术信息中心(http：//blast.ncbi.nlm.nih.gov/)。用于氨基酸序列比对的一个实例是使用默认设置的blastp算法，如：期望阈值：10；字长：3；查询范围内的最大匹配：0；矩阵：blosum62；空位代价：存在11，延伸1；组成调整：条件性组成得分矩阵调整。用于核酸序列比对的一个所述实例是使用默认设置的blastn算法：期望阈值：10；字长：28；查询范围内的最大匹配：0；匹配/不匹配得分：1.-2；空位代价：线性。

在本说明书的背景下，术语主要组织相容性复合体(mhc)以其在细胞生物学和生物化学领域中已知的含义使用；它是指展示蛋白质的特定部分(肽)的细胞表面分子，也被称为表位。存在两个主要类别的mhc分子：i类和ii类。

mhci类重链分子通常(即，当不是以开放型构象异构体形式时)作为与非mhc分子β2-微球蛋白的单元相连的α链存在。α链在从n末端到c末端的方向上包含信号肽、三个细胞外结构域(α1-3，α1在n末端)、跨膜区和c末端胞质尾。展示或呈递的肽在α1/α2结构域的中心区域被肽结合槽保持。

在本说明书的背景下，术语β2-微球蛋白结构域以其在细胞生物学和生物化学领域中已知的含义使用；它是指作为mhci类异二聚体分子一部分的非mhc分子。换句话说，它组成mhci类异二聚体的β链。

在本说明书的背景下，术语人白细胞抗原(hla)以其在细胞生物学和生物化学领域中已知的含义使用；它是指编码人类mhci类蛋白的基因座。hla中三个主要的mhci类基因是hla-a、hla-b和hla-c，并且所有这些基因都具有不同数量的等位基因，例如hla-b具有3590个已知等位基因。紧密相关的等位基因在某个等位基因的亚组中组合。例如，等位基因hla-b27具有大于160个紧密相关的等位基因，根据hla系统因子who命名委员会，其被标记为hla-b*27:01:00至hla-b*27:99:00。所有已知的hla基因及其各等位基因的全长或部分序列对于本领域技术人员在专业数据库中可得，如imgt/hla(http：//www.ebi.ac.uk/ipd/imgt/hla/)。

在本说明书的背景下，术语抗体以其在细胞生物学和免疫学领域中已知的含义使用；它是指包括但不限于免疫球蛋白g型(igg)、a型(iga)、d型(igd)、e型(ige)或m型(igm)的完整抗体，任何抗原结合片段或其单链及相关或衍生构建体。完整抗体是包含通过二硫键相连的至少两个重(h)链和两个轻(l)链的糖蛋白。每个重链由重链可变区(vh)和重链恒定区(ch)组成。重链恒定区由ch1、ch2和ch3三个结构域组成。每个轻链由轻链可变区(本文中缩写为vl)和轻链恒定区(cl)组成。轻链恒定区由一个结构域cl组成。重链和轻链的可变区包含与抗原相互作用的结合结构域。抗体的恒定区可以介导免疫球蛋白与包括免疫系统的各种细胞(例如，效应细胞)和经典补体系统的第一组分的宿主组织或因子的结合。

在本说明书的背景下，术语可结晶片段(fc)区以其在细胞生物学和免疫学领域中已知的含义使用；它是指包含通过二硫键共价连接的ch2和ch3结构域组成的两个相同的重链片段的抗体部分。

在本说明书的背景下，术语二聚体是指由两个亚基组成的单元。

在本说明书的背景下，术语同二聚体是指由相同的两个亚基或者同一类亚基的高度相似成员的两个亚基组成的二聚体。同二聚体的一个实例是从hla-b27等位基因列表中独立选择的两个亚基组成的二聚体。在某些实施方式中，同二聚体由两个相同的hla-b27等位基因组成。

在本说明书的背景下，术语氨基酸接头是指可变长度的多肽，其用于连接两个多肽以产生单链多肽。对实施本文指定的本发明有用的接头的示例性实施方式是由1、2、3、4、5、10、20、30、40或50个氨基酸组成的寡肽链。氨基酸接头的非限制性实例是连接hla-b27多肽与fc结构域的多肽ggggsggggs(seqidno173)。

本发明提供了用于治疗癌症的hla-b27开放型构象异构体。

根据本发明的一个方面，提供了用于治疗或预防癌症的分离的hla-b27蛋白同二聚体(开放型构象异构体蛋白)。

在某些实施方式中，hla-b27开放型构象异构体同二聚体包含两个相同的hla-b27多肽链。在某些实施方式中，hla-b27蛋白同二聚体包含两个不同的hla-b27多肽链。

根据本发明第一方面的替代方案，提供了用于治疗或预防癌症的hla-b27开放型构象异构体融合蛋白同二聚体。所述融合蛋白同二聚体包含两个单体或者由两个单体组成，且各单体独立于任何其他单体地包含hla-b27链，和已知在体内代谢稳定多肽的多肽结构域。所述稳定结构域的一个实例是免疫球蛋白的fc(可结晶片段)结构域。可选地，hla-b27链和稳定结构域可以通过氨基酸接头连接。此后，包含hla-b27链和免疫球蛋白fc片段的开放型构象异构体融合蛋白在本文中称为hla-b27fc开放型构象异构体或b272-fc。

在某些实施方式中，fc结构域存在于融合蛋白中以增加溶解度、稳定性、亲合力、半衰期，并且从技术角度来看，在哺乳动物系统中是成本有效的生产和纯化(蛋白a或g纯化)。

在某些实施方式中，产生hla-b27开放型构象异构体同二聚体，其没有fc区并与生物素化识别序列偶联，导致其在培养的合成过程中的生物素化。所得产物包含生物素部分。在某些实施方式中，多个hla-b27融合蛋白同二聚体偶联于底物，底物例如但不限于链霉亲和素包被的珠。这种多聚化提高了hla-b27开放型构象异构体在体外测试中的稳定性。在某些实施方式中，通过与链霉亲和素包被的珠结合将四个hla-b27开放型构象异构体同二聚体组装成四聚体(b272-tet)。

在某些实施方式中，hla-b27开放型构象异构体同二聚体另外包含肽表位片段。

根据本发明的第二方面，提供了用于治疗或预防癌症的hla-b27开放型构象异构体单体(即，未连接到第二hla-b27重链多肽，并且未被β2-微球蛋白结合的hla-b27)。在此方面的某些实施方式中，hla-b27单体另外包含肽表位片段。

此方面可归纳为如下条款：

条款1：一种用于治疗或预防癌症的分离的单hla-b27重链多肽单体，其基本上不含相关的β2-微球蛋白。

条款2：如条款1所述的用于治疗或预防癌症的分离的单hla-b27重链多肽单体，其中，所述单体另外包含肽表位片段。

条款3：如条款1或2所述的用于治疗或预防癌症的分离的单hla-b27重链多肽单体，其中，所述hla-b27链仅由hla-b27α1、α2和α3结构域组成。

条款4：如前述条款中任一项所述的用于治疗或预防癌症的分离的单hla-b27重链多肽单体，其中，所述hla-b27链包含跨膜结构域并且不包含细胞内结构域(胞质尾)。

条款5：如前述条款中任一项所述的用于治疗或预防癌症的分离的单hla-b27重链多肽单体，其中，所述hla-b27链与由连续编号的seqidno006至seqidno172的seqidno识别的序列中的任一序列具有≥70％、≥80％、≥85％、≥90％、≥92％、≥93％、≥94％、≥95％、≥96％、≥97％或≥98％、或100％的序列同一性。

条款6：一种组合药物，其包含：

a.如条款1～5中任一项所述的分离的单hla-b27重链多肽单体，和

b.检查点抑制剂。

条款7：如条款6所述的组合药物，其中，所述检查点抑制剂选自ctla4与cd80或cd86相互作用的抑制剂，pd-1与其配体pd-l1、和配体tim-3相互作用的抑制剂，特别是抗ctla4、cd80、cd86、pd-1、pd-l1或tim-3中的任一种的抗体，更特别是抗人类ctla4或pd-1的单克隆抗体。

在本发明上述任一方面的某些实施方式中，所述肽表位片段与hla-b27肽链的抗原呈递结构域内的多肽非共价连接。

在本发明上述任一方面的某些实施方式中，hla-b27链仅包含细胞外hla-b27α1、α2和α3结构域。在这些实施方式中，为了允许在重组细胞中细胞外表达分子，不包含hla-b27链的跨膜结构域和细胞内结构域。

在本发明上述任一方面的某些实施方式中，同二聚体的hla-b27链选自hla-b*27:05、hla-b*27:02、hla-b*27:04、hla-b*27:01、hla-b*27:03、hla-b*27:07、hla-b*27:08、hla-b*27:10、hla-b*27:13、hla-b*27:14、hla-b*27:15、hla-b*27:19、hla-b*27:23、hla-b*27:24、hla-b*27:25或hla-b*27:49。

