修饰的脱乙酰氧基头孢菌素c合酶daocs及x射线结构的制作方法

专利名称：修饰的脱乙酰氧基头孢菌素c合酶daocs及x射线结构的制作方法
青霉素和头孢菌素抗生素直接通过发酵或通过修饰含β内酰胺环的源于发酵的物质制备。青霉素和头孢菌生物合成途径被广泛研究并综述(J.E.Baldwin和C.J.Schofield，“β-内酰胺化学”(M.I.Page编)，第1章，Blackie，伦敦1992；Ingolia和Queener，医学研究评论，1989，9，245-264；Aharonowitz，Cohen和Martin，微生物学年述，1992，46，461-495；Schofield，Bycroft，Baldwin，Hadju，Roach，当代结构生物学评论，1997，7，857-864)，包括以下步骤(图1)1．三肽的转化在由异青霉素N合酶(IPNS)催化的步骤中，将L-δ-α-氨基己二酰基-L-半胱氨酰-D-缬氨酸(ACV)转变为异青霉素N。该步骤常见于青霉素和头孢霉素生物合成中。
2．在某些生物中(例产黄青霉(Penicillium Chrysogenum)和构巢曲霉(Aspergillus nidulans))，异青霉素N通过将其L-δ-α-氨基己二酰基侧链与青霉素其它侧链交换而被转化，其中其它侧链通常比异青霉素侧链疏水性更强。此转化由酰胺水解酶/酰基转移催化。由此生物合成过程制备的青霉素的实例包括青霉素G(具一条苯乙酰基侧链)和青霉素V(具一条苯氧乙酰基侧链)。这些疏水青霉素可在适当条件下通过发酵商业生产。
3．在其它生物中(例如带小棒链霉菌(Streptomycesclavuligerus)和枝顶头孢(Cephalosporium acremonium))，异青霉素N被表异构化形成青霉素N。此反应由表异构化酶催化。
4．在某些生物(例如带小棒链霉菌和枝顶头孢)，青霉素N转变为DAOC。此反应在某些生物(例带小棒链霉菌)中由脱乙酰氧基头孢菌素C合酶(DAOCS)催化，在其它生物(例如枝顶头孢)中由脱乙酰氧基/脱乙酰头孢菌素C合酶(DAOC/DACS)催化。
5．在某些生物中(例如带小棒链霉菌和枝顶头孢)DAOC被转变为脱乙酰头孢菌素C(DAC)。在某些生物(例如带小棒链霉菌)中，此反应由脱乙酰头孢菌素C合酶(DACS)催化，在其它生物(例如枝顶头孢)中，由脱乙酰氧基/脱乙酰头孢菌素C合酶(DAOC/DACS)催化。
其它产生其它头孢菌素衍生物的生物合成步骤也可能产生，例如，在枝顶头孢中，DAC可转变为头孢菌素C，在链霉菌中，DAC也可转变为头孢霉素C。催化以上1-6步的每种酶的编码基因已被鉴定并测序。
发酵的青霉素，头孢菌素及它们的生物合成中间体可用作抗生素或制备抗生素中的中间体。具有疏水侧链的青霉素可用于制备头孢菌素或制备头孢菌素中的中间体，例如青霉素(包括青霉素G和青霉素V)可用于制备C-3外亚甲基头孢烯类，此C-3外亚甲基头孢烯在制备商用抗生素，例如头孢克洛(Cefacholr)中可被用作中间体。
酶IPNS，DAOCS，DASC和DAOC/DACS均属利用氧化酶和加氧酶Fe(Ⅱ)扩大家族的成员。该家族中的大部分(包括DAOCS，DACS和DAOC/DACS)利用2-氧化酸(通常为2-酮戊二酸)作为除双氧和主要底物(例如在DAOCS情况下的青霉素N)之外的共底物。因为IPNS不利用2-酮戊二酸，它具有与2-酮戊二酸依赖的加氧酶本质上不同的机制，并且这产生显著不同的活性位点。
本发明本发明基于对DAOCS的三维晶体结构的确定以及源于此的信息和开发工作。X射线坐标提供了关于DAOCS结构中的氨基酸残基间关系的Fe-辅因子和底物与DAOCS的结合方式的详细三给信息。此结构允许对DAOCS和青霉素以及头孢菌素生物合成(包括DACS和DAOC/DACS)的相关酶进行修饰，以改变它们的底物和产物选择性。因为DAOCS结构为2-酮戊二酸依赖的双加氧酶家族第一个发现的结构，它们也可用于该酶家族的新抑制剂的设计。以往曾报道过IPNS与锰结合以及IPNS与铁复合，及ACV的结构的部分综述(Roach等，自然，1995，375，700-704；Roach等，自然，1997，387，827)。如X射线坐标所示，IPNS与锰复合以及与铁，ACV和/或底物类似物形成的复合物的结构曾在Baldwin，Hajdu，Roach，Hensgens，Clifton，GB9621486，1-(加氧酶和方法)中报道。
已开发了制备7-氨基脱乙酰氧基头孢菌素C(7-ADCA)的方法，其中DAOCS基因导入的重组产黄青霉菌株被用于头孢菌素的生产。尤其是如果将己二酸加入这些重组菌株时，产生己二酰基-6-APA，它通过DAOCS转化为己二酰基-7-ADCA，其己二酰基侧链能被除去(EPA-A-0532341，Shibata等，生物医学化学通讯。1996，6，1579-1584)。
IPNS基因序列(及氨基酸序列)与DAOCS，DACS，DAOC/DACS的序列相关但显著不同。可能这些酶的折叠的全部元件(即三维结构中的有效元件)是保守的，而活性位点结构极其显著不同。保守的结构元件可能包括β桶凝胶滚动(′jelly roll′)核和某些α螺旋(包括α螺旋10，如在Roach等，自然，1995，375，700-704中详细说明)。相似的程度不足以确定源自IPNS结构的DAOCS，DACS，或DAOC/DACS的精细结构。至今未有报道基于IPNS结构的DAOCS，DACS，或DAOCS/DACS的模型。一个报导(WO 97/20053)要求对DAOCS中特定残基的修饰得到的产物在改进的青霉素G转变为苯乙酰基(G)-7-氨基头孢菌酸中的应用。
DAOCS的三维结构通过如下所示的X射线坐标确定(结构A)。
以下还显示来自带小棒链霉菌的原核DAOCS与Fe(Ⅱ)和2-酮戊二酸的复合物的高清晰度晶体结构(结构B)。
在一个方面，本发明涉及使用DAOCS结构，以对DAOCS或DACS或DAOC/DACS进行修饰从而使修饰过的酶催化非天然青霉素(例如青霉素G和青霉素V)转化为头孢菌素时，较野生型酶更有效。本发明的另一方面涉及DAOCS结构在微生物中制备非天然产物的应用。这些产物包括异甲叉头孢菌素，它们含或不含α-氨基己二酰基或疏水侧链(例苯乙酰或苯氧乙酰)。因此，本发明一方面涉及使用DAOCS的结构修饰DAOCS(或紧密相关的酶DACS或DAOC/DACS)，旨在(ⅰ)使得酶接受(或更有效接受)非天然青霉素底物以用于新的或具商业价值的抗菌物质的制备。
(ⅱ)使修饰的酶能产生非天然产物(例如异甲叉头孢霉素)或优化少量产物(例3-β-羟基头孢霉素)的制备，以用作抗菌素或商业用化合物制备中的抗菌素或中间体。
另一方面本发明提供应用前面提到的技术得到的被修饰的酶。这些是含重要(如下所详述)序列且与DAOCS结构相似性的酶。因此这些酶的结构可在DAOCS结构基础上进行预测。优选在大多数修饰的酶和DAOCS的主要部分之间存在序列相似性/同一性。以往的序列比较(Roach等，自然，1995，375，700)，采用序列成对比较，然后进行单连锁群分析，显示IPNS，DAOCS，DACS和DAOC/DACS群具有标准差大于5.0(Barton和Sternberg，分子生物杂志，1987，198，327)。数值超过5.0且优选超过6.0意味着所有或多数蛋白二级结构元件中序列顺序正确(Barton，酶学方法，1990，183，403)；因此它们具有大量相似序列和因此而来的结构。注意还有其它标准可用于确定重要序列的相似性，例如具有相似物理化学特性的侧链的氨基酸的同一性或相似性百分比(Barton和Sternberg。分子生物学杂志，1987，198，327)。因此，在序列比较的基础上，能够从其它紧密相关的酶(例DAOCS)预测一种酶(例DACS或DAOC/DACS)的结构。进一步还认识到尽管两种酶可能具有其中大部分或完全保守的二级结构元件的结构，两种酶结构上的区别还可能由形成二级结构元件的氨基酸的侧链造成。改变比较的酶的底物/产物选择性的这些差异造成的影响是可预测的，一旦知晓一种酶的三维结构。
另一方面本发明提供与DAOCS具有显著(如本文定义的)序列相似性的酶，其中青霉素N或DAOC的侧链结合位点被修饰，在以下位点中，至少一个氨基酸残基改变为另一个氨基酸残基或缺失Thr72，Arg74，Arg75，Glu156，Leu158，Arg160，Arg162，Leu186，Ser187，Phe225，Phe264，Arg266，Asp301，Tyr302，Val303，Asn304；和/或至少一个额外氨基酸残基在区域300-311间插入；前提是与以上残基相互作用的其它残基可能被改变，以配合上述之一的改变。
这种类型的修饰允许青霉素V或青霉素G扩展为相应头孢菌素。为实现这目标，与野生型DAOCS相比需要增加突变体的Kcat/Km值，动力学结果说明青霉素N和青霉素G的表观Kcat值相似，但青霉素G的Km值高得多。因此，基于这些分析，DAOCS与青霉素G的结合常数降低应使青霉素G的Kcat/Km比值增加成为可能。
DAOCS的侧链结合袋由肽链不同部分的残基形成，因此可能不只一个残基不得不改变以形成更好的青霉素G/V膨胀。虽然如此，某些残基比其它残基更重要。对DAOCS分子的最后几个C末端残基(Thr308至Ala-311)与晶体结构中其它活性位点之间相互作用的检测表明了，与青霉素核的结合方式，它如附图中图2所示。青核素C-3羧基很可能占据与来自活性位点的对称相关分子的Ala-311类似的位置，与Arg-162和Arg-60形成静电作用。Arg-160的侧链与β-内酰胺羰基形成氢键相互作用。
需要记住，蛋白特异性一般由超过一个氨基酸控制。为了改变蛋白特异性总体上可能需要以下建议的不只一个突变变化，尽管每种突变都起作用。由此而知，优选的用于修饰青霉素的扩展的残基如下a)Arg-266.该残基与天然底物的α-氨基己二酸侧链结合，应转变为更具疏水特性的残基，例Phe，Ala，Val，Leu，Ile。
b)Thr-72.它应转变为疏水残基，例如Val，Leu，Ile，Phe，Ala，以助于青霉素G的疏水侧链结合。与其它突变结合则更有效。
c)Arg-74可有用地转变为中性或疏水残基(Phe，Tyr，Val，Leu，Ile，Ala)。可能额外需要对Arg-75的修饰，因其与Arg74形成氢键网络。
d)Glu-156.此残基与α-氨基己二酸侧链结合。应将其变为Ala，Val，Leu，Ile，Phe，Tyr，Trp，Asn，Gln，Ser中的一个。
e)Leu-158，Asn-301和Tyr-302的侧链形成青霉素侧链结合袋的一部分，并可经有效修饰而更具疏水特性。
f)Asn-304.此残基使酰胺连接侧链与青核素核结合。进行修饰以扩展具截短的或不具侧链的青霉素(例如换为Asp或Glu，形成6-Apa)。
注意其它变化可用于通过氢键或其它相互作用构建部分或全部的侧链结合袋。
DAOCS序列的残基插入或缺失也可用于构建与青霉素侧链的疏水结合袋。疏水残基插入到C末端区域(残基300-311，特别是301-303)，可助于青霉素侧链的疏水结合袋的构建。
另一方面本发明提供与DAOCS具有显著(如本文定义的)序列相似性的酶，其中青霉素N或DAOC的青霉素/头孢菌素结合位点经过修饰，至少一种以下氨基酸残基被改变或缺失Ile88，Arg160，Arg162，Phe164，Met180，Thr190，Ile192，Phe225，Pro241，Val245，Val262，Phe264，Asn304，Ile305，Arg306，Arg307；和/或至少一个额外氨基酸残基插入到区域300-311；前提是与以上残基相互作用的其它残基可能被改变以配合以上的改变。
这方面的进一步讨论见自然第394卷，805-809页，1998，8，20出版，在此收入作为参考文献。
本发明另一方面涉及应用DAOCS的结构，以改变其活性位点(或结构相关的2-酮戊二酸依赖的双加氧酶的活性位点)，从而使修饰的酶接受非β内酰胺底物，生产有价值的氧化化合物。氧化的氨基酸(例如4-羟脯氨酸，羟赖氨酸，羟基天冬氨酸及其它)在有价值物质的生产中可作用合成中间体。运用DAOCS的结构，可靶定特异性残基以用于修饰，以使修饰后的酶可用于生产氧化的氨基酸或肽。此过程可包括对以下残基的修饰。
Arg74，Glu156，Leu158，Arg160，Arg162，Leu186，Ser187，Phe225，Phe264，Arg266，Asp301，Tyr302，Val303，Asn304，Ile88，Arg162，Phe164，Met180，Thr190，Ile192，Pro241，Val245，Val262，Ile305，Arg306，Arg307。
本发明另一方面涉及DAOCS结构在2-酮戊二酸依赖的双加氧酶的选择性抑制剂的设计中的应用。为了提供对纤维化疾病(例如肝硬化，关节炎)的治疗，2-酮戊二酸依赖的双加氧酶脯氨酰4-羟化酶是抑制的靶。但尚无临床使用的抑制剂，很可能是由于难以实现区别于其它酶(包括2-酮戊二酸依赖的酶)的对靶酶的选择性抑制。DAOCS的结构为设计2-酮戊二酸依赖的双加氧酶的抑制剂提供了模板。
以下提供的是来自带小棒链霉菌的DAOCS的2种高清晰度晶体结构无铁脱辅酶的结构(结构A)和与Fe(Ⅱ)及2-酮戊二酸形成的复合体结构(结构B)。结果表明了一种机理，通过该机理酶-Fe(Ⅱ)复合体与2-酮戊二酸和双氧反应以产生活性铁，这是一个许多非血红素加氧酶共有的过程。其它重要的2-氧(代)酸依赖的亚铁酶为参与胶原酶生物合成的脯氨酰基羟化酶，赤霉素3β-羟化酶，它的突变会影响植物茎的长度，和棒烷酸(Clavaminic acid)合酶，该酶参与β-内酰胺酶抑制剂棒烷酸的生物合成。在2-氧代酸依赖性酶家族中，DAOCS属于一个亚族，其成员显示与IPNS和1-氨基环丙烷-1-羧化物氧化酶(乙烯形成酶)具有序列相似性，这些酶在催化过程中不使用2-氧代酸。
DAOCS的无铁形式在空间基团R3情况下以晶体三聚体形式结晶。蛋白主链折叠为保守的具侧螺旋的凝胶滚动核。
坐标和结构因子贮存在蛋白数据库(对于Fe(Ⅱ)-2-酮戊二酸复合体，登记为1rxg和rlrxgsf)。


图1青霉素和头孢霉素的生物合成途径。
图2为DAOCS的活性位点图，显示2-酮戊二酸与铁的结合和建议的青霉素N结合。箭头标出特定氨基酸残基侧链的相互作用。
结构A为DAOCS的三维结构。
结构B为作为与Fe(Ⅱ)和2-酮戊二酸的复合物形式的来自带小棒链霉菌的原核DAOCS的高清晰度晶体结构。
DAOCS的肽序列(使用本文所用的编号)如下所示Met Asp Thr Thr Val Pro Thr Phe Ser Leu 10Ala Glu Leu Gln Gln Gly Leu His Gln Asp 20Glu Phe Arg Arg Cys Leu Arg Asp Lys Gly 30Leu Phe Tyr Leu Thr Asp Cys Gly Leu Thr 40Asp Thr Glu Leu Lys Ser Ala Lys Asp Leu 50Val Ile Asp Phe Phe Glu His Gly Ser Glu 60Ala Glu Lys Arg Ala Val Thr Ser Pro Val 70Pro Thr Met Arg Arg Gly Phe Thr Gly Leu 80Glu Ser Glu Ser Thr Ala Gln Ile Thr Asn 90Thr Gly Ser Tyr Ser Asp Tyr Ser Met Cys 100Tyr Ser Met Gly Thr Ala Asp Asn Leu Phe 110Pro Ser Gly Asp Phe Gly Arg Ile Trp Thr 120Gln Tyr Phe Asp Arg Gln Tyr Thr Ala Ser 130Arg Ala Val Ala Arg Glu Val Leu Arg Ala 140Thr Gly Thr Glu Pro Asp Gly Gly Val Glu 150Ala Phe Leu Asp Cys Glu Pro Leu Leu Arg 160Phe Arg Tyr Phe Pro Gln Val Pro Glu His 170Arg Ser Ala Glu Glu Gln Pro Leu Arg Met 180Ala Pro His Tyr Asp Leu Ser Met Val Thr 190Leu Ile Gln Gln Thr Pro Cys Ala Asn Gly 200Phe Val Ser Leu Gln Ala Glu Val Gly Gly 210Ala Phe Thr Asp Leu Pro Tyr Arg Pro Asp 220Ala Val Leu Val Phe Cys Gly Ala Ile Ala 230Thr Leu Val Thr Gly Gly Gln Val Lys Ala 240Pro Arg His His Val Ala Ala Pro Arg Arg 250Asp Gln Ile Ala Gly Ser Ser Arg Thr Ser 260Ser Val Phe Phe Leu Arg Pro Asn Ala Asp 270Phe Thr Phe Ser Val Pro Leu Ala Arg Glu 280Cys Gly Phe Asp Val Ser Leu Asp Gly Glu 290Thr Ala Thr Phe Gln Asp Trp Ile Gly Gly 300Asn Tyr Val Asn Ile Arg Arg Thr Ser Lys 310Ala 311
结构ACRYST1106.400106.40071.10090.00 90.00 120.00SCALE10.009398 0.005426 0.000000 0.000000SCALE20.000000 0.010852 0.000000 0.000000SCALE30.000000 0.000000 0.014065 0.000000ATOM 1NAMET 131.434 10.641 59.873 0.54244.31ANISOU 1NAMET 18315 2319 6203 -614 -3454 -791ATOM 2CA AMET 130.985 11.769 59.065 0.54239.90ANISOU 2CA AMET 19037 3006 3117 -786 -1026 -296ATOM 3CAMET 130.472 12.900 59.956 0.54228.97ANISOU 3CAMET 14807 3113 3086 -421 -2189 -119ATOM 4OAMET 129.961 12.670 61.055 0.54228.12ANISOU 4OAMET 13925 2381 4377 -402 -1097 74ATOM 5CB AMET 129.970 11.328 58.023 0.54234.85ANISOU 5CB AMET 17877 3692 1672 30 -91-373ATOM 6CG AMET 128.626 12.015 57.903 0.54238.19ANISOU 6CG AMET 17367 4873 2270 133 912-1765ATOM 7SD AMET 127.564 11.232 56.654 0.54247.19ANISOU 7SD AMET 16146 7957 3827 -23441050 -1326ATOM 8CE AMET 128.129 11.973 55.135 0.54227.10ANISOU 8CE AMET 15030 2111 3155 2345 -1467 -9ATOM 9NAASP 230.592 14.105 59.425 0.26830.20ANISOU 9NAASP 24674 3022 3777 -1210-782 -383ATOM 10 CA AASP 229.993 15.322 59.963 0.26834.22ANISOU 10 CA AASP 25567 2803 4633 -1106-964 -525ATOM 11 CAASP 228.494 15.268 59.655 0.26833.34ANISOU 11 CAASP 25665 1997 5006 -314 -1457 877ATOM 12 OAASP 228.099 15.650 58.551 0.26844.76ANISOU 12 OAASP 26859 5248 4901 -1023-1582 1631ATOM 13 CB AASP 230.629 16.528 59.281 0.26825.98ANISOU 13 CB AASP 24424 3085 2361 322 -1794 582ATOM 14 CG AASP 229.978 17.862 59.553 0.26838.05ANISOU 14 CG AASP 26456 2611 5389 -501 -608 -1114ATOM 15 OD1 AASP 228.995 17.937 60.318 0.26842.35ANISOU 15 OD1 AASP 26406 5049179 873 9201991ATOM 16 OD2 AASP 230.449 18.885 58.997 0.26828.59ANISOU 16 OD2 AASP 21619 2901 6341 790 -1022 -253ATOM 17 NBMET 132.709 12.640 58.544 0.45829.49ANISOU 17 NBMET 14552 2218 4435 -105 1580 477ATOM 18 CA BMET 131.874 13.050 57.425 0.45840.62ANISOU 18 CA BMET 14228 4809 6395 580 210103ATOM 19 CBMET 130.884 14.113 57.894 0.45838.21ANISOU 19 CBMET 15082 3637 5797 282 -909 -915ATOM 20 OBMET 130.075 14.599 57.110 0.45844.81ANISOU 20 OBMET 18292 3208 5525 2071 -656 -12ATOM 21 CB BMET 131.131 11.857 56.829 0.45833.14ANISOU 21 CB BMET 14866 2613 5114 2013 -122 818ATOM 22 CG BMET 129.625 11.840 56.968 0.45840.28ANISOU 22 CG BMET 14795 5740 4768 230 -751 53ATOM 23 SD BMET 128.761 11.495 55.422 0.45834.23ANISOU 23 SD BMET 15619 3819 3566 2050 -215 20ATOM 24 CE BMET 129.953 12.079 54.222 0.45854.24ANISOU 24 CE BMET 110672 4519 5420 1149 4083 -2463ATOM 25 NBASP 230.914 14.381 59.194 0.73237.72ANISOU 25 NBASP 24433 3914 5984 -1323-1208 -1385ATOM 26 CA BASP 229.979 15.308 59.811 0.73235.78ANISOU 26 CA BASP 25412 3387 4794 -1064-1050 -795ATOM 27 CBASP 228.536 14.886 59.567 0.73229.66ANISOU 27 CBASP 24876 1624 4771 27 -1561 1218ATOM 28 OBASP 228.181 14.602 58.414 0.73234.65ANISOU 28 OBASP 24375 3689 5100 65 -1485 247ATOM 29 CB BASP 230.195 16.696 59.181 0.732 37.39ANISOU 29 CB BASP 26632 3351 4222 -1850869-1518ATOM 30 CG BASP 229.562 17.730 60.104 0.73230.38ANISOU 30 CG BASP 23243 3791 4510 -500 -606 -1191ATOM 31 OD1 BASP 228.866 17.247 61.030 0.73248.88ANISOU 31OD1BASP 26276 4203 8095 -12033147 -1901ATOM 32OD2BASP 229.760 18.945 59.875 0.73234.85ANISOU 32OD2BASP 22852 3708 6680 -491 444-1450ATOM 33N THR 327.717 14.789 60.606 1.00035.58ANISOU 33N THR 34586 4123 4811 601 -1628 1516ATOM 34CA THR 326.303 14.433 60.495 1.00040.48ANISOU 34CA THR 34650 4555 6175 371 -911 -385ATOM 35C THR 325.382 15.647 60.611 1.00039.82ANISOU 35C THR 34376 4155 6598 320 -3864 -586ATOM 36O THR 324.150 15.556 60.751 1.00033.55ANISOU 36O THR 34668 3107 4972 357 -2748 -588ATOM 37CB THR 325.905 13.450 61.613 1.00039.95ANISOU 37CB THR 33787 4004 7387 160 -1209 62ATOM 38OG1THR 326.591 13.851 62.817 1.00061.83ANISOU 38OG1THR 310134 5882 7476 -4164-3020 2051ATOM 39CG2THR 326.399 12.052 61.278 1.00059.32ANISOU 39CG2THR 34613 3971 13955 1114 -3135 -198ATOM 40N THR 426.036 16.780 60.456 1.00032.55ANISOU 40N THR 44306 4611 3450 377 -2166 -217ATOM 41CA THR 425.439 18.092 60.393 1.00031.22ANISOU 41CA THR 44275 4229 3358 -81 -1179 95ATOM 42C THR 424.672 18.272 59.090 1.00030.06ANISOU 42C THR 44876 3341 3207 773 -1156 -204ATOM 43O THR 425.195 17.935 58.017 1.00031.64ANISOU 43O THR 44877 3780 3363 1935 -1255 -52ATOM 44CB THR 426.510 19.208 60.407 1.00032.31ANISOU 44CB THR 42320 4762 5194 475 -547 593ATOM 45OG1THR 427.324 19.091 61.578 1.00032.36ANISOU 45OG1THR 43705 3955 4635 -79 -797 -389ATOM 46CG2THR 425.852 20.582 60.458 1.00027.22ANISOU 46CG2THR 43728 4174 2443 71 304-151ATOM 47N VAL 523.464 18.796 59.211 1.00021.69ANISOU 47N VAL 54041 1985 2215 -543 -657 158ATOM 48CA VAL 522.690 19.140 58.024 1.00020.42ANISOU 48CA VAL 53675 1964 2120 -622 -517 103ATOM 49C VAL 523.199 20.489 57.499 1.00017.01ANISOU 49C VAL 52263 1803 2396 -279 -622 89ATOM 50O VAL 523.156 21.449 58.252 1.00021.10ANISOU 50O VAL 53662 1885 2472 -389 -656 16ATOM 51CB VAL 521.204 19.216 58.402 1.00024.22ANISOU 51CB VAL 53551 2155 3495 -1045-396 783ATOM 52CG1VAL 520.434 19.700 57.166 1.00020.14ANISOU 52CG1VAL 53202 1779 2672 -453 10 -226ATOM 53CG2VAL 520.701 17.867 58.860 1.00028.58ANISOU 53CG2VAL 55258 2086 3516 -1226431510ATOM 54N PRO 623.750 20.542 56.300 1.00016.95ANISOU 54N PRO 62378 1629 2434 29 -594 301ATOM 55CA PRO 624.354 21.793 55.857 1.00016.90ANISOU 55CA PRO 61645 1775 3000 6-445 303ATOM 56C PRO 623.298 22.800 55.383 1.00015.61ANISOU 56C PRO 61477 1766 2687 -192 -437 545ATOM 57O PRO 622.133 22.432 55.201 1.00015.75ANISOU 57O PRO 61578 1761 2647 -260 -579 55ATOM 58CB PRO 625.216 21.375 54.682 1.00019.85ANISOU 58CB PRO 62320 1752 3468 50 70 182ATOM 59CG PRO 624.632 20.095 54.187 1.00024.76ANISOU 59CG PRO 63550 2953 2904 -1186300-286ATOM 60CD PRO 623.926 19.428 55.357 1.00017.91ANISOU 60CD PRO 61960 1962 2882 -168 -138 -44ATOM 61N THR 723.723 24.031 55.156 1.00014.38ANISOU 61N THR 71518 1567 2378 -158 -616 100ATOM 62CATHR 722.907 25.103 54.6101.000 14.09ANISOU 62CATHR 71625 1554 2174 -255 -581 228ATOM 63C THR 723.605 25.684 53.3741.000 14.74ANISOU 63C THR 71683 1849 2067 -193 -468 121ATOM 64O THR 724.828 25.894 53.4231.000 15.95ANISOU 64O THR 71752 2137 2171 -378 -457 185ATOM 65CBTHR 722.795 26.248 55.6371.000 15.25ANISOU 65CBTHR 71548 1846 2401 56-124 52ATOM 66OG1 THR 722.208 25.717 56.8291.000 16.91ANISOU 66OG1 THR 71818 2149 2458 -402 -183 47ATOM 67CG2 THR 721.952 27.387 55.0401.000 16.09ANISOU 67CG2 THR 71651 1613 2848 -138 -263 -25ATOM 68N PHE 822.830 25.892 52.3251.000 15.06ANISOU 68N PHE 81966 1618 2137 -411 -558 230ATOM 69CAPHE 823.317 26.545 51.1361.000 14.76ANISOU 69CAPHE 81857 1558 2192 -213 -411 281ATOM 70C PHE 822.421 27.728 50.810 1.00014.94ANISOU 70C PHE 81907 1421 2347 -275 -357 181ATOM 71O PHE 821.198 27.678 50.995 1.00016.40ANISOU 71O PHE 81782 1642 2808 -197 -550 34ATOM 72CBPHE 823.242 25.562 49.948 1.00016.49ANISOU 72CBPHE 82123 1854 2287 49-371 -1ATOM 73CGPHE 824.225 24.432 50.027 1.00014.92ANISOU 73CGPHE 81710 1824 2135 -197 -365 163ATOM 74CD1 PHE 823.822 23.227 50.600 1.00016.78ANISOU 74CD1 PHE 81808 1726 2842 -300 -358 184ATOM 75CD2 PHE 825.539 24.558 49.602 1.00016.67ANISOU 75CD2 PHE 81705 2130 2500 -310 -361 321ATOM 76CE1 PHE 824.702 22.183 50.742 1.00016.74ANISOU 76CE1 PHE 82035 1966 2359 -4 -99 295ATOM 77CE2 PHE 826.420 23.525 49.773 1.00019.18ANISOU 77CE2 PHE 81398 2153 3736 -408 -631 187ATOM 78CZPHE 826.026 22.336 50.351 1.00017.90ANISOU 78CZPHE 81849 2003 2948 -119 -376 20ATOM 79N SER 923.023 28.776 50.314 1.00014.82ANISOU 79N SER 92134 1488 2008 -351 -528 310ATOM 80CASER 922.338 29.902 49.715 1.00015.12ANISOU 80CASER 92037 1259 2449 -357 -571 134ATOM 81C SER 921. 97729.607 48.270 1.00016.19ANISOU 81C SER 92138 1791 2224 -374 -535 547ATOM 82O SER 922.877 29.312 47.473 1.00017.04ANISOU 82O SER 92191 1892 2393 -423 -544 232ATOM 83CBSER 923.306 31.113 49.696 1.00018.74ANISOU 83CBSER 92891 1712 2519 -1012 -478 717ATOM 84OGSER 922.738 32.131 48.853 1.00020.82ANISOU 84OGSER 92866 1569 3477 -662 -854 607ATOM 85N LEU 10 20.697 29.674 47.924 1.00016.46ANISOU 85N LEU 10 2215 1495 2542 -228 -740 -48ATOM 86CALEU 10 20.345 29.401 46.529 1.00017.55ANISOU 86CALEU 10 2263 1856 2551 -582 -694 36ATOM 87C LEU 10 21.079 30.373 45.591 1.00018.84ANISOU 87C LEU 10 2506 1870 2784 -596 -830 357ATOM 88O LEU 10 21.573 30.025 44.520 1.00020.19ANISOU 88O LEU 10 2705 2263 2704 -524 -663 508ATOM 89CBLEU 10 18.844 29.559 46.327 1.00018.87ANISOU 89CBLEU 10 2302 2516 2354 -288 -715 280ATOM 90CGLEU 10 18.355 29.333 44.895 1.00018.28ANISOU 90CGLEU 10 2182 2172 2591 -668 -677 -301ATOM 91CD1 LEU 10 18.708 27.955 44.397 1.00022.45ANISOU 91CD1 LEU 10 3418 2024 3089 -308 -537 17ATOM 92CD2 LEU 10 16.852 29.603 44.869 1.00021.93ANISOU 92CD2LEU 102250 2658 3424 -504 -1139 75ATOM 93N ALA 1121.154 31.638 46.037 1.000 2.005ANISOU 93N ALA 112862 1780 2977 -595 -1279 472ATOM 94CA ALA 1121.810 32.647 45.202 1.000 24.24ANISOU 94CA ALA 113160 1670 4380 -455 -979 891ATOM 95C ALA 1123.285 32.309 44.946 1.000 21.06ANISOU 95C ALA 113128 1937 2937 -644 -1016 431ATOM 96O ALA 1123.819 32.447 43.829 1.000 26.29ANISOU 96O ALA 113569 3261 3158 -1628 -923 1137ATOM 97CB ALA 1121.752 33.989 45.953 1.000 24.29ANISOU 97CB ALA 113740 1692 3797 -461 -216 996ATOM 98N GLU 1223.953 31.844 46.005 1.000 20.65ANISOU 98N GLU 122829 1975 3044 -828 -930 674ATOM 99CA GLU 1225.354 31.463 45.862 1.000 21.19ANISOU 99CA GLU 123036 2400 2615 -506 -715 598ATOM 100 C GLU 1225.483 30.277 44.920 1.000 21.56ANISOU 100 C GLU 123894 2179 2117 -702 -206 988ATOM 101 O GLU 1226.375 30.215 44.069 1.000 21.98ANISOU 101 O GLU 123463 2917 1971 -1144 -488 618ATOM 102 CB GLU 1226.032 31.170 47.204 1.000 20.27ANISOU 102 CB GLU 122874 2192 2636 -221 -624 501ATOM 103 CG GLU 1226.156 32.451 48.032 1.000 20.54ANISOU 103 CG GLU 122889 2316 2598 -344 -516 406ATOM 104 CD GLU 1226.787 32.279 49.389 1.000 21.86ANISOU 104 CD GLU 123146 2542 2619 -1297 -612 799ATOM 105 OE1GLU 1227.068 31.149 49.803 1.000 24.98ANISOU 105 OE1GLU 123642 2681 3169 -1348 -1088 1134ATOM 106 OE2GLU 1226.819 33.305 50.092 1.000 33.52ANISOU 106 OE2GLU 125881 2966 3888 -1119 -2251 46ATOM 107 N LEU 1324.600 29.295 45.060 1.000 18.91ANISOU 107 N LEU 132567 2345 2275 -351 -390 382ATOM 108 CA LEU 1324.645 28.117 44.174 1.000 18.61ANISOU 108 CA LEU 132575 2347 2149 -209 270406ATOM 109 C LEU 1324.432 28.566 42.738 1.000 21.40ANISOU 109 C LEU 133558 2367 2206 -709 -41526ATOM 110 O LEU 1325.102 28.095 41.824 1.000 23.75ANISOU 110 O LEU 133827 3216 1981 -823 -117 190ATOM 111 CB LEU 1323.541 27.137 44.562 1.000 18.97ANISOU 111 CB LEU 132982 2243 1984 -462 -145 440ATOM 112 CG LEU 1323.773 26.344 45.860 1.000 18.57ANISOU 112 CG LEU 132313 2322 2422 -467 -362 745ATOM 113 CD1LEU 1322.526 25.480 46.070 1.000 20.74ANISOU 113 CD1LEU 132769 2266 2845 -789 -142 594ATOM 114 CD2LEU 1325.023 25.473 45.858 1.000 19.80ANISOU 114 CD2LEU 132709 2229 2585 -244 -509 -107ATOM 115 N GLN 1423.544 29.508 42.478 1.000 22.03ANISOU 115 N GLN 143596 2139 2635 -960 -903 379ATOM 116 CA GLN 1423.284 29.978 41.104 1.000 23.79ANISOU 116 CA GLN 143010 3335 2694 -992 -816 648ATOM 117 C GLN 1424.481 30.712 40.509 1.000 25.44ANISOU 117 C GLN 143360 3427 2881 -1070 -382 487ATOM 118 O GLN 1424.655 30.829 39.288 1.000 30.04ANISOU 118 O GLN 143836 4657 2922 -1208 -427 898AOM 119 CB GLN 1422.064 30.906 41.131 1.000 26.28ANISOU 119 CB GLN 143133 3630 3222 -760 -863 938ATOM 120 CG GLN 1420.772 30.111 41.355 1.000 23.26ANISOU 120 CG GLN 143106 2319 3413 -299 -577 514ATOM 121 CD GLN 1419.586 31.020 41.631 1.000 23.69ANISOU 121 CD GLN 143384 2462 3155 -317 -393 -196ATOM 122 OE1GLN 1419.734 32.104 42.160 1.000 28.34ANISOU 122 OE1GLN 144973 2619 3175 -183 -732 -408ATOM 123 NE2 GLN 14 18.398 30.513 41.349 1.000 23.60ANISOU 123 NE2 GLN 14 3058 2969 2941 -38354 245ATOM 124 N GLN 15 25.309 31.243 41.395 1.000 25.00ANISOU 124 N GLN 15 3078 3281 3140 -1159 -394 575ATOM 125 CA GLN 15 26.530 31.936 40.945 1.000 24.05ANISOU 125 CA GLN 15 2947 3560 2631 -866-98655ATOM 126 C GLN 15 27.650 30.920 40.707 1.000 26.06ANISOU 126 C GLN 15 3810 3951 2139 -345406668ATOM 127 O GLN 15 28.756 31.284 40.302 1.000 35.85ANISOU 127 O GLN 15 4294 4851 4476 102 1871 1192ATOM 128 CB GLN 15 27.018 32.918 42.009 1.000 25.90ANISOU 128 CB GLN 15 3055 3037 3748 -1092 -109 364ATOM 129 CG GLN 15 26.103 34.092 42.219 1.000 31.24ANISOU 129 CG GLN 15 4562 2577 4731 -8069621054ATOM 130 CD GLN 15 26.503 35.022 43.348 1.000 59.75ANISOU 130 CD GLN 15 9927 2475 10301-1855 -14-1904ATOM 131 OE1 GLN 15 27.634 35.031 43.840 1.000 81.81ANISOU 131 OE1 GLN 15 150593931 12094-944-6272 -1803ATOM 132 NE2 GLN 15 25.539 35.841 43.767 1.000 91.46ANISU 132 NE2 GLN 15 140704846 15833-9233672 -4850ATOM 133 N GLY 16 27.379 29.643 40.969 1.000 29.90ANISOU 133 N GLY 16 4634 3820 2907 -23922 787ATOM 134 CA GLY 16 28.410 28.649 40.699 1.000 28.76ANISOU 134 CA GLY 16 4466 3629 2833 -709461250ATOM 135 C GLY 16 29.339 28.473 41.878 1.000 27.60ANISOU 135 C GLY 16 3816 3779 2891 -6169141485ATOM 136 O GLY 16 30.398 27.867 41.725 1.000 31.47ANISOU 136 O GLY 16 3386 4758 3814 -8991243 1023ATOM 137 N LEU 17 28.960 28.898 43.083 1.000 26.01ANISOU 137 N LEU 17 3295 3636 2950 -721162743ATOM 138 CA LEU 17 29.776 28.666 44.257 1.000 23.96ANISOU 138 CA LEU 17 2700 3032 3372 -601100673ATOM 139 C LEU 17 29.462 27.338 44.932 1.000 20.31ANISOU 139 C LEU 17 2222 2763 2733 -252611261ATOM 140 O LEU 17 28.389 26.780 44.789 1.000 23.13ANISOU 140 O LEU 17 2347 3134 3308 -443263859ATOM 141 CB LEU 17 29.645 29.806 45.286 1.000 25.94ANISU 141 CB LEU 17 2886 2933 4035 -1318 -405 254ATOM 142 CG LEU 17 29.962 31.209 44.716 1.000 31.57ANISOU 142 CG LEU 17 3741 2948 5308 -5231150 722ATOM 143 CD1 LEU 17 29.550 32.358 45.615 1.000 32.04ANISOU 143 CD1 LEU 17 5221 2887 4066 -1269 278508ATOM 144 CD2 LEU 17 31.458 31.278 44.416 1.000 38.11ANISOU 144 CD2 LEU 17 3828 5491 5160 -2315 954232ATOM 145 N HIS 18 30.441 26.822 45.681 1.000 22.49ANISOU 145 N HIS 18 2600 3067 2877 -66242 449ATOM 146 CA HIS 18 30.289 25.644 46.537 1.000 21.54ANISOU 146 CA HIS 18 2378 2809 2996 -432201313ATOM 147 C HIS 18 29.908 24.376 45.790 1.000 22.76ANISOU 147 C HIS 18 2256 3245 3148 -1009 282114ATOM 148 O HIS 18 29.147 23.565 46.331 1.000 22.60ANISOU 148 O HIS 18 2008 3064 3516 -629-166 884ATOM 149 CB HIS 18 29.224 25.872 47.618 1.000 22.81ANISOU 149 CB HIS 18 2514 2879 3272 -526450421ATOM 150 CG HIS 18 29.320 27.248 48.217 1.000 21.70ANISOU 150 CG HIS 18 2797 3038 2411 -14939 503ATOM 151 ND1 HIS 18 30.438 27.773 48.807 1.000 25.01ANISOU 151 ND1 HIS 18 3714 3505 2284 -207-629 149ATOM 152 CD2 HIS 18 28.370 28.216 48.269 1.000 24.95ANISOU 152 CD2 HIS 18 3244 3278 2957 87 544275ATOM 153 CE1 HIS 18 30.197 28.982 49.223 1.000 29.26ANISOU 153 CE1 HIS 18 46033396 3118 -388 -335 27ATOM 154 NE2 HIS 18 28.937 29.271 48.9191.000 27.24ANISOU 154 NE2 HIS 18 45823137 2632 2 224365ATOM 155 NGLN 19 30.269 24.270 44.5211.000 22．74ANISOU 155 NGLN 19 27243094 2822 -511 -123 423ATOM 156 CA GLN 19 29.806 23.113 43.7301.000 23．85ANISOU 156 CA GLN 19 31292668 3263 148 63 89ATOM 157 CGLN 19 30.271 21.760 44.2211.000 22.77ANISOU 157 CGLN 19 25323026 3095 -502 -574 778ATOM 158 OGLN 19 29.480 20.801 44.2591.000 21．99ANISOU 158 OGLN 19 18692911 3574 -187 0 558ATOM 159 CB GLN 19 30.227 23.322 42.2761.000 27．66ANISOU 159 CB GLN 19 50432519 2947 29-339 458ATOM 160 CG GLN 19 29.397 24.333 41.5231.000 26.21ANISOU 160 CG GLN 19 32893163 3508 299 171437ATOM 161 CD GLN 19 27.917 24.368 41.8621.000 32.47ANISOU 161 CD GLN 19 34034411 4521 -986 535654ATOM 162 OE1 GLN 19 27.154 23.604 41.2771.000 39.69ANISOU 162 OE1 GLN 19 39964238 6845 -262 -2770 1829ATOM 163 NE2 GLN 19 27.511 25.212 42.8111.000 42.55ANISOU 163 NE2 GLN 19 38036153 6212 811944 11ATOM 164 NASP 20 31.526 21.572 44.6311.000 22.63ANISOU 164 NASP 20 20733400 3123 -414 95 708ATOM 165 CA ASP 20 31.926 20.292 45.2251.000 23.10ANISOU 165 CA ASP 20 18693674 3235 83236704ATOM 166 CASP 20 31.190 20.042 46.5461.000 20.03ANISOU 166 CASP 20 17752963 2873 -280 -143 493ATOM 167 OASP 20 30.772 18.899 46.7681.000 21.48ANISOU 167 OASP 20 14292884 3848 -311 225224ATOM 168 CB ASP 20 33.414 20.268 45.5211.000 27.66ANISOU 168 CB ASP 20 18354546 4130 -16 207881ATOM 169 CG ASP 20 34.298 20.206 44.2911.000 39.35ANISOU 169 CG ASP 20 23556893 5705 -654 1323 -1915ATOM 170 OD1 ASP 20 33.870 19.914 43.1531.000 35.78ANISOU 170 OD1 ASP 20 31525452 4992 -741 1508 -797ATOM 171 OD2 ASP 20 35.508 20.433 44.4671.000 45.22ANISOU 171 OD2 ASP 20 22018705 6277 -589 1088 -87ATOM 172 NGLU 21 31.046 21.053 47.4041.000 20.01ANISOU 172 NGLU 21 15742935 3093 -412 -241 367ATOM 173 CA GLU 21 30.323 20.811 48.6651.000 18.97ANISOU 173 CA GLU 21 14122956 2838 -481 -464 118ATOM 174 CGLU 21 28.858 20.448 48.4021.000 17.84ANISOU 174 CGLU 21 13862342 3050 -307 -395 234ATOM 175 OGLU 21 28.290 19.602 49.0541.000 18.46ANISOU 175 OGLU 21 16712286 3057 -419 -351 116ATOM 176 CB GLU 21 30.415 22.058 49.5631.000 20.10ANISOU 176 CB GLU 21 16462821 3170 -514 -499 127ATOM 177 CG GLU 21 31.893 22.322 49.9181.000 24.11ANISOU 177 CG GLU 21 16823568 3912 -766 -326 -711ATOM 178 CD GLU 21 32.574 23.380 49.0811.000 29.70ANISOU 178 CD GLU 21 13304241 5713 -752 -666 521ATOM 179 OE1 GLU 21 32.249 23.594 47.8871.000 35.14ANISOU 179 OE1 GLU 21 26234054 6677 -1336 -1741 1977ATOM 180 OE2 GLU 21 33.483 24.007 49.6781.000 39.39ANISOU 180 E2 GLU 21 36814425 6860 -2089 -1618 647ATOM 181 NPHE 22 28.231 21.048 47.3951.000 17.30ANISOU 181 NPHE 22 15402352 2680 -243 -446 -79ATOM 182 CA PHE 22 26.851 20.761 47.0711.000 17.13ANISOU 182 CA PHE 22 15342166 2807 -235 -396 374ATOM 183 CPHE 22 26.733 19.329 46.5521.000 17.41ANISOU 183 CPHE 22 16882500 2427 -502 -334 104ATOM 184 O PHE 22 25.867 18.574 46.995 1.000 15.87ANISOU 184 O PHE 22 157021182343-249 -361 131ATOM 185 CB PHE 22 26.305 21.840 46.149 1.000 18.00ANISOU 185 CB PHE 22 17472754233770 -178445ATOM 186 CG PHE 22 24.802 21.729 45.930 1.000 16.38ANISOU 186 CG PHE 22 176317482714-90 -326 223ATOM 187 CD1PHE 22 23.934 21.723 47.003 1.000 18.29ANISOU 187 CD1PHE 22 181220913045-197 -88576ATOM 188 CD2PHE 22 24.290 21.720 44.641 1.000 18.62ANISOU 188 CD2PHE 22 210620792890-143 -623 394ATOM 189 CE1PHE 22 22.569 21.727 46.771 1.000 18.90ANISOU 189 CE1PHE 22 182620863271-198 -133 302ATOM 190 CE2PHE 22 22.911 21.660 44.379 1.000 19.28ANISOU 190 CE2PHE 22 218920233114-242 -754 -144ATOM 191 CZ PHE 22 22.059 21.645 45.473 1.000 19.42ANISOU 191 CZ PHE 22 20481723360790-483 -376ATOM 192 N ARG 23 27.580 18.971 45.583 1.000 17.88ANISOU 192 N ARG 23 164724372709-168 -218 317ATOM 193 CA ARG 23 27.520 17.594 45.079 1.000 19.18ANISOU 193 CA ARG 23 172425393022-166 36 158ATOM 194 C ARG 23 27.767 16.595 46.211 1.000 19.11ANISOU 194 C ARG 23 127924613518-173 -113 455ATOM 195 O ARG 23 27.107 15.547 46.229 1.000 18.82ANISOU 195 O ARG 23 161421563381-33 181-128ATOM 196 CB ARG 23 28.605 17.351 44.030 1.000 22.81ANISOU 196 CB ARG 23 193440992633-34 -105 -354ATOM 197 CG ARG 23 28.248 17.790 42.617 1.000 24.82ANISOU 197 CG ARG 23 260140782752191 -122 -204ATOM 198 CD ARG 23 29.376 17.272 41.685 1.000 29.71ANISOU 198 CD ARG 23 250356193168-285 908704ATOM 199 NE ARG 23 30.479 18.206 41.800 1.000 30.96ANISOU 199 NE ARG 23 287750343851-43 286297ATOM 200 CZ ARG 23 30.549 19.360 41.148 1.000 29.49ANISOU 200 CZ ARG 23 261250633529-225 606177ATOM 201 NH1ARG 23 29.536 19.665 40.328 1.000 29.26ANISOU 201 NH1ARG 23 324249512923-960 331525ATOM 202 NH2ARG 23 31.629 20.092 41.345 1.000 32.61ANISOU 202 NH2ARG 23 232053474722-134 519179ATOM 203 N ARG 24 28.708 16.851 47.125 1.000 17.80ANISOU 203 N ARG 24 126221683332183 38 98ATOM 204 CA ARG 24 28.930 15.899 48.222 1.000 18.85ANISOU 204 CA ARG 24 13682509328769-162 105ATOM 205 C ARG 24 27.701 15.811 49.114 1.000 17.51ANISOU 205 C ARG 24 145620153181132 -177 243ATOM 206 O ARG 24 27.333 14.733 49.544 1.000 17.93ANISOU 206 O ARG 24 185119652997-16 -402 253ATOM 207 CB ARG 24 30.203 16.321 48.991 1.000 19.88ANISOU 207 CB ARG 24 168527003169-398 -218 44ATOM 208 CG ARG 24 31.459 16.053 48.135 1.000 29.07ANISOU 208 CG ARG 24 146746254954269 203709ATOM 209 CD ARG 24 32.700 16.206 49.016 1.000 41.84ANISOU 209 CD ARG 24 174570217130-451 -494 -922ATOM 210 NE ARG 24 33.690 17.103 48.464 1.000 57.06ANISOU 210 NE ARG 24 436293168003-3326 -669 -1141ATOM 211 CZ ARG 24 34.032 18.327 48.810 1.000 60.67ANISOU 211 CZ ARG 24 596110369 6723-4627 -1324 -1586ATOM 212 NH1ARG 24 33.430 18.980 49.799 1.000 49.70ANISOU 212 NH1ARG 24 774865654569-951 -2185 2226ATOM 213 NH2ARG 24 34.997 18.971 48.159 1.000 54.12ANISOU 213 NH2ARG 24 869684903378-3780 -2352 1607ATOM 214 N CYS 25 27.092 16.963 49.370 1.000 15.74ANISOU 214 N CYS 25 143519692574 -16 -393 -33ATOM 215 CA CYS 25 25.884 16.921 50.2231.00016.39ANISOU 215 CA CYS 25 151819542756 -95 -317 -300ATOM 216 C CYS 25 24.826 16.068 49.5471.00015.73ANISOU 216 C CYS 25 162916992648 -114 -432 66ATOM 217 O CYS 25 24.124 15.262 50.1551.00015.89ANISOU 217 O CYS 25 145318012783 -88 -469 252ATOM 218 CB CYS 25 25.367 18.362 50.4241.00015.93ANISOU 218 CB CYS 25 164417792629 -49 -261 -30ATOM 219 SG CYS 25 23.700 18.417 51.1841.00017.82ANISOU 219 SG CYS 25 174218253202 -122 -33-55ATOM 220 N LEU 26 24.623 16.308 48.2501.00015.25ANISOU 220 N LEU 26 144918432504 -54 -263 -142ATOM 221 CA LEU 26 23.560 15.590 47.5341.00015.62ANISOU 221 CA LEU 26 161617392580 -86 -453 48ATOM 222 C LEU 26 23.763 14.085 47.6211.00015.18ANISOU 222 C LEU 26 169717642306 -113 -479 6ATOM 223 O LEU 26 22.819 13.345 47.7711.00016.96ANISOU 223 O LEU 26 179717252920 -234 -664 -300ATOM 224 CB LEU 26 23.526 16.068 46.0661.00016.02ANISOU 224 CB LEU 26 181116452633 -191 -483 122ATOM 225 CG LEU 26 23.057 17.510 45.8641.00015.69ANISOU 225 CG LEU 26 176217162485 -6 -1579ATOM 226 CD1LEU 26 23.252 17.880 44.4051.00017.48ANISOU 226 CD1LEU 26 175023602532 -17 -130 465ATOM 227 CD2LEU 26 21.584 17.680 46.2901.00017.11ANISOU 227 CD2LEU 26 165521882660 -29 -75168ATOM 228 N ARG 27 25.027 13.648 47.4941.00017.26ANISOU 228 N ARG 27 187018182871 155 -326 140ATOM 229 CA ARG 27 25.295 12.205 47.3721.00018.75ANISOU 229 CA ARG 27 210818453170 270 -955 102ATOM 230 C ARG 27 25.240 11.599 48.7441.00017.95ANISOU 230 C ARG 27 166718013351 159 -897 219ATOM 231 O ARG 27 24.777 10.454 48.9131.00020.99ANISOU 231 O ARG 27 215817934026 -43 -360 168ATOM 232 CB ARG 27 26.641 12.008 46.6701.00021.35ANISOU 232 CB ARG 27 281520343264 622 -377 -129ATOM 233 N ASP 28 25.827 12.293 49.7231.00016.71ANISOU 233 N ASP 28 148720042856 178 -328 67ATOM 234 CA ASP 28 26.034 11.672 51.0261.00017.47ANISOU 234 CA ASP 28 161320952931 107 -301 127ATOM 235 C ASP 28 24.872 11.866 51.9901.00017.22ANISOU 235 C ASP 28 141422642863 223 -447 471ATOM 236 O ASP 28 24.816 11.081 52.9371.00017.62ANISOU 236 O ASP 28 193221392624 150 -565 327ATOM 237 CB ASP 28 27.306 12.237 51.6571.00022.17ANISOU 237 CB ASP 28 158138942948 -272 -467 559ATOM 238 CG ASP 28 28.590 11.906 50.9411.00024.72ANISOU 238 CG ASP 28 159633234472 236 -288 648ATOM 239 OD1ASP 28 28.572 10.905 50.1991.00027.56ANISOU 239 OD1ASP 28 231730715084 808 -284 572ATOM 240 OD2ASP 28 29.573 12.617 51.2511.00032.08ANISOU 240 OD2ASP 28 158443436261 -144 -470 416ATOM 241 N LYS 29 24.098 12.942 51.8211.00015.57ANISOU 241 N LYS 29 147518142627 5-303 178ATOM 242 CA LYS 29 23.048 13.305 52.7781.00015.13ANISOU 242 CA LYS 29 158419992165 -68 -500 -96ATOM 243 C LYS 29 21.686 13.500 52.1181.00014.56ANISOU 243 C LYS 29 149613522686 77 -452 106ATOM 244 O LYS 29 20.688 12.985 52.6351.00016.21ANISOU 244 O LYS 29 162718762657 -177 -315 -5ATOM 245 CB LYS 29 23.431 14.563 53.5741.00016.09ANISOU 245 CB LYS 29 166616722777 3-642 -25ATOM 246 CG LYS 29 24.776 14.421 54.2921.00017.68ANISOU 246 CG LYS 29 219219182606 7-1144 141ATOM 247 CD LYS 29 25.161 15.647 55.0961.00020.71ANISOU 247 CD LYS 29 267520443151 -35 -1518 41ATOM 248 CE LYS 29 26.498 15.331 55.8441.00022.24ANISOU 248 CE LYS 29 220327143535 142 -1369 -685ATOM 249 NZ LYS 29 26.955 16.594 56.4921.00032.67ANISOU 249 NZ LYS 29 319933815831 -502 -2085 -1260ATOM 250 N GLY 30 21.604 14.198 50.9931.00014.09ANISOU 250 N GLY 30 155214612340 135 -455 -100ATOM 251 CA GLY 30 20.358 14.373 50.2501.00014.09ANISOU 251 CA GLY 30 142815612365 92 -342 -97ATOM 252 C GLY 30 19.372 15.284 50.9551.00012.30ANISOU 252 C GLY 30 142311922059 -95 -275 94ATOM 253 O GLY 30 18.168 15.223 50.6961.00014.58ANISOU 253 O GLY 30 143516892415 52 -476 -121ATOM 254 N LEU 31 19.884 16.146 51.8231.00013.93ANISOU 254 N LEU 31 147214792343 -182 -248 -181ATOM 255 CA LEU 31 19.012 17.114 52.5111.00014.44ANISOU 255 CA LEU 31 153414572495 -235 -55-246ATOM 256 C LEU 31 19.894 18.286 52.9421.00015.08ANISOU 256 C LEU 31 141115352784 -177 -326 -314ATOM 257 O LEU 31 21.113 18.136 53.1401.00015.64ANISOU 257 O LEU 31 146816642812 -169 -328 -67ATOM 258 CB LEU 31 18.222 16.560 53.6941.00016.76ANISOU 258 CB LEU 31 219216642511 -367 128-213ATOM 259 CG LEU 31 18.883 16.517 55.0391.00020.16ANISOU 259 CG LEU 31 243524852739 -289 -141 445ATOM 260 CD1LEU 31 17.977 16.145 56.2021.00026.49ANISOU 260 CD1LEU 31 225350762738 -508 -341 969ATOM 261 CD2LEU 31 20.052 15.526 55.0321.00024.73ANISOU 261 CD2LEU 31 419229672237 1001 153610ATOM 262 N PHE 32 19.289 19.462 53.0521.00014.11ANISOU 262 N PHE 32 156914572335 -231 -179 -207ATOM 263 CA PHE 32 20.020 20.697 53.4171.00013.56ANISOU 263 CA PHE 32 1447 13892317 -225 -137 14ATOM 264 C PHE 32 18.976 21.777 53.6871.00013.72ANISOU 264 C PHE 32 141114392365 -218 -421 -142ATOM 265 O PHE 32 17.889 21.711 53.1181.00015.50ANISOU 265 O PHE 32 139218622634 -175 -436 -389ATOM 266 CB PHE 32 20.958 21.157 52.3081.00015.01ANISOU 266 CB PHE 32 137922012125 -305 -342 231ATOM 267 CG PHE 32 20.381 21.156 50.9201.00014.60ANISOU 267 CG PHE 32 164916622237 -193 -429 118ATOM 268 CD1PHE 32 20.326 19.986 50.1481.00014.53ANISOU 268 CD1PHE 32 132816882504 -156 -507 15ATOM 269 CD2PHE 32 19.831 22.345 50.3961.00013.66ANISOU 269 CD2PHE 32 132016782191 -179 -309 166ATOM 270 CE1PHE 32 19.742 20.033 48.8921.00014.26ANISOU 270 CE1PHE 32 150716552256 -346 -271 199ATOM 271 CE2PHE 32 19.267 22.348 49.1381.00015.49ANISOU 271 CE2PHE 32 168119322272 72 -504 -126ATOM 272 CZ PHE 32 19.177 21.184 48.3851.00015.25ANISOU 272 CZ PHE 32 197917002117 -185 -295 168ATOM 273 N TYR 33 19.376 22.785 54.4421.00014.44ANISOU 273 N TYR 33 181313022372 -237 -496 -50ATOM 274 CA TYR 33 18.616 24.023 54.5191.00014.32ANISOU 274 CA TYR 33 176414152261 -143 -295 -111ATOM 275 C TYR 33 19.039 24.929 53.3641.00013.70ANISOU 275 C TYR 33 1479 1565 2161 -79 -459 -5ATOM 276 O TYR 33 20.158 24.871 52.859 1.000 15.28ANISOU 276 O TYR 33 1370 1524 2912 -190-420 263ATOM 277 CB TYR 33 18.874 24.734 55.853 1.000 14.47ANISOU 277 CB TYR 33 1648 1717 2133 -197-309 -131ATOM 278 CG TYR 33 18.231 24.046 57.049 1.000 15.71ANISOU 278 CG TYR 33 2131 1537 2302 -339-109 -136ATOM 279 CD1 TYR 33 16.938 24.390 57.453 1.000 17.41ANISOU 279 CD1 TYR 33 2478 1967 2172 -154246-249ATOM 280 CD2 TYR 33 18.912 23.116 57.799 1.000 19.58ANISOU 280 CD2 TYR 33 2901 2070 2468 144 115192ATOM 281 CE1 TYR 33 16.354 23.758 58.542 1.000 20.18ANISOU 281 CE1 TYR 33 3138 1948 2581 26 740-102ATOM 282 CE2 TYR 33 18.368 22.475 58.900 1.000 21.50ANISOU 282 CE2 TYR 33 3571 2480 2118 340 196122ATOM 283 CZ TYR 33 17.081 22.821 59.263 1.000 22.02ANISOU 283 CZ TYR 33 4140 1772 2454 471 1035 -105ATOM 284 OH TYR 33 16.541 22.194 60.355 1.000 29.55ANISOU 284 OH TYR 33 5088 2809 3329 377 1512 728ATOM 285 N LEU 34 18.076 25.709 52.878 1.000 14.28ANISOU 285 N LEU 34 1496 1533 2396 -80 -517 -17ATOM 286 CA LEU 34 18.278 26.620 51.756 1.000 15.02ANISOU 286 CA LEU 34 1830 1452 2425 -126-580 20ATOM 287 C LEU 34 17.871 28.039 52.151 1.000 14.46ANISOU 287 C LEU 34 1703 1575 2217 -146-241 -7ATOM 288 O LEU 34 16.716 28.289 52.492 1.000 16.95ANISOU 288 O LEU 34 1663 1852 2923 -75 -186 -64ATOM 289 CB LEU 34 17.389 26.127 50.598 1.000 16.54ANISOU 289 CB LEU 34 2355 1485 2444 -212-749 25ATOM 290 CG LEU 34 17.633 26.800 49.249 1.000 15.65ANISOU 290 CG LEU 34 2010 1567 2371 -7 -633 -63ATOM 291 CD1 LEU 34 18.977 26.422 48.664 1.000 20.14ANISOU 291 CD1 LEU 34 1919 2018 3717 -225-171 260ATOM 292 CD2 LEU 34 16.490 26.535 48.291 1.000 17.29ANISOU 292 CD2 LEU 34 2152 1824 2592 -425-819 214ATOM 293 N THR 35 18.842 28.944 52.065 1.000 15.48ANISOU 293 N THR 35 1817 1532 2534 -230-200 13ATOM 294 CA THR 35 18.587 30.362 52.324 1.000 17.02ANISOU 294 CA THR 35 2149 1537 2781 -206-827 -196ATOM 295 C THR 35 18.491 31.127 51.010 1.000 17.04ANISOU 295 C THR 35 1895 1693 2887 -149-882 -44ATOM 296 O THR 35 18.765 30.572 49.938 1.000 17.01ANISOU 296 O THR 35 1880 1692 2893 -262-458 144ATOM 297 CB THR 35 19.772 30.917 53.180 1.000 17.79ANISOU 297 CB THR 35 2018 1942 2800 -87 -854 -200ATOM 298 OG1 THR 35 20.986 30.673 52.474 1.000 21.10ANISOU 298 OG1 THR 35 2110 2035 3873 -253-364 -402ATOM 299 CG2 THR 35 19.847 30.331 54.567 1.000 20.44ANISOU 299 CG2 THR 35 2600 2194 2971 228 -1113 59ATOM 300 N ASP 36 18.186 32.407 51.059 1.000 18.62ANISOU 300 N ASP 36 2287 1747 3040 -187-316 149ATOM 301 CA ASP 36 18.240 33.300 49.884 1.000 20.75ANISOU 301 CA ASP 36 2678 1722 3483 -632-508 374ATOM 302 C ASP 36 17.474 32.711 48.703 1.000 20.05ANISOU 302 C ASP 36 2104 1929 3586 198 -928 489ATOM 303 O ASP 36 17.929 32.685 47.540 1.000 21.06ANISOU 303 O ASP 36 2593 1749 3662 -496-756 131ATOM 304 CB ASP 36 19.703 33.561 49.500 1.000 22.21ANISOU 304 CB ASP 36 2666 2366 3406 -876-755 807ATOM 305 CG ASP 36 20.588 34.192 50.551 1.000 23.05ANISOU 305 CG ASP 36 2537 1818 4402 -175-833 -208ATOM 306 OD1 ASP 36 20.061 34.886 51.457 1.000 26.16ANISOU 306 OD1 ASP 36 2981 2100 4860 378 -777 -381ATOM 307 OD2 ASP 36 21.824 33.982 50.528 1.000 24.87ANISOU 307 OD2 ASP 36 2532 1994 4924 -49 -950 -628ATOM 308 N CYS 37 16.282 32.196 48.971 1.000 20.25ANISOU 308 N CYS 37 2135 1711 3849 118 -638 -263ATOM 309 CA CYS 37 15.463 31.587 47.902 1.000 20.28ANISOU 309 CA CYS 37 2390 1478 3839 136 -799 -138ATOM 310 C CYS 37 14.078 32.183 47.818 1.000 19.90ANISOU 310 C CYS 37 2374 1724 3463 214 -711 -74ATOM 311 O CYS 37 13.176 31.629 47.156 1.000 22.75ANISOU 311 O CYS 37 2569 1984 4091 -12 -1108 15ATOM 312 CB CYS 37 15.359 30.061 48.083 1.000 22.21ANISOU 312 CB CYS 37 2739 1454 4247 194 -477 -115ATOM 313 SG CYS 37 14.500 29.595 49.596 1.000 22.84ANISOU 313 SG CYS 37 2854 1884 3942 -203-922 141ATOM 314 N GLY 38 13.855 33.390 48.314 1.000 20.85ANISOU 314 N GLY 38 2353 1638 3933 217 -375 -42ATOM 315 CA GLY 38 12.570 34.044 48.194 1.000 23.42ANISOU 315 CA GLY 38 2233 1874 4790 255 -292 165ATOM 316 C GLY 38 11.534 33.619 49.217 1.000 23.29ANISOU 316 C GLY 38 2577 2045 4228 113 -136 -601ATOM 317 O GLY 38 10.400 34.091 49.129 1.000 25.58ANISOU 317 O GLY 38 2529 3424 3765 214 -96-264ATOM 318 N LEU 39 11.894 32.836 50.237 1.000 24.55ANISOU 318 N LEU 39 2310 2980 4037 119 -46-364ATOM 319 CA LEU 39 10.938 32.331 51.195 1.000 24.44ANISOU 319 CA LEU 39 2637 2964 3684 -105175-946ATOM 320 C LEU 39 11.107 32.885 52.593 1.000 35.41ANISOU 320 C LEU 39 5341 4215 3898 -796165-1435ATOM 321 O LEU 39 11.784 32.313 53.441 1.000 43.41ANISOU 321 O LEU 39 7338 4986 4171 -2639 -1333 -303ATOM 322 CB LEU 39 10.850 30.810 51.206 1.000 26.48ANISOU 322 CB LEU 39 4244 2940 2879 49 -70-261ATOM 323 CG LEU 39 10.404 30.097 49.921 1.000 30.21ANISOU 323 CG LEU 39 4834 2452 4195 258 -1618 -474ATOM 324 CD1 LEU 39 10.683 28.595 49.972 1.000 24.78ANISOU 324 CD1 LEU 39 3351 2597 3468 424 -707 -118ATOM 325 CD2 LEU 39 8.94030.407 49.640 1.000 27.50ANISOU 325 CD2 LEU 39 4828 2118 3503 860 -860 -323ATOM 326 N THR 40 10.365 33.957 52.882 1.000 45.58ANISOU 326 N THR 40 7392 4849 5077 -5202852 -1993ATOM 327 CA THR 40 10.610 34.661 54.136 1.000 32.50ANISOU 327 CA THR 40 4224 3732 4393 999 961-558ATOM 328 C THR 40 9.70034.177 55.248 1.000 29.68ANISOU 328 C THR 40 3175 4204 3898 -116294-1630ATOM 329 O THR 40 8.65333.556 55.031 1.000 39.75ANISOU 329 O THR 40 3930 5847 5326 -1079 -301 -1653ATOM 330 CB THR 40 10.641 36.183 53.997 1.000 56.31ANISOU 330 CB THR 40 105863758 7052 -1417 1006 -992ATOM 331 OG1 THR 40 11.545 36.606 52.946 1.000 68.39ANISOU 331 OG1 THR 40 7379 3900 14707-1978 3617 -246ATOM 332 CG2 THR 40 11.214 36.837 55.256 1.000 70.22ANISOU 332 CG2 THR 40 8265 5228 131881389-4422 -3241ATOM 333 N ASP 41 10.191 34.302 56.486 1.000 33.20ANISOU 333 N ASP 41 3580 5223 3810 -203307-1779ATOM 334 CA ASP 41 9.32933.943 57.613 1.000 27.51ANISOU 334 CA ASP 41 2705 3858 3891 91 -253 -1061ATOM 335 C ASP 41 8.10734.861 57.660 1.000 33.43ANISOU 335 C ASP 41 3131 3064 6508 32 547-1307ATOM 336 O ASP 41 7.03434.469 58.101 1.000 30.76ANISOU 336 O ASP 41 2690 3223 5774 141 -149 -969ATOM 337 CB ASP 41 10.113 34.135 58.915 1.000 33.51ANISOU 337 CB ASP 41 4853 4026 3852 -1222 -698 -938ATOM 338 CG ASP 41 9.45333.351 60.039 1.000 33.37ANISOU 338 CG ASP 41 3324 5291 4065 -739-501 -571ATOM 339 OD1 ASP 41 9.15232.164 59.780 1.000 34.95ANISOU 339 OD1 ASP 41 4040 4681 4557 -380824-92ATOM 340 OD2 ASP 41 9.39533.904 61.161 1.000 86.76ANISOU 340 OD2 ASP 41 18972104273567 -10425 588 -1858ATOM 341 N THR 42 8.27236.089 57.205 1.000 32.71ANISOU 341 N THR 42 3217 3695 5516 9 -58-586ATOM 342 CA THR 42 7.19837.074 57.221 1.000 38.48ANISOU 342 CA THR 42 4747 4161 5711 1067-861 -630ATOM 343 C THR 42 6.00536.640 56.375 1.000 35.83ANISOU 343 C THR 42 3333 4044 6237 1136157-1162ATOM 344 O THR 42 4.87736.606 56.900 1.000 38.90ANISOU 344 O THR 42 4048 3603 7128 11861059 1224ATOM 345 CB THR 42 7.75138.449 56.815 1.000 37.05ANISOU 345 CB THR 42 4526 3763 5788 1021-677 -1532ATOM 346 OG1 THR 42 8.83138.301 55.889 1.000 98.08ANISOU 346 OG1 THR 42 16381137577127 -3208 7500 -2318ATOM 347 CG2 THR 42 8.35839.113 58.047 1.000 36.08ANISOU 347 CG2 THR 42 6097 3613 3997 886 -1119 269ATOM 348 N GLU 43 6.25936.184 55.173 1.000 34.64ANISOU 348 N GLU 43 4208 3312 5642 656 -275 -698ATOM 349 CA GLU 43 5.39135.557 54.192 1.000 32.98ANISOU 349 CA GLU 43 3527 2886 6120 1199-883 -152ATOM 350 C GLU 43 4.70134.300 54.713 1.000 41.67ANISOU 350 C GLU 43 3454 4151 8229 225 -1743 953ATOM 351 O GLU 43 3.48434.124 54.605 1.000 38.53ANISOU 351 O GLU 43 3375 4041 7222 589 -1417 -578ATOM 352 CB GLU 43 6.27835.074 53.026 1.000 44.72ANISOU 352 CB GLU 43 5991 4098 6901 28 137-2137ATOM 353 CG GLU 43 6.65836.125 52.003 1.000 53.42ANISOU 353 CG GLU 43 5931 6417 7949 -9931540 -1338ATOM 354 CD GLU 43 7.83836.976 52.429 1.000 50.41ANISOU 354 CD GLU 43 4087 7601 7467 -4392486 -1725ATOM 355 OE1 GLU 43 8.02437.112 53.661 1.000 59.44ANISOU 355 OE1 GLU 43 7237 7592 7757 -1284 1632 -2146ATOM 356 OE2 GLU 43 8.55537.476 51.531 1.000 71.33ANISOU 356 OE2 GLU 43 115506344 9207 -4131 6267 -4645ATOM 357 N LEU 44 5.51133.373 55.224 1.000 27.80ANISOU 357 N LEU 44 2837 2924 4802 -55 -626 -227ATOM 358 CA LEU 44 4.92632.222 55.902 1.000 27.88ANISOU 358 CA LEU 44 2207 3379 5009 241 813-382ATOM 359 C LEU 44 3.88632.670 56.934 1.000 34.30ANISOU 359 C LEU 44 1930 4771 6333 -537776-2629ATOM 360 O LEU 44 2.78132.159 56.924 1.000 33.35ANISOU 360 O LEU 44 2046 5235 5390 -840705-2397ATOM 361 CB LEU 44 5.99931.394 56.587 1.000 24.59ANISOU 361 CB LEU 44 2781 3494 3070 81 940-74ATOM 362 CG LEU 44 5.59230.147 57.343 1.000 31.76ANISOU 362 CG LEU 44 2414 5135 4517 -8457921217ATOM 363 CD1 LEU 44 4.56329.328 56.575 1.000 47.71ANISOU 363 CD1 LEU 44 5860 7081 5188 -3576 3333 -2541ATOM 364 CD2 LEU 44 6.79329.259 57.653 1.000 51.56ANISOU 364 CD2 LEU 44 6294 3688 9608 19562240 1382ATOM 365 N LYS 45 4.21233.712 57.694 1.000 41.91ANISOU 365 N LYS 45 2865 6802 6256 -1455 381-3537ATOM 366 CA LYS 45 3.36934.195 58.773 1.000 44.31ANISOU 366 CA LYS 45 4768 5427 6639 74 837-2985ATOM 367 C LYS 45 1.981 34.582 58.2781.00038.58ANISOU 367 C LYS 45 4535 34456681 -245 1221 -2820ATOM 368 O LYS 45 0.984 34.238 58.9021.00039.93ANISOU 368 O LYS 45 4857 35946720 262 1634 -2337ATOM 369 CB LYS 45 4.038 35.400 59.4471.00050.20ANISOU 369 CB LYS 45 4944 55618569 1081 -447 -3980ATOM 370 CG LYS 45 3.082 36.546 59.7061.00053.07ANISOU 370 CG LYS 45 3548 632110296 1148 -2094 -4809ATOM 371 CD LYS 45 3.714 37.922 59.6221.00058.29ANISOU 371 CD LYS 45 4723 569411730 1422 -3745 -5024ATOM 372 CE LYS 45 3.199 38.793 60.7611.00065.33ANISOU 372 CE LYS 45 6294 689811629 1072 -3430 -5603ATOM 373 NZ LYS 45 1.713 38.779 60.8521.00073.75ANISOU 373 NZ LYS 45 6392 921612412 -718 -1071 -7436ATOM 374 N SER 46 1.973 35.341 57.1931.00036.94ANISOU 374 N SER 46 4074 34786484 -956 1068 -2939ATOM 375 CA SER 46 0.743 35.856 56.6071.00037.61ANISOU 375 CA SER 46 3983 34176892 -1335988-2335ATOM 376 C SER 46 -0.13734.702 56.1371.00034.45ANISOU 376 C SER 46 3430 30576602 -11041656 -2394ATOM 377 O SER 46 -1.33734.625 56.4491.00029.50ANISOU 377 O SER 46 3195 27895224 -587 1093 -1206ATOM 378 CB SER 46 1.160 36.726 55.4191.00040.36ANISOU 378 CB SER 46 4102 38097425 -2099617-1930ATOM 379 OG SER 46 0.018 37.017 54.6301.00043.38ANISOU 379 OG SER 46 5005 34318048 -126153 -1863ATOM 380 N ALA 47 0.493 33.808 55.3611.00029.82ANISOU 380 N ALA 47 3246 21735910 -18 809-1228ATOM 381 CA ALA 47 -0.20832.623 54.8791.00025.84ANISOU 381 CA ALA 47 3566 21064148 7630-891ATOM 382 C ALA 47 -0.72231.792 56.0581.00025.02ANISOU 382 C ALA 47 2591 23444572 481 280-280ATOM 383 O ALA 47 -1.88831.381 56.0631.00023.19ANISOU 383 O ALA 47 2850 23663597 129 318-1119ATOM 384 CB ALA 47 0.615 31.791 53.9121.00026.76ANISOU 384 CB ALA 47 2892 27644511 270 351-1134ATOM 385 N LYS 48 0.132 31.529 57.0411.00024.64ANISOU 385 N LYS 48 3107 20764178 130 -57-1085ATOM 386 CA LYS 48 -0.18630.712 58.2021.00025.83ANISOU 386 CA LYS 48 3545 29793291 -16 30 -1416ATOM 387 C LYS 48 -1.33731.339 59.0031.00028.58ANISOU 387 C LYS 48 3373 33444144 -354 129-2041ATOM 388 O LYS 48 -2.31030.694 59.3961.00027.04ANISOU 388 O LYS 48 3849 27933633 312 419-634ATOM 389 CB LYS 48 1.035 30.654 59.1491.00028.95ANISOU 389 CB LYS 48 3507 32944200 -274 -257 -738ATOM 390 CG LYS 48 0.775 29.694 60.3131.00032.96ANISOU 390 CG LYS 48 4412 32144897 113 -543 -156ATOM 391 CD LYS 48 1.418 30.222 61.5701.00039.92ANISOU 391 CD LYS 48 5828 46164724 705 -1278 -39ATOM 392 CE LYS 48 1.217 29.320 62.7691.00033.67ANISOU 392 CE LYS 48 3973 40204799 1402 -205 -356ATOM 393 NZ LYS 48 0.731 30.100 63.9461.00038.33ANISOU 393 NZ LYS 48 4516 52304816 916 -1039 -1555ATOM 394 N ASP 49 -1.25332.656 59.2551.00023.78ANISOU 394 N ASP 49 2796 51363104 79 -459 -1588ATOM 395 CA ASP 49 -2.29833.326 60.0061.00024.05ANISOU 395 CA ASP 49 2826 29133398 -291 366-1043ATOM 396 C ASP 49 -3.67933.181 59.3661.00024.45ANISOU 396 C ASP 49 2721 32703300 -220 555-1454ATOM 397 O ASP 49 -4.63732.951 60.0821.00027.10ANISOU 397 O ASP 49 2863 3177 4257 -3681004 -1544ATOM 398 CB ASP 49 -2.034 34.824 60.167 1.000 30.34ANISOU 398 CB ASP 49 3695 3210 4623 -559713-2178ATOM 399 CG ASP 49 -0.924 35.181 61.128 1.000 37.18ANISOU 399 CG ASP 49 5259 4057 4810 -1109 -211 -2007ATOM 400 OD1 ASP 49 -0.556 34.266 61.904 1.000 33.36ANISOU 400 OD1 ASP 49 3717 4549 4408 -737888-1727ATOM 401 OD2 ASP 49 -0.525 36.375 61.087 1.000 48.45ANISOU 401 OD2 ASP 49 7960 3575 6875 -927-2887 -2409ATOM 402 N LEU 50 -3.788 33.402 58.059 1.000 24.46ANISOU 402 N LEU 50 3114 2668 3513 374 200-1298ATOM 403 CA LEU 50 -5.123 33.344 57.471 1.000 22.92ANISOU 403 CA LEU 50 2949 2145 3614 161 397-562ATOM 404 C LEU 50 -5.679 31.937 57.328 1.000 21.79ANISOU 404 C LEU 50 3345 2197 2737 33 417-556ATOM 405 O LEU 50 -6.878 31.741 57.475 1.000 24.96ANISOU 405 O LEU 50 3463 2502 3517 -276766-1181ATOM 406 CB LEU 50 -5.254 34.137 56.194 1.000 22.13ANISOU 406 CB LEU 50 3127 2016 3266 -103524-757ATOM 407 CG LEU 50 -6.661 34.578 55.807 1.000 28.87ANISOU 407 CG LEU 50 3549 3538 3881 961 825208ATOM 408 CD1 LEU 50 -7.389 35.082 57.049 1.000 52.72ANISOU 408 CD1 LEU 50 4567 8556 6907 940 2929 -1936ATOM 409 CD2 LEU 50 -6.644 35.642 54.723 1.000 41.07ANISOU 409 CD2 LEU 50 6971 3395 5240 -1005 -2258 857ATOM 410 N VAL 51 -4.801 30.956 57.138 1.000 21.78ANISOU 410 N VAL 51 3345 2052 2877 -160216-860ATOM 411 CA VAL 51 -5.293 29.580 57.118 1.000 19.40ANISOU 411 CA VAL 51 2631 2056 2683 -12 173-303ATOM 412 C VAL 51 -5.631 29.135 58.533 1.000 25.25ANISOU 412 C VAL 51 4453 2656 2485 -753587-955ATOM 413 O VAL 51 -6.652 28.454 58.725 1.000 25.07ANISOU 413 O VAL 51 4555 2176 2795 -4841185 -827ATOM 414 CB VAL 51 -4.377 28.589 56.396 1.000 18.78ANISOU 414 CB VAL 51 2729 1786 2620 -72 171-313ATOM 415 CG1 VAL 51 -3.152 28.238 57.231 1.000 20.42ANISOU 415 CG1 VAL 51 3002 1841 2918 295 -13-480ATOM 416 CG2 VAL 51 -5.147 27.306 56.021 1.000 24.10ANISOU 416 CG2 VAL 51 3112 2337 3708 -511355-846ATOM 417 N ILE 52 -4.836 29.500 59.534 1.000 25.23ANISOU 417 N ILE 52 4514 2471 2603 388 76 -874ATOM 418 CA ILE 52 -5.205 29.114 60.921 1.000 24.38ANISOU 418 CA ILE 52 3488 3010 2765 248 19 -509ATOM 419 C ILE 52 -6.498 29.771 61.355 1.000 24.20ANISOU 419 C ILE 52 3026 2482 3687 -354114-648ATOM 420 O ILE 52 -7.328 29.182 62.071 1.000 27.73ANISOU 420 O ILE 52 3735 2812 3989 -198614-334ATOM 421 CB ILE 52 -4.016 29.427 61.829 1.000 27.59ANISOU 421 CB ILE 52 3321 4347 2815 590 0 -785ATOM 422 CG1 ILE 52 -2.853 28.439 61.510 1.000 31.45ANISOU 422 CG1 ILE 52 3278 5248 3425 741 363-1288ATOM 423 CG2 ILE 52 -4.293 29.312 63.317 1.000 33.62ANISOU 423 CG2 ILE 52 3827 6199 2750 881 150-1454ATOM 424 CD1 ILE 52 -1.930 28.351 62.710 1.000 36.22ANISOU 424 CD1 ILE 52 3956 5082 4722 979 -601 -234ATOM 425 N ASP 53 -6.771 30.992 60.913 1.000 24.56ANISOU 425 N ASP 53 3479 2878 2974 165 609-426ATOM 426 CA ASP 53 -8.051 31.646 61.278 1.000 23.50ANISOU 426 CA ASP 53 3242 2942 2745 -5 355 -67 7ATOM 427 C ASP 53 -9.201 30.929 60.594 1.000 26.34ANISOU 427 C ASP 53 3462 2986 3561 -435612-1064ATOM 428 O ASP 53 -10.342 30.836 61.051 1.000 29.73ANISOU 428 O ASP 53 3468 3085 4743 -436937-1142ATOM 429 CB ASP 53 -7.96433.084 60.772 1.000 33.83ANISOU 429 CB ASP 53 3800 2322 6730 -92 1806 -933ATOM 430 CG ASP 53 -9.30833.758 60.583 1.000 32.05ANISOU 430 CG ASP 53 4652 2412 5113 172 -302 -1138ATOM 431 OD1 ASP 53 -9.65334.524 61.486 1.000 43.68ANISOU 431 OD1 ASP 53 3661 4686 8248 150 1379 -3120ATOM 432 OD2 ASP 53 -9.95033.556 59.532 1.000 51.30ANISOU 432 OD2 ASP 53 8386 6074 5033 -2062 -1738 922ATOM 433 N PHE 54 -8.93330.376 59.413 1.000 25.39ANISOU 433 N PHE 54 3372 2640 3637 72 71 -1176ATOM 434 CA PHE 54 -9.91729.557 58.704 1.000 24.10ANISOU 434 CA PHE 54 3015 3264 2876 -366263-539ATOM 435 C PHE 54 -10.180 28.259 59.456 1.000 24.00ANISOU 435 C PHE 54 3264 3174 2680 -365459-688ATOM 436 O PHE 54 -11.333 27.893 59.686 1.000 28.19ANISOU 436 O PHE 54 3551 3246 3914 -5491305 -1130ATOM 437 CB PHE 54 -9.46529.273 57.263 1.000 23.62ANISOU 437 CB PHE 54 3241 2955 2779 -249218-434ATOM 438 CG PHE 54 -10.522 28.499 56.461 1.000 27.62ANISOU 438 CG PHE 54 4712 2945 2838 -694-636 14ATOM 439 CD1 PHE 54 -11.729 29.078 56.087 1.000 31.38ANISOU 439 CD1 PHE 54 3613 4658 3654 -951-262 -621ATOM 440 CD2 PHE 54 -10.283 27.210 56.033 1.000 30.92ANISOU 440 CD2 PHE 54 5782 3589 2377 -831293-844ATOM 441 CE1 PHE 54 -12.653 28.406 55.307 1.000 44.29ANISOU 441 CE1 PHE 54 5504 5404 5919 -3066 -2057 1178ATOM 442 CE2 PHE 54 -11.228 26.503 55.306 1.000 38.69ANISOU 442 CE2 PHE 54 7997 4412 2289 -2803 155-387ATOM 443 CZ PHE 54 -12.424 27.092 54.927 1.000 42.33ANISOU 443 CZ PHE 54 5992 6305 3787 -4256 54 -446ATOM 444 N PHE 55 -9.12627.558 59.870 1.000 25.87ANISOU 444 N PHE 55 3787 2768 3276 -85 431-839ATOM 445 CA PHE 55 -9.19526.310 60.625 1.000 25.69ANISOU 445 CA PHE 55 3567 3042 3151 68 763-711ATOM 446 C PHE 55 -9.92926.484 61.944 1.000 27.69ANISOU 446 C PHE 55 3357 3961 3205 181 703-719ATOM 447 O PHE 55 -10.745 25.670 62.373 1.000 30.08ANISOU 447 O PHE 55 4046 4165 3217 142 878-127ATOM 448 CB PHE 55 -7.75925.873 60.932 1.000 25.48ANISOU 448 CB PHE 55 3556 3159 2964 117 835-638ATOM 449 CG PHE 55 -7.01925.242 59.762 1.000 26.31ANISOU 449 CG PHE 55 3437 3039 3522 -4681068 -1156ATOM 450 CD1 PHE 55 -7.61124.820 58.590 1.000 27.09ANISOU 450 CD1 PHE 55 3553 3895 2845 -1018 1404 -658ATOM 451 CD2 PHE 55 -5.65125.031 59.935 1.000 31.68ANISOU 451 CD2 PHE 55 3244 4185 4609 -7261123 -2221ATOM 452 CE1 PHE 55 -6.87824.150 57.621 1.000 23.89ANISOU 452 CE1 PHE 55 3472 2525 3079 -58 551-547ATOM 453 CE2 PHE 55 -4.90424.433 58.950 1.000 31.74ANISOU 453 CE2 PHE 55 3487 4387 4186 226 337-2304ATOM 454 CZ PHE 55 -5.51424.004 57.770 1.000 24.23ANISOU 454 CZ PHE 55 3706 2187 3312 414 -22-416ATOM 455 N GLU 56 -9.63327.581 62.629 1.000 30.39ANISOU 455 N GLU 56 3961 5033 2553 -308520-1110ATOM 456 CA GLU 56 -10.222 27.875 63.925 1.000 30.18ANISOU 456 CA GLU 56 4160 4504 2805 -7341221 -637ATOM 457 C GLU 56 -11.650 28.401 63.820 1.000 33.50ANISOU 457 C GLU 56 4324 4124 4280 -5351489 -892ATOM 458 O GLU 56 -12.470 28.149 64.708 1.000 44.44ANISOU 458OGLU 563864 88724150 93 1013 1011ATOM 459CB GLU 56-9.40328.978 64.6151.000 35.85ANISOU 459CB GLU 565037 51093475 -221574-1821ATOM 460CG GLU 56-8.19228.508 65.4011.000 38.63ANISOU 460CG GLU 564804 71522721 -337763-1692ATOM 461CD GLU 56-7.39529.699 65.9161.000 45.55ANISOU 461CD GLU 565576 71834546 -24 -295 -2330ATOM 462OE1 GLU 56-7.93530.828 65.8881.000 55.54ANISOU 462OE1 GLU 567344 72476512 586 2570 -3059ATOM 463OE2 GLU 56-6.24629.492 66.3501.000 50.41ANISOU 463OE2 GLU 564050 10497 4606 -1066 1163 -2063ATOM 464NHIS 57-11.890 29.289 62.8661.000 32.20ANISOU 464NHIS 573273 47004261 -5491540 -670ATOM 465CA HIS 57-13.101 30.078 62.9091.000 33.38ANISOU 465CA HIS 573795 48854002 -1101553 -1239ATOM 466CHIS 57-13.981 29.873 61.6971.000 32.85ANISOU 466CHIS 573380 47364367 278 1506 -1797ATOM 467OHIS 57-15.012 30.533 61.5711.000 37.09ANISOU 467OHIS 573362 47335998 276 1087 -2205ATOM 468CB HIS 57-12.802 31.573 62.9761.000 37.39ANISOU 468CB HIS 574327 49594922 -1931402 -1970ATOM 469CG HIS 57-11.981 31.949 64.1621.000 36.99ANISOU 469CG HIS 574111 50464896 680 1344 -2319ATOM 470ND1 HIS 57-12.465 31.917 65.4531.000 38.84ANISOU 470ND1 HIS 575090 48444823 -1711362 -1598ATOM 471CD2 HIS 57-10.707 32.387 64.2321.000 37.91ANISOU 471CD2 HIS 575259 41974947 -8911544 -2828ATOM 472CE1 HIS 57-11.510 32.305 66.2751.000 40.37ANISOU 472CE1 HIS 575481 51914668 -2431087 -1361ATOM 473NE2 HIS 57-10.441 32.592 65.5521.000 35.63ANISOU 473NE2 HIS 574420 43764743 980 799-1492ATOM 474NGLY 58-13.464 29.068 60.7861.000 32.06ANISOU 474NGLY 584402 31864594 5 1572 -1525ATOM 475CA GLY 58-14.290 28.731 59.6271.000 35.74ANISOU 475CA GLY 584508 44024669 -1129 1877 -1893ATOM 476CGLY 58-15.449 27.859 60.0991.000 31.52ANISOU 476CGLY 583317 36884969 308 1657 -593ATOM 477OGLY 58-15.245 26.952 60.9221.000 32.66ANISOU 477OGLY 584561 41763674 -204624-1012ATOM 478NSER 59-16.632 28.152 59.5741.000 31.03ANISOU 478NSER 593786 36234379 519 1142 -1442ATOM 479CA SER 59-17.823 27.359 59.8591.000 32.03ANISOU 479CA SER 593305 39254939 757 850-1188ATOM 480CSER 59-17.763 26.034 59.1171.000 37.27ANISOU 480CSER 593654 40016507 0 2065 -1682ATOM 481OSER 59-16.987 25.858 58.1811.000 31.23ANISOU 481OSER 593027 36555184 613 1003 -1174ATOM 482CB SER 59-19.077 28.136 59.4441.000 39.80ANISOU 482CB SER 593930 59255266 1707-545 -2846ATOM 483OG SER 59-19.252 28.159 58.0291.000 35.38ANISOU 483OG SER 593505 48005137 355 119-1624ATOM 484NGLU 60-18.589 25.065 59.5071.000 46.32ANISOU 484NGLU 605438 60836078 -2395 2115 -2700ATOM 485CA GLU 60-18.573 23.801 58.7541.000 34.21ANISOU 485CA GLU 603381 47984818 -960716-1238ATOM 486CGLU 60-19.033 24.055 57.3301.000 34.22ANISOU 486CGLU 604659 37114632 455 1378 -847ATOM 487OGLU 60-18.616 23.437 56.3611.000 29.91ANISOU 487OGLU 603708 30404615 -6792037 -604ATOM 488CB GLU 60-19.390 22.742 59.4881.000 38.26ANISOU 488CB GLU 605012 55673958 -1599 748-1000ATOM 489 CG GLU 60 -18.625 22.182 60.6781.00042.01ANISOU 489 CG GLU 60 5470 54395055 503 950-782ATOM 490 CD GLU 60 -17.307 21.528 60.3121.00045.34ANISOU 490 CD GLU 60 4036 74965695 -885 1094 -2276ATOM 491 OE1 GLU 60 -17.219 20.867 59.2641.00049.69ANISOU 491 OE1 GLU 60 5383 66896809 -864 1730 -2838ATOM 492 OE2 GLU 60 -16.323 21.659 61.0841.00043.62ANISOU 492 OE2 GLU 60 4677 49746924 -1984109-12ATOM 493 NALA 61 -19.928 25.028 57.1671.00034.26ANISOU 493 NALA 61 3091 39126014 -81 1209 -1122ATOM 494 CA ALA 61 -20.408 25.324 55.8231.00033.07ANISOU 494 CA ALA 61 1647 44096508 -228 657-1105ATOM 495 CALA 61 -19.314 25.876 54.9381.00030.69ANISOU 495 CALA 61 2053 37425866 -59 640-1066ATOM 496 OALA 61 -19.138 25.482 53.7901.00031.15ANISOU 496 OALA 61 2754 28936189 31 793-128 5ATOM 497 CB ALA 61 -21.543 26.336 55.9321.00034.43ANISOU 497 CB ALA 61 2783 44035897 288 1210 -1650ATOM 498 NGLU 62 -18.568 26.824 55.4981.00028.80ANISOU 498 NGLU 62 2168 34045371 -9 915-964ATOM 499 CA GLU 62 -17.478 27.395 54.7041.00026.78ANISOU 499 CA GLU 62 2339 23745461 423 871-413ATOM 500 CGLU 62 -16.432 26.330 54.3891.00022.61ANISOU 500 CGLU 62 2569 16214402 84 1049 -376ATOM 501 OGLU 62 -15.851 26.316 53.2891.00024.41ANISOU 501 OGLU 62 2399 26694209 -132 801-548ATOM 502 CB GLU 62 -16.861 28.591 55.4291.00032.86ANISOU 502 CB GLU 62 3129 21177239 251 2039 -1358ATOM 503 CG GLU 62 -17.739 29.834 55.5541.00034.69ANISOU 503 CG GLU 62 2824 28597499 916 -95-1430ATOM 504 CD GLU 62 -17.274 30.810 56.6161.00038.93ANISOU 504 CD GLU 62 4998 27807014 1622 224-1820ATOM 505 OE1 GLU 62 -16.861 30.391 57.7171.00040.92ANISOU 505 OE1 GLU 62 4844 36367068 1268 34 -1673ATOM 506 OE2 GLU 62 -17.324 32.041 56.3851.00045.13ANISOU 506 OE2 GLU 62 7600 28896658 -525 1698 -1099ATOM 507 NLYS 63 -16.193 25.431 55.3451.00025.20ANISOU 507 NLYS 63 2470 23804723 312 1050 8ATOM 508 CA LYS 63 -15.214 24.369 55.2071.00021.62ANISOU 508 CA LYS 63 2608 28942712 688 349-446ATOM 509 CLYS 63 -15.708 23.397 54.1471.00022.42ANISOU 509 CLYS 63 2930 30382549 84 433-217ATOM 510 OLYS 63 -14.913 23.038 53.2891.00024.17ANISOU 510 OLYS 63 3340 23543491 239 782-790ATOM 511 CB LYS 63 -14. 