在本发明上述任一方面的某些实施方式中，hla-b27链仅包含下述序列的hla-b27α1、α2和α3结构域，但是不包含跨膜结构域和细胞内结构域，所述序列选自hla-b*27:05、hla-b*27:02、hla-b*27:04、hla-b*27:01、hla-b*27:03、hla-b*27:07、hla-b*27:08、hla-b*27:10、hla-b*27:13、hla-b*27:14、hla-b*27:15、hla-b*27:19、hla-b*27:23、hla-b*27:24、hla-b*27:25或hla-b*27:49。

hla-b*27:05是分布最广的疾病相关的等位基因。然而，其他其他常见的疾病相关亚型包括但不限于，hla-b*27:02(地中海人群)和hla-b*27:04(中国和其他亚洲人群)，其他的hla-b*27:01、hla-b*27:03、hla-b*27:07、hla-b*27:08、hla-b*27:10、hla-b*27:13、hla-b*27:14、hla-b*27:15、hla-b*27:19、hla-b*27:23、hla-b*27:24、hla-b*27:25和hla-b*27:49也设想用于本发明。由于已经观察到至少一个以上脊柱关节炎患者具有这些亚型，所以这些类型也被认为是疾病相关的。

在本发明上述任一方面的某些实施方式中，hla-b27链与seqidno006至172中的任一个具有≥70％、≥80％、≥85％、≥90％、≥92％、≥93％、≥94％、≥95％、≥96％、≥97％或≥98％、或100％的序列同一性。

在某些实施方式中，hla-b27开放型构象异构体同二聚体或hla-b27融合蛋白同二聚体由独立地选自上述hla-b27等位基因的两个亚基组成。在某些实施方式中，同二聚体由两个相同的hla-b27等位基因组成。

在某些实施方式中，hla-b27融合蛋白同二聚体包含fc结构域。在某些具体的实施方式中，fc结构域包含来自免疫球蛋白g型(igg)、a型(iga)、d型(igd)、e型(ige)或m型(igm)的重链恒定区ch2和ch3。

在某些实施方式中，hla-b27融合蛋白同二聚体包含将稳定结构域(特别是fc结构域)与hla多肽连接的氨基酸接头。在某些具体的实施方式中，所述氨基酸接头包含1个～50个氨基酸，特别是5个～40个氨基酸，更特别是10个～30个氨基酸，甚至更特别是15个～25个氨基酸，所述接头将hla-b27链与fc结构域连接为一个单多肽链。

根据本发明的第三方面，提供了用于处理或治疗癌症的编码本发明上述方面的hla-b27开放型构象异构体单体或融合蛋白单体的核酸分子。在体内来自核酸分子的融合蛋白的表达将在二聚化后产生本发明的融合蛋白多肽。在患者体内从编码它们的核酸表达药物活性多肽的概念是众所周知的，并且可以赋予患者显著的益处。

在某些实施方式中，核酸分子编码包含肽表位片段的hla-b27融合蛋白单体。在某些实施方式中，核酸分子编码仅包含细胞外hla-b27α1、α2和α3结构域的hla-b27融合蛋白单体。在某些实施方式中，核酸分子编码仅包含细胞外hla-b27α1、α2和α3结构域，和肽表位片段的hla-b27融合蛋白单体。

在某些实施方式中，核酸分子编码包含氨基酸接头和/或fc(可结晶片段)结构域的hla-b27融合蛋白单体，并且用于癌症的处理和治疗。

根据本发明的第四方面，提供了用于癌症的处理和治疗的包含本发明第三方面的核酸分子的重组表达载体。

在某些实施方式中，重组表达载体是包含在哺乳动物细胞中(特别是在人细胞中)可操作的启动子的质粒。启动子可操作地连接到本发明的核酸分子。

根据本发明的另一方面，提供了用于癌症的处理和治疗的包含本发明第三方面的核酸分子的病毒。核酸分子是在哺乳动物细胞中(特别是在人细胞中)的可操作的启动子序列的控制下。在某些实施方式中，病毒是腺病毒、腺相关病毒、疱疹病毒或慢病毒。

根据本发明的另一方面，提供了包含本发明第三方面的核酸分子的体外遗传修饰的宿主细胞。

本发明的另一方面提供了本发明第一和第二方面的hla-b27开放型构象异构体同二聚体或融合蛋白同二聚体在制造用于治疗或预防癌症的药物中的用途。

根据另一方面，本发明提供了一种癌症的治疗方法，其包括对有需要的患者施用本发明第一和第二方面的hla-b27开放型构象异构体。

根据本发明的另一方面，提供了一种组合药物，其中，所述组合药物包含：

-本发明上述方面或实施方式中的任一种的hla-b27开放型构象异构体同二聚体或融合蛋白，

及

-免疫检查点抑制剂，其选自细胞毒性t淋巴细胞相关蛋白4(ctla4；也称为cd152)与cd80或cd86相互作用的抑制剂，程序性细胞死亡蛋白1(pd-1；也称为cd279)与其配体pd-l1及t细胞免疫球蛋白和含粘蛋白结构域3(tim-3)的配体相互作用的抑制剂。

在某些实施方式中，免疫检查点抑制剂是ctla4与cd80或cd86相互作用的抑制剂。

在某些实施方式中，免疫检查点抑制剂是依匹木单抗(ipilimumab)(yervoy；casno.477202-00-9)。

在某些实施方式中，hla-b27开放型构象异构体同二聚体或融合蛋白hla-b27同二聚体作为胃肠外剂型提供，特别是制成糖膏剂用于注射。在某些实施方式中，免疫检查点抑制剂作为胃肠外剂型提供，特别是制成糖膏剂用于注射。在某些实施方式中，hla-b27同二聚体和免疫检查点抑制剂以相同的施用形式存在。

在另一方面中，本发明涉及产生重组hla重链多肽的方法。该方法归纳为如下条款：

条款a：通过重组生物技术的方法产生人类hla重链多肽的方法，其中所述方法包括以下步骤：

a.表达步骤：使

i.在细胞(特别是真核细胞，更特别是哺乳动物细胞)中可操作的启动子序列的控制下的至少编码hla重链的α1链、α2链和α3链的hla-编码核酸序列，及

ii.在所述细胞(与条款1.a.中相同的细胞)中可操作的启动子序列的控制下编码人类hlaβ2微球蛋白(uniprotp61769)的β2-微球蛋白编码核酸序列

在哺乳动物细胞(“产生细胞系”)中共表达；

b.纯化步骤：从哺乳动物细胞(产生细胞系)中纯化所得hla-重链/β2-微球蛋白复合体；

c.解离步骤：在合适的条件下解离纯化的hla-重链/β2-微球蛋白复合体，并且从β2-微球蛋白多肽中分离hla重链多肽；

d.重折叠步骤：分离的hla重链多肽在导致(在生理活性的hla开放型构象异构体分子中发现的天然三级蛋白结构的)重折叠的条件下温育。

条款b：如条款a所述的产生人类hla重链多肽的方法，其中，hla-编码核酸序列从编码多肽的n末端到c末端包含α1链、α2链、α3链和稳定序列。

条款c：如条款b所述的产生人类hla重链多肽的方法，其中，稳定序列选自牛血清白蛋白和免疫球蛋白恒定片段(fc)，特别是免疫球蛋白g恒定片段，更特别是igg4fc。

条款d：如前述条款中任一项所述的产生人类hla重链多肽的方法，其中，hla-编码核酸序列和β2-微球蛋白编码核酸序列存在于相同的核酸载体分子上(特别是，dna表达质粒)。

条款e：如前述条款a～c中任一项所述的产生人类hla重链多肽的方法，其中hla-编码核酸序列和β2-微球蛋白编码核酸序列存在于不同的核酸载体分子上(特别是，不同的dna表达质粒)。

条款f：如条款e所述的方法，其中，相对于包含β2-微球蛋白编码核酸序列的核酸载体，包含hla-编码核酸序列的核酸载体以超过大约1倍至5倍，特别是超过1.5倍至5倍，特别是超过大约3倍而存在。

条款g：如前述条款中任一项所述的方法，其中，hla-编码核酸序列包含免疫球蛋白fc片段作为稳定序列，且纯化步骤通过将重组hla重链多肽吸附到与蛋白a连接的表面而实现。

条款h：如前述条款中任一项所述的方法，其中，解离步骤通过在酸性条件下、特别是在大约ph2的条件下进行处理，，并在还原条件下进行透析而实现。

条款i：如前述条款中任一项所述的方法，其中，重折叠步骤通过在中性条件下的处理而实现。

在本文的任何位置将例如等位基因或编码序列等单个可分离特征的替代方式作为“实施方式”列出时，应当理解的是，这些替代方式可以自由组合以形成本文公开的本发明的离散实施方式。

本发明通过以下实施例和附图进一步说明，从中可以得出其他实施方式和优点。这些实施例意在说明本发明，但不限制本发明的范围。

附图说明

图1显示b272-tet阻断cd4⁺t细胞转化为itreg。b272-tet与初始cd4⁺t细胞的温育阻断向itregs(foxp3)的转化。对照四聚体证明了b272-tet对itreg诱导的特异性影响。

图2显示b272-tet以剂量依赖性方式损害鼠和人类tregs的抑制作用。a)b272-tet(2μg/200μl)阻断小鼠itregs的抑制，并允许cd8⁺t细胞的增殖。对照hla-b27和bsa不改变itregs的抑制功能。b)b272-tet(2μg/200μl)阻断人类ntregs的抑制，并允许人类cd8⁺t细胞的增殖。对照hla-b27-tet和hla-b8-tet异三聚体及bsa-tet不改变tregs的抑制功能。c)不同浓度的b272-tet(μg/200μl)对鼠类cd8⁺t细胞的itreg抑制的百分比。d)不同浓度的b272-tet(μg/200μl)对人类cd8⁺t细胞的ntreg抑制的百分比。

图3显示b272调节cd4⁺t细胞的活化。来自大鼠的hla-b27tg和wtcd4⁺t细胞在与b272-tet温育后产生tnf。阻断b272的抗体hd5或hc10的预温育抑制其与cd4⁺t细胞的相互作用和tnf的产生，表明了b272-tet能够单独激活cd4⁺t细胞以产生细胞因子。

图4显示在使用hd5(抗b272抗体)处理的大鼠中来自脾脏和mln的促炎性cd4⁺t细胞扩增的减少。a.使用hla-b27大鼠和hd5注射进行体内研究的时间点。在12周～15周期间的每周，大鼠腹膜内(i.p.)施用10mg/kghd5抗体/大鼠。b-c.就表达tnf(b)和il-17(c)的促炎细胞的存在，通过ics评估获自tg-hd5、tg-ctrl和wt-同窝出生仔畜的体外刺激细胞。在第15周(n＝5)和第23周(n＝5)获得mln和脾脏细胞。结果绘制为tnf、il-17和ifn-γ阳性的cd4⁺t细胞百分比。数值表示为平均值±sem。通过单因素方差分析然后通过bonferronipost-hoc分析确定*p<0.05，**p<0.01，***p<0.005。

图5显示b272-fc和β2mdna盒的的示意图和来自cho细胞的b272-fc分子的表达。a.通过将hla-b27的α1、α2和α3结构域与人类-β2m载体一起插入到人类igg4-fc载体盒而产生b272-β2m-fc复合体，人类-β2m载体是b272-β2m-fc蛋白质的细胞外生产所必需的。b.使用b272-fc-载体+β2m-载体以1:3的比例进行中国仓鼠卵巢细胞(cho)细胞的转染。收集上清液，使用标准抗体纯化方案纯化b272-fc-β2m。

图6显示从b272-β2m-fc复合体分离β2m，并通过sec或透析法纯化和重折叠b272-fc。a)通过sec从superdex200制备级柱纯化的b272-β2m-fc寡聚体和b272-β2m-fc产物的色谱直方图和western印迹分析显示，非变性条件不将β2m与复合体分离，并且形成b272-β2m-fc寡聚物。b)尿素-tris-bme变性缓冲液中的b272-β2m-fc分子的色谱直方图和western印迹显示，通过sec使用sephacryls-100hr柱从β2m解离无b27-fc的重链的。c)使用30kda(5)或50kda(6)的透析膜的在尿素-tris-bme缓冲液中的b272-β2m-fc分子透析从β2m解离无b27-fc的重链。d)通过在重折叠缓冲液中的稀释法和通过hc10(抗无hla重链的单克隆抗体)检测，将无b27-fc的重链重折叠为b272-fc分子。bme＝β-巯基乙醇。b272-fc的大致kda大小＝125kda；无b27-fc的重链＝62.5kda。

图7显示b272-fc注射减少mc38结肠癌小鼠模型中肿瘤的大小。a)结肠癌细胞(mc38-ovadim)的注射时间点和b272-fc注射的实验设计。b)与对照相比，在b272-fc治疗的小鼠中，安乐死后小鼠的肿瘤大小显示肿瘤显著减小。c)在b272-fc治疗的小鼠中，浸润肿瘤的nk细胞的百分比显著更高。d)没有观察到浸润肿瘤的nkt细胞的百分比的显著变化。e)当与同种型比较时，在b272-fc小鼠中观察到浸润肿瘤的treg细胞的百分比没有显著变化，但观察到tregs的量减少的趋势。从不同时间点的两个相同的实验绘制结果。数值表示为平均值±sem。通过单因素方差分析然后通过bonferronipost-hoc分析确定*p<0.05，**p<0.01。

图8显示使用同系模型：pan02鼠类胰腺模型、emt6鼠类乳腺模型和eg.7鼠类淋巴瘤模型，b272-fc与ctla4或pd-1抗体的结合。a)pan02小鼠(n＝6)中的平均肿瘤体积。b)emt6(n＝6)小鼠中的平均肿瘤体积。c)从两个单独的实验中绘出的eg.7小鼠中的平均肿瘤体积。细胞注射时间点和物质注射的实验设计如下：同种型(10mg/kg)q3d×7；b272-fc(10mg/kg)；抗ctla4q3d×3(第一次注射200μg，第二次和第三次注射100μg)；pd-1biwk×3(100μg)；b272-fc+ctla4(分别为q3d×7和q3d×3)，及b272-fc+pd-1(分别为q3d×7和biwk×3)。肿瘤体积表示为平均值±sem，并通过双因素方差分析然后通过bonferronipost-hoc分析，*p<0.05，**p<0.01。q＝注射间的天数；d×＝注射次数，biwk＝每周两次。

实施例

本发明的发明人出乎意料地发现hla-b27开放型构象异构体，特别是当作为包含fc免疫球蛋白片段的融合蛋白存在时，在癌症治疗中可以是有用的。b272-fc分子可以单独使用或与其他癌症治疗剂组合使用。

体外测试

b272-tet分子能够通过影响tregs抑制和体外激活t细胞在人类和啮齿动物中调节免疫应答(图1-3)。

b272-tet阻断鼠类cd4⁺t细胞转化为itregs

分析了hla分子与初始cd4⁺t细胞对itreg转化的影响。在用于itreg转化的最优培养条件下，将0.5μg/ml的b272-四聚体、hla-b27-四聚体和hla-b8-四聚体与初始cd4⁺t细胞进行温育。证明b272-tet下调foxp3的诱导(图1)。

b272-tet通过tregs损害鼠类和人类cd8⁺t细胞的抑制

使用紫色标记的初始cd8⁺t细胞作为应答细胞确定鼠类和人类tregs的抑制功能(图2)。tregs与hla-四聚体和bsa-四聚体共培养，96小时后测量cd8⁺t细胞的增殖。如所预期的单独的cd8⁺t细胞显示出强烈的增殖，当与对照四聚体(hla-b27、hla-b8和bsa)温育时，treg细胞抑制cd8⁺t细胞的增殖。令人震惊的是，在小鼠(图2a)和人类(图2b)抑制测定中，在b272四聚体存在下，通过cd8⁺t细胞的强烈增殖表明tregs的抑制功能受到很大的损害。在小鼠(图2c)和人类(图2d)中，b272-tet的作用是剂量依赖性的。

抗b27开放型构象异构体同二聚体的抗体降低效应cd4⁺t细胞的扩增，并证明b27开放型构象异构体同二聚体在转基因+hla-b27大鼠中的免疫调节作用

为了证明b27开放型构象异构体同二聚体参与到体内疾病中，产生抗b27开放型构象异构体同二聚体的特异性抗体(hd5)。作为体内模型，我们使用spa的hla-b27大鼠模型，其进展为具有升高数量的促炎淋巴细胞(th1、th17、tnf⁺cd4⁺t细胞)的类似人类spa病理学的疾病。来自hla-b27大鼠淋巴细胞的离体数据表明，b272-tet的单独存在能够诱导来自cd4⁺t细胞的促炎细胞因子的表达(图3)。此外，通过注射抗b27开放型构象异构体同二聚体抗体(hd5)(图4a-c)产生的体内结果证明，通过在体内阻断b27开放型构象异构体同二聚体分子，免疫应答被调节，且不同器官中的tnfcd4⁺t细胞(图4b)和th17细胞(图4c)的扩增显著降低。