940 23. 650 56. 534 1.00024.50ANISOU 511 CB LYS 63 3411 30572842 42 -105 -299ATOM 512 CG LYS 63 -13.963 24.465 57.3811.00027.58ANISOU 512 CG LYS 63 4640 27923045 -302 -465 -306ATOM 513 CD LYS 63 -13.866 23.937 58.8111.00026.09ANISOU 513 CD LYS 63 3132 35703211 305 -575 -12ATOM 514 CE LYS 63 -12.761 24.695 59.5601.00028.96ANISOU 514 CE LYS 63 4342 35793083 -317 -286 -792ATOM 515 NZ LYS 63 -12.927 24.614 61.0301.00035.00ANISOU 515 NZ LYS 63 4884 53563057 64 -298 -817ATOM 516 NARG 64 -17.007 23.112 54.1431.00029.82ANISOU 516 NARG 64 3238 26765418 -533 1111 -1259ATOM 517 CA ARG 64 -17.521 22.169 53.1181.00025.56ANISOU 517 CA ARG 64 2396 24744841 -170 1252 -962ATOM 518 CARG 64 -17.417 22.735 51.7081.00028.45ANISOU 518 CARG 64 3022 26815106 153 1369 -562ATOM 519 OARG 64 -17.149 21.981 50.7591.00022.57ANISOU 519 OARG 64 1672 24664436 -71148-395ATOM 520 CB ARG 64 -18.937 21.809 53.5371.000 32.48ANISOU 520 CB ARG 64 2669 41445526 -809 1483 -1029ATOM 521 CG ARG 64 -19.094 20.442 54.1891.000 45.55ANISOU 521 CG ARG 64 4444 47498116 -2443 1343 -153ATOM 522 CD ARG 64 -20.557 19.985 54.0801.000 59.48ANISOU 522 CD ARG 64 5723 676010116 -3977 -2863 2461ATOM 523 NE ARG 64 -20.759 19.485 52.7141.000 77.63ANISOU 523 NE ARG 64 10254 93039938 -4031 -4193 2666ATOM 524 CZ ARG 64 -21.166 20.236 51.6961.000 60.23ANISOU 524 CZ ARG 64 5289 695210644 -1128 -4334 501ATOM 525 NH1 ARG 64 -21.424 21.528 51.8921.000 91.64ANISOU 525 NH1 ARG 64 18286 507211461 -5082 -3134 -75ATOM 526 NH2 ARG 64 -21.286 19.711 50.4891.000 43.67ANISOU 526 NH2 ARG 64 3318 40959178 -183 -1521 2085ATOM 527 NALA 65 -17.624 24.041 51.5151.000 26.71ANISOU 527 NALA 65 1907 27705472 189936-556ATOM 528 CA ALA 65 -17.522 24.661 50.1991.000 24.91ANISOU 528 CA ALA 65 1798 23795288 280417-754ATOM 529 CALA 65 -16.109 24.575 49.5951.000 21.81ANISOU 529 CALA 65 1808 24084071 597155-626ATOM 530 OALA 65 -15.935 24.724 48.3811.000 24.13ANISOU 530 OALA 65 2127 30763964 224-220 -485ATOM 531 CB ALA 65 -18.023 26.096 50.2211.000 31.78ANISOU 531 CB ALA 65 3096 29845993 1337 1401 -453ATOM 532 NVAL 66 -15.098 24.306 50.4261.000 19.29ANISOU 532 NVAL 66 1836 18803614 466360-541ATOM 533 CA VAL 66 -13.723 24.167 49.9531.000 18.17ANISOU 533 CA VAL 66 1636 16533616 20479 -487ATOM 534 CVAL 66 -13.166 22.767 50.2481.000 15.18ANISOU 534 CVAL 66 1516 16382613 120126-571ATOM 535 OVAL 66 -11.959 22.623 50.3531.000 17.63ANISOU 535 OVAL 66 1567 20713060 217-106 -317ATOM 536 CB VAL 66 -12.784 25.277 50.4371.000 18.91ANISOU 536 CB VAL 66 2175 15763433 183-135 -598ATOM 537 CG1 VAL 66 -13.139 26.627 49.8051.000 20.60ANISOU 537 CG1 VAL 66 2067 17514010 219593-83ATOM 538 CG2 VAL 66 -12.736 25.373 51.9451.000 21.61ANISOU 538 CG2 VAL 66 2689 20663455 10222 -603ATOM 539 NTHR 67 -14.048 21.792 50.3431.000 18.30ANISOU 539 NTHR 67 1761 16143577 -20-6 -514ATOM 540 CA THR 67 -13.673 20.403 50.5631.000 17.18ANISOU 540 CA THR 67 1927 16562946 -3250 -556ATOM 541 CTHR 67 -13.979 19.566 49.3321.000 16.52ANISOU 541 CTHR 67 1763 17422773 21 27 -467ATOM 542 OTHR 67 -15.107 19.613 48.8111.000 18.13ANISOU 542 OTHR 67 1750 22112929 73 -86-383ATOM 543 CB THR 67 -14.373 19.791 51.7821.000 18.54ANISOU 543 CB THR 67 2202 20142827 192224-492ATOM 544 OG1 THR 67 -14.060 20.554 52.9611.000 20.14ANISOU 544 OG1 THR 67 2481 22512920 -108 155-468ATOM 545 CG2 THR 67 -13.912 18.364 52.0171.000 20.04ANISOU 545 CG2 THR 67 2393 20163203 29 -86-235ATOM 546 NSER 68 -13.030 18.818 48.8211.000 16.71ANISOU 546 NSER 68 1612 17203018 -135 154-498ATOM 547 CA SER 68 -13.281 17.947 47.6881.000 16.33ANISOU 547 CA SER 68 1508 16313065 -184 365-561ATOM 548 CSER 68 -14.223 16.795 48.0571.000 14.85ANISOU 548 CSER 68 1194 17752672 -81197-448ATOM 549 OSER 68 -14.303 16.431 49.2331.000 16.36ANISOU 549 OSER 68 1783 17752659 -145 192-481ATOM 550 CB SER 68-11.958 17.303 47.2571.00017.84ANISOU 550 CB SER 6814592139 3182 -87 647-313ATOM 551 OG SER 68-10.998 18.259 46.9041.00017.21ANISOU 551 OG SER 6816591987 2893 -75 364-49ATOM 552 NPRO 69-14.929 16.284 47.0541.00015.89ANISOU 552 NPRO 6915741661 2803 -201 -103 -280ATOM 553 CA PRO 69-15.877 15.182 47.3391.00016.42ANISOU 553 CA PRO 6914281903 2908 -251 -148 -218ATOM 554 CPRO 69-15.168 13.889 47.6841.00017.22ANISOU 554 CPRO 6916331578 3331 -199 266-424ATOM 555 OPRO 69-15.794 12.997 48.2871.00018.35ANISOU 555 OPRO 6918151760 3399 -365 232-376ATOM 556 CB PRO 69-16.712 15.057 46.0601.00016.75ANISOU 556 CB PRO 6913542279 2733 -360 155-729ATOM 557 CG PRO 69-15.799 15.637 45.0081.00016.72ANISOU 557 CG PRO 6915531971 2827 -359 38 -452ATOM 558 CD PRO 69-15.059 16.797 45.6811.00017.10ANISOU 558 CD PRO 6919181804 2776 -344 -119 -313ATOM 559 NVAL 70-13.884 13.746 47.3661.00018.07ANISOU 559 NVAL 7017161764 3384 -89 292-215ATOM 560 CA VAL 70-13.100 12.594 47.8241.00017.34ANISOU 560 CA VAL 7017631851 2974 -20 260-196ATOM 561 CVAL 70-11.995 13.142 48.7201.00017.59ANISOU 561 CVAL 7022071686 2788 -180 159-142ATOM 562 OVAL 70-11.431 14.186 48.3891.00018.59ANISOU 562 OVAL 7017941688 3581 -4 9 152ATOM 563 CB VAL 70-12.429 11.757 46.7241.00018.10ANISOU 563 CB VAL 7019221756 3199 -353 560-446ATOM 564 CG1 VAL 70-13.441 10.754 46.2131.00020.54ANISOU 564 CG1 VAL 7019272611 3268 -369 76 -663ATOM 565 CG2 VAL 70-11.760 12.608 45.6421.00017.65ANISOU 565 CG2 VAL 7023791806 2520 145 9 10ATOM 566 NPRO 71-11.697 12.466 49.8151.00016.21ANISOU 566 NPRO 7116531810 2695 -34 464-156ATOM 567 CA PRO 71-10.839 13.091 50.8331.00017.32ANISOU 567 CA PRO 7117951931 2854 -121 184-12ATOM 568 CPRO 71-9.356 12.804 50.5901.00017.67ANISOU 568 CPRO 7118651927 2921 46 -57156ATOM 569 OPRO 71-8.585 12.223 51.3501.00020.57ANISOU 569 OPRO 7122182247 3350 424 28 474ATOM 570 CB PRO 71-11.362 12.458 52.1171.00019.76ANISOU 570 CB PRO 7129761862 2668 -347 479-304ATOM 571 CG PRO 71-11.721 11.056 51.6701.00019.08ANIS0U 571 CG PRO 7128381805 2608 -267 259-234ATOM 572 CD PRO 71-12.323 11.220 50.2861.00017.97ANISOU 572 CD PRO 7123141974 2538 -390 451-167ATOM 573 NTHR 72-8.894 13.338 49.4461.00017.15ANISOU 573 NTHR 7216772231 2610 -215 -17 -165ATOM 574 CA THR 72-7.573 13.012 48.9351.00016.83ANISOU 574 CA THR 7217211863 2810 -60 -134 -472ATOM 575 CTHR 72-6.490 14.000 49.3581.00015.20ANISOU 575 CTHR 7217911623 2362 -304 163-73ATOM 576 OTHR 72-5.320 13.729 49.1041.00017.49ANISOU 576 OTHR 7217761961 2908 -61 -31-225ATOM 577 CB THR 72-7.533 12.971 47.3991.00016.18ANISOU 577 CB THR 7215521848 2748 -146 -86-261ATOM 578 OG1 THR 72-8.091 14.238 47.0051.00017.81ANISOU 578 OG1 THR 7218561880 3031 -34 115-191ATOM 579 CG2 THR 72-8.338 11.816 46.8251.00017.49ANISOU 579 CG2 THR 7219532087 2605 -550 181-329ATOM 580 NMET 73-6.877 15.098 49.9871.00017.78ANISOU 580 N MET 73 2057 1748 2951 -58 -254 -426ATOM 581 CA MET 73 -5.867 16.117 50.394 1.000 16.58ANISOU 581 CA MET 73 1796 1708 2797 88 -302 -340ATOM 582 C MET 73 -5.073 16.618 49.198 1.000 16.65ANISOU 582 C MET 73 1514 1787 3027 241 -162 -420ATOM 583 O MET 73 -3.911 17.039 49.292 1.000 19.39ANISOU 583 O MET 73 1705 2313 3348 -112-240 -540ATOM 584 CB MET 73 -4.925 15.531 51.469 1.000 20.56ANISOU 584 CB MET 73 2099 2629 3083 345 -507 -286ATOM 585 CG MET 73 -5.703 15.154 52.715 1.000 30.33ANISOU 585 CG MET 73 3008 5133 3384 -69 -609 1027ATOM 586 SD MET 73 -4.692 14.263 53.891 1.000 36.13ANISOU 586 SD MET 73 4121 5050 4558 336 -918 1596ATOM 587 CE MET 73 -3.165 13.987 53.082 1.000 58.07ANISOU 587 CE MET 73 2810 8820 10435975 -1592 -3138ATOM 588 N ARG 74 -5.687 16.632 48.025 1.000 16.83ANISOU 588 N ARG 74 1699 1714 2982 -6 -211 131ATOM 589 CA ARG 74 -5.099 17.215 46.817 1.000 15.87ANISOU 589 CA ARG 74 1365 1618 3046 -17 52 -325ATOM 590 C ARG 74 -5.359 18.714 46.761 1.000 14.22ANISOU 590 C ARG 74 1484 1651 2269 141 -32-42ATOM 591 O ARG 74 -4.472 19.488 46.353 1.000 15.45ANISOU 591 O ARG 74 1525 1758 2586 -12 -46-73ATOM 592 CB ARG 74 -5.675 16.530 45.566 1.000 15.68ANISOU 592 CB ARG 74 1330 1667 2959 160 -14-311ATOM 593 CG ARG 74 -4.890 16.941 44.299 1.000 16.46ANISOU 593 CG ARG 74 1325 1870 3059 -17555 -395ATOM 594 CD ARG 74 -5.655 16.396 43.072 1.000 16.37ANISOU 594 CD ARG 74 1789 1533 2899 -181-8 -177ATOM 595 NE ARG 74 -4.840 16.601 41.857 1.000 19.21ANISOU 595 NE ARG 74 2289 1990 3020 -142241-156ATOM 596 CZ ARG 74 -4.944 17.626 41.039 1.000 17.00ANISOU 596 CZ ARG 74 1545 2351 2562 -67 26 -147ATOM 597 NH1 ARG 74 -5.878 18.573 41.213 1.000 18.00ANISOU 597 NH1 ARG 74 1818 2383 2638 51 -66-220ATOM 598 NH2 ARG 74 -4.144 17.703 39.987 1.000 20.50ANISOU 598 NH2 ARG 74 2285 2972 2532 -110310-387ATOM 599 N ARG 75 -6.579 19.151 47.101 1.000 15.28ANISOU 599 N ARG 75 1755 1544 2507 137 340-173ATOM 600 CA ARG 75 -6.999 20.550 46.980 1.000 14.68ANISOU 600 CA ARG 75 1679 1627 2272 236 98 -150ATOM 601 C ARG 75 -7.956 20.869 48.122 1.000 14.75ANISOU 601 C ARG 75 1445 1747 2414 124 133-233ATOM 602 O ARG 75 -8.760 19.989 48.460 1.000 18.12ANISOU 602 O ARG 75 1677 2109 3101 -156458-433ATOM 603 CB ARG 75 -7.747 20.804 45.668 1.000 15.59ANISOU 603 CB ARG 75 1577 2030 2317 1 46 -106ATOM 604 CG ARG 75 -6.848 20.634 44.441 1.000 15.63ANISOU 604 CG ARG 75 1495 2110 2334 9 147220ATOM 605 CD ARG 75 -5.712 21.618 44.334 1.000 15.59ANISOU 605 CD ARG 75 1658 1792 2475 11 130-10ATOM 606 NE ARG 75 -5.061 21.601 43.011 1.000 15.25ANISOU 606 NE ARG 75 1421 1779 2596 122 227144ATOM 607 CZ ARG 75 -3.957 20.865 42.732 1.000 14.90ANISOU 607 CZ ARG 75 1079 2361 2221 71 -86242ATOM 608 NH1 ARG 75 -3.405 20.091 43.664 1.000 16.18ANISOU 608 NH1 ARG 75 1804 1722 2623 -134-387 337ATOM 609 NH2 ARG 75 -3.418 20.940 41.518 1.000 15.83ANISOU 609 NH2 ARG 75 1677 2107 2232 -1932210ATOM 610 N GLY 76 -7.895 22.086 48.651 1.000 16.06ANISOU 610 N GLY 76 1686 1904 2513 109 220-464ATOM 611 CA GLY 76 -8.858 22.532 49.6371.00016.67ANISOU 611 CA GLY 76 165022602425 -70 199-612ATOM 612 C GLY 76 -8.602 22.002 51.0361.00016.32ANISOU 612 C GLY 76 158420142602 -126 268-347ATOM 613 O GLY 76 -7.469 21.651 51.3701.00016.87ANISOU 613 O GLY 76 163819982773 -45 308-218ATOM 614 N PHE 77 -9.643 22.025 51.8631.00016.88ANISOU 614 N PHE 77 159721412675 -7 283-191ATOM 615 CA PHE 77 -9.584 21.646 53.2741.00017.61ANISOU 615 CA PHE 77 183821962656 109 328-114ATOM 616 C PHE 77 -9.776 20.154 53.5121.00017.64ANISOU 616 C PHE 77 185522482600 -68 243-185ATOM 617 O PHE 77 -10.589 19.528 52.8311.00018.23ANISOU 617 O PHE 77 184424882594 -183 357-240ATOM 618 CB PHE 77 -10.698 22.383 53.9981.00017.70ANISOU 618 CB PHE 77 173025152480 162 65 -344ATOM 619 CG PHE 77 -10.877 22.081 55.4731.00019.61ANISOU 619 CG PHE 77 240525302515 195 261-516ATOM 620 CD1PHE 77 -9.966 22.594 56.3951.00022.27ANISOU 620 CD1PHE 77 251435232426 431 -23-527ATOM 621 CD2PHE 77 -11.917 21.285 55.9411.00021.31ANISOU 621 CD2PHE 77 328220702743 36 615-288ATOM 622 CE1PHE 77 -10.116 22.294 57.7421.00021.05ANISOU 622 CE1PHE 77 271927682510 171 221-339ATOM 623 CE2PHE 77 -12.079 20.991 57.3001.00025.09ANISOU 623 CE2PHE 77 296741202447 -501 625-826ATOM 624 CZ PHE 77 -11.175 21.523 58.2071.00023.79ANISOU 624 CZ PHE 77 226336813095 -1 376-756ATOM 625 N THR 78 -9.022 19.631 54.4901.00017.64ANISOU 625 N THR 78 161621612925 37 3361ATOM 626 CA THR 78 -9.296 18.279 54.9831.00018.12ANISOU 626 CA THR 78 192622432717 -157 624-28ATOM 627 C THR 78 -9.291 18.316 56.5051.00018.66ANISOU 627 C THR 78 212023082663 -367 519-288ATOM 628 O THR 78 -8.335 18.821 57.0951.00021.42ANISOU 628 O THR 78 215828833098 -432 90 177ATOM 629 CB THR 78 -8.252 17.242 54.5211.00021.00ANISOU 629 CB THR 78 297320672939 113 428-574ATOM 630 OG1THR 78 -8.027 17.392 53.1041.00021.18ANISOU 630 OG1THR 78 254426712833 160 317-773ATOM 631 CG2THR 78 -8.735 15.832 54.8001.00026.65ANISOU 631 CG2THR 78 375922274141 -275 853-618ATOM 632 N GLY 79 -10.311 17.804 57.1811.00020.36ANISOU 632 N GLY 79 266923792690 -670 630-144ATOM 633 CA GLY 79 -10.344 17.679 58.6231.00025.96ANISOU 633 CA GLY 79 387132492745 -790 576375ATOM 634 C GLY 79 -10.029 16.238 59.0391.00039.70ANISOU 634 C GLY 79 640735425135 -1658-1944 1511ATOM 635 O GLY 79 -10.623 15.303 58.4911.00031.02ANISOU 635 O GLY 79 432731874272 -404 419-75ATOM 636 N LEU 80 -9.069 16.055 59.9361.00036.07ANISOU 636 N LEU 80 438045364788 1381 -564 -835ATOM 637 CA LEU 80 -8.634 14.713 60.3401.00032.52ANISOU 637 CA LEU 80 364040834632 611 -502 -898ATOM 638 C LEU 80 -9.131 14.311 61.7161.00039.82ANISOU 638 C LEU 80 505146525428 -128 418-538ATOM 639 O LEU 80 -9.998 14.963 62.3051.00037.05ANISOU 639 O LEU 80 505738075213 -292 66687ATOM 640 CB LEU 80 -7.122 14.580 60.2651.00038.36ANISOU 640 CB LEU 80 382154565299 1568 -33-1406ATOM 641 CG LEU 80 -6.488 14.753 58.8831.00038.27ANISOU 641 CG LEU 80 3714 5900 4926 725 -288 -2588ATOM 642 CD1 LEU 80 -5.007 14.359 58.948 1.000 45.41ANISOU 642 CD1 LEU 80 2579 8505 6170 -1092 -7637ATOM 643 CD2 LEU 80 -7.170 13.856 57.854 1.000 40.75ANISOU 643 CD2 LEU 80 4296 5601 5587 872 -1965 -1793ATOM 644 N SER 98 -6.459 17.442 63.930 1.000 36.72ANISOU 644 N SER 98 3404 6429 4118 -2114 -698 1948ATOM 645 CA SER 98 -5.629 17.877 62.824 1.000 39.59ANISOU 645 CA SER 98 6031 5376 3635 -4493832177ATOM 646 C SER 98 -6.402 18.372 61.610 1.000 29.89ANISOU 646 C SER 98 3806 3509 4040 141 6401204ATOM 647 O SER 98 -7.474 17.856 61.304 1.000 38.27ANISOU 647 O SER 98 4936 4300 5303 -1107 395885ATOM 648 CB SER 98 -4.694 16.739 62.358 1.000 44.06ANISOU 648 CB SER 98 3175 7425 6141 633 -753 2704ATOM 649 OG SER 98 -3.672 17.368 61.583 1.000 46.84ANISOU 649 OG SER 98 3497 6502 7797 95 -408 2418ATOM 650 N MET 99 -5.829 19.317 60.869 1.000 28.56ANISOU 650 N MET 99 5029 3458 2365 -1080 -550 546ATOM 651 CA MET 99 -6.426 19.941 59.700 1.000 21.44ANISOU 651 CA MET 99 2284 3549 2315 -182157132ATOM 652 C MET 99 -5.376 20.229 58.624 1.000 19.16ANISOU 652 C MET 99 2306 2592 2382 -43360 137ATOM 653 O MET 99 -4.232 20.575 58.930 1.000 23.34ANISOU 653 O MET 99 2489 3920 2460 -773225-410ATOM 654 CB MET 99 -7.164 21.209 60.105 1.000 25.20ANISOU 654 CB MET 99 3172 3375 3028 -572661-547ATOM 655 CG MET 99 -8.481 20.965 60.872 1.000 25.85ANISOU 655 CG MET 99 3172 3862 2787 -275739-782ATOM 656 SD MET 99 -9.251 22.517 61.389 1.000 32.21ANISOU 656 SD MET 99 4405 3750 4083 -1331580 -568ATOM 657 CE MET 99 -8.884 22.461 63.145 1.000 76.12ANISOU 657 CE MET 99 14782115382603 -3321 3478 -3241ATOM 658 N CYS 100 -5.778 20.094 57.361 1.000 18.85ANISOU 658 N CYS 100 2434 2443 2285 -16093 194ATOM 659 CA CYS 100 -4.868 20.333 56.234 1.000 18.55ANISOU 659 CA CYS 100 2251 2380 2418 92 127236ATOM 660 C CYS 100 -5.496 21.312 55.228 1.000 16.26ANISOU 660 C CYS 100 1826 2031 2321 110 3292ATOM 661 O CYS 100 -6.728 21.308 55.071 1.000 17.69ANISOU 661 O CYS 100 1741 2395 2586 -69 154-104ATOM 662 CB CYS 100 -4.604 18.982 55.545 1.000 18.46ANISOU 662 CB CYS 100 2822 2081 2111 98 118511ATOM 663 SG CYS 100 -3.243 18.974 54.329 1.000 22.76ANISOU 663 SG CYS 100 2622 2968 3058 307 39110ATOM 664 N TYR 101 -4.697 22.069 54.498 1.000 17.49ANISOU 664 N TYR 101 1839 2473 2332 46 291224ATOM 665 CA TYR 101 -5.117 22.874 53.373 1.000 15.38ANISOU 665 CA TYR 101 1946 1939 1960 -50 90 -262ATOM 666 C TYR 101 -4.102 22.594 52.245 1.000 13.65ANISOU 666 C TYR 101 1676 1543 1967 -2 -123 -151ATOM 667 O TYR 101 -2.896 22.629 52.475 1.000 15.95ANISOU 667 O TYR 101 1611 2231 2217 -43 -232 -212ATOM 668 CB TYR 101 -5.122 24.382 53.739 1.000 19.02ANISOU 668 CB TYR 101 2816 2082 2328 234 48 -519ATOM 669 CG TYR 101 -5.617 25.109 52.498 1.000 17.85ANISOU 669 CG TYR 101 2084 1895 2804 18 -26-231ATOM 670 CD1 TYR 101 -6.964 25.134 52.171 1.000 18.25ANISOU 670 CD1 TYR 101 2042 1596 3298 29 28 -496ATOM 671 CD2 TYR 101 -4.730 25.778 51.658 1.000 17.77ANISOU 671 CD2 TYR 101 2037 1611 3106 -46 -125 -127ATOM 672 CE1 TYR 101 -7.406 25.796 51.0361.00019.63ANISOU 672 CE1 TYR 101 197717763704 88 -241 -221ATOM 673 CE2 TYR 101 -5.147 26.386 50.4781.00020.46ANISOU 673 CE2 TYR 101 206026083108 239 40 182ATOM 674 CZ TYR 101 -6.504 26.392 50.1661.00020.29ANISOU 674 CZ TYR 101 218723973127 -73 -353 -260ATOM 675 OH TYR 101 -6.932 26.995 49.0001.00023.34ANISOU 675 OH TYR 101 279025553523 -3 -641 52ATOM 676 NSER 102 -4.648 22.210 51.0971.00014.60ANISOU 676 NSER 102 161818902041 -61 -109 -477ATOM 677 CA SER 102 -3.797 21.792 49.9801.00014.52ANISOU 677 CA SER 102 168418022030 -108 62 -276ATOM 678 CSER 102 -4.011 22.670 48.7471.00014.99ANISOU 678 CSER 102 154517902361 -296 -4121ATOM 679 OSER 102 -5.167 23.105 48.4771.00016.73ANISOU 679 OSER 102 158923422425 2128-3ATOM 680 CB SER 102 -4.163 20.340 49.5931.00013.82ANISOU 680 CB SER 102 169215482013 174 9 -138ATOM 681 OG SER 102 -3.996 19.476 50.7201.00016.06ANISOU 681 OG SER 102 188620662153 97 -121 63ATOM 682 NMET 103 -2.978 22.775 47.9201.00014.47ANISOU 682 NMET 103 156817242206 51 -59152ATOM 683 CA MET 103 -3.102 23.552 46.6871.00016.58ANISOU 683 CA MET 103 219419332173 331 -74253ATOM 684 CMET 103 -2.150 23.013 45.6081.00014.41ANISOU 684 CMET 103 159817932083 -202 -210 63ATOM 685 OMET 103 -1.157 22.347 45.9201.00016.24ANISOU 685 OMET 103 152723842259 -61 -23468ATOM 686 CB MET 103 -2.716 25.004 46.8351.00028.78ANISOU 686 CB MET 103 653713183081 859 -207 366ATOM 687 CG MET 103 -3.258 25.986 47.8011.00022.60ANISOU 687 CG MET 103 253121573900 -161 -57-291ATOM 688 SD MET 103 -2.338 27.505 47.5061.00020.60ANISOU 688 SD MET 103 249919273400 -4 -164 -226ATOM 689 CE MET 103 -2.587 27.945 45.8041.00021.63ANISOU 689 CE MET 103 231926013300 308 209-236ATOM 690 NGLY 104 -2.439 23.430 44.3781.00015.44ANISOU 690 NGLY 104 146822282169 -68 -120 164ATOM 691 CA GLY 104 -1.511 23.199 43.2761.00016.13ANISOU 691 CA GLY 104 168822022241 42 65 469ATOM 692 CGLY 104 -1.583 24.355 42.2941.00015.76ANISOU 692 CGLY 104 170619972286 -32 -194 388ATOM 693 OGLY 104 -1.987 25.478 42.6531.00019.06ANISOU 693 OGLY 104 195320323256 -71 144333ATOM 694 NTHR 105 -1.151 24.092 41.0541.00016.73ANISOU 694 NTHR 105 168523852287 -375 -55515ATOM 695 CA THR 105 -1.115 25.205 40.0941.00017.06ANISOU 695 CA THR 105 172523902369 -231 -148 577ATOM 696 CTHR 105 -2.513 25.631 39.6351.00019.55ANISOU 696 CTHR 105 176818173842 -160 -346 525ATOM 697 OTHR 105 -2.680 26.703 39.0591.00022.41ANISOU 697 OTHR 105 226221164136 -119 -520 842ATOM 698 CB THR 105 -0.301 24.857 38.8401.00017.57ANISOU 698 CB THR 105 175928772038 -394 -343 377ATOM 699 OG1 THR 105 -0.865 23.675 38.2171.00018.66ANISOU 699 OG1 THR 105 203524492607 -140 -458 416ATOM 700 CG2 THR 105 1.155 24.590 39.1781.00018.95ANISOU 700 CG2 THR 105 174828532601 -105 -248 296ATOM 701 NALA 106 -3.507 24.751 39.7411.00016.52ANISOU 701 NALA 106 159622932389 -180 -1 298ATOM 702 CA ALA 106 -4.846 25.035 39.2181.00016.59ANISOU 702 CAALA 106 169219522660 -214 -209 243ATOM 703 C ALA 106 -5.848 24.142 39.9231.000 17.52ANISOU 703 C ALA 106 165118213186 26-66555ATOM 704 O ALA 106 -5.479 23.323 40.8051.000 17.88ANISOU 704 O ALA 106 203820872668 59-51388ATOM 705 CBALA 106 -4.862 24.838 37.7131.000 20.31ANISOU 705 CBALA 106 233127642620 -197 -403 440ATOM 706 N ASP 107 -7.149 24.329 39.7171.000 18.00ANISOU 706 N ASP 107 157622083057 -77 -120 49ATOM 707 CAASP 107 -8.217 23.535 40.3441.000 17.46ANISOU 707 CAASP 107 156321912881 -83 -472 363ATOM 708 C ASP 107 -8.173 23.753 41.8591.000 17.74ANISOU 708 C ASP 107 182520442869 447 -269 362ATOM 709 O ASP 107 -8.458 22.854 42.6501.000 18.95ANISOU 709 O ASP 107 199422302974 167 -133 402ATOM 710 CBASP 107 -8.089 22.044 39.9901.000 19.62ANISOU 710 CBASP 107 221323002942 -394 -727 173ATOM 711 CGASP 107 -8.370 21.842 38.5081.000 20.81ANISOU 711 CGASP 107 195230932862 -138 -532 -14ATOM 712 OD1 ASP 107 -9.369 22.369 37.9761.000 25.84ANISOU 712 OD1 ASP 107 252439673327 222 -1149 -240ATOM 713 OD2 ASP 107 -7.544 21.168 37.8441.000 25.86ANISOU 713 OD2 ASP 107 331429893523 391 -91-89ATOM 714 N ASN 108 -7.893 24.962 42.2981.000 18.18ANISOU 714 N ASN 108 204920752786 509 189153ATOM 715 CAASN 108 -7.831 25.263 43.7401.000 17.10ANISOU 715 CAASN 108 180419772715 266 291327ATOM 716 C ASN 108 -9.158 25.716 44.3141.000 17.11ANISOU 716 C ASN 108 170520612734 367 44 149ATOM 717 O ASN 108 -10.103 26.086 43.6041.000 20.72ANISOU 717 O ASN 108 206623773430 759 -248 245ATOM 718 CBASN 108 -6.799 26.379 43.9691.000 19.90ANISOU 718 CBASN 108 177023083483 186 298-171ATOM 719 CGASN 108 -5.400 25.862 43.7171.000 17.24ANISOU 719 CGASN 108 170922122628 200 68 184ATOM 720 OD1 ASN 108 -4.986 24.850 44.2771.000 17.42ANISOU 720 OD1 ASN 108 200319842631 109 11 -62ATOM 721 ND2 ASN 108 -4.644 26.487 42.8341.000 18.41ANISOU 721 ND2 ASN 108 208323262587 -82 300-18ATOM 722 N LEU 109 -9.308 25.509 45.6071.000 18.09ANISOU 722 N LEU 109 179522942786 349 34410ATOM 723 CALEU 109 -10.532 25.803 46.3691.000 19.11ANISOU 723 CALEU 109 176322003296 14476-598ATOM 724 C LEU 109 -10.169 26.790 47.4571.000 17.40ANISOU 724 C LEU 109 168219372990 251 129-207ATOM 725 O LEU 109 -9.443 26.423 48.3951.000 21.18ANISOU 725 O LEU 109 244319223684 174 -520 2ATOM 726 CBLEU 109 -11.100 24.504 46.9401.000 17.10ANISOU 726 CBLEU 109 188821422469 199 426-630ATOM 727 CGLEU 109 -11.520 23.425 45.9441.000 18.07ANISOU 727 CGLEU 109 251519432409 190 -198 -363ATOM 728 CD1 LEU 109 -11.895 22.124 46.6541.000 20.06ANISOU 728 CD1 LEU 109 284224062375 -331 -175 -200ATOM 729 CD2 LEU 109 -12.630 23.908 45.0351.000 25.24ANISOU 729 CD2 LEU 109 348128923217 306 -992 -111ATOM 730 N PHE 110 -10.609 28.036 47.3131.000 17.25ANISOU 730 N PHE 110 158419263045 272 184-132ATOM 731 CAPHE 110 -10.235 29.071 48.2771.000 18.20ANISOU 731 CAPHR 110 175118163346 169 221-160ATOM 732 C PHE 110 -11.409 29.567 49.1061.000 19.93ANISOU 732 C PHE 110 207716093886 71650-335ATOM 733 OPHE 110 -12.433 29.948 48.4941.00024.64ANISOU 733 OPHE 110 2051 2461 4851 612 328-779ATOM 734 CB PHE 110 -9.60730.243 47.5201.00019.92ANISOU 734 CB PHE 110 2367 1876 3324 224 619-93ATOM 735 CG PHE 110 -8.38029.986 46.6881.00019.47ANISOU 735 CG PHE 110 2009 2209 3179 -321 327-791ATOM 736 CD1 PHE 110 -7.17729.680 47.2871.00020.59ANISOU 736 CD1 PHE 110 2071 2080 3674 -274 236-331ATOM 737 CD2 PHE 110 -8.43730.035 45.2991.00020.19ANISOU 737 CD2 PHE 110 2557 1914 3200 112 543-289ATOM 738 CE1 PHE 110 -6.03429.454 46.5591.00021.06ANISOU 738 CE1 PHE 110 2020 2309 3673 -386 165-622ATOM 739 CE2 PHE 110 -7.27729.811 44.5471.00020.77ANISOU 739 CE2 PHE 110 2495 2138 3257 197 504-398ATOM 740 CZ PHE 110 -6.08129.518 45.1751.00022.42ANISOU 740 CZ PHE 110 2747 2092 3678 531 339-357ATOM 741 NPRO 111 -11.238 29.718 50.4161.00022.11ANISOU 741 NPRO 111 2250 2153 3996 -72 871-620ATOM 742 CA PRO 111 -12.287 30.389 51.1951.00028.23ANISOU 742 CA PRO 111 3895 2210 4621 698 1514 -671ATOM 743 CPRO 111 -12.333 31.866 50.7841.00030.57ANISOU 743 CPRO 111 4528 2026 5061 410 410-1041ATOM 744 OPRO 111 -11.390 32.340 50.1151.00031.71ANISOU 744 OPRO 111 4040 2236 5774 -179 -597 -12ATOM 745 CB PRO 111 -11.799 30.250 52.6271.00033.20ANISOU 745 CB PRO 111 5609 2702 4303 671 1671 -790ATOM 746 CG PRO 111 -10.646 29.326 52.6471.00026.04ANISOU 746 CG PRO 111 2742 3316 3835 -931 1324 -192ATOM 747 CD PRO 111 -10.161 29.149 51.2301.00022.15ANISOU 747 CD PRO 111 2587 2307 3522 -471 541-623ATOM 748 NSER 112 -13.337 32.641 51.1501.00042.13ANISOU 748 NSER 112 7176 2716 6115 2074 1731 -526ATOM 749 CA SER 112 -13.368 34.026 50.6721.00044.05ANISOU 749 CA SER 112 6799 2255 7684 1107 -485 -826ATOM 750 CSER 112 -13.262 34.157 49.1491.00068.28ANISOU 750 CSER 112 13632 4498 7812 -1855-2077 1301ATOM 751 OSER 112 -12.347 34.825 48.6461.00095.18ANISOU 751 OSER 112 15991 114258747 -4337-701985ATOM 752 CB SER 112 -12.493 35.069 51.3491.00039.31ANISOU 752 CB SER 112 2247 4535 8153 580 1662 -1437ATOM 753 OG SER 112 -11.474 34.624 52.2131.00037.49ANISOU 753 OG SER 112 7213 2453 4579 806 747-1152ATOM 754 NASP 114 -9.51537.322 49.9451.00036.40ANISOU 754 NASP 114 3476 2118 8237 1254 4031484ATOM 755 CA ASP 114 -8.20537.586 50.6001.00030.79ANISOU 755 CA ASP 114 3503 2856 5340 1229 1240 996ATOM 756 CASP 114 -7.24236.402 50.6481.00026.16ANISOU 756 CASP 114 2581 2404 4955 601 1114 804ATOM 757 OASP 114 -6.03136.458 50.3381.00025.45ANISOU 757 OASP 114 2302 2503 4866 -43 602131ATOM 758 CB ASP 114 -8.59537.874 52.0751.00043.68ANISOU 758 CB ASP 114 7509 2783 6304 1157 2727 -210ATOM 759 CG ASP 114 -7.39138.386 52.8351.00046.96ANISOU 759 CG ASP 114 9259 3225 5359 2517 519107ATOM 760 OD1 ASP 114 -6.48738.959 52.1891.00083.49ANISOU 760 OD1 ASP 114 13724 9866 8132 -6354650-3056ATOM 761 OD2 ASP 114 -7.37038.262 54.0711.000113.59ANISOU 761 OD2 ASP 114 27880 105504730 -6984-159 -2575ATOM 762 NPHE 115 -7.83135.323 51.1531.00022.32ANISOU 762 NPHE 115 2620 2062 3799 204 954-114ATOM 763 CA PHE 115 -7.11534.026 51.1831.00022.69ANISOU 763 CA PHE 115 276519093947 118 1093 -187ATOM 764 CPHE 115 -6.502 33.754 49.8161.00021.49ANISOU 764 CPHE 115 214623163702 305 559-255ATOM 765 OPHE 115 -5.328 33.362 49.7581.00020.51ANISOU 765 OPHE 115 215320113627 323 488-158ATOM 766 CB PHE 115 -8.096 32.928 51.6381.00020.76ANISOU 766 CB PHE 115 236919463574 -3 563-473ATOM 767 CG PHE 115 -7.496 31.590 51.9981.00020.23ANISOU 767 CG PHE 115 236918543463 -155 629-377ATOM 768 CD1 PHE 115 -6.915 30.756 51.0411.00020.35ANISOU 768 CD1 PHE 115 257217863372 -195 112-756ATOM 769 CD2 PHE 115 -7.474 31.152 53.3091.00021.11ANISOU 769 CD2 PHE 115 280219323287 -113 17 -689ATOM 770 CE1 PHE 115 -6.351 29.538 51.3251.00021.09ANISOU 770 CE1 PHE 115 250217283784 -295 471-538ATOM 771 CE2 PHE 115 -6.938 29.901 53.6231.00027.40ANISOU 771 CE2 PHE 115 501219553445 444 43 -572ATOM 772 CZ PHE 115 -6.332 29.110 52.6551.00024.92ANISOU 772 CZ PHE 115 335618894222 50 1519 221ATOM 773 NGLU 116 -7.301 33.768 48.7571.00021.64ANISOU 773 NGLU 116 239618353990 338 261-13ATOM 774 CA GLU 116 -6.750 33.424 47.4441.00020.90ANISOU 774 CA GLU 116 223519653742 224 74 116ATOM 775 CGLU 116 -5.550 34.262 47.0541.00020.32ANISOU 775 CGLU 116 197818993845 439 -108 448ATOM 776 OGLU 116 -4.544 33.679 46.6041.00020.18ANISOU 776 OGLU 116 220921473312 424 73 139ATOM 777 CB GLU 116 -7.851 33.561 46.3851.00024.22ANISOU 777 CB GLU 116 242526384139 -467 -237 519ATOM 778 CG GLU 116 -7.339 33.331 44.9801.00023.27ANISOU 778 CG GLU 116 242524653952 -7 -494 750ATOM 779 CD GLU 116 -8.401 33.273 43.9101.00025.02ANISOU 779 CD GLU 116 269527034107 -510 -739 1509ATOM 780 OE1 GLU 116 -9.617 33.306 44.2071.00034.83ANISOU 780 OE1 GLU 116 246646066161 -203 -928 1566ATOM 781 OE2 GLU 116 -8.001 33.030 42.7631.00040.92ANISOU 781 OE2 GLU 116 438971723988 -24 -968 693ATOM 782 NARG 117 -5.549 35.571 47.3001.00020.60ANISOU 782 NARG 117 229918113718 382 -10469ATOM 783 CA ARG 117 -4.374 36.374 46.8661.00022.65ANISOU 783 CA ARG 117 223017914586 351 107153ATOM 784 CARG 117 -3.163 35.911 47.6481.00021.87ANISOU 784 CARG 117 226918654178 252 17997ATOM 785 OARG 117 -2.060 35.789 47.1021.00022.10ANISOU 785 OARG 117 219722703931 216 41 205ATOM 786 CB ARG 117 -4.682 37.861 47.1051.00029.47ANISOU 786 CB ARG 117 284916916658 259 -555 -1ATOM 787 CG ARG 117 -3.485 38.815 47.0461.00040.24ANISOU 787 CG ARG 117 390525678818 -819 -1330 -476ATOM 788 CD ARG 117 -3.745 40.160 47.7161.00052.75ANISOU 788 CD ARG 117 4698284812496 -595 -1653 -1669ATOM 789 NE ARG 117 -3.934 39.987 49.1551.00068.00ANISOU 789 NE ARG 117 8247471912872 422 1842 -3441ATOM 790 CZ ARG 117 -3.166 40.448 50.1261.00078.38ANISOU 790 CZ ARG 117 13026 565811097 283 448-2498ATOM 791 NH1 ARG 117 -2.097 41.186 49.8491.00089.01ANISOU 791 NH1 ARG 117 14218 11488 8115 -3550-6761 3577ATOM 792 NH2 ARG 117 -3.479 40.189 51.3911.00082.58ANISOU 792 NH2 ARG 117 16575 285611947 2617 2551 -2095ATOM 793 NILE 118 -3.334 35.759 48.9541.00021.70ANISOU 793 NILE 118 231917974127 311 271-314ATOM 794 CA ILE 118 -2 206 35.425 49.810 1.000 20.99ANISOU 794 CA ILE 118 2546 1624 3805 408 294-470ATOM 795 C ILE 118 -1.596 34.073 49.475 1.000 18.79ANISOU 795 C ILE 118 2222 1534 3384 218 573-201ATOM 796 O ILE 118 -0.409 33.858 49.323 1.000 17.27ANISOU 796 O ILE 118 2194 1663 2707 283 351-136ATOM 797 CB ILE 118 -2.588 35.542 51.293 1.000 22.62ANISOU 797 CB ILE 118 2702 1997 3895 276 416-856ATOM 798 CG1 ILE 118 -2.916 36.995 51.700 1.000 27.54ANISOU 798 CG1 ILE 118 5077 1801 3587 503 768-401ATOM 799 CG2 ILE 118 -1.552 34.940 52.206 1.000 23.59ANISOU 799 CG2 ILE 118 3084 2274 3606 183 254-818ATOM 800 CD1 ILE 118 -3.493 37.115 53.096 1.000 29.35ANISOU 800 CD1 ILE 118 5212 2054 3885 558 1114 -645ATOM 801 N TRP 119 -2.454 33.069 49.341 1.000 17.93ANISOU 801 N TRP 119 2378 1605 2828 147 -80-26．9ATOM 802 CA TRP 119 -2.035 31.688 49.103 1.000 16.57ANISOU 802 CA TRP 119 2126 1538 2630 152 -25-16ATOM 803 C TRP 119 -1.575 31.476 47.676 1.000 16.98ANISOU 803 C TRP 119 2126 1723 2604 269 -91-51ATOM 804 O TRP 119 -0.700 30.640 47.455 1.000 17.58ANISOU 804 O TRP 119 1892 1674 3113 135 18163ATOM 805 CB TRP 119 -3.127 30.690 49.591 1.000 18.32ANISOU 805 CB TRP 119 2156 1789 3014 -34 5 -7ATOM 806 CG TRP 119 -2.934 30.457 51.082 1.000 18.27ANISOU 806 CG TRP 119 2208 1711 3025 86 34956ATOM 807 CD1 TRP 119 -3.354 31.273 52.103 1.000 20.36ANISOU 807 CD1 TRP 119 2624 2029 3083 156 276-153ATOM 808 CD2 TRP 119 -2.213 29.383 51.683 1.000 18.61ANISOU 808 CD2 TRP 119 2049 2055 2967 134 263110ATOM 809 NE1 TRP 119 -2.955 30.773 53.323 1.000 20.55ANISOU 809 NE1 TRP 119 2471 2229 3109 92 266-106ATOM 810 CE2 TRP 119 -2.260 29.603 53.073 1.000 20.21ANISOU 810 CE2 TRP 119 2529 2258 2893 180 754297ATOM 811 CE3 TRP 119 -1.576 28.258 51.147 1.000 18.29ANISOU 811 CE3 TRP 119 2258 1714 2977 42 -70-20ATOM 812 CZ2 TRP 119 -1.636 28.728 53.981 1.000 21.97ANISOU 812 CZ2 TRP 119 2876 2526 2945 384 51 -106ATOM 813 CZ3 TRP 119 -0.968 27.375 52.045 1.000 19.35ANISOU 813 CZ3 TRP 119 2576 2028 2750 187 415299ATOM 814 CH2 TRP 119 -1.026 27.618 53.442 1.000 21.67ANISOU 814 CH2 TRP 119 3033 2379 2823 350 25097ATOM 815 N THR 120 -2.129 32.192 46.701 1.000 16.93ANISOU 815 N THR 120 2023 1833 2577 122 -112 18ATOM 816 CA THR 120 -1.598 32.086 45.342 1.000 17.85ANISOU 816 CA THR 120 1915 2469 2398 222 -371 -324ATOM 817 C THR 120 -0.169 32.587 45.288 1.000 17.15ANISOU 817 C THR 120 2031 1855 2629 241 -155 192ATOM 818 O THR 120 0.70031.960 44.674 1.000 18.67ANISOU 818 O THR 120 1996 1887 3212 389 -131 177ATOM 819 CB THR 120 -2.487 32.865 44.344 1.000 18.10ANISOU 819 CB THR 120 1951 2204 2720 28 -93345ATOM 820 OG1 THR 120 -3.773 32.238 44.284 1.000 20.49ANISOU 820 OG1 THR 120 1807 2801 3179 59 -363 558ATOM 821 CG2 THR 120 -1.919 32.803 42.933 1.000 22.46ANISOU 821 CG2 THR 120 2438 3266 2830 475 118705ATOM 822 N GLN 121 0.09433.708 45.956 1.000 18.62ANISOU 822 N GLN 121 2180 1657 3237 123 -94213ATOM 823 CA GLN 121 1.46634.232 45.993 1.000 18.15ANISOU 823 CA GLN 121 2077 1698 3119 77 96 520ATOM 824 C GLN 121 2.41233.284 46.718 1.000 17.04ANISOU 824 CGLN 121 2022 14313019 192 234223ATOM 825 OGLN 121 3.510 33.047 46.2701.00019.32ANISOU 825 OGLN 121 1894 18003645 93 246129ATOM 826 CB GLN 121 1.490 35.579 46.7561.00022.90ANISOU 826 CB GLN 121 2520 14794702 327 -812 271ATOM 827 CG GLN 121 2.888 36.159 46.8711.00027.04ANISOU 827 CG GLN 121 2949 20625262 -346 -400 132ATOM 828 CD GLN 121 3.530 36.511 45.5351.00031.94ANISOU 828 CD GLN 121 3307 27336097 983 1031 99ATOM 829 OE1 GLN 121 4.660 36.085 45.2471.00062.76ANISOU 829 OE1 GLN 121 3009 957011267 1758 2366 2029ATOM 830 NE2 GLN 121 2.859 37.306 44.7161.00055.89ANISOU 830 NE2 GLN 121 6516 77286993 2815 1745 3249ATOM 831 NTYR 122 1.997 32.791 47.8711.00016.87ANISOU 831 NTYR 122 2389 15182501 71 -161 -54ATOM 832 CA TYR 122 2.795 31.881 48.6831.00017.97ANISOU 832 CA TYR 122 2564 16002666 176 -224 -56ATOM 833 CTYR 122 3.080 30.600 47.9091.00016.83ANISOU 833 CTYR 122 1870 14603065 -31 -57-98ATOM 834 OTYR 122 4.224 30.129 47.8231.00017.67ANISOU 834 OTYR 122 1891 19522872 189 -220 126ATOM 835 CB TYR 122 2.018 31.522 49.9601.00018.01ANISOU 835 C8 TYR 122 2526 18212495 2-325 -55ATOM 836 CG TYR 122 2.753 30.619 50.8981.00017.89ANISOU 836 CG TYR 122 2332 16952769 255 -147 -51ATOM 837 CD1 TYR 122 4.058 30.901 51.3231.00021.71ANISOU 837 CD1 TYR 122 2883 21013267 -257 -913 34ATOM 838 CD2 TYR 122 2.107 29.496 51.4151.00021.29ANISOU 838 CD2 TYR 122 2428 20263634 128 -267 468ATOM 839 CE1 TYR 122 4.680 30.037 52.2121.00021.27ANISOU 839 CE1 TYR 122 2681 20453356 140 -725 -210ATOM 840 CE2 TYR 122 2.746 28.637 52.2901.00024.50ANISOU 840 CE2 TYR 122 3376 18764057 -292 -1163 506ATOM 841 CZ TYR 122 4.043 28.914 52.6751.00022.16ANISOU 841 CZ TYR 122 3161 18813379 95 -909 -128ATOM 842 OH TYR 122 4.699 28.079 53.5661.00023.72ANISOU 842 OH TYR 122 3471 23983142 52 -1005 -56ATOM 843 NPHE 123 2.074 30.023 47.2531.00016.21ANISOU 843 NPHE 123 1794 15712793 49 -66-54ATOM 844 CA PHE 123 2.347 28.843 46.3971.00015.71ANISOU 844 CA PHE 123 1622 18002548 34 -142 -103ATOM 845 CPHE 123 3.378 29.188 45.3371.00015.96ANISOU 845 CPHE 123 1681 13043078 42 90 3ATOM 846 OPHE 123 4.276 28.375 45.0371.00015.47ANISOU 846 OPHE 123 1703 14372739 54 14 -24ATOM 847 CB PHE 123 1.036 28.309 45.7791.00015.07ANISOU 847 CB PHE 123 1460 13642904 209 -148 1ATOM 848 CG PHE 123 1.241 27.104 44.8791.00017.41ANISOU 848 CG PHE 123 2090 16202906 -39 -179 -238ATOM 849 CD1 PHE 123 1.170 25.831 45.4521.00017.41ANISOU 849 CD1 PHE 123 1680 14393494 72 -119 -255ATOM 850 CD2 PHE 123 1.490 27.259 43.5131.00018.22ANISOU 850 CD2 PHE 123 1723 23312870 -96 -216 -372ATOM 851 CE1 PHE 123 1.419 24.740 44.6361.00019.15ANISOU 851 CE1 PHE 123 2112 17663397 212 -540 -536ATOM 852 CE2 PHE 123 1.722 26.144 42.7171.00019.63ANISOU 852 CE2 PHE 123 1901 24763083 -134 -261 -632ATOM 853 CZ PHE 123 1.635 24.868 43.2741.00019.40ANISOU 853 CZ PHE 123 1525 24243421 385 -529 -490ATOM 854 NASP 124 3.164 30.304 44.6361.00016.86ANISOU 854 NASP 124 1947 14662992 -23 -110 124ATOM855 CA ASP 124 4.06030.640 43.544 1.000 17.82ANISOU 855 CA ASP 124 2103 1747 2921 405 -24314ATOM856 CASP 124 5.49030.733 44.024 1.000 17.52ANISOU 856 CASP 124 1999 1439 3219 181 94 89ATOM857 OASP 124 6.40230.324 43.317 1.000 17.18ANISOU 857 OASP 124 2086 1427 3015 34 181177ATOM858 CB AASP 124 3.63931.997 42.942 0.534 21.77ANISOU 858 CB AASP 124 3475 2089 2706 642 -372 597ATOM859 CG AASP 124 4.38132.304 41.659 0.534 19.28ANISOU 859 CG AASP 124 2376 1982 2967 173 -553 495ATOM860 OD1 AASP 124 4.22331.538 40.678 0.534 21.03ANISOU 860 OD1 AASP 124 2189 2636 3164 -28 76 21ATOM861 OD2 AASP 124 5.06833.348 41.639 0.534 24.96ANISOU 861 OD2 AASP 124 3681 2052 3752 -296-1067 889ATOM862 CB BASP 124 3.63231.975 42.908 0.466 19.67ANISOU 862 CB BASP 124 2559 1993 2923 1003673446ATOM863 CG BASP 124 2.36831.849 42.089 0.466 22.78ANISOU 863 CG BASP 124 3552 3217 1889 872 1771175ATOM864 OD1 BASP 124 2.02130.781 41.545 0.466 27.78ANISOU 864 OD1 BASP 124 2138 3932 4483 100 503347ATOM865 OD2 BASP 124 1.70332.893 41.902 0.466 29.73ANISOU 865 OD2 BASP 124 3845 3804 3646 1239-312 1644ATOM866 NARG 125 5.66931.416 45.153 1.000 16.65ANISOU 866 NARG 125 1942 1350 3032 276 139276ATOM867 CA ARG 125 7.03831.528 45.646 1.000 17.58ANISOU 867 CA ARG 125 1918 1819 2944 98 177241ATOM868 CARG 125 7.66230.188 45.992 1.000 17.38ANISOU 868 CARG 125 1544 1777 3282 -42 40 273ATOM869 OARG 125 8.84129.942 45.754 1.000 18.26ANISOU 869 OARG 125 1639 1669 3631 -97 91 -233ATOM870 CB ARG 125 7.06232.468 46.851 1.000 20.45ANISOU 870 CB ARG 125 2219 2162 3387 -244450-274ATOM871 CG ARG 125 6.86033.916 46.344 1.000 28.23ANISOU 871 CG ARG 125 3178 2007 5542 147 666-222ATOM872 CD ARG 125 6.69334.891 47.477 1.000 31.76ANISOU 872 CD ARG 125 3065 2279 6725 -6281455 -993ATOM873 NE ARG 125 6.49636.221 46.932 1.000 40.81ANISOU 873 NE ARG 125 3332 2095 10080-1691790 -694ATOM874 CZ ARG 125 5.97037.229 47.628 1.000 43.42ANISOU 874 CZ ARG 125 4531 2891 9076 839 2072 -188ATOM875 NH1 ARG 125 5.55137.025 48.866 1.000 38.62ANISOU 875 NH1 ARG 125 3999 2858 7816 -85861 -700ATOM876 NH2 ARG 125 5.85838.382 47.006 1.000 42.11ANISOU 876 NH2 ARG 125 5319 2652 8030 908 1627 -681ATOM877 NGLN 126 6.88429.282 46.557 1.000 15.28ANISOU 877 NGLN 126 1876 1527 2404 -70 13 -60ATOM878 CA GLN 126 7.37627.929 46.853 1.000 15.37ANISOU 878 CA GLN 126 1726 1625 2488 -54 -312 20ATOM879 CGLN 126 7.64927.150 45.578 1.000 14.21ANISOU 879 CGLN 126 1643 1268 2488 -75 -398 71ATOM880 OGLN 126 8.68226.462 45.496 1.000 15.36ANISOU 880 OGLN 126 1531 1554 2753 -37 -316 53ATOM881 CB GLN 126 6.35627.158 47.702 1.000 17.40ANISOU 881 CB GLN 126 2034 1313 3264 158 29343ATOM882 CG GLN 126 6.33627.634 49.150 1.000 26.14ANISOU 882 CG GLN 126 4503 1690 3739 431 1908 -732ATOM883 CD GLN 126 5.20826.998 49.891 1.000 21.95ANISOU 883 CD GLN 126 2957 2670 2713 0 -123 102ATOM884 OE1 GLN 126 4.05127.372 49.730 1.000 42.52ANISOU 884 OE1 GLN 126 2994 5747 7416 -62 -1272 3147ATOM885 NE2 GLN 126 5.52426.003 50.691 1.000 28.32ANISOU 885 NE2GLN 126 286739713922 -184-780 1311ATOM 886 N TYR 127 6.797 27.287 44.5741.000 14.52ANISOU 886 N TYR 127 162914382448 -41 -373 -36ATOM 887 CA TYR 127 7.039 26.554 43.3171.000 13.93ANISOU 887 CA TYR 127 156314552277 -136-234 150ATOM 888 C TYR 127 8.289 27.091 42.6241.000 14.54ANISOU 888 C TYR 127 146113182745 24 -195 190ATOM 889 O TYR 127 9.133 26.345 42.1401.000 14.39ANISOU 889 O TYR 127 161115802277 34 -252 9ATOM 890 CB TYR 127 5.801 26.676 42.4351.000 14.00ANISOU 890 CB TYR 127 151015492258 29 -180 -70ATOM 891 CG TYR 127 5.752 25.795 41.2021.000 12.33ANISOU 891 CG TYR 127 131510372334 -34 -187 45ATOM 892 CD1TYR 127 6.483 24.626 41.0241.000 14.05ANISOU 892 CD1TYR 127 181011582371 7 -84-8ATOM 893 CD2TYR 127 4.837 26.086 40.2061.000 15.71ANISOU 893 CD2TYR 127 193615482484 55 -513 21ATOM 894 CE1TYR 127 6.382 23.829 39.8991.000 13.10ANISOU 894 CE1TYR 127 1450999 2529 -101-227 -62ATOM 895 CE2TYR 127 4.661 25.322 39.0711.000 15.07ANISOU 895 CE2TYR 127 192816202177 158 -342 197ATOM 896 CZ TYR 127 5.440 24.179 38.9341.000 13.71ANISOU 896 CZ TYR 127 161713482245 -146-106 246ATOM 897 OH TYR 127 5.337 23.386 37.8111.000 15.04ANISOU 897 OH TYR 127 168217552279 -87 -6053ATOM 898 N THR 128 8.467 28.412 42.6161.000 14.69ANISOU 898 N THR 128 181313242446 -154-217 268ATOM 899 CA THR 128 9.673 28.984 42.0111.000 14.67ANISOU 899 CA THR 128 186714692238 -98 -32195ATOM 900 C THR 128 10.921 28.552 42.7361.000 14.68ANISOU 900 C THR 128 179413182466 59 -123 -285ATOM 901 O THR 128 11.900 28.166 42.0621.000 15.45ANISOU 901 O THR 128 171514872667 -25915371ATOM 902 CB THR 128 9.572 30.544 42.0691.000 16.02ANISOU 902 CB THR 128 204313482695 -79 59 479ATOM 903 OG1THR 128 8.519 30.849 41.1621.000 19.14ANISOU 903 OG1THR 128 222620383008 195 -23545ATOM 904 CG2THR 128 10.835 31.187 41.5821.000 19.03ANISOU 904 CG2THR 128 210713293793 125 311618ATOM 905 N ALA 129 10.933 28.564 44.0851.000 14.21ANISOU 905 N ALA 129 170812662424 -137-256 -181ATOM 906 CA ALA 129 12.108 28.110 44.8361.000 15.08ANISOU 906 CA ALA 129 167014352624 -118-210 -225ATOM 907 C ALA 129 12.389 26.643 44.5621.000 14.37ANISOU 907 C ALA 129 170612992457 -159-203 157ATOM 908 O ALA 129 13.552 26.238 44.4451.000 14.10ANISOU 908 O ALA 129 175814642137 -5 -244 -148ATOM 909 CB ALA 129 11.887 28.313 46.3131.000 17.08ANISOU 909 CB ALA 129 213218512506 -183-514 -239ATOM 910 N SER 130 11.343 25.819 44.5531.000 14.18ANISOU 910 N SER 130 188412372267 -224-257 173ATOM 911 CA SER 130 11.487 24.375 44.3511.000 15.44ANISOU 911 CA SER 130 184012192807 -115-135 -7ATOM 912 C SER 130 12.072 24.114 42.9651.000 14.45ANISOU 912 C SER 130 134514812665 78 -796 -209ATOM 913 O SER 130 13.037 23.329 42.8071.000 14.43ANISOU 913 O SER 130 132713822773 -74 -246 172ATOM 914 CB SER 130 10.120 23.677 44.6631.000 17.54ANISOU 914 CB SER 130 155512253884 -379-647 126ATOM 915 OG SER 130 9.268 23.888 43.5581.000 27.32ANISOU 915 OG SER 130 232131684893 11 -1207 865ATOM 916N ARG 131 11.555 24.772 41.9091.00014.47ANISOU 916N ARG 131 1421 1448 2628 161 -384 -166ATOM 917CAARG 131 12.163 24.598 40.5921.00014.91ANISOU 917CAARG 131 1689 1452 2525 -4 -526 -341ATOM 918C ARG 131 13.605 25.079 40.5661.00014.05ANISOU 918C ARG 131 1772 1435 2132 -72 -381 -173ATOM 919O ARG 131 14.448 24.438 39.9121.00015.14ANISOU 919O ARG 131 1829 1658 2267 -109 -170 -230ATOM 920CBARG 131 11.349 25.316 39.5141.00015.77ANISOU 920CBARG 131 1720 1613 2660 -54 -493 -94ATOM 921CGARG 131 9.970 24.737 39.2511.00016.08ANISOU 921CGARG 131 1703 1695 2711 -13 -647 -141ATOM 922CDARG 131 9.326 25.390 38.0171.00026.56ANISOU 922CDARG 131 3589 2689 3813 -1037-2156 745ATOM 923NEARG 131 9.327 26.831 37.9181.00025.91ANISOU 923NEARG 131 2856 2814 4174 -979 -1682 1413ATOM 924CZARG 131 8.472 27.716 38.4131.00031.86ANISOU 924CZARG 131 3546 2861 5697 -254 -1094 2201ATOM 925NH1 ARG 131 7.467 27.244 39.1381.00031.34ANISOU 925NH1 ARG 131 5127 3636 3144 -1474-458 -115ATOM 926NH2 ARG 131 8.633 29.032 38.2351.00040.12ANISOU 926NH2 ARG 131 3500 2831 8912 -582 -1620 1802ATOM 927N ALA 132 13.893 26.186 41.2361.00013.42ANISOU 927N ALA 132 1683 1385 2033 -85 -652 -24ATOM 928CAALA 132 15.246 26.751 41.1281.00013.38ANISOU 928CAALA 132 1617 1443 2022 -16 -499 -79ATOM 929C ALA 132 16.225 25.808 41.8371.00013.37ANISOU 929C ALA 132 1398 1365 2316 -93 -253 154ATOM 930O ALA 132 17.306 25.586 41.3281.00014.43ANISOU 930O ALA 132 1459 1772 2251 -91 -240 106ATOM 931CBALA 132 15.275 28.084 41.8591.00016.52ANISOU 931CBALA 132 2019 1243 3014 -199 -366 -236ATOM 932N VAL 133 15.893 25.248 42.9961.00013.62ANISOU 932N VAL 133 1522 1515 2139 -63 -362 86ATOM 933CAVAL 133 16.839 24.363 43.6891.00014.86ANISOU 933CAVAL 133 1902 1566 2179 120 -491 -27ATOM 934C VAL 133 16.923 23.073 42.8901.00015.04ANISOU 934C VAL 133 1390 1633 2690 -9 -220 -218ATOM 935O VAL 133 18.036 22.538 42.7731.00015.49ANISOU 935O VAL 133 1442 1814 2630 63 -193 -99ATOM 936CBVAL 133 16.545 24.170 45.1871.00014.61ANISOU 936CBVAL 133 1528 1789 2234 -45 -391 210ATOM 937CG1 VAL 133 15.362 23.267 45.4531.00016.78ANISOU 937CG1 VAL 133 1544 2123 2708 -249 -437 -81ATOM 938CG2 VAL 133 17.766 23.650 45.9501.00016.51ANISOU 938CG2 VAL 133 1769 1942 2561 -61 -831 64ATOM 939N ALA 134 15.840 22.583 42.2701.00013.73ANISOU 939N ALA 134 1605 1451 2160 -75 -397 185ATOM 940CAALA 134 15.951 21.369 41.4511.00014.21ANISOU 940CAALA 134 1505 1796 2100 116 -570 -33ATOM 941C ALA 134 16.838 21.618 40.2461.00015.07ANISOU 941C ALA 134 1766 1511 2450 43 -292 17ATOM 942O ALA 134 17.600 20.750 39.8001.00014.36ANISOU 942O ALA 134 1555 1567 2333 -60 -286 52ATOM 943CBALA 134 14.535 20.925 41.0321.00016.97ANISOU 943CBALA 134 1472 1943 3031 12 -470 -299ATOM 944N ARG 135 16.752 22.808 39.6311.00015.48ANISOU 944N ARG 135 1848 1600 2433 14 -341 -2ATOM 945CAARG 135 17.618 23.153 38.5081.00016.07ANISOU 945CAARG 135 2139 1230 2735 -138 -189 35ATOM 946C ARG 135 19.082 23.057 38.9551.00015.70ANISOU 946 C ARG 135 205913702535 -134 27 121ATOM 947 O ARG 135 19.928 22.604 38.1761.00018.07ANISOU 947 O ARG 135 231720142534 108 256276ATOM 948 CBARG 135 17.277 24.586 38.0961.00021.96ANISOU 948 CBARG 135 393616402767 -4 -1480 614ATOM 949 CGARG 135 17.571 24.989 36.6891.00027.53ANISOU 949 CGARG 135 511224822866 816 -610 595ATOM 950 CDARG 135 16.930 26.332 36.3931.00023.27ANISOU 950 CDARG 135 354824282865 148 61 1371ATOM 951 NEARG 135 15.551 26.309 35.9281.00022.68ANISOU 951 NEARG 135 348815753556 -116 167297ATOM 952 CZARG 135 14.520 26.858 36.5621.00025.90ANISOU 952 CZARG 135 380121653874 921 -506 -179ATOM 953 NH1 ARG 135 14.708 27.515 37.7021.00023.50ANISOU 953 NH1 ARG 135 358223782969 94 137532ATOM 954 NH2 ARG 135 13.287 26.758 36.0351.00024.30ANISOU 954 NH2 ARG 135 352024413272 -101 72 582ATOM 955 N GLU 136 19.403 23.533 40.1491.00015.76ANISOU 955 N GLU 136 189716962396 -178 17 318ATOM 956 CAGLU 136 20.752 23.431 40.6941.00015.16ANISOU 956 CAGLU 136 168717702302 -97 279140ATOM 957 C GLU 136 21.186 22.001 40.9781.00016.74ANISOU 957 C GLU 136 153517043122 -148 -172 -72ATOM 958 O GLU 136 22.350 21.637 40.7011.00017.42ANISOU 958 O GLU 136 171019082999 730 92ATOM 959 CBGLU 136 20.957 24.284 41.9621.00016.64ANISOU 959 CBGLU 136 204817852487 53 11 -16ATOM 960 CGGLU 136 20.762 25.772 41.7181.00017.80ANISOU 960 CGGLU 136 203617143014 -286 -169 110ATOM 961 CDGLU 136 21.534 26.269 40.5131.00020.92ANISOU 961 CDGLU 136 217422733503 -343 70 469ATOM 962 OE1 GLU 136 22.742 25.987 40.4541.00024.97ANISOU 962 OE1 GLU 136 211624344938 -494 531219ATOM 963 OE2 GLU 136 21.022 27.037 39.6721.00024.77ANISOU 963 OE2 GLU 136 297526183817 -708 -133 1029ATOM 964 N VAL 137 20.262 21.172 41.4501.00015.34ANISOU 964 N VAL 137 168116962453 -108 -287 113ATOM 965 CAVAL 137 20.568 19.750 41.6471.00015.92ANISOU 965 CAVAL 137 175518022493 83 -4 210ATOM 966 C VAL 137 20.926 19.086 40.3261.00015.86ANISOU 966 C VAL 137 160418692555 -38 -3566ATOM 967 O VAL 137 21.905 18.308 40.1741.00016.70ANISOU 967 O VAL 137 161721182609 72 -151 -90ATOM 968 CBVAL 137 19.358 18.990 42.2831.00015.35ANISOU 968 CBVAL 137 172916632440 8-295ATOM 969 CG1 VAL 137 19.607 17.478 42.1761.00016.93ANISOU 969 CG1 VAL 137 152116893223 160 -345 96ATOM 970 CG2 VAL 137 19.144 19.420 43.7241.00015.43ANISOU 970 CG2 VAL 137 152920902245 -53 -277 185ATOM 971 N LEU 138 20.149 19.407 39.2841.00015.52ANISOU 971 N LEU 138 162517352535 -105 -61109ATOM 972 CALEU 138 20.378 18.881 37.9361.00015.74ANISOU 972 CALEU 138 157618622543 -71 15 51ATOM 973 C LEU 138 21.721 19.396 37.4061.00017.42ANISOU 973 C LEU 138 158821192912 -87 162-45ATOM 974 O LEU 138 22.503 18.609 36.8461.00019.13ANISOU 974 O LEU 138 187824062985 186 31762ATOM 975 CBLEU 138 19.211 19.248 36.9961.00014.70ANISOU 975 CBLEU 138 159216422349 -50 141190ATOM 976 CGLEU 138 17.883 18.541 37.3751.00014.38ANISOU 976 CGLEU 138 165714092399 -44 -4 288ATOM977 CD1 LEU 138 16.774 19.122 36.491 1.000 16.13ANISOU 977 CD1 LEU 138 1743 18482539 128 -218 168ATOM978 CD2 LEU 138 17.975 17.027 37.156 1.000 17.48ANISOU 978 CD2 LEU 138 2185 14353021 -107-480 287ATOM979 N ARG 139 21.963 20.708 37.548 1.000 17.44ANISOU 979 N ARG 139 1797 21572674 -319238192ATOM980 CAARG 139 23.189 21.319 36.996 1.000 19.06ANISOU 980 CAARG 139 2043 24622735 -366482376ATOM981 C ARG 139 24.419 20.734 37.685 1.000 19.72ANISOU 981 C ARG 139 1797 26003097 -518482376ATOM982 O ARG 139 25.461 20.432 37.094 1.000 20.70ANISOU 982 O ARG 139 2046 24693350 -288607195ATOM983 CBARG 139 23.152 22.850 37.101 1.000 24.54ANISOU 983 CBARG 139 2525 24034396 -402951690ATOM984 CGARG 139 23.886 23.665 36.073 1.000 36.05ANISOU 984 CGARG 139 6517 29674212 -2176 1609 140ATOM985 CDARG 