为了证明b272-fc作为癌症治疗分子的概念证明，进行了使用验证的临床前同系鼠结肠癌模型的实验。

在cho细胞中产生作为人类fc融合蛋白的b27开放型构象异构体

从治疗的角度来说，有效的策略是以稳定的形式(fc融合)产生hla-b27开放型构象异构体分子，以增加溶解性、稳定性、亲合力、半衰期，并且从技术角度来说，在哺乳动物系统中具有成本有效的生产和纯化。通过将b272-β2m-fc蛋白质的细胞外产生所必需的hla-b27的α1、α2和α3结构域与人类-β2m载体一起插入到人类igg4-fc载体盒(图5a)中，成功地产生b272-β2m-fc复合体(图5a，b)。使用b27-fc-载体+β2m-载体以1:3的比例在中国仓鼠卵巢细胞(cho)细胞中进行转染。收集上清液，并且使用标准抗体纯化方案(recombinantproteinpurificationhandbook,principlesandmethods.2009.gehealthcare,18-1142-75)纯化b272-β2m-fc。通过sec或透析方法使用变性条件进行β2m与无b27-fc的重链的分离(图6)。在重折叠缓冲液中使用稀释法评估b272-fc的重折叠，并通过western印迹分析(图6d)。

b272-fc的毒性研究

在6周龄的c57bl/6野生型小鼠中进行毒性研究。以0mg/kg、0.1mg/kg、1mg/kg、10mg/kg的剂量将b272-fci.p.注射到小鼠中，每周两次持续三周。当pbs组与治疗组比较时，未显示一般健康状况的变化(瘫痪、压力、焦虑、无精神症、感染迹象、腹部呼吸、驼背或皱纹毛皮、重量和粪便)。组之间的淋巴细胞群体保持不变，组之间的初始和效应cd4⁺t细胞、cd8⁺t细胞、nk细胞、b细胞和单核细胞在数量没有变化。基于该数据，我们测试10mg/kg的b272-fc用于同系癌症小鼠模型中的体内测试。

b272-fc单一疗法在同系结肠癌小鼠模型中的临床前试验

在治疗情景中进行b272-fc分子(10mg/kg)的注射(图7a)。按照建立的方案，将mc38-ova^dim片段肿瘤皮下注射到同系小鼠的胁腹。一旦肿瘤达到100mm³(注射肿瘤后1周～2周之间)，腹膜内注射b272-fc，每周两次持续三周(图7a)，测量肿瘤大小并分析淋巴细胞的浸润(图7b-e)。

结果表明，与对照相比，b272-fc能够在mc38-ova^dim小鼠中显著降低肿瘤发展(图7b)。与对照相比，通过nk细胞对肿瘤的显著浸润观察b272-fc作用模式的机制效应(图7c)，指出nk细胞是调节肿瘤生长的关键因素的机制。与同种型相比，观察到tregs数量减少的趋势，但不显著(p<0.1)(图7e)。从两个单独的实验绘制结果。

b272-fc与ctla4和pd-1抗体在同系癌症小鼠模型中的临床前联合疗法试验

按照已建立的方案，将pan021×10⁶个细胞、emt61×10⁶个细胞和eg.7×10⁶个细胞分别皮下注射到同系小鼠组的胁腹。根据肿瘤体积(pan02和emt6)或重量(eg.7)分配小鼠。腹膜内注射b272-fc，每三天注射七次(q3d×7)，ctla4以选定的间隔(q3d×7)注射3次(图8)，pd-1注射6次，每周两次(biwk×3)(图8)。

结果表明，当与ctla4单一疗法和同种型对照组相比时，ctla4抗体与b272-fc的组合能够增强ctla4抗体的治疗效果，并显著减少pan02胰腺和emt6乳腺癌模型的肿瘤发展。与pd-1抗体组合的方法的结果显示，当与同种型或载体相比时，b272-fc在eg.7淋巴瘤模型中增加了pd-1抗体的治疗效果(p<0.01)，但pd-1单一疗法不增加。当与同种型或载体相比时，pd-1单一疗法没有显著不同。

结论

使用b272-fc分子对抗癌症的原理证据在不同的同系癌症小鼠模型的临床前实验中得到证实，不论是作为单一疗法或者与ctla4或pd-1抗体的组合疗法。

毒性研究表明，b272-fc疗法没有诱发任何毒性迹象，并且在体内实验过程中，在所述疗法的任何时间点，在治疗组中小鼠的存活都不会受到影响。

在mc38-ova^dim中，我们发现在b272-fc治疗的小鼠中nk细胞浸润到肿瘤微环境中升高。该数据指出，nk细胞通过b272的激活积极参与抗肿瘤响应的机制。因此，b272-fc将被开发并进一步测试为癌症治疗管理中新颖类型的的药物。

b272-fc作为新颖类型的免疫调节药物出现。体外和体内数据表明b272-fc分子作为激活抗肿瘤免疫力的开启机制，最有可能通过改变与免疫检查点相关的机制，或者破坏dc、nk和/或t细胞。

不希望受理论束缚，本发明的发明人假设，b27开放型构象异构体与dc、t细胞和nk细胞的相互作用导致改变的细胞信号传导，以促进参与免疫应答并加剧免疫应答的细胞的存活/扩增。

材料和方法

动物和细胞系

foxp3(egfp)报告小鼠(b6.cg-foxp3^tm2tch/j)获自jackson实验室以用于itreg测定，并在universityhospitalzurich动物设施中饲养。hla-b27/hβ2m转基因(33-3系)(tg)，和野生型(wt)fischerf344雄性大鼠获自taconic(germantown，ny)并在universityhospitalzurich动物设施中饲养。野生型c57bl/6小鼠在universityhospitalbasel动物设施中饲养和保持。mc38-ova^dim是小鼠来源的结肠癌肿瘤细胞系。

体内治疗

将hla-b27/hβ2m转基因(33-3系)(tg)，和野生型(wt)fischerf344雄性大鼠分为三组，并且随机分配为用hd5mab(抗b272)或抗her2neu(对照抗体)治疗，因此：a.wt-同窝出生仔畜(n＝8)，b.tg-hd5(n＝10)，c.tg-ctrl(抗her2neu)对照组(n＝10)。各tg大鼠每周接受腹膜内(i.p.)注射hd5或抗her2neu(ctrl)(10mg/kg)，直至15周龄或23周龄。wt-同窝出生仔畜不接受治疗。

在6周龄的c57bl/6小鼠中进行毒性研究。0mg/kg、0.1mg/kg、1mg/kg、10mg/kg和20mg/kg剂量的b272-fci.p.注射到小鼠中，每周两次持续三周时间。

将mc38-ova^dim肿瘤片段在第6周皮下注射到同系雌性c57bl/6小鼠的右胁腹。一旦肿瘤达到±50mm³，根据其个体肿瘤体积大小分配动物，并将其分为之间无统计学差异的组。在pan02胰腺癌小鼠模型中，将1×10⁶个pan02细胞注射到同系雌性c57bl/6小鼠的胁腹中，根据其肿瘤体积±10mm³分配动物，并将其分为之间无统计学差异的组。在emt6乳腺癌小鼠模型中，将5×10⁶个emt6细胞注射到同系雌性balb/c小鼠的胁腹中，根据其肿瘤体积±40mm³分配动物，并将其分为之间无统计学差异的组。在eg.7淋巴瘤小鼠模型中，将1×10⁶个eg.7细胞注射到同系雌性c57bl/6小鼠的胁腹，根据其体重分配动物，并将其分为之间无统计学差异的组。使用卡尺测量肿瘤直径，根据公式d/2×d2计算体积，其中d和d分别是以毫米为单位的肿瘤的最长直径和最短直径。

如下建立细胞注射时间点和物质注射的实验设计：载体(pbs200μl)；同种型(10mg/kg)q3d×7；b272-fc(10mg/kg)；抗ctla4q3d×3(第一次注射200μg，第二次和第三次注射100μg)；pd-1biwk×3(100μg)；b272-fc+ctla4(分别为q3d×7和q3d×3)，及b272-fc+pd-1(分别为q3d×7和biwk×3)。在mc38-ova^dim模型中通过流式细胞术分析确定肿瘤的大小并分析淋巴细胞的浸润。

动物实验根据瑞士联邦和州的动物保护法进行。

抗体

用以下对淋巴细胞小鼠群体进行染色：cd4(fitc-bdbioscience)、foxp3+(efluor450-ebioscience)、cd3(pe-cy7-ebioscience)、cd45(percp-ebioscience)、cd3(pe-ebioscience)、粒酶b(alexa647，gb11；biol)、nk1.1(bv421-ebioscience)、cd11b(fitc-ebioscience)、cd11c(fitc-ebioscience)和ter119(fitc-ebioscience)。

用以下对淋巴细胞大鼠群体进行染色：cd3(apc-cy7-bd-pharmingen)、cd4(pe-cy7-bd-pharmingen)、il-17a(ebio17b7-apc，ebioscience)、tnf(pe-biolegend)，

用以下对淋巴细胞人类群体进行染色：cd4(pe-biolegend)、foxp3(efluor450-ebioscience)、cd3(apc-cy7-biolegend)。

结合至hla-b和-c等位基因的无β2m的重链和结合至b272的hc10mab(igg2a)受赠于dr.hiddeploegh(mit，ma)。抗b27开放型构象异构体同二聚体的hd5mab(内部，in-house)抗体。小鼠igg1κ同种型对照(biolegend)。抗her2neumab(曲妥珠单抗(trastuzumab)，roche)。抗β2-微球蛋白抗体(abcam)通过western印迹检测人类β2m。

白细胞的流式细胞术

使用1％多聚甲醛进行用于foxp3+treg细胞的检测的细胞内细胞因子染色(ics)，在facs缓冲液中用0.1％皂苷透化，并用一抗(foxp3、cd4和cd3)染色。

在golgiplugtm(bdbioscience)的存在下，使用豆蔻酰佛波醇乙酸酯(pma)和离子霉素(均为0.5μg/ml)进行用于刺激白细胞的细胞内细胞因子染色(ics)5小时。