139 23.852 25.148 36.443 1.000 44.95ANISOU 985 CDARG 139 7459 19027716 -242-1324 1930ATOM986 NEARG 139 22.525 25.727 36.547 1.000 43.27ANISOU 986 NEARG 139 6637 38465959 -828-2173 -698ATOM987 CZARG 139 21.821 26.330 35.605 1.000 41.34ANISOU 987 CZARG 139 5939 41025666 497 6451140ATOM988 NH1 ARG 139 22.308 26.436 34.376 1.000 44.01ANISOU 988 NH1 ARG 139 6564 41466011 550 1393 336ATOM989 NH2 ARG 139 20.614 26.837 35.833 1.000 45.75ANISOU 989 NH2 ARG 139 6162 46186602 537 1938 2405ATOM990 N ALA 140 24.357 20.566 39.009 1.000 18.77ANISOU 990 N ALA 140 1742 23873003 -25514569ATOM991 CAALA 140 25.532 20.169 39.773 1.000 19.53ANISOU 991 CAALA 140 1583 26413197 -28 38 -668ATOM992 C ALA 140 25.932 18.732 39.490 1.000 18.96ANISOU 992 C ALA 140 2018 23422843 -67 76 -103ATOM993 O ALA 140 27.109 18.335 39.626 1.000 21.36ANISOU 993 O ALA 140 1900 24363778 -2 472-80ATOM994 CBALA 140 25.273 20.345 41.275 1.000 19.74ANISOU 994 CBALA 140 1824 25923084 35 0 -360ATOM995 N THR 141 24.958 17.943 39.062 1.000 20.32ANISOU 995 N THR 141 2014 22093498 -115305-138ATOM996 CATHR 141 25.151 16.530 38.717 1.000 17.15ANISOU 996 CATHR 141 1870 20392609 61 51 218ATOM997 C THR 141 25.269 16.278 37.208 1.000 17.44ANISOU 997 C THR 141 1492 24432693 21 278199ATOM998 O THR 141 25.343 15.106 36.792 1.000 19.24ANISOU 998 O THR 141 1871 26232814 63 579-63ATOM999 CBTHR 141 24.048 15.629 39.290 1.000 16.79ANISOU 999 CBTHR 141 1708 22612410 83 16431ATOM1000OG1 THR 141 22.788 16.012 38.710 1.000 17.18ANISOU 1000OG1 THR 141 1894 22352399 -101-53518ATOM1001CG2 THR 141 23.982 15.734 40.807 1.000 17.83ANISOU 1001CG2 THR 141 1521 28782377 164 -4320ATOM1002N GLY 142 25.361 17.301 36.381 1.000 19.69ANISOU 1002N GLY 142 2091 27892603 -708302297ATOM1003CAGLY 142 25.517 17.123 34.923 1.000 19.08ANISOU 1003CAGLY 142 1878 28192551 128 -163 255ATOM1004C GLY 142 24.284 16.441 34.313 1.000 18.75ANISOU 1004C GLY 142 1972 24102744 0 252-117ATOM1005O GLY 142 24.443 15.755 33.315 1.000 22.41ANISOU 1005O GLY 142 2432 26813403 -161571-680ATOM1006N THR 143 23.093 16.650 34.854 1.000 17.28ANISOU 1006N THR 143 1895 20022667 67 300244ATOM1007CATHR 143 21.909 15.932 34.393 1.000 16.88ANISOU 1007 CA THR 143 1953 2006 2456 164 33266ATOM 1008 C THR 143 20.998 16.660 33.4321.000 17.02ANISOU 1008 C THR 143 2149 1795 2521 82196117ATOM 1009 O THR 143 20.457 17.713 33.7641.000 20.30ANISOU 1009 O THR 143 2795 1815 3103 344 12 -28ATOM 1010 CB THR 143 21.085 15.490 35.6231.000 16.40ANISOU 1010 CB THR 143 1755 2329 2148 -37 95 -44ATOM 1011 OG1 THR 143 21.922 14.692 36.4791.000 17.82ANISOU 1011 OG1 THR 143 2009 2075 2688 -109 39 337ATOM 1012 CG2 THR 143 19.887 14.621 35.2701.000 19.51ANISOU 1012 CG2 THR 143 1957 2290 3167 -192 -94100ATOM 1013 N GLU 144 20.742 16.070 32.2481.000 18.79ANISOU 1013 N GLU 144 2138 2203 2800 4712 -121ATOM 1014 CA GLU 144 19.729 16.573 31.3341.000 20.13ANISOU 1014 CA GLU 144 2202 2696 2750 -292 -41316ATOM 1015 C GLU 144 18.637 15.506 31.2541.000 19.18ANISOU 1015 C GLU 144 2255 2614 2418 -292 230-131ATOM 1016 O GLU 144 18.827 14.438 30.6651.000 21.46ANISOU 1016 O GLU 144 2268 2442 3446 19649-88ATOM 1017 CB AGLU 144 20.250 17.061 30.0060.753 29.50ANISOU 1017 CB AGLU 144 3376 4266 3566 -855 2061501ATOM 1018 CG AGLU 144 20.195 18.567 29.7410.753 36.54ANISOU 1018 CG AGLU 144 6059 3913 3913 -1728 1769 795ATOM 1019 CD AGLU 144 21.242 19.411 30.4260.753 33.13ANISOU 1019 CD AGLU 144 4189 3432 4966 104 744884ATOM 1020 OE1AGLU 144 21.079 19.690 31.6410.753 51.91ANISOU 1020 OE1AGLU 144 3684 11101 4940 -868 -202 -590ATOM 1021 OE2AGLU 144 22.207 19.910 29.8070.753 50.79ANISOU 1021 OE2AGLU 144 7949 3695 7653 -3071 3099 -1249ATOM 1022 CB BGLU 144 20.372 16.724 29.9510.247 18.36ANISOU 1022 CB BGLU 144 868 3091 3016 334 16 262ATOM 1023 CG BGLU 144 21.214 17.988 29.7790.247 23.54ANISOU 1023 CG BGLU 144 1301 3586 4056 -38 595558ATOM 1024 CD BGLU 144 21.150 18.468 28.3360.247 33.24ANISOU 1024 CD BGLU 144 3589 3975 5064 438 -202031ATOM 1025 OE1BGLU 144 20.417 17.818 27.5570.247 28.68ANISOU 1025 OE1BGLU 144 3222 4813 2861 389 1729 1280ATOM 1026 OE2BGLU 144 21.814 19.464 27.9900.247 35.35ANISOU 1026 OE2BGLU 144 3176 5148 5108 351752 1516ATOM 1027 N PRO 145 17.508 15.724 31.9111.000 17.11ANISOU 1027 N PRO 145 2132 1825 2543 6862 158ATOM 1028 CA PRO 145 16.396 14.781 31.8461.000 17.41ANISOU 1028 CA PRO 145 2290 1942 2384 -73 40012ATOM 1029 C PRO 145 15.966 14.546 30.4061.000 17.94ANISOU 1029 C PRO 145 2386 1955 2475 -116 292-104ATOM 1030 O PRO 145 16.068 15.439 29.5571.000 18.26ANISOU 1030 O PRO 145 2271 2196 2472 -272 17045ATOM 1031 CB PRO 145 15.250 15.493 32.5941.000 17.07ANISOU 1031 CB PRO 145 2181 1771 2534 35133-143ATOM 1032 CG PRO 145 15.950 16.504 33.4641.000 17.11ANISOU 1032 CG PRO 145 2341 1841 2319 23-49-24ATOM 1033 CD PRO 145 17.131 16.977 32.6491.000 17.54ANISOU 1033 CD PRO 145 2178 1601 2884 178 -88303ATOM 1034 N ASP 146 15.490 13.346 30.1041.000 18.15ANISOU 1034 N ASP 146 2140 1965 2790 -60 321-152ATOM 1035 CA ASP 146 14.909 13.121 28.7751.000 18.43ANISOU 1035 CA ASP 146 2487 1664 2853 -329 310-156ATOM 1036 C ASP 146 13.809 14.154 28.5661.000 18.07ANISOU 1036 C ASP 146 2824 1979 2064 -31 208-309ATOM 1037 O ASP 146 12.959 14.333 29.4221.000 18.29ARISOU 1037 O ASP 146 2491 2173 2287 -168 203-230ATOM 1038 CB ASP 146 14.221 11.753 28.717 1.000 23.50ANISOU 1038 CB ASP 146 3489 1671 3769 -653908-665ATOM 1039 CG ASP 146 13.636 11.508 27.334 1.000 34.15ANISOU 1039 CG ASP 146 4070 4205 4700 -1004 361-2386ATOM 1040 OD1 ASP 146 12.393 11.521 27.138 1.000 44.73ANISOU 1040 OD1 ASP 146 3971 9175 3849 -2156 683378ATOM 1041 OD2 ASP 146 14.421 11.229 26.397 1.000 44.78ANISOU 1041 OD2 ASP 146 4342 8626 4046 -813289-2326ATOM 1042 N GLY 147 13.901 14.854 27.450 1.000 19.28ANISOU 1042 N GLY 147 2622 2331 2374 -635-72113ATOM 1043 CA GLY 147 12.916 15.878 27.171 1.000 18.58ANISOU 1043 CA GLY 147 2463 2607 1991 -550-234 -36ATOM 1044 C GLY 147 13.355 17.262 27.590 1.000 18.25ANISOU 1044 C GLY 147 2511 2432 1993 -335-138 64ATOM 1045 O GLY 147 12.586 18.183 27.289 1.000 20.74ANISOU 1045 O GLY 147 2469 2739 2673 -182-144 205ATOM 1046 N GLY 148 14.494 17.357 28.286 1.000 17.38ANISOU 1046 N GLY 148 2237 2174 2191 -462-42-90ATOM 1047 CA GLY 148 15.027 18.658 28.672 1.000 16.72ANISOU 1047 CA GLY 148 2308 1789 2255 39 -82-77ATOM 1048 C GLY 148 14.653 19.076 30.085 1.000 13.94ANISOU 1048 C GLY 148 1517 1645 2135 77 -201 117ATOM 1049 O GLY 148 13.637 18.634 30.694 1.000 16.29ANISOU 1049 O GLY 148 1839 1863 2487 -151-77285ATOM 1050 N VAL 149 15.431 20.003 30.641 1.000 14.93ANISOU 1050 N VAL 149 1624 1780 2269 1 -193 -14ATOM 1051 CA VAL 149 15.275 20.509 32.017 1.000 14.16ANISOU 1051 CA VAL 149 1647 1511 2222 92 -195 86ATOM 1052 C VAL 149 13.958 21.218 32.235 1.000 14.37ANISOU 1052 C VAL 149 1735 1044 2682 -39 83 188ATOM 1053 O VAL 149 13.203 20.970 33.163 1.000 14.63ANISOU 1053 O VAL 149 1653 1517 2390 -160-40107ATOM 1054 CB VAL 149 16.439 21.410 32.417 1.000 14.02ANISOU 1054 CB VAL 149 1745 1530 2052 -112-57270ATOM 1055 CG1 VAL 149 16.228 22.101 33.752 1.000 16.48ANISOU 1055 CG1 VAL 149 2360 1709 2193 -153-305 87ATOM 1056 CG2 VAL 149 17.733 20.614 32.482 1.000 17.85ANISOU 1056 CG2 VAL 149 1618 1937 3226 -59 -52441ATOM 1057 N GLU 150 13.634 22.199 31.371 1.000 15.26ANISOU 1057 N GLU 150 1759 1328 2711 186 36 267ATOM 1058 CA GLU 150 12.471 23.028 31.687 1.000 14.91ANISOU 1058 CA GLU 150 1591 1434 2640 93 13 415ATOM 1059 C GLU 150 11.182 22.237 31.553 1.000 16.66ANISOU 1059 C GLU 150 1680 1980 2670 -197113199ATOM 1060 O GLU 150 10.259 22.408 32.379 1.000 15.89ANISOU 1060 O GLU 150 1697 1761 2578 29 79 580ATOM 1061 CB GLU 150 12.531 24.305 30.874 1.000 17.07ANISOU 1061 CB GLU 150 1925 1337 3223 254 189513ATOM 1062 CG GLU 150 13.761 25.167 31.220 1.000 19.00ANISOU 1062 CG GLU 150 2483 1212 3523 -65 -95465ATOM 1063 CD GLU 150 13.810 25.624 32.658 1.000 20.32ANISOU 1063 CD GLU 150 2444 1746 3532 -130-24454ATOM 1064 OE1 GLU 150 12.781 25.749 33.377 1.000 20.88ANISOU 1064 OE1 GLU 150 2558 1728 3648 29 58 396ATOM 1065 OE2 GLU 150 14.913 25.946 33.161 1.000 21.77AMISOU 1065 OE2 GLU 150 2549 2030 3693 -165-202 273ATOM 1066 N ALA 151 11.050 21.288 30.603 1.000 14.98ANISOU 1066 N ALA 151 1649 1710 2334 37 -307 551ATOM 1067 CA ALA 151 9.83420.475 30.543 1.000 15.79ANISOU 1067 CA ALA 151 1820 2045 2136 -173-198 408ATOM 1068 C ALA 151 9.74819.531 31.724 1.000 15.38ANISOU 1068 CALA 151 1674 19532216 165 161442ATOM1069 OALA 151 8.64219.186 32.1841.00016.51ANISOU 1069 OALA 151 1778 18522643 -152 110330ATOM1070 CB ALA 151 9.82319.663 29.2361.00018.05ANISOU 1070 CB ALA 151 1910 28112139 -275 -316 166ATOM1071 NPHE 152 10.893 19.135 32.3061.00014.25ANISOU 1071 NPHE 152 1858 11322423 10 -107 263ATOM1072 CA PHE 152 10.893 18.285 33.4931.00013.42ANISOU 1072 CA PHE 152 1457 12912353 -102 -34304ATOM1073 CPHE 152 10.406 19.056 34.6951.00013.93ANISOU 1073 CPHE 152 1481 14002412 -43 -165 196ATOM1074 OPHE 152 9.67918.495 35.5581.00014.50ANISOU 1074 OPHE 152 1590 14822438 -85 25 26ATOM1075 CB PHE 152 12.309 17.744 33.7281.00013.95ANISOU 1075 CB PHE 152 1504 15472248 -29 111463ATOM1076 CG PHE 152 12.475 16.966 35.0111.00014.04ANISOU 1076 CG PHE 152 1747 13862200 88 -58247ATOM1077 CD1 PHE 152 12.032 15.653 35.0761.00013.90ANISOU 1077 CD1 PHE 152 1906 13062069 165 -36281ATOM1078 CD2 PHE 152 13.094 17.499 36.1271.00015.67ANISOU 1078 CD2 PHE 152 1927 17702259 -155 -115 233ATOM1079 CE1 PHE 152 12.213 14.949 36.2631.00014.06ANISOU 1079 CE1 PHE 152 1669 15072165 182 -282 347ATOM1080 CE2 PHE 152 13.323 16.799 37.2761.00014.83ANISOU 1080 CE2 PHE 152 1724 16712240 35 -112 165ATOM1081 CZ PHE 152 12.861 15.522 37.3611.00014.86ANISOU 1081 CZ PHE 152 1994 17341916 -162 99 113ATOM1082 NLEU 153 10.789 20.324 34.7891.00015.25ANISOU 1082 NLEU 153 1742 13552696 58 110154ATOM1083 CA LEU 153 10.454 21.151 35.9391.00014.65ANISOU 1083 CA LEU 153 1783 14292354 -66 16 203ATOM1084 CLEU 153 9.08221.791 35.8771.00014.47ANISOU 1084 CLEU 153 1732 14022362 -80 76 11ATOM1085 OLEU 153 8.58122.216 36.9531.00015.82ANISOU 1085 OLEU 153 1940 14542616 -313 312-157ATOM1086 CB LEU 153 11.537 22.224 36.1651.00016.53ANISOU 1086 CB LEU 153 1626 14513205 -23 269-83ATOM1087 CG LEU 153 12.914 21.685 36.5141.00015.90ANISOU 1087 CG LEU 153 1893 20132135 -33 -186 -36ATOM1088 CD1 LEU 153 13.922 22.829 36.6141.00018.41ANISOU 1088 CD1 LEU 153 1732 24732791 -156 80 -876ATOM1089 CD2 LEU 153 12.863 20.883 37.7941.00021.76ANISOU 1089 CD2 LEU 153 3083 31822005 365 261193ATOM1090 NASP 154 8.47321.866 34.7081.00014.41ANISOU 1090 NASP 154 1768 11812525 -25 -8 293ATOM1091 CA ASP 154 7.09222.373 34.5531.00015.90ANISOU 1091 CA ASP 154 1665 16152760 -195 27 769ATOM1092 CASP 154 6.21621.161 34.8141.00014.66ANISOU 1092 CASP 154 1859 13042409 -92 143515ATOM1093 OASP 154 5.99520.368 33.8891.00017.30ANISOU 1093 OASP 154 2561 14552557 -29 314234ATOM1094 CB ASP 154 6.92322.909 33.1251.00018.59ANISOU 1094 CB ASP 154 1905 20773081 124 2691317ATOM1095 CG ASP 154 5.46123.157 32.7681.00019.87ANISOU 1095 CG ASP 154 2029 25312990 226 1291436ATOM1096 OD1 ASP 154 4.56123.253 33.6391.00019.68ANISOU 1096 OD1 ASP 154 1949 22093318 92 221496ATOM1097 OD2 ASP 154 5.20723.189 31.5541.00023.73ANISOU 1097 OD2 ASP 154 2512 34753029 246 -137 653ATOM1098 NCYS 155 5.83120.904 36.0701.00014.25ANISOU 1098 NCYS 155 1708 13652342 -101 -62546ATOM 1099 CA CYS 155 5.418 19.569 36.4681.00013.45ANISOU 1099 CA CYS 155 160813462158 -191 4 -458ATOM 1100 C CYS 155 4.157 19.574 37.3021.00012.49ANISOU 1100 C CYS 155 164413311772 -200 -148 62ATOM 1101 O CYS 155 3.224 20.303 36.9411.00014.55ANISOU 1101 O CYS 155 163314922402 -122 -111 442ATOM 1102 CB CYS 155 6.664 18.872 37.0981.00014.37ANISOU 1102 CB CYS 155 190713662186 122 -137 211ATOM 1103 SG CYS 155 7.265 19.595 38.6411.00014.99ANISOU 1103 SG CYS 155 156118212315 -74 -98182ATOM 1104 N GLU 156 4.060 18.706 38.3161.00012.89ANISOU 1104 N GLU 156 157513791945 -130 29 194ATOM 1105 CA GLU 156 2.788 18.447 39.0291.00012.98ANISOU 1105 CA GLU 156 150813112114 -210 21 140ATOM 1106 C GLU 156 2.987 18.676 40.5101.00012.34ANISOU 1106 C GLU 156 141411982078 102 24 204ATOM 1107 O GLU 156 2.828 17.757 41.2891.00014.89ANISOU 1107 O GLU 156 187514252359 -15 -54442ATOM 1108 CB GLU 156 2.278 17.047 38.6781.00014.48ANISOU 1108 CB GLU 156 196813232213 -279 12087ATOM 1109 CG GLU 156 1.855 17.038 37.2271.00014.86ANISOU 1109 CG GLU 156 189415262227 -120 95 -152ATOM 1110 CD GLU 156 0.523 17.687 36.9321.00017.10ANISOU 1110 CD GLU 156 209119762431 44 -4 144ATOM 1111 OE1 GLU 156 -0.204 17.967 37.8861.00017.98ANISOU 1111 OE1 GLU 156 181121552866 -35 10 -355ATOM 1112 OE2 GLU 156 0.214 17.990 35.7591.00020.99ANISOU 1112 OE2 GLU 156 285424192704 -386 -516 562ATOM 1113 N PRO 157 3.292 19.893 40.9581.00012.09ANISOU 1113 N PRO 157 131413471934 12 -48249ATOM 1114 CA PRO 157 3.576 20.121 42.3911.00013.28ANISOU 1114 CA PRO 157 142516961924 -68 117147ATOM 1115 C PRO 157 2.330 19.996 43.2481.00012.87ANISOU 1115 C PRO 157 123617371916 -214 -47124ATOM 1116 O PRO 157 1.192 20.190 42.7441.00013.73ANISOU 1116 O PRO 157 128617172214 -190 -17143ATOM 1117 CB PRO 157 4.061 21.580 42.4071.00013.94ANISOU 1117 CB PRO 157 151817292047 -289 -166 247ATOM 1118 CG PRO 157 3.363 22.184 41.2261.00013.06ANISOU 1118 CG PRO 157 155815181887 -32 -158 -88ATOM 1119 CD PRO 157 3.494 21.128 40.1671.00012.03ANISOU 1119 CD PRO 157 152110811968 -2 -7 121ATOM 1120 N LEU 158 2.542 19.738 44.5261.00013.02ANISOU 1120 N LEU 158 155414931899 -124 14873ATOM 1121 CA LEU 158 1.438 19.699 45.4961.00012.72ANISOU 1121 CA LEU 158 146515521815 -126 -1436ATOM 1122 C LEU 158 1.927 20.389 46.7721.00012.90ANISOU 1122 C LEU 158 123017151957 -27 -29-80ATOM 1123 O LEU 158 2.975 19.977 47.2891.00014.06ANISOU 1123 O LEU 158 137416662304 59 -257 -236ATOM 1124 CB LEU 158 1.046 18.244 45.8151.00013.58ANISOU 1124 CB LEU 158 167315901896 -213 57 171ATOM 1125 CG LEU 158 0.044 18.030 46.9451.00014.84ANISOU 1125 CG LEU 158 147117742396 -16 262242ATOM 1126 CD1 LEU 158 -1.333 18.635 46.6711.00016.96ANISOU 1126 CD1 LEU 158 148521962764 5-148 -401ATOM 1127 CD2 LEU 158 -0.142 16.539 47.1611.00014.98ANISOU 1127 CD2 LEU 158 197618201897 -390 17179ATOM 1128 N LEU 159 1.139 21.306 47.2831.00013.44ANISOU 1128 N LEU 159 150914342165 43 -87-119ATOM 1129 CA LEU 159 1.443 21.963 48.5711.00013.39ANISOU 1129 CALEU 159 143815552095 -36 -80-91ATOM 1130 C LEU 159 0.419 21.494 49.6021.00014.49ANISOU 1130 C LEU 159 133620342135 -152 -208 -38ATOM 1131 O LEU 159 -0.790 21.596 49.4191.00015.09ANISOU 1131 O LEU 159 141419992319 90 -131 90ATOM 1132 CBLEU 159 1.390 23.466 48.3941.00015.28ANISOU 1132 CBLEU 159 172014472639 55 -325 -197ATOM 1133 CGLEU 159 1.484 24.320 49.6691.00017.11ANISOU 1133 CGLEU 159 214616892665 363 -332 -343ATOM 1134 CD1 LEU 159 2.775 24.114 50.4531.00018.70ANISOU 1134 CD1 LEU 159 227617593070 379 -687 -540ATOM 1135 CD2 LEU 159 1.312 25.801 49.2911.00021.00ANISOU 1135 CD2 LEU 159 291815353526 439 -692 -382ATOM 1136 N ARG 160 0.916 21.107 50.7741.00014.37ANISOU 1136 N ARG 160 168817092063 -101 -186 47ATOM 1137 CAARG 160 0.055 20.747 51.9011.00015.61ANISOU 1137 CAARG 160 172619902217 -64 90 -118ATOM 1138 C ARG 160 0.480 21.501 53.1551.00015.40ANISOU 1138 C ARG 160 155721582135 -34 -46-38ATOM 1139 O ARG 160 1.639 21.401 53.5761.00016.32ANISOU 1139 O ARG 160 152825082164 63 41 -104ATOM 1140 CBARG 160 0.048 19.263 52.2271.00016.13ANISOU 1140 CBARG 160 213420841912 -127 -30129ATOM 1141 CGARG 160 -0.594 18.410 51.1551.00017.17ANISOU 1141 CGARG 160 196319342628 -140 -212 -60ATOM 1142 CDARG 160 -0.672 16.959 51.6271.00018.16ANISOU 1142 CDARG 160 276719652166 125 -330 -35ATOM 1143 NEARG 160 -1.382 16.102 50.6821.00018．11ANISOU 1143 NEARG 160 240817752699 -56 -30820ATOM 1144 CZARG 160 -1.221 14.789 50.5811.00016.76ANISOU 1144 CZARG 160 219117482428 -97 55 174ATOM 1145 NH1 ARG 160 -0.326 14.192 51.3741.00020.55ANISOU 1145 NH1 ARG 160 230620123491 -26 -457 305ATOM 1146 NH2 ARG 160 -1.908 14.095 49.6891.00019.23ANISOU 1146 NH2 ARG 160 250220312774 181 -147 -338ATOM 1147 N PHE 161 -0.469 22.257 53.7551.00015.36ANISOU 1147 N PHE 161 160421202111 -37 -63-128ATOM 1148 CAPHE 161 -0.209 22.975 54.9991.00016.25ANISOU 1148 CAPHE 161 217317742227 -71 -187 -89ATOM 1149 C PHE 161 -1.030 22.236 56.0691.00016.98ANISOU 1149 C PHE 161 198024322041 -217 -161 -162ATOM 1150 O PHE 161 -2.248 22.113 55.9481.00020.38ANISOU 1150 O PHE 161 198132912473 -190 -191 -72ATOM 1151 CBPHE 161 -0.683 24.431 54.8621.00019.76ANISOU 1151 CBPHE 161 206519033540 167 355-198ATOM 1152 CGPHE 161 -0.379 25.259 56.1091.00023.61ANISOU 1152 CGPHE 161 302619054041 836 -59-591ATOM 1153 CD1 PHE 161 -1.194 25.304 57.2281.00028.25ANISOU 1153 CD1 PHE 161 399224744268 1077 369-1253ATOM 1154 CD2 PHE 161 0.807 25.978 56.1411.00026.62ANISOU 1154 CD2 PHE 161 401524833616 -130 -927 -106ATOM 1155 CE1 PHE 161 -0.850 25.992 58.3831.00035.29ANISOU 1155 CE1 PHE 161 687320974437 1538 -135 -1399ATOM 1156 CE2 PHE 161 1.153 26.723 57.2581.00033.63ANISOU 1156 CE2 PHE 161 464332404894 1263 -2085 -1268ATOM 1157 CZPHE 161 0.320 26.726 58.3631.00036.44ANISOU 1157 CZPHE 161 607142823493 1455 -2477 -1044ATOM 1158 N ARG 162 -0.358 21.767 57.1301.00017.59ANISOU 1158 N ARG 162 209524872103 -118 -135 -69ATOM 1159 CAARG 162 -1.072 21.078 58.1991.00018.27ANISOU 1159 CAARG 162 276924141758 6178-378ATOM1160 C ARG 162 -0.880 21.758 59.5531.000 20.16ANISOU 1160 C ARG 162 2110 3341 2210 -36 41 -960ATOM1161 O ARG 162 0.217 22.160 59.8931.000 19.61ANISOU 1161 O ARG 162 2257 2993 2201 -194-73-359ATOM1162 CBARG 162 -0.580 19.640 58.3561.000 20.81ANISOU 1162 CBARG 162 2958 2275 2675 -1296 -169ATOM1163 CGARG 162 -0.843 18.724 57.1661.000 19.90ANISOU 1163 CGARG 162 3044 2073 2443 -112254-38ATOM1164 CDARG 162 -0.182 17.383 57.3931.000 28.02ANISOU 1164 CDARG 162 5599 2038 3010 381 -14114ATOM1165 NEARG 162 -0.369 16.420 56.3261.000 27.74ANISOU 1165 NEARG 162 4151 2294 4097 555 -687 -434ATOM1166 CZARG 162 -1.278 15.445 56.3701.000 31.11ANISOU 1166 CZARG 162 2560 3729 5531 470 -350 -1152ATOM1167 NH1 ARG 162 -2.092 15.324 57.4031.000 42.97ANISOU 1167 NH1 ARG 162 3475 5906 6946 -5791019 -2492ATOM1168 NH2 ARG 162 -1.329 14.603 55.3531.000 29.64ANISOU 1168 NH2 ARG 162 3066 2738 5458 120 -143 -708ATOM1169 N TYR 163 -1.956 21.780 60.3111.000 19.52ANISOU 1169 N TYR 163 2394 2901 2120 147 263-763ATOM1170 CATYR 163 -1.943 22.102 61.7321.000 22.74ANISOU 1170 CATYR 163 3312 3107 2219 369 302-878ATOM1171 C TYR 163 -2.037 20.800 62.5361.000 24.20ANISOU 1171 C TYR 163 2802 3901 2492 -222253-189ATOM1172 O TYR 163 -2.992 20.049 62.2741.000 28.02ANISOU 1172 O TYR 163 2305 4409 3934 -202-126 399ATOM1173 CBTYR 163 -3.198 22.912 62.1141.000 28.98ANISOU 1173 CBTYR 163 3861 3231 3920 267 1196 -1783ATOM1174 CGTYR 163 -3.342 22.997 63.6231.000 25. 58ANISOU 1174 CGTYR 163 2572 3382 3767 543 749-1204ATOM1175 CD1 TYR 163 -2.458 23.826 64.3191.000 37.32ANISOU 1175 CD1 TYR 163 3654 6112 4413 -759884-2373ATOM1176 CD2 TYR 163 -4.315 22.333 64.3451.000 29.13ANISOU 1176 CD2 TYR 163 2622 3994 4452 749 1084 -769ATOM1177 CE1 TYR 163 -2.546 23.966 65.7021.000 38.28ANISOU 1177 CE1 TYR 163 2905 7138 4503 -454987-2740ATOM1178 CE2 TYR 163 -4.396 22.431 65.7261.000 37.36ANISOU 1178 CE2 TYR 163 3220 6336 4640 -2731997 -1618ATOM1179 CZTYR 163 -3.500 23.250 66.3931.000 49.85ANISOU 1179 CZTYR 163 5272 8795 4872 -1810 1593 -2223ATOM1180 OHTYR 163 -3.595 23.365 67.7681.000 44.81ANISOU 1180 OHTYR 163 5246 7368 4413 -222270-496ATOM1181 N PHE 164 -1.098 20.651 63.4481.000 24.84ANISOU 1181 N PHE 164 2905 3368 3164 -89 -125 -361ATOM1182 CAPHE 164 -1.045 19.532 64.3701.000 28.14ANISOU 1182 CAPHE 164 3538 3957 3195 223 -163 -30ATOM1183 C PHE 164 -1.360 20.003 65.7871.000 26.67ANISOU 1183 C PHE 164 2964 3937 3234 -473-194 -257ATOM1184 O PHE 164 -0.540 20.730 66.3421.000 31.26ANISOU 1184 O PHE 164 3119 4888 3869 -959-260 -519ATOM1185 CBPHE 164 0.347 18.881 64.3961.000 27.86ANISOU 1185 CBPHE 164 3423 3725 3436 76 -199 -32ATOM1186 CGPHE 164 0.744 18.301 63.0521.000 26.77ANISOU 1186 CGPHE 164 2914 3474 3785 -59874 -275ATOM1187 CD1 PHE 164 1.435 19.093 62.1431.000 26.16ANISOU 1187 CD1 PHE 164 2827 3836 3278 135 -615 711ATOM1188 CD2 PHE 164 0.414 16.996 62.7171.000 31.24ANISOU 1188 CD2 PHE 164 4365 2808 4698 349 -298 -96ATOM1189 CE1 PHE 164 1.787 18.609 60.8941.000 30.09ANISOU 1189 CE1 PHE 164 3609 5052 2771 -148-1030 641ATOM1190 CE2 PHE 164 0.786 16.501 61.4751.000 38.25ANISOU 1190 CE2 PHE 164 66594077 3797 -740-1363 -612ATOM 1191 CZ PHE 164 1.494 17.298 60.588 1.000 32.74ANISOU 1191 CZ PHE 164 31895078 4172 712 -944 -385ATOM 1192 N PRO 165 -2.469 19.609 66.379 1.000 30.62ANISOU 1192 N PRO 165 38764009 3751 -1371 344-508ATOM 1193 CA PRO 165 -2.670 19.813 67.809 1.000 33.09ANISOU 1193 CA PRO 165 32995764 3510 -19080 236ATOM 1194 C PRO 165 -1.459 19.408 68.638 1.000 36.32ANISOU 1194 C PRO 165 35385745 4518 664 -191 -234ATOM 1195 O PRO 165 -0.776 18.428 68.371 1.000 32.94ANISOU 1195 O PRO 165 42684761 3487 220 501387ATOM 1196 CB PRO 165 -3.882 18.929 68.123 1.000 38.44ANISOU 1196 CB PRO 165 38076924 3873 -765271827ATOM 1197 CG PRO 165 -4.635 18.842 66.845 1.000 35.82ANISOU 1197 CG PRO 165 25957020 3995 5 688-828ATOM 1198 CD PRO 165 -3.690 19.130 65.710 1.000 33.90ANISOU 1198 CD PRO 165 31925919 3770 -1149 194169ATOM 1199 N LEU 178 7.727 7.45368.180 1.000 64.52ANISOU 1199 N LEU 178 12297 5376 6843 278 -218 3721ATOM 1200 CA LEU 178 7.629 8.26066.973 1.000 43.31ANISOU 1200 CA LEU 178 10557 2730 3168 -984-2821 -135ATOM 1201 C LEU 178 6.159 8.53966.662 1.000 47.36ANISOU 1201 C LEU 178 92393530 5225 -2598 -1186 1204ATOM 1202 O LEU 178 5.314 7.65966.796 1.000 56.53ANISOU 1202 O LEU 178 11777 5626 4076 -4835 1265 -602ATOM 1203 CB LEU 178 8.222 7.58265.746 1.000 55.55ANISOU 1203 CB LEU 178 11470 3734 5902 -1314 -1197 -1822ATOM 1204 CG LEU 178 9.662 7.09265.774 1.000 62.34ANISOU 1204 CG LEU 178 10812 5116 7760 -1971 194-443ATOM 1205 CD1 LEU 178 9.916 6.18564.579 1.000 54.23ANISOU 1205 CD1 LEU 178 96264989 5988 1878-3799 511ATOM 1206 CD2 LEU 178 10.633 8.26465.773 1.000 66.44ANISOU 1206 CD2 LEU 178 11265 3454 10526-1170 4090 -516ATOM 1207 N ARG 179 5.879 9.75166.192 1.000 52.90ANISOU 1207 N ARG 179 78533826 8421 102 1230 1031ATOM 1208 CA ARG 179 4.495 10.033 65.807 1.000 51.26ANISOU 1208 CA ARG 179 72354820 7421 -2291890 -383ATOM 1209 C ARG 179 4.242 9.56364.383 1.000 55.25ANISOU 1209 C ARG 179 71786083 7731 -9462260 -1134ATOM 1210 O ARG 179 3.120 9.21164.021 1.000 58.51ANISOU 1210 O ARG 179 70367628 7565 -1820 3675 -2851ATOM 1211 CB ARG 179 4.180 11.512 66.040 1.000 41.49ANISOU 1211 CB ARG 179 66004448 4716 -1551916 1137ATOM 1212 CG ARG 179 3.293 11.700 67.277 1.000 43.15ANISOU 1212 CG ARG 179 61205908 4367 90 1338 530ATOM 1213 CD ARG 179 1.888 12.059 66.833 1.000 47.63ANISOU 1213 CD ARG 179 61807453 4463 195 860-531ATOM 1214 NE ARG 179 1.459 13.367 67.269 1.000 52.00ANISOU 1214 NE ARG 179 73847834 4539 1669-1168 -538ATOM 1215 CZ ARG 179 1.322 14.470 66.556 1.000 64.81ANISOU 1215 CZ ARG 179 10838 8000 5788 1457-1107 63ATOM 1216 NH1 ARG 179 1.637 14.518 65.268 1.000 59.74ANISOU 1216 NH1 ARG 179 95358090 5074 3628-2691 445ATOM 1217 NH2 ARG 179 0.907 15.606 67.117 1.000 65.83ANISOU 1217 NH2 ARG 179 10451 9083 5478 4171-776 1200ATOM 1218 N MET 180 5.304 9.50163.589 1.000 43.96ANISOU 1218 N MET 180 53833769 7550 705 852-1245ATOM 1219 CA MET 180 5.264 9.03562.210 1.000 40.44ANISOU 1219 CA MET 180 23565467 7543 -398574-1482ATOM 1220 C MET 180 6.552 8.25861.920 1.000 43.91ANISOU 1220 C MET 180 27316220 7733 18 320-2324ATOM1221 O MET 180 7.629 8.679 62.3271.000 39.46ANISOU 1221 O MET 180 237750647554 -395906-912ATOM1222 CBMET 180 5.129 10.189 61.2191.000 49.84ANISOU 1222 CBMET 180 274979668223 -452-1114 72ATOM1223 CGMET 180 5.339 9.818 59.7571.000 62.58ANISOU 1223 CGMET 180 728089117587 -2331 -3353 -505ATOM1224 SDMET 180 4.622 11.015 58.6081.000 74.24ANISOU 1224 SDMET 180 748013510 7216 4918-262 -905ATOM1225 CEMET 180 4.501 10.037 57.1101.000 79.59ANISOU 1225 CEMET 180 611920000 4120 -1978 1874 -912ATOM1226 N ALA 181 6.376 7.112 61.2751.000 37.44ANISOU 1226 N ALA 181 352356465055 -271882-1132ATOM1227 CAALA 181 7.407 6.140 60.9861.000 37.40ANISOU 1227 CAALA 181 398039806250 -6252048 461ATOM1228 C ALA 181 8.287 6.591 59.8371.000 31.49ANISOU 1228 C ALA 181 297538425149 -32 920956ATOM1229 O ALA 181 7.834 7.393 58.9971.000 30.77ANISOU 1229 O ALA 181 290340214765 197 -98164ATOM1230 CBALA 181 6.727 4.817 60.6201.000 42.66ANISOU 1230 CBALA 181 410542847820 -1023 1629 557ATOM1231 N PRO 182 9.541 6.137 59.8401.000 24.52ANISOU 1231 N PRO 182 278242372296 -240-76320ATOM1232 CAPRO 182 10.442 6.667 58.8201.000 20.55ANISOU 1232 CAPRO 182 261228702326 -335-117 -65ATOM1233 C PRO 182 9.958 6.402 57.4081.000 19.31ANISOU 1233 C PRO 182 260924912236 -39148 -86ATOM1234 O PRO 182 9.448 5.326 57.0801.000 21.68ANISOU 1234 O PRO 182 299124862759 -440-340 -55ATOM1235 CBPRO 182 11.768 5.939 59.0471.000 24.98ANISOU 1235 CBPRO 182 258938603042 -170-286 153ATOM1236 CGPRO 182 11.681 5.351 60.3931.000 28.42ANISOU 1236 CGPRO 182 335235823863 656 3211038ATOM1237 CDPRO 182 10.215 5.210 60.7471.000 32.21ANISOU 1237 CDPRO 182 333349054000 -826-390 1785ATOM1238 N HIS 183 10.111 7.414 56.5611.000 19.27ANISOU 1238 N HIS 183 213126582533 -274-204 176ATOM1239 CAHIS 183 9.757 7.306 55.1441.000 18.01ANISOU 1239 CAHIS 183 188223112652 -341-455 346ATOM1240 C HIS 183 10.749 8.124 54.3371.000 15.74ANISOU 1240 C HIS 183 196415602456 -75 -352 128ATOM1241 O HIS 183 11.355 9.061 54.8681.000 18.14ANISOU 1241 O HIS 183 229720932504 -509-127 -135ATOM1242 CBHIS 183 8.338 7.781 54.8351.000 18.66ANISOU 1242 CBHIS 183 197021732945 -136-243 371ATOM1243 CGHIS 183 8.089 9.120 55.4471.000 26.67ANISOU 1243 CGHIS 183 310027514281 262 222-306ATOM1244 ND1 HIS 183 7.884 9.362 56.8001.000 35.36ANISOU 1244 ND1 HIS 183 443240784926 -1190 1466 -1454ATOM1245 CD2 HIS 183 8.051 10.311 54.8211.000 33.00ANISOU 1245 CD2 HIS 183 411725225898 1687-677 -173ATOM1246 CE1 HIS 183 7.739 10.658 56.9801.000 35.91ANISOU 1246 CE1 HIS 183 261144686565 -472-625 -2616ATOM1247 NE2 HIS 183 7.829 11.251 55.7981.000 40.55ANISOU 1247 NE2 HIS 183 437534177614 1821-1013 -1590ATOM1248 N TYR 184 10.890 7.778 53.0611.000 15.68ANISOU 1248 N TYR 184 197315512434 -124-470 107ATOM1249 CATYR 184 11.605 8.685 52.1521.000 14.81ANISOU 1249 CATYR 184 179813922438 147 -312 145ATOM1250 C TYR 184 10.572 9.239 51.1691.000 14.53ANISOU 1250 C TYR 184 165614492416 -70 -399 98ATOM1251 O TYR 184 9.468 8.728 51.0451.000 15.83ANISOU 1251 OTYR 184 171713832916 -103 -448 150ATOM 1252 CB TYR 184 12.699 8.004 51.3601.00015.66ANISOU 1252 CB TYR 184 168613232943 69 -366 -168ATOM 1253 CG TYR 184 12.383 6.785 50.5621.00014.85ANISOU 1253 CG TYR 184 174313132586 109 -567 43ATOM 1254 CD1 TYR 184 12.200 5.540 51.1851.00015.49ANISOU 1254 CD1 TYR 184 154913153021 -29 -575 190ATOM 1255 CD2 TYR 184 12.329 6.836 49.1651.00015.89ANISOU 1255 CD2 TYR 184 172417632552 55 -27-64ATOM 1256 CE1 TYR 184 11.962 4.396 50.4421.00015.61ANISOU 1256 CE1 TYR 184 169512442992 229 -137 113ATOM 1257 CE2 TYR 184 12.130 5.661 48.4471.00017.52ANISOU 1257 CE2 TYR 184 234017762540 483 -90ATOM 1258 CZ TYR 184 11.915 4.449 49.0831.00016.96ANISOU 1258 CZ TYR 184 169517363014 -156 -480 34ATOM 1259 OH TYR 184 11.682 3.325 48.3101.00018.81ANISOU 1259 OH TYR 184 202017753352 260 -277 -312ATOM 1260 NASP 185 10.924 10.330 50.5021.00014.36ANISOU 1260 NASP 185 151815992338 87 -225 276ATOM 1261 CA ASP 185 10.026 11.005 49.5741.00013.88ANISOU 1261 CA ASP 185 187513222078 141 -364 -42ATOM 1262 CASP 185 10.240 10.490 48.1521.00012.57ANISOU 1262 CASP 185 118213852211 -160 -77-130ATOM 1265 OASP 185 11.357 10.135 47.8241.00014.14ANISOU 1263 OASP 185 117716372559 -135 146140ATOM 1264 CB ASP 185 10.294 12.521 49.5801.00014.97ANISOU 1264 CB ASP 185 187912932517 121 -186 -159ATOM 1265 CG ASP 185 9.702 13.155 50.8301.00017.61ANISOU 1265 CG ASP 185 268016592351 232 -13-172ATOM 1266 OD1 ASP 185 9.507 12.466 51.8561.00023.69ANISOU 1266 OD1 ASP 185 355331332314 443 -302 521ATOM 1267 OD2 ASP 185 9.174 14.257 50.7421.00024.32ANISOU 1267 OD2 ASP 185 406317303449 644 1140 -16ATOM 1268 NLEU 186 9.141 10.465 47.3821.00012.57ANISOU 1268 NLEU 186 127113782126 -117 -117 -117ATOM 1269 CA LEU 186 9.169 10.091 45.9861.00012.92ANISOU 1269 CA LEU 186 153312252150 -331 -84-175ATOM 1270 CLEU 186 9.134 11.292 45.0521.00014.12ANISOU 1270 CLEU 186 173013072330 -93 -165 55ATOM 1271 OLEU 186 8.971 11.173 43.8491.00020.12ANISOU 1271 OLEU 186 372116432280 -423 99 92ATOM 1272 CB LEU 186 8.040 9.106 45.6091.00013.72ANISOU 1272 CB LEU 186 150913102393 -270 -375 -6ATOM 1273 CG LEU 186 8.020 7.811 46.4381.00015.92ANISOU 1273 CG LEU 186 154911413361 -145 -307 168ATOM 1274 CD1 LEU 186 6.929 6.908 45.8661.00019.36ANISOU 1274 CD1 LEU 186 168618453825 -700 -209 396ATOM 1275 CD2 LEU 186 9.369 7.115 46.3411.00018.32ANISOU 1275 CD2 LEU 186 168917423528 200 -432 179ATOM 1276 NSER 187 9.286 12.494 45.6181.00013.60ANISOU 1276 NSER 187 132612342608 -26 -95137ATOM 1277 CA SER 187 9.388 13.734 44.8261.00013.22ANISOU 1277 CA SER 187 148911972338 -54 -6829ATOM 1278 CSER 187 10.736 13.853 44.1341.00012.79ANISOU 1278 CSER 187 148211862192 -17 -114 -90ATOM 1279 OSER 187 11.683 13.076 44.3561.00014.50ANISOU 1279 OSER 187 153212572720 76 -224 -113ATOM 1280 CB SER 187 9.201 14.915 45.8111.00012.87ANISOU 1280 CB SER 187 146312822147 164 -154 98ATOM 1281 OG SER 187 10.296 14.873 46.7161.00013.22ANISOU 1281 OG SER 187 158914202015 -34 -143 224ATOM 1282 NMET 188 10.898 14.84443.292 1.00013.44ANISOU 1282 NMET 188 1552 1334 2221 -64 -34-26ATOM 1283 CA MET 188 12.215 15.38042.878 1.00012.11ANISOU 1283 CA MET 188 1508 1261 1833 29 -60-61ATOM 1284 CMET 188 12.853 16.02244.104 1.00012.78ANISOU 1284 CMET 188 1563 1156 2136 167 -311 -42ATOM 1285 OMET 188 13.896 15.55044.600 1.00013.40ANISOU 1285 OMET 188 1408 1390 2294 116 -264 -26ATOM 1286 CB MET 188 12.038 16.30041.667 1.00013.66ANISOU 1286 CB MET 188 1565 1501 2123 44 -161 207ATOM 1287 CG MET 188 13.296 17.09541.315 1.00014.05ANISOU 1287 CG MET 188 1697 1595 2046 66 150133ATOM 1288 SD MET 188 14.600 15.97140.752 1.00014.96ANISOU 1288 SD MET 188 1565 1591 2529 109 -81110ATOM 1289 CE MET 188 16.005 17.10240.686 1.00017.74ANISOU 1289 CE MET 188 1852 2032 2855 -242 505121ATOM 1290 NVAL 189 12.244 17.11244.616 1.00012.62ANISOU 1290 NVAL 189 1586 1203 2007 103 -147 -134ATOM 1291 CA VAL 189 12.565 17.67145.918 1.00012.60ANISOU 1291 CA VAL 189 1412 1438 1937 -228 -11-44ATOM 1292 CVAL 189 11.285 17.96846.679 1.00011.71ANISOU 1292 CVAL 189 1328 1294 1825 -170 -171 -49ATOM 1293 OVAL 189 10.227 18.09946.050 1.00012.56ANISOU 1293 OVAL 189 1446 1291 2036 21 -320 -49ATOM 1294 CB VAL 189 13.440 18.95545.856 1.00012.95ANISOU 1294 CB VAL 189 1150 1517 2252 -174 -205 94ATOM 1295 CG1 VAL 189 14.778 18.63745.167 1.00015.54ANISOU 1295 CG1 VAL 189 1376 2094 2437 -140 16191ATOM 1296 CG2 VAL 189 12.730 20.05645.082 1.00015.00ANISOU 1296 CG2 VAL 189 1763 1391 2547 -130 -483 81ATOM 1297 NTHR 190 11.425 18.06747.984 1.00012.18ANISOU 1297 NTHR 190 1445 1422 1760 -109 -130 10ATOM 1298 CA THR 190 10.353 18.45448.897 1.00011.98ANISOU 1298 CA THR 190 1292 1356 1903 -57 -221 -151ATOM 1299 CTHR 190 10.879 19.63049.710 1.00012.47ANISOU 1299 CTHR 190 1178 1436 2124 -32 -297 -232ATOM 1300 OTHR 190 11.959 19.52350.320 1.00015.06ANISOU 1300 OTHR 190 1424 1767 2531 46 -571 -446ATOM 1301 CB THR 190 9.913 17.29749.808 1.00013.16ANISOU 1301 CB THR 190 1509 1605 1886 -168 80 -121ATOM 1302 OG1 THR 190 9.481 16.20148.993 1.00014.47ANISOU 1302 OG1 THR 190 1693 1469 2334 -100 -25-194ATOM 1303 CG2 THR 190 8.778 17.72350.734 1.00014.79ANISOU 1303 CG2 THR 190 1696 1510 2415 73 258-89ATOM 1304 NLEU 191 10.148 20.72449.732 1.00012.97ANISOU 1304 NLEU 191 1329 1449 2149 23 -21-286ATOM 1305 CA LEU 191 10.511 21.90850.526 1.00013.75ANISOU 1305 CA LEU 191 1543 1442 2238 78 -206 -301ATOM 1306 CLEU 191 9.603 21.96451.763 1.00014.47ANISOU 1306 CLEU 191 1543 1689 2265 83 -179 -412ATOM 1307 OLEU 191 8.370 21.86851.645 1.00016.58ANISOU 1307 OLEU 191 1517 2486 2297 219 -176 -725ATOM 1308 CB LEU 191 10.398 23.21249.722 1.00015.37ANISOU 1308 CB LEU 191 1717 1444 2680 58 -106 -189ATOM 1309 CG LEU 191 11.705 23.57848.973 1.00016.10ANISOU 1309 CG LEU 191 1747 1688 2680 -128 -113 -135ATOM 1310 CD1 LEU 191 12.069 22.56547.906 1.00016.67ANISOU 1310 CD1 LEU 191 2034 2093 2209 -23 -6419ATOM 1311 CD2 LEU 191 11.570 24.95948.350 1.00018.53ANISOU 1311 CD2 LEU 191 2297 1906 2837 -345 -437 148ATOM 1312 NILE 192 10.199 22.14852.946 1.00015.36ANISOU 1312 NILE 192 1479 21522204 -47 -165 -164ATOM 1313 CA ILE 192 9.417 22.162 54.194 1.000 15.13ANISOU 1313 CA ILE 192 1456 20432251 -304-173 -280ATOM 1314 CILE 192 9.692 23.423 55.010 1.000 15.58ANISOU 1314 CILE 192 1696 19732251 -199-254 -226ATOM 1315 OILE 192 10.836 23.691 55.381 1.000 17.20ANISOU 1315 OILE 192 1856 24492229 -307-341 -574ATOM 1316 CB ILE 192 9.722 20.920 55.040 1.000 17.03ANISOU 1316 CB ILE 192 2246 19582266 -52 325-303ATOM 1317 CG1 ILE 192 9.454 19.596 54.317 1.000 19.80ANISOU 1317 CG1 ILE 192 3040 20102473 -71 128-382ATOM 1318 CG2 ILE 192 8.995 20.967 56.403 1.000 18.14ANISOU 1318 CG2 ILE 192 2278 23542262 229 290 -258ATOM 1319 CD1 ILE 192 9.420 18.387 55.235 1.000 31.57ANISOU 1319 CD1 ILE 192 4658 21145222 -398-1094 765ATOM 1320 NGLN 193 8.625 24.172 55.249 1.000 17.04ANISOU 1320 NGLN 193 2042 21852248 112 -388 -301ATOM 1321 CA GLN 193 8.680 25.291 56.201 1.000 17.70ANISOU 1321 CA GLN 193 1737 21672824 -204-186 -559ATOM 1322 CGLN 193 7.898 24.869 57.443 1.000 19.67ANISOU 1322 CGLN 193 1882 26242969 -232211-840ATOM 1323 OGLN 193 7.082 23.942 57.426 1.000 26.60ANISOU 1323 OGLN 193 2066 38434197 -965-110 62ATOM 1324 CB GLN 193 8.129 26.598 55.643 1.000 23.74ANISOU 1324 CB GLN 193 3070 23883561 500 -98-514ATOM 1325 CG GLN 193 8.913 27.304 54.559 1.000 28.26ANISOU 1325 CG GLN 193 4664 23843689 656 2090ATOM 1326 CD GLN 193 8.338 28.665 54.156 1.000 26.30ANISOU 1326 CD GLN 193 2868 29434181 791 3 111ATOM 1327 OE1 GLN 193 7.193 28.695 53.688 1.000 45.31ANISOU 1327 OE1 GLN 193 2826 71477241 -51 -616 3173ATOM 1328 NE2 GLN 193 9.080 29.748 54.345 1.000 30.44ANISOU 1328 NE2 GLN 193 3609 25885368 418 1259 692ATOM 1329 NGLN 194 8.241 25.259 58.645 1.000 22.04ANISOU 1329 NGLN 194 2926 27582690 303 -368 -83ATOM 1330 CA GLN 194 7.569 24.793 59.847 1.000 22.68ANISOU 1330 CA GLN 194 3144 26172855 82 -230 -150ATOM 1331 CGLN 194 7.275 26.054 60.663 1.000 22.19ANISOU 1331 CGLN 194 2809 27682856 117 -396 -320ATOM 1332 OGLN 194 7.889 27.100 60.418 1.000 25.26ANISOU 1332 OGLN 194 4041 28772679 -313-21-411ATOM 1333 CB GLN 194 8.467 23.943 60.739 1.000 29.21ANISOU 1333 CB GLN 194 4493 27073899 477 -50939ATOM 1334 CG GLN 194 9.105 22.735 60.083 1.000 28.80ANISOU 1334 CG GLN 194 3108 35304305 576 -121 494ATOM 1335 CD GLN 194 10.296 22.332 60.962 1.000 31.97ANISOU 1335 CD GLN 194 2961 53843800 824 3591075ATOM 1336 OE1 GLN 194 11.421 22.325 60.474 1.000 27.28ANISOU 1336 OE1 GLN 194 2781 41893397 118 133-249ATOM 1337 NE2 GLN 194 9.998 22.100 62.232 1.000 29.82ANISOU 1337 NE2 GLN 194 3540 39583832 989 645800ATOM 1338 NTHR 195 6.419 25.891 61.658 1.000 23.30ANISOU 1338 NTHR 195 2407 30583387 -211-235 -720ATOM 1339 CA THR 195 6.476 26.833 62.768 1.000 27.14ANISOU 1339 CA THR 195 3459 35443308 25 -50-890ATOM 1340 CTHR 195 6.933 25.997 63.958 1.000 26.11ANISOU 1340 CTHR 195 3825 28293268 558 19 -1247ATOM 1341 OTHR 195 6.639 24.815 63.994 1.000 28.17ANISOU 1341 OTHR 195 2973 29164815 481 171-1030ATOM 1342 CB THR 195 5.149 27.534 63.069 1.000 25.87ANISOU 1342 CB THR 195 3428 28493551 -16 -592 -1137ATOM 1343 OG1 THR 195 4.11126.550 63.1961.00025.45ANISOU 1343 OG1 THR 195 3427 3101 3141 -9 -117 -750ATOM 1344 CG2 THR 195 4.78828.396 61.8471.00031.31ANISOU 1344 CG2 THR 195 4965 2552 4380 274 -70-409ATOM 1345 N PRO 196 7.60426.587 64.9231.00030.84ANISOU 1345 N PRO 196 5225 3191 3300 785 -517 -1542ATOM 1346 CA PRO 196 8.10125.823 66.0651.00028.50ANISOU 1346 CA PRO 196 3113 3700 4016 -279 -441 -646ATOM 1347 C PRO 196 7.01825.534 67.0961.00028.97ANISOU 1347 C PRO 196 3581 3326 4102 42 113-1381ATOM 1348 O PRO 196 6.00226.229 67.1921.00032.32ANISOU 1348 O PRO 196 4146 4649 3485 901 -180 -1658ATOM 1349 CB PRO 196 9.09426.816 66.6941.00029.72ANISOU 1349 CB PRO 196 3888 3292 4111 -285 -353 -1072ATOM 1350 CG PRO 196 8.53328.174 66.3641.00034.87ANISOU 1350 CG PRO 196 6285 3575 3390 421 -1326 -1332ATOM 1351 CD PRO 196 7.89728.035 65.0121.00033.20ANISOU 1351 CD PRO 196 6407 3606 2600 -598 -494 -1031ATOM 1352 N CYS 197 7.28924.533 67.9191.00026.96ANISOU 1352 N CYS 197 2739 4038 3465 -113 85 -1227ATOM 1353 CA CYS 197 6.51924.289 69.1261.00031.73ANISOU 1353 CA CYS 197 3979 4543 3533 -39 721-1726ATOM 1354 C CYS 197 6.80325.412 70.1241.00035.58ANISOU 1354 C CYS 197 4213 4819 4486 -480 1126 -2282ATOM 1355 O CYS 197 7.91725.939 70.1751.00031.34ANISOU 1355 O CYS 197 3817 4845 3246 36 -383 -992ATOM 1356 CB CYS 197 6.94022.962 69.7671.00035.79ANISOU 1356 CB CYS 197 5913 4705 2980 284 1566 -1423ATOM 1357 SG CYS 197 6.55321.535 68.7411.00028.53ANISOU 1357 SG CYS 197 3605 4224 3009 50 -5 -452ATOM 1358 N ALA 198 5.77125.791 70.8661.00037.27ANISOU 1358 N ALA 198 5038 4984 4139 -421 1647 -2070ATOM 1359 CA ALA 198 5.98326.811 71.8881.00035.91ANISOU 1359 CA ALA 198 6273 4144 3230 910 522-1230ATOM 1360 C ALA 198 6.99326.328 72.9211.00044.30ANISOU 1360 C ALA 198 5998 6138 4696 -193 -199 33ATOM 1361 O ALA 198 7.75927.127 73.4571.00042.85ANISOU 1361 O ALA 198 5209 6328 4742 7 490 -555ATOM 1362 CB ALA 198 4.67127.231 72.5321.00041.70ANISOU 1362 CB ALA 198 7588 5697 2557 2355 1068 -721ATOM 1363 N ASN 199 7.03625.036 73.2251.00034.93ANISOU 1363 N ASN 199 4027 5975 3270 805 167-621ATOM 1364 CA ASN 199 7.96924.578 74.2641.00033.58ANISOU 1364 CA ASN 199 3643 6167 2950 -670 -265 -808ATOM 1365 C ASN 199 9.35224.262 73.7181.00031.53ANISOU 1365 C ASN 199 4077 5048 2853 384 -420 -855ATOM 1366 O ASN 199 10.153 23.667 74.4671.00036.33ANISOU 1366 O ASN 199 4223 5624 3957 -403 -1305 -126ATOM 1367 CB ASN 199 7.44123.308 74.9291.00036.38ANISOU 1367 CB ASN 199 4533 5029 4262 859 584-522ATOM 1368 CG ASN 199 7.19822.180 73.9521.00031.28ANISOU 1368 CG ASN 199 4030 4863 2993 882 202178ATOM 1369 OD1 ASN 199 7.74322.151 72.8531.00037.62ANISOU 1369 OD1 ASN 199 4693 6272 3330 122 728-56ATOM 1370 ND2 ASN 199 6.39321.190 74.3141.00036.42ANISOU 1370 ND2 ASN 199 3508 6251 4078 -13 1132 -958ATOM 1371 N GLY 200 9.61624.569 72.4491.00030.93ANISOU 1371 N GLY 200 4342 4232 3179 436 144-692ATOM 1372 CA GLY 200 10.920 24.304 71.8661.00035.26ANISOU 1372 CA GLY 200 4430 4905 4060 -317 480-2400ATOM 1373 C GLY 200 11.184 22.886 71.4291.00036.83ANISOU 1373 CGLY 200 468343754936 -3601601 -1460ATOM 1374 OGLY 200 12.257 22.566 70.8971.000 32.71ANISOU 1374 OGLY 200 392140724436 -377752-1400ATOM 1375 NPHE 201 10.264 21.939 71.5881.000 28.66ANISOU 1375 NPHE 201 381342292847 145 463-326ATOM 1376 CA PHE 201 10.491 20.575 71.1061.000 27.55ANISOU 1376 CA PHE 201 319043372943 -233219-672ATOM 1377 CPHE 201 10.752 20.553 69.6001.000 24.89ANISOU 1377 CPHE 201 294336822832 190 -268 -379ATOM 1378 OPHE 201 9.994 21.255 68.9101.000 28.22ANISOU 1378 OPHE 201 358331843957 10 -421 277ATOM 1379 CB PHE 201 9.250 19.729 71.4131.000 30.46ANISOU 1379 CB PHE 201 315348623560 -371-40-73ATOM 1380 CG PHE 201 9.425 18.262 71.0271.000 34.89ANISOU 1380 CG PHE 201 401546094632 -77216289ATOM 1381 CD1 PHE 201 10.395 17.472 71.6051.000 31.18ANISOU 1381 CD1 PHE 201 343641034310 -875-93-1105ATOM 1382 CD2 PHE 201 8.613 17.681 70.0781.000 28.84ANISOU 1382 CD2 PHE 201 297940193960 329 612-107ATOM 1383 CE1 PHE 201 10.564 16.160 71.2401.000 37.73ANISOU 1383 CE1 PHE 201 648936084239 -1078 -1475 -500ATOM 1384 CE2 PHE 201 8.761 16.363 69.6791.000 31.78ANISOU 1384 CE2 PHE 201 432739113838 652 250119ATOM 1385 CZ PHE 201 9.755 15.606 70.2651.000 29.78ANISOU 1385 CZ PHE 201 370533974211 6 -638 -849ATOM 1386 NVAL 202 11.706 19.751 69.1441.000 23.51ANISOU 1386 NVAL 202 267133922868 -292-1 -578ATOM 1387 CA VAL 202 11.969 19.626 67.7061.000 26.37ANISOU 1387 CA VAL 202 302540502946 -66757 -724ATOM 1388 CVAL 202 11.423 18.283 67.1981.000 22.75ANISOU 1388 CVAL 202 272933482567 96 -120 -435ATOM 1389 OVAL 202 11.880 17.190 67.5411.000 28.71ANISOU 1389 OVAL 202 324937993859 119 31 661ATOM 1390 CB VAL 202 13.476 19.721 67.4151.000 24.99ANISOU 1390 CB VAL 202 306034273008 -278283152ATOM 1391 CG1 VAL 202 13.715 19.464 65.9381.000 27.70ANISOU 1391 CG1 VAL 202 464225773307 87 1014 -3ATOM 1392 CG2 VAL 202 14.050 21.071 67.8231.000 26.80ANISOU 1392 CG2 VAL 202 282638683487 -490474-398ATOM 1393 NSER 203 10.405 18.402 66.3331.000 24.10ANISOU 1393 NSER 203 219436073356 -31 -179 -528ATOM 1394 CA SER 203 9.634 17.231 65.9401.000 23.70ANISOU 1394 CA SER 203 237335843046 -290308-533ATOM 1395 CSER 203 10.168 16.511 64.7101.000 21.28ANISOU 1395 CSER 203 217330412871 46 227-42ATOM 1396 OSER 203 10.159 15.285 64.6401.000 27.60ANISOU 1396 OSER 203 410530973284 -4821010 -249ATOM 1397 CB SER 203 8.148 17.571 65.6851.000 29.06ANISOU 1397 CB SER 203 225137905001 -180203-2064ATOM 1398 OG SER 203 7.584 18.175 66.8431.000 32.55ANISOU 1398 OG SER 203 384042984231 920 1099 -382ATOM 1399 NLEU 204 10.688 17.233 63.7241.000 22.46ANISOU 1399 NLEU 204 247630133043 79 450-46ATOM 1400 CA LEU 204 11.166 16.530 62.5441.000 20.26ANISOU 1400 CA LEU 204 220028312667 45 -18-15ATOM 1401 CLEU 204 12.595 16.038 62.7471.000 18.83ANISOU 1401 CLEU 204 215125282477 -75 60 -1ATOM 1402 OLEU 204 13.443 16.783 63.2511.000 20.47ANISOU 1402 OLEU 204 233323863059 -303-195 404ATOM 1403 CB LEU 204 11.103 17.486 61.3621.000 21.42ANISOU 1403 CB LEU 204 271825482871 311 -16-8ATOM 1404 CG LEU 204 9.769 18.188 61.0791.000 33.57ANISOU 1404 CG LEU 204 28204319 5617 177 -1316 1172ATOM 1405 CD1 LEU 204 9.797 18.747 59.6601.000 36.19ANISOU 1405 CD1 LEU 204 44023807 5540 1276-1167 987ATOM 1406 CD2 LEU 204 8.581 17.234 61.2191.000 37.76ANISOU 1406 CD2 LEU 204 30585328 5960 -526-1896 686ATOM 1407 NGLN 205 12.864 14.836 62.2841.000 20.33ANISOU 1407 NGLN 205 25182644 2563 104 -31-129ATOM 1408 CA GLN 205 14.209 14.247 62.3351.000 18.88ANISOU 1408 CA GLN 205 25222225 2425 -6 -181 36ATOM 1409 CGLN 205 14.512 13.504 61.0361.000 18.19ANISOU 1409 CGLN 205 19862383 2543 -143-188 -80ATOM 1410 OGLN 205 13.577 13.033 60.4081.000 19.87ANISOU 1410 OGLN 205 19743063 2514 -125-212 -237ATOM 1411 CB GLN 205 14.296 13.267 63.4931.000 24.25ANISOU 1411 CB GLN 205 39482716 2548 202 -343 296ATOM 1412 CG GLN 205 14.164 13.948 64.8561.000 30.64ANISOU 1412 CG GLN 205 40995159 2382 850 -327 -89ATOM 1413 CD GLN 205 14.744 13.078 65.9481.000 28.28ANISOU 1413 CD GLN 205 44733633 2640 -161-1015 -390ATOM 1414 OE1 GLN 205 14.307 11.921 66.0411.000 37.69ANISOU 1414 OE1 GLN 205 57335073 3515 -2145 -699 478ATOM 1415 NE2 GLN 205 15.710 13.553 66.7111.000 40.53ANISOU 1415 NE2 GLN 205 67984417 4185 -1341 -2865 323ATOM 1416 NALA 206 15.752 13.471 60.5761.000 18.52ANISOU 1416 NALA 206 20702199 2769 -240-134ATOM 1417 CA ALA 206 16.152 12.700 59.4051.000 18.42ANISOU 1417 CA ALA 206 20742351 2575 -100-158 23ATOM 1418 CALA 206 17.343 11.802 59.7381.000 17.41ANISOU 1418 CALA 206 21072158 2350 -185-254 -17ATOM 1419 OALA 206 18.123 12.203 60.6131.000 20.67ANISOU 1419 OALA 206 24692410 2973 -48 -711 -396ATOM 1420 CB ALA 206 16.637 13.599 58.2701.000 18.77ANISOU 1420 CB ALA 206 21192310 2703 156 -65147ATOM 1421 NGLU 207 17.492 10.764 58.9311.000 18.09ANISOU 1421 NGLU 207 20922101 2680 -249-496 -162ATOM 1422 CA GLU 207 18.710 9.944 58.9661.000 19.48ANISOU 1422 CA GLU 207 22102091 3100 -73 -432 -44ATOM 1423 CGLU 207 19.851 10.730 58.3201.000 19.98ANISOU 1423 CGLU 207 20182233 3342 220 -560 544ATOM 1424 OGLU 207 19.732 11.068 57.1431.000 20.33ANISOU 1424 OGLU 207 20002753 2970 5 -471 89ATOM 1425 CB GLU 207 18.566 8.623 58.2141.000 24.03ANISOU 1425 CB GLU 207 34011784 3946 316 -1226 61ATOM 1426 CG GLU 207 19.757 7.674 58.2951.000 24.35ANISOU 1426 CG GLU 207 32231907 4121 354 93 467ATOM 1427 CD GLU 207 20.730 7.791 57.1291.000 31.69ANISOU 1427 CD GLU 207 27295178 4134 -1218 -175 122ATOM 1428 OE1 GLU 207 20.376 7.611 55.9431.000 26.97ANISOU 1428 OE1 GLU 207 28493404 3993 31 -256 309ATOM 1429 OE2 GLU 207 21.908 8.121 57.4071.000 30.70ANISOU 1429 OE2 GLU 207 24843416 5764 -233-342 -1168ATOM 1430 NVAL 208 20.919 10.936 59.0781.000 18.53ANISOU 1430 NVAL 208 20202112 2907 130 -362 320ATOM 1431 CA VAL 208 22.150 11.547 58.5411.000 19.53ANISOU 1431 CA VAL 208 20442238 3137 39 -476 630ATOM 1432 CVAL 208 23.341 10.755 59.0881.000 21.95ANISOU 1432 CVAL 208 20402792 3507 225 -461 797ATOM 1433 OVAL 208 23.460 10.663 60.3141.000 23.82ANISOU 1433 OVAL 208 22623240 3547 -40 -858 825ATOM 1434 CB VAL 208 22.271 13.027 58.9051.000 19.72AMISOU 1434 CB VAL 208 19182429 3145 -47 -308 311ATOM 1435 CG1 VAL 208 23.524 13.626 58.281 1.000 23.14ANISOU 1435 CG1 VAL 208 25242374 3895 -202284349ATOM 1436 CG2 VAL 208 21.030 13.812 58.469 1.000 19.47ANISOU 1436 CG2 VAL 208 24622279 2658 232 -667 -87ATOM 1437 N GLY 209 24.180 10.169 58.246 1.000 23.88ANISOU 1437 N GLY 209 25002449 4123 465 -711 36ATOM 1438 CA GLY 209 25.306 9.37458.773 1.000 26.42ANISOU 1438 CA GLY 209 19873599 4450 460 -487 516ATOM 1439 C GLY 209 24.905 8.25059.695 1.000 30.01ANISOU 1439 C GLY 209 34693240 4693 238 -1422 732ATOM 1440 O GLY 209 25.609 7.83560.629 1.000 31.45ANISOU 1440 O GLY 209 40534458 3438 1225-897 83ATOM 1441 N GLY 210 23.691 7.70259.523 1.000 26.64ANISOU 1441 N GLY 210 31653214 3744 259 -86350ATOM 1442 CA GLY 210 23.263 6.58560.360 1.000 29.78ANISOU 1442 CA GLY 210 46033091 3619 -55 -997 584ATOM 1443 C GLY 210 22.622 6.99361.663 1.000 38.28ANISOU 1443 C GLY 210 58274212 4507 -2536 73250ATOM 1444 O GLY 210 22.160 6.18762.481 1.000 41.45ANISOU 1444 O GLY 210 41526516 5082 -1874 -567 2346ATOM 1445 N ALA 211 22.512 8.27461.976 1.000 32.81ANISOU 1445 N ALA 211 48034625 3037 1372-1177 632ATOM 1446 CA ALA 211 21.828 8.60363.235 1.000 35.62ANISOU 1446 CA ALA 211 39935958 3584 1061-610 970ATOM 1447 C ALA 211 20.663 9.54362.940 1.000 31.43ANISOU 1447 C ALA 211 35084737 3699 302 69 1854ATOM 1448 O ALA 211 20.652 10.097 61.858 1.000 28.28ANISOU 1448 O ALA 211 36614062 3020 -571-551 1010ATOM 1449 CB ALA 211 22.812 9.27864.170 1.000 41.36ANISOU 1449 CB ALA 211 36448904 3169 1372-18-791ATOM 1450 N PHE 212 19.682 9.67663.825 1.000 36.68ANISOU 1450 N PHE 212 52114237 4489 11661265 2171ATOM 1451 CA PHE 212 18.620 10.654 63.641 1.000 28.82ANISOU 1451 CA PHE 212 44903167 3293 263 5041037ATOM 1452 C PHE 212 19.100 12.023 64.124 1.000 34.72ANISOU 1452 C PHE 212 67463760 2685 -248-539 776ATOM 1453 O PHE 212 19.667 12.191 65.210 1.000 39.12ANISOU 1453 O PHE 212 61445384 3335 -549-1129 1220ATOM 1454 CB PHE 212 17.358 10.219 64.388 1.000 45.35ANISOU 1454 CB PHE 212 63762569 8288 13483748 2314ATOM 1455 N THR 213 18.906 13.008 63.271 1.000 26.30ANISOU 1455 N THR 213 41342738 3122 662 -581 100ATOM 1456 CA THR 213 19.424 14.359 63.433 1.000 25.08ANISOU 1456 CA THR 213 35872852 3089 767 -810 -323ATOM 1457 C THR 213 18.190 15.283 63.400 1.000 23.81ANISOU 1457 C THR 213 28352652 3560 215 -855 -643ATOM 1458 O THR 213 17.329 15.137 62.517 1.000 21.40ANISOU 1458 O THR 213 26402269 3223 -328-580 -179ATOM 1459 CB THR 213 20.398 14.759 62.308 1.000 27.60ANISOU 1459 CB THR 213 31553220 4113 189 -356 -798ATOM 1460 OG1 THR 213 21.673 14.084 62.374 1.000 32.00ANISOU 1460 OG1 THR 213 35824220 4356 746 -410 520ATOM 1461 CG2 THR 213 20.735 16.254 62.355 1.000 29.45ANISOU 1461 CG2 THR 213 44223320 3448 -106-1265 -204ATOM 1462 N ASP 214 18.119 16.177 64.371 1.000 21.05ANISOU 1462 N ASP 214 27902236 2972 -82 -380 -142ATOM 1463 CA ASP 214 17.001 17.110 64.462 1.000 20.61ANISOU 1463 CA ASP 214 27422095 2993 -117-898 -379ATOM 1464 C ASP 214 16.994 18.030 63.226 1.000 20.58ANISOU 1464 C ASP 214 23732525 2923 182 -169 -237ATOM1465 OASP 214 18.018 18.430 62.6781.000 23.02ANISOU 1465 OASP 214 24612883 3404 -167-52-572ATOM1466 CB ASP 214 17.205 18.058 65.6371.000 23.54ANISOU 1466 CB ASP 214 33042607 3032 -92 -748 -668ATOM1467 CG ASP 214 16.915 17.506 67.0041.000 24.93ANISOU 1467 CG ASP 214 35452850 3079 450 -417 -614ATOM1468 OD1 ASP 214 16.357 16.395 67.1131.000 29.17ANISOU 1468 OD1 ASP 214 41343070 3878 202 -705 262ATOM1469 OD2 ASP 214 17.276 18.191 67.9901.000 34.38ANISOU 1469 OD2 ASP 214 69173040 3107 1017-1413 -736ATOM1470 NLEU 215 15.802 18.452 62.8591.000 20.74ANISOU 1470 NLEU 215 24262372 3081 86 -60306ATOM1471 CA LEU 215 15.568 19.401 61.7961.000 20.55ANISOU 1471 CA LEU 215 28952013 2899 -202-178 141ATOM1472 CLEU 215 14.724 20.552 62.3321.000 19.02ANISOU 1472 CLEU 215 24822240 2504 -142-34321ATOM1473 OLEU 215 13.510 20.613 62.1421.000 22.39ANISOU 1473 OLEU 215 26352483 3389 -160-475 573ATOM1474 CB LEU 215 14.826 18.722 60.6501.000 22.04ANISOU 1474 CB LEU 215 27782510 3086 -140-261 -65ATOM1475 CG LEU 215 15.598 17.502 60.1281.000 25.25ANISOU 1475 CG LEU 215 36802829 3085 85 -166 -402ATOM1476 CD1 LEU 215 14.680 16．73659.1741.000 27.12ANISOU 1476 CD1 LEU 215 48862934 2482 419 -1128 -65ATOM1477 CD2 LEU 215 16.881 18.046 59.5101.000 30.76ANISOU 1477 CD2 LEU 215 34343089 5165 1003524561ATOM1478 NPRO 216 15.383 21.433 63.0781.000 19.68ANISOU 1478 NPRO 216 24072191 2879 -157148103ATOM1479 CA PRO 216 14.665 22.534 63.7081.000 22.42ANISOU 1479 CA PRO 216 28692812 2836 272 10 -228ATOM1480 CPRO 216 14.201 23.576 62.6981.000 25.36ANISOU 1480 CPRO 216 41182433 3086 566 -131 -315ATOM1481 OPRO 216 14.700 23.759 61.5861.000 24.67ANISOU 1481 OPRO 216 36822406 3284 187 -176 -26ATOM1482 CB PRO 216 15.693 23.092 64.6761.000 23.88ANISOU 1482 CB PRO 216 31083049 2917 -216116-318ATOM1483 CG PRO 216 17.033 22.701 64.1461.000 28.31ANISOU 1483 CG PRO 216 29942996 4766 -88 -117 -1454ATOM1484 CD PRO 216 16.807 21.405 63.4361.000 24.55ANISOU 1484 CD PRO 216 23531777 5197 -436-83-348ATOM1485 NTYR 217 13.154 24.287 63.1021.000 24.13ANISOU 1485 NTYR 217 32372704 3229 244 -631 -511ATOM1486 CA TYR 217 12.676 25.510 62.4621.000 26.08ANISOU 1486 CA TYR 217 25142899 4498 104 -592 39ATOM1487 CTYR 217 13.824 26.516 62.3691.000 25.24ANISOU 1487 CTYR 217 30492948 3592 -257-506 -538ATOM1488 OTYR 217 14.570 26.675 63.3401.000 31.78ANISOU 1488 OTYR 217 41142863 5096 -352-2151 564ATOM1489 CB TYR 217 11.559 26.103 63.3151.000 25.97ANISOU 1489 CB TYR 217 27472773 4346 86 -615 -167ATOM1490 CG TYR 217 11.189 27.543 63.1251.000 31.64ANISOU 1490 CG TYR 217 30802803 6139 338 -1473 -644ATOM1491 CD1 TYR 217 10.430 27.928 62.0221.000 27.85ANISOU 1491 CD1 TYR 217 22383029 5314 511 -175 93ATOM1492 CD2 TYR 217 11.512 28.522 64.0691.000 38.49ANISOU 1492 CD2 TYR 217 47212813 7093 -686-1682 -749ATOM1493 CE1 TYR 217 10.021 29.219 61.7721.000 26.53ANISOU 1493 CE1 TYR 217 19082675 5496 -41 10769ATOM1494 CE2 TYR 217 11.113 29.835 63.8271.000 42.90ANISOU 1494 CE2 TYR 217 71122347 6842 -1415 -1949 -218ATOM1495 CZ TYR 217 10.373 30.168 62.7121.000 34.93ANISOU 1495 CZTYR 217 404227476483 -1462 -545 166ATOM 1496 OHTYR 217 9.996 31.486 62.4731.000 36.41ANISOU 1496 OHTYR 217 549928955439 -753-250 -289ATOM 1497 N ARG 218 14.022 27.110 61.2181.000 25.58ANISOU 1497 N ARG 218 346124063852 -227-533 -476ATOM 1498 CAARG 218 14.923 28.243 61.0491.000 29．