使用facscantoii(bdbioscience)进行流式细胞术分析，并使用flowjo(版本7.6.4)分析数据。

用于体外测试的hla复合体的产生

在流感核蛋白np383-391肽表位srywairtr(seqidno174)或ebvebna3c表位rriydliel(seqidno175)的存在下，通过具有β2m或不具有β2m的有限稀释将hla-b*2705开放型构象异构体同二聚体和异三聚体复合体重折叠。使用hcmvpp65(tprtgggam；seqidno176)重折叠对照hla-b8异三聚体复合体。使用链霉亲和素或链霉亲和素-pe(lifetechnologies)构建hla四聚体。在对照四聚体和与hla复合体的组合中使用生物素化的bsa(sigma)。

tregs的产生

为了在鼠类cd4⁺t细胞中诱导foxp3表达，我们从f344foxp3^egfp小鼠中收获脾细胞。分选脾细胞以获得cd4⁺t初始细胞。然后将细胞以10⁵个细胞/200μl/孔在包被有5μg/ml的抗cd3mab(ebioscience)、可溶性2μg/ml的抗cd28mab(biolegend)、10μg/ml的tgf-β1(r&dsystems)和100iu/ml的il-2(r&dsystems)的96孔板中培养96小时。

为了扩增人类ntregs，我们首先通过ficoll提取从血沉棕黄层中分离pbmc。然后我们使用regulatorytcelldynabeads试剂盒(invitrogen)分离cd4⁺cd25⁺细胞，并按照手册中的说明，使用humantregexpander试剂盒(invitrogen)进一步扩增它们。细胞在完全rpmi中培养8天，每两天加入500iu的il-2。

在b272四聚体的存在下的itreg诱导

在0.5μg的b272-tet、hla-b27-tet和hla-b8-tet的存在下在用于itreg转化的最优培养条件下温育鼠类初始cd4⁺t细胞72小时。通过流式细胞术测量itreg转化。

抑制测定

cd4⁺或cd8⁺t-效应细胞是从小鼠或人类纯化的pbmc(mousecd4+tcellisolation试剂盒-easysep；flowcomp^tmmousecd8-lifetechnologies；cd8human-lifetechnologies)并用10μm细胞痕量紫增殖染料(分子探针)进行标记。在包被有cd3(ebioscience)(3μg/ml)和可溶性cd28(ebioscience)(1μg/ml)抗体的96孔u-底板中培养tregs(2.5×104)细胞和t-效应细胞(2.5×10⁴)96小时。使用facscantoii测量t-效应细胞的增殖，并使用flowjo(版本7.6.4)的增殖分析软件分析数据。

b272-fc的产生、纯化和重折叠

通过将hla-b27的α1、α2和α3结构域插入到人类igg4-fc载体(invivogen)，以及在单独载体中的人类β2-微球蛋白(β2m)而获得b272-β2m-fc的重组产生。通过将b27-fc-载体和β2m-载体共转染到中国仓鼠卵巢(cho)细胞中而进行重组b272-β2m-fc的产生。b272-β2m-fc的产生外包给evitriaag。

使用常规的抗体纯化方案进行b272-β2m-fc的纯化。通过添加变性步骤从b272-β2m-fc复合体中除去β2m，进行b272-fc的产生。

简单来说，在通过蛋白质-g柱(amershampharmacia)运行上清液(5ml/min)后进行b272-β2m-fc的捕获步骤。通过使用洗脱缓冲液(100mm甘氨酸，ph2.0)从蛋白质g柱中洗脱b272-β2m-fc，并在8m尿素、100mmtris-hclph8.0和5mmβ-巯基乙醇(bme)中回收级分而进行中间纯化步骤。第一精制(polish)步骤是通过使用具有系统(gelifescience)的superdex200制备级或sephacryls-100hr(gelifescience)的任何尺寸排阻色谱法(sec)，或者通过用30kda或50kda孔径的膜(millipore)进行透析，将无b27-fc的重链级分与β2m分离。通过稀释法在无b27的重链的脉冲3次(间隔8小时，每次在100倍体积的重折叠缓冲液(50mmtris-hclph8.5、500mml-精氨酸、1mmedta、0.15mmnacl、1％蔗糖、0.01％聚山梨醇酯-80、1mmgsh和0.1mmgssh)中)后，使从两种方案回收的无b27的重链重折叠。通过sec进行第二精制步骤以进一步除去杂质，将b272-fc分子的新回收级分缓冲液交换成稀释缓冲液(tris50mmph8.0、nacl150mm、1％蔗糖和0.01％聚山梨醇酯-80)中。使用0.2μm膜(millipore)对b272-fc的纯化溶液进行过滤灭菌。

使用hc10(特异性针对无hla的重链)抗体，通过sds聚丙烯酰胺凝胶电泳(sds-page)和western印迹分析b272-β2m-fc复合体和b272-fc级分。在变性条件(10mmdtt)中进行β2m的western印迹。

检查点抑制剂抗体ctla4克隆9h10(eg.7和emt6同系模型中测试的)，ctla4克隆9d9(在pan02同系模型中测试的)和pd-1克隆rmp1-14获自bioxcellco。

hla-b27等位基因的全长和部分序列

hla-b27α链全长的功能性结构域从n末端为c末端为：信号肽，α1，α2，α3(α结构域1-3是加下划线的；α2设置为粗体)，跨膜结构域和胞质尾。

例如，seqidno.8包含：

信号结构域

seqidno.1.mrvtaprtlllllwgavaltetwa，

α1结构域

seqidno.2.gshsmryfhtsvsrpgrgeprfitvgyvddtlfvrfdsdaaspreeprapwieqegpeywdretqickakaqtdrenlrialryynqsea，

α2结构域

seqidno.3.

α3结构域

seqidno.4.dppkthvthhpisdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdrtfqkwaavvvpsgeeqrytchvqheglpkpltlrwepssqstvpiv，

及跨膜结构域和胞质尾

seqidno.5.givaglavlavvvigavvaavmcrrkssggkggsysqaacsdsaqgsdvslta.