26ANISOU 1498 CAARG 218 363032704219 -784-1349 268ATOM 1499 C ARG 218 14.113 29.336 60.3661.000 24.81ANISOU 1499 C ARG 218 406329492415 -382-228 -56ATOM 1500 O ARG 218 13.746 29.174 59.2121.000 29.56ANISOU 1500 O ARG 218 629822672666 -890-994 165ATOM 1501 CBARG 218 16.162 27.823 60.2561.000 35.90ANISOU 1501 CBARG 218 322336856732 -624-703 896ATOM 1502 CGARG 218 17.369 28.665 60.6611.000 51.38ANISOU 1502 CGARG 218 474067688015 -3031 430-183ATOM 1503 CDARG 218 18.539 28.606 59.7011.000 38.84ANISOU 1503 CDARG 218 496863083482 -3596 -1165 1647ATOM 1504 NEARG 218 19.343 27.395 59.9051.000 45.09ANISOU 1504 NEARG 218 465574954982 -2325 -962 -94ATOM 1505 CZARG 218 20.272 27.208 58.9591.000 55.53ANISOU 1505 CZARG 218 529911458 4340 -2701 -1188 -1948ATOM 1506 NH1 ARG 218 20.289 28.158 58.0311.000 60.85ANISOU 1506 NH1 ARG 218 239916648 4071 -1943 -1333 548ATOM 1507 NH2 ARG 218 21.060 26.165 59.0011.000 60.37ANISOU 1507 NH2 ARG 218 858010111 4247 -2152 639-4241ATOM 1508 N PRO 219 13.871 30.496 60.9721.000 25.89ANISOU 1508 N PRO 219 262541263086 35 296-1014ATOM 1509 CAPRO 219 13.065 31.548 60.3261.000 28.10ANISOU 1509 CAPRO 219 282831204730 -410379-696ATOM 1510 C PRO 219 13.636 31.959 58.9811.000 28.43ANISOU 1510 C PRO 219 314130104653 -190116-328ATOM 1511 O PRO 219 12.904 32.393 58.0811.000 34.17ANISOU 1511 O PRO 219 473435004750 302 -798 -893ATOM 1512 CBPRO 219 13.115 32.717 61.3161.000 39.70ANISOU 1512 CBPRO 219 562136125852 -5001615 -1527ATOM 1513 CGPRO 219 13.368 32.033 62.6281.000 42.38ANISOU 1513 CGPRO 219 613952774688 -2572084 -2086ATOM 1514 CDPRO 219 14.370 30.943 62.2891.000 32.77ANISOU 1514 CDPRO 219 390157192831 -602828-1603ATOM 1515 N ASP 220 14.950 31.824 58.8111.000 25.65ANISOU 1515 N ASP 220 332815824837 -276801-878ATOM 1516 CAASP 220 15.590 32.280 57.5871.000 26.45ANISOU 1516 CAASP 220 359421154341 -782248-861ATOM 1517 C ASP 220 15.781 31.305 56.4511.000 28.46ANISOU 1517 C ASP 220 354918435423 -1111638 -943ATOM 1518 O ASP 220 16.432 31.620 55.4331.000 25.80ANISOU 1518 O ASP 220 324920214533 -140623-412ATOM 1519 CBASP 220 16.911 32.962 57.9981.000 33.76ANISOU 1519 CBASP 220 235135396938 -4451187 -1724ATOM 1520 CGASP 220 17.882 31.913 58.5021.000 42.36ANISOU 1520 CGASP 220 265335319912 -812230-957ATOM 1521 OD1 ASP 220 17.484 31.170 59.4231.000 37.00ANISOU 1521 OD1 ASP 220 315441486757 -104-41O -2001ATOM 1522 OD2 ASP 220 18.981 31.787 57.9571.000 37.34ANISOU 1522 OD2 ASP 220 252047006969 93 -824 -1266ATOM 1523 N ALA 221 15.292 30.072 56.5371.000 24.79ANISOU 1523 N ALA 221 414818723398 -252671-659ATOM 1524 CAALA 221 15.695 29.016 55.5961.000 19.17ANISOU 1524 CAALA 221 216518683251 -52 -92-610ATOM 1525 C ALA 221 14.551 27.996 55.4791.000 18.60ANISOU 1525 C ALA 221 192022382908 -82 -207 -362ATOM 1526 OALA 221 13.763 27.852 56.4151.000 26.47ANISOU 1526 OALA 221 412726413289 -1307 894-904ATOM 1527 CB ALA 221 16.939 28.316 56.1041.000 19.36ANISOU 1527 CB ALA 221 205423332969 -537-316 66ATOM 1528 NVAL 222 14.490 27.385 54.3131.000 17.35ANISOU 1528 NVAL 222 208918412661 -101-323 -154ATOM 1529 CA VAL 222 13.556 26.276 54.0831.000 17.45ANISOU 1529 CA VAL 222 162020043004 -66 -417 19ATOM 1530 CVAL 222 14.333 24.965 54.0771.000 15.69ANISOU 1530 CVAL 222 161618762471 -269-349 -324ATOM 1531 OVAL 222 15.512 24.934 53.7161.000 17.84ANISOU 1531 OVAL 222 165817303390 -108-194 48ATOM 1532 CB VAL 222 12.822 26.433 52.7471.000 19.60ANISOU 1532 CB VAL 222 226722022979 91 -666 -304ATOM 1533 CG1 VAL 222 13.781 26.363 51.5631.000 21.96ANISOU 1533 CG1 VAL 222 225231132977 250 -645 -182ATOM 1534 CG2 VAL 222 11.730 25.411 52.4901.000 22.44ANISOU 1534 CG2 VAL 222 292325373067 -497-898 44ATOM 1535 NLEU 223 13.789 23.892 54.6211.000 16.30ANISOU 1535 NLEU 223 179216942706 -239-93-532ATOM 1536 CA LEU 223 14.407 22.575 54.5791.000 15.91ANISOU 1536 CA LEU 223 167918642503 -93 -297 -333ATOM 1537 CLEU 223 14.114 21.908 53.2431.000 14.86ANISOU 1537 CLEU 223 133715372773 -141-322 -458ATOM 1538 OLEU 223 12.969 21.888 52.7661.000 16.23ANISOU 1538 OLEU 223 131721322719 70 -391 -281ATOM 1539 CB LEU 223 13.829 21.779 55.7611.000 19.97ANISOU 1539 CB LEU 223 274019452901 -121205-212ATOM 1540 CG LEU 223 14.298 20.348 55.8821.000 23.01ANISOU 1540 CG LEU 223 266818714205 -375-170 91ATOM 1541 CD1 LEU 223 15.797 20.322 56.1431.000 23.73ANISOU 1541 CD1 LEU 223 257030673378 69 135316ATOM 1542 CD2 LEU 223 13.492 19.668 56.9791.000 35.71ANISOU 1542 CD2 LEU 223 281332967459 525 1116 2333ATOM 1543 NVAL 224 15.115 21.370 52.5701.000 14.18ANISOU 1543 NVAL 224 138314462560 -28 -320 -205ATOM 1544 CA VAL 224 14.956 20.627 51.3301.000 14.52ANISOU 1544 CA VAL 224 158515012431 -23 -323 -127ATOM 1545 CVAL 224 15.320 19.160 51.5611.000 13.59ANISOU 1545 CVAL 224 146415222178 23 -290 -251ATOM 1546 OVAL 224 16.442 18.861 51.9811.000 15.38ANISOU 1546 OVAL 224 146415582822 0 -505 -374ATOM 1547 CB VAL 224 15.832 21.209 50.2221.000 14.25ANISOU 1547 CB VAL 224 140216062407 -60 -461 -108ATOM 1548 CG1 VAL 224 15.685 20.443 48.9061.000 16.63ANISOU 1548 CG1 VAL 224 168221642474 -159-408 -421ATOM 1549 CG2 VAL 224 15.575 22.687 50.0401.000 16.40ANISOU 1549 CG2 VAL 224 180715622863 6 -509 87ATOM 1550 NPHE 225 14.340 18.299 51.2991.000 13.49ANISOU 1550 NPHE 225 149415262106 -66 -353 -130ATOM 1551 CA PHE 225 14.647 16.882 51.1621.000 14.67ANISOU 1551 CA PHE 225 163915052431 -115-61-283ATOM 1552 CPHE 225 14.756 16.533 49.6751.000 14.27ANISOU 1552 CPHE 225 153615332352 100 -260 -194ATOM 1553 OPHE 225 13.858 16.876 48.8931.000 16.25ANISOU 1553 OPHE 225 160420002569 296 -311 -88ATOM 1554 CB PHE 225 13.537 15.999 51.7491.000 15.57ANISOU 1554 CB PHE 225 161315632740 -25 -4624ATOM 1555 CG PHE 225 13.387 15.996 53.2571.000 17.95ANISOU 1555 CG PHE 225 188822672666 -650-302 203ATOM 1556 CD1 PHE 225 14.409 15.809 54.1571.000 27.39ANISOU 1556 CD1 PHE 225 274042343431 -910 -1094 900ATOM 1557 CD2 PHE 225 12.125 15.863 53.8201.00021.09ANISOU 1557 CD2 PHE 225 233327652917 -166 399-527ATOM 1558 CE1 PME 225 14.211 15.673 55.5211.00026.82ANISOU 1558 CE1 PHE 225 310836573424 -1044-1241 1128ATOM 1559 CE2 PHE 225 11.910 15.910 55.1861.00021.65ANISOU 1559 CE2 PHE 225 299424142817 623 239-39ATOM 1560 CZ PHE 225 12.958 15.787 56.0781.00028.82ANISOU 1560 CZ PHE 225 370537163531 -832 -663 340ATOM 1561 NCYS 226 15.795 15.817 49.2661.00012.77ANISOU 1561 NCYS 226 142812922131 -60 -370 -239ATOM 1562 CA CYS 226 15.810 15.180 47.9561.00012.99ANISOU 1562 CA CYS 226 136014402135 12 -355 -207ATOM 1563 CCYS 226 14.903 13.956 47.9851.00012.37ANISOU 1563 CCYS 226 153312121955 8-283 -311ATOM 1564 OCYS 226 14.961 13.217 48.9741.00015.68ANISOU 1564 OCYS 226 188516512424 -140 -611 158ATOM 1565 CB CYS 226 17.228 14.855 47.5271.00013.77ANISOU 1565 CB CYS 226 141016272193 19 -203 -75ATOM 1566 SG CYS 226 18.224 16.367 47.3141.00016.37ANISOU 1566 SG CYS 226 174417402735 -222 -236 -12ATOM 1567 NGLY 227 14.150 13.722 46.9281.00013.20ANISOU 1567 NGLY 227 138815132113 -28 -293 -290ATOM 1568 CA GLY 227 13.352 12.496 46.8991.00012.58ANISOU 1568 CA GLY 227 127916311872 -83 -438 -255ATOM 1569 CGLY 227 13.903 11.541 45.8491.00012.54ANISOU 1569 CGLY 227 151812791965 15 -288 -79ATOM 1570 OGLY 227 14.917 11.732 45.1521.00013.58ANISOU 1570 OGLY 227 163015232008 51 -155 82ATOM 1571 NALA 228 13.212 10.400 45.7121.00013.02ANISOU 1571 NALA 228 149013062151 59 -204 -161ATOM 1572 CA ALA 228 13.663 9.321 44.8601.00012.41ANISOU 1572 CA ALA 228 164911551912 -68 -119 -63ATOM 1573 CALA 228 13.706 9.727 43.4041.00012.82ANISOU 1573 CALA 228 156612882016 97 -223 -5ATOM 1574 OALA 228 14.482 9.132 42.6511.00013.64ANISOU 1574 OALA 228 171714622004 26 -6 -131ATOM 1575 CB ALA 228 12.714 8.121 45.0581.00014.56ANISOU 1575 CB ALA 228 180813662356 -219 358-243ATOM 1576 NILE 229 12.909 10.695 42.9521.00013.61ANISOU 1576 NILE 229 134013912441 -43 -289 273ATOM 1577 CA ILE 229 13.024 11.131 41.5661.00012.93ANISOU 1577 CA ILE 229 132512432344 -42 -306 173ATOM 1578 CILE 229 14.342 11.864 41.3581.00013.17ANISOU 1578 CILE 229 132713642311 -47 -191 130ATOM 1579 OILE 229 14.938 11.746 40.2621.00014.41ANISOU 1579 OILE 229 158715962293 -37 -167 183ATOM 1580 CB ILE 229 11.768 11.888 41.1031.00013.46ANISOU 1580 CB ILE 229 147016312015 171 -354 -42ATOM 1581 CG1 ILE 229 10.599 10.920 40.9731.00015.72ANISOU 1581 CG1 ILE 229 121819362817 85 31 118ATOM 1582 CG2 ILE 229 12.040 12.674 39.8081.00014.19ANISOU 1582 CG2 ILE 229 167014252298 76 -364 174ATOM 1583 CD1 ILE 229 10.745 9.924 39.8361.00020.03ANISOU 1583 CD1 ILE 229 212918143667 -208 -385 -488ATOM 1584 NALA 230 14.877 12.575 42.3531.00013.38ANISOU 1584 NALA 230 125213782454 -97 -176 74ATOM 1585 CA ALA 230 16.209 13.185 42.1301.00012.30ANISOU 1585 CA ALA 230 115614442074 66 -97-108ATOM 1586 CALA 230 17.223 12.033 41.9761.00012.89ANISOU 1586 CALA 230 149113272079 128 30 -20ATOM 1587 O ALA 230 18.100 12.091 41.1461.000 13.65ANISOU 1587 O ALA 230 12401530 2418 108 4 46ATOM 1588 CBALA 230 16.588 14.000 43.3451.000 13.66ANISOU 1588 CBALA 230 15591415 2215 -186-21-229ATOM 1589 N THR 231 17.143 10.978 42.8051.000 13.31ANISOU 1589 N THR 231 15261318 2214 58 -261 -1ATOM 1590 CATHR 231 18.022 9.815 42.6591.000 13.32ANISOU 1590 CATHR 231 16601307 2093 78 -302 32ATOM 1591 C THR 231 17.906 9.224 41.2511.000 13.27ANISOU 1591 C THR 231 13001631 2111 205 -211 3ATOM 1592 O THR 231 18.932 8.974 40.6201.000 15.51ANISOU 1592 O THR 231 14681759 2667 245 58 -170ATOM 1593 CBTHR 231 17.656 8.751 43.6881.000 13.03ANISOU 1593 CBTHR 231 15001302 2151 46 -166 12ATOM 1594 OG1 THR 231 17.530 9.313 44.9951.000 14.70ANISOU 1594 OG1 THR 231 17421614 2230 -99 32 -14ATOM 1595 CG2 THR 231 18.698 7.621 43.6971.000 13.69ANISOU 1595 CG2 THR 231 14491419 2335 113 -211 197ATOM 1596 N LEU 232 16.665 9.049 40.7961.000 13.43ANISOU 1596 N LEU 232 14471384 2271 75 -404 -27ATOM 1597 CALEU 232 16.446 8.396 39.5271.000 14.11ANISOU 1597 CALEU 232 18091226 2326 80 -468 49ATOM 1598 C LEU 232 16.975 9.248 38.3811.000 15.53ANISOU 1598 C LEU 232 19681557 2376 209 -3 90ATOM 1599 O LEU 232 17.749 8.808 37.5041.000 17.16ANISOU 1599 O LEU 232 20241949 2546 107 -116 -519ATOM 1600 CBLEU 232 14.940 8.135 39.3681.000 14.47ANISOU 1600 CBLEU 232 16921630 2175 72 -396 -161ATOM 1601 CGLEU 232 14.525 7.307 38.1551.000 15.89ANISOU 1601 CGLEU 232 19411768 2329 120 -470 -303ATOM 1602 CD1 LEU 232 15.118 5.920 38.2021.000 23.19ANISOU 1602 CD1 LEU 232 35652020 3228 743 -1110 -851ATOM 1603 CD2 LEU 232 13.003 7.190 38.1261.000 19.46ANISOU 1603 CD2 LEU 232 20062262 3126 -470-523 -66ATOM 1604 N VAL 233 16.539 10.514 38.2991.000 13.73ANISOU 1604 N VAL 233 17361454 2025 -7 -263 193ATOM 1605 CAVAL 233 16.893 11.317 37.1171.000 13.84ANISOU 1605 CAVAL 233 16741658 1926 141 -73107ATOM 1606 C VAL 233 18.407 11.510 37.0251.000 14.08ANISOU 1606 C VAL 233 17161674 1958 72 -46113ATOM 1607 O VAL 233 18.940 11.587 35.9101.000 16.65ANISOU 1607 O VAL 233 19232325 2079 38 109401ATOM 1608 CEVAL 233 16.098 12.626 37.0621.000 14.69ANISOU 1608 CBVAL 233 16801696 2206 141 -165 333ATOM 1609 CG1 VAL 233 16.529 13.650 38.1131.000 15.70ANISOU 1609 CG1 VAL 233 16151654 2698 34 156-28ATOM 1610 CG2 VAL 233 16.117 13.206 35.6471.000 16.43ANISOU 1610 CG2 VAL 233 17402041 2459 251 117596ATOM 1611 N THR 234 19.100 11.594 38.1751.000 14.23ANISOU 1611 N THR 234 15991724 2083 146 -110 235ATOM 1612 CATHR 234 20.524 11.908 38.1481.000 16.14ANISOU 1612 CATHR 234 16641868 2602 63 -171 -49ATOM 1613 C THR 234 21.346 10.621 38.0061.000 17.09ANISOU 1613 C THR 234 17171865 2912 146 211-51ATOM 1614 O THR 234 22.558 10.644 38.1391.000 17.25ANISOU 1614 O THR 234 17761951 2828 108 200229ATOM 1615 CBTHR 234 21.030 12.681 39.3731.000 15.29ANISOU 1615 CBTHR 234 16671502 2642 -46 -149 163ATOM 1616 OG1 THR 234 20.849 11.819 40.5221.000 15.45ANISOU 1616 OG1 THR 234 16591708 2502 -80 59 44ATOM 1617 CG2 THR 234 20.291 13.978 39.5971.000 16.61ANISOU 1617 CG2 THR 234 156416723077 3-34-42ATOM 1618 NGLY 235 20.712 9.441 37.8331.00016.80ANISOU 1618 NGLY 235 190519142564 193 29 -219ATOM 1619 CA GLY 235 21.484 8.209 37.7921.00017.10ANISOU 1619 CA GLY 235 204918612586 133 223-488ATOM 1620 CGLY 235 22.225 7.931 39.0831.00018.06ANISOU 1620 CGLY 235 204620492768 419 499303ATOM 1621 OGLY 235 23.285 7.289 39.0101.00021.26ANISOU 1621 OGLY 235 216726063303 679 343-74ATOM 1622 NGLY 236 21.602 8.149 40.2371.00016.17ANISOU 1622 NGLY 236 166319012582 36 291305ATOM 1623 CA GLY 236 22.080 7.673 41.5201.00017.27ANISOU 1623 CA GLY 236 213516712754 225 28 229ATOM 1624 CGLY 236 23.033 8.639 42.1941.00016.88ANISOU 1624 CGLY 236 188018902644 204 100222ATOM 1625 OGLY 236 23.692 8.272 43.1931.00019.42ANISOU 1625 OGLY 236 216523992814 314 -90419ATOM 1626 NGLN 237 23.134 9.890 41.7461.00016.99ANISOU 1626 NGLN 237 164718512957 213 -213 167ATOM 1627 CA GLN 237 24.074 10.849 42.2981.00016.75ANISOU 1627 CA GLN 237 160820042752 72 17798ATOM 1628 CGLN 237 23.481 11.604 43.4831.00015.64ANISOU 1628 CGLN 237 140421362402 231 -146 200ATOM 1629 OGLN 237 24.183 12.382 44.1641.00018.17ANISOU 1629 OGLN 237 158125082817 -227 -6 -46ATOM 1630 CB GLN 237 24.456 11.855 41.2171.00017.17ANISOU 1630 CB GLN 237 191220802532 71 141-7ATOM 1631 CG GLN 237 25.304 11.221 40.1151.00017.64ANISOU 1631 CG GLN 237 185024102441 226 95 -30ATOM 1632 CD GLN 237 25.721 12.302 39.1371.00019.72ANISOU 1632 CD GLN 237 168028332979 104 317307ATOM 1633 OE1 GLN 237 26.602 13.110 39.4361.00024.27ANISOU 1633 OE1 GLN 237 184131454234 -213 -187 809ATOM 1634 NE2 GLN 237 24.986 12.399 38.0271.00018.53ANISOU 1634 NE2 GLN 237 200722982735 432 374202ATOM 1635 NVAL 238 22.221 11.359 43.8071.00014.75ANISOU 1635 NVAL 238 156318042237 -32 -5443ATOM 1636 CA VAL 238 21.533 12.075 44.8621.00014.41ANISOU 1636 CA VAL 238 153515532388 0-4432ATOM 1637 CVAL 238 20.861 11.060 45.7811.00013.56ANISOU 1637 CVAL 238 141413922346 82 55 -149ATOM 1638 OVAL 238 20.136 10.174 45.3021.00015.87ANISOU 1638 OVAL 238 165516392737 -218 -285 -22ATOM 1639 CB VAL 238 20.467 13.061 44.3091.00014.73ANISOU 1639 CB VAL 238 181716262152 35 -437 -95ATOM 1640 CG1 VAL 238 19.805 13.764 45.4891.00015.70ANISOU 1640 CG1 VAL 238 196514902510 174 -524 -423ATOM 1641 CG2 VAL 238 21.064 13.994 43.2801.00016.82ANISOU 1641 CG2 VAL 238 186217182812 -60 -378 222ATOM 1642 NLYS 239 21.119 11.153 47.0711.00014.47ANISOU 1642 NLYS 239 170414742318 14 -4012ATOM 1643 CA LYS 239 20.470 10.360 48.1041.00014.43ANISOU 1643 CA LYS 239 146016172406 106 -168 179ATOM 1644 CLYS 239 19.048 10.852 48.4091.00014.82ANISOU 1644 CLYS 239 153314562642 102 -53232ATOM 1645 OLYS 239 18.839 12.067 48.4571.00014.74ANISOU 1645 OLYS 239 184114422318 158 -275 190ATOM 1646 CB LYS 239 21.320 10.435 49.3851.00016.40ANISOU 1646 CB LYS 239 199517122527 243 -543 252ATOM 1647 CG LYS 239 20.767 9.549 50.4981.00016.65ANISOU 1647 CG LYS 239 195417592614 -58 -781 244ATOM 1648 CD LYS 239 21.738 9.51151.683 1.00019.76ANISOU 1648 CD LYS 239 2954 1820 2732 -123-1234 363ATOM 1649 CE LYS 239 21.107 8.83552.896 1.00022.58ANISOU 1649 CE LYS 239 3331 2164 3086 -652-1502 863ATOM 1650 NZ LYS 239 21.904 8.88354.145 1.00023.13ANISOU 1650 NZ LYS 239 2817 3360 2612 -471-943 287ATOM 1651 N ALA 240 18.140 9.89248.659 1.00014.35ANISOU 1651 N ALA 240 1429 1607 2418 -156-334 -61ATOM 1652 CA ALA 240 16.791 10.192 49.145 1.00013.98ANISOU 1652 CA ALA 240 1468 1635 2210 -151-335 -10ATOM 1653 C ALA 240 16.728 9.77650.605 1.00013.44ANISOU 1653 C ALA 240 1439 1388 2279 77 -450 22ATOM 1654 O ALA 240 16.514 8.59250.913 1.00016.32ANISOU 1654 O ALA 240 1932 1567 2699 -215-673 314ATOM 1655 CB ALA 240 15.712 9.56548.268 1.00015.21ANISOU 1655 CB ALA 240 1510 1962 2306 -104-387 -307ATOM 1656 N PRO 241 16.907 10.701 51.546 1.00014.23ANISOU 1656 N PRO 241 1634 1551 2221 -87 -292 71ATOM 1657 CA PRO 241 17.035 10.251 52.940 1.00014.68ANISOU 1657 CA PRO 241 1718 1681 2180 -350-174 -30ATOM 1658 C PRO 241 15.693 9.96153.579 1.00013.89ANISOU 1658 C PRO 241 1659 1581 2039 -107-207 -74ATOM 1659 O PRO 241 14.629 10.527 53.261 1.00017.06ANISOU 1659 O PRO 241 1698 1946 2838 17 -254 146ATOM 1660 CB PRO 241 17.689 11.462 53.619 1.00016.63ANISOU 1660 CB PRO 241 2162 1657 2501 -460-487 55ATOM 1661 CG PRO 241 17.138 12.651 52.826 1.00016.56ANISOU 1661 CG PRO 241 2433 1601 2258 -367-274 31ATOM 1662 CD PRO 241 17.164 12.140 51.409 1.00014.92ANISOU 1662 CD PRO 241 1841 1490 2339 -215-186 -66ATOM 1663 N ARG 242 15.740 9.04954.544 1.00015.74ANISOU 1663 N ARG 242 1914 1853 2212 -381-308 204ATOM 1664 CA ARG 242 14.574 8.77255.376 1.00015.50ANISOU 1664 CA ARG 242 1955 1863 2073 -236-291 180ATOM 1665 C ARG 242 14.406 9.84156.437 1.00016.60ANISOU 1665 C ARG 242 1889 2011 2407 -120-411 -51ATOM 1666 O ARG 242 15.372 10.416 56.994 1.00018.31ANISOU 1666 O ARG 242 2041 2186 2732 -216-559 -180ATOM 1667 CB ARG 242 14.728 7.41956.085 1.00018.38ANISOU 1667 CB ARG 242 2920 1810 2253 -486-391 269ATOM 1668 CG ARG 242 14.564 6.27355.094 1.00018.42ANISOU 1668 CG ARG 242 2372 1873 2755 -88 162-155ATOM 1669 CD ARG 242 14.854 4.93555.796 1.00023.07ANISOU 1669 CD ARG 242 3380 2022 3366 470 -483 -217ATOM 1670 NE ARG 242 16.334 4.95455.991 1.00026.69ANISOU 1670 NE ARG 242 3498 2727 3916 444 -829 47ATOM 1671 CZ ARG 242 16.941 3.92156.584 1.00027.19ANISOU 1671 CZ ARG 242 3166 2879 4284 -297-1143 802ATOM 1672 NH1 ARG 242 16.157 2.91356.989 1.00033.14ANISOU 1672 NH1 ARG 242 3810 3235 5546 -316528726ATOM 1673 NH2 ARG 242 18.241 3.88956.779 1.00031.13ANISOU 1673 NH2 ARG 242 3043 2925 5859 227 -769 484ATOM 1674 N HIS 243 13.188 10.057 56.872 1.00017.55ANISOU 1674 N HIS 243 1979 2233 2457 -165-173 -74ATOM 1675 CA HIS 243 12.913 11.050 57.914 1.00017.84ANISOU 1675 CA HIS 243 2186 2139 2452 -260-123 -75ATOM 1676 C HIS 243 11.644 10.627 58.643 1.00017.52ANISOU 1676 C HIS 243 2102 2084 2470 -248-164 -325ATOM 1677 O HIS 243 10.870 9.80358.132 1.00020.23ANISOU 1677 O HIS 243 2226 2593 2868 -551-323 -392ATOM 1678 CB HIS 243 12.865 12.456 57.324 1.00019.74ANISOU 1678 CB HIS 243 277022482482-188 -106 83ATOM 1679 CG HIS 243 11.922 12.630 56.187 1.000 22.60ANISOU 1679 CG HIS 243 344925132624164-382 0ATOM 1680 ND1 HIS 243 12.209 12.299 54.879 1.000 25.87ANISOU 1680 ND1 HIS 243 478025752473-609 -403 53ATOM 1681 CD2 HIS 243 10.633 13.034 56.172 1.000 29.11ANISOU 1681 CD2 HIS 243 322044903348121-421 1630ATOM 1682 CE1 HIS 243 11.182 12.573 54.109 1.000 32.92ANISOU 1682 CE1 HIS 243 583536723001-1102 -1367 689ATOM 1683 NE2 HIS 243 10.214 13.012 54.875 1.000 36.95ANISOU 1683 NE2 HIS 243 5719420141191019 -2016 987ATOM 1684 N HIS 244 11.437 11.194 59.831 1.000 18.87ANISOU 1684 N HIS 244 252324772171-88-141 -117ATOM 1685 CA HIS 244 10.302 10.801 60.649 1.000 20.83ANISOU 1685 CA HIS 244 280224852628171251272ATOM 1686 C HIS 244 9.927 11.968 61.551 1.000 20.33ANISOU 1686 C HIS 244 180329692953-31-78-273ATOM 1687 O HIS 244 10.482 13.073 61.510 1.000 21.71ANISOU 1687 O HIS 244 205734182774-535 145-853ATOM 1688 CB HIS 244 10.714 9.55761.468 1.000 24.38ANISOU 1688 CB HIS 244 406626442553-76-390 441ATOM 1689 CG HIS 244 11.859 9.72562.423 1.000 28.34ANISOU 1689 CG HIS 244 415834983113696-727 -89ATOM 1690 ND1 HIS 244 13.132 9.20562.268 1.000 32.35ANISOU 1690 ND1 HIS 244 401244713808548-485 -850ATOM 1691 CD2 HIS 244 11.928 10.391 63.609 1.000 25.21ANISOU 1691 CD2 HIS 244 293741372505-373 45 219ATOM 1692 CE1 HIS 244 13.887 9.53163.312 1.000 31.71ANISOU 1692 CE1 HIS 244 4157427736131224 -749 -518ATOM 1693 NE2 HIS 244 13.146 10.263 64.150 1.000 24.52ANISOU 1693 NE2 HIS 244 31653517263394 -82492ATOM 1694 N VAL 245 8.890 11.687 62.349 1.000 23.87ANISOU 1694 N VAL 245 262731193322-251 531-310ATOM 1695 CA VAL 245 8.473 12.691 63.349 1.000 24.85ANISOU 1695 CA VAL 245 278537702888481149-293ATOM 1696 C VAL 245 8.624 12.079 64.735 1.000 26.03ANISOU 1696 C VAL 245 322035583112-289 17989ATOM 1697 O VAL 245 8.023 11.025 64.969 1.000 27.98ANISOU 1697 O VAL 245 31203085442842 295-59ATOM 1698 CB VAL 245 7.020 13.114 63.099 1.000 26.02ANISOU 1698 CB VAL 245 26213489377794 -103 -569ATOM 1699 CG1 VAL 245 6.586 14.114 64.161 1.000 28.06ANISOU 1699 CG1 VAL 245 271733304614159746-485ATOM 1700 CG2 VAL 245 6.927 13.705 61.680 1.000 30.51ANISOU 1700 CG2 VAL 245 3564380942201264 -305 -33ATOM 1701 N ALA 246 9.399 12.696 65.603 1.000 28.08ANISOU 1701 N ALA 246 433837872543-850 250254ATOM 1702 CA ALA 246 9.567 12.316 67.003 1.000 27.45ANISOU 1702 CA ALA 246 426333602707292275373ATOM 1703 C ALA 246 8.356 12.740 67.833 1.000 32.68ANISOU 1703 C ALA 246 49154473303198 880197ATOM 1704 O ALA 246 7.774 13.791 67.563 1.000 29.54ANISOU 1704 O ALA 246 352242833417-224 875-329ATOM 1705 CB ALA 246 10.819 13.010 67.542 1.000 30.33ANISOU 1705 CB ALA 246 456439493011615-221 -422ATOM 1706 N ALA 247 8.048 11.958 68.849 1.000 34.09ANISOU 1706 N ALA 247 448351563311-1190 466393ATOM 1707 CA ALA 247 7.036 12.190 69.859 1.000 34.23ANISOU 1707 CA ALA 247 418856273189-1215 315515ATOM 1708 C ALA 247 7.609 12.910 71.081 1.000 33.31ANISOU 1708 C ALA 247 541946842555249-506 1147ATOM 1709 O ALA 247 8.733 12.708 71.523 1.000 38.23ANISOU 1709 O ALA 247 578744784259-378 -1519 1230ATOM 1710 CB ALA 247 6.383 10.881 70.314 1.000 47.11ANISOU 1710 CB ALA 247 837467262801-2800 1464 686ATOM 1711 N PRO 248 6.817 13.851 71.577 1.000 42.28ANISOU 1711 N PRO 248 577154584836-300 933 -97ATOM 1712 CA PRO 248 7.256 14.581 72.773 1.000 44.85ANISOU 1712 CA PRO 248 756854783996-645 1413 214ATOM 1713 C PRO 248 7.161 13.618 73.948 1.000 49.25ANISOU 1713 C PRO 248 797856605075-1446 552 985ATOM 1714 O PRO 248 6.251 12.794 74.014 1.000 45.48ANISOU 1714 O PRO 248 765153914237-1127 2573 -796ATOM 1715 CB PRO 248 6.196 15.674 72.897 1.000 49.75ANISOU 1715 C8 PRO 248 856348165523-513 1238 -138ATOM 1716 CG PRO 248 4.973 15.053 72.299 1.000 50.89ANISOU 1716 CG PRO 248 722855646545-108 2210 -1064ATOM 1717 CD PRO 248 5.489 14.272 71.114 1.000 44.69ANISOU 1717 CD PRO 248 639545796006937953 -577ATOM 1718 N ARG 249 8.109 13.683 74.883 1.000 48.76ANISOU 1718 N ARG 249 914163413045-1317 1069 -477ATOM 1719 CA ARG 249 7.865 12.783 76.024 1.000 55.51ANISOU 1719 CA ARG 249 10023 69144156-1098 895 566ATOM 1720 C ARG 249 6.844 13.466 76.916 1.000 46.09ANISOU 1720 C ARG 249 556183823568-2484 -71237ATOM 1721 O ARG 249 6.244 12.915 77.831 1.000 56.25ANISOU 1721 O ARG 249 757263687433-377 1799 3995ATOM 1722 CB ARG 249 9.177 12.459 76.721 1.000 55.24ANISOU 1722 CB ARG 249 8950771543267052864 1270ATOM 1723 CG ARG 249 9.915 11.278 76.110 1.000 71.04ANISOU 1723 CG ARG 249 12881 733067791135 3707 622ATOM 1724 CD ARG 249 10.403 10.303 77.165 1.000 72.89ANISOU 1724 CD ARG 249 11721 799179842171 2723 409ATOM 1725 NE ARG 249 11.124 9.162 76.580 1.000 70.73ANISOU 1725 NE ARG 249 8627997782712362 2650 -266ATOM 1726 CZ ARG 249 12.039 8.493 77.282 1.000 72.71ANISOU 1726 CZ ARG 249 10269 941779422304 2153 133ATOM 1727 NH1 ARG 249 12.297 8.893 78.521 1.000 89.50ANISOU 1727 NH1 ARG 249 22286 616155592015 1622 3874ATOM 1728 NH2 ARG 249 12.682 7.462 76.761 1.000 67.68ANISOU 1728 NH2 ARG 249 535810062 10295 1004 3886 221ATOM 1729 N ALA 254 1.981 18.918 75.430 1.000 85.24ANISOU 1729 N ALA 254 15501 79228964-4581 -1437 2347ATOM 1730 CA ALA 254 2.287 20.081 76.257 1.000 76.08ANISOU 1730 CA ALA 254 12510 81108286-3993 1617 1592ATOM 1731 C ALA 254 2.943 21.216 75.489 1.000 60.91ANISOU 1731 C ALA 254 838357199040-506 2886 1312ATOM 1732 O ALA 254 4.174 21.309 75.487 1.000 72.37ANISOU 1732 O ALA 254 8056810911332 1602 4553 3381ATOM 1733 CB ALA 254 3.264 19.667 77.351 1.000 60.48ANISOU 1733 CB ALA 254 12589 72623131-866 4570 -1112ATOM 1734 N GLY 255 2.200 22.108 74.846 1.000 54.40ANISOU 1734 N GLY 255 8029545171905942922 -940ATOM 1735 CA GLY 255 2.880 23.171 74.098 1.000 40.05ANISOU 1735 CA GLY 255 5181457054651424 836 -921ATOM 1736 C GLY 255 3.640 22.565 72.921 1.000 38.82ANISOU 1736 C GLY 255 422747725749557702 -1561ATOM 1737 O GLY 255 4.580 23.163 72.398 1.000 39.96ANISOU 1737 O GLY 255 297864915715-128 -136 -2226ATOM 1738 N SER 256 3.164 21.387 72.509 1.000 37.29ANISOU 1738 N SER 256 50474594452738911-853ATOM 1739 CA SER 256 3.738 20.606 71.429 1.000 35.71ANISOU 1739 CA SER 256 4737 4533 4299 560-501 -919ATOM 1740 CSER 256 2.983 20.742 70.118 1.000 34.93ANISOU 1740 CSER 256 4584 4669 4019 -98-85 91ATOM 1741 OSER 256 3.251 20.000 69.162 1.000 33.92ANISOU 1741 OSER 256 3575 6107 3207 503304 377ATOM 1742 CB SER 256 3.845 19.136 71.853 1.000 30.17ANISOU 1742 CB SER 256 3125 4830 3509 624212 -492ATOM 1743 OG SER 256 2.688 18.752 72.601 1.000 61.15ANISOU 1743 OG SER 256 2987 8497 117504511943 2630ATOM 1744 NSER 257 2.065 21.700 70.030 1.000 35.54ANISOU 1744 NSER 257 4037 5989 3479 347242 -86ATOM 1745 CA SER 257 1.379 21.993 68.767 1.000 30.95ANISOU 1745 CA SER 257 2824 5827 3109 170672 -509ATOM 1746 CSER 257 2.378 22.538 67.760 1.000 30.63ANISOU 1746 CSER 257 3181 5524 2934 -476 765 -1297ATOM 1747 OSER 257 3.359 23.159 68.199 1.000 34.70ANISOU 1747 OSER 257 3500 6070 3616 -829 603 -1516ATOM 1748 CB SER 257 0.331 23.088 69.036 1.000 38.70ANISOU 1748 CB SER 257 3085 6518 5103 7961381 435ATOM 1749 OG SER 257 0.801 24.361 68.601 1.000 65.12ANISOU 1749 OG SER 257 8002 5175 11565-999 -3375 383ATOM 1750 NARG 258 2.119 22.384 66.471 1.000 30.51ANISOU 1750 NARG 258 3668 5068 2855 -332 677 -995ATOM 1751 CA ARG 258 2.997 22.819 65.396 1.000 28.15ANISOU 1751 CA ARG 258 3100 4620 2976 -106 358 -544ATOM 1752 CARG 258 2.198 22.913 64.096 1.000 25.64ANISOU 1752 CARG 258 3488 3381 2872 -676 273 -904ATOM 1753 OARG 258 1.132 22.294 63.981 1.000 24.93ANISOU 1753 OARG 258 3162 3240 3070 -441 478 -560ATOM 1754 CB ARG 258 4.175 21.873 65.154 1.000 27.21ANISOU 1754 CB ARG 258 3158 4041 3141 -446 313 -1352ATOM 1755 CG ARG 258 3.861 20.508 64.570 1.000 30.90ANISOU 1755 CG ARG 258 4782 3429 3531 -737 -738 -389ATOM 1756 CD ARG 258 5.039 19.537 64.769 1.000 36.65ANISOU 1756 CD ARG 258 5937 3466 4523 106477 306ATOM 1757 NE ARG 258 4.597 18.176 64.411 1.000 32.42ANISOU 1757 NE ARG 258 3372 3858 5089 -85-274 528ATOM 1758 CZ ARG 258 4.633 17.777 63.143 1.000 37.32ANISOU 1758 CZ ARG 258 5670 2958 5553 155680 43ATOM 1759 NH1 ARG 258 5.075 18.622 62.217 1.000 29.98ANISOU 1759 NH1 ARG 258 3077 3435 4881 -150 -211 -103ATOM 760 NH2 ARG 258 4.210 16.566 62.824 1.000 38.66ANISOU 1760 NH2 ARG 258 5812 3151 5724 -190 -1632 865ATOM 1761 NTHR 259 2.806 23.572 63.120 1.000 23.62ANISOU 1761 NTHR 259 2625 3578 2771 -519 315 -1037ATOM 1762 CA THR 259 2.337 23.482 61.730 1.000 21.97ANISOU 1762 CA THR 259 2614 2934 2800 -36247 -1041ATOM 1763 CTHR 259 3.528 23.197 60.808 1.000 19.76ANISOU 1763 CTHR 259 2257 2663 2587 -3821-699ATOM 1764 OTHR 259 4.698 23.411 61.159 1.000 21.13ANISOU 1764 OTHR 259 2464 3096 2468 -495 -10 -286ATOM 1765 CB THR 259 1.682 24.793 61.278 1.000 24.04ANISOU 1765 CB THR 259 2125 3084 3927 70-17-1229ATOM 1766 OG1 THR 259 2.697 25.790 61.041 1.000 23.14ANISOU 1766 OG1 THR 259 2297 2848 3648 196-142 -829ATOM 1767 CG2 THR 259 0.760 25.408 62.331 1.000 25.17ANISOU 1767 CG2 THR 259 2941 3229 3393 726264 -136ATOM 1768 NSER 260 3.234 22.706 59.600 1.000 20.41ANISOU 1768 NSER 260 2386 2762 2609 -6174-806ATOM 1769 CA SER 260 4.225 22.515 58.551 1.000 19.33ANISOU 1769 CA SER 260 2488 2459 2399 1928 -344ATOM 1770 C SER 260 3.587 22.871 57.210 1.000 18.78ANISOU 1770 C SER 260 199625442595-379 -264 -311ATOM 1771 O SER 260 2.375 22.758 56.988 1.000 21.20ANISOU 1771 O SER 260 191724483689-75-269 -573ATOM 1772 CB SER 260 4.738 21.076 58.480 1.000 20.28ANISOU 1772 CB SER 260 249124582755160-101 -495ATOM 1773 OG SER 260 3.656 20.197 58.227 1.000 22.70ANISOU 1773 OG SER 260 275825743294-113 -284 -169ATOM 1774 N SER 261 4.474 23.329 56.330 1.000 18.79ANISOU 1774 N SER 261 218922152737-55-92 35ATOM 1775 CA SER 261 4.148 23.585 54.929 1.000 16.88ANISOU 1775 CA SER 261 20741718262222 -117 -404ATOM 1776 C SER 261 5.066 22.672 54.106 1.000 17.25ANISOU 1776 C SER 261 172018333000101-350 -491ATOM 1777 O SER 261 6.272 22.876 54.173 1.000 19.96ANISOU 1777 O SER 261 17122417345650-483 -781ATOM 1778 CB SER 261 4.471 25.028 54.503 1.000 19.95ANISOU 1778 CB SER 261 290316753002164-113 -135ATOM 1779 OG SER 261 4.404 25.127 53.107 1.000 35.64ANISOU 1779 OG SER 261 543548143293-1089 -766 1263ATOM 1780 N VAL 262 4.467 21.722 53.435 1.000 15.56ANISOU 1780 N VAL 262 175120212140-75-40 -436ATOM 1781 CA VAL 262 5.247 20.713 52.711 1.000 15.41ANISOU 1781 CA VAL 262 1871193820484321-196ATOM 1782 C VAL 262 4.914 20.874 51.242 1.000 14.05ANISOU 1782 C VAL 262 146017842095-1329 -144ATOM 1783 O VAL 262 3.759 20.712 50.844 1.000 15.45ANISOU 1783 O VAL 262 148819002481-175 -94 -191ATOM 1784 CB VAL 262 4.902 19.307 53.253 1.000 16.87ANISOU 1784 CB VAL 262 214420052260165-164 23ATOM 1785 CG1 VAL 262 5.567 18.275 52.364 1.000 20.01ANISOU 1785 CG1 VAL 262 2433200631654 -191 -637ATOM 1786 CG2 VAL 262 5.335 19.200 54.715 1.000 18.63ANISOU 1786 CG2 VAL 262 239022422446147-397 175ATOM 1787 N PHE 263 5.894 21.163 50.412 1.000 13.73ANISOU 1787 N PHE 263 1497157321485 -64 186ATOM 1788 CA PHE 263 5.762 21.411 48.994 1.000 13.04ANISOU 1788 CA PHE 263 165411962105-12 -193 113ATOM 1789 C PHE 263 6.479 20.253 8.284 1.000 13.56ANISOU 1789 C PHE 263 143213512370-175 -98 -87ATOM 1790 O PHE 263 7.732 20.177 48.281 1.000 13.83ANISOU 1790 O PHE 263 141514372403-82-299 -104ATOM 1791 CB PHE 263 6.364 22.770 48.594 1.000 13.50ANISOU 1791 CB PHE 263 165813742098-295 -97 34ATOM 1792 CG PHE 263 6.062 23.148 47.135 1.000 13.34ANISOU 1792 CG PHE 263 161613582096-159 -111 82ATOM 1793 CD1 PHE 263 6.750 22.635 46.051 1.000 14.95ANISOU 1793 CD1 PHE 263 197715472156-354 -131 -384ATOM 1794 CD2 PHE 263 5.005 24.048 46.883 1.000 15.37ANISOU 1794 CD2 PHE 263 154915572735-139 -264 303ATOM 1795 CE1 PHE 263 6.468 22.945 44.720 1.000 14.58ANISOU 1795 CE1 PHE 263 172116212196-242 71 -144ATOM 1796 CE2 PHE 263 4.703 24.366 45.566 1.000 14.71ANISOU 1796 CE2 PHE 263 148214282680-20-261 137ATOM 1797 CZ PHE 263 5.383 23.809 44.479 1.000 16.55ANISOU 1797 CZ PHE 263 193514922862-152 29 14ATOM 1798 N PHE 264 5.721 19.405 47.588 1.000 12.07ANISOU 1798 N PHE 264 127713431967-66-49 19ATOM 1799 CA PHE 264 6.267 18.328 46.769 1.000 11.90ANISOU 1799 CA PHE 264 117712892058-129 34 -21ATOM 1800 C PHE 264 6.440 18.775 45.314 1.000 11.76ANISOU 1800 C PHE 264 12061258 2004 -121 -42 8ATOM 1801 O PHE 264 5.418 19.097 44.683 1.000 12.55ANISOU 1801 O PHE 264 11651473 2133 -77-120 46ATOM 1802 CB PHE 264 5.346 17.099 46.773 1.000 12.39ANISOU 1802 CB PHE 264 11011498 2110 -304 -42 63ATOM 1803 CG PHE 264 5.022 16.558 48.150 1.000 13.97ANISOU 1803 CG PHE 264 16471465 2197 -290 13 121ATOM 1804 CD1 PHE 264 5.960 15.848 48.852 1.000 17.07ANISOU 1804 CD1 PHE 264 20391976 2471 -422 -410 497ATOM 1805 CD2 PHE 264 3.747 16.679 48.668 1.000 17.41ANISOU 1805 CD2 PHE 264 18352359 2419 -440 433 112ATOM 1806 CE1 PHE 264 5.661 15.247 50.053 1.000 20.59ANISOU 1806 CE1 PHE 264 26162710 2496 -556 -425 725ATOM 1807 CE2 PHE 264 3.458 16.133 49.906 1.000 22.51ANISOU 1807 CE2 PHE 264 21514047 2355 -787 106 553ATOM 1808 CZ PHE 264 4.386 15.350 50.562 1.000 20.88ANISOU 1808 CZ PHE 264 28892376 2669 -936 -22 306ATOM 1809 N LEU 265 7.676 18.756 44.811 1.000 11.81ANISOU 1809 N LEU 265 11921248 2047 -3747 19ATOM 1810 CA LEU 265 7.900 19.000 43.374 1.000 12.01ANISOU 1810 CA LEU 265 12641269 2028 -223 16 -63ATOM 1811 C LEU 265 7.915 17.617 42.703 1.000 12.10ANISOU 1811 C LEU 265 12661298 2033 -117 -81 3ATOM 1812 O LEU 265 8.842 16.834 42.915 1.000 12.93ANISOU 1812 O LEU 265 13671283 2260 -107 -152 44ATOM 1813 CB LEU 265 9.246 19.730 43.156 1.000 12.59ANISOU 1813 CB LEU 265 13991364 2019 -257 57 -9ATOM 1814 CG LEU 265 9.500 20.124 41.709 1.000 12.19ANISOU 1814 CG LEU 265 11681399 2066 -292 -248 302ATOM 1815 CD1 LEU 265 8.620 21.314 41.318 1.000 13.29ANISOU 1815 CD1 LEU 265 15181546 1984 843619ATOM 1816 CD2 LEU 265 10.971 20.458 41.449 1.000 13.14ANISOU 1816 CD2 LEU 265 12041593 2197 -234 41 -20ATOM 1817 N ARG 266 6.842 17.249 41.996 1.000 12.06ANISOU 1817 N ARG 266 14121127 2043 -220 -190 45ATOM 1818 CA ARG 266 6.586 15.913 41.488 1.000 12.07ANISOU 1818 CA ARG 266 13721201 2012 -258 0 80ATOM 1819 C ARG 266 6.619 15.965 39.972 1.000 11.75ANISOU 1819 C ARG 266 12031315 1948 29-267 142ATOM 1820 O ARG 266 6.032 16.860 39.396 1.000 13.06ANISOU 1820 O ARG 266 14301318 2214 5 -173 281ATOM 1821 CB ARG 266 5.243 15.370 41.994 1.000 12.95ANISOU 1821 CB ARG 266 11421477 2302 -189 43 -33ATOM 1822 CG ARG 266 5.036 15.606 43.488 1.000 13.80ANISOU 1822 CG ARG 266 13511686 2207 -159 66 -115ATOM 1823 CD ARG 266 3.723 15.041 43.993 1.000 12.70ANISOU 1823 CD ARG 266 13691362 2094 66-22 84ATOM 1824 NE ARG 266 2.581 15.648 43.281 1.000 12.97ANISOU 1824 NE ARG 266 13431155 2428 52-165 -157ATOM 1825 CZ ARG 266 1.304 15.281 43.500 1.000 11.34ANISOU 1825 CZ ARG 266 14321009 1869 45-149 -103ATOM 1826 NH1 ARG 266 0.995 14.414 44.476 1.000 13.39ANISOU 1826 NH1 ARG 266 18021165 2119 -11-38 72ATOM 1827 NH2 ARG 266 0.305 15.821 42.826 1.000 12.55ANISOU 1827 NH2 ARG 266 14901067 2210 125-357 -159ATOM 1828 N PRO 267 7.237 14.951 39.357 1.000 12.74ANISOU 1828 N PRO 267 14181394 2030 16-146 108ATOM 1829 CA PRO 267 7.298 14.947 37.887 1.000 13.88ANISOU 1829 CA PRO 267 14421786 2047 167-125 -84ATOM 1830 C PRO 267 5.957 14.722 37.222 1.000 12.61ANISOU 1830 C PRO 267 14131508 1868 -64427ATOM 1831 O PRO 267 4.998 14.155 37.772 1.000 13.60ANISOU 1831 O PRO 267 16481355 2164-160 118 93ATOM 1832 CB PRO 267 8.238 13.761 37.599 1.000 15.30ANISOU 1832 CB PRO 267 14351740 2637115-28 -169ATOM 1833 CG PRO 267 8.033 12.846 38.764 1.000 15.82ANISOU 1833 CG PRO 267 18851804 2324381-270 -197ATOM 1834 CD PRO 267 7.872 13.746 39.965 1.000 14.73ANISOU 1834 CD PRO 267 18031356 2438311-666 -205ATOM 1835 N ASN 268 5.933 15.051 35.939 1.000 13.27ANISOU 1835 N ASN 268 16011665 1777-126 -43 -127ATOM 1836 CA ASN 268 4.800 14.709 35.073 1.000 13.72ANISOU 1836 CA ASN 268 17931401 2018-214 -236 -71ATOM 1837 C ASN 268 4.723 13.192 34.875 1.000 13.14ANISOU 1837 C ASN 268 14851350 2156-213 104 54ATOM 1838 O ASN 268 5.702 12.467 34.934 1.000 13.90ANISOU 1838 O ASN 268 16981416 2167-91123 -36ATOM 1839 CB ASN 268 4.997 15.338 33.690 1.000 15.74ANISOU 1839 CB ASN 268 25971369 2016-66-437 135ATOM 1840 CG ASN 268 5.011 16.862 33.811 1.000 15.41ANISOU 1840 CG ASN 268 22551439 2162-17-184 47ATOM 1841 OD1 ASN 268 4.069 17.454 34.352 1.000 17.75ANISOU 1841 OD1 ASN 268 25731686 24874291-98ATOM 1842 ND2 ASN 268 6.066 17.503 33.319 1.000 16.61ANISOU 1842 ND2 ASN 268 24081355 2546-50-57 142ATOM 1843 N ALA 269 3.531 12.712 34.594 1.000 13.99ANISOU 1843 N ALA 269 16771467 2172-356 -65 170ATOM 1844 CA ALA 269 3.278 11.286 34.353 1.000 13.42ANISOU 1844 CA ALA 269 14591405 2234-208 -118 107ATOM 1845 C ALA 269 4.182 10.729 33.252 1.000 13.93ANISOU 1845 C ALA 269 12891538 2466-168 -5 153ATOM 1846 O ALA 269 4.581 9.550 33.318 1.000 14.97ANISOU 1846 O ALA 269 17181476 2494-143 112 86ATOM 1847 CB ALA 269 1.806 11.051 34.008 1.000 13.76ANISOU 1847 CB ALA 269 13001474 2454-60-61 123ATOM 1848 N ASP 270 4.482 11.541 32.251 1.000 14.38ANISOU 1848 N ASP 270 16881476 2300-151 30 -5ATOM 1849 CA ASP 270 5.247 11.079 31.098 1.000 14.83ANISOU 1849 CA ASP 270 17471693 2194-99-42 68ATOM 1850 C ASP 270 6.749 11.287 31.227 1.000 15.68ANISOU 1850 C ASP 270 17141886 2357-224 143 86ATOM 1851 O ASP 270 7.483 11.008 30.255 1.000 17.12ANISOU 1851 O ASP 270 19522354 2200-80139 226ATOM 1852 CB ASP 270 4.718 11.681 29.800 1.000 17.67ANISOU 1852 CB ASP 270 24611966 2288-75-319 126ATOM 1853 CG ASP 270 4.968 13.168 29.649 1.000 18.22ANISOU 1853 CG ASP 270 22842024 2613-88-80 474ATOM 1854 OD1 ASP 270 5.386 13.826 30.607 1.000 20.55ANISOU 1854 OD1 ASP 270 34241541 2844-47-287 425ATOM 1855 OD2 ASP 270 4.646 13.698 28.552 1.000 23.06ANISOU 1855 OD2 ASP 270 33172727 2719-49-136 812ATOM 1856 N PHE 271 7.221 11.668 32.413 1.000 13.93ANISOU 1856 N PHE 271 15561318 241797 31 41ATOM 1857 CA PHE 271 8.671 11.723 32.644 1.000 14.41ANISOU 1857 CA PHE 271 16241430 242311029 263ATOM 1858 C PHE 271 9.275 10.349 32.325 1.000 13.31ANISOU 1858 C PHE 271 14021430 2225-3028 218ATOM 1859 O PHE 271 8.790 9.340 32.870 1.000 14.91ANISOU 1859 O PHE 271 19001374 2392-26240 192ATOM 1860 CB PHE 271 8.942 12.146 34.098 1.000 15.57ANISOU 1860 CB PHE 271 17001721 2495-66-36 9ATOM 1861 CG PHE 271 10.386 11.791 34.516 1.000 14.56ANISOU 1861 CG PHE 271 17291320 2485 -152 34 -124ATOM 1862 CD1 PHE 271 11.460 12.369 33.814 1.000 17.76ANISOU 1862 CD1 PHE 271 17141581 3452 -235 393 -249ATOM 1863 CD2 PHE 271 10.698 10.972 35.570 1.000 18.04ANISOU 1863 CD2 PHE 271 21821543 3130 -95-540 172ATOM 1864 CE1 PHE 271 12.786 12.092 34.166 1.000 17.54ANISOU 1864 CE1 PHE 271 18381700 3128 -291 114 -50ATOM 1865 CE2 PHE 271 11.997 10.609 35.899 1.000 18.84ANISOU 1865 CE2 PHE 271 19351646 3578 -392 -396 425ATOM 1866 CZ PHE 271 13.039 11.154 35.162 1.000 17.25ANISOU 1866 CZ PHE 271 24441697 2415 -486 -19 -394ATOM 1867 N THR 272 10.278 10.298 31.453 1.000 13.78ANISOU 1867 N THR 272 15141641 2083 30 19 154ATOM 1868 CA THR 272 10.811 9.046 30.938 1.000 13.99ANISOU 1868 CA THR 272 15511660 2105 -9983 67ATOM 1869 C THR 272 12.246 8.841 31.410 1.000 14.71ANISOU 1869 C THR 272 15981549 2441 -3108 357ATOM 1870 O THR 272 13.046 9.808 31.424 1.000 16.23ANISOU 1870 O THR 272 16461742 2780 -246 5185ATOM 1871 CB THR 272 10.751 9.117 29.388 1.000 16.27ANISOU 1871 CB THR 272 18562205 2119 191125 8ATOM 1872 OG1 THR 272 9.341 9.221 29.032 1.000 17.99ANISOU 1872 OG1 THR 272 19962473 2368 64-190 264ATOM 1873 CG2 THR 272 11.249 7.856 28.723 1.000 17.94ANISOU 1873 CG2 THR 272 24232167 2227 173177 -94ATOM 1874 N PHE 273 12.567 7.600 31.743 1.000 14.91ANISOU 1874 N PHE 273 16441521 2499 92238 218ATOM 1875 CA PHE 273 13.894 7.253 32.254 1.000 15.16ANISOU 1875 CA PHE 273 16021813 2345 296277 55ATOM 1876 C PHE 273 14.350 5.899 31.724 1.000 14.69ANISOU 1876 C PHE 273 14081647 2528 24479 178ATOM 1877 O PHE 273 13.541 5.086 31.262 1.000 15.91ANISOU 1877 O PHE 273 17381767 2541 -115 450 119ATOM 1878 CB PHE 273 13.899 7.301 33.769 1.000 15.77ANISOU 1878 CB PHE 273 17581921 2314 -344 286 123ATOM 1879 CG PHE 273 12.931 6.336 34.424 1.000 14.54ANISOU 1879 CG PHE 273 13901726 2410 -95-11 195ATOM 1880 CD1 PHE 273 11.601 6.743 34.655 1.000 16.64ANISOU 1880 CD1 PHE 273 14572343 2521 -24308 362ATOM 1881 CD2 PHE 273 13.295 5.038 34.721 1.000 15.23ANISOU 1881 CD2 PHE 273 18631624 2300 -110 91 136ATOM 1882 CE1 PHE 273 10.719 5.848 35.259 1.000 16.10ANISOU 1882 CE1 PHE 273 15932158 2365 -162 292 122ATOM 1883 CE2 PHE 273 12.419 4.148 35.354 1.000 16.01ANISOU 1883 CE2 PHE 273 19041980 2198 -139 285 181ATOM 1884 CZ PHE 273 11.109 4.559 35.548 1.000 15.18ANISOU 1884 CZ PHE 273 18432001 1925 -141 73 -227ATOM 1885 N SER 274 15.634 5.612 31.926 1.000 15.31ANISOU 1885 N SER 274 15591940 2317 361383 247ATOM 1886 CA SER 274 16.221 4.318 31.518 1.000 15.37ANISOU 1886 CA SER 274 14761723 2642 32 557 156ATOM 1887 C SER 274 15.953 3.284 32.588 1.000 14.67ANISOU 1887 C SER 274 973 18772726 -113265 302ATOM 1888 O SER 274 16.310 3.476 33.770 1.000 15.98ANISOU 1888 O SER 274 16681677 2728 126143 193ATOM 1889 CB SER 274 17.742 4.556 31.356 1.000 17.41ANISOU 1889 CB SER 274 14872019 3112 235945 725ATOM 1890 OG SER 274 18.362 3.280 31.334 1.000 18.03ANISOU 1890 OG SER 274 18391961 3052 293840 188ATOM 1891 N VAL 275 15.395 2.133 32.182 1.000 15.58ANISOU 1891 N VAL 275 16461857 2417 -182 461 261ATOM 1892 CA VAL 275 15.158 1.033 33.137 1.000 15.65ANISOU 1892 CA VAL 275 16811800 2466 -180 261 265ATOM 1893 CVAL 275 16.454 0.445 33.659 1.000 15.33ANISOU 1893 CVAL 275 18051881 2139 116392 -45ATOM 1894 OVAL 275 16.623 0.280 34.871 1.000 15.68ANISOU 1894 OVAL 275 20371655 2267 6 297 196ATOM 1895 CB VAL 275 14.227 -0.004 32.483 1.000 16.05ANISOU 1895 CB VAL 275 16351708 2755 -76405 21ATOM 1896 CG1 VAL 275 14.080 -1.186 33.426 1.000 17.04ANISOU 1896 CG1 VAL 275 20451688 2740 -211 230 15ATOM 1897 CG2 VAL 275 12.847 0.608 32.203 1.000 18.45ANISOU 1897 CG2 VAL 275 16502432 2928 -57135 269ATOM 1898 NPRO 276 17.437 0.093 32.844 1.000 16.21ANISOU 1898 NPRO 276 19271700 2532 97 589 36ATOM 1899 CA PRO 276 18.707 -0.434 33.399 1.000 18.10ANISOU 1899 CA PRO 276 17362115 3025 147616 -93ATOM 1900 CPRO 276 19.382 0.541 34.321 1.000 17.52ANISOU 1900 CPRO 276 19981961 2697 97 469 239ATOM 1901 OPRO 276 19.963 0.171 35.348 1.000 19.66ANISOU 1901 OPRO 276 20152409 3047 24 280 468ATOM 1902 CB PRO 276 19.590 -0.796 32.214 1.000 20.80ANISOU 1902 CB PRO 276 20942687 3121 306771 -249ATOM 1903 CG PRO 276 18.852 -0.390 30.999 1.000 21.57ANISOU 1903 CG PRO 276 20513098 3046 340802 -288ATOM 1904 CD PRO 276 17.446 -0.021 31.368 1.000 18.17ANISOU 1904 CD PRO 276 20532306 2546 179832 -318ATOM 1905 NLEU 277 19.325 1.845 34.027 1.000 17.09ANISOU 1905 NLEU 277 15711898 3025 230511 107ATOM 1906 CA LEU 277 19.962 2.802 34.940 1.000 19.34ANISOU 1906 CA LEU 277 20352141 3171 -219 218 262ATOM 1907 CLEU 277 19.214 2.858 36.249 1.000 18.34ANISOU 1907 CLEU 277 19631958 3049 -33-3 -38ATOM 1908 OLEU 277 19.815 2.957 37.319 1.000 19.29ANISOU 1908 OLEU 277 24661710 3154 -271 -188 -2ATOM 1909 CB LEU 277 20.094 4.178 34.291 1.000 21.41ANISOU 1909 CB LEU 277 27392011 3383 1412287ATOM 1910 CG LEU 277 20.910 5.192 35.111 1.000 26.34ANISOU 1910 CG LEU 277 36622367 3978 -980 -547 944ATOM 1911 CD1 LEU 277 22.396 4.839 35.069 1.000 38.04ANISOU 1911 CD1 LEU 277 37643171 7518 -487 -2057 853ATOM 1912 CD2 LEU 277 20.708 6.607 34.631 1.000 31.98ANISOU 1912 CD2 LEU 277 40232018 6109 -366 508 732ATOM 1913 NALA 278 17.875 2.711 36.202 1.000 17.30ANISOU 1913 NALA 278 20151766 2793 74 218 115ATOM 1914 CA ALA 278 17.124 2.712 37.464 1.000 16.75ANISOU 1914 CA ALA 278 22001566 2600 216146 -2ATOM 1915 CALA 278 17.575 1.523 38.313 1.000 16.31ANISOU 1915 CALA 278 18491553 2794 -337 -196 107ATOM 1916 OALA 278 17.718 1.635 39.523 1.000 17.26ANISOU 1916 OALA 278 19631839 2754 -62-53 205ATOM 1917 CB ALA 278 15.642 2.622 37.177 1.000 17.55ANISOU 1917 CB ALA 278 21091880 2679 295195 -11ATOM 1918 NARG 279 17.724 0.362 37.696 1.000 17.07ANISOU 1918 NARG 279 23221399 2766 -178 26 308ATOM 1919 CA ARG 279 18.099 -0.829 38.473 1.000 16.93ANISOU 1919 CA ARG 279 23771734 2323 15-241 203ATOM 1920 CARG 279 19.477 -0.587 39.098 1.000 19.87ANISOU 1920 CARG 279 24912292 2766 -487 -384 543ATOM 1921 OARG 279 19.687 -0.974 40.234 1.000 33.04ANISOU 1921 OARG 279 36154823 4115 -1726 -1700 2603ATOM 1922 CB ARG 279 18.164 -2.042 37.517 1.000 20.04ANISOU 1922 CB ARG 279 2042 1609 3964 108-221 -305ATOM 1923 CG ARG 279 16.742-2.491 37.179 1.000 20.73ANISOU 1923 CG ARG 279 2152 2728 2997 -98-401 -351ATOM 1924 CD ARG 279 16.601-3.422 35.990 1.000 24.81ANISOU 1924 CD ARG 279 3213 2982 3231 -1 -507 -609ATOM 1925 NE ARG 279 17.575-4.484 36.195 1.000 27.50ANISOU 1925 NE ARG 279 4331 2656 3463 355-146 -181ATOM 1926 CZ ARG 279 17.301-5.725 36.620 1.000 41.33ANISOU 1926 CZ ARG 279 7720 2466 5519 -186 -454 -142ATOM 1927 NH1 ARG 279 16.024-6.012 36.866 1.000 40.58ANISOU 1927 NH1 ARG 279 8821 3012 3585 -1564 507 452ATOM 1928 NH2 ARG 279 18.200-6.688 36.807 1.000 53.27ANISOU 1928 NH2 ARG 279 9516 2227 8496 -127 -4607 -463ATOM 1929 N GLU 280 20.3900.119 38.424 1.000 19.68ANISOU 1929 N GLU 280 2172 2276 3028 84 324 136ATOM 1930 CA GLU 280 21.7480.334 38.948 1.000 20.28ANISOU 1930 CA GLU 280 2046 2274 3385 25 581 115ATOM 1931 C GLU 280 21.7051.257 40.182 1.000 20.67ANISOU 1931 C GLU 280 2334 1968 3552 -281 285 20ATOM 1932 O GLU 280 22.7231.079 40.908 1.000 26.81ANISOU 1932 O GLU 280 2659 3419 4107 -37-183 -87ATOM 1933 CB GLU 280 22.6511.029 37.926 1.000 24.69ANISOU 1933 CB GLU 280 2778 2558 4044 -351 1022 303ATOM 1934 CG GLU 280 22.9970.342 36.634 1.000 27.13ANISOU 1934 CG GLU 280 2605 4888 2816 596116 623ATOM 1935 CD GLU 280 23.8151.298 35.760 1.000 43.10ANISOU 1935 CD GLU 280 4693 7780 3903 -1328 1206 834ATOM 1936 OE1 GLU 280 24.5412.171 36.296 1.000 41.36ANISOU 1936 OE1 GLU 280 2666 6033 7015 27 1099 690ATOM 1937 OE2 GLU 280 23.7271.219 34.520 1.000 64.81ANISOU 1937 OE2 GLU 280 10844 10028 3751 -2356 1104 2134ATOM 1938 N CYS 281 20.7772.156 40.313 1.000 21.61ANISOU 1938 N CYS 281 2372 2240 3599 -211 532 -238ATOM 1939 CA CYS 281 20.4813.164 41.337 1.000 24.33ANISOU 1939 CA CYS 281 2114 2911 4219 -526 1121 -817ATOM 1940 C CYS 281 19.8582.568 42.585 1.000 27.11ANISOU 1940 C CYS 281 2492 3261 4546 -1608 1457 -1343ATOM 1941 O CYS 281 19.7893.161 43.685 1.000 19.19ANISOU 1941 O CYS 281 1997 2012 3282 -250 -326 135ATOM 1942 CB CYS 281 19.6324.438 40.795 1.000 22.02ANISOU 1942 CB CYS 281 1214 3088 4063 -286 100 -2108ATOM 1943 SG CYS 281 20.6395.092 39.444 1.000 53.41ANISOU 1943 SG CYS 281 10822 4742 4730 -3261 1316 45ATOM 1944 N GLY 282 19.3701.317 42.565 1.000 18.81ANISOU 1944 N GLY 282 1230 2224 3695 3 -149 -206ATOM 1945 CA GLY 282 18.6750.750 43.744 1.000 17.07ANISOU 1945 CA GLY 282 1544 1771 3171 31 -552 -168ATOM 1946 C GLY 282 17.1940.496 43.538 1.000 14.91ANISOU 1946 C GLY 282 1601 1645 2417 -135 -453 378ATOM 1947 O GLY 282 16.480-0.062 44.380 1.000 16.38ANISOU 1947 O GLY 282 1998 1921 2306 -211 -399 360ATOM 1948 N PHE 283 16.6250.919 42.404 1.000 13.44ANISOU 1948 N PHE 283 1563 1539 2006 -189 -336 -115ATOM 1949 CA PHE 283 15.1730.829 42.203 1.000 14.52ANISOU 1949 CA PHE 283 1677 1410 2428 -187 -670 46ATOM 1950 C PHE 283 14.810-0.604 41.809 1.000 13.08ANISOU 1950 C PHE 283 1519 1314 2137 -121 -338 174ATOM 1951 O PHE 283 15.311-1.184 40.837 1.000 14.11ANISOU 1951 O PHE 283 1566 1418 2578 -142 -7817ATOM 1952 CB PHE 283 14.7491.800 41.078 1.000 13.76ANISOU 1952 CB PHE 283 1814 1288 2125 -39-2680ATOM 1953 CGPHE 283 14.8423.269 41.512 1.000 14.75ANISOU 1953 CGPHE 283 1985 1363 225512 -317 -3ATOM 1954 CD1 PHE 283 13.8143.904 42.142 1.000 21.50ANISOU 1954 CD1 PHE 283 2318 1759 4091303 -23 -626ATOM 1955 CD2 PHE 283 15.9943.999 41.298 1.000 17.72ANISOU 1955 CD2 PHE 283 2526 1244 2963-307-89 272ATOM 1956 CE1 PHE 283 13.9095.177 42.655 1.000 20.78ANISOU 1956 CE1 PHE 283 2056 1802 403692 66 -647ATOM 1957 CE2 PHE 283 16.1155.290 41.814 1.000 15.06ANISOU 1957 CE2 PHE 283 2101 1257 2364-5 -255 377ATOM 1958 CZPHE 283 15.0845.891 42.506 1.000 18.04ANISOU 1958 CZPHE 283 1881 1995 2979192 -432 20ATOM 1959 N ASP 284 13.883-1.178 42.579 1.000 13.07ANISOU 1959 N ASP 284 1549 1366 2049-73 -331 117ATOM 1960 CAASP 284 13.502-2.584 42.395 1.000 12.80ANISOU 1960 CAASP 284 1481 1460 1924-231-207 157ATOM 1961 C ASP 284 12.335-2.654 41.421 1.000 12.88ANISOU 1961 C ASP 284 1493 1508 1891-19 -180 -55ATOM 1962 O ASP 284 11.231-3.147 41.741 1.000 13.69ANISOU 1962 O ASP 284 1407 1351 2442-93 -281 92ATOM 1963 CBASP 284 13.141-3.203 43.744 1.000 14.10ANISOU 1963 CBASP 284 1966 1534 1858-40 -11 145ATOM 1964 CGASP 284 13.165-4.730 43.717 1.000 14.49ANISOU 1964 CGASP 284 1906 1520 207947 -424 290ATOM 1965 OD1 ASP 284 13.732-5.305 42.758 1.000 14.81ANISOU 1965 OD1 ASP 284 2036 1343 2250-152-166 231ATOM 1966 OD2 ASP 284 12.652-5.310 44.696 1.000 15.32ANISOU 1966 OD2 ASP 284 1979 1557 2286-79 -109 153ATOM 1967 N VAL 285 12.644-2.191 40.217 1.000 12.40ANISOU 1967 N VAL 285 1582 1260 187079 -185 -131ATOM 1968 CAVAL 285 11.599-2.064 39.216 1.000 12.31ANISOU 1968 CAVAL 285 1442 1469 1767-161-59 -1ATOM 1969 C VAL 285 11.229-3.419 38.589 1.000 12.09ANISOU 1969 C VAL 285 1220 1407 1967-1 -100 -79ATOM 1970 O VAL 285 12.085-4.311 38.433 1.000 13.68ANISOU 1970 O VAL 285 1237 1514 244667 5640ATOM 1971 CBVAL 285 12.009-1.066 38.098 1.000 14.68ANISOU 1971 CBVAL 285 1943 1621 2014-163-50 259ATOM 1972 CG1 VAL 285 12.1310.332 38.672 1.000 17.08ANISOU 1972 CG1 VAL 285 2429 1402 265818 -465 425ATOM 1973 CG2 VAL 285 13.309-1.499 37.433 1.000 15.69ANISOU 1973 CG2 VAL 285 2131 2180 1649-316161 306ATOM 1974 N SER 286 9.952 -3.541 38.241 1.000 12.24ANISOU 1974 N SER 286 1263 1440 1946-12 -148 -117ATOM 1975 CASER 286 9.398 -4.669 37.495 1.000 12.84ANISOU 1975 CASER 286 1571 1463 1845-356-30 14ATOM 1976 C SER 286 8.861 -4.118 36.172 1.000 11.99ANISOU 1976 C SER 286 1516 1374 1666-28 60-198ATOM 1977 O SER 286 7.654 -4.110 35.917 1.000 15.68ANISOU 1977 O SER 286 1514 2384 20592 18-20ATOM 1978 CBSER 286 8.301 -5.327 38.300 1.000 12.54ANISOU 1978 CBSER 286 1407 1442 1915-59 170 -55ATOM 1979 OGSER 286 7.415 -4.380 38.890 1.000 13.15ANISOU 1979 OGSER 286 1531 1430 2034105 -73 -59ATOM 1980 N LEU 287 9.769 -3.649 35.333 1.000 13.56ANISOU 1980 N LEU 287 1574 1521 205841 133 177ATOM 1981 CALEU 287 9.451 -2.932 34.101 1.000 13.48ANISOU 1981 CALEU 287 1812 1418 1891-84 116 17ATOM 1982 C LEU 287 10.075-3.654 32.908 1.000 15.12ANISOU 1982 C LEU 287 1945 1714 208632 233 -31ATOM 1983 O LEU 287 11.277-3.883 32.927 1.000 17.91ANISOU 1983 O LEU 287 1885 2275 2645 109 300 -275ATOM 1984 CB LEU 287 9.954 -1.480 34.118 1.000 14.37ANISOU 1984 CB LEU 287 1773 1380 2306 -34 248 107ATOM 1985 CG LEU 287 9.362 -0.603 35.231 1.000 14.32ANISOU 1985 CG LEU 287 1421 1496 2523 62 52 -158ATOM 1986 CD1 LEU 287 10.143 0.705 35.413 1.000 14.53ANISOU 1986 CD1 LEU 287 1672 1444 2403 0 -146 143ATOM 1987 CD2 LEU 287 7.921 -0.197 34.820 1.000 16.03ANISOU 1987 CD2 LEU 287 1476 2035 2579 166 -100 -7ATOM 1988 N ASP 288 9.256 -4.060 31.958 1.000 15.09ANISOU 1988 N ASP 288 2041 1611 2081 73 175 -216ATOM 1989 CA ASP 288 9.764 -4.722 30.757 1.000 16.55ANISOU 1989 CA ASP 288 1992 2028 2268 29 335 -314ATOM 1990 C ASP 288 10.437 -3.682 29.874 1.000 18.74ANISOU 1990 C ASP 288 2484 2597 2040 -23197 81ATOM 1991 O ASP 288 9.998 -2.526 29.849 1.000 25.48ANISOU 1991 O ASP 288 3382 2433 3865 -322639 346ATOM 1992 CB ASP 288 8.659 -5.490 30.060 1.000 19.23ANISOU 1992 CB ASP 288 2431 2414 2460 -209258 -720ATOM 1993 CG ASP 288 9.139 -6.468 29.000 1.000 19.50ANISOU 1993 CG ASP 288 2688 2223 2499 -49 393 -552ATOM 1994 OD1 ASP 288 10.173 -7.145 29.185 1.000 27.03ANISOU 1994 OD1 ASP 288 3134 3038 4100 624 427 -716ATOM 1995 OD2 ASP 288 8.458 -6.566 27.955 1.000 31.00ANISOU 1995 OD2 ASP 288 3596 4859 3325 307 -361 -2100ATOM 1996 N GLY 289 11.489 -4.035 29.137 1.000 22.68ANISOU 1996 N GLY 289 2960 2893 2765 -531778 116ATOM 1997 CA GLY 289 12.008 -3.083 28.169 1.000 25.60ANISOU 1997 CA GLY 289 3678 3562 2486 -1469 558 11ATOM 1998 C GLY 289 12.988 -2.078 28.725 1.000 21.08ANISOU 1998 C GLY 289 2567 2916 2528 -485353 150ATOM 1999 O GLY 289 13.411 -2.097 29.891 1.000 23.72ANISOU 1999 O GLY 289 3428 3219 2364 -1104 440 113ATOM 2000 N GLU 290 13.402 -1.168 27.818 1.000 18.32ANISOU 2000 N GLU 290 2246 2396 2319 -145616 -115ATOM 2001 CA GLU 290 14.538 -0.301 28.074 1.000 17.75ANISOU 2001 CA GLU 290 1912 2419 2412 97 770 -367ATOM 2002 C GLU 290 14.261 1.058 28.696 1.000 17.90ANISOU 2002 C GLU 290 2180 2308 2313 50 711 -297ATOM 2003 O GLU 290 15.143 1.619 29.353 1.000 17.58ANISOU 2003 O GLU 290 2525 2050 2104 -35 380 165ATOM 2004 CB GLU 290 15.341 -0.161 26.785 1.000 23.21ANISOU 2004 CB GLU 290 3184 2508 3126 -2731753 -467ATOM 2005 CG GLU 290 15.833 -1.492 26.226 1.000 24.55ANISOU 2005 CG GLU 290 3609 2992 2725 348 1232 -743ATOM 2006 CD GLU 290 16.676 -2.280 27.221 1.000 30.03ANISOU 2006 CD GLU 290 3365 3708 4337 476 753 -211ATOM 2007 OE1 GLU 290 17.492 -1.684 27.947 1.000 40.04ANISOU 2007 OB1 GLU 290 5043 6674 3498 525 36 -1226ATOM 2008 OE2 GLU 290 16.622 -3.527 27.237 1.000 51.76ANISOU 2008 OE2 GLU 290 8785 3812 7070 -12 -483 1583ATOM 2009 N THR 291 13.064 1.578 28.486 1.000 18.14ANISOU 2009 N THR 291 2305 2486 2103 224 711 -321ATOM 2010 CA THR 291 12.697 2.896 29.049 1.000 18.72ANISOU 2010 CA THR 291 2521 2080 2511 105 1131 66ATOM 2011 C THR 291 11.278 2.744 29.593 1.000 15.79ANISOU 2011 C THR 291 2178 1758 2064 134 538 -50ATOM 2012 O THR 291 10.517 1.834 29.217 1.000 18.62ANISOU 2012 O THR 291 2764 1966 2344 -248664 -311ATOM 2013 CB THR 291 12.722 4.031 28.044 1.000 21.54ANISOU 2013 CB THR 291 3043 2625 2516 -164891 362ATOM 2014 OG1 THR 291 11.695 3.86227.077 1.000 25.98ANISOU 2014 OG1 THR 291 31604072 2641 -86703 503ATOM 2015 CG2 THR 291 14.048 4.11527.292 1.000 24.20ANISOU 2015 CG2 THR 291 31993832 2164 -445 930 533ATOM 2016 NALA 292 10.959 3.65830.492 1.000 14.84ANISOU 2016 NALA 292 16371656 2347 200429 -153ATOM 2017 CA ALA 292 9.675 3.65731.179 1.000 13.84ANISOU 2017 CA ALA 292 14881477 2294 170299 78ATOM 2018 CALA 292 9.356 5.06531.619 1.000 12.65ANISOU 2018 CALA 292 13341564 1908 60 144 -139ATOM 2019 OALA 292 10.228 5.93931.710 1.000 14.27ANISOU 2019 OALA 292 15291596 2295 -35109 116ATOM 2020 CB ALA 292 9.670 2.75432.414 1.000 14.02ANISOU 2020 CB ALA 292 16931580 2053 37 22 -27ATOM 2021 NTHR 293 8.054 5.25831.916 1.000 13.54ANISOU 2021 NTHR 293 14681617 2058 117373 -118ATOM 2022 CA THR 293 7.605 6.54632.424 1.000 13.40ANISOU 2022 CA THR 293 15651647 1877 152209 -232ATOM 2023 CTHR 293 7.407 6.48233.952 1.000 12.09ANISOU 2023 CTHR 293 13451322 1927 -62326 -12ATOM 2024 OTHR 293 7.214 5.44134.555 1.000 12.93ANISOU 2024 OTHR 293 13851356 2170 -190 194 90ATOM 2025 CB THR 293 6.295 7.05831.788 1.000 13.45ANISOU 2025 CB THR 293 15981579 1935 95 345 345ATOM 2026 OG1 THR 293 5.273 6.11232.117 1.000 13.75ANISOU 2026 OG1 THR 293 16721570 1981 -12314 135ATOM 2027 CG2 THR 293 6.476 7.13930.272 1.000 15.93ANISOU 2027 CG2 THR 293 21212022 1911 255434 337ATOM 2028 NPHE 294 7.241 7.66134.544 1.000 12.81ANISOU 2028 NPHE 294 16071440 1822 -83149 -151ATOM 2029 CA PHE 294 6.857 7.77335.935 1.000 12.37ANISOU 2029 CA PHE 294 13321469 1899 -267 166 -289ATOM 2030 CPHE 294 5.556 7.02236.184 1.000 12.36ANISOU 2030 CPHE 294 13361361 1999 -151 30 -36ATOM 2031 OPHE 294 5.403 6.25337.143 1.000 13.27ANISOU 2031 OPHE 294 15561410 2076 -191 183 46ATOM 2032 CB PHE 294 6.698 9.27136.267 1.000 13.83ANISOU 2032 CB PHE 294 20391351 1866 -192 -29 -177ATOM 2033 CG PHE 294 6.306 9.48837.711 1.000 13.10ANISOU 2033 CG PHE 294 17861216 1974 -125 -63 -244ATOM 2034 CD1 PHE 294 7.207 9.41138.749 1.000 17.41ANISOU 2034 CD1 PHE 294 21322533 1952 -1012 -287 76ATOM 2035 CD2 PHE 294 4.964 9.73938.026 1.000 18.41ANISOU 2035 CD2 PHE 294 21562263 2575 565332 57ATOM 2036 CE1 PHE 294 6.810 9.60840.054 1.000 17.72ANISOU 2036 CE1 PHE 294 23482296 2086 -308 -362 -136ATOM 2037 CE2 PHE 294 4.591 10.010 39.324 1.000 19.37ANISOU 2037 CE2 PHE 294 20782541 2740 330232 -630ATOM 2038 CZ PHE 294 5.507 9.95640.355 1.000 18.36ANISOU 2038 CZ PHE 294 24431678 2855 -394 -55 -245ATOM 2039 NGLN 295 4.588 7.20535.246 1.000 12.59ANISOU 2039 NGLN 295 12481429 2106 -6238 -168ATOM 2040 CA GLN 295 3.320 6.48435.408 1.000 12.76ANISOU 2040 CA GLN 295 12661215 2365 7 -157 -117ATOM 2041 CGLN 295 3.512 4.98435.318 1.000 12.24ANISOU 2041 CGLN 295 14491256 1944 10 1-73ATOM 2042 OGLN 295 2.922 4.23836.101 1.000 13.61ANISOU 2042 OGLN 295 13231427 2424 7 85 155ATOM 2043 CB GLN 295 2.375 6.97534.317 1.000 14.31ANISOU 2043 CB GLN 295 12271594 2616 81 -133 192ATOM 2044 CG GLN 295 1.062 6.25634.249 1.000 14.03ANISOU 2044 CG GLN 295 1391 15092430 -59 -300 47ATOM2045 CD GLN 295 0.157 6.687 33.115 1.000 13.56ANISOU 2045 CD GLN 295 1305 14862361 133 -117 165ATOM2046 OE1 GLN 295 0.459 7.693 32.419 1.000 15.35ANISOU 2046 OE1 GLN 295 1811 16512371 161 206 220ATOM2047 NE2 GLN 295 -0.982 6.026 32.943 1.000 15.04ANISOU 2047 NE2 GLN 295 1225 19952493 75 -13 -99ATOM2048 N ASP 296 4.363 4.463 34.423 1.000 12.66ANISOU 2048 N ASP 296 1425 13961990 181 -112 -110ATOM2049 CA ASP 296 4.653 3.016 34.439 1.000 12.26ANISOU 2049 CA ASP 296 1628 12741755 53 -51 -151ATOM2050 C ASP 296 5.167 2.569 35.792 1.000 11.57ANISOU 2050 C ASP 296 1199 13001895 -82 30-22ATOM2051 O ASP 296 4.854 1.460 36.224 1.000 13.08ANISOU 2051 O ASP 296 1534 13682070 -10738139ATOM2052 CB ASP 296 5.709 2.634 33.399 1.000 14.18ANISOU 2052 CB ASP 296 1870 17001819 141 30-378ATOM2053 CG ASP 296 5.295 2.848 31.952 1.000 13.32ANISOU 2053 CG ASP 296 1655 15571848 -58 672ATOM2054 OD1 ASP 296 4.110 2.725 31.601 1.000 15.83ANISOU 2054 OD1 ASP 296 1680 19352402 -68 -126 -189ATOM2055 OD2 ASP 296 6.212 3.098 31.114 1.000 15.27ANISOU 2055 OD2 ASP 296 1757 19372106 -229137 177ATOM2056 N TRP 297 6.038 3.352 36.416 1.000 12.26ANISOU 2056 N TRP 297 1325 14031931 -34 -123 -118ATOM2057 CA TRP 297 6.683 2.960 37.656 1.000 12.82ANISOU 2057 CA TRP 297 1328 15991943 -104-49 151ATOM2058 C TRP 297 5.746 3.007 38.858 1.000 13.13ANISOU 2058 C TRP 297 1418 15801992 24 -23 185ATOM2059 O TRP 297 5.565 2.030 39.584 1.000 14.03ANISOU 2059 O TRP 297 1554 16192159 102 137 320ATOM2060 CB TRP 297 7.908 3.847 37.928 1.000 13.68ANISOU 2060 CB TRP 297 1130 16922376 -19 -169 151ATOM2061 CG TRP 297 8.646 3.455 39.166 1.000 13.28ANISOU 2061 CG TRP 297 1143 16462255 91 -96 22ATOM2062 CD1 TRP 297 8.932 2.179 39.622 1.000 15.58ANISOU 2062 CD1 TRP 297 1615 16892618 275 -544 -77ATOM2063 CD2 TRP 297 9.144 4.353 40.189 1.000 14.69ANISOU 2063 CD2 TRP 297 1327 16932562 -117-219 5ATOM2064 NE1 TRP 297 9.583 2.265 40.840 1.000 15.34ANISOU 2064 NE1 TRP 297 1378 18532598 70 -494 75ATOM2065 CE2 TRP 297 9.724 3.597 41.203 1.000 16.13ANISOU 2065 CE2 TRP 297 1241 20092880 182 -676 -196ATOM2066 CE3 TRP 297 9.094 5.756 40.284 1.000 22.13ANISOU 2066 CE3 TRP 297 3040 16583712 -665-1408 129ATOM2067 CZ2 TRP 297 10.318 4.180 42.316 1.000 18.45ANISOU 2067 CZ2 TRP 297 2204 23872418 44 -326 -331ATOM2068 CZ3 TRP 297 9.670 6.353 41.399 1.000 21.55ANISOU 2068 CZ3 TRP 297 2916 21043167 -55 -752 -458ATOM2069 CH2 TRP 297 10.258 5.546 42.397 1.000 23.53ANISOU 2069 CH2 TRP 297 3298 23563285 -320-1146 -344ATOM2070 N ILE 298 5.106 4.167 39.044 1.000 13.58ANISOU 2070 N ILE 298 1324 17262108 241 -167 127ATOM2071 CA ILE 298 4.299 4.440 40.229 1.000 14.68ANISOU 2071 CA ILE 298 1413 21771986 -13 -161 -208ATOM2072 C ILE 298 2.841 4.054 40.121 1.000 12.02ANISOU 2072 C ILE 298 1455 13001813 56 -239 402ATOM2073 O ILE 298 2.182 3.782 41.147 1.000 13.67ANISOU 2073 O ILE 298 1732 15821881 -23 -4193ATOM2074 CB ILE 298 4.428 5.914 40.673 1.000 19.45ANISOU 2074 CB ILE 298 2261 24462683 -699237 -835ATOM 2075 CG1 ILE 298 5.907 6.245 41.001 1.000 27.83ANISOU 2075 CG1 ILE 298 2776 4275 3525 -1314 -556 -1030ATOM 2076 CG2 ILE 298 3.679 6.319 41.929 1.000 25.05ANISOU 2076 CG2 ILE 298 3770 3344 2405 -57255 -983ATOM 2077 CD1 ILE 298 6.368 5.628 42.306 1.000 43.32ANISOU 2077 CD1 ILE 298 4561 7224 4674 -652 -1890 -117ATOM 2078 NGLY 299 2.317 3.980 38.893 1.000 12.16ANISOU 2078 NGLY 299 1432 1308 1879 78 -304 106ATOM 2079 CA GLY 299 0.918 3.741 38.670 1.000 12.98ANISOU 2079 CA GLY 299 1276 1279 2379 106-188 -154ATOM 2080 CGLY 299 0.135 5.017 38.378 1.000 13.09ANISOU 2080 CGLY 299 1421 1403 2151 113-231 118ATOM 2081 OGLY 299 0.738 6.025 38.017 1.000 14.00ANISOU 2081 OGLY 299 1713 1353 2252 122289 -13ATOM 2082 NGLY 300 -1.183 4.917 38.447 1.000 13.08ANISOU 2082 NGLY 300 1325 1545 2099 146-267 -145ATOM 2083 CA GLY 300 -2.075 5.966 37.992 1.000 13.45ANISOU 2083 CA GLY 300 1447 1521 2143 116-415 -143ATOM 2084 CGLY 300 -2.519 6.972 39.042 1.000 12.94ANISOU 2084 CGLY 300 1098 1365 2456 -52-407 -192ATOM 2085 OGLY 300 -3.262 7.875 38.672 1.000 13.39ANISOU 2085 OGLY 300 1321 1342 2423 -19-217 -45ATOM 2086 NASN 301 -1.973 6.845 40.254 1.000 13.35ANISOU 2086 NASN 301 1494 1429 2151 -225 -232 -104ATOM 2087 CA ASN 301 -2.162 7.842 41.313 1.000 13.83ANISOU 2087 CA ASN 301 1590 1435 2230 -194 -38 -61ATOM 2088 CASN 301 -0.837 8.254 41.885 1.000 12.46ANISOU 2088 CASN 301 1676 1268 1791 -35-142 -20ATOM 2089 OASN 301 -0.007 7.405 42.169 1.000 13.89ANISOU 2089 OASN 301 1831 1355 2093 73 -144 -13ATOM 2090 CB ASN 301 -3.075 7.238 42.360 1.000 16.01ANISOU 2090 CB ASN 301 1632 1909 2542 77 224 315ATOM 2091 CG ASN 301 -3.942 8.199 43.106 1.000 18.23ANISOU 2091 CG ASN 301 1986 2508 2435 190152 -90ATOM 2092 OD1 ASN 301 -4.973 8.690 42.614 1.000 17.44ANISOU 2092 OD1 ASN 301 1606 1626 3394 -21144 -190ATOM 2093 ND2 ASN 301 -3.518 8.454 44.338 1.000 33.30ANISOU 2093 ND2 ASN 301 2804 6923 2928 1012 -230 -1523ATOM 2094 NTYR 302 -0.595 9.564 42.073 1.000 12.96ANISOU 2094 NTYR 302 1662 1278 1985 -69-21 -135ATOM 2095 CA TYR 302 0.674 9.948 42.702 1.000 13.48ANISOU 2095 CA TYR 302 1673 1259 2192 -130 -132 34ATOM 2096 CTYR 302 0.768 9.269 44.078 1.000 12.63ANISOU 2096 CTYR 302 1413 1293 2092 53 44 19ATOM 2097 OTYR 302 -0.218 9.151 44.806 1.000 14.15ANISOU 2097 OTYR 302 1332 1737 2305 -6548 -27ATOM 2098 CB TYR 302 0.764 11.472 42.916 1.000 13.30ANISOU 2098 CB TYR 302 1635 1192 2226 -8133 41ATOM 2099 CG TYR 302 1.159 12.143 41.619 1.000 12.02ANISOU 2099 CG TYR 302 1586 1103 1880 -59-25 -271ATOM 2100 CD1 TYR 302 2.501 12.233 41.275 1.000 13.11ANISOU 2100 CD1 TYR 302 1633 1284 2066 -8011 -18ATOM 2101 CD2 TYR 302 0.235 12.709 40.739 1.000 12.52ANISOU 2101 CD2 TYR 302 1576 1132 2049 -4413 -127ATOM 2102 CE1 TYR 302 2.933 12.822 40.119 1.000 12.29ANISOU 2102 CE1 TYR 302 1581 1043 2045 -185 -84 -77ATOM 2103 CE2 TYR 302 0.637 13.273 39.535 1.000 14.12ANISOU 2103 CE2 TYR 302 1462 1443 2458 -241 15 325ATOM 2104 CZ TYR 302 1.983 13.347 39.241 1.000 12.69ANISOU 2104 CZ TYR 302 1483 1224 2113 -287 -91 10ATOM 2105 OH TYR 302 2.376 13.866 38.013 1.000 13.42ANISOU 2105 OH TYR 302 15051469 2124 -93 33 146ATOM 2106 N VAL 303 1.956 8.855 44.450 1.000 13.92ANISOU 2106 N VAL 303 14061637 2246 153 88 99ATOM 2107 CA VAL 303 2.355 8.336 45.746 1.000 14.51ANISOU 2107 CA VAL 303 18381320 2355 -137 -391 -74ATOM 2108 C VAL 303 3.498 9.244 46.239 1.000 15.23ANISOU 2108 C VAL 303 14041507 2876 -102 -105 -348ATOM 2109 O VAL 303 4.471 9.386 45.512 1.000 18.70ANISOU 2109 O VAL 303 18591861 3386 -239 326 -504ATOM 2110 CB VAL 303 2.856 6.880 45.632 1.000 16.75ANISOU 2110 CB VAL 303 21401319 2905 16-759 -123ATOM 2111 CG1 VAL 303 3.279 6.401 47.017 1.000 19.53ANISOU 2111 CG1 VAL 303 21851951 3284 232 -1054 148ATOM 2112 CG2 VAL 303 1.723 5.956 45.125 1.000 17.82ANISOU 2112 CG2 VAL 303 24761442 2852 -213 -558 -406ATOM 2113 N ASN 304 3.349 9.900 47.378 1.000 14.07ANISOU 2113 N ASN 304 14091369 2566 -39 -407 -86ATOM 2114 CA ASN 304 4.317 10.928 47.772 1.000 14.31ANISOU 2114 CA ASN 304 14741387 2578 -102 -424 -55ATOM 2115 C ASN 304 5.450 10.397 48.637 1.000 13.75ANISOU 2115 C ASN 304 13601487 2378 34-274 -87ATOM 2116 O ASN 304 6.539 10.962 48.584 1.000 14.60ANISOU 2116 O ASN 304 13141795 2438 -34 -55 -320ATOM 2117 CB ASN 304 3.589 12.035 48.551 1.000 14.26ANISOU 2117 CB ASN 304 17101214 2494 6 -303 176ATOM 2118 CG ASN 304 2.535 12.661 47.642 1.000 14.81ANISOU 2118 CG ASN 304 15511627 2449 23-114 402ATOM 2119 OD1 ASN 304 2.866 13.255 46.622 1.000 16.52ANISOU 2119 OD1 ASN 304 18961746 2636 8019 589ATOM 2120 ND2 ASN 304 1.290 12.595 48.102 1.000 18.43ANISOU 2120 ND2 ASN 304 15602980 2463 127 -10 199ATOM 2121 N ILE 305 5.175 9.413 49.463 1.000 16.36ANISOU 2121 N ILE 305 15461553 3117 -78 -503 266ATOM 2122 CA ILE 305 6.173 8.890 50.407 1.000 14.85ANISOU 2122 CA ILE 305 16701537 2436 165 -277 -40ATOM 2123 C ILE 305 6.183 7.372 50.352 1.000 15.78ANISOU 2123 C ILE 305 15271555 2914 95-438 -51ATOM 2124 O ILE 305 5.231 6.736 49.886 1.000 17.54ANISOU 2124 O ILE 305 14631789 3412 -131 -404 5ATOM 2125 CB ILE 305 5.949 9.430 51.818 1.000 17.80ANISOU 2125 CB ILE 305 21671962 2634 -23 265 -209ATOM 2126 CG1 ILE 305 4.578 9.091 52.416 1.000 18.93ANISOU 2126 CG1 ILE 305 17162948 2526 1 -218 -163ATOM 2127 CG2 ILE 305 6.171 10.944 51.823 1.000 19.17ANISOU 2127 CG2 ILE 305 26851863 2737 70-534 -405ATOM 2128 CD1 ILE 305 4.415 9.459 53.863 1.000 21.28ANISOU 2128 CD1 ILE 305 25212902 2662 19452 -71ATOM 2129 N ARG 306 7.246 6.806 50.908 1.000 14.59ANISOU 2129 N ARG 306 17381641 2165 52-356 271ATOM 2130 CA ARG 306 7.424 5.360 50.828 1.000 15.25ANISOU 2130 CA ARG 306 15091663 2622 139 -302 77ATOM 2131 C ARG 306 8.234 4.903 52.024 1.000 15.02ANISOU 2131 C ARG 306 15881464 2656 133 -332 -21ATOM 2132 O ARG 306 9.141 5.614 52.433 1.000 16.63ANISOU 2132 O ARG 306 16822101 2536 -219 -294 -168ATOM 2133 CB ARG 306 8.135 4.943 49.532 1.000 16.31ANISOU 2133 CB ARG 306 18201681 2697 -100 -270 -150ATOM 2134 CG ARG 306 8.226 3.414 49.377 1.000 18.43ANISOU 2134 CG ARG 306 24761700 2828 40-194 -156ATOM 2135 CD ARG 306 8.401 3.068 47.900 1.000 18.26ANISOU 2135 CD ARG 306 20871971 2880 -120 -145 -330ATOM2136 NE ARG 306 7.136 3.228 47.188 1.000 20.53ANISOU 2136 NE ARG 306 2442 20133345 -577 -668 -234ATOM2137 CZ ARG 306 6.980 3.178 45.873 1.000 20.27ANISOU 2137 CZ ARG 306 2330 20573316 373-522 20ATOM2138 NH1 ARG 306 8.086 3.000 45.107 1.000 22.13ANISOU 2138 NH1 ARG 306 2136 25803695 274-589 -723ATOM2139 NH2 ARG 306 5.759 3.250 45.341 1.000 18.44ANISOU 2139 NH2 ARG 306 2107 18383062 259-286 84ATOM2140 NARG 307 7.898 3.775 52.612 1.000 19.10ANISOU 2140 NARG 307 2716 18722671 -294 -607 327ATOM2141 CA ARG 307 8.576 3.212 53.768 1.000 21.13ANISOU 2141 CA ARG 307 3321 22012504 -48-845 139ATOM2142 CARG 307 9.536 2.138 53.277 1.000 23.30ANISOU 2142 CARG 307 3417 21703267 181-1046 39ATOM2143 OARG 307 9.385 1.601 52.187 1.000 21.01ANISOU 2143 OARG 307 2574 23553052 174-728 112ATOM2144 CB ARG 307 7.557 2.522 54.694 1.000 27.30ANISOU 2144 CB ARG 307 4545 31842645 -13-247 705ATOM2145 CG ARG 307 6.839 3.488 55.629 1.000 46.30ANISOU 2145 CG ARG 307 6310 63744907 2151655 -970ATOM2146 CD ARG 307 7.054 3.085 57.085 1.000 66.50ANISOU 2146 CD ARG 307 1110710355 3806 -2980 2792 -1145ATOM2147 NE ARG 307 5.989 2.203 57.531 1.000 78.91ANISOU 2147 NE ARG 307 1182112833 5330 -4530 1969 -5ATOM2148 CZ ARG 307 5.987 1.285 58.479 1.000 73.67ANISOU 2148 CZ ARG 307 7704 14382 5907 -4724 1249 1051ATOM2149 NH1 ARG 307 7.063 1.038 59.214 1.000 80.32ANISOU 2149 NH1 ARG 307 6613 17949 5955 -3290 2179 105ATOM2150 NH2 ARG 307 4.872 0.597 58.707 1.000 73.74ANISOU 2150 NH2 ARG 307 9116 15919 2983 -6954 438 -917ATOM2151 NTHR 308 10.551 1.861 54.113 1.000 25.61ANISOU 2151 NTHR 308 4234 22123285 536-1421 -232ATOM2152 CA THR 308 11.308 0.640 53.822 1.000 30.02ANISOU 2152 CA THR 308 3468 19395998 225-1629 -194ATOM2153 CTHR 308 10.468 -0.611 54.030 1.000 25.42ANISOU 2153 CTHR 308 2915 21904552 453-626 -321ATOM2154 OTHR 308 9.523 -0.768 54.787 1.000 30.10ANISOU 2154 OTHR 308 4042 34823912 614-217 -125ATOM2155 CB THR 308 12.581 0.531 54.688 1.000 26.09ANISOU 2155 CB THR 308 2701 35863626 242-361 -456ATOM2156 OG1 THR 308 12.140 0.751 56.028 1.000 32.90ANISOU 2156 OG1 THR 308 4146 41884167 504745 -495ATOM2157 CG2 THR 308 13.577 1.594 54.256 1.000 31.43ANISOU 2157 CG2 THR 308 3193 47024047 -577 -132 -538ATOM2158 NSER 309 10.850 -1.591 53.217 1.000 24.73ANISOU 2158 NSER 309 2934 20924370 94 -574 -391ATOM2159 CA SER 309 10.199 -2.897 53.230 1.000 25.19ANISOU 2159 CA SER 309 3793 24643316 -485 451 -230ATOM2160 CSER 309 10.466 -3.691 54.512 1.000 24.06ANISOU 2160 CSER 309 2360 28883893 302107 35ATOM2161 OSER 309 11.565 -3.621 55.084 1.000 34.54ANISOU 2161 OSER 309 3626 2131 7366 -76-1944 -34ATOM2162 CB SER 309 10.639 -3.700 52.012 1.000 26.52ANISOU 2162 CB SER 309 3970 2159 3948 167580 -366ATOM2163 OG SER 309 10.217 -5.039 52.148 1.000 26.34ANISOU 2163 OG SER 309 3198 2207 4604 156-844 -260ATOM2164 NLYS 310 9.494-4.458 54.961 1.000 24.99ANISOU 2164 NLYS 310 3172 2459 3864 160262 366ATOM2165 CA LYS 310 9.651-5.339 56.125 1.000 28.38ANISOU 2165 CA LYS 310 41913167 3427 764278 281ATOM2166 CLYS 310 9.941-6.768 55.711 1.000 26.07ANISOU 2166 C LYS 310 3371 26873846 168 -290 577ATOM 2167 O LYS 310 10.150 -7.684 56.515 1.000 33.48ANISOU 2167 O LYS 310 5267 30564400 -66 -450 1073ATOM 2168 CB LYS 310 8.299 -5.367 56.858 1.000 37.77ANISOU 2168 CB LYS 310 5736 46953921 299 1818 18ATOM 2169 CG LYS 310 8.014 -4.214 57.806 1.000 40.55ANISOU 2169 CG LYS 310 6395 47164295 1525 1524 101ATOM 2170 CD LYS 310 6.798 -4.587 58.649 1.000 44.24ANISOU 2170 CD LYS 310 9091 42243495 1053 2816 584ATOM 2171 CE LYS 310 6.722 -6.109 58.818 1.000 59.12ANISOU 2171 CE LYS 310 9281 45778606 766 -82 2478ATOM 2172 NZ LYS 310 6.088 -6.563 60.089 1.000 55.80ANISOU 2172 NZ LYS 310 4884 574210577 287 -947 4796ATOM 2173 N ALA 311 9.896 -7.030 54.410 1.000 22.45ANISOU 2173 N ALA 311 2190 24023939 1052 269ATOM 2174 CA ALA 311 10.360 -8.369 53.972 1.000 31.89ANISOU 2174 CA ALA 311 3771 25945753 434 -516 -421ATOM 2175 C ALA 311 11.909 -8.459 53.833 1.000 23.30ANISOU 2175 C ALA 311 3907 23282616 1393 -593 112ATOM 2176 CB ALA 311 9.619 -8.665 52.674 1.000 27.94ANISOU 2176 CB ALA 311 2407 28785329 -355 542 -672ATOM 2177 OW HOH 501 -6.477 10.237 44.256 1.000 15.66ATOM 2178 OW HOH 502 -9.349 16.189 51.010 1.000 19.26ATOM 2179 OW HOH 503 -1.489 3.653 34.560 1.000 15.78ATOM 2180 OW HOH 504 -10.499 18.731 50.182 1.000 16.19ATOM 2181 OW HOH 505 -8.612 16.958 47.640 1.000 17.30ATOM 2182 OW HOH 506 -10.255 20.839 42.881 1.000 19.05ATOM 2183 OW HOH 507 2.096 1.076 32.810 1.000 29.32ATOM 2184 OW HOH 508 -0.284 4.743 41.885 1.000 13.93ATOM 2185 OW HOH 509 -8.525 18.553 42.416 1.000 21.33ATOM 2186 OW HOH 510 3.165 2.604 43.488 1.000 24.59ATOM 2187 OW HOH 511 -6.282 19.386 52.341 1.000 18.98ATOM 2188 OW HOH 512 -6.826 24.638 46.833 1.000 21.77ATOM 2189 OW HOH 513 10.510 -4.344 46.092 1.000 25.88ATOM 2190 OW HOH 514 -0.806 16.964 40.372 1.000 16.54ATOM 2191 OW HOH 515 -1.269 18.855 42.411 1.000 15.76ATOM 2192 OW HOH 516 14.277 -5.146 40.175 1.000 15.53ATOM 2193 OW HOH 517 -0.123 21.538 40.640 1.000 17.22ATOM 2194 OW HOH 518 13.131 -0.967 51.791 1.000 31.17ATOM 2195 OW HOH 519 11.009 2.875 45.599 1.000 20.20ATOM 2196 OW HOH 520 5.789 13.543 45.996 1.000 17.36ATOM 2197 OW HOH 521 2.168 19.767 55.925 1.000 20.41ATOM 2198 OW HOH 522 8.487 15.960 34.949 1.000 15.40ATOM 2199 OW HOH 523 10.794 12.697 29.921 1.000 19.99ATOM 2200 OW HOH 524 -11.722 19.112 44.516 1.000 19.82ATOM 2201 OW HOH 525 1.672 -2.081 35.124 1.000 16.29ATOM 2202 OW HOH 526 9.651 15.283 32.342 1.000 20.37ATOM 2203 OW HOH 527 28.749 31.187 52.019 1.000 18.53ATOM 2204 OW HOH 528 15.326 11.252 32.041 1.000 19.60ATOM 2205 OW HOH 529 26.897 26.984 52.035 1.000 19.86ATOM 2206 OW HOH 530 13.528 11.592 50.915 1.000 16.17ATOM 2207 OW HOH 531 25.631 32.409 52.682 1.000 19.20ATOM 2208 OW HOH 532 18.287 6.835 52.185 1.000 18.49ATOM 2209 OW HOH 533 12.635 29.035 39.395 1.000 18.09ATOM 2210 OW HOH 534 10.797 31.968 45.659 1.000 20.66ATOM 2211 OW HOH 535 10.167 24.890 33.567 1.000 19.12ATOM 2212 OW HOH 536 23.530 24.122 58.531 1.000 20.39ATOM 2213 OW HOH 537 23.358 12.639 35.292 1.000 22.61ATOM 2214 OW HOH 538 25.879 28.699 50.264 1.000 19.44ATOM 2215 OW HOH 539 11.674 16.559 30.502 1.000 18.57ATOM 2216 OW HOH 540 18.515 27.775 40.042 1.000 22.23ATOM2217 OWHOH 541 21.23320.367 33.996 1.000 21.45ATOM2218 OWHOH 542 22.82632.643 53.094 1.000 19.38ATOM2219 OWHOH 543 19.67022.387 35.310 1.000 20.05ATOM2220 OWHOH 544 -13.591 21.996 61.494 1.000 49.93ATOM2221 OWHOH 545 21.29511.783 55.080 1.000 20.04ATOM2222 OWHOH 546 5.431 2.533 51.677 1.000 28.11ATOM2223 OWHOH 547 17.31125.489 32.148 1.000 24.38ATOM2224 OWHOH 548 17.4277.744 33.008 1.000 20.78ATOM2225 OWHOH 549 11.65623.874 58.194 1.000 23.39ATOM2226 OWHOH 550 8.037 14.987 53.326 1.000 33.52ATOM2227 OWHOH 551 1.354 14.574 33.889 1.000 21.05ATOM2228 OWHOH 552 11.20320.116 63.686 1.000 24.59ATOM2229 OWHOH 553 2.671 21.240 34.245 1.000 34.51ATOM2230 OWH0H 554 6.339 19.832 30.751 1.000 26.36ATOM2231 OWHOH 555 26.61124.519 55.570 1.000 21.22ATOM2232 OWHOH 556 27.66917.156 53.039 1.000 25.86ATOM2233 OWHOH 557 -14.392 19.977 44.154 1.000 25.03ATOM2234 OWHOH 558 14.82832.652 51.443 1.000 25.23ATOM2235 OWHOH 559 17.9377.207 54.915 1.000 20.59ATOM2236 OWHOH 560 10.729-8.875 31.499 1.000 24.65ATOM2237 OWHOH 561 6.455 2.298 42.613 1.000 22.74ATOM2238 OWHOH 562 13.78431.245 44.166 1.000 27.75ATOM2239 OWHOH 563 17.29233.470 53.556 1.000 25.28ATOM2240 OWHOH 564 11.2101.109 49.697 1.000 23.33ATOM2241 OWHOH 565 -11.339 25.246 41.370 1.000 26.08ATOM2242 OWHOH 566 20.363-8.375 38.242 1.000 30.07ATOM2243 OWHOH 567 3.890 24.604 35.837 1.000 25.86ATOM2244 OWHOH 568 5.334 11.875 43.937 1.000 25.45ATOM2245 OWHOH 569 7.861 22.385 64.046 1.000 28.98ATOM2246 OWHOH 570 7.754 -1.508 30.848 1.000 24.72ATOM2247 OWHOH 571 6.297 3.583 28.471 1.000 33.06ATOM2248 OWHOH 572 -15.790 28.800 51.855 1.000 30.09ATOM2249 OWHOH 573 -5.38820.310 38.883 1.000 23.64ATOM2250 OWHOH 574 17.65721.059 29.053 1.000 24.31ATOM2251 OWHOH 575 8.763 20.920 66.102 1.000 24.81ATOM2252 OWH0H 576 10.13527.617 58.357 1.000 25.12ATOM2253 OWHOH 577 7.795 1.060 29.730 1.000 29.00ATOM2254 OWHOH 578 22.60119.580 61.946 1.000 28.66ATOM2255 OWHOH 579 8.859 4.744 27.898 1.000 26.12ATOM2256 OWHOH 580 4.937 3.932 48.882 1.000 26.29ATOM2257 OWHOH 581 17.0965.891 35.057 1.000 23.31ATOM2258 OWHOH 582 -16.337 31.047 64.719 1.000 54.01ATOM2259 OWHOH 583 7.652 24.826 52.106 1.000 27.23ATOM2260 OWHOH 584 7.174 24.915 29.292 1.000 26.60ATOM2261 OWHOH 585 23.45210.614 55.439 1.000 26.42ATOM2262 OWHOH 586 12.64026.413 58.676 1.000 27.15ATOM2263 OWHOH 587 6.204 21.166 62.094 1.000 24.65ATOM2264 OWHOH 588 2.385 0.810 37.616 1.000 19.92ATOM2265 OWHOH 589 32.93028.236 45.738 1.000 38.29ATOM2266 OWHOH 590 -12.045 28.716 45.065 1.000 30.46ATOM2267 OWHOH 591 0.219 13.612 36.120 1.000 27.12ATOM2268 OWHOH 592 -2.5253.881 43.344 1.000 26.67ATOM2269 OWHOH 593 7.533 13.297 48.055 1.000 19.59ATOM2270 OWHOH 594 -1.57528.355 42.057 1.000 25.53ATOM2271 OWHOH 595 11.209-1.188 46.425 1.000 22.12ATOM2272 OWHOH 596 5.684 -7.000 28.451 1.000 27.97ATOM2273 OWHOH 597 28.86819.406 51.825 1.000 27.72ATOM2274 OWHOH 598 13.4322.493 57.904 1.000 31.12ATOM2275 OWHOH 599 8.196 7.483 27.148 1.000 29.99ATOM2276 OWHOH 600 20.80919.088 63.369 1.000 36.86ATOM2277 OWHOH 601 21.35210.656 34.614 1.000 30.60ATOM 2278 OW HOH 602 2.891 7.196 30.899 1.000 25.41ATOM 2279 OW HOH 603 8.260 26.496 34.561 1.000 35.71ATOM 2280 OW HOH 604 22.300 13.959 31.378 1.000 32.53ATOM 2281 OW HOH 605 15.689 35.750 48.870 1.000 31.17ATOM 2282 OW HOH 606 7.219 15.638 30.914 1.000 27.80ATOM 2283 OW HOH 607 -3.237 14.604 47.092 1.000 20.96ATOM 2284 OW HOH 608 17.543 10.581 33.561 1.000 23.51ATOM 2285 OW HOH 609 -1.899 36.370 44.261 1.000 32.64ATOM 2286 OW HOH 610 26.095 14.431 43.803 1.000 19.19ATOM 2287 OW HOH 611 27.664 13.183 41.954 1.000 26.48ATOM 2288 OW HOH 612 4.302 34.604 49.981 1.000 24.70ATOM 2289 OW HOH 613 -15.580 27.012 46.728 1.000 42.45ATOM 2290 OW HOH 614 1.615 35.544 50.347 1.000 23.78ATOM 2291 OW HOH 615 -10.137 34.259 49.033 1.000 23.94ATOM 2292 OW HOH 616 26.084 6.502 57.657 1.000 39.32ATOM 2293 OW HOH 617 -15.962 20.656 46.340 1.000 25.94ATOM 2294 OW HOH 618 6.113 29.517 40.143 1.000 29.43ATOM 2295 OW HOH 619 19.797 4.627 51.313 1.000 27.15ATOM 2296 OW HOH 620 -1.748 11.315 48.716 1.000 21.83ATOM 2297 OW HOH 621 11.099 34.289 44.259 1.000 27.15ATOM 2298 OW HOH 622 28.352 14.351 37.877 1.000 41.48ATOM 2299 OW HOH 623 -2.826 36.968 57.149 1.000 32.75ATOM 2300 OW HOH 624 16.983 9.258 29.962 1.000 32.82ATOM 2301 OW HOH 625 16.780 29.213 38.384 1.000 27.96ATOM 2302 OW HOH 626 1.632 17.213 33.689 1.000 23.17ATOM 2303 OW HOH 627 33.536 23.640 45.028 1.000 41.91ATOM 2304 OW HOH 628 23.821 6.059 50.174 1.000 34.22ATOM 2305 OW HOH 629 3.482 2.785 46.751 1.000 39.07ATOM 2306 OW HOH 630 20.218 24.803 60.918 1.000 50.12ATOM 2307 OW HOH 631 3.366 16.272 30.698 1.000 31.50ATOM 2308 OW HOH 632 18.871 11.791 31.384 1.000 30.78ATOM 2309 OW HOH 633 4.455 25.782 58.823 1.000 32.14ATOM 2310 OW HOH 634 24.721 5.202 40.319 1.000 40.13ATOM 2311 OW HOH 635 19.623 35.238 43.466 1.000 50.48ATOM 2312 OW HOH 636 22.789 26.242 60.797 1.000 26.58ATOM 2313 OW HOH 637 7.008 -4.809 54.039 1.000 33.89ATOM 2314 OW HOH 638 -15.821 18.362 42.559 1.000 29.61ATOM 2315 OW HOH 639 -11.847 15.711 52.841 1.000 25.21ATOM 2316 OW HOH 640 -1.948 13.411 35.401 1.000 30.41ATOM 2317 OW HOH 641 -14.293 21.937 42.145 1.000 27.58ATOM 2318 OW HOH 642 18.216 20.839 66.863 1.000 31.23ATOM 2319 OW HOH 643 9.836 36.288 48.178 1.000 44.21ATOM 2320 OW H0H 644 3.510 16.168 66.253 1.000 33.82ATOM 2321 OW HOH 645 7.571 33.398 41.687 1.000 37.96ATOM 2322 OW HOH 646 0.780 21.844 36.729 1.000 31.71ATOM 2323 OW HOH 647 21.244 -2.321 35.579 1.000 32.40ATOM 2324 OW HOH 648 3.027 25.244 69.907 1.000 36.84ATOM 2325 OW HOH 649 1.129 25.273 66.516 1.000 35.42ATOM 2326 OW HOH 650 14.646 7.560 60.327 1.000 46.42ATOM 2327 OW HOH 651 -8.287 26.381 37.998 1.000 29.17ATOM 2328 OW HOH 652 10.153 23.548 67.703 1.000 31.50ATOM 2329 OW HOH 653 28.906 22.258 38.969 1.000 32.66ATOM 2330 OW HOH 654 13.568 -4.482 31.517 1.000 26.94ATOM 2331 OW HOH 655 -12.635 17.106 55.637 1.000 26.85ATOM 2332 OW HOH 656 2.698 5.770 50.702 1.000 29.05ATOM 2333 OW HOH 657 -1.384 7.487 46.512 1.000 36.52ATOM 2334 OW HOH 658 3.880 19.246 31.498 1.000 31.50ATOM 2335 OW HOH 659 -1.400 31.406 64.001 1.000 56.62ATOM 2336 OW HOH 660 11.416 23.260 65.229 1.000 32.69ATOM 2337 OW HOH 661 15.994 14.673 25.680 1.000 36.46ATOM 2338 OW HOH 662 28.572 21.242 53.423 1.000 39.06ATOM 2339 OW HOH 663 19.354 0.465 27.273 1.000 44.56ATOM 2340 OW HOH 664 24.969 27.026 38.838 1.000 35.41ATOM 2341 OW HOH 665 24.294 7.488 55.914 1.000 32.97ATOM 2342 OW HOH 666 19.540 7.882 31.178 1.000 30.04ATOM 2343 OW HOH 667 -9.236 32.988 57.241 1.000 39.20ATOM 2344 OW HOH 668 2.098 18.351 67.496 1.000 38.88ATOM 2345 OW HOH 669 11.390 3.245 56.270 1.000 37.56ATOM 2346 OW HOH 670 -21.413 24.449 52.026 1.000 44.66ATOM 2347 OW HOH 671 -14.575 19.220 55.240 1.000 30.91ATOM 2348 OW HOH 672 32.112 25.958 43.051 1.000 33.34ATOM 2349 OW HOH 673 -15.050 31.151 53.232 1.000 34.71ATOM 2350 OW HOH 674 2.941 -1.607 30.245 1.000 34.63ATOM 2351 OW HOH 675 26.951 14.544 34.757 1.000 49.17ATOM 2352 OW HOH 676 14.707 30.669 39.386 1.000 30.55ATOM 2353 OW HOH 677 5.203 18.009 68.080 1.000 43.41ATOM 2354 OW HOH 678 14.151 7.965 26.591 1.000 38.80ATOM 2355 OW HOH 679 24.470 24.261 41.443 1.000 31.28ATOM 2356 OW HOH 680 17.540 2.410 28.478 1.000 34.31ATOM 2357 OW HOH 681 25.992 20.593 34.326 1.000 39.66ATOM 2358 OW HOH 682 13.802 35.357 44.421 1.000 34.06ATOM 2359 OW HOH 683 1.087 2.355 45.456 1.000 35.39ATOM 2360 OW HOH 684 22.443 34.538 42.053 1.000 33.55ATOM 2361 OW HOH 685 4.419 4.720 27.356 1.000 48.02ATOM 2362 OW HOH 686 -15.830 34.507 51.877 1.000 50.63ATOM 2363 OW HOH 687 -15.217 29.490 48.887 1.000 33.54ATOM 2364 OW HOH 688 36.808 21.183 46.206 1.000 44.97ATOM 2365 OW HOH 689 3.756 1.312 29.272 1.000 35.16ATOM 2366 OW HOH 690 18.802 13.646 27.901 1.000 30.08ATOM 2367 OW HOH 691 6.997 17.521 29.313 1.000 47.70ATOM 2368 OW HOH 692 13.725 16.327 69.105 1.000 36.97ATOM 2369 OW HOH 693 22.369 22.161 60.503 1.000 44.09ATOM 2370 OW HOH 694 -5.429 31.620 42.219 1.000 33.40ATOM 2371 OW HOH 695 19.351 23.082 30.744 1.000 34.21ATOM 2372 OW HOH 696 6.897 22.414 29.376 1.000 36.59ATOM 2373 OW HOH 697 28.700 7.809 57.304 1.000 38.35ATOM 2374 OW HOH 698 3.224 0.679 39.819 1.000 24.13ATOM 2375 OW HOH 699 -4.634 33.717 62.593 1.000 32.26ATOM 2376 OW HOH 700 32.423 17.018 43.200 1.000 43.20ATOM 2377 OW HOH 701 12.119 25.228 68.342 1.000 39.95ATOM 2378 OW HOH 702 9.307 16.477 28.976 1.000 31.75ATOM 2379 OW HOH 703-11.313 34.067 46.117 1.000 49.40ATOM 2380 OW HOH 704 7.774 31.390 65.371 1.000 39.12ATOM 2381 OW HOH 705 24.764 7.530 36.802 1.000 38.55ATOM 2382 OW HOH 706 -22.095 25.669 59.047 1.000 36.71ATOM 2383 OW HOH 707 14.509 9.840 68.854 1.000 50.38ATOM 2384 OW HOH 708 -10.129 28.722 42.036 1.000 38.92ATOM 2385 OW HOH 709 29.011 34.910 48.390 1.000 35.29ATOM 2386 OW HOH 710 15.822 31.612 42.021 1.000 33.61ATOM 2387 OW HOH 711 -1.996 17.676 33.645 1.000 49.57ATOM 2388 OW HOH 712 10.216 17.748 26.015 1.000 41.04ATOM 2389 OW HOH 713 23.535 29.642 37.371 1.000 43.47ATOM 2390 OW HOH 714 20.488 -7.214 35.599 1.000 45.99ATOM 2391 OW HOH 715 11.411 10.149 25.081 1.000 41.63ATOM 2392 OW HOH 716 19.329 -4.258 34.139 1.000 42.50ATOM 2393 OW HOH 717 13.688 26.799 66.321 1.000 43.74ATOM 2394 OW HOH 718 -10.751 33.064 54.747 1.000 40.47ATOM 2395 OW HOH 719 13.800 18.258 70.756 1.000 34.54ATOM 2396 OW HOH 720 17.151 5.815 28.003 1.000 40.80ATOM 2397 OW HOH 721 0.000 0.000 36.691 0.330 27.42ATOM 2398 OW HOH 722 0.000 0.000 41.559 0.330 37.77ATOM 2399 OW HOH 723 15.314 7.549 28.791 1.000 36.24ATOM2400 OW HOH 724-1.663 19.944 39.1961.000 33.87ATOM2401 OW HOH 72519.289 24.195 33.3211.000 32.28ATOM2402 OW HOH 7260.000 0.000 31.7980.330 50.38ATOM2403 OW HOH 727-1.223 38.165 59.2291.000 31.24ATOM2404 OW HOH 72822.035 38.254 45.7421.000 48.21ATOM2405 OW HOH 72928.388 16.248 63.0441.000 31.59ATOM2406 OW HOH 7300.000 0.000 45.9950.330 36.14ATOM2407 OW HOH 7312.984 29.007 40.0911.000 36.08ATOM2408 OW HOH 7325.297 15.835 27.3181.000 41.53ATOM2409 OW HOH 73317.347 10.778 27.3731.000 35.27ATOM2410 OW HOH 73429.417 14.607 53.1271.000 40.12ATOM2411 OW HOH 7354.222 -8.636 27.0121.000 35.22ATOM2412 OW HOH 736-9.949 17.712 62.8131.000 34.43ATOM2413 OW HOH 73713.960 -10.203 55.2591.000 31.79ATOM2414 OW HOH 73811.831 -1.522 49.3081.000 25.22ATOM2415 OW HOH 7392.896 4.247 29.5961.000 38.64ATOM2416 OW HOH 74010.959 13.759 25.5281.000 61.86ATOM2417 OW HOH 7410.864 17.227 30.5571.000 50.71ATOM2418 OW HOH 74231.755 18.949 52.0651.000 40.48ATOM2419 OW HOH 74321.678 -0.485 28.2181.000 43.23ATOM2420 OW HOH 74410.583 16.397 75.2111.000 45.04ATOM2421 OW HOH 7457.480 7.996 78.2871.000 57.64ATOM2422 OW HOH 74624.067 35.122 40.2971.000 41.95ATOM2423 OW HOH 7477.804 10.269 78.3321.000 49.63ATOM2424 OW HOH 74822.131 40.645 45.8061.000 49.69ATOM2425 OW HOH 74914.850 -4.647 33.8721.000 42.88ATOM2426 OW HOH 750-12.930 32.504 55.2111.000 37.15ATOM2427 OW HOH 751-4.832 35.986 43.3331.000 44.39ATOM2428 OW HOH 75219.834 33.566 56.4491.000 31.56ATOM2429 OW HOH 7533.363 22.310 29.8441.000 42.02ATOM2430 OW HOH 75425.594 4.030 34.1741.000 51.90ATOM2431 OW HOH 75528.036 35.859 46.4481.000 39.50ATOM2432 OW HOH 756-12.951 16.294 61.7871.000 40.94ATOM2433 OW HOH 757-10.870 26.452 38.7371.000 44.85ATOM2434 OW HOH 75813.216 12.896 70.7291.000 63.42ATOM2435 OW HOH 759-0.403 21.161 74.9901.000 38.96ATOM2436 OW HOH 760-7.025 32.526 64.3161.000 39.64ATOM2437 OW HOH 761-15.459 19.739 58.0901.000 40.84ATOM2438 OW HOH 762-4.964 36.577 59.0681.000 48.64ATOM2439 OW HOH 76326.807 35.717 50.0361.000 43.54ATOM2440 OW HOH 76419.542 7.083 65.5381.000 41.41ATOM2441 OW HOH 7653.709 35.837 42.7091.000 33.78ATOM2442 OW HOH 7660.431 33.688 40.1721.000 36.91ATOM2443 OW HOH 76718.620 5.064 64.6171.000 45.76ATOM2444 OW HOH 76835.526 19.792 41.3221.000 52.54ATOM2445 OW HOH 76919.671 7.789 67.7171.000 43.44ATOM2446 OW HOH 7703.562 12.048 26.1491.000 40.08ATOM2447 OW HOH 77120.245 35.637 53.9271.000 52.16ATOM2448 OW HOH 772-20.588 25.640 61.5731.000 58.60ATOM2449 OW HOH 7731.556 37.342 52.1711.000 36.23ATOM2450 OW HOH 7748.340 0.668 49.3821.000 107.24ATOM2451 OW HOH 77527.160 2.372 34.4661.000 59.84ATOM2452 OW HOH 7766.575 19.271 25.5451.000 36.68ATOM 2453 OW HOH 777 -17.605 29.205 62.6611.000 56.83ATOM 2454 OW HOH 778 7.616 6.902 24.7221.000 61.34ATOM 2455 OW HOH 779 19.749 10.700 68.0061.000 65.22ATOM 2456 WHOH 780 7.281 -5.270 50.0901.000 50.00ATOM 2457 WHOH 781 -6.809 28.483 40.5151.000 50.00ATOM 2458 WHOH 782 9.990 17.263 38.6361.000 50.00ATOM 2459 WHOH 783 5.767 -2.331 28.9391.000 50.00ATOM 2460 WHOH 784 11.694 -0.118 24.9841.000 50.00ATOM 2461 WHOH 785 24.442 7.952 47.9941.000 50.00ATOM 2462 WHOH 786 14.251 36.889 46.4911.000 50.00ATOM 2463 WHOH 787 5.759 26.477 33.8511.000 50.00ATOM 2464 WHOH 788 -11.816 22.606 40.7951.000 50.00ATOM 2465 WHOH 789 -2.531 5.579 45.8291.000 50.00ATOM 2466 WHOH 790 -13.002 32.034 46.6121.000 50.00ATOM 2467 WHOH 791 2.230 3.555 48.9851.000 50.00ATOM 2468 WHOH 792 9.397 13.464 28.1211.000 50.00ATOM 2469 WHOH 793 28.257 10.442 42.7811.000 50.00ATOM 2470 WHOH 794 4.652 17.944 59.2411.000 50.00ATOM 2471 WHOH 795 5.977 15.287 79.5541.000 50.00ATOM 2472 WHOH 796 30.501 11.852 47.6161.000 50.00ATOM 2473 WHOH 797 5.625 14.258 54.3671.000 50.00ATOM 2474 WHOH 798 23.942 20.228 33.2771.000 50.00ATOM 2475 WHOH 799 10.164 14.642 58.9971.000 50.00ATOM 2476 WHOH 800 7.807 31.943 52.9991.000 50.00ATOM 2477 WHOH 801 23.377 9.361 34.8171.000 50.00ATOM 2478 WHOH 802 21.193 9.722 32.0041.000 50.00ATOM 2479 WHOH 803 34.928 14.644 46.0381.000 50.00ATOM 2480 WHOH 804 29.073 16.684 34.4451.000 50.00ATOM 2481 WHOH 805 7.008 -2.049 51.8721.000 50.00ATOM 2482 WHOH 806 25.363 7.860 45.5311.000 50.00ATOM 2483 WHOH 807 30.704 8.207 55.9711.000 50.00ATOM 2484 WHOH 808 33.072 24.900 40.5991.000 50.00ATOM 2485 WHOH 809 -15.577 19.225 63.1521.000 50.00ATOM 2486 WHOH 810 6.072 18.137 23.6031.000 50.00ATOM 2487 WHOH 811 -7.214 39.940 55.6391.000 50.00ATOM 2488 WHOH 812 5.509 18.517 74.9191.000 50.00ATOM 2489 WHOH 813 33.845 9.908 56.6721.000 50.00ATOM 2490 WHOH 814 0.421 35.779 42.9311.000 50.00ATOM 2491 WHOH 815 35.282 21.705 48.6561.000 50.00ATOM 2492 WHOH 816 39.344 22.173 46.8711.000 50.00ATOM 2493 WHOH 817 -5.192 39.820 60.0561.000 50.00ATOM 2494 WHOH 818 30.199 13.039 33.3831.000 50.00ATOM 2495 WHOH 819 -4.860 36.454 61.7311.000 50.00ATOM 2496 WHOH 820 -14.599 17.407 58.3821.000 50.00ATOM 2497 WHOH 821 1.340 -0.111 41.7110.500 50.00ATOM 2498 WHOH 822 34.512 23.218 52.1081.000 50.00ATOM 2499 WHOH 823 32.136 12.571 52.1901.000 50.00ATOM 2500 WHOH 824 13.525 -6.549 29.8381.000 50.00ATOM 2501 WHOH 825 6.072 -4.141 27.5341.000 50.00
结构BATOM1 CB MET 131.030 11.88257.0661.000 50.96ANISOU 1 CB MET 156633892 9809 1113 -2217 -554ATOM2 CG MET 130.206 12.69056.0861.000 51.63ANISOU 2 CG MET 165953775 9246 691-1891 169ATOM3 SD MET 128.694 11.84855.5591.000 40.50ANISOU 3 SD MET 170033962 4424 833-1535 -460ATOM4 CE MET 127.852 11.58457.1201.000 45.32ANISOU 4 CE MET 186323912 4677 -239 -653 -1702ATOM5 C MET 131.587 13.36758.9991.000 52.14ANISOU 5 C MET 162044752 8854 287-2128 -63ATOM6 O MET 131.239 12.84760.0581.000 52.92ANISOU 6 O MET 173815242 7483 1417 -4224 519ATOM7 N MET 133.170 11.64658.2751.000 57.78ANISOU 7 N MET 145336034 11388 34 -1912 -811ATOM8 CA MET 132.156 12.58757.8191.000 54.62ANISOU 8 CA MET 164414752 9560 137-2012 -617ATOM9 N ASP 231.485 14.67958.7921.000 43.52ANISOU 9 N ASP 234604866 8210 474-2350 47ATOM10CA ASP 230.759 15.47159.7961.000 41.69ANISOU 10CA ASP 244394678 6722 -309 -2603 -31ATOM11CB ASP 231.206 16.91259.6441.000 37.89ANISOU 11CB ASP 238054768 5822 -304 -3473 266ATOM12CG ASP 230.219 17.95860.1211.000 39.59ANISOU 12CG ASP 245114616 5916 15 -3218 589ATOM13OD1ASP 229.325 17.63760.9331.000 45.10ANISOU 13OD1ASP 258664689 6581 -553 -1950 -625ATOM14OD2ASP 230.363 19.12159.6631.000 42.05ANISOU 14OD2ASP 259944341 5643 -465 -3788 145ATOM15C ASP 229.275 15.21359.5561.000 33.84ANISOU 15C ASP 241313634 5094 -59-1682 -122ATOM16O ASP 228.901 15.17658.3791.000 29.25ANISOU 16O ASP 222324393 4489 658-390 -615ATOM17N THR 328.467 15.02960.5971.000 29.41ANISOU 17N THR 347312636 3807 907-2076 -284ATOM18CA THR 327.046 14.76460.4211.000 28.55ANISOU 18CA THR 346022494 3753 597-1006 -390ATOM19CB THR 326.447 13.76261.4141.000 36.51ANISOU 19CB THR 371702209 4495 -791 -1996 52ATOM20OG1THR 326.629 14.22062.7581.000 42.45ANISOU 20OG1THR 395192620 3989 -920 -1251 383ATOM21CG2THR 327.153 12.41261.3151.000 50.26ANISOU 21CG2THR 396041863 7630 -602 -733 -333ATOM22C THR 326.240 16.06160.5531.000 29.01ANISOU 22C THR 345352548 3939 738-1079 99ATOM23O THR 325.041 16.04460.8271.000 35.82ANISOU 23O THR 351492485 5976 390524 -1246ATOM24N THR 426.928 17.18160.3321.000 24.98ANISOU 24N THR 438742456 3162 542-2040 -986ATOM25CA THR 426.214 18.46560.3271.000 23.97ANISOU 25CA THR 434372426 3244 344-1563 -375ATOM26CB THR 427.183 19.65060.4081.000 26.77ANISOU 26CB THR 426362429 5105 651-988 -923ATOM27OG1THR 428.050 19.48461.5511.000 32.62ANISOU 27OG1THR 433982812 6184 195-2081 -1134ATOM28CG2THR 426.429 20.94260.6631.000 26.40ANISOU 28CG2THR 423732692 4967 533-573 -1570ATOM29C THR 425.325 18.57759.0971.000 21.64ANISOU 29C THR 430902760 2374 368-750 -20ATOM30O THR 425.738 18.26457.9801.000 21.58ANISOU 30O THR 426682629 2902 246-560 -659ATOM31N VAL 524.104 19.04959.3401.000 15.88ANISOU 31 N VAL 5 25052021 1508 -613 -630 -162ATOM32 CA VAL 5 23.211 19.38558.2111.000 14.80ANISOU 32 CA VAL 5 24631893 1266 -594 -473 -87ATOM33 CB VAL 5 21.742 19.40258.6061.000 16.09ANISOU 33 CB VAL 5 24761881 1757 -412 -406 502ATOM34 CG1 VAL 5 20.855 19.84657.4471.000 14.91ANISOU 34 CG1 VAL 5 24681859 1337 9 -102 197ATOM35 CG2 VAL 5 21.310 17.99459.0741.000 21.15ANISOU 35 CG2 VAL 5 30152345 2677 -700 -418 1198ATOM36 C VAL 5 23.639 20.76257.6941.000 17.70ANISOU 36 C VAL 5 28932085 1749 -1137 -713 103ATOM37 O VAL 5 23.532 21.75958.4191.000 17.35ANISOU 37 O VAL 5 25661978 2050 -698 -650 105ATOM38 N PRO 6 24.150 20.84556.4791.000 13.23ANISOU 38 N PRO 6 13341597 2097 -162 -668 409ATOM39 CD PRO 6 24.302 19.77055.4841.000 15.56ANISOU 39 CD PRO 6 18871850 2176 -309 -383 277ATOM40 CA PRO 6 24.667 22.13756.0051.000 14.49ANISOU 40 CA PRO 6 13321740 2432 -218 -536 522ATOM41 CB PRO 6 25.571 21.72254.8471.000 18.21ANISOU 41 CB PRO 6 22941740 2886 -224 130 434ATOM42 CG PRO 6 25.132 20.37854.4091.000 20.37ANISOU 42 CG PRO 6 27082632 2399 -1078 38 -61ATOM43 C PRO 6 23.576 23.09155.5101.000 14.59ANISOU 43 C PRO 6 13881712 2443 -406 -786 698ATOM44 O PRO 6 22.408 22.74355.2951.000 13.06ANISOU 44 O PRO 6 12981547 2118 -283 -596 15ATOM45 N THR 7 24.048 24.32655.3131.000 14.56ANISOU 45 N THR 7 13931678 2463 -380 -565 587ATOM46 CA THR 7 23.288 25.42854.7711.000 13.28ANISOU 46 CA THR 7 14631584 1998 -469 -734 440ATOM47 CB THR 7 23.121 26.57255.7991.000 14.44ANISOU 47 CB THR 7 19271652 1905 -348 -1257 329ATOM48 OG1 THR 7 22.454 26.10256.9981.000 18.44ANISOU 48 OG1 THR 7 31362013 1858 -333 -829 176ATOM49 CG2 THR 7 22.290 27.71955.2611.000 14.98ANISOU 49 CG2 THR 7 13901788 2513 -213 -727 412ATOM50 C THR 7 23.973 26.00553.5391.000 14.62ANISOU 50 C THR 7 11442200 2212 -355 -693 704ATOM51 O THR 7 25.192 26.25753.6001.000 17.21ANISOU 51 O THR 7 12842515 2738 -641 -840 975ATOM52 N PHE 8 23.211 26.22252.4721.000 12.32ANISOU 52 N PHE 8 11651596 1919 -314 -534 370ATOM53 CA PHE 8 23.692 26.86951.2831.000 13.31ANISOU 53 CA PHE 8 15541531 1971 -60-295 343ATOM54 CB PHE 8 23.724 25.93350.0671.000 13.71ANISOU 54 CB PHE 8 14791705 2025 -136 -232 234ATOM55 CG PHE 8 24.635 24.74650.2581.000 13.68ANISOU 55 CG PHE 8 12251716 2257 -185 8155ATOM56 CD1 PHE 8 24.147 23.50350.6281.000 14.10ANISOU 56 CD1 PHE 8 13171710 2329 -93231 221ATOM57 CD2 PHE 8 26.006 24.88250.0791.000 17.52ANISOU 57 CD2 PHE 8 12392282 3134 -234 -56 917ATOM58 CE1 PHE 8 24.984 22.42050.8121.000 15.39ANISOU 58 CE1 PHE 8 14731878 2497 -11242 481ATOM59 CE2 PHE 8 26.840 23.80750.2711.000 17.73ANISOU 59 CE2 PHE 8 11792259 3301 -157 -143 423ATOM60 CZ PHE 8 26.348 22.56750.6541.000 17.12ANISOU 60 CZ PHE 8 13102437 2757 24 -382 978ATOM61 C PHE 8 22.821 28.07350.9091.000 12.76ANISOU 61 C PHE 8 14011513 1935 -164 -145 442ATOM62 O PHE 8 21.60228.03351.079 1.000 13.18ANISOU 62 O PHE 8 1392 1295 2322 -256 -400 364ATOM63 N SER 9 23.47829.09650.394 1.000 13.03ANISOU 63 N SER 9 1722 1636 1593 -565 -601 490ATOM64 CASER 9 22.86130.22449.718 1.000 12.55ANISOU 64 CASER 9 1591 1468 1708 -392 -438 315ATOM65 CBSER 9 23.74331.47249.761 1.000 15.41ANISOU 65 CBSER 9 2385 1833 1637 -915 -1057 783ATOM66 OGSER 9 23.13832.53949.007 1.000 17.99ANISOU 66 OGSER 9 2504 1721 2611 -718 -999 924ATOM67 C SER 9 22.52029.86848.276 1.000 12.72ANISOU 67 C SER 9 2040 1187 1606 -411 -576 476ATOM68 O SER 9 23.39729.49547.478 1.000 16.18ANISOU 68 O SER 9 2265 2053 1830 -465 -381 73ATOM69 N LEU 10 21.22929.98247.968 1.000 14.19ANISOU 69 N LEU 10 2154 1488 1750 -301 -699 174ATOM70 CALEU 10 20.79829.71446.596 1.000 14.62ANISOU 70 CALEU 10 2243 1579 1734 -184 -784 224ATOM71 CBLEU 10 19.29129.88346.436 1.000 14.72ANISOU 71 CBLEU 10 2222 1714 1657 -142 -657 -168ATOM72 CGLEU 10 18.69329.63345.050 1.000 14.10ANISOU 72 CGLEU 10 2087 1557 1713 -702 -695 145ATOM73 CD1 LEU 10 18.98628.21444.582 1.000 16.23ANISOU 73 CD1 LEU 10 2994 1578 1595 -554 -1132 87ATOM74 CD2 LEU 10 17.19829.91344.997 1.000 21.82ANISOU 74 CD2 LEU 10 2180 2904 3206 -421 -1151 -518ATOM75 C LEU 10 21.53130.63945.626 1.000 15.87ANISOU 75 C LEU 10 2449 1785 1796 -491 -844 314ATOM76 O LEU 10 21.96230.19944.553 1.000 16.33ANISOU 76 O LEU 10 2607 1816 1780 -601 -829 276ATOM77 N ALA 11 21.66931.91745.986 1.000 17.17ANISOU 77 N ALA 11 2521 1889 2115 -607 -548 139ATOM78 CAALA 11 22.33532.91245.129 1.000 16.56ANISOU 78 CAALA 11 2377 1884 2029 -732 -1033 302ATOM79 CBALA 11 22.19934.25945.805 1.000 20.05ANISOU 79 CBALA 11 3210 1877 2529 -670 -674 259ATOM80 C ALA 11 23.78632.53544.831 1.000 16.33ANISOU 80 C ALA 11 2319 2255 1629 -754 -988 434ATOM81 O ALA 11 24.26032.58743.677 1.000 19.66ANISOU 81 O ALA 11 3115 2559 1795 -947 -560 619ATOM82 N GLU 12 24.55832.08545.810 1.000 17.28ANISOU 82 N GLU 12 2686 1994 1884 -454 -1087 390ATOM83 CAGLU 12 25.93131.65445.752 1.000 16.34ANISOU 83 CAGLU 12 2703 1674 1831 -474 -889 1033ATOM84 CBGLU 12 26.52731.4777.158 1.000 16.09ANISOU 84 CBGLU 12 2440 1867 1808 -770 -820 1058ATOM85 CGGLU 12 26.63332.80247.915 1.000 18.90ANISOU 85 CGGLU 12 2717 2127 2335 -1216 -1090 788ATOM86 CDGLU 12 27.11532.65749.342 1.000 21.17ANISOU 86 CDGLU 12 3300 2547 2198 -1182 -1053 724ATOM87 OE1 GLU 12 27.53831.55849.756 1.000 22.07ANISOU 87 OE1 GLU 12 2722 3014 2650 -720 -1365 797ATOM88 OE2 GLU 12 27.06833.67950.059 1.000 29.26ANISOU 88 OE2 GLU 12 5764 2634 2722 -1279 -1848 476ATOM89 C GLU 12 25.99730.40244.882 1.000 17.16ANISOU 89 C GLU 12 2044 2319 2158 -624 -715 481ATOM90 O GLU 12 26.87930.31744.032 1.000 18.88ANISOU 90 O GLU 12 3200 2388 1583 -1004 -306 899ATOM91 N LEU 13 25.08329.44145.049 1.000 17.32ANISOU 91 N LEU 13 2176 2300 2104 -659 -386 94ATOM92 CALEU 13 25.08228.25244.189 1.000 14.00ANISOU 92CALEU13 1734 1873 1713 -140 -170 498ATOM93CBLEU13 24.00327.24844.6201.000 15.37ANISOU 93CBLEU13 2205 1838 1795 -375 -149 465ATOM94CGLEU13 24.15426.55445.9671.000 14.52ANISOU 94CGLEU13 1913 1803 1799 -280 -204 442ATOM95CD1 LEU13 22.93425.68046.1931.000 15.15ANISOU 95CD1 LEU13 2174 1817 1766 -433 185 175ATOM96CD2 LEU13 25.41125.69046.0671.000 17.54ANISOU 96CD2 LEU13 2119 2043 2502 -38-419 270ATOM97C LEU13 24.87628.62642.7251.000 16.54ANISOU 97C LEU13 2510 2062 1710 -222 -93 565ATOM98O LEU13 25.54828.12241.8211.000 18.28ANISOU 98O LEU13 2685 2514 1748 -687 75259ATOM99N GLN14 23.94529.53442.4721.000 16.86ANISOU 99N GLN14 1970 2337 2100 -557 -683 838ATOM100 CAGLN14 23.65730.01541.1321.000 18.63ANISOU 100 CAGLN14 2761 2404 1915 -610 -802 568ATOM101 CBGLN14 22.42130.92341.1301.000 19.39ANISOU 101 CBGLN14 3166 2176 2025 -392 -918 977ATOM102 CGGLN14 21.10830.25041.4601.000 19.00ANISOU 102 CGGLN14 2879 2383 1957 -209 -725 460ATOM103 CDGLN14 19.97431.22741.7661.000 18.83ANISOU 103 CDGLN14 3139 2118 1897 -6 -1229 494ATOM104 OE1 GLN14 20.17732.31742.3141.000 26.10ANISOU 104 OE1 GLN14 3928 2407 3582 -98-1172 -241ATOM105 NE2 GLN14 18.74530.82341.4111.000 20.94ANISOU 105 NE2 GLN14 2900 2716 2340 -149 -840 454ATOM106 C GLN14 24.80430.81240.5251.000 20.40ANISOU 106 C GLN14 3226 2458 2065 -795 -712 937ATOM107 O GLN14 24.81230.95139.3111.000 30.48ANISOU 107 O GLN14 5089 4340 2152 -2337 -898 1211ATOM108 N GLN15 25.73431.30941.3291.000 20.35ANISOU 108 N GLN15 3252 2452 2030 -1067 -240 497ATOM109 CAGLN15 26.90932.04140.8841.000 21.88ANISOU 109 CAGLN15 3184 3230 1901 -1152 -299 788ATOM110 CBGLN15 27.28833.10041.9201.000 22.20ANISOU 110 CBGLN15 2720 3162 2551 -1131 -770 691ATOM111 CGGLN15 26.45034.35841.9541.000 25.73ANISOU 111 CGGLN15 4496 2735 2545 -821 -233 1269ATOM112 CDGLN15 26.32535.02143.3061.000 35.76ANISOU 112 CDGLN15 6010 3945 3631 -643 -229 -135ATOM113 OE1 GLN15 27.14534.88444.2251.000 49.13ANISOU 113 OE1 GLN15 8425 5866 4378 -2857 -2197 -564ATOM114 NE2 GLN15 25.25535.81243.4891.000 51.85ANISOU 114 NE2 GLN15 7190 5567 6945 62 3066 107ATOM115 C GLN15 28.06931.07940.6251.000 23.93ANISOU 115 C GLN15 3451 3513 2127 -990 145 884ATOM116 O GLN15 29.17731.44840.2131.000 28.95ANISOU 116 O GLN15 3535 4619 2845 -899 510 1225ATOM117 N GLY16 27.82829.79440.8911.000 25.86ANISOU 117 N GLY16 4089 3282 2457 -889 -36 469ATOM118 CAGLY16 28.81228.76340.6491.000 29.00ANISOU 118 CAGLY16 4785 3562 2671 -677 765 255ATOM119 C GLY16 29.74128.54641.8141.000 25.45ANISOU 119 C GLY16 3427 3490 2754 -264 1422 673ATOM120 O GLY16 30.80527.95541.6251.000 29.63ANISOU 120 O GLY16 3925 3267 4068 -661997 523ATOM121 N LEU17 29.38728.97943.0151.000 22.50ANISOU 121 N LEU17 3266 2713 2569 -39923 733ATOM122 CALEU17 30.23428.72744.1721.000 21.73ANISOU 122 CALEU17 2299 2931 3025 -282 867 748ATOM123 CB LEU17 30.124 29.92145.1321.000 21.23ANISOU 123 CB LEU17 21372858 3071 -620 669 711ATOM124 CG LEU17 30.354 31.27444.4311.000 26.12ANISOU 124 CG LEU17 27082965 4253 -889 1342 931ATOM125 CD1 LEU17 29.962 32.44445.3051.000 29.81ANISOU 125 CD1 LEU17 25152924 5885 -396 464 303ATOM126 CD2 LEU17 31.808 31.35043.9741.000 32.84ANISOU 126 CD2 LEU17 28453703 5930 -281 1871 2114ATOM127 CLEU17 29.886 27.45644.9361.000 19.36ANISOU 127 CLEU17 20812819 2455 -239 545 580ATOM128 OLEU17 28.773 26.92044.8481.000 21.11ANISOU 128 OLEU17 22843004 2734 -444 107 1055ATOM129 NHIS18 30.838 26.95245.7061.000 21.02ANISOU 129 NHIS18 21242752 3109 -314 193 491ATOM130 CA HIS18 30.678 25.81446.6151.000 18.11ANISOU 130 CA HIS18 15692996 2315 -460 -28 361ATOM131 CB HIS18 29.655 26.14947.7021.000 21.25ANISOU 131 CB HIS18 17313332 3010 -45282 354ATOM132 CG HIS18 29.796 27.51548.2831.000 23.28ANISOU 132 CG HIS18 22343612 2999 211-46 -20ATOM133 CD2 HIS18 28.898 28.53548.3441.000 24.53ANISOU 133 CD2 HIS18 31123479 2728 53241440ATOM134 ND1 HIS18 30.940 27.97748.8951.000 26.72ANISOU 134 ND1 HIS18 29384039 3173 -151 -569 38ATOM135 CE1 HIS18 30.756 29.21849.3071.000 29.80ANISOU 135 CE1 HIS18 44763775 3071 -542 -562 237ATOM136 NE2 HIS18 29.524 29.58148.9851.000 30.03ANISOU 136 NE2 HIS18 47523282 3377 216-148 338ATOM137 CHIS18 30.266 24.52845.9171.000 18.57ANISOU 137 CHIS18 19433084 2028 -951 30590ATOM138 OHIS18 29.594 23.68246.5321.000 19.92ANISOU 138 OHIS18 19493125 2493 -777 -87 995ATOM139 NGLN19 30.647 24.34044.6581.000 19.24ANISOU 139 NGLN19 23292700 2282 -256 298 494ATOM140 CA GLN19 30.119 23.20643.9081.000 21.51ANISOU 140 CA GLN19 32492431 2492 -228 597 318ATOM141 CB GLN19 30.446 23.30742.4061.000 22.89ANISOU 141 CB GLN19 32313058 2408 -148 463 244ATOM142 CG GLN19 29.738 24.45341.6981.000 25.83ANISOU 142 CG GLN19 34453712 2658 -384 -407 568ATOM143 CD GLN19 28.223 24.47041.7471.000 31.56ANISOU 143 CD GLN19 34394722 3832 -252 -988 357ATOM144 OE1 GLN19 27.521 23.64041.1531.000 38.51ANISOU 144 OE1 GLN19 38693649 7115 377-3045 686ATOM145 NE2 GLN19 27.621 25.43342.4751.000 33.32ANISOU 145 NE2 GLN19 33035695 3663 647-1109 449ATOM146 CGLN19 30.578 21.87344.4851.000 20.32ANISOU 146 CGLN19 22242710 2785 -60514 394ATOM147 OGLN19 29.806 20.90044.4731.000 19.08ANISOU 147 OGLN19 18882451 2910 221257 743ATOM148 NASP20 31.800 21.76144.9991.000 24.09ANISOU 148 NASP20 30013507 2645 -773 -507 415ATOM149 CA ASP20 32.268 20.49845.5531.000 21.82ANISOU 149 CA ASP20 17073811 2774 -327 -58 357ATOM150 CB ASP20 33.780 20.52745.7791.000 26.34ANISOU 150 CB ASP20 15944552 3863 -962 236 490ATOM151 CG ASP20 34.596 20.51744.5031.000 34.45ANISOU 151 CG ASP20 25315859 4701 -1208 1213 -280ATOM152 OD1 ASP20 34.177 19.98243.4571.000 33.11ANISOU 152 OD1 ASP20 37684173 4640 -311 1233 -375ATOM153 OD2 ASP20 35.725 21.05644.5321.000 49.71ANISOU 153 OD2 ASP 20 34459922 5519 -3116 1710 53ATOM154 CASP 20 31.538 20.17946.8621.000 21.03ANISOU 154 CASP 20 18762702 3412 -231 616 388ATOM155 OASP 20 31.118 19.03847.0751.000 20.80ANISOU 155 OASP 20 11622583 4157 -72-139 550ATOM156 NGLU 21 31.359 21.17747.7291.000 17.88ANISOU 156 NGLU 21 12182751 2824 -263 -148 511ATOM157 CA GLU 21 30.599 20.99948.9651.000 16.80ANISOU 157 CA GLU 21 11282173 3083 -9646394ATOM158 CB GLU 21 30.654 22.30449.7811.000 20.23ANISOU 158 CB GLU 21 13662620 3701 5 -262 -210ATOM159 CG GLU 21 32.040 22.66950.3071.000 24.60ANISOU 159 CG GLU 21 16603325 4359 -221 -654 -301ATOM160 CD GLU 21 32.860 23.56549.4021.000 28.46ANISOU 160 CD GLU 21 11914348 5275 -498 -1597 1125ATOM161 OE1 GLU 21 33.751 24.29449.9191.000 31.17ANISOU 161 OE1 GLU 21 23604428 5057 -1039 -1094 349ATOM162 OE2 GLU 21 32.664 23.59048.1711.000 31.16ANISOU 162 OE2 GLU 21 27343901 5203 -1519 -1565 1123ATOM163 CGLU 21 29.159 20.59448.6891.000 16.44ANISOU 163 CGLU 21 12712295 2679 -165 -53 430ATOM164 OGLU 21 28.599 19.70049.3291.000 14.30ANISOU 164 OGLU 21 12712257 1907 -417 -301 36ATOM165 NPHE 22 28.548 21.25747.7081.000 16.14ANISOU 165 NPHE 22 14402441 2253 -316 -28 328ATOM166 CA PHE 22 27.155 20.94747.3271.000 15.36ANISOU 166 CA PHE 22 15302012 2294 -262 -173 281ATOM167 CB PHE 22 26.612 21.96746.3431.000 15.43ANISOU 167 CB PHE 22 18632056 1944 -316 -247 184ATOM168 CG PHE 22 25.119 21.93246.0771.000 15.59ANISOU 168 CG PHE 22 18222141 1962 -299 -170 561ATOM169 CD1 PHE 22 24.218 21.98747.1291.000 17.03ANISOU 169 CD1 PHE 22 19232605 1943 -410 -162 -40ATOM170 CD2 PHE 22 24.606 21.85644.7971.000 14.84ANISOU 170 CD2 PHE 22 15412083 2013 51 -94 -155ATOM171 CE1 PHE 22 22.861 21.93846.9061.000 15.96ANISOU 171 CE1 PHE 22 18441805 2414 -159 -64 176ATOM172 CE2 PHE 22 23.243 21.79744.5511.000 15.81ANISOU 172 CE2 PHE 22 16001993 2416 -261 -190 -176ATOM173 CZ PHE 22 22.360 21.85345.6121.000 14.18ANISOU 173 CZ PHE 22 14271430 2531 -105 -164 325ATOM174 CPHE 22 27.049 19.51546.7921.000 16.23ANISOU 174 CPHE 22 13252042 2797 -110 164 102ATOM175 OPHE 22 26.183 18.75147.2291.000 13.24ANISOU 175 OPHE 22 14111743 1876 105-194 391ATOM176 NARG 23 27.888 19.09745.8531.000 15.45ANISOU 176 NARG 23 15852313 1971 -167 -80 289ATOM177 CA ARG 23 27.865 17.74645.3251.000 15.49ANISOU 177 CA ARG 23 809 2443 2634 50 -41 -22ATOM178 CB ARG 23 28.928 17.53944.2481.000 17.81ANISOU 178 CB ARG 23 966 3142 2658 -128 43-167ATOM179 CG ARG 23 28.470 17.92842.8601.000 25.86ANISOU 179 CG ARG 23 27194636 2470 -758 -176 -49ATOM180 CD ARG 23 29.485 17.37041.8671.000 34.68ANISOU 180 CD ARG 23 51484847 3183 -1532 1634 -548ATOM181 NE ARG 23 30.660 18.25341.8771.000 31.13ANISOU 181 NE ARG 23 27994194 4836 305747 66ATOM182 CZ ARG 23 30.703 19.42441.2441.000 34.24ANISOU 182 CZ ARG 23 27494844 5418 -757 239 764ATOM183 NH1 ARG 23 29.647 19.85640.5511.000 28.06ANISOU 183 NH1 ARG 23 27143685 4263 -721 555 181ATOM 184 NH2 ARG23 31.830 20.11441.3401.000 36.08ANISOU 184 NH2 ARG23 22615328 6121 -562 776 -86ATOM 185 C ARG23 28.045 16.71346.4201.000 15.06ANISOU 185 C ARG23 10712061 2589 167-32 -234ATOM 186 O ARG23 27.335 15.68746.4101.000 16.28ANISOU 186 O ARG23 14432244 2497 -118 -71 -277ATOM 187 N ARG24 28.952 16.98847.3531.000 15.27ANISOU 187 N ARG24 10242156 2623 -52-21 29ATOM 188 CA ARG24 29.193 16.00348.4301.000 17.70ANISOU 188 CA ARG24 14432589 2693 275-2215ATOM 189 CB ARG24 30.466 16.42249.1481.000 21.11ANISOU 189 CB ARG24 12443486 3289 484-257 384ATOM 190 CG ARG24 31.787 16.21748.4291.000 30.46ANISOU 190 CG ARG24 14385078 5057 426441 308ATOM 191 CD ARG24 32.979 16.53749.3301.000 33.50ANISOU 191 CD ARG24 11635831 5736 208370 458ATOM 192 NE ARG24 33.636 17.80449.0711.000 51.46ANISOU 192 NE ARG24 58007316 6437 -2596 -1688 1165ATOM 193 CZ ARG24 33.973 18.77649.9031.000 46.72ANISOU 193 CZ ARG24 47386888 6124 -1719 -1822 1316ATOM 194 NH1 ARG24 33.731 18.72851.2131.000 44.24ANISOU 194 NH1 ARG24 26506998 7160 -392 1001 84ATOM 195 NH2 ARG24 34.579 19.87149.4481.000 42.82ANISOU 195 NH2 ARG24 53394428 6503 513-991 1216ATOM 196 C ARG24 27.972 15.88749.3341.000 17.16ANISOU 196 C ARG24 15492071 2900 129140 295ATOM 197 O ARG24 27.536 14.77949.7131.000 15.38ANISOU 197 O ARG24 17061890 2247 72 -388 104ATOM 198 N CYS25 27.355 17.01149.6961.000 12.91ANISOU 198 N CYS25 907 1824 2176 -254 -386 151ATOM 199 CA CYS25 26.105 17.04050.4541.000 12.45ANISOU 199 CA CYS25 942 1838 1949 -178 -480 81ATOM 200 CB CYS25 25.660 18.49150.6971.000 11.67ANISOU 200 CB CYS25 11501759 1527 -136 -604 184ATOM 201 SG CYS25 23.973 18.58051.4251.000 14.90ANISOU 201 SG CYS25 14651593 2602 -164 -26 -18ATOM 202 C CYS25 25.001 16.22549.7691.000 11.67ANISOU 202 C CYS25 893 1897 1645 -283 -64 -86ATOM 203 O CYS25 24.360 15.37750.3901.000 12.73ANISOU 203 O CYS25 13471426 2064 -233 -196 123ATOM 204 N LEU26 24.798 16.46148.4701.000 11.70ANISOU 204 N LEU26 11021530 1814 -128 -390 1ATOM 205 CA LEU26 23.766 