seqidno.6.>hla-b2705280aa

seqidno.7.>hla：hla00220b*27:01181aa

seqidno.8.>hla：hla00221b*27:02:01362aa

seqidno.9.>hla：hla06955b*27:02:02181aa

seqidno.10.>hla：hla00222b*27:03362aa

seqidno.11.>hla：hla00223b*27:04:01362aa

seqidno.12.>hla：hla02246b*27:04:02181aa

seqidno.13.>hla：hla03987b*27:04:03181aa

seqidno.14.>hla：hla10469b*27:04:04337aa

seqidno.15.>hla：hla00225b*27:05:02362aa

seqidno.16.>hla：hla00226b*27:05:03181aa

seqidno.17.>hla：hla01179b*27:05:04206aa

seqidno.18.>hla：hla01642b*27:05:05298aa

seqidno.19.>hla：hla01635b*27:05:06181aa

seqidno.20.>hla：hla01985b*27:05:07337aa

seqidno.21.>hla：hla02100b*27:05:08181aa

seqidno.22.>hla：hla02218b*27:05:09181aa

seqidno.23.>hla：hla02826b*27:05:10296aa

seqidno.24.>hla：hla04054b*27:05:11181aa

seqidno.25.>hla：hla04197b*27:05:12181aa

seqidno.26.>hla：hla04509b*27:05:13181aa

seqidno.27.>hla：hla05400b*27:05:14181aa

seqidno.28.>hla：hla05477b*27:05:15181aa

seqidno.29.>hla：hla05925b*27:05:16181aa

seqidno.30.>hla：hla06926b*27:05:17181aa

seqidno.31.>hla：hla07634b*27:05:18362aa

seqidno.32.>hla：hla07901b*27:05:19181aa

seqidno.33.>hla：hla08661b*27:05:20181aa

seqidno.34.>hla：hla08979b*27:05:21181aa

seqidno.35.>hla：hla08980b*27:05:22181aa

seqidno.36.>hla：hla09882b*27:05:23325aa

seqidno.37.>hla：hla09884b*27:05:24181aa

seqidno.38.>hla：hla10198b*27:05:25298aa

seqidno.39.>hla：hla10269b*27:05:26273aa

seqidno.40.>hla：hla11005b*27:05:27181aa

seqidno.41.>hla：hla11226b*27:05:28181aa

seqidno.42.>hla：hla00227b*27:06362aa

seqidno.43.>hla：hla00228b*27:07:01362aa

seqidno.44.>hla：hla07340b*27:07:02273aa

seqidno.45.>hla：hla08329b*27:07:03181aa

seqidno.46.>hla：hla09883b*27:07:04181aa

seqidno.47.>hla：hla00229b*27:08362aa

seqidno.48.>hla：hla00230b*27:09362aa

seqidno.49.>hla：hla00231b*27:10362aa

seqidno.50.>hla：hla08911b*27:100273aa

seqidno.51.>hla：hla09308b*27:101181aa

seqidno.52.>hla：hla09309b*27:102181aa

seqidno.53.>hla：hla09326b*27:103273aa

seqidno.54.>hla：hla09426b*27:104181aa

seqidno.55.>hla：hla09452b*27:105273aa

seqidno.56.>hla：hla09703b*27:106181aa

seqidno.57.>hla：hla10159b*27:107181aa

seqidno.58.>hla：hla10402b*27:108181aa

seqidno.59.>hla：hla10468b*27:109337aa

seqidno.60.>hla：hla00232b*27:11362aa

seqidno.61.>hla：hla10470b*27:110337aa

seqidno.62.>hla：hla10698b*27:111337aa

seqidno.63.>hla：hla10699b*27:112337aa

seqidno.64.>hla：hla10700b*27:113337aa

seqidno.65.>hla：hla10701b*27:114337aa

seqidno.66.>hla：hla10702b*27:115337aa

seqidno.67.>hla：hla10703b*27:116337aa

seqidno.68.>hla：hla10705b*27:117337aa

seqidno.69.>hla：hla10906b*27:118181aa

seqidno.70.>hla：hla11002b*27:119181aa

seqidno.71.>hla：hla00233b*27:12341aa

seqidno.72.>hla：hla11003b*27:120181aa

seqidno.73.>hla：hla11004b*27:121181aa

seqidno.74.>hla：hla11006b*27:122181aa

seqidno.75.>hla：hla11225b*27:123181aa

seqidno.76.>hla：hla11227b*27:124181aa

seqidno.77.>hla：hla11200b*27:125337aa

seqidno.78.>hla：hla11648b*27:126181aa

seqidno.79.>hla：hla11649b*27:127181aa

seqidno.80.>hla：hla11729b*27:128206aa

seqidno.81.>hla：hla11818b*27:129181aa

seqidno.82.>hla：hla00234b*27:13362aa

seqidno.83.>hla：hla12037b*27:130181aa

seqidno.84.>hla：hla12072b*27:131362aa

seqidno.85.>hla：hla00235b*27:14206aa

seqidno.86.>hla：hla00236b*27:15181aa

seqidno.87.>hla：hla01056b*27:16181aa

seqidno.88.>hla：hla01130b*27:17362aa

seqidno.89.>hla：hla01143b*27:18206aa

seqidno.90.>hla：hla01147b*27:19181aa

seqidno.91.>hla：hla01173b*27:20273aa

seqidno.92.>hla：hla01277b*27:21181aa

seqidno.93.>hla：hla01348b*27:23181aa

seqidno.94.>hla：hla01504b*27:24362aa

seqidno.95.>hla：hla01529b*27:25362aa

seqidno.96.>hla：hla01952b*27:26181aa

seqidno.97.>hla：hla02023b*27:27181aa

seqidno.98.>hla：hla02118b*27:28181aa

seqidno.99.>hla：hla02171b*27:29181aa

seqidno.100.>hla：hla02238b*27:30181aa

seqidno.101.>hla：hla02301b*27:31181aa

seqidno.102.>hla：hla02370b*27:32362aa

seqidno.103.>hla：hla02437b*27:33181aa

seqidno.104.>hla：hla02473b*27:34181aa

seqidno.105.>hla：hla02499b*27:35337aa

seqidno.106.>hla：hla02513b*27:36302aa

seqidno.107.>hla：hla02784b*27:37181aa

seqidno.108.>hla：hla02931b*27:38309aa

seqidno.109.>hla：hla03176b*27:39181aa

seqidno.110.>hla：hla03200b*27:40181aa

seqidno.111.>hla：hla03276b*27:41181aa

seqidno.112.>hla：hla03278b*27:42181aa

seqidno.113.>hla：hla03323b*27:43181aa

seqidno.114.>hla：hla03551b*27:44181aa

seqidno.115.>hla：hla03554b*27:45273aa

seqidno.116.>hla：hla03616b*27:46181aa

seqidno.117.>hla：hla03659b*27:47362aa

seqidno.118.>hla：hla03661b*27:48181aa

seqidno.119.>hla：hla03677b*27:49181aa

seqidno.120.>hla：hla03712b*27:50181aa

seqidno.121.>hla：hla03810b*27:51273aa

seqidno.122.>hla：hla03824b*27:52362aa

seqidno.123.>hla：hla03952b*27:53181aa

seqidno.124.>hla：hla03955b*27:54181aa

seqidno.125.>hla：hla04048b*27:55181aa

seqidno.126.>hla：hla04053b*27:56181aa

seqidno.127.>hla：hla04089b*27:57181aa

seqidno.128.>hla：hla04175b*27:58181aa

seqidno.129.>hla：hla04164b*27:59n71aa

shsmryfhtsvsrpgrgeprfitvgyvddtlfvrfdsdaaspreeprapwieqegpeywdretqickakax

seqidno.130.>hla：hla04443b*27:60181aa

seqidno.131.>hla：hla04449b*27:61181aa

seqidno.132.>hla：hla04564b*27:62181aa

seqidno.133.>hla：hla04715b*27:63181aa

seqidno.134.>hla：hla04769b*27:64n127aa

seqidno.135.>hla：hla04771b*27:65n53aa

shsmryfhtsvsrpgrgeprfitvgyvddtlfvrfdsdaaspreeprapwiexseqidno.136.>hla：hla05267b*27:66n213aa

seqidno.137.>hla：hla05404b*27:67273aa

seqidno.138.>hla：hla05268b*27:68298aa

seqidno.139.>hla：hla05269b*27:69337aa

seqidno.140.>hla：hla05473b*27:70181aa

seqidno.141.>hla：hla05492b*27:71181aa

seqidno.142.>hla：hla05504b*27:72181aa

seqidno.143.>hla：hla05517b*27:73181aa

seqidno.144.>hla：hla06183b*27:74181aa

seqidno.145.>hla：hla06212b*27:75181aa

seqidno.146.>hla：hla06230b*27:76181aa

seqidno.147.>hla：hla06255b*27:77181aa

seqidno.148.>hla：hla06256b*27:78181aa

seqidno.149.>hla：hla06292b*27:79181aa

seqidno.150.>hla：hla06353b*27:80181aa

seqidno.151.>hla：hla06940b*27:81181aa

seqidno.152.>hla：hla06993b*27:82181aa

seqidno.153.>hla：hla07187b*27:83181aa

seqidno.154.>hla：hla07188b*27:84181aa

seqidno.155.>hla：hla07177b*27:85181aa

seqidno.156.>hla：hla07339b*27:86181aa

seqidno.157.>hla：hla07441b*27:87181aa

seqidno.158.>hla：hla07631b*27:88181aa

seqidno.159.>hla：hla07689b*27:89181aa

seqidno.160.>hla：hla07902b*27:90:01181aa

seqidno.161.>hla：hla08505b*27:90:02181aa

seqidno.162.>hla：hla11819b*27:90:03181aa

seqidno.163.>hla：hla07903b*27:91181aa

seqidno.164.>hla：hla07932b*27:92181aa

seqidno.165.>hla：hla08327b*27:93181aa

seqidno.166.>hla：hla08330b*27:94n58aa

shsmryfhtsvsrpgrgeprfitvgyvddtlfvrfdsdaaspreeprapwieqegpey

seqidno.167.>hla：hla08331b*27:95181aa

seqidno.168.>hla：hla08332b*27:96:01181aa

seqidno.169.>hla：hla10704b*27:96:02337aa

seqidno.170.>hla：hla08472b*27:97181aa

seqidno.171.>hla：hla08504b*27:98181aa

seqidno.172.>hla：hla08662b*27:99181aa

在所附序列方案中提供了seqidno001至seqidno172的全长和部分序列。

序列表

<110>苏黎世大学

巴塞尔大学

<120>hla-b27同二聚体用于癌症治疗的用途

<130>uz217wo

<160>176

<170>patentinversion3.5

<210>1

<211>24

<212>prt

<213>智人

<400>1

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpala

20

<210>2

<211>90

<212>prt

<213>智人

<400>2

glyserhissermetargtyrphehisthrservalserargprogly

151015

argglygluproargpheilethrvalglytyrvalaspaspthrleu

202530

phevalargpheaspseraspalaalaserproargglugluproarg

354045

alaprotrpilegluglngluglyproglutyrtrpasparggluthr

505560

glnilecyslysalalysalaglnthrasparggluasnleuargile

65707580

alaleuargtyrtyrasnglnsergluala

8590

<210>3

<211>92

<212>prt

<213>智人

<400>3

glyserhisthrleuglnasnmettyrglycysaspvalglyproasp

151015

glyargleuleuargglytyrhisglnaspalatyraspglylysasp

202530

tyrilealaleuasngluaspleusersertrpthralaalaaspthr

354045

alaalaglnilethrglnarglystrpglualaalaargvalalaglu

505560

glnleuargalatyrleugluglyglucysvalglutrpleuargarg

65707580

tyrleugluasnglylysgluthrleuglnargala

8590

<210>4

<211>103

<212>prt

<213>智人

<400>4

aspproprolysthrhisvalthrhishisproileserasphisglu

151015

alathrleuargcystrpalaleuglyphetyrproalagluilethr

202530

leuthrtrpglnargaspglygluaspglnthrglnaspthrgluleu

354045

valgluthrargproalaglyaspargthrpheglnlystrpalaala

505560

valvalvalproserglyglugluglnargtyrthrcyshisvalgln

65707580

hisgluglyleuprolysproleuthrleuargtrpgluproserser

859095

glnserthrvalproileval

100

<210>5

<211>53

<212>prt

<213>智人

<400>5

glyilevalalaglyleualavalleualavalvalvalileglyala

151015

valvalalaalavalmetcysargarglysserserglyglylysgly

202530

glysertyrserglnalaalacysseraspseralaglnglyserasp

354045

valserleuthrala

50

<210>6

<211>280

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(90)