15.71647.7351.000 11.11ANISOU 205 CA LEU26 11901476 1556 -238 -79 -194ATOM 206 CB LEU26 23.674 16.19846.2851.000 11.54ANISOU 206 CB LEU26 13451522 1518 -75-84 -202ATOM 207 CG LEU26 23.242 17.63846.0191.000 12.42ANISOU 207 CO LEU26 11991542 1978 -153 -167 -40ATOM 208 CD1 LEU26 23.414 17.99344.5391.000 14.77ANISOU 208 CD1 LEU26 14281916 2270 43 131 401ATOM 209 CD2 LEU26 21.814 17.88546.4661.000 14.45ANISOU 209 CD2 LEU26 13842061 2047 264-32 321ATOM 210 C LEU26 23.979 14.20947.7801.000 12.93ANISOU 210 C LEU26 13601542 2011 -121 -486 -107ATOM 211 O LEU26 23.011 13.46148.0081.000 13.78ANISOU 211 O LEU26 16601450 2125 -305 -426 -51ATOM 212 N ARG27 25.196 13.72147.5761.000 14.09ANISOU 212 N ARG27 15181729 2108 151-530 -105ATOM 213 CA ARG27 25.491 12.28347.5741.000 15.39ANISOU 213 CA ARG27 22601690 1897 186141 -354ATOM 214 CB ARG27 26.846 12.12246.9001.000 17.04ANISOU 214 CB ARG 27 22592356 1861 51749-248ATOM215 CG ARG 27 27.502 10.78046.8011.000 25.08ANISOU 215 CG ARG 27 31102837 3583 1105 606 -399ATOM216 CD ARG 27 28.995 10.99246.4571.000 30.32ANISOU 216 CD ARG 27 29763836 4710 1190 720 -1381ATOM217 NE ARG 27 29.818 11.40747.5811.000 36.51ANISOU 217 NE ARG 27 36334937 5301 121391 -1429ATOM218 CZ ARG 27 30.988 12.01947.5601.000 38.07ANISOU 218 CZ ARG 27 33345192 5941 364661 -1776ATOM219 NH1 ARG 27 31.565 12.34046.4011.000 48.56ANISOU 219 NH1 ARG 27 44827688 6280 -1305 736 -1326ATOM220 NH2 ARG 27 31.606 12.32848.7011.000 40.23ANISOU 220 NH2 ARG 27 28916127 6266 457717 -2463ATOM221 CARG 27 25.479 11.63048.9491.000 14.66ANISOU 221 CARG 27 17201617 2233 135-33 -42ATOM222 OARG 27 24.968 10.49949.0721.000 17.44ANISOU 222 OARG 27 19811533 3114 98 -394 155ATOM223 NASP 28 26.031 12.30849.9731.000 13.72ANISOU 223 NASP 28 17031366 2146 317-327 319ATOM224 CA ASP 28 26.227 11.70151.2771.000 15.33ANISOU 224 CA ASP 28 18861704 2234 538-247 391ATOM225 CB ASP 28 27.541 12.28051.8421.000 18.31ANISOU 225 CB ASP 28 20922709 2155 186-465 544ATOM226 CG ASP 28 28.785 11.87551.0831.000 23.06ANISOU 226 CG ASP 28 20023583 3176 -96-50 478ATOM227 OD1 ASP 28 28.741 10.90450.2901.000 25.09ANISOU 227 OD1 ASP 28 25152855 4163 830406 440ATOM228 OD2 ASP 28 29.831 12.52851.2831.000 30.05ANISOU 228 OD2 ASP 28 19194262 5236 -216 -695 1058ATOM229 CASP 28 25.092 11.91052.2671.000 14.90ANISOU 229 CASP 28 20711435 2154 411-203 217ATOM230 OASP 28 24.967 11.09353.2001.000 14.50ANISOU 230 OASP 28 18781501 2132 444-265 179ATOM231 NLYS 29 24.317 12.97552.0961.000 12.90ANISOU 231 NLYS 29 14871290 2126 77 -276 136ATOM232 CA LYS 29 23.265 13.36853.0291.000 12.95ANISOU 232 CA LYS 29 13691649 1904 8 -390 14ATOM233 CB LYS 29 23.699 14.65353.7631.000 12.71ANISOU 233 CB LYS 29 11051581 2145 209-359 -30ATOM234 CG LYS 29 25.016 14.50454.5181.000 16.11ANISOU 234 CG LYS 29 14131998 2711 21 -818 -161ATOM235 CD LYS 29 25.449 15.72755.3091.000 18.24ANISOU 235 CD LYS 29 25001989 2442 -47-1140 -14ATOM236 CE LYS 29 26.789 15.44556.0021.000 19.36ANISOU 236 CE LYS 29 20383171 2148 -90-822 -725ATOM237 NZ LYS 29 27.515 16.69656.3511.000 26.61ANISOU 237 NZ LYS 29 25923146 4373 -309 -1571 -353ATOM238 CLYS 29 21.888 13.55052.3861.000 11.62ANISOU 238 CLYS 29 14321153 1831 52 -290 24ATOM239 OLYS 29 20.877 13.02852.8801.000 12.57ANISOU 239 OLYS 29 14261556 1792 -97-282 100ATOM240 NGLY 30 21.779 14.28051.2841.000 11.98ANISOU 240 NGLY 30 13591454 1741 -5 -310 78ATOM241 CA GLY 30 20.510 14.47850.5621.000 10.93ANISOU 241 CA GLY 30 11921497 1465 -158 -116 -18ATOM242 CGLY 30 19.544 15.43351.2421.000 11.15ANISOU 242 CGLY 30 11371143 1955 -260 -154 -131ATOM243 OGLY 30 18.337 15.37450.9631.000 11.26ANISOU 243 OGLY 30 12471082 1949 -56-419 104ATOM244 NLEU 31 20.064 16.27852.1291.000 10.54ANISOU 244 NLEU 31 1292894 1821 -98-367 89ATOM 245 CA LEU 31 19.272 17.324 52.803 1.000 11.07ANISOU 245 CA LEU 31 1345 1111 175246 -520 -33ATOM 246 CB LEU 31 18.465 16.777 53.975 1.000 14.44ANISOU 246 CB LEU 31 1753 1671 2062-284 -80 -178ATOM 247 CG LEU 31 19.113 16.629 55.333 1.000 17.74ANISOU 247 CG LEU 31 2456 2220 2064-172 -115 499ATOM 248 CD1 LEU 31 18.220 15.978 56.371 1.000 26.19ANISOU 248 CD1 LEU 31 2716 4691 2543-1224 -213 1016ATOM 249 CD2 LEU 31 20.388 15.821 55.182 1.000 22.77ANISOU 249 CD2 LEU 31 3121 2633 2899650-18 1487ATOM 250 C LEU 31 20.176 18.498 53.195 1.000 10.95ANISOU 250 C LEU 31 1041 1129 1989180-318 -223ATOM 251 O LEU 31 21.376 18.314 53.424 1.000 10.89ANISOU 251 O LEU 31 1015 1171 952 69 -160 204ATOM 252 N PHE 32 19.570 19.688 53.219 1.000 11.42ANISOU 252 N PHE 32 1134 995221175 -273 65ATOM 253 CA PHE 32 20.280 20.916 53.545 1.000 10.33ANISOU 253 CA PHE 32 1071 1152 1703-57-288 -33ATOM 254 CB PHE 32 21.244 21.307 52.422 1.000 12.25ANISOU 254 CB PHE 32 1054 1729 1872-113 -173 -5ATOM 255 CG PHE 32 20.624 21.346 51.041 1.000 11.94ANISOU 255 CG PHE 32 1158 1572 1809-281 -148 122ATOM 256 CD1 PHE 32 20.522 20.188 50.270 1.000 11.12ANISOU 256 CD1 PHE 32 1070 1308 1846-182 -458 318ATOM 257 CD2 PHE 32 20.145 22.528 50.513 1.000 12.14ANISOU 257 CD2 PHE 32 1618 1353 1639-300 -185 -47ATOM 258 CE1 PHE 32 19.943 20.212 49.015 1.000 12.00ANISOU 258 CE1 PHE 32 1342 1377 1840-301 -468 332ATOM 259 CE2 PHE 32 19.553 22.534 49.266 1.000 12.79ANISOU 259 CE2 PHE 32 1858 1543 1457-86-34 28ATOM 260 CZ PHE 32 19.416 21.376 48.503 1.000 11.50ANISOU 260 CZ PHE 32 1623 1414 1331-76-272 217ATOM 261 C PHE 32 19.310 22.071 53.762 1.000 9.82ANISOU 261 C PHE 32 1015 1042 1674-120 -367 -77ATOM 262 O PHE 32 18.165 21.990 53.285 1.000 11.29ANISOU 262 O PHE 32 1097 1286 1906 -95-495 -77ATOM 263 N TYR 33 19.736 23.099 54.493 1.000 12.68ANISOU 263 N TYR 33 1606 1053 2158-57-766 -159ATOM 264 CA TYR 33 18.945 24.335 54.607 1.000 10.64ANISOU 264 CA TYR 33 1491 1173 1380-77-97 -132ATOM 265 CB TYR 33 19.141 25.022 55.955 1.000 10.85ANISOU 265 CB TYR 33 1019 1725 1379-260 -224 -164ATOM 266 CG TYR 33 18.545 24.331 57.156 1.000 10.71ANISOU 266 CG TYR 33 1173 1552 1342-45-230 -117ATOM 267 CD1 TYR 33 17.266 24.643 57.619 1.000 11.64ANISOU 267 CD1 TYR 33 1385 1441 1596-6883-94ATOM 268 CE1 TYR 33 16.694 24.023 58.719 1.000 13.60ANISOU 268 CE1 TYR 33 1879 1483 1804-147 339 -26ATOM 269 CD2 TYR 33 19.273 23.364 57.853 1.000 14.04ANISOU 269 CD2 TYR 33 1604 2040 1689132-509 127ATOM 270 CE2 TYR 33 18.711 22.752 58.964 1.000 15.75ANISOU 270 CE2 TYR 33 1872 2227 1886-187 -701 433ATOM 271 CZ TYR 33 17.438 23.078 59.387 1.000 16.02ANISOU 271 CZ TYR 33 2205 1939 1942-332 -154 300ATOM 272 OH TYR 33 16.919 22.454 60.504 1.000 19.95ANISOU 272 OH TYR 33 3412 2154 2015-60278 400ATOM 273 C TYR 33 19.357 25.253 53.452 1.000 10.92ANISOU 273 C TYR 33 1249 1448 1453-125 -271 149ATOM 274 O TYR 33 20.514 25.192 53.006 1.000 11.50ANISOU 274 O TYR 33 1204 1375 1791-98-270 281ATOM 275 N LEU 34 18.399 26.049 53.000 1.000 11.28ANISOU 275 N LEU 34 11591265 1862 -210 -149 121ATOM276 CA LEU 34 18.577 26.94251.8641.000 12.99ANISOU 276 CA LEU 34 15651444 1926 81 -478 274ATOM277 CB LEU 34 17.757 26.42050.6821.000 13.96ANISOU 277 CB LEU 34 20071301 1995 -430 -459 321ATOM278 CG LEU 34 17.990 27.11249.3341.000 13.81ANISOU 278 CG LEU 34 20851322 1839 -331 -365 198ATOM279 CD1LEU 34 19.308 26.69148.7041.000 15.94ANISOU 279 CD1LEU 34 21231793 2140 -10-313 607ATOM280 CD2LEU 34 16.818 26.79948.4111.000 16.36ANISOU 280 CD2LEU 34 21861837 2193 122-721 134ATOM281 C LEU 34 18.195 28.36152.2411.000 13.03ANISOU 281 C LEU 34 16761418 1857 31 -643 218ATOM282 O LEU 34 17.055 28.64752.5951.000 13.99ANISOU 282 O LEU 34 16901281 2344 140-714 85ATOM283 N THR 35 19.148 29.28352.1751.000 15.03ANISOU 283 N THR 35 18371584 2288 -118 -625 -3ATOM284 CA THR 35 18.918 30.70452.3691.000 14.80ANISOU 284 CA THR 35 18661560 2196 -169 -175 -144ATOM285 CB THR 35 20.013 31.36653.2321.000 15.65ANISOU 285 CB THR 35 20251719 2202 -149 -204 -281ATOM286 OG1THR 35 21.276 31.11552.6011.000 18.81ANISOU 286 OG1THR 35 18852679 2583 -279 -229 -728ATOM287 CG2THR 35 20.138 30.81154.6221.000 18.84ANISOU 287 CG2THR 35 25232207 2427 -850 -510 155ATOM288 C THR 35 18.915 31.45651.0431.000 15.07ANISOU 288 C THR 35 19041473 2348 -57-283 -70ATOM289 O THR 35 19.209 30.90949.9731.000 15.00ANISOU 289 O THR 35 20341520 2145 -215 -372 89ATOM290 N ASP 36 18.564 32.73951.0861.000 17.46ANISOU 290 N ASP 36 23021366 2968 -209 -766 -120ATOM291 CA ASP 36 18.618 33.60649.9241.000 17.91ANISOU 291 CA ASP 36 21501592 3063 112-660 86ATOM292 CB ASP 36 20.063 33.84549.4711.000 17.91ANISOU 292 CB ASP 36 21531584 3067 84 -587 -42ATOM293 CG ASP 36 20.948 34.54550.4691.000 19.23ANISOU 293 CG ASP 36 25752160 2571 -642 -324 181ATOM294 OD1ASP 36 20.426 35.30451.3251.000 24.17ANISOU 294 OD1ASP 36 28433055 3284 152-1013 -652ATOM295 OD2ASP 36 22.199 34.35550.4121.000 21.00ANISOU 295 OD2ASP 36 26372571 2772 -382 -834 -393ATOM296 C ASP 36 17.783 33.03848.7841.000 18.20ANISOU 296 C ASP 36 24021736 2779 -446 -390 191ATOM297 O ASP 36 18.222 33.06347.6291.000 18.98ANISOU 297 O ASP 36 21272022 3062 -464 -60 -252ATOM298 N CYS 37 16.593 32.54749.0771.000 17.22ANISOU 298 N CYS 37 18732190 2479 63 -350 -1ATOM299 CA CYS 37 15.730 31.94548.0431.000 15.98ANISOU 299 CA CYS 37 19971590 2485 -81-65 -184ATOM300 CB CYS 37 15.621 30.42348.2521.000 18.87ANISOU 300 CB CYS 37 21121790 3268 -114 -405 570ATOM301 SG CYS 37 14.753 29.91749.7591.000 19.42ANISOU 301 SG CYS 37 25321683 3164 -74-230 322ATOM302 C CYS 37 14.349 32.58047.9581.000 16.12ANISOU 302 C CYS 37 19921669 2465 -175 -504 16ATOM303 O CYS 37 13.483 32.03247.2531.000 20.60ANISOU 303 O CYS 37 27611769 3296 -241 -1333 51ATOM304 N GLY 38 14.125 33.71448.6171.000 17.89ANISOU 304 N GLY 38 18471572 3381 209-898 -111ATOM305 CA GLY 38 12.850 34.40448.5871.000 18.16ANISOU 305 CA GLY 38 16082126 3164 141-999 -6ATOM306 C GLY 38 11.843 33.86449.5891.000 21.98ANISOU 306 C GLY 38 25982574 3180 262-97 -455ATOM307 O GLY 38 10.677 34.27349.4991.000 22.75ANISOU 307 O GLY 38 25423027 3073 24179-97ATOM308 N LEU 39 12.241 32.98250.5011.000 21.93ANISOU 308 N LEU 39 21123318 2903 -65-102 -154ATOM309 CA LEU 39 11.443 32.35751.5451.000 26.16ANISOU 309 CA LEU 39 31413610 3188 -1071 162 -400ATOM310 CB LEU 39 11.220 30.86851.2771.000 28.13ANISOU 310 CB LEU 39 29803192 4516 -352 -848 258ATOM311 CG LEU 39 10.296 30.43450.1571.000 27.39ANISOU 311 CG LEU 39 33522591 4463 541-637 -1052ATOM312 CD1LEU 39 10.472 28.94049.9101.000 28.66ANISOU 312 CD1LEU 39 33752293 5221 581-150 -190ATOM313 CD2LEU 39 8.838 30.76850.4781.000 30.62ANISOU 313 CD2LEU 39 31552985 5496 1275 -1485 -208ATOM314 C LEU 39 12.060 32.43052.9491.000 26.26ANISOU 314 C LEU 39 28683969 3143 -796 170 335ATOM315 O LEU 39 13.105 31.86153.2661.000 35.57ANISOU 315 O LEU 39 49904057 4470 804-630 320ATOM316 N THR 40 11.388 33.13653.8271.000 26.61ANISOU 316 N THR 40 34253883 2803 -703 -191 102ATOM317 CA THR 40 11.676 33.32955.2281.000 22.95ANISOU 317 CA THR 40 19723864 2886 4 -608 518ATOM318 C THR 40 10.380 33.42456.0311.000 27.03ANISOU 318 C THR 40 23314900 3040 -690 -220 -3ATOM319 O THR 40 9.254 33.31655.5371.000 25.98ANISOU 319 O THR 40 21484860 2864 -546 36-720ATOM320 CB THR 40 12.476 34.62455.4561.000 27.16ANISOU 320 CB THR 40 26464799 2874 -932 -391 148ATOM321 OG1THR 40 11.639 35.68754.9861.000 36.24ANISOU 321 OG1THR 40 51583872 4740 -472 -136 660ATOM322 CG2THR 40 13.771 34.66954.6591.000 34.29ANISOU 322 CG2THR 40 52683289 4470 -1303 2206 429ATOM323 N ASP 41 10.524 33.63557.3461.000 28.20ANISOU 323 N ASP 41 22705223 3223 -711 -317 -479ATOM324 CA ASP 41 9.324 33.60458.1911.000 25.10ANISOU 324 CA ASP 41 19354633 2968 13 -551 -505ATOM325 C ASP 41 8.418 34.78557.8961.000 24.69ANISOU 325 C ASP 41 26863839 2855 -446 -749 -241ATOM326 O ASP 41 7.219 34.84658.1631.000 24.79ANISOU 326 O ASP 41 27572721 3941 174-584 -141ATOM327 CB ASP 41 9.728 33.54959.6781.000 28.21ANISOU 327 CB ASP 41 22215503 2995 892-594 -555ATOM328 CG ASP 41 9.892 32.12960.1801.000 42.46ANISOU 328 CG ASP 41 64375911 3784 -1196 -1257 826ATOM329 OD1ASP 41 9.705 31.16159.4011.000 55.96ANISOU 329 OD1ASP 41 12184 5138 3940 -2654 -82 1249ATOM330 OD2ASP 41 10.214 31.95161.3831.000 61.55ANISOU 330 OD2ASP 41 10370 7470 5548 -4396 -4720 2309ATOM331 N THR 42 8.991 35.80757.3051.000 29.30ANISOU 331 N THR 42 37614531 2839 -1404 -1089 -72ATOM332 CA THR 42 8.255 36.97656.8631.000 33.69ANISOU 332 CA THR 42 48523472 4475 -1524 -819 -127ATOM333 C THR 42 7.199 36.59855.8341.000 29.14ANISOU 333 C THR 42 33543051 4667 204-648 -277ATOM334 O THR 42 6.026 36.96955.8441.000 36.90ANISOU 334 O THR 42 35782980 7462 603-176 643ATOM335 CB THR 42 9.282 37.96756.2811.000 40.80ANISOU 335 CB THR 42 58314318 5354 -2254 -450 37ATOM336 OG1THR 42 10.288 38.31757.2631.000 46.30ANISOU 336 OG1THR 42 6998 3682 6912 -3163 -1478 177ATOM337 CG2THR 42 8.582 39.25355.8721.000 45.59ANISOU 337 CG2THR 42 9083 3877 4363 -2166 -1048 238ATOM338 N GLU 43 7.573 35.77354.8621.000 31.74ANISOU 338 N GLU 43 3380 4360 4319 -673 -223 -782ATOM339 CA GLU 43 6.647 35.35553.8101.000 35.40ANISOU 339 CA GLU 43 4856 4683 3913 -1510 -860 329ATOM340 C GLU 43 5.643 34.32454.3301.000 28.03ANISOU 340 C GLU 43 2988 3297 4363 -41-919 168ATOM341 O GLU 43 4.560 34.13853.7641.000 38.18ANISOU 341 O GLU 43 3818 2970 7717 -66-2774 1469ATOM342 CB GLU 43 7.423 34.81152.6081.000 38.89ANISOU 342 CB GLU 43 4464 6532 3779 -2546 -860 -393ATOM343 CG GLU 43 8.462 35.74552.0101.000 46.47ANISOU 343 CG GLU 43 5175 7105 5377 -2936 -92 -289ATOM344 CD GLU 43 9.750 35.76452.8261.000 46.40ANISOU 344 CD GLU 43 4506 7977 5145 -3155 548 -1210ATOM345 OE1GLU 43 9.775 36.44753.8801.000 55.20ANISOU 345 OE1GLU 43 8741 7607 4627 -2062 -1002 -669ATOM346 OE2GLU 43 10.706 35.08052.4331.000 56.77ANISOU 346 OE2GLU 43 4592 8930 8050 -2652 939 -1258ATOM347 N LEU 44 5.980 33.64555.4261.000 22.72ANISOU 347 N LEU 44 2508 2161 3964 464-476 -450ATOM348 CA LEU 44 5.117 32.59255.9591.000 26.76ANISOU 348 CA LEU 44 4009 1973 4187 140570 -986ATOM349 CB LEU 44 5.978 31.58556.7271.000 28.25ANISOU 349 CB LEU 44 5094 2194 3448 -153 277 -562ATOM350 CG LEU 44 5.284 30.49457.5331.000 32.03ANISOU 350 CG LEU 44 5971 2801 3398 -279 1192 -627ATOM351 CD1LEU 44 4.485 29.53556.6561.000 37.95ANISOU 351 CD1LEU 44 7665 2239 4514 -1148 2039 -1403ATOM352 CD2LEU 44 6.302 29.70358.3611.000 36.97ANISOU 352 CD2LEU 44 7096 2869 4080 1150 2171 186ATOM353 C LEU 44 4.000 33.14556.8411.000 31.10ANISOU 353 C LEU 44 3835 3182 4800 -700 837 -2205ATOM354 O LEU 44 2.913 32.54356.8671.000 30.19ANISOU 354 O LEU 44 4402 3299 3768 -1248 870 -2165ATOM355 N ALA 45 4.238 34.24757.5471.000 28.74ANISOU 355 N ALA 45 2897 2938 5083 -562 710 -2061ATOM356 CA ALA 45 3.382 34.75158.6231.000 27.09ANISOU 356 CA ALA 45 2716 2817 4761 -751 467 -2140ATOM357 C ALA 45 1.943 35.01458.1951.000 24.95ANISOU 357 C ALA 45 2697 3110 3673 -784 709 -1257ATOM358 O ALA 45 1.021 34.51558.8751.000 22.50ANISOU 358 O ALA 45 2762 2585 3201 -565 560 -1146ATOM359 CB ALA 45 3.975 36.00559.2481.000 36.30ANISOU 359 CB ALA 45 3259 4219 6315 -1912 1332 -3404ATOM360 N SER 46 1.729 35.77957.1281.000 26.85ANISOU 360 N SER 46 3258 3756 3187 -1732 618 -1184ATOM361 CA SER 46 0.380 36.05256.6421.000 24.97ANISOU 361 CA SER 46 3686 3189 2611 -1223 511 -1105ATOM362 CB SER 46 0.422 36.95055.3921.000 32.35ANISOU 362 CB SER 46 5428 3467 3395 -2232 70-458ATOM363 OG SER 46 0.630 38.28955.7721.000 45.77ANISOU 363 OG SER 46 7730 3349 6313 -2746 2499 -807ATOM364 C SER 46 -0.408 34.78756.3071.000 20.63ANISOU 364 C SER 46 2797 2469 2572 -423 -151 -542ATOM365 O SER 46 -1.578 34.67256.6981.000 21.93ANISOU 365 O SER 46 3120 2486 2725 -559 305 -403ATOM366 N ALA 47 0.211 33.85555.5901.000 22.39ANISOU 366 N ALA 47 3096 2167 3244 -488 394 -368ATOM367 CA ALA47 -0.397 32.59655.1761.000 19.54ANISOU 367 CA ALA47 27461863 2814 -289 362 -18ATOM368 CB ALA47 0.548 31.90054.1911.000 23.54ANISOU 368 CB ALA47 35241717 3705 -617 1237 -159ATOM369 CALA47 -0.715 31.71456.3811.000 19.95ANISOU 369 CALA47 22822546 2752 -327 19257ATOM370 OALA47 -1.836 31.19956.5181.000 19.66ANISOU 370 OALA47 24892589 2393 -614 211 -165ATOM371 NLYS48 0.270 31.55857.2681.000 18.24ANISOU 371 NLYS48 27131966 2253 -210 -139 -912ATOM372 CA LYS48 0.042 30.78258.4861.000 19.33ANISOU 372 CA LYS48 23982625 2321 43 -312 -563ATOM373 CLYS48 -1.110 31.32959.3221.000 20.57ANISOU 373 CLYS48 24762556 2785 -326 83-566ATOM374 OLYS48 -2.022 30.61359.7711.000 20.34ANISOU 374 OLYS48 32072598 1923 -521 139 -340ATOM375 CB LYS48 1.352 30.75859.2941.000 24.61ANISOU 375 CB LYS48 24003792 3158 -258 -556 -80ATOM376 CG LYS48 1.237 29.87360.5311.000 30.84ANISOU 376 CG LYS48 43064044 3366 -291 -1504 277ATOM377 CD LYS48 1.837 30.57561.7361.000 41.45ANISOU 377 CD LYS48 67425755 3251 -1067 -1382 -356ATOM378 CE LYS48 1.625 29.71762.9661.000 41.63ANISOU 378 CE LYS48 66206124 3073 -466 -1047 -353ATOM379 NZ LYS48 1.074 30.49764.1121.000 42.62ANISOU 379 NZ LYS48 58836866 3444 460-1193 -425ATOM380 NASP49 -1.110 32.62559.6071.000 19.18ANISOU 380 NASP49 23482602 2337 -464 100 -806ATOM381 CA ASP49 -2.127 33.24360.4331.000 21.95ANISOU 381 CA ASP49 25552986 2801 -791 617 -1035ATOM382 CB ASP49 -1.868 34.75660.6111.000 23.97ANISOU 382 CB ASP49 28272872 3409 -250 -79 -1325ATOM383 CG ASP49 -0.681 35.07861.4921.000 25.41ANISOU 383 CG ASP49 27873405 3464 -365 113 -1866ATOM384 OD1 ASP49 -0.153 34.15362.1431.000 30.75ANISOU 384 OD1 ASP49 35724181 3932 -254 -967 -1667ATOM385 OD2 ASP49 -0.235 36.25661.5631.000 30.78ANISOU 385 OD2 ASP49 33033649 4742 -710 344 -2413ATOM386 CASP49 -3.543 33.06159.9041.000 21.44ANISOU 386 CASP49 24652651 3030 -388 540 -900ATOM387 OASP49 -4.476 32.77060.6541.000 20.72ANISOU 387 OASP49 23462181 3347 -279 550 -726ATOM388 NLEU50 -3.731 33.26958.5961.000 23.28ANISOU 388 NLEU50 29422712 3191 -1251 216 -644ATOM389 CA LEU50 -5.086 33.18558.0681.000 22.94ANISOU 389 CA LEU50 31041796 3815 -575 -205 -1079ATOM390 CB LEU50 -5.204 33.86156.6961.000 28.78ANISOU 390 CB LEU50 39482453 4535 -852 -755 -254ATOM391 CG LEU50 -6.620 34.24656.2601.000 25.30ANISOU 391 CG LEU50 38002294 3520 30 325 -531ATOM392 CD1 LEU50 -7.552 34.47857.4411.000 44.77ANISOU 392 CD1 LEU50 63824432 6196 -475 3026 -1060ATOM393 CD2 LEU50 -6.625 35.48555.3851.000 32.52ANISOU 393 CD2 LEU50 58611962 4533 752354 -433ATOM394 CLEU50 -5.566 31.73757.9821.000 21.12ANISOU 394 CLEU50 25591870 3595 -643 742 -1270ATOM395 OLEU50 -6.772 31.49458.1751.000 21.13ANISOU 395 OLEU50 2491 2457 3083 -543 579 -1097ATOM396 NVAL51 -4.681 30.76957.7151.000 16.27ANISOU 396 NVAL51 25171843 1823 -302 -3-646ATOM397 CA VAL51 -5.186 29.37057.7011.000 18.07ANISOU 397 CA VAL 51 3154 1763 1947 -401 -15 -427ATOM398 CB VAL 51 -4.281 28.41556.889 1.000 16.07ANISOU 398 CB VAL 51 2981 1629 1496 -621 -255 -501ATOM399 CG1 VAL 51 -3.002 28.11457.668 1.000 18.99ANISOU 399 CG1 VAL 51 2959 2382 1875 -383 -100 302ATOM400 CG2 VAL 51 -5.006 27.11956.497 1.000 22.16ANISOU 400 CG2 VAL 51 4569 2121 1728 -1393 64-869ATOM401 CVAL 51 -5.446 28.89959.114 1.000 17.74ANISOU 401 CVAL 51 2508 2223 2009 -435 142 -445ATOM402 OVAL 51 -6.430 28.18759.346 1.000 19.76ANISOU 402 OVAL 51 3005 2160 2345 -692 726 -1021ATOM403 NILE 52 -4.671 29.26360.125 1.000 20.23ANISOU 403 NILE 52 2980 2945 1760 -649 364 -902ATOM404 CA ILE 52 -4.990 28.87561.507 1.000 20.17ANISOU 404 CA ILE 52 3200 2665 1800 -758 627 -1134ATOM405 CB ILE 52 -3.847 29.23062.469 1.000 21.31ANISOU 405 CB ILE 52 3294 3151 1652 -449 462 -1043ATOM406 CG2 ILE 52 -4.238 29.17863.931 1.000 21.29ANISOU 406 CG2 ILE 52 3543 2826 1719 -362 529 -689ATOM407 CG1 ILE 52 -2.619 28.34662.217 1.000 25.37ANISOU 407 CG1 ILE 52 3213 3819 2608 -307 727 -1090ATOM408 CD1 ILE 52 -2.871 26.87262.470 1.000 28.56ANISOU 408 CD1 ILE 52 3474 3578 3798 106178 -1110ATOM409 CILE 52 -6.284 29.51461.950 1.000 22.44ANISOU 409 CILE 52 3119 3216 2190 -710 645 -1228ATOM410 OILE 52 -7.072 28.85662.647 1.000 23.23ANISOU 410 OILE 52 3390 3654 1781 -766 758 -1246ATOM411 NASP 53 -6.519 30.75461.530 1.000 23.33ANISOU 411 NASP 53 2897 3064 2903 -626 700 -1361ATOM412 CA ASP 53 -7.826 31.33561.897 1.000 24.49ANISOU 412 CA ASP 53 2818 3347 3141 -759 781 -1545ATOM413 CB ASP 53 -7.942 32.78161.411 1.000 27.43ANISOU 413 CB ASP 53 2854 3335 4235 -434 819 -1446ATOM414 CG ASP 53 -9.309 33.39761.570 1.000 30.99ANISOU 414 CG ASP 53 3166 4281 4326 36 1242 -1214ATOM415 OD1 ASP 53 -9.657 33.77962.705 1.000 37.26ANISOU 415 OD1 ASP 53 4369 4569 5220 1531263 -2733ATOM416 OD2 ASP 53 -10.050 33.49160.553 1.000 38.45ANISOU 416 OD2 ASP 53 3393 6043 5173 810557 -1648ATOM417 CASP 53 -8.953 30.49561.316 1.000 24.64ANISOU 417 CASP 53 3028 3701 2634 -919 372 -1031ATOM418 OASP 53 -10.011 30.32761.915 1.000 28.52ANISOU 418 OASP 53 3399 3835 3603 -1519 962 -2151ATOM419 NPHE 54 -8.744 29.97860.108 1.000 22.04ANISOU 419 NPHE 54 2921 2974 2479 -573 174 -704ATOM420 CA PHE 54 -9.772 29.18759.432 1.000 19.99ANISOU 420 CA PHE 54 2253 2879 2463 -421 771 -978ATOM421 CB PHE 54 -9.423 29.03057.942 1.000 18.45ANISOU 421 CB PHE 54 2856 1983 2171 -65426 -518ATOM422 CG PHE 54 -10.493 28.29257.145 1.000 21.36ANISOU 422 CG PHE 54 3063 2735 2318 -646 599 -627ATOM423 CD1 PHE 54 -11.714 28.90656.933 1.000 23.18ANISOU 423 CD1 PHE 54 3199 2783 2826 -703 -29 -624ATOM424 CD2 PHE 54 -10.293 27.03556.619 1.000 23.32ANISOU 424 CD2 PHE 54 3482 2802 2577 -689 212 -858ATOM425 CE1 PHE 54 -12.719 28.29156.241 1.000 26.45ANISOU 425 CE1 PHE 54 3345 3696 3008 -1418 129 -554ATOM426 CE2 PHE 54 -11.303 26.37555.921 1.000 25.65ANISOU 426 CE2 PHE 54 3750 3815 2182 -1404 607 -1005ATOM427 CZ PHE 54 -12.522 27.01355.725 1.000 26.17ANISOU 427 CZ PHE 54 3433 3830 2679 -1829 298 -813ATOM428 CPHE 54 -9.959 27.85460.1321.000 19.44ANISOU 428 CPHE 54 23403430 1617 -834 319 -759ATOM429 OPHE 54 -11.08727.45060.3861.000 22.11ANISOU 429 OPHE 54 26013066 2734 -948 1018 -1466ATOM430 NPHE 55 -8.882 27.16660.4481.000 20．59ANISOU 430 NPHE 55 27283375 1720 -666 180 -611ATOM431 CA PHE 55 -8.966 25.92761.2121.000 22.59ANISOU 431 CA PHE 55 30923671 1820 -728 381 -372ATOM432 CB PHE 55 -7.579 25.36061.4781.000 21.93ANISOU 432 CB PHE 55 31633622 1549 -692 287 -158ATOM433 CG PHE 55 -6.790 24.83360.2841.000 20.60ANISOU 433 CG PHE 55 30342998 1793 -1004 365 -375ATOM434 CD1 PHE 55 -7.352 24.52659.0571.000 18.72ANISOU 434 CD1 PHE 55 23003095 1717 -1078 586 -271ATOM435 CD2 PHE 55 -5.430 24.61560.3851.000 18.06ANISOU 435 CD2 PHE 55 31322490 1241 -926 128 -497ATOM436 CE1 PHE 55 -6.609 24.03758.0141.000 18.92ANISOU 436 CE1 PHE 55 24552761 1971 -844 436 -542ATOM437 CE2 PHE 55 -4.672 24.12459.3521.000 18.58ANISOU 437 CE2 PHE 55 32912606 1163 -478 63-299ATOM438 CZ PHE 55 -5.256 23.81458.1341.000 17.68ANISOU 438 CZ PHE 55 26602567 1490 -380 129 -806ATOM439 CPHE 55 -9.684 26.11162.5461.000 24.99ANISOU 439 CPHE 55 33104138 2046 -830 647 -415ATOM440 OPHE 55 -10.53225.28162.8721.000 30.29ANISOU 440 OPHE 55 38024943 2763 -1527 1314 -1102ATOM441 NGLU 56 -9.330 27.14463.3111.000 23.65ANISOU 441 NGLU 56 28644109 2013 -634 937 -525ATOM442 CA GLU 56 -9.868 27.35564.6361.000 30.01ANISOU 442 CA GLU 56 36325378 2394 -1050 1465 -994ATOM443 CB GLU 56 -8.998 28.33365.4361.000 36.40ANISOU 443 CB GLU 56 45316933 2367 -1606 1318 -1623ATOM444 CG GLU 56 -7.666 27.82765.9161.000 41.89ANISOU 444 CO GLU 56 50068196 2713 -1457 404 -1900ATOM445 CD GLU 56 -6.787 28.88066.5751.000 48.94ANISOU 445 CD GLU 56 60819310 3202 -2278 -73 -2062ATOM446 OE1 GLU 56 -5.694 28.51567.0781.000 60.73ANISOU 446 OE1 GLU 56 803412274 2769 -3208 -2335 266ATOM447 OE2 GLU 56 -7.145 30.08466.6141.000 58.51ANISOU 447 OE2 GLU 56 87429338 4151 -2088 1096 -3951ATOM448 CGLU 56 -11.28927.92064.6171.000 30.60ANISOU 448 CGLU 56 37644923 2941 -977 1967 -1271ATOM449 OGLU 56 -12.05827.54265.5041.000 35.21ANISOU 449 OGLU 56 43845304 3690 -1136 2652 -1235ATOM450 NHIS 57 -11.60328.80563.6731.000 30.00ANISOU 450 NHIS 57 37304846 2823 -654 1684 -1582ATOM451 CA HIS 57 -12.85429.55963.7591.000 33.51ANISOU 451 CA HIS 57 38535101 3778 -519 1673 -1911ATOM452 CB HIS 57 -12.53631.04663.9911.000 33.40ANISOU 452 CB HIS 57 38445183 3664 -411 1546 -2250ATOM453 CG HIS 57 -11.57731.34465.0951.000 35.13ANISOU 453 CG HIS 57 44975409 3444 -505 1340 -1992ATOM454 CD2 HIS 57 -10.36131.94665.0711.000 35.26ANISOU 454 CD2 HIS 57 48375214 3345 -834 637 -1456ATOM455 ND1 HIS 57 -11.81931.02166.4111.000 40.52ANISOU 455 ND1 HIS 57 60215885 3490 -1360 1474 -2002ATOM456 CE1 HIS 57 -10.79831.41067.1511.000 42.28ANISOU 456 CE1 HIS 57 66806066 3320 -1632 1099 -1772ATOM457 NE2 HIS 57 -9.902 31.97066.3621.000 41.69ANISOU 457 NE2 HIS 57 63776133 3329 -1817 407 -1148ATOM458 CHIS 57 -13.76929.46662.5471.000 32.58ANISOU 458 C HIS 57 3083 5097 4199 -729 1723 -2066ATOM459 O HIS 57 -14.902 29.96562.5781.000 33.80ANISOU 459 O HIS 57 3121 5097 4625 -731 1865 -2565ATOM460 N GLY 58 -13.370 28.86661.4321.000 28.78ANISOU 460 N GLY 58 2841 4353 3742 -253 1341 -1506ATOM461 CA GLY 58 -14.326 28.68560.3321.000 26.99ANISOU 461 CA GLY 58 2471 3916 3869 24 1298 -1173ATOM462 C GLY 58 -15.447 27.73760.7381.000 29.94ANISOU 462 C GLY 58 2665 4357 4353 -261 1323 -1058ATOM463 O GLY 58 -15.241 26.80561.5341.000 29.23ANISOU 463 O GLY 58 2976 4044 4087 -571 1192 -1297ATOM464 N SER 59 -16.635 27.95860.1931.000 27.61ANISOU 464 N SER 59 2556 3905 4029 -108 1461 -1767ATOM465 CA SER 59 -17.812 27.15360.4971.000 28.42ANISOU 465 CA SER 59 2675 4074 4049 -189 1294 -1325ATOM466 CB SER 59 -19.12 127.889 60.1621.000 28.29ANISOU 466 CB SER 59 2556 4574 3618 -339 1198 -928ATOM467 OG SER 59 -19.229 27.97858.7391.000 28.66ANISOU 467 OG SER 59 3598 3742 3547 1661729 -867ATOM468 C SER 59 -17.795 25.84359.7241.000 29.57ANISOU 468 C SER 59 3467 3990 3779 -646 1463 -1206ATOM469 O SER 59 -16.990 25.65158.8101.000 22.72ANISOU 469 O SER 59 3054 3042 2537 -144 648 -369ATOM470 N GLU 60 -18.698 24.93960.1031.000 26.90ANISOU 470 N GLU 60 2413 3900 3907 -691079 -853ATOM471 CA GLU 60 -18.699 23.68459.3591.000 26.98ANISOU 471 CA GLU 60 2699 3515 4037 -98709 -537ATOM472 CB GLU 60 -19.646 22.68160.0011.000 39.11ANISOU 472 CB GLU 60 5393 4393 5075 -1361 908 364ATOM473 CG GLU 60 -19.011 21.66560.9171.000 44.63ANISOU 473 CG GLU 60 5606 5473 5878 -977 1079 1219ATOM474 CD GLU 60 -17.507 21.54360.7971.000 48.52ANISOU 474 CD GLU 60 5714 6217 6503 -390 1207 877ATOM475 OE1GLU 60 -17.030 21.22359.6841.000 48.11ANISOU 475 OE1GLU 60 5349 7545 5384 709366 1951ATOM476 OE2GLU 60 -16.828 21.76361.8291.000 46.50ANIS0U 476 OE2GLU 60 4926 5742 7000 1158 1550 -1504ATOM477 C GLU 60 -19.091 23.96057.9151.000 25.30ANISOU 477 C GLU 60 2829 2728 4055 86 725 -656ATOM478 O GLU 60 -18.529 23.34657.0271.000 24.18ANISOU 478 O GLU 60 2119 2980 4091 -202 741 -752ATOM479 N ALA 61 -20.032 24.89057.7161.000 25.58ANISOU 479 N ALA 61 2083 3206 4432 -34612 -774ATOM480 CA ALA 61 -20.495 25.21256.3681.000 24.05ANISOU 480 CA ALA 61 1838 2999 4301 228720 -1055ATOM481 CB ALA 61 -21.670 26.17656.4591.000 27.53ANISOU 481 CB ALA 61 2807 1857 5797 394704 -606ATOM482 C ALA 61 -19.385 25.79055.5001.000 27.31ANISOU 482 C ALA 61 3170 2572 4633 -377 1178 -1026ATOM483 O ALA 61 -19.247 25.46754.3111.000 22.29ANISOU 483 O ALA 61 2363 1876 4232 42 661 -319ATOM484 N GLU 62 -18.580 26.64256.1181.000 22.18ANISOU 484 N GLU 62 2075 2258 4094 396569 -394ATOM485 CA GLU 62 -17.455 27.25855.4161.000 24.19ANISOU 485 CA GLU 62 2401 2603 4188 150852 -590ATOM486 CB GLU 62 -16.806 28.35456.2771.000 24.68ANISOU 486 CB GLU 62 2401 2490 4485 91 1273 -828ATOM487 CG GLU 62 -17.641 29.63656.3561.000 25.19ANISOU 487 CG GLU 62 2542 2620 4409 353421 -685ATOM488 CD GLU 62 -17.288 30.58157.4801.000 29.27ANISOU 488 CD GLU 62 3284 2991 4845 621515 -1290ATOM 489 OE1 GLU 62 -16.527 30.241 58.410 1.000 30.11ANISOU 489 OE1 GLU 62 3231 3067514331856-1639ATOM 490 OE2 GLU 62 -17.796 31.739 57.436 1.000 35.30ANISOU 490 OE2 GLU 62 4832 29945584863109 -1327ATOM 491 C GLU 62 -16.409 26.226 55.025 1.000 21.70ANISOU 491 C GLU 62 2394 2421343030 784 -579ATOM 492 O GLU 62 -15.818 26.218 53.940 1.000 9.44ANISOU 492 O GLU 62 2095 21403153-301 467 -604ATOM 493 N LYS 63 -16.184 25.308 55.972 1.000 20.08ANISOU 493 N LYS 63 2472 22662893-74761 -902ATOM 494 CA LYS 63 -15.246 24.227 55.678 1.000 19.73ANISOU 494 CA LYS 63 2322 25592614133429 -903ATOM 495 CB LYS 63 -14.934 23.497 56.988 1.000 18.48ANISOU 495 CB LYS 63 1803 27432476-218 587 -836ATOM 496 CG LYS 63 -13.946 24.240 57.881 1.000 19.17ANISOU 496 CG LYS 63 2115 23322836-296 325 -674ATOM 497 CD LYS 63 -13.839 23.651 59.290 1.000 26.23ANISOU 497 CD LYS 63 2978 40842902-888 -177 -287ATOM 498 CE LYS 63 -12.753 24.383 60.068 1.000 27.75ANISOU 498 CE LYS 63 3074 50082461-1239 500 -1082ATOM 499 NZ LYS 63 -12.929 24.378 61.530 1.000 34.95ANISOU 499 NZ LYS 63 3177 75792524-2594 840 -894ATOM 500 C LYS 63 -15.789 23.304 54.586 1.000 17.52ANISOU 500 C LYS 63 2014 2191245351 529 -691ATOM 501 O LYS 63 -15.025 22.953 53.654 1.000 17.58ANISOU 501 O LYS 63 2266 17092704158707 -653ATOM 502 N ARG 64 -17.069 22.912 54.641 1.000 19.63ANISOU 502 N ARG 64 2081 24522926-14614 -592ATOM 503 CA ARG 64 -17.618 22.041 53.595 1.000 19.00ANISOU 503 CA ARG 64 1509 25263185-3 620 -652ATOM 504 C ARG 64 -17.471 22.634 52.194 1.000 20.42ANISOU 504 C ARG 64 2165 24363157-390 -22 -536ATOM 505 O ARG 64 -17.204 21.934 51.195 1.000 18.83ANISOU 505 O ARG 64 1854 21843115-434 575 -201ATOM 506 CB ARG 64 -19.080 21.670 53.871 1.000 24.70ANISOU 506 CB ARG 64 1470 36524263-51841 -909ATOM 507 CG ARG 64 -19.838 20.933 52.795 1.000 36.49ANISOU 507 CG ARG 64 2961 52845621-2020 138 -882ATOM 508 CD ARG 64 -21.315 20.645 53.095 1.000 46.32ANISOU 508 CD ARG 64 3034 69627603-2438 327 -1187ATOM 509 NE ARG 64 -21.776 21.216 54.331 1.000 55.81ANISOU 509 NE ARG 64 3917 86368652-3960 2222 -1870ATOM 510 CZ ARG 64 -22.814 21.840 54.811 1.000 58.82ANISOU 510 CZ ARG 64 4438 89398972-3479 1988 -2480ATOM 511 NH1 ARG 64 -23.884 22.106 54.071 1.000 76.83ANISOU 511 NH1 ARG 64 6024 952713641 -1787 -165 -1872ATOM 512 NH2 ARG 64 -22.797 22.213 56.093 1.000 69.53ANISOU 512 NH2 ARG 64 7792 92019424-5884 3891 -3304ATOM 513 N ALA 65 -17.621 23.947 52.066 1.000 20.43ANISOU 513 N ALA 65 1689 2554351924 612 -525ATOM 514 CA ALA 65 -17.505 24.656 50.782 1.000 19.45ANISOU 514 CA ALA 65 1649 22163523409184 -553ATOM 515 CB ALA 65 -17.912 26.108 50.984 1.000 23.73ANISOU 515 CB ALA 65 1420 20195579126-373 -742ATOM 516 C ALA 65 -16.118 24.549 50.168 1.000 17.89ANISOU 516 C ALA 65 1524 20993173-47108 -101ATOM 517 O ALA 65 -15.983 24.732 48.954 1.000 18.77ANISOU 517 O ALA 65 1830 21783123122-8-229ATOM 518 N VAL 66 -15.100 24.248 50.973 1.000 17.99ANISOU 518 N VAL 66 1547 21513137-8636-196ATOM 519 CA VAL 66 -13.746 24.066 50.430 1.000 16.74ANISOU 519 CA VAL 66 1553 1859 2948 -62-56 -254ATOM520 CB VAL 66 -12.775 25.15150.9511.000 17.29ANISOU 520 CB VAL 66 1805 1804 2963 -330 338 -185ATOM521 CG1 VAL 66 -13.238 26.53250.4551.000 16.70ANISOU 521 CG1 VAL 66 1547 1800 2997 111545 -553ATOM522 CG2 VAL 66 -12.652 25.18052.4621.000 18.65ANISOU 522 CG2 VAL 66 2053 1996 3036 -193 17-538ATOM523 CVAL 66 -13.201 22.68050.7241.000 15.66ANISOU 523 CVAL 66 1775 1813 2362 -70-250 -457ATOM524 OVAL 66 -11.972 22.49350.8081.000 14.19ANISOU 524 OVAL 66 1747 1576 2069 -122 -56 -347ATOM525 NTHR 67 -14.071 21.69550.8731.000 14.46ANISOU 525 NTHR 67 1550 1602 2343 126-48 -722ATOM526 CA THR 67 -13.723 20.27951.0001.000 14.06ANISOU 526 CA THR 67 1461 1698 2185 2345 -740ATOM527 CB THR 67 -14.419 19.64752.2251.000 15.08ANISOU 527 CB THR 67 1721 1955 2053 -51-426 -444ATOM528 OG1 THR 67 -14.089 20.33753.4531.000 17.41ANISOU 528 OG1 THR 67 2538 1949 2128 -3970-716ATOM529 CG2 THR 67 -13.915 18.21552.4201.000 16.63ANISOU 529 CG2 THR 67 2182 1888 2248 148293 -658ATOM530 CTHR 67 -14.067 19.51849.7281.000 12.37ANISOU 530 CTHR 67 1144 1422 2132 209-95 -517ATOM531 OTHR 67 -15.208 19.56749.2291.000 14.82ANISOU 531 OTHR 67 1197 2086 2350 208-168 -362ATOM532 NSER 68 -13.092 18.79049.1801.000 11.61ANISOU 532 NSER 68 1109 1421 1881 37 -58 -534ATOM533 CA SER 68 -13.306 17.95548.0031.000 11.45ANISOU 533 CA SER 68 1274 1444 1631 -49-30 -374ATOM534 CB SER 68 -12.027 17.31747.4801.000 11.88ANISOU 534 CB SER 68 1446 1523 1544 79 252 -157ATOM535 OG SER 68 -11.026 18.29247.2391.000 16.95ANISOU 535 OG SER 68 1557 2314 2569 -336 389 -218ATOM536 CSER 68 -14.269 16.81548.3191.000 11.56ANISOU 536 CSER 68 1287 1375 1732 -6153-406ATOM537 OSER 68 -14.308 16.38449.4761.000 14.62ANISOU 537 OSER 68 1998 1860 1697 -538 153 -430ATOM538 NPRO 69 -15.026 16.32447.3441.000 12.78ANISOU 538 NPRO 69 1476 1473 1905 -243 -88 -194ATOM539 CD PRO 69 -15.130 16.80145.9531.000 12.47ANISOU 539 CD PRO 69 1022 1808 1909 -199 -203 -144ATOM540 CA PRO 69 -15.941 15.21447.6391.000 12.21ANISOU 540 CA PRO 69 1358 1369 1913 -178 148 -437ATOM541 CB PRO 69 -16.825 15.19346.3551.000 13.94ANISOU 541 CB PRO 69 1362 1591 2343 -251 -178 -14ATOM542 CG PRO 69 -15.924 15.71545.2901.000 14.38ANISOU 542 CG PRO 69 1396 1947 2122 -554 -511 178ATOM543 CPRO 69 -15.270 13.88247.9121.000 13.25ANISOU 543 CPRO 69 1206 1526 2303 -217 -115 -100ATOM544 OPRO 69 -15.932 12.98548.4811.000 14.01ANISOU 544 OPRO 69 1753 1450 2122 -373 99-301ATOM545 NVAL 70 -14.015 13.69247.5541.000 13.46ANISOU 545 NVAL 70 1288 1479 2348 -174 -108 -265ATOM546 CA VAL 70 -13.184 12.54847.8981.000 13.49ANISOU 546 CA VAL 70 1404 1692 2030 37 138 -195ATOM547 CB VAL 70 -12.587 11.72046.7371.000 16.39ANISOU 547 CB VAL 70 2142 1648 2439 -225 614 -452ATOM548 CG1 VAL 70 -13.615 10.75646.2081.000 33.50ANISOU 548 CG1 VAL 70 6470 2984 3274 -2702 41-867ATOM549 CG2 VAL 70 -11.995 12.61345.6401.000 16.46ANISOU 549 CG2 VAL 70 1749 2234 2273 269444 23ATOM550 C VAL 70 12.042 13.05748.7821.000 13.59ANISOU 550 C VAL 70 1618 1382 2163 -38-114 127ATOM551 O VAL 70 -11.426 14.10548.4931.000 14.20ANISOU 551 O VAL 70 1748 1685 1964 -265 26182ATOM552 N PRO 71 -11.786 12.36549.8981.000 14.21ANISOU 552 N PRO 71 1607 1507 2285 -115 -62 310ATOM553 CD PRO 71 -12.432 11.12550.3781.000 14.70ANISOU 553 CD PRO 71 1920 1590 2076 -201 646 4ATOM554 CA PRO 71 -10.830 12.91950.8781.000 17.41ANISOU 554 CA PRO 71 2429 2008 2178 -522 -342 418ATOM555 CB PRO 71 -11.338 12.30452.1931.000 20.87ANIS0U 555 CB PRO 71 3768 2082 2081 -743 190 14ATOM556 CG PRO 71 -11.908 10.98951.7751.000 18.28ANISOU 556 CG PRO 71 3534 1665 1746 -338 781 -54ATOM557 C PRO 71 -9.384 12.54350.6191.000 17.14ANISOU 557 C PRO 71 2183 2304 2026 -684 -815 44ATOM558 O PRO 71 -8.730 11.79651.3301.000 20.54ANISOU 558 O PRO 71 2745 2610 2448 -87-404 414ATOM559 N THR 72 -8.834 13.11149.5561.000 16.59ANISOU 559 N THR 72 2156 2046 2103 -235 -508 -17ATOM560 CA THR 72 -7.496 12.81849.0901.000 17.43ANISOU 560 CA THR 72 2113 1884 2626 -254 -510 -288ATOM561 CB THR 72 -7.477 12.82947.5451.000 15.98ANISOU 561 CB THR 72 1700 1761 2611 211-458 -421ATOM562 OG1THR 72 -8.027 14.09447.1281.000 17.28ANISOU 562 OG1THR 72 2146 1553 2868 27 -355 -271ATOM563 CG2THR 72 -8.348 11.76446.9291.000 12.63ANISOU 563 CG2THR 72 1296 1581 1923 -46328 -127ATOM564 C THR 72 -6.418 13.80549.5491.000 17.83ANISOU 564 C THR 72 2153 1773 2847 -155 -1228 232ATOM565 O THR 72 -5.216 13.53649.3291.000 20.17ANISOU 565 O THR 72 2142 2265 3257 -225 -1049 480ATOM566 N MET 73 -6.785 14.92050.1691.000 19.43ANISOU 566 N MET 73 2876 2052 2455 -782 -451 -144ATOM567 CA MET 73 -5.799 15.94450.5211.000 18.75ANISOU 567 CA MET 73 2117 2326 2682 -538 -466 -280ATOM568 CB MET 73 -4.758 15.33851.4801.000 22.03ANISOU 568 CB MET 73 1826 2825 3718 -377 -306 595ATOM569 CG MET 73 -5.374 15.05952.8431.000 27.01ANISOU 569 CG MET 73 3545 2853 3864 -84-87 1526ATOM570 SD MET 73 -4.107 14.85054.1071.000 32.23ANISOU 570 SD MET 73 4364 4245 3637 469-400 583ATOM571 CE MET 73 -3.179 13.49253.3741.000 26.74ANISOU 571 CE MET 73 2885 4895 2381 326425 1348ATOM572 C MET 73 -5.066 16.58249.3551.000 17.20ANISOU 572 C MET 73 1338 2129 3067 -20-269 -175ATOM573 O MET 73 -3.945 17.11049.4981.000 21.20ANISOU 573 O MET 73 1713 2512 3832 -541 51-1024ATOM574 N ARG 74 -5.630 16.60048.1751.000 18.64ANISOU 574 N ARG 74 1881 2051 3150 84 -461 543ATOM575 CA ARG 74 -5.091 17.18046.9671.000 15.73ANISOU 575 CA ARG 74 937 1986 3053 16927-174ATOM576 CB ARG 74 -5.655 16.53745.7041.000 16.53ANISOU 576 CB ARG 74 1711 1434 3137 -263 142 -160ATOM577 CG ARG 74 -4.911 16.93444.4401.000 15.01ANISOU 577 CG ARG 74 1270 1288 3144 -156 279 -554ATOM578 CD ARG 74 -5.683 16.54343.1851.000 16.10ANISOU 578 CD ARG 74 1967 1031 3120 268-92 -407ATOM579 NE ARG 74 -4.902 16.81641.9661.000 18.81ANISOU 579 ME ARG 74 2259 1813 3075 -432 -252 -296ATOM580 CZ ARG 74 -5.033 17.82441.1301.000 16.64ANISOU 580 CZARG 74 19681646 2709 -141 -190 -596ATOM581 NH1 ARG 74 -5.951 18.77541.2931.000 20.09ANISOU 581 NH1 ARG 74 18992075 3660 54 -353 -788ATOM582 NH2 ARG 74 -4.220 17.89640.0681.000 20.12ANISOU 582 NH2 ARG 74 23662844 2437 153-196 -400ATOM583 C ARG 74 -5.373 18.68146.9661.000 12.70ANISOU 583 C ARG 74 11871880 1758 6 -22 -136ATOM584 O ARG 74 -4.501 19.46546.5821.000 14.07ANISOU 584 O ARG 74 10492048 2247 -221 -170 -480ATOM585 N ARG 75 -6.567 19.09947.3871.000 12.72ANISOU 585 N ARG 75 14021702 1728 95 182 -108ATOM586 CAARG 75 -7.006 20.47147.3081.000 13.40ANISOU 586 CAARG 75 19241618 1548 87 275 -193ATOM587 CBARG 75 -7.737 20.78445.9951.000 13.45ANISOU 587 CBARG 75 19721387 1751 -179 51-9ATOM588 CGARG 75 -6.908 20.63744.7211.000 13.38ANISOU 588 CGARG 75 16381851 1594 78 -217 101ATOM589 CDARG 75 -5.849 21.70844.5821.000 12.85ANISOU 589 CDARG 75 15371602 1741 23762-15ATOM590 NEARG 75 -5.087 21.68543.3471.000 13.71ANISOU 590 NEARG 75 17081797 1705 18890-91ATOM591 CZARG 75 -3.984 21.03643.0131.000 12.46ANISOU 591 CZARG 75 13481656 1731 -8986117ATOM592 NH1 ARG 75 -3.418 20.24143.8941.000 14.64ANISOU 592 NH1 ARG 75 19331794 1834 186-91 65ATOM593 NH2 ARG 75 -3.444 21.16741.7941.000 13.72ANISOU 593 NH2 ARG 75 15102037 1667 -136 84-83ATOM594 C ARG 75 -7.948 20.78748.4751.000 12.74ANISOU 594 C ARG 75 14001656 1784 -209 214 -464ATOM595 O ARG 75 -8.780 19.94448.8181.000 14.60ANISOU 595 O ARG 75 13481926 2273 -427 156 -480ATOM596 N GLY 76 -7.830 21.95549.0781.000 11.92ANISOU 596 N GLY 76 12681537 1724 -2234-389ATOM597 CAGLY 76 -8.801 22.39550.0701.000 12.44ANISOU 597 CAGLY 76 14391493 1796 -315 263 -412ATOM598 C GLY 76 -8.536 21.85751.4691.000 12.50ANISOU 598 C GLY 76 13241527 1900 5 326 -273ATOM599 O GLY 76 -7.388 21.51751.7691.000 14.25ANISOU 599 O GLY 76 11002099 2218 -277 239 -225ATOM600 N PHE 77 -9.574 21.84052.2871.000 12.65ANISOU 600 N PHE 77 11911806 1809 -162 231 -351ATOM601 CAPHE 77 -9.526 21.47453.6941.000 14.00ANISOU 601 CAPHE 77 12952110 1914 -260 276 -138ATOM602 CBPHE 77 -10.64422.22654.4511.000 14.73ANISOU 602 CBPHE 77 15542169 1874 -402 485 -317ATOM603 CGPHE 77 -10.77321.82455.9121.000 17.13ANISOU 603 CGPHE 77 19272730 1849 -374 378 -243ATOM604 CD1 PHE 77 -9.949 22.36956.8861.000 19.49ANISOU 604 CD1 PHE 77 27442700 1962 -119 219 -789ATOM605 CD2 PHE 77 -11.73020.90256.3091.000 19.13ANISOU 605 CD2 PHE 77 23483068 1852 -501 864 -165ATOM606 CE1 PHE 77 -10.06821.97358.2171.000 19.75ANISOU 606 CE1 PHE 77 29562381 2168 -174 -313 -304ATOM607 CE2 PHE 77 -11.82920.47957.6271.000 18.73ANISOU 607 CE2 PHE 77 25652711 1841 -382 310 -77ATOM608 CZPHE 77 -10.98621.01358.5841.000 19.22ANISOU 608 CZPHE 77 23782542 2382 98 13-364ATOM609 C PHE 77 -9.668 19.97653.9241.000 13.73ANISOU 609 C PHE 77 13062096 1813 -368 21-204ATOM610 O PHE 77 -10.52019.31353.2911.000 16.02ANISOU 610 O PHE 77 13862508 2194 -470 -128 -425ATOM611 NTHR 78 -8.869 19.43954.8521.000 14.33ANISOU 611 NTHR 78 15432270 1629 -472 35-49ATOM612 CA THR 78 -9.034 18.05355.2761.000 15.80ANISOU 612 CA THR 78 18132310 1880 -508 -23 82ATOM613 CB THR 78 -8.001 17.08154.6661.000 18.26ANISOU 613 CB THR 78 15832199 3158 -599 334 131ATOM614 OG1 THR 78 -7.924 17.32353.2661.000 21.81ANISOU 614 OG1 THR 78 33511877 3057 -88943 -370ATOM615 CG2 THR 78 -8.419 15.63454.8881.000 20.35ANISOU 615 CG2 THR 78 28552254 2622 -1119 1108 -707ATOM616 CTHR 78 -8.832 17.88156.7771.000 19.14ANISOU 616 CTHR 78 28452479 1948 -1747 -471 169ATOM617 OTHR 78 -7.801 18.31157.2901.000 22.04ANISOU 617 OTHR 78 27812889 2704 -1718 -985 763ATOM618 NGLY 79 -9.730 17.20357.4841.000 19.20ANISOU 618 NGLY 79 26292823 1844 -1352 1945ATOM619 CA GLY 79 -9.429 16.69558.8191.000 16.69ANISOU 619 CA GLY 79 18002770 1771 -518 196 -95ATOM620 CGLY 79 -8.672 15.37658.7201.000 22.98ANISOU 620 CGLY 79 23812874 3477 -272 -289 -545ATOM621 OGLY 79 -9.227 14.50458.0441.000 25.57ANISOU 621 OGLY 79 36832520 3514 -456 -974 -141ATOM622 NLEU 80 -7.494 15.23659.3191.000 22.91ANISOU 622 NLEU 80 24122900 3392 30 -206 -606ATOM623 CA LEU 80 -6.644 14.08159.0721.000 25.08ANISOU 623 CA LEU 80 28482777 3904 206621 361ATOM624 CLEU 80 -6.372 13.29460.3701.000 24.30ANISOU 624 CLEU 80 28342762 3637 -300 480 200ATOM625 OLEU 80 -5.729 13.81261.2911.000 25.14ANISOU 625 OLEU 80 22533017 4283 27 145 -5ATOM626 CB LEU 80 -5.318 14.48058.4151.000 27.16ANISOU 626 CB LEU 80 30573326 3937 379918 641ATOM627 CG LEU 80 -4.411 13.33857.9331.000 29.43ANISOU 627 CG LEU 80 34743505 4204 2871260 173ATOM628 CD1 LEU 80 -5.145 12.43856.9561.000 38.31ANISOU 628 CD1 LEU 80 56733891 4993 -1554 1987 -287ATOM629 CD2 LEU 80 -3.137 13.88457.3061.000 29.85ANISOU 629 CD2 LEU 80 35023919 3920 1251307 -264ATOM630 NGLU 81 -6.853 12.05560.3961.000 25.58ANISOU 630 NGLU 81 24692759 4490 -196 -82 510ATOM631 CA GLU 81 -6.739 11.03861.4151.000 25.98ANISOU 631 CA GLU 81 27392692 4441 -258 -55 424ATOM632 CGLU 81 -5.299 10.53661.5621.000 26.28ANISOU 632 CGLU 81 28703268 3848 187407 841ATOM633 OGLU 81 -4.489 10.65560.6551.000 28.19ANISOU 633 OGLU 81 37093520 3483 253799 -544ATOM634 CB GLU 81 -7.685 9.861 61.1231.000 29.83ANISOU 634 CB GLU 81 35332894 4906 -770 270 181ATOM635 CG GLU 81 -7.241 8.832 60.0981.000 25.34ANISOU 635 CG GLU 81 17372915 4976 284-1220 158ATOM636 CD GLU 81 -7.568 9.156 58.6491.000 27.00ANISOU 636 CD GLU 81 18413405 5012 475-1887 -456ATOM637 OE1 GLU 81 -8.120 10.24058.3241.000 28.81ANISOU 637 OE1 GLU 81 34443091 4413 322-155 791ATOM638 OE2 GLU 81 -7.240 8.273 57.8141.000 31.31ANISOU 638 OE2 GLU 81 35143384 4999 162352 100ATOM639 NSER 82 -4.988 9.974 62.7201.000 31.00ANISOU 639 NSER 82 35683780 4430 -65-30 1484ATOM640 CA SER 82 -3.653 9.422 62.9591.000 30.29ANISOU 640 CA SER 82 36923278 4540 -157 -515 1011ATOM641 CSER 82 -3.421 8.150 62.1501.000 31.76ANISOU 641 CSER 82 3995 32414831 -102 -1104 847ATOM642 OSER 82 -4.313 7.728 61.3971.000 34.01ANISOU 642 OSER 82 3193 37945935 458-1188 134ATOM643 CB SER 82 -3.463 9.167 64.4521.000 34.74ANISOU 643 CB SER 82 4687 39074606 -232 -979 971ATOM644 OG SER 82 -2.360 8.305 64.6811.000 41.53ANISOU 644 OG SER 82 4922 53665490 236-1958 970ATOM645 NGLY 91 -17.230 9.498 70.1361.000 42.64ANISOU 645 NGLY 91 4516 75994086 -2166 2340 -427ATOM646 CA GLY 91 -17.485 10.892 69.7891.000 44.91ANISOU 646 CA GLY 91 6666 77022697 -4311 -1561 565ATOM647 CGLY 91 -16.227 11.662 69.4521.000 38.67ANISOU 647 CGLY 91 5455 75871652 -2821 -274 -159ATOM648 OGLY 91 -15.164 11.480 70.0401.000 32.45ANISOU 648 OGLY 91 4241 44743616 -183 1152 -439ATOM649 NGLY 92 -16.332 12.558 68.4741.000 31.97ANISOU 649 NGLY 92 3881 59042363 -1382 735 -571ATOM650 CA GLY 92 -15.232 13.412 68.0751.000 33.02ANISOU 650 CA GLY 92 4121 61502274 -1716 851 -956ATOM651 CGLY 92 -15.223 13.696 66.5721.000 26.22ANISOU 651 CGLY 92 2603 50462314 -885 741 -947ATOM652 OGLY 92 -16.289 13.666 65.9391.000 23.91ANISOU 652 OGLY 92 2490 33963198 -680 548 -567ATOM653 NSER 93 -14.010 13.956 66.0881.000 23.77ANISOU 653 NSER 93 2405 39172708 -372 736 -560ATOM654 CA SER 93 -13.801 14.287 64.6901.000 23.41ANISOU 654 CA SER 93 2700 32922901 -386 970 -399ATOM655 CSER 93 -12.410 13.852 64.2401.000 24.26ANISOU 655 CSER 93 2547 39082763 -286 833 -224ATOM656 OSER 93 -11.497 13.831 65.0891.000 27.06ANISOU 656 OSER 93 3401 35363346 63092-386ATOM657 CB SER 93 -13.966 15.795 64.4671.000 25.71ANISOU 657 CB SER 93 2811 32253735 -576 271 -506ATOM658 OG SER 93 -13.558 16.158 63.1501.000 28.14ANISOU 658 OG SER 93 2694 37134284 -373 290 517ATOM659 NTYR 94 -12.254 13.533 62.9491.000 24.24ANISOU 659 NTYR 94 2786 33203104 -204 791 -817ATOM660 CA TYR 94 -10.878 13.262 62.4981.000 23.94ANISOU 660 CA TYR 94 3089 25023505 95 1112 -683ATOM661 CTYR 94 -10.017 14.531 62.5841.000 25.19ANISOU 661 CTYR 94 2601 26574312 147737 -625ATOM662 OTYR 94 -8.786 14.421 62.6941.000 30.11ANISOU 662 OTYR 94 2617 30955726 307760 36ATOM663 CB TYR 94 -10.800 12.659 61.0981.000 25.64ANISOU 663 CB TYR 94 3566 29103267 -293 1331 -525ATOM664 CG TYR 94 -11.600 11.410 60.8761.000 23.22ANISOU 664 CG TYR 94 3359 27682697 -69784 -274ATOM665 CD1 TYR 94 -12.451 11.455 59.7771.000 26.01ANISOU 665 CD1 TYR 94 4410 27302741 499353 -543ATOM666 CD2 TYR 94 -11.564 10.252 61.6351.000 24.42ANISOU 666 CD2 TYR 94 3117 28663297 73 458 -14ATOM667 CE1 TYR 94 -13.243 10.407 59.4431.000 28.75ANISOU 667 CE1 TYR 94 4559 33283037 434140 -1370ATOM668 CE2 TYR 94 -12.375 9.159 61.3051.000 26.47ANISOU 668 CE2 TYR 94 4707 25852764 -220 1227 -718ATOM669 CZ TYR 94 -13.209 9.247 60.2121.000 29.70ANISOU 669 CZ TYR 94 5641 35182125 -1172 1103 -1447ATOM670 OH TYR 94 -14.059 8.281 59.7301.000 34.02ANISOU 670 OH TYR 94 3079 39625886 -423 1593 -2638ATOM671 NSER 95 -10.628 15.714 62.5611.000 22.61ANISOU 671 NSER 95 2460 24973632 -5459-338ATOM 672 CA SER 95 -9.924 16.975 62.750 1.000 22.54ANISOU 672 CA SER 95 2257 26033706 -120 -301 46ATOM 673 C SER 95 -9.370 17.106 64.163 1.000 23.58ANISOU 673 C SER 95 1811 34783671 -521 -88 -85ATOM 674 O SER 95 -8.623 18.034 64.481 1.000 26.53ANISOU 674 O SER 95 2592 32424247 -469 -167 -641ATOM 675 CB SER 95 -10.838 18.177 62.478 1.000 27.58ANISOU 675 CB SER 95 3657 25564264 365-379 28ATOM 676 OG SER 95 -11.506 18.093 61.242 1.000 39.40ANISOU 676 OG SER 95 6336 42144421 900-1445 1442ATOM 677 N ASP 96 -9.712 16.194 65.060 1.000 25.04ANISOU 677 N ASP 96 2579 36883248 -399 277 -232ATOM 678 CA ASP 96 -9.228 16.317 66.422 1.000 24.42ANISOU 678 CA ASP 96 2603 33473330 -470 257 -526ATOM 679 C ASP 96 -7.735 16.050 66.501 1.000 24.45ANISOU 679 C ASP 96 2597 32283466 -471 162 -383ATOM 680 O ASP 96 -7.073 16.589 67.404 1.000 26.51ANISOU 680 O ASP 96 2656 40473370 -170 160 -798ATOM 681 CB ASP 96 -9.952 15.334 67.334 1.000 24.97ANISOU 681 CB ASP 96 2310 38063371 -423 -228 77ATOM 682 CG ASP 96 -11.411 15.605 67.606 1.000 26.77ANISOU 682 CG ASP 96 2272 43343566 -362 -240 716ATOM 683 OD1 ASP 96 -11.935 16.723 67.388 1.000 33.94ANISOU 683 OD1 ASP 96 3267 48944733 647204 569ATOM 684 OD2 ASP 96 -12.058 14.646 68.083 1.000 32.65ANISOU 684 OD2 ASP 96 3624 47094072 -1032 1446 -202ATOM 685 N TYR 97 -7.254 15.226 65.581 1.000 22.21ANISOU 685 N TYR 97 2292 33892760 -376 -77 -102ATOM 686 CA TYR 97 -5.835 14.852 65.583 1.000 23.71ANISOU 686 CA TYR 97 2480 35422987 -27106 644ATOM 687 C TYR 97 -5.026 15.828 64.743 1.000 23.06ANISOU 687 C TYR 97 2363 37542647 -410 -78 350ATOM 688 O TYR 97 -3.992 16.327 65.230 1.000 24.29ANISOU 688 O TYR 97 2205 38453178 -133 -230 74ATOM 689 CB TYR 97 -5.585 13.451 65.035 1.000 28.38ANISOU 689 CB TYR 97 3230 33244229 540-450 832ATOM 690 CG TYR 97 -4.132 13.025 65.082 1.000 30.37ANISOU 690 CG TYR 97 3278 41014161 766-191 671ATOM 691 CD1 TYR 97 -3.511 12.691 66.285 1.000 30.19ANISOU 691 CD1 TYR 97 2878 44754119 1106 151 951ATOM 692 CD2 TYR 97 -3.370 12.945 63.922 1.000 29.79ANISOU 692 CD2 TYR 97 3317 40053997 53 -253 544ATOM 693 CE1 TYR 97 -2.178 12.294 66.324 1.000 32.77ANISOU 693 CE1 TYR 97 2554 47715126 574-68 763ATOM 694 CE2 TYR 97 -2.043 12.553 63.955 1.000 32.68ANISOU 694 CE2 TYR 97 3536 37935087 403353 323ATOM 695 CZ TYR 97 -1.445 12.228 65.157 1.000 33.00ANISOU 695 CZ TYR 97 2633 42845622 1066 264 456ATOM 696 OH TYR 97 -0.121 11.845 65.156 1.000 42.66ANISOU 696 OH TYR 97 2572 53738264 1161 764 1277ATOM 697 CB SER 98 -3.465 16.575 62.134 1.000 23.20ANISOU 697 CB SER 98 2461 27663587 1052 -544ATOM 698 OG SER 98 -3.632 15.649 61.078 1.000 26.49ANISOU 698 OG SER 98 3824 30593180 -154 238 -457ATOM 699 C SER 98 -5.694 17.744 61.701 1.000 18.66ANISOU 699 C SER 98 2301 21502637 -295 6613ATOM 700 O SER 98 -6.768 17.212 61.413 1.000 20.88ANISOU 700 O SER 98 3042 22452646 -945 -249 181ATOM 701 N SER 98 -5.457 16.110 63.511 1.000 23.62ANISOU 701 N SER 98 2816 32272931 -441 -395 605ATOM 702 CA SER 98 -4.748 17.143 62.741 1.000 21.31ANISOU 702 CA SER 98 24302687 2982 133153 294ATOM703 N MET 99 -5.307 18.89161.1481.000 18.68ANISOU 703 N MET 99 23922722 1984 -978 -366 101ATOM704 CA MET 99 -6.047 19.56060.0751.000 17.84ANISOU 704 CA MET 99 24312620 1726 -945 -212 -17ATOM705 CB MET 99 -6.819 20.77960.5851.000 19.71ANISOU 705 CB MET 99 23482968 2173 -679 2564ATOM706 CG MET 99 -8.052 20.39261.3741.000 23.68ANISOU 706 CG MET 99 23603055 3582 -504 393 489ATOM707 SD MET 99 -9.031 21.82161.9111.000 22.33ANISOU 707 SD MET 99 25693383 2534 -522 170 -120ATOM708 CE MET 99 -8.148 22.22563.4191.000 36.98ANISOU 708 CE MET 99 64854165 3401 -225 -1904 -23ATOM709 C MET 99 -5.070 19.95458.9731.000 17.19ANISOU 709 C MET 99 22692488 1776 -960 -194 -201ATOM710 O MET 99 -3.964 20.34159.3241.000 16.93ANISOU 710 O MET 99 19322583 1919 -367 -208 -241ATOM711 N CYS 100-5.486 19.86457.7151.000 20.00ANISOU 711 N CYS 10031782683 1739 -1753 -358 166ATOM712 CA CYS 100-4.645 20.18156.5541.000 16.64ANISOU 712 CA CYS 10022132294 1817 -924 -563 468ATOM713 CB CYS 100-4.291 18.89355.8131.000 17.74ANISOU 713 CB CYS 10021612174 2407 560-765 1053ATOM714 SG CYS 100-3.035 18.92854.5521.000 33.56ANISOU 714 SG CYS 10052443511 3997 4141509 601ATOM715 C CYS 100-5.347 21.12155.5901.000 13.48ANISOU 715 C CYS 10018791415 1829 -68240 -91ATOM716 O CYS 100-6.585 21.12755.4961.000 14.49ANISOU 716 O CYS 10018801952 1673 -497 -57 14ATOM717 N TYR 101-4.589 21.92154.8521.000 13.35ANISOU 717 N TYR 10117211677 1673 -254 -78 49ATOM718 CA TYR 101-5.016 22.75353.7551.000 10.27ANISOU 718 CA TYR 101926 1498 1477 -15-141 -231ATOM719 CB TYR 101-5.102 24.26554.1241.000 13.60ANISOU 719 CB TYR 10116261513 2027 -48322 -236ATOM720 CG TYR 101-5.498 25.02552.8631.000 17.31ANISOU 720 CG TYR 10123731509 2694 -158 -103 193ATOM721 CD1TYR 101-6.815 25.06852.5191.000 16.38ANISOU 721 CD1TYR 1012464752 3006 190-227 55ATOM722 CE1TYR 101-7.307 25.71551.4121.000 17.01ANISOU 722 CE1TYR 1012755714 2993 -86-416 122ATOM723 CD2TYR 101-4.616 25.67952.0121.000 19.51ANISOU 723 CD2TYR 10130321533 2847 -1143 -594 475ATOM724 CE2TYR 101-5.065 26.32150.8721.000 20.96ANISOU 724 CE2TYR 10128021949 3211 238112 769ATOM725 CZ TYR 101-6.414 26.33450.5681.000 22.78ANISOU 725 CZ TYR 10132382291 3126 -1228 -919 624ATOM726 OH TYR 101-6.875 26.98649.4421.000 23.10ANISOU 726 OH TYR 10131413112 2522 -14-129 429ATOM727 C TYR 101-4.041 22.51852.5961.000 11.25ANISOU 727 C TYR 10112231398 1654 -323 103 -252ATOM728 O TYR 101-2.823 22.67752.7871.000 12.23ANISOU 728 O TYR 10111141750 1784 -87130 -20ATOM729 N SER 102-4.542 22.19051.4051.000 11.17ANISOU 729 N SER 10213551279 1611 -220 145 -263ATOM730 CA SER 102-3.752 21.80250.2351.000 10.46ANISOU 730 CA SER 10211441263 1568 62 -1-125ATOM731 CB SER 102-4.027 20.34349.9081.000 13.46ANISOU 731 CB SER 10216681212 2234 324105 -301ATOM732 OG SER 102-3.723 19.48751.0251.000 16.42ANISOU 732 OG SER 10222911313 2637 -122 -43 96ATOM733 C SER 102 -4.046 22.66849.0081.000 11.74ANISOU 733 C SER 102 13461500 1614 18 -39 -10ATOM734 O SER 102 -5.148 23.14848.7841.000 12.84ANISOU 734 O SER 102 14801410 1988 90 -66 249ATOM735 N MET 103 -3.004 22.87148.1871.000 12.33ANISOU 735 N MET 103 15541722 1409 -262 -10 -246ATOM736 CA MET 103 -3.188 23.60346.9381.000 12.92ANISOU 736 CA MET 103 16631681 1565 22 47-70ATOM737 CB MET 103 -3.215 25.12247.1791.000 17.51ANISOU 737 CB MET 103 24391634 2579 -363 812 -44ATOM738 CG MET 103 -1.929 25.80847.5491.000 20.07ANISOU 738 CG MET 103 25091470 3646 -538 688 376ATOM739 SD MET 103 -2.136 27.61447.6891.000 18.10ANISOU 739 SD MET 103 22351665 2975 -3 -334 -352ATOM740 