<223>α1

<220>

<221>结构域

<222>(91)..(182)

<223>α2

<220>

<221>结构域

<222>(183)..(280)

<223>α3

<400>6

glyserhissermetargtyrphehisthrservalserargprogly

151015

argglygluproargpheilethrvalglytyrvalaspaspthrleu

202530

phevalargpheaspseraspalaalaserproargglugluproarg

354045

alaprotrpilegluglngluglyproglutyrtrpasparggluthr

505560

glnilecyslysalalysalaglnthrasparggluaspleuargthr

65707580

leuleuargtyrtyrasnglnserglualaglyserhisthrleugln

859095

asnmettyrglycysaspvalglyproaspglyargleuleuarggly

100105110

tyrhisglnaspalatyraspglylysasptyrilealaleuasnglu

115120125

aspleusersertrpthralaalaaspthralaalaglnilethrgln

130135140

arglystrpglualaalaargvalalagluglnleuargalatyrleu

145150155160

gluglyglucysvalglutrpleuargargtyrleugluasnglylys

165170175

gluthrleuglnargalaaspproprolysthrhisvalthrhishis

180185190

proileserasphisglualathrleuargcystrpalaleuglyphe

195200205

tyrproalagluilethrleuthrtrpglnargaspglygluaspgln

210215220

thrglnaspthrgluleuvalgluthrargproalaglyaspargthr

225230235240

pheglnlystrpalaalavalvalvalproserglyglugluglnarg

245250255

tyrthrcyshisvalglnhisgluglyleuprolysproleuthrleu

260265270

argtrpgluproserserglnser

275280

<210>7

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>7

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrtyrarggluasnleuargthrala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>8

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>8

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluasnleuargilealaleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>9

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>9

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>10

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(119)

<223>α1

<220>

<221>结构域

<222>(120)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>10

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

progluhistrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>11

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(119)

<223>α1

<220>

<221>结构域

<222>(120)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>11

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>12

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>12

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>13

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>13

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>14

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>14

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>15

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>15

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>16

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>16

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>17

<211>206

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<400>17

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargala

195200205

<210>18

<211>298

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(298)

<223>α3

<400>18

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrp

290295

<210>19

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>19

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>20

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>20

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>21

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>21

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>22

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>22

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>23

<211>296

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(10)

<223>信号肽

<220>

<221>结构域

<222>(11)..(100)

<223>α1

<220>

<221>结构域

<222>(101)..(192)

<223>α2

<220>

<221>结构域

<222>(193)..(295)

<223>α3

<220>

<221>结构域

<222>(296)..(296)

<223>跨膜

<400>23

glyalavalalaleuthrgluthrtrpalaglyserhissermetarg

151015

tyrphehisthrservalserargproglyargglygluproargphe

202530

ilethrvalglytyrvalaspaspthrleuphevalargpheaspser

354045

aspalaalaserproargglugluproargalaprotrpileglugln

505560

gluglyproglutyrtrpasparggluthrglnilecyslysalalys

65707580

alaglnthrasparggluaspleuargthrleuleuargtyrtyrasn

859095

glnserglualaglyserhisthrleuglnasnmettyrglycysasp

100105110

valglyproaspglyargleuleuargglytyrhisglnaspalatyr

115120125

aspglylysasptyrilealaleuasngluaspleusersertrpthr

130135140

alaalaaspthralaalaglnilethrglnarglystrpglualaala

145150155160

argvalalagluglnleuargalatyrleugluglyglucysvalglu

165170175

trpleuargargtyrleugluasnglylysgluthrleuglnargala

180185190

aspproprolysthrhisvalthrhishisproileserasphisglu

195200205

alathrleuargcystrpalaleuglyphetyrproalagluilethr

210215220

leuthrtrpglnargaspglygluaspglnthrglnaspthrgluleu

225230235240

valgluthrargproalaglyaspargthrpheglnlystrpalaala

245250255

valvalvalproserglyglugluglnargtyrthrcyshisvalgln

260265270

hisgluglyleuprolysproleuthrleuargtrpgluproserser

275280285

glnserthrvalproilevalgly

290295

<210>24

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>24

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>25

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>25

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>26

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>26

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>27

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>27

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>28

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>28

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>29

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>29

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>30

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>30

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>31

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>31

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>32

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>32

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>33

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>33

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>34

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>34

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>35

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>35

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>36

<211>325

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(325)

<223>跨膜和胞质尾

<400>36

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyala

325

<210>37

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>37

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>38

<211>298

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(298)

<223>α3

<400>38

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrp

290295

<210>39

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>39

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>40

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>40

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>41

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>41

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>42

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>42

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyraspglntyralatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>43

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>43

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnsermettyrglycysaspvalgly

115120125

proaspglyargleuleuargglyhisasnglntyralatyraspgly

130135140

lysasptyrilealaleuasngluaspleuargsertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>44

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>44

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>45

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>45

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>46

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>46

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>47

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>47

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargasnleuargglytyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>48

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>48

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnhisalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>49

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>49

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>50

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>50

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspmetglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proglygluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>51

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>51

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalaglnalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>52

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>52

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>53

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>53

serhissermetargtyrphehisthrservalserargproglycys

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proglygluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>54

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>54

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalalaproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>55

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>55

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuhisglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proglygluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>56

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>56

serhissermetargtyrphehisthralametserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

aspglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>57

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>57

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspleuglyproaspglyargleuleuargglytyr

100105110

aspglnseralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>58

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>58

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnargargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>59

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>59

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrargilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>60

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>60

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnsermettyrglycysaspvalgly

115120125

proaspglyargleuleuargglyhisasnglntyralatyraspgly

130135140

lysasptyrilealaleuasngluaspleuargsertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>61

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>61

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluasnleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>62

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>62

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglycysglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

progluhistrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>63

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>63

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalavalserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>64

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>64

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetglytyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>65

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>65

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargglyprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>66

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>66

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglntrpargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>67

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>67

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuhistyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>68

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>68

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasnlysaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>69

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>69

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleulysasnglylysglu

165170175

thrleuglnargala

180

<210>70

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>70

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysthrasnthrglnthrtyrarggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>71

<211>341

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(341)

<223>跨膜和胞质尾

<400>71

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysthrasnthrgln

859095

thrasparggluserleuargasnleuargglytyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysgly

340

<210>72

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>72

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleucysargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>73

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>73

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnarglysglu

165170175

thrleuglnargala

180

<210>74

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>74

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrcysasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>75

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>75

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspargargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>76

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>76

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpseralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>77

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>77

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnargmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglyhisasnglntyralatyraspgly

130135140

lysasptyrilealaleuasngluaspleuargsertrpthralaala

145150155160

aspthralaalaglnileserglnarglysleuglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysasplysleugluargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>78

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>78

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalvalgluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>79

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>79

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisileileglnarg

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

aspglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnaspargalatyrleuglu

145150155160

glyleucysvalgluserleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>80

<211>206

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<400>80

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysaspthrleuglnargala

195200205

<210>81

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>81

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalaasnthrglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>82

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>82

metargvalthrgluproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>83

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>83

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrtrpglnthr

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>84

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>84

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrtyrarggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>85

<211>206

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<400>85

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrtrpglnthrmettyrglycysaspleugly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargala

195200205

<210>86

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>86

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glythrcysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>87

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>87

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysthrasnthrglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>88

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>88

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

progluphetrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>89

<211>206

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<400>89

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnileserlysthrasnthrgln

859095

thrtyrarggluserleuargasnleuargglytyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargala

195200205

<210>90

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>90

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisileileglnarg

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>91

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>91

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proglygluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>92

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>92

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnarg

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

aspglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>93

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>93

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpaspargasnthrgln

505560

ilephelysthrasnthrglnthrtyrarggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>94

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>94

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnsermettyrglycysaspvalgly

115120125

proaspglyargleuleuargglyhisasnglntyralatyraspgly

130135140

lysasptyrilealaleuasngluaspleuargsertrpthralaala

145150155160

aspthralaalaglnileserglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>95

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>95

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglntrpargalatyrleugluglyleucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>96

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>96

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalaglnalaglnthrasparggluserleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>97

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>97

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>98

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>98

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glythrcysvalglutrpleuargarghisleugluasnglylysglu

165170175

thrleuglnargala

180

<210>99

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>99

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ileserlysthrasnthrglnthrtyrarggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>100

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>100

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisileileglnarg

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>101

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>101

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalaglnalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>102

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>102

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnsermettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>103

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>103

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>104

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>104

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

aspglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>105

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>105

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrasnglnphealatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>106

<211>302

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(284)

<223>α3

<220>

<221>结构域

<222>(285)..(302)

<223>跨膜和胞质尾

<400>106

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnileserglnarg

130135140

lysleuglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysasp

165170175

lysleugluargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trpgluproserserglnserthrvalproilevalglyilevalala

275280285

glyleualavalleualavalvalvalileglyalavalval

290295300

<210>107

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>107

serhissermetargtyrphetyrthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>108

<211>309

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(19)

<223>信号肽

<220>

<221>结构域

<222>(20)..(109)

<223>α1

<220>

<221>结构域

<222>(110)..(201)

<223>α2

<220>

<221>结构域

<222>(202)..(304)

<223>α3

<220>

<221>结构域

<222>(305)..(309)

<223>transmembrane

<400>108

proargthrleuleuleuleuleutrpglyalavalalaleuthrglu

151015

thrtrpalaglyserhissermetargtyrphehisthrservalser

202530

argproglyargglygluproargpheilethrvalglytyrvalasp

354045

aspthrleuphevalargpheaspseraspalaalaserproargglu

505560

gluproargalaprotrpilegluglngluglyproglutyrtrpasp

65707580

arggluthrglnilecyslysalalysalaglnthrasparggluasp

859095

leuargthrleuleuargtyrtyrasnglnserglualaglyserhis

100105110

thrleuglnasnmettyrglycysaspvalglyproaspglyargleu

115120125

leuargglytyrhisglnaspalatyraspglylysasptyrileala

130135140

leuasngluaspleusersertrpthralaalaaspthralaalagln

145150155160

ilethrglnarglystrpglualaalaargvalalagluglnleuarg

165170175

alatyrleugluglyleucysvalglutrpleuargargtyrleuglu

180185190

asnglylysgluthrleuglnargalaaspproprolysthrhisval

195200205

thrhishisproileserasphisglualathrleuargcystrpala

210215220

leuglyphetyrproalagluilethrleuthrtrpglnargaspgly

225230235240

gluaspglnthrglnaspthrgluleuvalgluthrargproalagly

245250255

aspargthrpheglnlystrpalaalavalvalvalproserglyglu

260265270

gluglnargtyrthrcyshisvalglnhisgluglyleuprolyspro

275280285

leuthrleuargtrpgluproserserglnserthrvalproileval

290295300

glyilevalalagly

305

<210>109

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>109

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaleuthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>110

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>110

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>111

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>111

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglyhis

100105110

aspglnseralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>112

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>112

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>113

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>113

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnser

859095

mettyrglycysaspvalglyseraspglyargleuleuargglyhis

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leuargsertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>114

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>114

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrtyrarggluserleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>115

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>115

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnargargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>116

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>116

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>117

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>117

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnaspargalatyrleugluglyleucysvalgluserleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisgluvalthr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>118

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>118

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrparggluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>119

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>119

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

pheargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>120

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>120

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalgluserleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>121

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>121

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluglnargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>122

<211>362

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(362)

<223>跨膜和胞质尾

<400>122

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargthrgluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluaspleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargval

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproalagluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

serglyglylysglyglysertyrserglnalaalacysseraspser

340345350

alaglnglyseraspvalserleuthrala

355360

<210>123

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>123

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>124

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>124

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspargargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>125

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>125

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthrvalalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>126

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>126

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaglythralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>127

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>127

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

argtrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>128

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>128

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglncysala

180

<210>129

<211>71

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(71)

<223>α1

<400>129

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaxaa

6570

<210>130

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>130

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglngly

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>131

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>131

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>132

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>132

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glythrcysvalglutrpleuargarghisleugluasnglylysglu

165170175

thrleuglnargala

180

<210>133

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>133

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyleucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>134

<211>127

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(127)

<223>α2

<400>134

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasnxaa

115120125

<210>135

<211>53

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(53)

<223>α1

<400>135

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluxaa

50

<210>136

<211>213

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(213)

<223>α3

<400>136

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalathrtrpargalaseralatrpserglyser

180185190

alaaspthrtrpargthrglyargargargcysseralaargthrpro

195200205

glnarghisthrxaa

210

<210>137

<211>273

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<220>

<221>结构域

<222>(182)..(273)

<223>α3

<400>137

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargmetalaproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargalaaspproprolysthrhisvalthrhishispro

180185190

ileserasphisglualathrleuargcystrpalaleuglyphetyr

195200205

proalagluilethrleuthrtrpglnargaspglygluaspglnthr

210215220

glnaspthrgluleuvalgluthrargproalaglyaspargthrphe

225230235240

glnlystrpalaalavalvalvalproserglyglugluglnargtyr

245250255

thrcyshisvalglnhisgluglyleuprolysproleuthrleuarg

260265270

trp

<210>138

<211>298

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(298)

<223>α3

<400>138

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileseraspleuglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuprolysproleuthrleuargtrp

290295

<210>139

<211>337

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(24)

<223>信号肽

<220>

<221>结构域

<222>(25)..(114)

<223>α1

<220>

<221>结构域

<222>(115)..(206)

<223>α2

<220>

<221>结构域

<222>(207)..(309)

<223>α3

<220>

<221>结构域

<222>(310)..(337)

<223>跨膜和胞质尾

<400>139

metargvalthralaproargthrleuleuleuleuleutrpglyala

151015

valalaleuthrgluthrtrpalaglyserhissermetargtyrphe

202530

histhrservalserargproglyargglygluproargpheilethr

354045

valglytyrvalaspaspthrleuphevalargpheaspseraspala

505560

alaserproargglugluproargalaprotrpilegluglnglugly

65707580

proglutyrtrpasparggluthrglnilecyslysalalysalagln

859095

thrasparggluserleuargthrleuleuargtyrtyrasnglnser

100105110

glualaglyserhisthrleuglnasnmettyrglycysaspvalgly

115120125

proaspglyargleuleuargglytyrhisglnaspalatyraspgly

130135140

lysasptyrilealaleuasngluaspleusersertrpthralaala

145150155160

aspthralaalaglnilethrglnarglystrpglualaalaargglu

165170175

alagluglnleuargalatyrleugluglyglucysvalglutrpleu

180185190

argargtyrleugluasnglylysgluthrleuglnargalaasppro

195200205

prolysthrhisvalthrhishisproileserasphisglualathr

210215220

leuargcystrpalaleuglyphetyrproglygluilethrleuthr

225230235240

trpglnargaspglygluaspglnthrglnaspthrgluleuvalglu

245250255

thrargproalaglyaspargthrpheglnlystrpalaalavalval

260265270

valproserglyglugluglnargtyrthrcyshisvalglnhisglu

275280285

glyleuleulysproleuthrleuargtrpgluproserserglnser

290295300

thrvalproilevalglyilevalalaglyleualavalleualaval

305310315320

valvalileglyalavalvalalaalavalmetcysargarglysser

325330335

ser

<210>140

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>140

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnarg

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>141

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>141

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glythrcysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>142

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>142

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

metasnglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>143

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>143

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserglnthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>144

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>144

serhissermetargtyrphehisthrphevalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>145

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>145

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheileservalglytyrvalaspaspthrglnphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>146

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>146

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

asnglntyralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyleucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>147

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>147

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalaasnthrglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>148

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>148

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnseralatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>149

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>149

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysvaltyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>150

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>150

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserargthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>151

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>151

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrtrpglnthr

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>152

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>152

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalavalthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>153

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>153

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargileala

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysasp

165170175

thrleugluargala

180

<210>154

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>154

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaglnasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>155

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>155

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecysglnalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>156

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>156

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluserleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargglualagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysgly

165170175

thrleuglnargala

180

<210>157

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>157

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluprotrpala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>158

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>158

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluaspleuargthrleu

65707580

leuargtyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

iletyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>159

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)

<223>α1

<220>

<221>结构域

<222>(90)..(181)

<223>α2

<400>159

serhissermetargtyrphehisthrservalserargproglyarg

151015

glygluproargpheilethrvalglytyrvalaspaspthrleuphe

202530

valargpheaspseraspalaalaserproargglugluproargala

354045

protrpilegluglngluglyproglutyrtrpasparggluthrgln

505560

ilecyslysalalysalaglnthrasparggluasnleuargasnleu

65707580

argglytyrtyrasnglnserglualaglyserhisthrleuglnasn

859095

mettyrglycysaspvalglyproaspglyargleuleuargglytyr

100105110

hisglnaspalatyraspglylysasptyrilealaleuasngluasp

115120125

leusersertrpthralaalaaspthralaalaglnilethrglnarg

130135140

lystrpglualaalaargvalalagluglnleuargalatyrleuglu

145150155160

glyglucysvalglutrpleuargargtyrleugluasnglylysglu

165170175

thrleuglnargala

180

<210>160

<211>181

<212>prt

<213>智人

<220>

<221>结构域

<222>(1)..(89)