CE MET 103 -2.365 28.06845.9911.000 18.09ANISOU 740 CE MET 103 23191457 3098 -187 -718 -214ATOM741 C MET 103 -2.152 23.22145.8921.000 12.57ANISOU 741 C MET 103 14201837 1519 119-53 238ATOM742 O MET 103 -1.120 22.57346.1751.000 12.57ANISOU 742 O MET 103 10941891 1792 -155 -165 276ATOM743 N GLY 104 -2.418 23.65044.6551.000 12.83ANISOU 743 N GLY 104 14931958 1422 237-124 -34ATOM744 CA GLY 104 -1.533 23.45943.5131.000 12.65ANISOU 744 CA GLY 104 10752188 1544 -93-37 242ATOM745 C GLY 104 -1.624 24.62242.5421.000 14.36ANISOU 745 C GLY 104 19091985 1561 -265 -294 142ATOM746 O GLY 104 -2.033 25.70042.9671.000 15.69ANISOU 746 O GLY 104 16282273 2060 163-197 213ATOM747 N THR 105 -1.242 24.39741.2761.000 14.52ANISOU 747 N THR 105 18292182 1504 -59-375 319ATOM748 CA THR 105 -1.218 25.45240.2791.000 15.27ANISOU 748 CA THR 105 19772223 1603 -105 -363 365ATOM749 CB THR 105 -0.359 25.08339.0391.000 15.61ANISOU 749 CB THR 105 19362122 1873 -37-106 554ATOM750 OG1THR 105 -0.884 23.87638.4461.000 16.16ANISOU 750 OG1THR 105 17382260 2140 217-285 151ATOM751 CG2THR 105 1.092 24.88239.3691.000 17.47ANISOU 751 CG2THR 105 19182871 1847 -293 -227 527ATOM752 C THR 105 -2.603 25.82839.7551.000 14.73ANISOU 752 C THR 105 19891694 1913 122-340 199ATOM753 O THR 105 -2.730 26.92139.1741.000 19.91ANISOU 753 O THR 105 25792355 2632 23 -437 1004ATOM754 N ALA 106 -3.587 24.96039.9131.000 16.57ANISOU 754 N ALA 106 18362413 2047 2 -260 661ATOM755 CA ALA 106 -4.975 25.16739.4651.000 14.94ANISOU 755 CA ALA 106 19751904 1798 105-456 365ATOM756 CB ALA 106 -5.054 24.94537.9651.000 17.75ANISOU 756 C8 ALA 106 20062862 1876 140-201 -32ATOM757 C ALA 106 -5.942 24.25140.2221.000 16.26ANISOU 757 C ALA 106 17102174 2293 327-127 491ATOM758 O ALA 106 -5.498 23.39841.0131.000 14.57ANISOU 758 O ALA 106 16221971 1945 213-21 337ATOM759 N ASP 107 -7.253 24.41040.0081.000 16.71ANISOU 759 N ASP 107 17682096 2485 540-22 304ATOM760 CA ASP 107 -8.310 23.63840.6331.000 16.10ANISOU 760 CA ASP 107 16962175 2246 51 -485 -14ATOM761 CB ASP 107 -8.231 22.17140.2111.000 17.09ANISOU 761 CB ASP 107 12992385 2808 144-203 -399ATOM762 CG ASP 107 -8.418 21.96638.7201.000 21.54ANISOU 762 CG ASP 107 23852894 2906 84 -317 -722ATOM763 OD1ASP 107 -9.452 22.44538.1891.000 23.92ANISOU 763 OD1 ASP 107 34472970 2672 698-753 -772ATOM 764 OD2 ASP 107 -7.563 21.31138.0801.000 24.88ANISOU 764 OD2 ASP 107 24964004 2954 105244 -679ATOM 765 C ASP 107 -8.285 23.78542.1601.000 14.16ANISOU 765 C ASP 107 12611918 2201 237-447 153ATOM 766 O ASP 107 -8.507 22.85042.9361.000 16.67ANISOU 766 O ASP 107 20171927 2390 -189 -193 97ATOM 767 N ASN 108 -8.027 25.02042.5981.000 15.34ANISOU 767 N ASN 108 20931866 1870 82 51239ATOM 768 CA ASN 108 -7.967 25.31444.0311.000 13.68ANISOU 768 CA ASN 108 14791823 1898 153107 257ATOM 769 CB ASN 108 -6.925 26.42044.2721.000 15.60ANISOU 769 CB ASN 108 15932026 2309 16 267 -98ATOM 770 CG ASN 108 -5.516 25.94243.9631.000 15.23ANISOU 770 CG ASN 108 15052141 2142 5 -53 2ATOM 771 OD1 ASN 108 -5.086 24.93244.5051.000 15.40ANISOU 771 OD1 ASN 108 14122442 1998 -5 -239 188ATOM 772 ND2 ASN 108 -4.823 26.67843.0941.000 16.96ANISOU 772 ND2 ASN 108 15932198 2652 339393 222ATOM 773 C ASN 108 -9.310 25.70844.6421.000 14.55ANISOU 773 C ASN 108 14711937 2120 261191 526ATOM 774 O ASN 108 -10.22226.17043.9581.000 16.89ANISOU 774 O ASN 108 18612336 2219 716-109 14ATOM 775 N LEU 109 -9.412 25.51245.9541.000 13.42ANISOU 775 N LEU 109 14581648 1994 179130 9ATOM 776 CA LEU 109 -10.60225.79646.7691.000 13.53ANIS0U 776 CA LEU 109 10942122 1923 -52-86 -256ATOM 777 CB LEU 109 -11.18724.49947.3311.000 14.50ANISOU 777 CB LEU 109 13821959 2169 119455 -468ATOM 778 CG LEU 109 -11.58023.38346.3701.000 15.21ANIS0U 778 CG LEU 109 15931785 2403 23563-342ATOM 779 CD1 LEU 109 -11.93122.08347.0891.000 18.26ANISOU 779 CD1 LEU 109 24601674 2806 382-414 -94ATOM 780 CD2 LEU 109 -12.78023.78345.5291.000 22.36ANISOU 780 CD2 LEU 109 30552391 3052 44 -1155 288ATOM 781 C LEU 109 -10.20326.79447.8401.000 13.54ANISOU 781 C LEU 109 11791989 1979 76 -116 -259ATOM 782 O LEU 109 -9.416 26.42848.7171.000 16.15ANISOU 782 O LEU 109 21962210 1730 -52-366 32ATOM 783 N PHE 110 -10.70628.02547.7861.000 16.11ANISOU 783 N PHE 110 13692042 2709 105-118 -288ATOM 784 CA PHE 110 -10.29829.07948.7321.000 17.05ANISOU 784 CA PHE 110 16261801 3050 -116 259 -362ATOM 785 CB PHE 110 -9.660 30.25947.9911.000 17.94ANISOU 785 CB PHE 110 14232366 3027 -290 228 -129ATOM 786 CG PHE 110 -8.425 29.97247.1651.000 20.32ANISOU 786 CG PHE 110 17022650 3368 -176 459 -385ATOM 787 CD1 PHE 110 -7.257 29.59847.7931.000 20.35ANISOU 787 CD1 PHE 110 18852462 3387 461573 -707ATOM 788 CD2 PHE 110 -8.405 30.11045.7891.000 20.31ANISOU 788 CD2 PHE 110 20732226 3419 512712 -264ATOM 789 CE1 PHE 110 -6.102 29.34747.0651.000 19.49ANISOU 789 CE1 PHE 110 19582116 3332 176749 -631ATOM 790 CE2 PHE 110 -7.288 29.84645.0501.000 20.65ANISOU 790 CE2 PHE 110 21582094 3596 758724 -321ATOM 791 CZ PHE 110 -6.118 29.49645.6941.000 19.43ANISOU 791 CZ PHE 110 19252131 3327 219542 -780ATOM 792 C PHE 110 -11.49529.55649.5381.000 17.08ANISOU 792 C PHE 110 17741806 2911 -74414 -111ATOM 793 O PHE 110 -12.56229.79248.9291.000 21.26ANISOU 793 O PHE 110 18492577 3650 405178 -448ATOM 794 N PRO 111 -11.406 29.717 50.851 1.000 19.41ANISOU 794 N PRO 111 2279 2110 2985-386 519 -314ATOM 795 CD PRO 111 -10.278 29.322 51.705 1.000 19.20ANISOU 795 CD PRO 111 2773 1880 2640-417 255 -514ATOM 796 CA PRO 111 -12.549 30.252 51.604 1.000 21.47ANISOU 796 CA PRO 111 3026 1924 3206-50 728 -635ATOM 797 CB PRO 111 -12.167 30.007 53.055 1.000 23.63ANISOU 797 CB PRO 111 3789 2054 3137334 776 -575ATOM 798 CG PRO 111 -10.775 29.535 53.100 1.000 22.33ANISOU 798 CG PRO 111 2767 2908 2809-1006 623 -414ATOM 799 C PRO 111 -12.828 31.739 51.433 1.000 23.88ANISOU 799 C PRO 111 3139 2049 388779-142 -479ATOM 800 O PRO 111 -13.919 32.194 51.834 1.000 26.77ANISOU 800 O PRO 111 3800 2818 3555992 -91 -397ATOM 801 N SER 112 -11.906 32.517 50.872 1.000 25.19ANISOU 801 N SER 112 3514 2269 3788-247 -856 282ATOM 802 CA SER 112 -12.300 33.919 50.631 1.000 26.43ANISOU 802 CA SER 112 2654 2655 4734496 1364 456ATOM 803 CB SER 112 -12.506 34.712 51.912 1.000 33.37ANISOU 803 CB SER 112 3122 3663 5895172 2582 -510ATOM 804 OG SER 112 -11.322 34.719 52.688 1.00O 36.94ANTSOU 804 OG SER 112 6530 2154 53511399 206 -415ATOM 805 C SER 112 -11.262 34.587 49.723 1.000 26.62ANISOU 805 C SER 112 2613 2546 49561021 1668 651ATOM 806 O SER 112 -10.219 34.029 49.414 1.000 22.81ANISOU 806 O SER 112 2241 2782 3645800 837 -400ATOM 807 N GLY 113 -11.570 35.802 49.279 1.000 28.93ANISOU 807 N GLY 113 2937 2947 51081008 1175 1198ATOM 808 CA GLY 113 -10.659 36.478 48.365 1.000 30.79ANISOU 808 CA GLY 113 2992 3606 5102381 798 1400ATOM 809 C GLY 113 -9.362 36.829 49.070 1.000 31.83ANISOU 809 C GLY 113 3297 3919 4878262 897 528ATOM 810 O GLY 113 -8.294 36.790 48.459 1.000 25.85ANISOU 810 O GLY 113 2920 2317 4585857 450 -203ATOM 811 N ASP 114 -9.479 37.145 50.365 1.000 29.56ANISOU 811 N ASP 114 3487 2877 4868866 1104 760ATOM 812 CA ASP 114 -8.257 37.463 51.122 1.000 26.15ANISOU 812 CA ASP 114 3189 2680 40661028 1584 542ATOM 813 CB ASP 114 -8.628 37.937 52.526 1.000 33.81ANISOU 813 CB ASP 114 5580 2697 45691774 1691 -240ATOM 814 CG ASP 114 -7.904 39.232 52.840 1.000 40.77ANISOU 814 CG ASP 114 6798 3734 4960719 693 -248ATOM 815 OD1 ASP 114 -8.330 40.277 52.295 1.000 48.61ANISOU 815 OD1 ASP 114 6014 2534 99201703 931 -913ATOM 816 OD2 ASP 114 -6.932 39.178 59.622 1.000 54.35ANISOU 816 OD2 ASP 114 5258 7609 7783-868 495 1602ATOM 817 C ASP 114 -7.310 36.281 51.231 1.000 23.05ANISOU 817 C ASP 114 2621 2102 4033444 1874 340ATOM 818 O ASP 114 -6.111 36.371 50.955 1.000 22.05ANISOU 818 O ASP 114 2423 2277 3677131 1411 -461ATOM 819 N PHE 115 -7.854 35.160 51.637 1.000 23.21ANISOU 819 N PHE 115 2945 1890 3984-130 1293 -228ATOM 820 CA PHE 115 -7.120 33.896 51.690 1.000 19.93ANISOU 820 CA PHE 115 2562 1908 9102-198 655 -294ATOM 821 CB PHE 115 -8.085 32.792 52.157 1.000 19.49ANISOU 821 CB PHE 115 2378 1754 327564881 -314ATOM 822 CG PHE 115 -7.523 31.445 52.540 1.000 17.25ANISOU 822 CG PHE 115 2053 1589 2912-56 348 -695ATOM 823 CD1 PHE 115 -7.637 30.951 53.833 1.000 19.00ANISOU 823 CD1 PHE 115 2728 1539 295073496 -683ATOM 824 CD2 PHE 115 -6.868 30.634 51.615 1.000 17.88ANISOU 824 CD2 PHE 115 1933 1931 2927 7 298 -810ATOM825 CE1 PHE 115 -7.10029.71154.1631.000 20.25ANISOU 825 CE1 PHE 115 2825 1825 3042 317341 -575ATOM826 CE2 PHE 115 -6.33829.41251.9551.000 19.11ANISOU 826 CE2 PHE 115 1865 2158 3237 336351 -885ATOM827 CZ PHE 115 -6.45228.93653.2331.000 19.39ANISOU 827 CZ PHE 115 2068 1910 3390 320248 -669ATOM828 CPHE 115 -6.50633.62450.3271.000 17.86ANISOU 828 CPHE 115 1964 1945 2878 61 344 16ATOM829 OPHE 115 -5.32433.31550.2711.000 17.34ANISOU 829 OPHE 115 1868 2107 2613 -132 179 157ATOM830 NGLU 116 -7.31033.68349.2631.000 18.21ANISOU 830 NGLU 116 1921 1934 3065 547281 62ATOM831 CA GLU 116 -6.84833.38747.9071.000 19.99ANISOU 831 CA GLU 116 2128 2618 2851 81 231 222ATOM832 CB GLU 116 -7.96833.60546.8841.000 18.61ANISOU 832 CB GLU 116 2058 1952 3060 231244 270ATOM833 CG GLU 116 -7.39833.37845.4821.000 18.61ANISOU 833 CG GLU 116 1813 2288 2971 295-32 -33ATOM834 CD GLU 116 -8.44233.23044.4121.000 22.40ANISOU 834 CD GLU 116 1908 3193 3410 -122 -278 -91ATOM835 OE1 GLU 116 -9.65433.27244.6781.000 30.82ANISOU 835 OE1 GLU 116 1793 4465 5452 273-414 -24ATOM836 OE2 GLU 116 -8.08533.06343.2251.000 30.24ANISOU 836 OE2 GLU 116 3333 5132 3026 382-658 327ATOM837 CGLU 116 -5.62034.21147.5351.000 18.82ANISOU 837 CGLU 116 2090 2069 2990 294119 487ATOM838 OGLU 116 -4.60533.70147.0491.000 17.41ANISOU 838 OGLU 116 2228 1780 2606 45 259 282ATOM839 NARG 117 -5.66035.50847.7771.000 21.02ANISOU 839 NARG 117 2313 2185 3487 408220 90ATOM840 CA ARG 117 -4.56036.42047.4311.000 21.35ANISOU 840 CA ARG 117 2337 1800 3976 466147 -31ATOM841 CARG 117 -3.29136.05448.1921.000 20.52ANISOU 841 CARG 117 2292 2124 3380 353288 -10ATOM842 OARG 117 -2.18635.96947.6361.000 18.96ANISOU 842 OARG 117 2223 1664 3316 138318 231ATOM843 CB ARG 117 -4.97137.88547.6931.000 25.59ANISOU 843 CB ARG 117 3237 1900 4587 9291882 632ATOM844 CG ARG 117 -3.88138.90847.4781.000 32.57ANISOU 844 CG ARG 117 5212 1925 5237 -281 1083 623ATOM845 CD ARG 117 -4.32540.32347.8591.000 36.56ANISOU 845 CD ARG 117 6009 2157 5724 1491774 663ATOM846 NE ARG 117 -5.16240.33549.0561.000 44.43ANISOU 846 NE ARG 117 7200 3742 5940 -962344 -15ATOM847 CZ ARG 117 -4.76340.50150.3061.000 45.48ANISOU 847 CZ ARG 117 6422 4804 6054 -370 2388 -283ATOM848 NH1 ARG 117 -3.48440.68350.6191.000 53.21ANISOU 848 NH1 ARG 117 6867 6451 6900 -2543 2487 354ATOM849 NH2 ARG 117 -5.64740.48751.3011.000 50.00ANISOU 849 NH2 ARG 117 6265 6511 6220 2242433 -1534ATOM850 NILE 118 -3.43935.83249.4931.000 19.30ANISOU 850 NILE 118 2275 1838 3221 128407 -645ATOM851 CA ILE 118 -2.27535.52750.3311.000 18.25ANISOU 851 CA ILE 118 2376 1745 2811 78 530 -449ATOM852 CB ILE 118 -2.66535.59751.8201.000 18.24ANISOU 852 CB ILE 118 2201 1726 3003 346906 -306ATOM853 CG2 ILE 118 -1.71234.85152.7321.000 18.49ANISOU 853 CG2 ILE 118 2077 2158 2792 -202 308 -530ATOM854 CG1 ILE 118 -2.87737.03152.3681.000 24.69ANISOU 854 CG1 ILE 118 4436 1808 3136 2841382 -414ATOM855 CD1 ILE 118 -3.786 37.02553.5821.000 29.63ANISOU 855 CD1 ILE 118 61693096 1994 1891258 -1068ATOM856 CILE 118 -1.692 34.17249.9591.000 15.65ANISOU 856 CILE 118 23161549 2082 -89573 -117ATOM857 OILE 118 -0.463 34.03549.8021.000 14.59ANISOU 857 OILE 118 22401255 2051 16 286 214ATOM858 NTRP 119 -2.523 33.13949.7841.000 14.44ANISOU 858 NTRP 119 21251592 1771 47 128 -71ATOM859 CA TRP 119 -2.010 31.79549.5181.000 13.68ANISOU 859 CA TRP 119 17121529 1957 -61220 40ATOM860 CB TRP 119 -3.089 30.75549.9321.000 14.93ANISOU 860 CB TRP 119 18191729 2123 -234 295 -35ATOM861 CG TRP 119 -2.864 30.48251.4201.000 16.19ANISOU 861 CG TRP 119 16402364 2146 -168 582 167ATOM862 CD2 TRP 119 -2.116 29.43051.9931.000 20.41ANISOU 862 CD2 TRP 119 31892414 2151 202523 405ATOM863 CE2 TRP 119 -2.177 29.58053.3921.000 19.84ANISOU 863 CE2 TRP 119 35361818 2184 -439 234 137ATOM864 CE3 TRP 119 -1.390 28.35751.4561.000 23.94ANISOU 864 CE3 TRP 119 53821647 2068 561126 400ATOM865 CD1 TRP 119 -3.340 31.22352.4601.000 20.05ANISOU 865 CD1 TRP 119 32072343 2069 -9 189 -139ATOM866 NE1 TRP 119 -2.938 30.68953.6491.000 20.32ANISOU 866 NE1 TRP 119 28062726 2188 -96-68 -185ATOM867 CZ2 TRP 119 -1.547 28.71454.2811.000 22.12ANISOU 867 CZ2 TRP 119 40712256 2078 -17105 22ATOM868 CZ3 TRP 119 -0.761 27.49052.3321.000 21.52ANISOU 868 CZ3 TRP 119 42142168 1794 311-193 197ATOM869 CH2 TRP 119 -0.847 27.67453.7151.000 24.34ANISOU 869 CH2 TRP 119 53492047 1850 329148 183ATOM870 CTRP 119 -1.521 31.63448.0951.000 14.27ANISOU 870 CTRP 119 21801259 1985 -187 334 -65ATOM871 OTRP 119 -0.569 30.86547.8551.000 14.73ANISOU 871 OTRP 119 19961653 1946 -67362 101ATOM872 NTHR 120 -2.109 32.32547.1161.000 13.99ANISOU 872 NTHR 120 22311237 1848 106627 -137ATOM873 CA THR 120 -1.541 32.27545.7621.000 15.19ANISOU 873 CA THR 120 19032093 1774 9 435 -242ATOM874 CB THR 120 -2.492 32.98344.7871.000 16.41ANISOU 874 CB THR 120 19342304 1995 -331 152 66ATOM875 OG1 THR 120 -3.738 32.29744.7661.000 18.53ANISOU 875 OG1 THR 120 18912288 2863 -236 195 407ATOM876 CG2 THR 120 -1.974 32.90643.3581.000 18.02ANISOU 876 CG2 THR 120 21352602 2108 324322 318ATOM877 CTHR 120 -0.145 32.87045.7271.000 14.19ANISOU 877 CTHR 120 18682050 1475 87 285 -167ATOM878 OTHR 120 0.756 32.29945.0781.000 13.62ANISOU 878 OTHR 120 18641692 1620 301354 217ATOM879 NGLN 121 0.114 33.96246.4291.000 14.55ANISOU 879 NGLN 121 17211672 2136 304175 -67ATOM880 CA GLN 121 1.459 34.54846.4831.000 15.80ANISOU 880 CA GLN 121 20671666 2271 -18-119 362ATOM881 CGLN 121 2.465 33.64247.1761.00O 13.73ANISOU 881 CGLN 121 17471665 1806 -3018114ATOM882 OGLN 121 3.603 33.45246.6851.000 15.36AMISOU 882 OGLN 121 20631688 2084 48 360 -44ATOM883 CB GLN 121 1.315 35.91847.1541.000 18.85ANISOU 883 CB GLN 121 25371426 3200 -73-5356ATOM884 CG GLN 121 2.639 36.55847.5431.000 18.88ANISOU 884 CG GLN 121 25071788 2878 59 9 -248ATOM885 CD GLN 121 3.468 36.93646.3371.000 20.70ANISOU 885 CD GLN 121 2584 2138 3142 -373 -85 231ATOM886 OE1 GLN 121 2.935 37.08845.2241.000 22.47ANISOU 886 OE1 GLN 121 2695 2822 3019 -245 0 121ATOM887 NE2 GLN 121 4.779 37.10146.5221.000 25.22ANISOU 887 NE2 GLN 121 2426 3344 3811 127-131 1385ATOM888 NTYR 122 2.081 33.05448.2991.000 12.26ANISOU 888 NTYR 122 1747 1514 1399 99 -55 -258ATOM889 CA TYR 122 2.896 32.10249.0501.000 13.18ANISOU 889 CA TYR 122 1901 1643 1464 -20-253 -160ATOM890 CB TYR 122 2.211 31.72450.3641.000 13.78ANISOU 890 CB TYR 122 2045 1435 1756 11648-28ATOM891 CG TYR 122 2.994 30.80851.2821.000 14.22ANISOU 891 CG TYR 122 1966 1681 1758 10168101ATOM892 CD1 TYR 122 4.271 31.12051.7221.000 17.48ANISOU 892 CD1 TYR 122 1788 1972 2882 149-5420ATOM893 CE1 TYR 122 5.003 30.28452.5761.000 18.55ANISOU 893 CE1 TYR 122 2131 2050 2868 102-404 251ATOM894 CD2 TYR 122 2.445 29.61951.7311.000 20.72ANISOU 894 CD2 TYR 122 3308 1366 3197 -519 -1524 323ATOM895 CE2 TYR 122 3.140 28.77352.5741.000 25.40ANISOU 895 CE2 TYR 122 3772 1812 4067 -782 -2084 873ATOM896 CZ TYR 122 4.413 29.10152.9921.000 20.93ANISOU 896 CZ TYR 122 2985 1742 3224 -96-1145 313ATOM897 OH TYR 122 5.068 28.23053.8261.000 29.87ANISOU 897 OH TYR 122 4830 1998 4522 -680 -3078 621ATOM898 CTYR 122 3.218 30.87648.2091.000 12.33ANISOU 898 CTYR 122 1833 1412 1439 89 -218 88ATOM899 OTYR 122 4.395 30.50748.1171.000 14.25ANISOU 899 OTYR 122 1896 1861 1656 339-242 216ATOM900 NPHE 123 2.224 30.26947.5731.000 11.28ANISOU 900 NPHE 123 1950 1297 1041 6 -151 185ATOM901 CA PHE 123 2.482 29.15146.6651.000 12.08ANISOU 901 CA PHE 123 1731 1219 1640 64 -60 26ATOM902 CB PHE 123 1.139 28.71946.0241.000 13.86ANISOU 902 CB PHE 123 2048 1550 1666 -104 -276 -82ATOM903 CG PHE 123 1.311 27.51645.0991.000 14.44ANISOU 903 CG PHE 123 2173 1677 1637 142-475 -94ATOM904 CD1 PHE 123 1.281 26.23445.6141.000 13.64ANISOU 904 CD1 PHE 123 1857 1563 1764 -42-702 -236ATOM905 CD2 PHE 123 1.511 27.66443.7291.000 13.81ANISOU 905 CD2 PHE 123 1450 2164 1634 -420 -295 -248ATOM906 CE1 PHE 123 1.468 25.14144.7951.000 17.16ANISOU 906 CE1 PHE 123 2282 1819 2418 130-855 -644ATOM907 CE2 PHE 123 1.715 26.55942.9161.000 18.31ANISOU 907 CE2 PHE 123 2098 2657 2201 -1053 172 -845ATOM908 CZ PHE 123 1.706 25.29543.4451.000 16.71ANISOU 908 CZ PHE 123 1442 2382 2526 -36-306 -1077ATOM909 CPHE 123 3.489 29.51145.5811.000 13.48ANISOU 909 CPHE 123 2004 1472 1645 236157 18ATOM910 OPHE 123 4.424 28.76845.2421.000 13.07ANISOU 910 OPHE 123 1591 1498 1876 42 -78 -172ATOM911 NASP 124 3.294 30.68444.9481.000 13.83ANISOU 911 NASP 124 1490 1575 2189 51 207 288ATOM912 CA ASP 124 4.207 31.03643.8611.000 13.75ANISOU 912 CA ASP 124 1505 1330 2389 458398 344ATOM913 CB ASP 124 3.708 32.35243.2421.000 18.95ANISOU 913 CB ASP 124 2650 1970 2580 656-63 926ATOM914 CG ASP 124 4.470 32.70841.9891.000 27.54ANISOU 914 CG ASP 124 5327 2099 3036 -123 939 880ATOM915 OD1 ASP 124 4.541 31.90441.0231.000 37.04ANISOU 915 OD1 ASP 124 6362 3225 4485 1082616 -331ATOM916 OD2 ASP 124 4.985 33.84342.0111.000 32.60ANISOU 916 OD2 ASP 124 4724 3509 4151 -1539 234 851ATOM917 CASP 124 5.645 31.16444.3281.000 14.49ANISOU 917 CASP 124 1493 1721 2293 327485 482ATOM918 OASP 124 6.591 30.72143.6741.000 14.52ANISOU 918 OASP 124 1477 1363 2679 289497 307ATOM919 NARG 125 5.866 31.77745.4991.000 14.03ANISOU 919 NARG 125 1501 1271 2558 353398 414ATOM920 CA ARG 125 7.214 31.86346.0441.000 16.40ANISOU 920 CA ARG 125 1642 1625 2963 194178 226ATOM921 CARG 125 7.828 30.49446.3461.000 14.69ANISOU 921 CARG 125 1396 1688 2496 232-25 153ATOM922 OARG 125 8.999 30.24546.0341.000 14.10ANISOU 922 OARG 125 1279 1656 2424 7 -205 -201ATOM923 CB ARG 125 7.213 32.70547.3181.000 18.13ANISOU 923 CB ARG 125 1950 1902 3035 787-81 46ATOM924 CG ARG 125 7.045 34.19347.0411.000 23.51ANISOU 924 CG ARG 125 2232 1780 4919 863-36 -225ATOM925 CD ARG 125 8.391 34.81546.6941.000 29.33ANISOU 925 CD ARG 125 3596 2824 4724 -667 237 -187ATOM926 NE ARG 125 8.194 36.26246.8031.000 32.99ANISOU 926 NE ARG 125 4350 2766 5418 -678 -1642 156ATOM927 CZ ARG 125 8.868 37.15347.4951.000 27.38ANISOU 927 CZ ARG 125 2292 2758 5353 -276 -580 -246ATOM928 NH1 ARG 125 9.916 36.82148.2351.000 38.55ANISOU 928 NH1 ARG 125 4611 3604 6433 449-2476 -669ATOM929 NH2 ARG 125 8.491 38.42347.4421.000 30.26ANISOU 929 NH2 ARG 125 4062 2570 4865 -369 -835 363ATOM930 NGLN 126 7.065 29.57346.9201.000 12.36ANISOU 930 NGLN 126 1316 1376 2002 248-63 -264ATOM931 CA GLN 126 7.524 28.20147.1531.000 13.39ANISOU 931 CA GLN 126 1765 1323 1999 219-355 -377ATOM932 CB AGLN 126 6.363 27.45547.8280.500 16.24ANISOU 932 CB AGLN 126 2422 1391 2357 188202 -192ATOM933 CG AGLN 126 6.149 27.75849.2840.500 18.83ANISOU 933 CG AGLN 126 2761 2021 2371 68 233 -210ATOM934 CD AGLN 126 7.077 27.14650.2980.500 23.94ANISOU 934 CD AGLN 126 3578 2745 2774 -604 -757 33ATOM935 OE1 AGLN 126 7.181 27.68351.4190.500 35.94ANISOU 935 OE1 AGLN 126 6788 3731 3136 -578 -1567 -478ATOM936 NE2 AGLN 126 7.774 26.05550.0080.500 24.63ANISOU 936 NE2 AGLN 126 4491 1118 3751 -881 -2407 462ATOM937 CB BGLN 126 6.525 27.41748.0180.500 13.36ANISOU 937 CB BGLN 126 1695 1137 2245 602-114 -255ATOM938 CG BGLN 126 6.604 27.75049.4970.500 18.28ANISOU 938 CG BGLN 126 2537 2257 2153 -68-176 -105ATOM939 CD BGLN 126 5.442 27.23750.3190.500 18.42ANISOU 939 CD BGLN 126 2227 2573 2198 344-159 106ATOM940 OE1 BGLN 126 5.605 26.44251.2420.500 25.36ANISOU 940 OE1 BGLN 126 3289 3517 2828 -100 -223 953ATOM941 NE2 BGLN 126 4.231 27.68550.0030.500 25.02ANISOU 941 NE2 BGLN 126 2427 2669 4413 1004 -83 -298ATOM942 CGLN 126 7.860 27.44845.8611.000 12.95ANISOU 942 CGLN 126 1506 1434 1979 307-372 -366ATOM943 OGLN 126 8.859 26.72145.7481.000 11.66ANISOU 943 OGLN 126 1461 1142 1827 182 -85159ATOM944 NTYR 127 6.960 27.57844.8681.000 11.61ANISOU 944 NTYR 127 1400 1276 1735 146-168 -10ATOM945 CA TYR 127 7.152 26.86943.5851.000 11.21ANISOU 945 CA TYR 127 1469 1242 1550 -92-40 192ATOM946 CB TYR 127 5.901 26.94042.7241.000 11.82ANISOU 946 CB TYR 127 13461655 1491 -138247ATOM947 CG TYR 127 5.791 26.06941.4961.000 11.49ANISOU 947 CG TYR 127 12781428 1660 -4 -410ATOM948 CD1TYR 127 6.550 24.92841.2701.000 11.28ANISOU 948 CD1TYR 127 10301334 1921 -87-100 33ATOM949 CE1TYR 127 6.406 24.15340.1151.000 11.47ANISOU 949 CE1TYR 127 11641167 2027 -51-53 21ATOM950 CD2TYR 127 4.871 26.41040.5001.000 11.98ANISOU 950 CD2TYR 127 16771093 1784 204-219 -100ATOM951 CE2TYR 127 4.715 25.65539.3571.000 11.37ANISOU 951 CE2TYR 127 15391118 1665 140-68 -73ATOM952 CZ TYR 127 5.494 24.50839.1631.000 11.02ANISOU 952 CZ TYR 127 12021226 1760 91 48-125ATOM953 OH TYR 127 5.379 23.72038.0301.000 11.57ANISOU 953 OH TYR 127 15471138 1712 94 177 -34ATOM954 C TYR 127 8.386 27.39242.8821.000 10.83ANISOU 954 C TYR 127 1296989 1830 230-43 378ATOM955 O TYR 127 9.185 26.60542.3751.000 10.86ANISOU 955 O TYR 127 12921232 1603 164-237 -42ATOM956 N THR 128 8.565 28.71642.8651.000 10.98ANISOU 956 N THR 128 1554976 1642 212-9557ATOM957 CA THR 128 9.766 29.30542.2951.000 11.80ANISOU 957 CA THR 128 16861125 1673 -47-169 386ATOM958 CB THR 128 9.605 30.84942.3781.000 12.66ANISOU 958 CB THR 128 18731074 1864 -52-233 521ATOM959 OG1THR 128 8.530 31.28641.5171.000 16.74ANISOU 959 OG1THR 128 22231597 2542 124-457 998ATOM960 CG2THR 128 10.878 31.51041.8931.000 16.54ANISOU 960 CG2THR 128 1871778 3635 262655 138ATOM961 C THR 128 11.040 28.82842.9641.000 11.26ANISOU 961 C THR 128 1562980 1738 -71-162 148ATOM962 O THR 128 11.995 28.45842.2581.000 12.16ANISOU 962 O THR 128 17691092 1758 17 26279ATOM963 N ALA 129 11.083 28.80244.3001.000 10.39ANISOU 963 N ALA 129 11831001 1763 70 -118 147ATOM964 CA ALA 129 12.273 28.38645.0371.000 10.59ANISOU 964 CA ALA 129 1206945 1873 -69-170 281ATOM965 CB ALA 129 12.113 28.60346.5361.000 12.46ANISOU 965 CB ALA 129 2113851 1769 82 -218 577ATOM966 C ALA 129 12.575 26.90644.8021.000 11.35ANISOU 966 C ALA 129 1258883 2170 -16-141 410ATOM967 O ALA 129 13.738 26.48544.6411.000 10.93ANISOU 967 O ALA 129 12021157 1796 -36-213 121ATOM968 N SER 130 11.519 26.08644.7501.000 12.27ANISOU 968 N SER 130 1280984 2398 -65-1-24ATOM969 CA SER 130 11.682 24.65044.5121.000 10.89ANISOU 969 CA SER 130 1623876 1638 -8544370ATOM970 CB ASER130 10.342 23.94044.7160.500 10.08ANISOU 970 CB ASER130 1432603 1793 213247 413ATOM971 OG ASER130 9.771 24.06346.0060.500 9.12ANISOU 971 OG ASER130 1021651 1792 91 1 -143ATOM972 CB BSER130 10.364 23.91944.7650.500 10.60ANISOU 972 CB BSER130 1687822 1521 -45318 158ATOM973 OG BSER130 9.418 24.09843.7340.500 16.22ANISOU 973 OG BSER130 17171289 3156 137-525 348ATOM974 C SER 130 12.214 24.37343.1101.000 10.53ANISOU 974 C SER 130 1586733 1684 -166 210 484ATOM975 O SER 130 13.137 23.53242.9421.000 11.17ANISOU 975 O SER 130 13851012 1849 -151 -95 140ATOM976 N ARG 131 11.680 25.04442.0791.000 10.46ANISOU 976 N ARG 131 1578861 1534 -87-66 99ATOM 977 CA ARG 131 12.260 24.839 40.742 1.000 10.60ANISOU 977 CA ARG 131 14801110 1438 61-288 82ATOM 978 CB ARG 131 11.426 25.553 39.679 1.000 12.99ANISOU 978 CB ARG 131 18931369 1673 63-525 276ATOM 979 CG ARG 131 10.003 25.065 39.431 1.000 13.64ANISOU 979 CG ARG 131 17071735 1742 335 -559 -86ATOM 980 CD ARG 131 9.349 25.669 38.206 1.000 17.71ANISOU 980 CD ARG 131 20781973 2677 81-983 701ATOM 981 NE ARG 131 9.453 27.113 38.015 1.000 19.76ANISOU 981 NE ARG 131 27162034 2757 -25 -525 713ATOM 982 CZ ARG 131 8.629 28.004 38.568 1.000 21.24ANISOU 982 CZ ARG 131 36881878 2503 -8-128 647ATOM 983 NH1 ARG 131 7.631 27.634 39.366 1.000 21.32ANISOU 983 NH1 ARG 131 27923142 2166 -486 -667 57ATOM 984 NH2 ARG 131 8.771 29.310 38.361 1.000 27.83ANISOU 984 NH2 ARG 131 46491822 4103 -90 -422 561ATOM 985 C ARG 131 13.714 25.323 40.688 1.000 10.42ANISOU 985 C ARG 131 15421078 1339 50-103 1ATOM 986 O ARG 131 14.568 24.683 40.080 1.000 10.94ANISOU 986 O ARG 131 15441105 1506 177 -134 42ATOM 987 N ALA 132 14.028 26.438 41.343 1.000 10.97ANISOU 987 N ALA 132 14771129 1563 74-364 -45ATOM 988 CA ALA 132 15.379 26.983 41.343 1.000 11.10ANISOU 988 CA ALA 132 15399441735 9 -102 97ATOM 989 CB ALA 132 15.429 28.344 42.048 1.000 12.82ANISOU 989 CB ALA 132 17111171 1987 -48 -248 -198ATOM 990 C ALA 132 16.393 26.045 41.995 1.000 11.55ANISOU 990 C ALA 132 10851107 2197 -197 305 745ATOM 991 O ALA 132 17.481 25.832 41.432 1.000 11.81ANISOU 991 O ALA 132 10811809 1599 -204 17-9ATOM 992 N VAL 133 16.061 25.490 43.175 1.000 11.16ANISOU 992 N VAL 133 12601356 1623 -148 51350ATOM 993 CA VAL 133 17.011 24.587 43.840 1.000 11.62ANISOU 993 CA VAL 133 15051529 1380 -69 -297 89ATOM 994 CB VAL 133 16.738 24.418 45.344 1.000 12.14ANISOU 994 CB VAL 133 13761674 1564 -74 -25 364ATOM 995 CG1 VAL 133 15.550 23.501 45.608 1.000 14.96ANISOU 995 CG1 VAL 133 17052316 1662 -706 8 -357ATOM 996 CG2 VAL 133 17.981 23.864 46.033 1.000 15.63ANISOU 996 CG2 VAL 133 17552340 1845 -341 -677 551ATOM 997 C VAL 133 17.079 23.268 43.065 1.000 11.71ANISOU 997 C VAL 133 13761363 1711 -24 -425 169ATOM 998 O VAL 133 18.198 22.733 42.925 1.000 11.55ANISOU 998 O VAL 133 13911453 1545 -4-116 398ATOM 999 N ALA 134 15.982 22.758 42.480 1.000 12.87ANISOU 999 N ALA 134 13991517 1973 28-334 -228ATOM 1000 CA ALA 134 16.084 21.557 41.621 1.000 10.57ANISOU 1000 CA ALA 134 11061220 1691 153 -298 96ATOM 1001 CB ALA 134 14.699 21.096 41.186 1.000 12.20ANISOU 1001 CB ALA 134 12541589 1794 35-303 -127ATOM 1002 C ALA 134 16.968 21.797 40.399 1.000 12.58ANISOU 1002 C ALA 134 13931399 1987 272 -4277ATOM 1003 O ALA 134 17.712 20.924 39.970 1.000 11.01AMISOU 1003 O ALA 134 12541358 1574 83-268 26ATOM 1004 N ARG 135 16.908 22.995 39.809 1.000 12.03ANISOU 1004 N ARG 135 15171230 1824 -62 -327 87ATOM 1005 CA ARG 135 17.773 23.353 38.676 1.000 13.23ANISOU 1005 CA ARG 135 18541158 2015 -270 -209 161ATOM 1006 CB ARG 135 17.393 24.734 38.170 1.000 14.57ANISOU 1006 CB ARG 135 22031339 1994 -45 -541 222ATOM 1007 CG ARG 135 17.753 25.160 36.797 1.000 19.22ANISOU 1007 CGARG135 4204 1120 1980 -490 -433 150ATOM1008 CDARG135 17.23726.56336.4711.000 22.14ANISOU 1008 CDARG135 4046 1500 2868 -159 315 822ATOM1009 NEARG135 15.83126.60736.0771.000 22.66ANISOU 1009 NEARG135 4239 1404 2965 -9447257ATOM1010 CZARG135 14.80227.18436.6841.000 21.69ANISOU 1010 CZARG135 4004 1906 2333 92 -506 64ATOM1011 NH1 ARG135 14.91727.84337.8331.000 22.26ANISOU 1011 NH1 ARG135 4114 2532 1812 460-833 341ATOM1012 NH2 ARG135 13.58227.11336.1491.000 22.31ANISOU 1012 NH2 ARG135 4000 2243 2234 -544 -419 8ATOM1013 C ARG135 19.25123.27539.0571.000 12.70ANISOU 1013 C ARG135 1742 1264 1821 -119 -16 430ATOM1014 O ARG135 20.06922.81838.2381.000 14.67ANISOU 1014 O ARG135 2133 1529 1910 19 169 391ATOM1015 N GLU136 19.57223.71240.2661.000 12.15ANISOU 1015 N GLU136 1423 1372 1820 -3670430ATOM1016 CAGLU136 20.96023.63040.7631.000 14.52ANISOU 1016 CAGLU136 1622 1701 2194 -90-197 371ATOM1017 CBGLU136 21.21224.51341.9811.000 15.59ANISOU 1017 CBGLU136 1502 1781 2642 14 -231 11ATOM1018 CGGLU136 21.06426.02041.7831.000 18.01ANISOU 1018 CGGLU136 2010 1762 3071 -232 -153 126ATOM1019 CDGLU136 21.79826.48440.5371.000 20.18ANISOU 1019 CDGLU136 2071 2079 3519 -308 89369ATOM1020 OE1 GLU136 22.98726.14840.3941.000 24.64ANISOU 1020 OE1 GLU136 2060 2937 4364 -262 338 615ATOM1021 OE2 GLU136 21.19527.15039.6701.000 24.19ANISOU 1021 OE2 GLU136 2479 2327 4385 -381 317 1426ATOM1022 C GLU136 21.36422.18641.0761.000 14.00ANISOU 1022 C GLU136 1338 1619 2361 -112 -442 223ATOM1023 O GLU136 22.50821.78140.8331.000 13.86ANISOU 1023 O GLU136 1366 1890 2009 -100 -287 329ATOM1024 N VAL137 20.47221.33841.5801.000 11.78ANISOU 1024 N VAL137 1309 1451 1715 148-223 85ATOM1025 CAVAL137 20.75319.89641.7711.000 12.49ANISOU 1025 CAVAL137 1369 1522 1853 240-69 289ATOM1026 CBVAL137 19.56019.16542.4291.000 12.41ANISOU 1026 CBVAL137 1422 1424 1869 -67-85 -204ATOM1027 CG1 VAL137 19.72817.63442.4011.000 12.55ANISOU 1027 CG1 VAL137 1371 1508 1892 182185 111ATOM1028 CG2 VAL137 19.35519.60743.8521.000 11.35ANISOU 1028 CG2 VAL137 1461 1281 1572 182-254 288ATOM1029 C VAL137 21.10019.24140.4351.000 12.48ANISOU 1029 C VAL137 1202 1428 2113 150-16 85ATOM1030 O VAL137 22.05718.46240.2871.000 13.03ANISOU 1030 O VAL137 1021 1683 2249 1491 146ATOM1031 N LEU138 20.30919.56239.4011.000 10.28ANISOU 1031 N LEU138 1198 881 1829 -15158 226ATOM1032 CALEU138 20.57119.02938.0661.000 12.48ANISOU 1032 CALEU138 1312 1408 2024 110273 -52ATOM1033 CBLEU138 19.39819.35837.1301.000 11.81AMISOU 1033 CBLEU138 1260 1586 1642 -20383 43ATOM1034 CGLEU138 18.03618.72637.4571.000 10.77ANISOU 1034 CGLEU138 1391 1397 1304 -83219 213ATOM1035 CD1 LEU138 16.91619.32436.5961.000 12.72ANISOU 1035 CD1 LEU138 1416 1587 1829 -59-25 173ATOM1036 CD2 LEU138 18.05217.20737.3201.000 14.32ANISOU 1036 CD2 LEU138 1986 1390 2063 -79296 370ATOM1037 C LEU138 21.90319.52537.5051.000 13.61ANISOU 1037 C LEU138 1305 2026 1840 -65174 5ATOM1038 O LEU138 22.695 18.76036.920 1.000 14.97ANISOU 1038 O LEU138 11252247 2313 105234 178ATOM1039 N ARG139 22.184 20.81637.614 1.000 13.26ANISOU 1039 N ARG139 14322046 1561 -155 219 317ATOM1040 CAARG139 23.397 21.37237.085 1.000 14.71ANISOU 1040 CAARG139 16481941 2000 -27502 447ATOM1041 C ARG139 24.636 20.81537.775 1.000 15.16ANISOU 1041 C ARG139 14252101 2235 -158 324 116ATOM1042 O ARG139 25.650 20.49537.166 1.000 18.15ANISOU 1042 O ARG139 16282581 2688 18 612 339ATOM1043 CBARG139 23.394 22.92637.206 1.000 19.67ANISOU 1043 CBARG139 17491923 3803 -196 186 252ATOM1044 CGARG139 24.418 23.48736.237 1.000 28.66ANISOU 1044 CGARG139 39242584 4383 -2305 882 -563ATOM1045 CDARG139 24.245 24.99736.111 1.000 39.58ANISOU 1045 CDARG139 68012389 5849 -3273 119 -306ATOM1046 NEARG139 24.910 25.66037.210 1.000 47.91ANISOU 1046 NEARG139 95482435 6222 -2157 -1331 -708ATOM1047 CZARG139 24.493 26.68237.928 1.000 45.42ANISOU 1047 CZARG139 69414516 5802 -882 -2118 -1238ATOM1048 NH1 ARG139 23.316 27.27337.722 1.000 64.33ANISOU 1048 NH1 ARG139 72488153 9039 93 -2965 -980ATOM1049 NH2 ARG139 25.309 27.10938.888 1.000 32.62ANISOU 1049 NH2 ARG139 50204758 2616 -2746 590 167ATOM1050 N ALA140 24.562 20.68439.096 1.000 14.85ANISOU 1050 N ALA140 12872204 2151 -517 -26 -46ATOM1051 CAALA140 25.730 20.25739.856 1.000 15.80ANISOU 1051 CAALA140 989 2649 2366 -309 -9-401ATOM1052 CBALA140 25.444 20.44241.330 1.000 19.36ANISOU 1052 CBALA140 26852447 2222 243-435 -480ATOM1053 C ALA140 26.111 18.80639.584 1.000 16.86ANISOU 1053 C ALA140 15552795 2054 12 -186 -458ATOM1054 O ALA140 27.258 18.40339.796 1.000 18.90ANISOU 1054 O ALA140 15382686 2958 -2160145ATOM1055 N THR141 25.147 18.02539.098 1.000 17.53ANISOU 1055 N THR141 17792532 2350 -528 218 -108ATOM1056 CATHR141 25.340 16.62538.765 1.000 15.59ANISOU 1056 CATHR141 12562401 2268 -192 -95 291ATOM1057 CBTHR141 24.207 15.73539.343 1.000 14.77ANISOU 1057 CBTHR141 12382200 2172 155282 301ATOM1058 OG1 THR141 22.946 16.16838.849 1.000 12.47ANISOU 1058 OG1 THR141 12491565 1926 -31295 476ATOM1059 CG2 THR141 24.167 15.81840.859 1.000 14.82ANISOU 1059 CG2 THR141 13942077 2160 135-47 177ATOM1060 C THR141 25.423 16.37437.257 1.000 16.11ANISOU 1060 C THR141 17322046 2343 303583 325ATOM1061 O THR141 25.432 15.23536.778 1.000 17.55ANISOU 1061 O THR141 19912104 2573 237555 249ATOM1062 N GLY142 25.474 17.41636.446 1.000 17.74ANISOU 1062 N GLY142 21272197 2416 303260 501ATOM1063 CAGLY142 25.611 17.26334.987 1.000 17.32ANISOU 1063 CAGLY142 16422494 2447 -160 453 517ATOM1064 C GLY142 24.426 16.55634.358 1.000 16.37ANISOU 1064 C GLY142 16191893 2710 261472 42ATOM1065 O GLY142 24.654 15.82433.379 1.000 18.43ANISOU 1065 O GLY142 22432558 2201 57 798 163ATOM1066 N THR143 23.232 16.73834.907 1.000 13.99ANISOU 1066 N THR143 15311429 2356 83 430 350ATOM1067 CATHR143 22.049 16.00334.472 1.000 14.69ANISOU 1067 CATHR143 17681591 2223 8 342 93ATOM1068 CBTHR143 21.208 15.58435.700 1.000 15.52ANISOU 1068 CB THR143 14571653 2785 55 419 529ATOM 1069 OG1 THR143 22.037 14.784 36.573 1.000 14.63ANISOU 1069 OG1 THR143 12961792 2471 52 434 369ATOM 1070 CG2 THR143 20.044 14.738 35.231 1.000 14.24ANISOU 1070 CG2 THR143 17611981 1669 3 379 192ATOM 1071 C THR143 21.135 16.785 33.532 1.000 13.96ANISOU 1071 C THR143 15531708 2044 128479 -131ATOM 1072 O THR143 20.642 17.828 33.923 1.000 15.65ANISOU 1072 O THR143 23741580 1995 315486 55ATOM 1073 N GLU144 20.928 16.279 32.322 1.000 15.32ANISOU 1073 N GLU144 17341904 2184 -156 260 -271ATOM 1074 CA GLU144 19.917 16.693 31.362 1.000 17.30ANISOU 1074 CA GLU144 16862470 2417 -377 152 106ATOM 1075 C GLU144 18.774 15.693 31.292 1.000 16.84ANISOU 1075 C GLU144 16332380 2386 -298 313 -242ATOM 1076 O GLU144 18.922 14.631 30.680 1.000 16.71ANISOU 1076 O GLU144 14702057 2821 -43610 58ATOM 1077 CB GLU144 20.539 16.856 29.970 1.000 21.91ANISOU 1077 CB GLU144 27473417 2162 -1508 31-8ATOM 1078 CG GLU144 19.568 17.063 28.825 1.000 37.93ANISOU 1078 CG GLU144 66524374 3385 -2057 -2082 1767ATOM 1079 CD GLU144 19.293 18.507 28.466 1.000 43.55ANISOU 1079 CD GLU144 78694258 4419 -2497 -2259 2129ATOM 1080 OE1 GLU144 19.602 19.365 29.326 1.000 51.81ANISOU 1080 OE1 GLU144 98434613 5230 -3180 -832 1126ATOM 1081 OE2 GLU144 18.766 18.798 27.367 1.000 40.12ANISOU 1081 OE2 GLU144 55516029 3662 -285 -115 2660ATOM 1082 N PRO145 17.620 15.959 31.908 1.000 14.29ANISOU 1082 N PRO145 16341364 2432 -4 208 265ATOM 1083 CD PRO145 17.256 17.136 32.718 1.000 14.14ANISOU 1083 CD PRO145 17351778 1859 -5532167ATOM 1084 CA PRO145 16.507 15.000 31.807 1.000 13.72ANISOU 1084 CA PRO145 14841391 2337 66 173 466ATOM 1085 CB PRO145 15.406 15.701 32.606 1.000 14.20ANISOU 1085 CB PRO145 14591636 2302 161-41 289ATOM 1086 CG PRO145 16.132 16.608 33.561 1.000 14.43ANISOU 1086 CG PRO145 17962007 1679 -23-42 449ATOM 1087 C PRO145 16.076 14.794 30.372 1.000 15.18ANISOU 1087 C PRO145 17451665 2359 -192 231 287ATOM 1088 O PRO145 16.178 15.685 29.509 1.000 15.40ANISOU 1088 O PRO145 24301511 1910 -85613 -15ATOM 1089 N ASP146 15.544 13.613 30.070 1.000 15.79ANISOU 1089 N ASP146 20191611 2367 -191 666 81ATOM 1090 CA ASP146 14.918 13.366 28.773 1.000 16.74ANISOU 1090 CA ASP146 20951759 2506 -348 575 -77ATOM 1091 CB ASP146 14.300 11.966 28.727 1.000 18.99ANISOU 1091 CB ASP146 25081729 2977 -323 780 -439ATOM 1092 CG ASP146 13.504 11.784 27.444 1.000 27.04ANISOU 1092 CG ASP146 40122450 3813 -720 -229 -805ATOM 1093 OD1 ASP146 12.295 12.121 27.409 1.000 38.65ANISOU 1093 OD1 ASP146 39434889 5852 -595 -1282 -323ATOM 1094 OD2 ASP146 14.091 11.311 26.466 1.000 39.95ANISOU 1094 OD2 ASP146 69135052 3214 16 0 -1182ATOM 1095 C ASP146 13.860 14.441 28.552 1.000 16.65ANISOU 1095 C ASP146 24611904 1961 -128 580 -40ATOM 1096 O ASP146 13.041 14.605 29.457 1.000 15.67ANISOU 1096 O ASP146 21101935 1908 -334 381 -420ATOM 1097 N GLY147 13.871 15.149 27.429 1.000 20.60ANISOU 1097 N GLY147 34842416 1927 -26419 129ATOM 1098 CA GLY147 12.903 16.212 27.155 1.000 18.06ANISOU 1098 CA GLY147 27712451 1638 -382 9893ATOM1099 CGLY 147 13.361 17.57427.6091.000 18.73ANISOU 1099 CGLY 147 28362195 2085 -524 143 527ATOM1100 OGLY 147 12.676 18.57027.2821.000 18.34ANISOU 1100 OGLY 147 28652416 1687 -413 -72 389ATOM1101 NGLY 148 14.498 17.63428.3161.000 16.35ANISOU 1101 NGLY 148 29361506 1772 -157 142 88ATOM1102 CA GLY 148 15.116 18.88928.7471.000 15.34ANISOU 1102 CA GLY 148 27231279 1829 55 450 -26ATOM1103 CGLY 148 14.768 19.33930.1441.000 12.97ANISOU 1103 CGLY 148 22311416 1280 -93-62 407ATOM1104 OGLY 148 13.769 18.93030.7711.000 13.79ANISOU 1104 OGLY 148 23011376 1561 -164 88323ATOM1105 NVAL 149 15.604 20.22430.7181.000 12.81ANISOU 1105 NVAL 149 18151366 1686 155-31 238ATOM1106 CA VAL 149 15.388 20.72432.0791.000 11.81ANISOU 1106 CA VAL 149 13331390 1765 54 -92 129ATOM1107 CB VAL 149 16.594 21.63632.4801.000 11.97ANISOU 1107 CB VAL 149 11361696 1717 -100 246 124ATOM1108 CG1 VAL 149 16.358 22.33633.8021.000 15.26ANISOU 1108 CG1 VAL 149 19411922 1936 -195 55-223ATOM1109 CG2 VAL 149 17.868 20.79432.5381.000 17.21ANISOU 1109 CG2 VAL 149 12312045 3265 45 102 -103ATOM1110 CVAL 149 14.101 21.48232.2801.000 11.32ANISOU 1110 CVAL 149 11861303 1813 -78131 479ATOM1111 OVAL 149 13.378 21.21833.2531.000 12.35ANISOU 1111 OVAL 149 16641423 1608 -71229 167ATOM1112 NGLU 150 13.752 22.46331.4601.000 11.96ANISOU 1112 NGLU 150 13471453 1746 29 -36 420ATOM1113 CA GLU 150 12.592 23.28631.8151.000 10.90ANISOU 1113 CA GLU 150 16231359 1159 1180 405ATOM1114 CB GLU 150 12.608 24.60130.9991.000 17.60ANISOU 1114 CB GLU 150 25301470 2687 181-161 907ATOM1115 CG GLU 150 13.811 25.48831.3141.000 17.86ANISOU 1115 CG GLU 150 2744797 3246 246434 202ATOM1116 CD GLU 150 13.956 25.92932.7381.000 19.47ANISOU 1116 CD GLU 150 30181353 3027 -97-84 662ATOM1117 OE1 GLU 150 12.951 26.00533.4751.000 18.21ANISOU 1117 OE1 GLU 150 30351512 2373 -178 -321 536ATOM1118 OE2 GLU 150 15.109 26.23733.1221.000 22.59ANISOU 1118 OE2 GLU 150 29931664 3927 -38-150 284ATOM1119 CGLU 150 11.277 22.53331.7051.000 12.22ANISOU 1119 CGLU 150 14291540 1676 235147 -5ATOM1120 OGLU 150 10.341 22.75732.5301.000 13.44ANISOU 1120 OGLU 150 17391474 1894 315470 288ATOM1121 NALA 151 11.118 21.62530.7421.000 11.88ANISOU 1121 NALA 151 17831255 1477 94 45253ATOM1122 CA ALA 151 9.881 20.84430.6981.000 13.82ANISOU 1122 CA ALA 151 17442054 1454 -100 -413 396ATOM1123 CB ALA 151 9.739 20.09429.3901.000 14.89ANISOU 1123 CB ALA 151 14892318 1851 22 -269 -35ATOM1124 CALA 151 9.792 19.86431.8671.000 12.71ANISOU 1124 CALA 151 14481463 1920 93 41424ATOM1125 OALA 151 8.655 19.58032.2801.000 14.69ANISOU 1125 OALA 151 15352114 1932 -242 204 -108ATOM1126 NPHE 152 10.925 19.40132.4101.000 11.73ANISOU 1126 NPHE 152 15981259 1598 1209 271ATOM1127 CA PHE 152 10.890 18.55433.6021.000 10.61ANISOU 1127 CA PHE 152 14441061 1526 -3334160ATOM1128 CB PHE 152 12.293 17.98133.8201.000 10.23ANISOU 1128 CB PHE 152 13171132 1437 -144 207 410ATOM1129 CG PHE 152 12.517 17.18735.0951.000 10.36ANISOU 1129 CG PHE 152 138811491399 -34147 276ATOM 1130 CD1 PHE 152 12.036 15.896 35.229 1.000 11.24ANISOU 1130 CD1 PHE 152 147910471743 114-103 566ATOM 1131 CD2 PHE 152 13.229 17.701 36.154 1.000 11.21ANISOU 1131 CD2 PHE 152 148914491319 85 174 151ATOM 1132 CE1 PHE 152 12.252 15.163 36.380 1.000 10.80ANISOU 1132 CE1 PHE 152 140012341467 249-111 373ATOM 1133 CE2 PHE 152 13.431 16.992 37.341 1.000 11.82ANISOU 1133 CE2 PHE 152 170916221160 -276 414 250ATOM 1134 CZ PHE 152 12.932 15.717 37.457 1.000 11.97ANISOU 1134 CZ PHE 152 165116041293 -255 296 170ATOM 1135 C PHE 152 10.430 19.292 34.858 1.000 12.24ANISOU 1135 C PHE 152 175411681730 -10339 84ATOM 1136 O PHE 152 9.728 18.729 35.726 1.000 11.49ANISOU 1136 O PHE 152 167211421550 200109 277ATOM 1137 N LEU 153 10.809 20.575 34.997 1.000 11.85ANISOU 1137 N LEU 153 203012361240 -6 73156ATOM 1138 CA LEU 153 10.532 21.386 36.155 1.000 11.99ANISOU 1138 CA LEU 153 189012291437 -165 307 85ATOM 1139 CB LEU 153 11.654 22.420 36.353 1.000 12.81ANISOU 1139 CB LEU 153 169113811794 -7297-40ATOM 1140 CG LEU 153 13.059 21.910 36.592 1.000 12.87ANISOU 1140 CG LEU 153 176216451483 146269 64ATOM 1141 CD1 LEU 153 14.027 23.081 36.611 1.000 15.99ANISOU 1141 CD1 LEU 153 160920062462 -49450 -431ATOM 1142 CD2 LEU 153 13.185 21.158 37.914 1.000 19.37ANISOU 1142 CD2 LEU 153 309124621806 809275 540ATOM 1143 C LEU 153 9.179 22.084 36.123 1.000 12.96ANISOU 1143 C LEU 153 172812531943 -336 360 -43ATOM 1144 O LEU 153 8.709 22.506 37.193 1.000 13.24ANISOU 1144 O LEU 153 161713022109 -443 481 -182ATOM 1145 N ASP 154 8.568 22.203 34.955 1.000 13.29ANISOU 1145 N ASP 154 164314571951 60 517 280ATOM 1146 CA ASP 154 7.195 22.671 34.764 1.000 14.21ANISOU 1146 CA ASP 154 186212552280 313631 683ATOM 1147 CB ASP 154 6.995 23.269 33.373 1.000 18.38ANISOU 1147 CB ASP 154 209121562738 328728 1475ATOM 1148 CG ASP 154 5.534 23.367 32.929 1.000 22.95ANISOU 1148 CG ASP 154 232335432855 676430 1501ATOM 1149 OD1 ASP 154 4.685 23.607 33.820 1.000 20.85ANISOU 1149 OD1 ASP 154 216423683389 895478 1144ATOM 1150 OD2 ASP 154 5.168 23.254 31.702 1.000 24.33ANISOU 1150 OD2 ASP 154 298931463110 228481128ATOM 1151 C ASP 154 6.294 21.455 34.985 1.000 11.22ANISOU 1151 C ASP 154 159414031265 123147 410ATOM 1152 O ASP 154 6.043 20.729 34.015 1.000 13.31ANISOU 1152 O ASP 154 214317281186 427219 170ATOM 1153 N CYS 155 5.891 21.220 36.233 1.000 9.91ANISOU 1153 N CYS 155 142510981243 -76186 27ATOM 1154 CA CYS 155 5.446 19.881 36.627 1.000 9.41ANISOU 1154 CA CYS 155 129411681115 -13154 172ATOM 1155 CB CYS 155 6.635 19.171 37.269 1.000 10.64ANISOU 1155 CB CYS 155 127610151753 28 -51 -122ATOM 1156 SG CYS 155 7.316 19.819 38.797 1.000 12.01ANISOU 1156 SG CYS 155 137615541633 -195 -199 95ATOM 1157 C CYS 155 4.138 19.885 37.423 1.000 9.66ANISOU 1157 C CYS 155 130113551013 115146 216ATOM 1158 O CYS 155 3.215 20.645 37.064 1.000 11.61ANISOU 1158 O CYS 155 134913861676 130116 294ATOM 1159 N GLU 156 4.021 19.033 38.442 1.000 10.26ANISOU 1159 N GLU 156 126314951139 -29168 299ATOM1160 CAGLU156 2.778 18.78739.1731.000 9.04ANISOU 1160 CAGLU156 998 1160 1278 -76-37 236ATOM1161 CBGLU156 2.300 17.39138.7721.000 11.63ANISOU 1161 CBGLU156 11871348 1885 -67-135 -190ATOM1162 CGGLU156 1.841 17.28237.3261.000 14.29ANISOU 1162 CGGLU156 17411640 2049 -628 -507 50ATOM1163 CDGLU156 0.502 17.94937.0391.000 17.90ANISOU 1163 CDGLU156 17722692 2336 -365 -686 137ATOM1164 OE1 GLU156 -0.220 18.24138.0241.000 19.17ANISOU 1164 OE1 GLU156 14292973 2884 -632 -270 253ATOM1165 OE2 GLU156 0.136 18.19835.8581.000 22.03ANISOU 1165 OE2 GLU156 24493269 2653 -243 -721 924ATOM1166 C GLU156 2.961 18.94240.6771.000 9.21ANISOU 1166 C GLU156 11661135 1197 -26239 183ATOM1167 O GLU156 2.828 17.99741.4761.000 11.22ANISOU 1167 O GLU156 16311199 1434 103162 431ATOM1168 N PRO157 3.337 20.15841.1181.000 10.29ANISOU 1168 N PRO157 13291201 1381 -109 21123ATOM1169 CDPRO157 3.527 21.40740.3591.000 10.17ANISOU 1169 CDPRO157 13811093 1391 -40-30 21ATOM1170 CAPRO157 3.618 20.36342.5531.000 10.28ANISOU 1170 CAPRO157 11601354 1391 -12-61 64ATOM1171 CBPRO157 4.173 21.80542.5901.000 12.44ANISOU 1171 CBPRO157 18321567 1330 -397 2058ATOM1172 CGPRO157 3.475 22.47141.4291.000 10.44ANISOU 1172 CGPRO157 14691259 1237 -388 166 -15ATOM1173 C PRO157 2.387 20.26943.4501.000 10.83ANISOU 1173 C PRO157 12061554 1357 -89-61 76ATOM1174 O PRO157 1.247 20.42242.9921.000 11.38ANISOU 1174 O PRO157 11571742 1426 -93-64 33ATOM1175 N LEU158 2.561 19.98844.7421.000 9.91ANISOU 1175 N LEU158 10111308 1447 -86-53 151ATOM1176 CALEU158 1.524 19.94045.7641.000 10.85ANISOU 1176 CALEU158 13191461 1344 -387 -2-3ATOM1177 CBLEU158 1.152 18.48246.0781.000 11.03ANISOU 1177 CBLEU158 12801447 1464 -251 9993ATOM1178 CGLEU158 0.111 18.23947.1551.000 12.01ANISOU 1178 CGLEU158 12711497 1795 -303 241 128ATOM1179 CD1 LEU158 -1.212 18.82646.7361.000 16.21ANISOU 1179 CD1 LEU158 12242249 2685 -111 41-239ATOM1180 CD2 LEU158 -0.086 16.73647.3971.000 17.17ANISOU 1180 CD2 LEU158 26561542 2325 -254 1273 174ATOM1181 C LEU158 1.997 20.62647.0481.000 11.22ANISOU 1181 C LEU158 14961366 1402 110-304 5ATOM1182 O LEU158 3.056 20.20147.5391.000 11.28ANISOU 1182 O LEU158 12831368 1635 20 -262 75ATOM1183 N LEU159 1.234 21.59947.5481.000 10.86ANISOU 1183 N LEU159 11031744 1278 68 -180 -70ATOM1184 CALEU159 1.540 22.27848.7971.000 11.62ANISOU 1184 CALEU159 12471761 1407 -59-68 -180ATOM1185 CBLEU159 1.494 23.80248.6401.000 12.44ANISOU 1185 CBLEU159 16241747 1354 -209 -73 -33ATOM1186 CGLEU159 1.633 24.63549.9341.000 12.83ANISOU 1186 CGLEU159 16001698 1576 246-54 -215ATOM1187 CD1 LEU159 2.947 24.43550.6511.000 14.28ANISOU 1187 CD1 LEU159 20192250 1158 177-292 104ATOM1188 CD2 LEU159 1.442 26.13449.6401.000 13.33ANISOU 1188 CD2 LEU159 18021721 1543 87 -87 -20ATOM1189 C LEU159 0.537 21.84649.8681.000 11.24ANISOU 1189 C LEU159 13931474 1404 -174 -9-271ATOM1190 O LEU159 -0.665 21.94049.6201.000 13.70ANISOU 1190 O LEU 159 13542395 1457 -328 34-269ATOM 1191 N ARG 160 1.013 21.385 51.010 1.000 14.59ANISOU 1191 N ARG 160 17372569 1239 -390 -128 -224ATOM 1192 CA ARG 160 0.158 21.030 52.153 1.000 13.94ANISOU 1192 CA ARG 160 12652631 1402 157 -137 92ATOM 1193 CB ARG 160 0.161 19.528 52.343 1.000 18.20ANISOU 1193 CB ARG 160 19322645 2338 -301 32193ATOM 1194 CG ARG 160 -0.423 18.661 51.252 1.000 25.12ANISOU 1194 CG ARG 160 34512902 3191 -653 -787 23ATOM 1195 CD ARG 160 -0.765 17.301 51.831 1.000 31.98ANISOU 1195 CD ARG 160 48253598 3729 -1994 -905 321ATOM 1196 NE ARG 160 -1.284 16.322 50.896 1.000 26.15ANISOU 1196 NE ARG 160 33922957 3587 -739 -1056 310ATOM 1197 CZ ARG 160 -0.970 15.044 50.779 1.000 25.30ANISOU 1197 CZ ARG 160 31953390 3028 94-785 295ATOM 1198 NH1 ARG 160 -0.063 14.433 51.552 1.000 31.26ANISOU 1198 NH1 ARG 160 36544142 4080 -629 -1089 2054ATOM 1199 NH2 ARG 160 -1.572 14.308 49.850 1.000 28.82ANISOU 1199 NH2 ARG 160 40203122 3803 -13 -966 -90ATOM 1200 C ARG 160 0.649 21.669 53.447 1.000 15.12ANISOU 1200 C ARG 160 16492863 1232 104 -66 125ATOM 1201 O ARG 160 1.804 21.556 53.863 1.000 17.09ANISOU 1201 O ARG 160 12913411 1791 -400 74-812ATOM 1202 N PHE 161 -0.258 22.369 54.114 1.000 14.95ANISOU 1202 N PHE 161 15122506 1660 -253 -8-146ATOM 1203 CA PHE 161 -0.036 22.949 55.427 1.000 13.27ANISOU 1203 CA PHE 161 16001681 1760 -9 -249 -41ATOM 1204 CB PHE 161 -0.587 24.381 55.472 1.000 16.82ANISOU 1204 CB PHE 161 15941947 2851 384 5864ATOM 1205 CG PHE 161 -0.317 25.109 56.771 1.000 22.56ANISOU 1205 CG PHE 161 24642424 3684 -39 790 -1067ATOM 1206 CD1 PHE 161 -1.175 25.010 57.849 1.000 26.03ANISOU 1206 CD1 PHE 161 33532919 3620 267 1106 -702ATOM 1207 CD2 PHE 161 0.822 25.901 56.885 1.000 25.34ANISOU 1207 CD2 PHE 161 23533265 4011 -179 -161 -738ATOM 1208 CE1 PHE 161 -0.943 25.660 59.051 1.000 30.50ANISOU 1208 CE1 PHE 161 47843324 3481 -972 1456 -620ATOM 1209 CE2 PHE 161 1.061 26.553 58.080 1.000 26.10ANISOU 1209 CE2 PHE 161 25463067 4302 -129 281 -1127ATOM 1210 CZ PHE 161 0.199 26.438 59.164 1.000 30.06ANISOU 1210 CZ PHE 161 38393197 4386 -152 774 -677ATOM 1211 C PHE 161 -0.737 22.073 56.447 1.000 13.93ANISOU 1211 C PHE 161 18421946 1503 -334 -277 -240ATOM 1212 O PHE 161 -1.916 21.843 56.270 1.000 18.26ANISOU 1212 O PHE 161 20003277 1662 -744 -399 475ATOM 1213 N ARG 162 -0.090 21.631 57.503 1.000 16.29ANISOU 1213 N ARG 162 20632516 1610 -937 -523 77ATOM 1214 CA ARG 162 -0.635 20.719 58.483 1.000 15.62ANISOU 1214 CA ARG 162 17722512 1650 -519 -266 76ATOM 1215 C ARG 162 -0.476 21.312 59.890 1.000 17.48ANISOU 1215 C ARG 162 18553131 1656 -603 -186 -76ATOM 1216 O ARG 162 0.609 21.734 60.251 1.000 17.23ANISOU 1216 O ARG 162 19283063 1557 -771 -42 -160ATOM 1217 CB ARG 162 0.081 19.374 58.458 1.000 21.99ANISOU 1217 CB ARG 162 33092318 2727 -272 -737 -22ATOM 1218 CG ARG 162 -0.573 18.322 59.348 1.000 26.07ANISOU 1218 CG ARG 162 34882375 4041 489 655 280ATOM 1219 CD ARG 162 -0.231 16.896 58.886 1.000 25.85ANISOU 1219 CD ARG 162 31062221 4495 418 -2239ATOM 1220 NE ARG 162 -0.943 15.916 59.698 1.000 28.83ANISOU 1220 NE ARG 162 43792437 4139 -181 332 -177ATOM 1221 CZ ARG 162 -0.642 14.638 59.879 1.000 27.99ANISOU 1221 CZ ARG 162 42712497 3868 -179 962 84ATOM 1222 NH1 ARG 162 0.429 14.119 59.273 1.000 26.61ANISOU 1222 NH1 ARG 162 32003167 3742 -91 -126 -268ATOM 1223 NH2 ARG 162 -1.408 13.883 60.658 1.000 34.20ANISOU 1223 NH2 ARG 162 38073522 5663 -986 702 780ATOM 1224 N TYR 163 -1.570 21.296 60.622 1.000 16.77ANISOU 1224 N TYR 163 18032865 1705 -484 -194 84ATOM 1225 CA TYR 163 -1.627 21.749 61.997 1.000 16.73ANISOU 1225 CA TYR 163 18192770 1766 -692 -51 40ATOM 1226 CB TYR 163 -2.712 22.804 62.116 1.000 18.99ANISOU 1226 CB TYR 163 24792560 2175 -427 -303 -214ATOM 1227 CG TYR 163 -3.173 23.206 63.488 1.000 23.52ANISOU 1227 CG TYR 163 25733821 2544 -16 -335 -868ATOM 1228 CD1 TYR 163 -2.316 23.848 64.367 1.000 31.80ANISOU 1228 CD1 TYR 163 36135005 3466 -1151 304 -2338ATOM 1229 CE1 TYR 163 -2.731 24.222 65.625 1.000 40.74ANISOU 1229 CE1 TYR 163 58555676 3950 -1906 976 -3116ATOM 1230 CD2 TYR 163 -4.459 22.965 63.931 1.000 32.55ANISOU 1230 CD2 TYR 163 33075654 3408 -1066 639 -2340ATOM 1231 CE2 TYR 163 -4.902 23.332 65.189 1.000 42.99ANISOU 1231 CE2 TYR 163 56266630 4080 -2352 1989 -2949ATOM 1232 CZ TYR 163 -4.017 23.960 66.025 1.000 42.52ANISOU 1232 CZ TYR 163 62815799 4075 -1721 1943 -3714ATOM 1233 OH TYR 163 -4.380 24.351 67.274 1.000 48.87ANISOU 1233 OH TYR 163 81676831 3569 -269 1801 -3052ATOM 1234 C TYR 163 -1.935 20.551 62.896 1.000 17.90ANISOU 1234 C TYR 163 28722353 1575 -894 -465 -173ATOM 1235 O TYR 163 -2.933 19.858 62.653 1.000 18.12ANISOU 1235 O TYR 163 26942130 2060 -732 -615 67ATOM 1236 N PHE 164 -1.112 20.326 63.898 1.000 18.32ANISOU 1236 N PHE 164 25162621 1826 -614 -402 -90ATOM 1237 CA PHE 164 -1.340 19.381 64.984 1.000 23.44ANISOU 1237 CA PHE 164 41762692 2038 -727 -669 219ATOM 1238 CB PHE 164 -0.073 18.617 65.327 1.000 26.02ANISOU 1238 CB PHE 164 45942824 2470 -459 -822 379ATOM 1239 CG PHE 164 0.407 17.669 64.231 1.000 29.00ANISOU 1239 CG PHE 164 41183639 3263 -518 -427 -254ATOM 1240 CD1 PHE 164 1.224 18.118 63.205 1.000 27.11ANISOU 1240 CD1 PHE 164 30404013 3249 -198 -821 4ATOM 1241 CD2 PHE 164 0.051 16.332 64.240 1.000 28.37ANISOU 1241 CD2 PHE 164 39353139 3704 472 30-64ATOM 1242 CE1 PHE 164 1.657 17.248 62.223 1.000 28.13ANISOU 1242 CE1 PHE 164 27303926 4034 -43 -229 6ATOM 1243 CE2 PHE 164 0.459 15.464 63.250 1.000 31.71ANISOU 1243 CE2 PHE 164 47193694 3635 -293 657 -383ATOM 1244 CZ PHE 164 1.276 15.924 62.234 1.000 30.26ANISOU 1244 CZ PHE 164 38273808 3862 0 300 126ATOM 1245 C PHE 164 -1.775 20.160 66.228 1.000 24.65ANISOU 1245 C PHE 164 35414049 1777 -1025 -455 37ATOM 1246 O PHE 164 -0.889 20.713 66.885 1.000 25.54ANISOU 1246 O PHE 164 35204167 2019 -921 -440 -257ATOM 1247 N PRO 165 -3.058 20.293 66.527 1.000 32.24ANISOU 1247 N PRO 165 36415095 3513 -1894 266 -680ATOM 1248 CA PRO 165 -3.486 21.012 67.720 1.000 32.98ANISOU 1248 CA PRO 165 35705737 3225 -1271 397 -322ATOM 1249 C PRO 165 -2.854 20.429 68.986 1.000 38.48ANISOU 1249 C PRO 165 43556808 3457 -1872 40343ATOM 1250 O PRO 165 -2.551 19.230 69.034 1.000 53.87ANISOU 1250 O PRO 165 99487012 3507 -959 692 1750ATOM 1251 CB PRO 165 -5.001 20.820 67.769 1.000 37.76ANISOU 1251 CB PRO165 3640 6479 4227 -1488 380 -717ATOM1252 CG PRO165 -5.41720.048 66.5691.000 36.16ANISOU 1252 CG PRO165 3341 6449 3948 -518 -349 -398ATOM1253 CD PRO165 -4.19719.816 65.7341.000 35.70ANISOU 1253 CD PRO165 3440 6296 3828 -1656 -5-604ATOM1254 N LEU178 4.459 8.08766.9871.000 36.23ANISOU 1254 N LEU178 4509 3338 5918 -261216 1175ATOM1255 CA LEU178 4.994 9.11766.1161.000 28.63ANISOU 1255 CA LEU178 3397 3170 4312 3771344 401ATOM1256 CB LEU178 5.882 8.53465.0271.000 30.08ANISOU 1256 CB LEU178 3497 3245 4688 760752 -620ATOM1257 CG LEU178 7.245 7.94865.3481.000 29.43ANISOU 1257 CG LEU178 3557 2950 4674 667371 -979ATOM1258 CD1LEU178 7.859 7.36764.0731.000 32.13ANISOU 1258 CD1LEU178 2972 4524 4713 586810 -790ATOM1259 CD2LEU178 8.208 8.96465.9371.000 41.71ANISOU 1259 CD2LEU178 5303 3695 6850 356-1656 -1154ATOM1260 C LEU178 3.885 9.90965.4201.000 27.18ANISOU 1260 C LEU178 2107 3534 4686 -175 1776 833ATOM1261 O LEU178 2.845 9.35165.0861.000 39.60ANISOU 1261 O LEU178 2407 4624 8016 -1253 1290 2183ATOM1262 N ARG179 4.128 11.200 65.1601.000 25.65ANISOU 1262 N ARG179 2220 3437 4089 -216 878 741ATOM1263 CA ARG179 3.231 11.973 64.3211.000 25.04ANISOU 1263 CA ARG179 1860 3289 4365 69 641 15ATOM1264 C ARG179 3.297 11.572 62.8521.000 24.51ANISOU 1264 C ARG179 2158 2721 4434 39 99-89ATOM1265 O ARG179 2.295 11.687 62.1391.000 28.60ANISOU 1265 O ARG179 2545 3242 5079 441-332 -256ATOM1266 CB ARG179 3.517 13.480 64.4511.000 28.58ANISOU 1266 CB ARG179 3980 3317 3561 -110 -843 57ATOM1267 CG ARG179 2.936 14.092 65.7241.000 30.01ANISOU 1267 CG ARG179 3817 3725 3862 57 -957 -372ATOM1268 CD ARG179 3.307 15.570 65.7571.000 31.51ANISOU 1268 CD ARG179 4457 3675 3840 90 -1514 -338ATOM1269 NE ARG179 2.925 16.126 67.0581.000 37.82ANISOU 1269 NE ARG179 7035 3190 4144 153-310 -15ATOM1270 CZ ARG179 2.897 17.425 67.2921.000 39.43ANISOU 1270 CZ ARG179 8420 3029 3532 -479 580 400ATOM1271 NH1ARG179 3.213 18.286 66.3311.000 59.73ANISOU 1271 NH1ARG179 11745 4676 6273 -1045 3177 1722ATOM1272 NH2ARG179 2.548 17.896 68.4571.000 33.13ANISOU 1272 NH2ARG179 5661 3832 3094 275-1463 -173ATOM1273 N MET180 4.455 11.099 62.4241.000 21.43ANISOU 1273 N MET180 2013 2457 3674 -395 108 -222ATOM1274 CA MET180 4.695 10.539 61.1081.000 20.07ANISOU 1274 CA MET180 2346 1965 3315 -349 -300 151ATOM1275 C MET180 5.802 9.48261.1821.000 17.33ANISOU 1275 C MET180 2251 2080 2254 -332 -86 337ATOM1276 O MET180 6.894 9.75761.6771.000 18.52ANISOU 1276 O MET180 2237 2019 2781 -398 -79 52ATOM1277 CB MET180 5.041 11.646 60.1361.000 22.64ANISOU 1277 CB MET180 2571 2321 3709 -197 -549 683ATOM1278 CG MET180 5.065 11.367 58.6781.000 27.90ANISOU 1278 CG MET180 3918 3095 3588 -453 -654 913ATOM1279 SD MET180 4.945 12.838 57.6291.000 25.01ANISOU 1279 SD MET180 2936 2942 3626 -399 124 851ATOM1280 CE MET180 4.385 12.010 56.1471.000 37.00ANISOU 1280 CE MET180 5917 3450 4690 -258 -2680 1204ATOM1281 N ALA181 5.467 8.29560.6801.000 16.99ANISOU 1281 N ALA181 2144 2139 2174 -90-558 299ATOM 1282 CA ALA 181 6.396 7.168 60.676 1.000 16.12ANISOU 1282 CA ALA 181 22751958 1890 -171 -343 602ATOM 1283 CB ALA 181 5.668 5.891 60.279 1.000 20.24ANISOU 1283 CB ALA 181 28572158 2673 -648 694 106ATOM 1284 C ALA 181 7.576 7.409 59.738 1.000 15.43ANISOU 1284 C ALA 181 22231717 1925 -315 -369 432ATOM 1285 O ALA 181 7.458 8.198 58.783 1.000 15.49ANISOU 1285 O ALA 181 22681761 1858 -173 -296 434ATOM 1286 N PRO 182 8.698 6.733 59.986 1.000 16.03ANISOU 1286 N PRO 182 25171745 1829 32 -78 531ATOM 1287 CD PRO 182 8.983 5.802 61.101 1.000 19.61ANISOU 1287 CD PRO 182 23212908 2221 -210 -306 1240ATOM 1288 CA PRO 182 9.865 6.907 59.076 1.000 14.78ANISOU 1288 CA PRO 182 25731336 1706 -101 -86 299ATOM 1289 CB PRO 182 10.914 5.948 59.649 1.000 16.20ANISOU 1289 CB PRO 182 25701978 1607 170-251 77ATOM 1290 CG PRO 182 10.479 5.713 61.066 1.000 19.28ANISOU 1290 CG PRO 182 23013071 1952 -199 -245 1001ATOM 1291 C PRO 182 9.541 6.571 57.627 1.000 14.90ANISOU 1291 C PRO 182 22301658 1772 -421 -262 340ATOM 1292 O PRO 182 8.920 5.573 57.249 1.000 15.38ANISOU 1292 O PRO 182 23011587 1957 -467 -482 539ATOM 1293 N HIS 183 9.969 7.460 56.730 1.000 12.28ANISOU 1293 N HIS 183 17371312 1617 -154 -284 156ATOM 1294 CA HIS 183 9.733 7.354 55.300 1.000 11.90ANISOU 1294 CA HIS 183 14131495 1614 -254 -351 35ATOM 1295 CB HIS 183 8.300 7.824 54.922 1.000 12.43ANISOU 1295 CB HIS 183 13991368 1957 -128 -241 112ATOM 1296 CG HIS 183 8.168 9.314 55.089 1.000 11.36ANISOU 1296 CG HIS 183 13491369 1600 -367 -296 56ATOM 1297 CD2 HIS 183 8.259 10.374 54.249 1.000 12.03ANISOU 1297 CD2 HIS 183 16841296 1589 -43157 -10ATOM 1298 ND1 HIS 183 7.989 9.858 56.339 1.000 13.27ANISOU 1298 ND1 HIS 183 19011439 1700 -65267 193ATOM 1299 CE1 HIS 183 7.943 11.187 56.244 1.000 12.43ANISOU 1299 CE1 HIS 183 19391490 1296 77 -244 150ATOM 1300 NE2 HIS 183 8.101 11.515 54.992 1.000 11.04ANISOU 1300 NE2 HIS 183 15601437 1199 215-232 48ATOM 1301 C HIS 183 10.749 8.176 54.515 1.000 12.27ANISOU 1301 C HIS 183 14461639 1577 -303 -282 -67ATOM 1302 O HIS 183 11.433 9.032 55.064 1.000 12.94ANISOU 1302 O HIS 183 14961915 1505 -558 -292 15ATOM 1303 N TYR 184 10.849 7.907 53.215 1.000 10.61ANISOU 1303 N TYR 184 14531027 1552 -41-380 110ATOM 1304 CA TYR 184 11.483 8.800 52.256 1.000 11.36ANISOU 1304 CA TYR 184 14751104 1738 -71-264 178ATOM 1305 CB TYR 184 12.628 8.151 51.481 1.000 11.79ANISOU 1305 CB TYR 184 16311114 1734 -62-197 34ATOM 1306 CG TYR 184 12.368 6.907 50.677 1.000 11.29ANISOU 1306 CG TYR 184 16809211688 225-893 174ATOM 1307 CD1 TYR 184 12.156 5.659 51.268 1.000 11.76ANISOU 1307 CD1 TYR 184 16639271879 388-487 190ATOM 1308 CE1 TYR 184 11.911 4.526 50.492 1.000 12.64ANISOU 1308 CE1 TYR 184 19608781964 173-40 182ATOM 1309 CD2 TYR 184 12.333 6.949 49.279 1.000 11.13ANISOU 1309 CD2 TYR 184 12521302 1674 109-283 93ATOM 1310 CE2 TYR 184 12.102 5.834 48.502 1.000 12.93ANISOU 1310 CE2 TYR 184 19441422 1546 49 -384 73ATOM 1311 CZ TYR 184 11.898 4.611 49.121 1.000 13.14ANISOU 1311 CZ TYR 184 17171304 1972 30 -611 67ATOM 1312 OH TYR 184 11.663 3.490 48.343 1.000 15.45ANISOU 1312 OH TYR184 202814712373 42 -476 -247ATOM1313 C TYR184 10.447 9.390 51.3141.000 11.50ANISOU 1313 C TYR184 144512151709 -187 -201 348ATOM1314 O TYR184 9.362 8.797 51.0891.000 11.75ANISOU 1314 O TYR184 130513081853 -106 -171 427ATOM1315 N ASP185 10.784 10.557 50.7431.000 10.79ANISOU 1315 N ASP185 158110691449 -141 -132 118ATOM1316 CA ASP185 9.861 11.218 49.8151.000 9.10ANISOU 1316 CA ASP185 108910931277 -326 23206ATOM1317 CB ASP185 9.934 12.743 49.8861.000 10.13ANISOU 1317 CB ASP185 142710951327 -298 -178 177ATOM1318 CG ASP185 9.540 13.388 51.1851.000 11.79ANISOU 1318 CG ASP185 179713501333 -250 -149 11ATOM1319 OD1ASP185 9.681 14.638 51.2781.000 13.79ANISOU 1319 OD1ASP185 205013161875 135-52 -26ATOM1320 OD2ASP185 9.114 12.755 52.1891.000 13.31ANISOU 1320 OD2ASP185 180518481405 -411 -63 105ATOM1321 C ASP185 10.098 10.759 48.3711．000 9.44ANISOU 1321 C ASP185 103611501401 -309 -26 100ATOM1322 O ASP185 11.234 10.469 48.0051.000 10.64ANISOU 1322 O ASP185 116713761500 -127 -35 -206ATOM1323 N LEU186 9.038 10.684 47.5681.000 10.09ANISOU 1323 N LEU186 121111861437 -272 -177 -58ATOM1324 CA LEU186 9.124 10.312 46.1611.000 10.60ANISOU 1324 CA LEU186 1641986 1401 -239 -52 -44ATOM1325 CB LEU186 8.030 9.295 45.7981.000 11.32ANISOU 1325 CB LEU186 1652929 1721 -111 17-479ATOM1326 CG LEU186 7.989 7.977 46.6021.000 12.60ANIS0U 1326 CG LEU186 140810392340 -263 -200 -166ATOM1327 CD1LEU186 6.896 7.064 46.0281.000 16.64ANISOU 1327 CD1LEU186 190013733049 -634 -398 -135ATOM1328 CD2LEU186 9.356 7.332 46.6291.000 13.84ANISOU 1328 CD2LEU186 143812452575 -155 443 283ATOM1329 C LEU186 9.024 11.521 45.2231.000 10.90ANISOU 1329 C LEU186 132712111603 -3 -451 164ATOM1330 O LEU186 8.768 11.406 44.0311.000 13.60ANISOU 1330 O LEU186 206716081494 -211 -321 103ATOM1331 N SER187 9.264 12.705 45.7341.000 10.71ANISOU 1331 N SER187 154611291393 -76-282 318ATOM1332 CA SER187 9.401 13.943 44.9981.000 10.49ANISOU 1332 CA SER187 142711911370 195-107 488ATOM1333 CB SER187 9.221 15.103 46.0021.000 10.56ANISOU 1333 CB SER187 110510481857 298161 532ATOM1334 OG SER187 10.430 14.918 46.7261.000 13.01ANISOU 1334 OG SER187 134314322169 -132 -295 201ATOM1335 C SER187 10.774 14.062 44.3361.000 10.47ANISOU 1335 C SER187 1447862 1669 135-3145ATOM1336 O SER187 11.684 13.246 44.5131.000 10.54ANISOU 1336 O SER187 1577799 1629 183-91 -77ATOM1337 N MET188 10.962 15.095 43.5021.000 9.78ANISOU 1337 N MET188 1419978 1318 1474474ATOM1338 CA MET188 12.267 15.584 43.0651.000 9.94ANISOU 1338 CA MET188 1394942 1441 1825837ATOM1339 CB MET188 12.128 16.543 41.8911.000 10.89ANISOU 1339 CB MET188 1523840 1774 98 48227ATOM1340 CG MET188 13.385 17.258 41.4701.000 11.40ANISOU 1340 CG MET188 140311721756 46 -51 214ATOM1341 SD MET188 14.687 16.134 40.8911.000 12.71ANISOU 1341 SD MET188 161912721940 139137 198ATOM1342 CE MET188 16.061 17.267 40.7901.000 13.86ANISOU 1342 CE MET188 186213992003 -2 911 -90ATOM1343 C MET188 12.94616.21744.2911.000 12.13ANISOU 1343 C MET188 1325 1586 1698 169-18 -285ATOM1344 O MET188 13.97115.72744.8041.000 11.52ANISOU 1344 O MET188 1288 1553 1535 144132 87ATOM1345 N VAL189 12.36217.29044.8381.000 10.00ANISOU 1345 N VAL189 1290 1217 1292 53 -175 6ATOM1346 CAVAL189 12.74517.89446.0991.000 9.70ANISOU 1346 CAVAL189 1209 1057 1420 -212 -45 -19ATOM1347 CBVAL189 13.61819.15445.9791.000 9.97ANISOU 1347 CBVAL189 1288 1103 1398 -238 129 189ATOM1348 CG1 VAL189 14.95318.83745.2661.000 13.45ANISOU 1348 CG1 VAL189 1334 1410 2368 -236 390 143ATOM1349 CG2 VAL189 12.89920.28945.2641.000 12.24ANISOU 1349 CG2 VAL189 1715 1242 1693 -25150 295ATOM1350 C VAL189 11.46918.24546.8711.000 10.10ANISOU 1350 C VAL189 1089 1600 1149 -456 -156 -73ATOM1351 O VAL189 10.40518.39946.2501.000 9.53ANISOU 1351 O VAL189 1153 1249 1217 -222 -190 8ATOM1352 N THR190 11.60918.32748.1871.000 8.66ANISOU 1352 N THR190 1273 894 1123 15 -202 127ATOM1353 CATHR190 10.56518.77149.0911.000 9.64ANISOU 1353 CATHR190 1350 1167 1147 -11-228 -99ATOM1354 CBTHR190 10.19417.69950.1321.000 10.69ANISOU 1354 CBTHR190 1231 1196 1635 -300 121 -54ATOM1355 OG1 THR190 9.662 16.58649.5011.000 12.45ANISOU 1355 OG1 THR190 1333 1341 2055 -140 -258 -48ATOM1356 CG2 THR190 9.038 18.13151.0191.000 13.59ANISOU 1356 CG2 THR190 1121 2222 1821 -272 151 -195ATOM1357 C THR190 11.05819.97649.8911.000 9.23ANISOU 1357 C THR190 1257 1096 1152 -102 -336 -49ATOM1358 O THR190 12.14919.86750.4471.000 10.54ANISOU 1358 O THR190 1322 1292 1390 -5 -359 -122ATOM1359 N LEU191 10.31321.06449.9781.000 10.23ANISOU 1359 N LEU191 1319 1167 1401 -71-177 -133ATOM1360 CALEU191 10.69122.24150.7701.000 10.19ANISOU 1360 CALEU191 1259 1176 1438 0 -294 -142ATOM1361 CBLEU191 10.60423.51149.9101.000 11.52ANISOU 1361 CBLEU191 1203 1185 1990 -118 -601 32ATOM1362 CGLEU191 11.89723.89849.1671.000 13.23ANISOU 1362 CGLEU191 1898 1710 1419 -391 -358 97ATOM1363 CD1 LEU191 12.33322.79448.2181.000 15.25ANISOU 1363 CD1 LEU191 1685 2018 2091 -476 -214 -305ATOM1364 CD2 LEU191 11.71725.23148.4481.000 17.46ANISOU 1364 CD2 LEU191 2310 2044 2281 -1417604ATOM1365 C LEU191 9.798 22.32852.0061.000 11.93ANISOU 1365 C LEU191 1275 1677 1579 56 -190 -372ATOM1366 O LEU191 8.560 22.26251.8681.000 13.49ANISOU 1366 O LEU191 1276 2173 1676 1 -192 -601ATOM1367 N ILE192 10.39422.48353.1901.000 11.06ANISOU 1367 N ILE192 1115 1603 1487 -111 -92 -108ATOM1368 CAILE192 9.671 22.53954.4431.000 11.13ANISOU 1368 CAILE192 1071 1638 1521 11 -173 -149ATOM1369 CBILE192 9.927 21.30455.3301.000 12.94ANISOU 1369 CBILE192 2099 1586 1232 -65-9-233ATOM1370 CG2 ILE192 9.221 21.42856.6731.000 16.06ANISOU 1370 CG2 ILE192 2479 1983 1641 -206 426 -215ATOM1371 CG1 ILE192 9.512 20.02854.5901.000 15.51ANISOU 1371 CG1 ILE192 2633 1658 1601 -400 -48 -175ATOM1372 CD1 ILE192 9.845 18.76555.3391.000 25.71ANISOU 1372 CD1 ILE192 5869 1608 2290 -175 -156 -301ATOM1373 C ILE192 9.966 23.80955.2531.000 11.47ANISOU 1373 CILE 192 13301603 1427 -4 -222 -122ATOM1374 OILE 192 11.123 24.10655.5671.000 13.33ANISOU 1374 OILE 192 13441738 1981 -96-289 -219ATOM1375 NGLN 193 8.904 24.52555.6021.000 15.78ANISOU 1375 NGLN 193 13162462 2219 -64-5-975ATOM1376 CA GLN 193 8.987 25.65356.5331.000 14.56ANISOU 1376 CA GLN 193 15821858 2091 212-304 -529ATOM1377 CB GLN 193 8.449 26.97556.0201.000 20.03ANISOU 1377 CB GLN 193 22262203 3180 318-329 142ATOM1378 CG GLN 193 9.203 27.68454.9141.000 23.86ANISOU 1378 CG GLN 193 33992492 3174 31345280ATOM1379 CD GLN 193 8.665 29.07954.6751.000 22.92ANISOU 1379 CD GLN 193 32502363 3097 78 -477 205ATOM1380 OE1 GLN 193 7.603 29.29254.0991.000 27.68ANISOU 1380 OE1 GLN 193 41753310 3031 552-1214 29ATOM1381 NE2 GLN 193 9.411 30.07555.1341.000 27.01ANISOU 1381 NE2 GLN 193 31872667 4408 -440 124 17ATOM1382 CGLN 193 8.216 25.26557.8041.000 15.14ANISOU 1382 CGLN 193 19451827 1982 136-174 -722ATOM1383 OGLN 193 7.147 24.66257.7141.000 27.80ANISOU 1383 OGLN 193 25236225 1817 -1586 -592 235ATOM1384 NGLN 194 8.714 25.55258.9781.000 19.80ANISOU 1384 NGLN 194 29942502 2025 -632 -752 33ATOM1385 CA GLN 194 8.100 25.08060.2131.000 22.89ANISOU 1385 CA GLN 194 39612626 2110 493-20 52ATOM1386 CGLN 194 7.763 26.23661.1411.000 27.79ANISOU 1386 CGLN 194 48862757 2916 82325-262ATOM1387 OGLN 194 8.424 27.25860.9831.000 30.03ANISOU 1387 OGLN 194 47273168 3516 368-259 -910ATOM1388 CB GLN 194 9.086 24.17060.9501.000 23.97ANISOU 1388 CB GLN 194 39523133 2021 846483 352ATOM1389 CG GLN 194 9.398 22.83560.3141.000 21.94ANISOU 1389 CG GLN 194 27403238 2358 683-182 -10ATOM1390 CD GLN 194 10.546 22.14861.0521.000 20.51ANISOU 1390 CD GLN 194 24503433 1911 509-321 -429ATOM1391 OE1 GLN 194 11.707 22.14260.6271.000 20.80ANISOU 1391 OE1 GLN 194 22452996 2662 -171 -382 -681ATOM1392 NE2 GLN 194 10.223 21.58562.1971.000 24.91ANISOU 1392 NE2 GLN 194 25393902 3023 210-365 760ATOM1393 NTHR 195 6.817 26.03562.0301.000 32.47ANISOU 1393 NTHR 195 57162729 3891 1095 1056 -616ATOM1394 CA THR 195 6.588 26.70863.2821.000 35.83ANISOU 1394 CA THR 195 63293539 3748 1011 999 -722ATOM1395 CB THR 195 5.263 27.49263.3571.000 37.96ANISOU 1395 CB THR 195 57564304 4365 6472095 -1151ATOM1396 OG1 THR 195 4.191 26.57663.6041.000 48.36ANISOU 1396 OG1 THR 195 68746076 5423 -806 2581 -1842ATOM1397 CG2 THR 195 4.958 28.17562.0331.000 44.54ANISOU 1397 CG2 THR 195 29447471 6510 -872 -963 621ATOM1398 CTHR 195 6.590 25.68464.4291.000 48.86ANISOU 1398 CTHR 195 10133 4924 3508 -321 -1356 -221ATOM1399 OTHR 195 6.122 24.54464.2931.000 64.12ANISOU 1399 OTHR 195 13267 4150 6945 -264 -4541 1682ATOM1400 NPHE 201 12.035 21.37472.2051.000 71.12ANISOU 1400 NPHE 201 13961 9034 4028 -5932 -1658 -1741ATOM1401 CA PHE 201 11.775 20.05371.6291.000 49.44ANISOU 1401 CA PHE 201 79187542 3326 -3128 1317 -1488ATOM1402 CB PHE 201 10.469 19.46472.1811.000 47.85ANISOU 1402 CB PHE 201 71196892 4168 -1869 1937 -1899ATOM1403 CG PHE 201 10.130 18.11371.5451.000 46.41ANISOU 1403 CG PHE 201 66436596 4396 -2038 1879 -1497ATOM 1404 CD1 PHE 201 10.738 16.95471.9911.000 50.03ANISOU 1404 CD1 PHE 201 79826634 4393 -2326 1092 -991ATOM 1405 CD2 PHE 201 9.220 18.00170.5131.000 42.63ANISOU 1405 CD2 PHE 201 54586427 4313 -1097 2449 -2268ATOM 1406 CE1 PHE 201 10.434 15.73971.4171.000 49.95ANISOU 1406 CE1 PHE 201 82756464 4240 -2047 227 -716ATOM 1407 CE2 PHE 201 8.901 16.78369.9341.000 41.38ANISOU 1407 CE2 PHE 201 60165946 3762 -578 2006 -1844ATOM 1408 CZ PHE 201 9.515 15.63670.3921.000 44.74ANISOU 1408 CZ PHE 201 70756261 3663 -1063 1020 -975ATOM 1409 C PHE 201 11.722 20.11070.1071.000 42.42ANISOU 1409 C PHE 201 63246442 3351 -1964 717 -1441ATOM 1410 O PHE 201 11.007 20.94169.5361.000 47.79ANISOU 1410 0 PHE 201 96684400 4090 -762 691 -2416ATOM 1411 N VAL 202 12.477 19.23269.4491.000 34.04ANISOU 1411 N VAL 202 45255852 2558 -1948 7 -425ATOM 1412 CA VAL 202 12.535 19.24567.9931.000 25.09ANISOU 1412 CA VAL 202 32213752 2558 -1041 -182 99ATOM 1413 CB VAL 202 13.988 19.28667.4891.000 22.88ANISOU 1413 CB VAL 202 28323430 2432 -577 -691 -198ATOM 1414 CG1 VAL 202 14.053 19.38765.9651.000 26.02ANISOU 1414 CG1 VAL 202 38213594 2470 -958 35-277ATOM 1415 CG2 VAL 202 14.771 20.44368.0781.000 24.69ANISOU 1415 CG2 VAL 202 30433473 2867 -786 -410 -320ATOM 1416 C VAL 202 11.798 18.03567.4211.000 20.69ANISOU 1416 C VAL 202 30272810 2023 -648 58615ATOM 1417 O VAL 202 12.288 16.91467.5811.000 26.08ANISOU 1417 O VAL 202 32943219 3396 -136 452 884ATOM 1418 N SER 203 10.662 18.23466.7661.000 20.21ANISOU 1418 N SER 203 31002794 1787 -414 25-152ATOM 1419 CA SER 203 9.820 17.19266.2181.000 20.37ANISOU 1419 CA SER 203 31492709 1884 -355 129 -256ATOM 1420 CB SER 203 8.437 17.77965.8961.000 24.72ANISOU 1420 CB SER 203 27264106 2558 -178 369 -1015ATOM 1421 OG SER 203 7.841 18.23967.0971.000 31.80ANISOU 1421 OG SER 203 33285782 2974 -457 1175 -1104ATOM 1422 C SER 203 10.367 16.52464.9581.000 19.13ANISOU 1422 C SER 203 25802647 2040 -339 170 -244ATOM 1423 O SER 203 10.279 15.30264.8321.000 17.01ANISOU 1423 O SER 203 23112625 1527 -414 206 -18ATOM 1424 N LEU 204 10.902 17.25963.9981.000 16.16ANISOU 1424 N LEU 204 21421976 2024 71 77-292ATOM 1425 CA LEU 204 11.403 16.67962.7401.000 14.07ANISOU 1425 CA LEU 204 16701626 2049 -22-24 -283ATOM 1426 CB LEU 204 11.269 17.70461.6181.000 13.80ANISOU 1426 CB LEU 204 15491763 1931 -249 -340 -277ATOM 1427 CG LEU 204 11.647 17.27260.2121.000 14.13ANISOU 1427 CG LEU 204 17261722 1919 -253 -482 -412ATOM 1428 CD1 LEU 204 10.770 16.13459.6801.000 18.76ANISOU 1428 CD1 LEU 204 25792895 1654 -1297 -927 -106ATOM 1429 CD2 LEU 204 11.609 18.47859.2551.000 16.20ANISOU 1429 CD2 LEU 204 19872095 2074 65 75-123ATOM 1430 C LEU 204 12.832 16.14062.8851.000 14.81ANISOU 1430 C LEU 204 17341748 2144 9 -199 -250ATOM 1431 O LEU 204 13.699 16.85363.3971.000 15.52ANISOU 1431 O LEU 204 18331789 2274 -59-435 -42ATOM 1432 N GLN 205 13.065 14.90062.4691.000 14.42ANISOU 1432 N GLN 205 18471804 1827 189-120 -153ATOM 1433 CA GLN 205 14.288 14.14362.5741.000 12.76ANISOU 1433 CA GLN 205 17771655 1419 43 -347 -113ATOM 1434 C GLN 205 14.622 13.43461.2601.000 11.12ANISOU 1434 CGLN 205 14121474 1338 49 -468 -21ATOM1435 OGLN 205 13.707 12.92760.6061.000 13.97ANISOU 1435 OGLN 205 16222235 1449 -293 -449 -147ATOM1436 CB GLN 205 14.164 13.06263.6621.000 15.57ANISOU 1436 CB GLN 205 24211925 1568 341151 83ATOM1437 CG GLN 205 13.863 13.63565.0321.000 18.58ANISOU 1437 CG GLN 205 33212286 1451 689-129 82ATOM1438 CD GLN 205 15.086 14.24365.6801.000 24.33ANISOU 1438 CD GLN 205 36873465 2091 520-499 -570ATOM1439 OE1 GLN 205 16.206 13.71765.5491.000 29.12ANISOU 1439 OE1 GLN 205 33503464 4251 14 -270 -1800ATOM1440 NE2 GLN 205 14.840 15.35666.3781.000 23.01ANISOU 1440 NE2 GLN 205 30552465 3225 335-592 -140ATOM1441 NALA 206 15.893 13.40160.8931.000 12.63ANISOU 1441 NALA 206 15231770 1506 -251 -234 -6ATOM1442 CA ALA 206 16.335 12.64959.7311.000 13.77ANISOU 1442 CA ALA 206 13922099 1742 -522 -72 -295ATOM1443 CB ALA 206 16.693 13.51958.5281.000 16.34ANISOU 1443 CB ALA 206 20342494 1682 -603 123 -277ATOM1444 CALA 206 17.567 11.81360.0461.000 15.92ANISOU 1444 CALA 206 14892331 2230 -290 179 -341ATOM1445 OALA 206 18.368 12.18260.9081.000 15.86ANISOU 1445 OALA 206 18771772 2377 150-356 30ATOM1446 NGLU 207 17.707 10.71259.3051.000 16.98ANISOU 1446 NGLU 207 19812086 2383 -335 348 -186ATOM1447 CA GLU 207 18.938 9.942 59.3641.000 20.58ANISOU 1447 CA GLU 207 21981938 3684 -164 490 -10ATOM1448 CGLU 207 20.082 10.68858.6811.000 18.75ANISOU 1448 CGLU 207 18282037 3260 272185 558ATOM1449 OGLU 207 19.948 10.95357.5031.000 18.23ANISOU 1449 OGLU 207 17462145 3034 52 8 -45ATOM1450 CB GLU 207 18.665 8.612 58.6761.000 25.81ANISOU 1450 CB GLU 207 32891794 4724 -1983-135ATOM1451 CG GLU 207 19.879 7.737 58.4291.000 30.08ANISOU 1451 CG GLU 207 41022221 5105 907-948 -546ATOM1452 CD GLU 207 19.429 6.356 57.9591.000 29.93ANISOU 1452 CD GLU 207 55492024 3798 1179 -2099 -123ATOM1453 OE1 GLU 207 19.491 5.471 58.8391.000 35.14ANISOU 1453 OE1 GLU 207 57822692 4879 938-931 885ATOM1454 OE2 GLU 207 19.037 6.251 56.7621.000 38.62ANISOU 1454 OE2 GLU 207 49555608 4109 135-2494 -366ATOM1455 NVAL 208 21.146 10.99759.4141.000 16.97ANISOU 1455 NVAL 208 19261974 2549 120337 807ATOM1456 CA VAL 208 22.376 11.59358.9021.000 17.77ANISOU 1456 CA VAL 208 18942109 2748 93 500 411ATOM1457 CB VAL 208 22.455 13.11159.1551.000 16.89ANISOU 1457 CB VAL 208 27742148 1494 -372 -149 569ATOM1458 CG1 VAL 208 23.652 13.68858.4091.000 20.76ANISOU 1458 CG1 VAL 208 32142150 2526 -423 647 148ATOM1459 CG2 VAL 208 21.172 13.81558.7201.000 16.36ANISOU 1459 CG2 VAL 208 31461640 1431 25 98353ATOM1460 CVAL 208 23.585 10.87759.5071.000 20.29ANISOU 1460 CVAL 208 19362555 3217 11 -58 132ATOM1461 OVAL 208 23.726 10.82960.7411.000 20.74ANISOU 1461 OVAL 208 24362256 3187 460206 544ATOM1462 NGLY 209 24.457 10.29558.6721.000 18.94ANISOU 1462 NGLY 209 17642445 2989 211-494 15ATOM1463 CA GLY 209 25.558 9.508 59.1941.000 24.01ANISOU 1463 CA GLY 209 21713040 3910 549-396 709ATOM1464 CGLY 209 25.123 8.364 60.0821.000 25.00ANISOU 1464 CGLY 209 28743156 3470 1406 772 649ATOM 1465 O GLY 209 25.850 7.934 60.991 1.000 35.98ANISOU 1465 O GLY 209 44483946 5279 1425 -426 1769ATOM 1466 N GLY 210 23.951 7.786 59.869 1.000 25.89ANISOU 1466 N GLY 210 38022756 3278 523899 749ATOM 1467 CA GLY 210 23.477 6.678 60.671 1.000 26.43ANISOU 1467 CA GLY 210 44792136 3427 1228 742 912ATOM 1468 C GLY 210 22.885 7.025 62.016 1.000 28.45ANISOU 1468 C GLY 210 54722099 3237 8311029 1175ATOM 1469 O GLY 210 22.634 6.098 62.789 1.000 40.26ANISOU 1469 O GLY 210 73222719 5256 1881 2759 2360ATOM 1470 N ALA 211 22.651 8.281 62.338 1.000 25.78ANISOU 1470 N ALA 211 46712359 2763 1370 724 1197ATOM 1471 CA ALA 211 22.048 8.671 63.613 1.000 23.74ANISOU 1471 CA ALA 211 29663156 2896 727339 663ATOM 1472 CB ALA 211 23.093 9.333 64.496 1.000 29.57ANISOU 1472 CB ALA 211 29574372 3906 834-96 69ATOM 1473 C ALA 211 20.900 9.626 63.360 1.000 21.19ANISOU 1473 C ALA 211 30902611 2350 484178 741ATOM 1474 O ALA 211 20.936 10.381 62.399 1.000 23.91ANISOU 1474 O ALA 211 37712659 2653 -30-66 930ATOM 1475 N PHE 212 19.889 9.629 64.204 1.000 19.88ANISOU 1475 N PHE 212 26032577 2375 398-128 374ATOM 1476 CA PHE 212 18.814 10.613 64.130 1.000 19.13ANISOU 1476 CA PHE 212 25812257 2432 284-565 317ATOM 1477 C PHE 212 19.320 12.006 64.489 1.000 20.00ANISOU 1477 C PHE 212 30042480 2115 133-640 68ATOM 1478 O PHE 212 19.893 12.230 65.569 1.000 21.10ANISOU 1478 O PHE 212 24973558 1964 -391 -406 222ATOM 1479 CB PHE 212 17.688 10.290 65.096 1.000 21.37ANISOU 1479 CB PHE 212 25532616 2952 293-197 -184ATOM 1480 CG PHE 212 17.010 8.950 64.912 1.000 23.45ANISOU 1480 CG PHE 212 21613496 3253 -376 -282 -558ATOM 1481 CD1 PHE 212 16.369 8.377 65.990 1.000 23.33ANISOU 1481 CD1 PHE 212 25453115 3206 -382 -350 -508ATOM 1482 CD2 PHE 212 17.029 8.302 63.687 1.000 25.83ANISOU 1482 CD2 PHE 212 25543962 3299 -622 -217 -787ATOM 1483 CE1 PHE 212 15.730 7.149 65.872 1.000 28.13ANISOU 1483 CE1 PHE 212 37843544 3362 -1119 96-973ATOM 1484 CE2 PHE 212 16.419 7.072 63.569 1.000 23.04ANISOU 1484 CE2 PHE 212 25042960 3289 382-232 -558ATOM 1485 CZ PHE 212 15.781 6.486 64.651 1.000 27.88ANISOU 1485 CZ PHE 212 36583977 2957 -1072 -501 -760ATOM 1486 N THR 213 19.076 12.936 63.578 1.000 18.30ANISOU 1486 N THR 213 26902083 2181 149-583 -93ATOM 1487 CA THR 213 19.566 14.310 63.681 1.000 17.99ANISOU 1487 CA THR 213 19762139 2721 230-686 -287ATOM 1488 CB THR 213 20.515 14.586 62.498 1.000 20.43ANISOU 1488 CB THR 213 17982280 3683 140-119 -423ATOM 1489 OG1 THR 213 21.638 13.695 62.629 1.000 25.33ANISOU 1489 OG1 THR 213 25713378 3676 92571528ATOM 1490 CG2 THR 213 21.087 15.985 62.485 1.000 21.11ANISOU 1490 CG2 THR 213 19352667 3420 -310 -289 -747ATOM 1491 C THR 213 18.391 15.277 63.641 1.000 15.53ANISOU 1491 C THR 213 17322135 2032 111-557 -167ATOM 1492 O THR 213 17.533 15.195 62.761 1.000 16.11ANISOU 1492 O THR 213 17422197 2180 -327 -669 56ATOM 1493 N ASP 214 18.362 16.199 64.590 1.000 15.60ANISOU 1493 N ASP 214 20252046 1857 64 -405 2ATOM 1494 CA ASP 214 17.380 17.256 64.672 1.000 15.59ANISOU 1494 CA ASP 214 21301722 2072 2 -1010 -242ATOM 1495 CB ASP 214 17.744 18.200 65.822 1.000 17.13ANISOU 1495 CB ASP 214 25281893 2086 -226 -1022 -247ATOM 1496 CG ASP 214 17.612 17.672 67.219 1.000 20.21ANISOU 1496 CG ASP 214 31382495 2045 -451 -1276 -148ATOM 1497 OD1 ASP 214 17.079 16.571 67.460 1.000 20.87ANISOU 1497 OD1 ASP 214 27782632 2518 -247 -505 151ATOM 1498 OD2 ASP 214 18.076 18.401 68.127 1.000 28.05ANISOU 1498 OD2 ASP 214 51103118 2429 -257 -1997 -619ATOM 1499 C ASP 214 17.314 18.146 63.441 1.000 15.14ANISOU 1499 C ASP 214 20291822 1901 182 -574 -319ATOM 1500 O ASP 214 18.349 18.552 62.897 1.000 17.63ANISOU 1500 O ASP 214 19562032 2710 -214 -810 -15ATOM 1501 N LEU 215 16.105 18.493 63.027 1.000 14.69ANISOU 1501 N LEU 215 19361758 1887 38-334 242ATOM 1502 CA LEU 215 15.915 19.504 61.979 1.000 13.35ANISOU 1502 CA LEU 215 18201753 1498 89-22 59ATOM 1503 CB LEU 215 15.352 18.819 60.734 1.000 14.24ANISOU 1503 CB LEU 215 17352167 1506 -98 75-3ATOM 1504 CG LEU 215 16.291 17.813 60.056 1.000 16.39ANISOU 1504 CG LEU 215 20312285 1911 -340 320 -424ATOM 1505 CD1 LEU 215 15.517 16.999 59.031 1.000 22.61ANISOU 1505 CD1 LEU 215 31392024 3427 -10 -801 -877ATOM 1506 CD2 LEU 215 17.482 18.543 59.434 1.000 26.93ANISOU 1506 CD2 LEU 215 19985409 2827 -1083 909 -542ATOM 1507 C LEU 215 15.002 20.622 62.500 1.000 14.65ANISOU 1507 C LEU 215 17701607 2190 86-165 -95ATOM 1508 O LEU 215 13.822 20.662 62.151 1.000 19.45ANISOU 1508 O LEU 215 17482165 3476 116 -303 -203ATOM 1509 N PRO 216 15.552 21.523 63.314 1.000 15.99ANISOU 1509 N PRO 216 23901970 1715 -164 21-175ATOM 1510 CD PRO 216 16.955 21.601 63.757 1.000 19.37ANISOU 1510 CD PRO 216 29002306 2155 -83 -790 -548ATOM 1511 CA PRO 216 14.760 22.620 63.846 1.000 18.68ANISOU 1511 CA PRO 216 31042017 1976 12-74 -420ATOM 1512 CB PRO 216 15.649 23.227 64.949 1.000 18.63ANISOU 1512 CB PRO 216 35921517 1971 -120 -421 9ATOM 1513 CG PRO 216 17.030 22.847 64.581 1.000 22.35ANISOU 1513 CG PRO 216 34012426 2666 -419 -427 -783ATOM 1514 C PRO 216 14.461 23.700 62.819 1.000 18.50ANISOU 1514 C PRO 216 29212083 2026 58-465 -473ATOM 1515 O PRO 216 15.024 23.854 61.731 1.000 19.82ANISOU 1515 O PRO 216 27522453 2325 -32 -375 19ATOM 1516 N TYR 217 13.487 24.536 63.194 1.000 20.05ANISOU 1516 N TYR 217 32131981 2422 90-482 -718ATOM 1517 CA TYR 217 13.178 25.662 62.308 1.000 22.97ANISOU 1517 CA TYR 217 28492652 3227 211 -1467 -313ATOM 1518 C TYR 217 14.347 26.647 62.283 1.000 23.92ANISOU 1518 C TYR 217 41392131 2819 -337 -1776 -165ATOM 1519 O TYR 217 15.149 26.726 63.213 1.000 30.46ANISOU 1519 O TYR 217 43213440 3812 -1118 -2477 728ATOM 1520 CB TYR 217 11.891 26.314 62.768 1.000 32.68ANISOU 1520 CB TYR 217 39583294 5164 1148 -874 -783ATOM 1521 CG TYR 217 12.064 27.462 63.718 1.000 44.77ANISOU 1521 CG TYR 217 68294326 5854 895 38-1870ATOM 1522 CD1 TYR 217 11.853 28.763 63.285 1.000 54.26ANISOU 1522 CD1 TYR 217 10311 3688 6615 -323 132 -1945ATOM 1523 CD2 TYR 217 12.428 27.243 65.043 1.000 57.77ANISOU 1523 CD2 TYR 217 10635 5155 6158 -1027 -1446 -1931ATOM 1524 CE1 TYR 217 12.011 29.816 64.174 1.000 60.33ANISOU 1524 CE1 TYR 217 11807 4345 6772 -1101 -132 -2259ATOM 1525 CE2 TYR 217 12.585 28.296 65.926 1.000 64.51ANISOU 1525 CE2 TYR 217 12481 5199 6832 -1936 -1520 -2074ATOM 1526 CZ TYR 217 12.378 29.586 65.481 1.000 64.11ANISOU 1526 CZ TYR 217 12047 5183 7129 -1460 -817 -2160ATOM 1527 OH TYR 217 12.536 30.639 66.358 1.000 63.69ANISOU 1527 OH TYR 217 11840 5206 7153 -1832 -1191 -2064ATOM 1528 N ARG 218 14.418 27.374 61.188 1.000 24.08ANISOU 1528 N ARG 218 44821611 3055 507 -1471 -145ATOM 1529 CA ARG 218 15.335 28.465 60.948 1.000 30.71ANISOU 1529 CA ARG 218 59322490 3245 -504 -1565 382ATOM 1530 CB ARG 218 16.326 28.135 59.840 1.000 35.08ANISOU 1530 CB ARG 218 59692797 4562 -1397 -779 -348ATOM 1531 CG ARG 218 17.401 27.114 60.073 1.000 35.77ANISOU 1531 CG ARG 218 60093087 4497 -1107 -733 -773ATOM 1532 CD ARG 218 18.658 27.775 60.626 1.000 34.46ANISOU 1532 CD ARG 218 56803264 4152 -1242 -244 -619ATOM 1533 NE ARG 218 19.223 28.746 59.709 1.000 29.51ANISOU 1533 NE ARG 218 47072579 3926 7881-629ATOM 1534 CZ ARG 218 20.218 28.620 58.830 1.000 33.18ANISOU 1534 CZ ARG 218 52693166 4170 60452 -1075ATOM 1535 NH1 ARG 218 20.839 27.452 58.709 1.000 27.44ANISOU 1535 NH1 ARG 218 42022881 3341 -503 -373 -1585ATOM 1536 NH2 ARG 218 20.583 29.675 58.077 1.000 22.96ANISOU 1536 NH2 ARG 218 23273579 2817 233 -1117 -872ATOM 1537 C ARG 218 14.513 29.655 60.464 1.000 31.05ANISOU 1537 C ARG 218 73531949 2496 -448 -1823 197ATOM 1538 O ARG 218 14.114 29.533 59.295 1.000 40.40ANISOU 1538 O ARG 218 98732241 3235 531 -3168 -627ATOM 1539 N PRO 219 14.246 30.747 61.157 1.000 30.01ANISOU 1539 N PRO 219 62902559 2555 -499 -1839 -284ATOM 1540 CD PRO 219 14.597 31.043 62.543 1.000 36.79ANISOU 1540 CD PRO 219 81472878 2954 -1848 -2548 -374ATOM 1541 CA PRO 219 13.464 31.841 60.549 1.000 26.34ANISOU 1541 CA PRO 219 44212564 3025 -573 -988 -340ATOM 1542 CB PRO 219 13.523 32.993 61.563 1.000 32.44ANISOU 1542 CB PRO 219 53612891 4073 -691 -417 -989ATOM 1543 CG PRO 219 13.947 32.372 62.825 1.000 38.75ANISOU 1543 CG PRO 219 79163462 3344 -1981 -958 -1235ATOM 1544 C PRO 219 14.005 32.329 59.220 1.000 23.64ANISOU 1544 C PRO 219 34722066 3443 -161 -1028 109ATOM 1545 O PRO 219 13.300 32.950 58.412 1.000 30.61ANISOU 1545 O PRO 219 43582934 4339 -347 -1712 876ATOM 1546 N ASP 220 15.269 32.087 58.906 1.000 25.98ANISOU 1546 N ASP 220 36111756 4506 -389 -644 -815ATOM 1547 CA ASP 220 15.847 32.660 57.705 1.000 27.96ANISOU 1547 CA ASP 220 39511603 5071 -364 30-824ATOM 1548 CB ASP 220 17.212 33.238 58.155 1.000 29.61ANISOU 1548 CB ASP 220 35493142 4558 -176 -326 176ATOM 1549 CG ASP 220 18.091 32.158 58.780 1.000 32.09ANISOU 1549 CG ASP 220 37063527 4961 625 978 615ATOM 1550 OD1 ASP 220 17.697 31.434 59.719 1.000 26.12ANISOU 1550 OD1 ASP 220 30133522 3390 -158 -289 -97ATOM 1551 OD2 ASP 220 19.241 32.088 58.281 1.000 29.09ANISOU 1551 OD2 ASP 220 37143756 3581 304 677 -712ATOM 1552 C ASP 220 16.037 31.726 56.525 1.000 25.26ANISOU 1552 C ASP 220 25081291 5800 354 1110 -822ATOM 1553 O ASP 220 16.641 32.095 55.515 1.000 28.28ANISOU 1553 O ASP 220 40881665 4994 -855 298 -434ATOM 1554 N ALA 221 15.500 30.510 56.631 1.000 21.58ANISOU 1554 N ALA 221 27481770 3681 -288 178 -651ATOM 1555 CA ALA 221 15.840 29.484 55.658 1.000 19.81ANISOU 1555 CA ALA 221 29861452 3090 -342 -224 -315ATOM 1556 CB ALA 221 17.130 28.800 56.109 1.000 19.51ANISOU 1556 CBALA 221 22671497 3647 -648 45-746ATOM1557 C ALA 221 14.718 28.46955.4891.000 17.71ANISOU 1557 C ALA 221 23041912 2512 -251 -75 -309ATOM1558 O ALA 221 13.866 28.35656.3801.000 20.97ANISOU 1558 O ALA 221 35962029 2344 -503 406 -284ATOM1559 N VAL 222 14.728 27.75654.3781.000 14.22ANISOU 1559 N VAL 222 15601582 2262 -76-92 -11ATOM1560 CAVAL 222 13.823 26.61754.1601.000 14.89ANISOU 1560 CAVAL 222 13261608 2723 98 -216 -205ATOM1561 CBVAL 222 13.079 26.77952.8301.000 17.28ANISOU 1561 CBVAL 222 16801754 3133 90 -657 -144ATOM1562 CG1 VAL 222 13.995 26.68551.6201.000 19.17ANISOU 1562 CG1 VAL 222 19742625 2686 -446 -775 150ATOM1563 CG2 VAL 222 11.996 25.74752.6411.000 17.36ANISOU 1563 CG2 VAL 222 21851879 2533 -254 -362 -385ATOM1564 C VAL 222 14.653 25.33954.2631.000 12.66ANISOU 1564 C VAL 222 11361564 2112 -50-225 -378ATOM1565 O VAL 222 15.828 25.32053.8931.000 13.12ANISOU 1565 O VAL 222 12801825 1881 104-13 -199ATOM1566 N LEU 223 14.049 24.26754.7751.000 12.98ANISOU 1566 N LEU 223 11231538 2270 -163 -370 -417ATOM1567 CALEU 223 14.681 22.95254.7491.000 10.70ANISOU 1567 CALEU 223 891 1704 1472 -26-98 -7ATOM1568 CBLEU 223 14.276 22.13055.9611.000 13.02ANISOU 1568 CBLEU 223 13871968 1593 -419 289 -108ATOM1569 CGLEU 223 14.739 20.68356.1061.000 17.41ANISOU 1569 CGLEU 223 24342132 2050 -290 -476 566ATOM1570 CD1 LEU 223 16.247 20.61456.2041.000 17.20ANISOU 1570 CD1 LEU 223 25761518 2441 26 -989 -249ATOM1571 CD2 LEU 223 13.983 20.07657.2821.000 33.63ANISOU 1571 CD2 LEU 223 39814721 4077 -341 134 2949ATOM1572 C LEU 223 14.362 22.21153.4561.000 10.02ANISOU 1572 C LEU 223 10001265 1543 58 -319 88ATOM1573 O LEU 223 13.206 22.16053.0881.000 12.86ANISOU 1573 O LEU 223 949 1945 992 -97-174 -372ATOM1574 N VAL 224 15.406 21.67552.7981.000 10.55ANISOU 1574 N VAL 224 978 1070 1962 -76-418 -382ATOM1575 CAVAL 224 15.227 20.93251.5531.000 11.98ANISOU 1575 CAVAL 224 13761288 1887 -249 -278 -372ATOM1576 CBVAL 224 16.095 21.46150.3911.000 11.23ANISOU 1576 CBVAL 224 901 1541 1824 -279 -622 -99ATOM1577 CG1 VAL 224 15.833 20.69049.1021.000 13.16ANISOU 1577 CG1 VAL 224 18991485 1615 -462 -516 84ATOM1578 CG2 VAL 224 15.837 22.94150.1561.000 13.86ANISOU 1578 CG2 VAL 224 14801520 2266 -135 -354 -64ATOM1579 C VAL 224 15.539 19.45051.7861.000 10.87ANISOU 1579 C VAL 224 953 1275 1901 -13342 -484ATOM1580 O VAL 224 16.646 19.14852.2011.000 12.57ANISOU 1580 O VAL 224 12831363 2132 -175 -154 -274ATOM1581 N PHE 225 14.585 18.55351.5331.000 11.86ANISOU 1581 N PHE 225 12411128 2137 -15-303 -61ATOM1582 CAPHE 225 14.811 17.13051.4121.000 11.38ANISOU 1582 CAPHE 225 12601157 1909 -22-67 -56ATOM1583 CBPHE 225 13.707 16.28052.0441.000 11.34ANISOU 1583 CBPHE 225 11171176 2015 205-213 335ATOM1584 CGPHE 225 13.654 16.17253.5441.000 11.38ANISOU 1584 CGPHE 225 964 1369 1991 -251 -333 181ATOM1585 CD1 PHE 225 14.685 15.65354.2911.000 15.28ANISOU 1585 CD1 PHE 225 17711777 2256 -98-853 298ATOM1586 CD2 PHE 225 12.532 16.57654.2541.000 17.91ANISOU 1586 CD2 PHE 225 19042748 2153 341106 0ATOM1587 CE1 PHE 225 14.619 15.53555.6611.000 17.46ANISOU 1587 CE1 PHE 225 24491862 2321 -249 -795 666ATOM1588 CE2 PHE 225 12.447 16.47455.6121.000 19.35ANISOU 1588 CE2 PHE 225 25632678 2111 121129 -11ATOM1589 CZ PHE 225 13.499 15.94556.3411.000 18.20ANISOU 1589 CZ PHE 225 29521641 2324 -501 -470 36ATOM1590 CPHE 225 14.907 16.77449.9271.000 12.03ANISOU 1590 CPHE 225 14801285 1804 130-201 42ATOM1591 OPHE 225 14.019 17.16049.1631.000 12.77ANISOU 1591 OPHE 225 14731466 1912 341-118 38ATOM1592 NCYS 226 15.940 16.03249.5211.000 9.62ANISOU 1592 NCYS 226 954 1403 1296 -204 -407 29ATOM1593 CA CYS 226 15.917 15.40048.1971.000 10.80ANISOU 1593 CA CYS 226 14321204 1468 -258 -310 -59ATOM1594 CB CYS 226 17.337 15.02947.7441.000 12.02ANISOU 1594 CB CYS 226 15391362 1666 -357 16-125ATOM1595 SG CYS 226 18.426 16.49047.5541.000 13.74ANISOU 1595 SG CYS 226 16271400 2192 -341 18139ATOM1596 CCYS 226 14.998 14.17848.2561.000 9.86ANISOU 1596 CCYS 226 11901061 1495 -20-293 -16ATOM1597 OCYS 226 15.015 13.43149.2521.000 11.17ANISOU 1597 OCYS 226 11811280 1781 -129 -435 272ATOM1598 NGLY 227 14.217 13.96347.2051.000 10.17ANISOU 1598 NGLY 227 14281010 1427 -258 -271 -35ATOM1599 CA GLY 227 13.370 12.80647.0531.000 9.73ANISOU 1599 CA GLY 227 1231860 1604 -178 -74 -37ATOM1600 CGLY 227 13.908 11.76946.0741.000 9.48ANISOU 1600 CGLY 227 1438717 1445 16 -35 169ATOM1601 OGLY 227 14.935 11.96145.4021.000 9.86ANISOU 1601 OGLY 227 13211137 1290 -104 -179 78ATOM1602 NALA 228 13.217 10.63145.9711.000 9.17ANISOU 1602 NALA 228 1279729 1477 109-135 58ATOM1603 CA ALA 228 13.650 9.529 45.1081.000 9.41ANISOU 1603 CA ALA 228 1315887 1371 9 -74 -52ATOM1604 CB ALA 228 12.727 8.296 45.2561.000 10.50ANISOU 1604 CB ALA 228 2011824 1155 -143 124 101ATOM1605 CALA 228 13.712 9.918 43.6371.000 9.25ANISOU 1605 CALA 228 1343666 1507 -108 90139ATOM1606 OALA 228 14.493 9.305 42.8951.000 9.48ANISOU 1606 OALA 228 11711026 1405 -88-50 90ATOM1607 NILE 229 12.970 10.90743.1431.000 10.30ANISOU 1607 NILE 229 14021004 1509 18 25177ATOM1608 CA ILE 229 13.074 11.31141.7271.000 10.87ANISOU 1608 CA ILE 229 11971446 1487 -2 -159 251ATOM1609 CB ILE 229 11.802 12.07841.2951.000 11.52ANISOU 1609 CB ILE 229 12571473 1647 34 -57 362ATOM1610 CG2 ILE 229 11.997 12.85239.9991.000 11.30ANISOU 1610 CG2 ILE 229 16551211 1426 83 -189 156ATOM1611 CG1 ILE 229 10.575 11.13141.2371.000 14.39ANISOU 1611 CG1 ILE 229 10312034 2402 -40210 311ATOM1612 CD1 ILE 229 10.676 10.09340.1381.000 19.20ANISOU 1612 CD1 ILE 229 20851723 3489 -610 93-138ATOM1613 CILE 229 14.389 12.03441.4771.000 10.38ANISOU 1613 CILE 229 12931405 1247 -62-169 322ATOM1614 OILE 229 14.952 11.94740.3691.000 11.66ANISOU 1614 OILE 229 18051257 1368 -13145 328ATOM1615 NALA 230 14.965 12.69242.4901.000 10.66ANISOU 1615 NALA 230 14761274 1300 -104 -151 356ATOM1616 CA ALA 230 16.312 13.25942.3381.000 11.21ANISOU 1616 CA ALA 230 1473975 1813 -57-308 90ATOM1617 CB ALA 230 16.681 14.14843.5091.000 10.58ANISOU 1617 CB ALA230 13501295 1375 62 -106 126ATOM1618 CALA230 17.336 12.13642.1321.000 11.28ANISOU 1618 CALA230 16401037 1610 1 55242ATOM1619 OALA230 18.220 12.18541.2731.000 11.29ANISOU 1619 OALA230 15101240 1539 -189 -40 288ATOM1620 NTHR231 17.173 11.09742.9461.000 10.55ANISOU 1620 NTHR231 1328894 1787 -262 -70 214ATOM1621 CA THR231 18.064 9.939 42.8191.000 11.98ANISOU 1621 CA THR231 19291018 1605 0 -164 159ATOM1622 CB THR231 17.717 8.865 43.8781.000 10.76ANISOU 1622 CB THR231 13811070 1636 -86-453 246ATOM1623 OG1 THR231 17.658 9.437 45.1981.000 11.82ANISOU 1623 OG1 THR231 16151236 1641 35 -115 277ATOM1624 CG2 THR231 18.765 7.752 43.8801.000 12.57ANISOU 1624 CG2 THR231 16211314 1840 160-89 351ATOM1625 CTHR231 17.958 9.352 41.4151.000 12.52ANISOU 1625 CTHR231 16321500 1624 -145 4211ATOM1626 OTHR231 18.939 9.050 40.7321.000 12.15ANISOU 1626 OTHR231 16361233 1747 -1786224ATOM1627 NLEU232 16.717 9.154 40.9591.000 11.14ANISOU 1627 NLEU232 16081005 1620 90 -68 141ATOM1628 CA LEU232 16.446 8.522 39.6751.000 12.47ANISOU 1628 CA LEU232 18801203 1657 109-169 45ATOM1629 CB LEU232 14.950 8.214 39.5521.000 12.81ANISOU 1629 CB LEU232 19891225 1654 -78-209 19ATOM1630 CG LEU232 14.452 7.464 38.3141.000 14.85ANISOU 1630 CG LEU232 21711753 1719 -5 -410 -96ATOM1631 CD1 LEU232 15.020 6.055 38.2401.000 16.78ANISOU 1631 CD1 LEU232 26931749 1932 72 -431 -487ATOM1632 CD2 LEU232 12.914 7.411 38.2911.000 15.70ANISOU 1632 CD2 LEU232 21801866 1920 -278 -589 494ATOM1633 CLEU232 16.964 9.354 38.5111.000 11.58ANISOU 1633 CLEU232 14521390 1559 309-301 136ATOM1634 OLEU232 17.752 8.837 37.6861.000 13.45ANISOU 1634 OLEU232 18081436 1867 320-17 30ATOM1635 NVAL233 16.565 10.61738.4141.000 10.95ANISOU 1635 NVAL233 14281210 1522 -14-210 0ATOM1636 CA VAL233 16.948 11.42137.2421.000 11.70ANISOU 1636 CA VAL233 17031345 1397 97 5 13ATOM1637 CB VAL233 16.156 12.74337.2151.000 11.14ANISOU 1637 CB VAL233 16721272 1287 -26276 73ATOM1638 CG1 VAL233 16.661 13.77438.2491.000 13.34ANISOU 1638 CG1 VAL233 18341562 1673 -205 653 -368ATOM1639 CG2 VAL233 16.106 13.41235.8271.000 14.66AMISOU 1639 CG2 VAL233 19921873 1704 -4 -45 586ATOM1640 CVAL233 18.459 11.58637.1321.000 13.41ANISOU 1640 CVAL233 17121573 1811 91 151 125ATOM1641 OVAL233 19.012 11.62736.0211.000 13.45ANISOU 1641 OVAL233 18441402 1866 46 192 438ATOM1642 NTHR234 19.188 11.66538.2501.000 13.13ANISOU 1642 NTHR234 14571639 1893 -139 223 126ATOM1643 CA THR234 20.613 11.93038.2441.000 13.00AMISOU 1643 CA THR234 14831600 1855 -188 428 143ATOM1644 CB THR234 21.069 12.72639.4651.000 12.46ANISOU 1644 CB THR234 13001632 1803 -32200 251ATOM1645 OG1 THR234 20.825 11.94140.6391.000 13.71ANISOU 1645 OG1 THR234 16601662 1888 192202 291ATOM1646 CG2 THR234 20.301 14.02739.6431.000 11.37ANISOU 1646 CG2 THR234 10971565 1657 -153 -87 169ATOM1647 CTHR234 21.424 10.64338.1781.000 14.44ANISOU 1647 CTHR234 15501823 2114 6 -73 -53ATOM 1648 O THR 234 22.659 10.71038.2331.000 15.81ANISOU 1648 O THR 234 15462169 2293 6127217ATOM 1649 N GLY 235 20.767 9.477 38.0701.000 14.76ANISOU 1649 N GLY 235 17761576 2254 7781410ATOM 1650 CA GLY 235 21.530 8.249 37.9941.000 16.69ANISOU 1650 CA GLY 235 20531803 2486 304 35189ATOM 1651 C GLY 235 22.243 7.862 39.2751.000 16.83ANISOU 1651 C GLY 235 18542031 2512 765 244 193ATOM 1652 O GLY 235 23.305 7.237 39.1941.000 19.67ANISOU 1652 O GLY 235 20742172 3225 1035 383 372ATOM 1653 N GLY 236 21.665 8.227 40.4251.000 14.46ANISOU 1653 N GLY 236 17321327 2433 154 198 75ATOM 1654 CA GLY 236 22.187 7.768 41.6921.000 15.73ANISOU 1654 CA GLY 236 20601381 2536 41186 312ATOM 1655 C GLY 236 23.166 8.691 42.3881.000 14.76ANISOU 1655 C GLY 236 19311332 2346 252 73288ATOM 1656 O GLY 236 23.778 8.244 43.3731.000 18.32ANISOU 1656 O GLY 236 19832197 2782 106 -105 844ATOM 1657 N GLN 237 23.318 9.938 41.9531.000 13.99ANISOU 1657 N GLN 237 18311349 2137 158 165 170ATOM 1658 CA GLN 237 24.209 10.95642.4851.000 13.13ANISOU 1658 CA GLN 237 14741304 2210 367 -31 276ATOM 1659 CB GLN 237 24.629 11.94841.3831.000 13.38ANISOU 1659 CB GLN 237 13671566 2151 9972159ATOM 1660 CG GLN 237 25.390 11.33540.2191.000 14.74ANISOU 1660 CG GLN 237 14041529 2666 518 410 333ATOM 1661 CD GLN 237 25.816 12.42839.2571.000 17.22ANISOU 1661 CD GLN 237 20392018 2486 -64 426 360ATOM 1662 OE1 GLN 237 26.754 13.20839.5221.000 20.60ANISOU 1662 OE1 GLN 237 15662334 3928 -10 -29 965ATOM 1663 NE2 GLN 237 25.116 12.47038.1271.000 17.47ANISOU 1663 NE2 GLN 237 20142093 2533 208 438 408ATOM 1664 C GLN 237 23.627 11.73943.6631.000 12.90ANISOU 1664 C GLN 237 14741324 2104 72-10 255ATOM 1665 O GLN 237 24.332 12.54944.2821.000 15.90ANISOU 1665 O GLN 237 17391888 2413 -291 74-84ATOM 1666 N VAL 238 22.365 11.48144.0131.000 12.13ANISOU 1666 N VAL 238 1372962 2276 212 -33 200ATOM 1667 CA VAL 238 21.664 12.18245.0821.000 11.91ANISOU 1667 CA VAL 238 11691436 1920 -121 -276 -19ATOM 1668 CB VAL 238 20.622 13.15844.5101.000 12.00ANISOU 1668 CB VAL 238 10241179 2357 -6199 -31ATOM 1669 CG1 VAL 238 19.978 13.99945.6011.000 13.07ANISOU 1669 CG1 VAL 238 15301668 1767 63-232 -222ATOM 1670 CG2 VAL 238 21.207 14.08843.4631.000 14.00ANISOU 1670 CG2 VAL 238 17951470 2053 -40 -2181ATOM 1671 C VAL 238 20.990 11.15646.0001.000 13.62ANISOU 1671 C VAL 238 17071415 2054 -103 -40 -22ATOM 1672 O VAL 238 20.252 10.28845.4921.000 12.64ANISOU 1672 O VAL 238 1702977 2123 60-318 257ATOM 1673 N LYS 239 21.247 11.24647.3001.000 11.99ANISOU 1673 N LYS 239 10751404 2076 127 -101 74ATOM 1674 CA LYS 239 20.568 10.44448.3221.000 12.77ANISOU 1674 CA LYS 239 12241541 2088 -12 -124 86ATOM 1675 CB LYS 239 21.382 10.46349.6221.000 12.23ANISOU 1675 CB LYS 239 13331155 2158 183 -234 -28ATOM 1676 CG LYS 239 20.953 9.626 50.7931.000 13.85ANISOU 1676 CG LYS 239 16431689 1931 187 -52 -89ATOM 1677 CD LYS 239 21.927 9.579 51.9571.000 20.13ANISOU 1677 CD LYS 239 28931795 2961 10-1185 588ATOM 1678 CE LYS 239 21.364 8.745 53.0981.000 24.73ANISOU 1678 CELYS 239 40652250 3080 -348 -1466 1064ATOM1679 NZLYS 239 22.019 8.841 54.4201.000 32.28ANISOU 1679 NZLYS 239 56584315 2293 1610 -930 -304ATOM1680 C LYS 239 19.169 10.94948.6611.000 11.59ANISOU 1680 C LYS 239 12071332 1866 -35-82 64ATOM1681 O LYS 239 18.976 12.19148.7081.000 12.32ANISOU 1681 O LYS 239 16381294 1749 -2 -25 236ATOM1682 N ALA 240 18.222 10.04748.8631.000 10.65ANISOU 1682 N ALA 240 12481266 1534 -52-185 -88ATOM1683 CAALA 240 16.884 10.36849.3541.000 10.21ANISOU 1683 CAALA 240 12921057 1531 -195 -37 -109ATOM1684 CBALA 240 15.784 9.782 48.4661.000 13.46ANISOU 1684 CBALA 240 11952378 1543 -232 20-403ATOM1685 C ALA 240 16.784 9.881 50.8071.000 10.97ANISOU 1685 C ALA 240 13081249 1611 -127 -142 49ATOM1686 O ALA 240 16.595 8.664 51.0591.000 13.02ANISOU 1686 O ALA 240 21361242 1568 -243 28-7ATOM1687 N PRO 241 16.967 10.78351.7821.000 11.13ANISOU 1687 N PRO 241 17231041 1466 160-49 138ATOM1688 CDPRO 241 17.172 12.23751.6541.000 11.17ANISOU 1688 CDPRO 241 14191204 1618 -180 -128 76ATOM1689 CAPRO 241 17.043 10.34053.1661.000 11.96ANISOU 1689 CAPRO 241 15971447 1499 -172 -32 193ATOM1690 CBPRO 241 17.712 11.54553.8911.000 14.25ANISOU 1690 CBPRO 241 18751837 1701 -531 -383 242ATOM1691 CGPRO 241 17.286 12.72453.0691.000 13.61ANISOU 1691 CGPRO 241 20151446 1709 -596 -465 -22ATOM1692 C PRO 241 15.708 10.07253.8611.000 12.35ANISOU 1692 C PRO 241 14171610 1665 -175 -187 418ATOM1693 O PRO 241 14.759 10.82953.6551.000 12.28ANISOU 1693 O PRO 241 13591582 1723 -232 -468 81ATOM1694 N ARG 242 15.700 9.033 54.7111.000 12.75ANISOU 1694 N ARG 242 17751407 1664 -170 76250ATOM1695 CAARG 242 14.563 8.804 55.5761.000 10.76ANISOU 1695 CAARG 242 12921417 1380 -207 -281 211ATOM1696 CBARG 242 14.614 7.405 56.2231.000 15.02ANISOU 1696 CBARG 242 24191368 1918 -357 117 294ATOM1697 CGARG 242 14.115 6.342 55.2301.000 17.85ANISOU 1697 CGARG 242 33731274 2135 9 -560 251ATOM1698 CDARG 242 14.254 4.934 55.7631.000 19.42ANISOU 1698 CDARG 242 31481111 3120 506503 116ATOM1699 NEARG 242 15.667 4.552 55.8491.000 20.71ANISOU 1699 NEARG 242 32252107 2538 938638 212ATOM1700 CZARG 242 16.107 3.444 56.4161.000 23.22ANISOU 1700 CZARG 242 31982206 3417 307-544 589ATOM1701 NH1 ARG 242 15.285 2.567 56.9801.000 24.46ANISOU 1701 NH1 ARG 242 40972112 3083 307387 195ATOM1702 NH2 ARG 242 17.416 3.184 56.4381.000 25.41ANISOU 1702 NH2 ARG 242 34022332 3921 819-267 403ATOM1703 C ARG 242 14.477 9.834 56.7041.000 11.95ANISOU 1703 C ARG 242 15711463 1506 -248 -214 107ATOM1704 O ARG 242 15.469 10.37757.2131.000 13.65ANISOU 1704 O ARG 242 17081439 2040 -322 -401 -38ATOM1705 N HIS 243 13.252 10.08557.1181.000 11.60ANISOU 1705 N HIS 243 16571410 1342 -311 -206 5ATOM1706 CAHIS 243 12.942 11.05658.1581.000 11.49ANISOU 1706 CAHIS 243 18551571 938 -306 -183 140ATOM1707 CBHIS 243 12.968 12.46257.5461.000 11.22ANISOU 1707 CBHIS 243 14321379 1453 -231 -221 39ATOM1708 CGHIS 543 12.133 12.69456.3411.000 11.80ANISOU 1708 CGHIS 243 19371171 1378 -31-268 79ATOM1709 CD2 HIS243 10.885 13.23656.1811.000 11.15ANISOU 1709 CD2 HIS243 19901106 1142 35 -344 141ATOM1710 ND1 HIS243 12.538 12.34555.0861.000 12.29ANISOU 1710 ND1 HIS243 16701606 1395 -394 -91 8ATOM1711 CE1 HIS243 11.599 12.65354.2091.000 12.59ANISOU 1711 CE1 HIS243 16861740 1357 -522 -202 -253ATOM1712 NE2 HIS243 10.585 13.20454.8411.000 10.77ANISOU 1712 NE2 HIS243 16121307 1172 -616 -268 -36ATOM1713 CHIS243 11.605 10.73758.8121.000 12.49ANISOU 1713 CHIS243 18691570 1308 -321 -53 73ATOM1714 OHIS243 10.807 9.949 58.2711.000 12.26ANISOU 1714 OHIS243 17561404 1497 -188 -115 47ATOM1715 NHIS244 11.352 11.31959.9831.000 12.16ANISOU 1715 NHIS244 14641715 1442 -230 -112 -32ATOM1716 CA HIS244 10.138 11.04360.7581.000 12.02ANISOU 1716 CA HIS244 16061809 1152 -599 -167 -24ATOM1717 CB HIS244 10.255 9.778 61.6151.000 12.51ANISOU 1717 CB HIS244 16551763 1334 -19101 -47ATOM1718 CG HIS244 11.270 9.810 62.6981.000 15.04ANISOU 1718 CG HIS244 20251723 1965 -178 -433 154ATOM1719 CD2 HIS244 11.276 10.38063.9231.000 18.19ANISOU 1719 CD2 HIS244 29462339 1627 36 -732 297ATOM1720 ND1 HIS244 12.504 9.203 62.6621.000 19.30ANISOU 1720 ND1 HIS244 23032232 2800 229-708 266ATOM1721 CE1 HIS244 13.226 9.387 63.7311.000 22.48ANISOU 1721 CE1 HIS244 26492734 3159 11 -1206 650ATOM1722 NE2 HIS244 12.476 10.12064.5311.000 22.33ANISOU 1722 NE2 HIS244 30882895 2500 -272 -1236 384ATOM1723 CHIS244 9.780 12.24661.6131.000 13.47ANISOU 1723 CHIS244 18971673 1549 -362 254 67ATOM1724 OHIS244 10.603 13.16561.7981.000 13.48ANISOU 1724 OHIS244 18001726 1595 -283 139 -161ATOM1725 NVAL245 8.551 12.24562.1301.000 15.26ANISOU 1725 NVAL245 18521964 1983 -417 232 -55ATOM1726 CA VAL245 8.090 13.35262.9701.000 17.31ANISOU 1726 CA VAL245 21082442 2026 -125 476 -161ATOM1727 CB VAL245 6.939 14.16962.3601.000 17.33ANISOU 1727 CB VAL245 20942473 2019 -80340 -477ATOM1728 CG1 VAL245 6.551 15.33463.2861.000 25.25ANISOU 1728 CG1 VAL245 22172966 4410 -137 1939 -1248ATOM1729 CG2 VAL245 7.252 14.71360.9661.000 21.49ANISOU 1729 CG2 VAL245 30702538 2556 -180 313 271ATOM1730 CVAL245 7.682 12.76864.3271.000 18.29ANISOU 1730 CVAL245 21232689 2137 -443 508 -71ATOM1731 OVAL245 6.765 11.94564.4291.000 18.62ANISOU 1731 OVAL245 18102174 3089 -15451 254ATOM1732 NALA246 8.385 13.20265.3691.000 21.54ANISOU 1732 NALA246 28133045 2327 -591 -407 907ATOM1733 CA ALA246 8.133 12.70166.7191.000 25.10ANISOU 1733 CA ALA246 45962562 2379 94 -225 997ATOM1734 CB ALA246 9.424 12.72367.5371.000 29.82ANISOU 1734 CB ALA246 53813408 2540 402-889 1325ATOM1735 CALA246 7.080 13.54567.4121.000 31.20ANISOU 1735 CALA246 50794143 2632 314280 428ATOM1736 OALA246 6.876 14.71467.0521.000 32.39ANISOU 1736 OALA246 47063748 3853 5671247 -66ATOM1737 NALA247 6.429 12.97368.4131.000 37.30ANISOU 1737 NALA247 55485498 3126 92 640 835ATOM1738 CA ALA247 5.585 13.79469.2711.000 40.42ANISOU 1738 CA ALA247 54346048 3878 15 1313 850ATOM1739 CALA247 6.289 14.13270.5781.000 42.17ANISOU 1739 CALA 247 6495 5891 3636 -823 1720 341ATOM1740 OALA 247 7.048 13.33871.136 1.000 41.63ANISOU 1740 OALA 247 5811 6371 3637 -1631 804 425ATOM1741 CB ALA 247 4.280 13.06769.525 1.000 47.17ANISOU 1741 CB ALA 247 5186 9059 3676 -520 523 2683ATOM1742 NSER 257 1.781 21.84870.382 1.000 31.02ANISOU 1742 NSER 257 4109 5558 2119 137-235 -810ATOM1743 CA SER 257 1.214 21.93269.052 1.000 27.01ANISOU 1743 CA SER 257 2792 5165 2304 109-143 -707ATOM1744 CB SER 257 0.039 22.91468.992 1.000 28.16ANISOU 1744 CB SER 257 2655 4473 3572 -238 -90 -1071ATOM1745 OG SER 257 0.491 24.25169.074 1.000 51.32ANISOU 1745 OG SER 257 8516 4131 6853 -616 -2734 -807ATOM1746 CSER 257 2.259 22.38968.034 1.000 26.19ANISOU 1746 CSER 257 2537 5064 2350 -132 -413 -527ATOM1747 OSER 257 3.286 22.98868.352 1.000 31.47ANISOU 1747 OSER 257 2740 5886 3330 -435 -689 -639ATOM1748 NARG 258 2.022 22.12366.763 1.000 26.04ANISOU 1748 NARG 258 3257 4477 2161 -238 -441 -19ATOM1749 CA ARG 258 2.982 22.54165.747 1.000 25.81ANISOU 1749 CA ARG 258 2606 4735 2466 73 -338 -197ATOM1750 CARG 258 2.321 22.60964.383 1.000 18.26ANISOU 1750 CARG 258 2374 2541 2021 39 83-854ATOM1751 OARG 258 1.288 21.96764.131 1.000 19.23ANISOU 1751 OARG 258 2600 2819 1888 -389 311 -420ATOM1752 CB ARG 258 4.188 21.59265.664 1.000 29.78ANISOU 1752 CB ARG 258 3403 5052 2861 695-552 -57ATOM1753 CG ARG 258 4.246 20.78464.384 1.000 32.64ANISOU 1753 CG ARG 258 4358 4148 3896 14697-561ATOM1754 CD ARG 258 5.325 19.74664.499 1.000 30.38ANISOU 1754 CD ARG 258 3812 4423 3309 -57341 -16ATOM1755 NE ARG 258 6.433 19.90963.581 1.000 29.43ANISOU 1755 NE ARG 258 3990 4604 2588 -2270542ATOM1756 CZ ARG 258 6.453 19.38962.359 1.000 25.02ANISOU 1756 CZ ARG 258 2540 3893 3074 304-243 104ATOM1757 NH1 ARG 258 5.456 18.67761.835 1.000 22.88ANISOU 1757 NH1 ARG 258 2105 2607 3982 359315 289ATOM1758 NH2 ARG 258 7.523 19.59361.617 1.000 22.03ANISOU 1758 NH2 ARG 258 2477 2775 3120 -430 -287 -964ATOM1759 NTHR 259 2.927 23.41563.527 1.000 20.17ANISOU 1759 NTHR 259 2010 3640 2013 -743 91-1001ATOM1760 CA THR 259 2.485 23.50562.138 1.000 18.33ANISOU 1760 CA THR 259 1801 3043 2121 -533 43-685ATOM1761 CB THR 259 1.821 24.82161.713 1.000 23.23ANISOU 1761 CB THR 259 2082 3169 3576 -384 -164 -580ATOM1762 OG1 THR 259 2.839 25.83061.681 1.000 34.27ANISOU 1762 OG1 THR 259 2181 2562 8277 -137 -996 -794ATOM1763 CG2 THR 259 0.738 25.19862.704 1.000 25.49ANISOU 1763 CG2 THR 259 4466 2233 2987 325396 -948ATOM1764 CTHR 259 3.702 23.35261.222 1.000 18.44ANISOU 1764 CTHR 259 2035 2822 2150 -753 274 -583ATOM1765 OTHR 259 4.835 23.69861.603 1.000 24.74ANISOU 1765 OTHR 259 1961 5370 2069 -964 231 -714ATOM1766 NSER 260 3.420 22.86760.026 1.000 16.29ANISOU 1766 NSER 260 1971 2352 1864 -224 2 -75ATOM1767 CA SER 260 4.447 22.83258.989 1.000 17.43ANISOU 1767 CA SER 260 1783 2961 1879 321-95 -72ATOM1768 CB SER 260 5.224 21.51458.956 1.000 20.17ANISOU 1768 CB SER 260 2306 3257 2100 762-127 388ATOM1769 OG SER 260 4.416 20.39258.698 1.000 27.09ANISOU 1769 OG SER 260 3651 2803 3839 426217 554ATOM1770 C SER 260 3.832 23.06257.6141.000 14.52ANISOU 1770 C SER 260 1463 2165 1889 83 -100 -1ATOM1771 O SER 260 2.686 22.68157.4021.000 15.92ANISOU 1771 O SER 260 1513 2489 2049 -93-1257ATOM1772 N SER 261 4.617 23.66056.7421.000 13.45ANISOU 1772 N SER 261 1489 1832 1788 -190 -120 -500ATOM1773 CA SER 261 4.294 23.86455.3341.000 13.52ANISOU 1773 CA SER 261 1599 1726 1812 -204 30-315ATOM1774 C SER 261 5.209 22.94354.5451.000 12.45ANISOU 1774 C SER 261 1332 1887 1513 -42-240 -161ATOM1775 O SER 261 6.438 23.07254.6621.000 15.07ANISOU 1775 O SER 261 1344 1885 2497 -68-331 -343ATOM1776 CB SER 261 4.446 25.33054.9431.000 17.76ANISOU 1776 CB SER 261 2718 1625 2404 -399 -485 -318ATOM1777 OG SER 261 4.428 25.55453.5701.000 27.54ANISOU 1777 OG SER 261 4342 3308 2814 -719 -821 955ATOM1778 N VAL 262 4.623 22.04553.7821.000 10.90ANISOU 1778 N VAL 262 1215 1630 1299 41 -135 19ATOM1779 CA VAL 262 5.393 21.03153.0261.000 11.61ANISOU 1779 CA VAL 262 1334 1634 1442 156-103 17ATOM1780 CB VAL 262 5.026 19.63953.5581.000 11.87ANISOU 1780 CB VAL 262 1262 1636 1614 9 -187 -74ATOM1781 CG1VAL 262 5.778 18.57752.7791.000 13.12ANISOU 1781 CG1VAL 262 1462 1527 1997 -2 185 51ATOM1782 CG2VAL 262 5.262 19.56455.0621.000 17.08ANISOU 1782 CG2VAL 262 3390 1494 1604 -374 -245 39ATOM1783 C VAL 262 5.096 21.14951.5431.000 11.18ANISOU 1783 C VAL 262 1026 1790 1431 1 -111 -138ATOM1784 O VAL 262 3.939 20.96951.1271.000 12.76ANISOU 1784 O VAL 262 1064 2137 1648 -251 -84 -271ATOM1785 N PHE 263 6.090 21.43850.7141.000 9.50ANIS0U 1785 N PHE 263 995 1297 1316 -6 -210 -181ATOM1786 CA PHE 263 5.933 21.63749.2881.000 9.61ANISOU 1786 CA PHE 263 1310 1017 1324 -6 -284 -42ATOM1787 CB PHE 263 6.486 23.00248.8481.000 10.94ANISOU 1787 CB PHE 263 1282 1055 1821 -50-253 4ATOM1788 CG PHE 263 6.150 23.39947.4181.000 10.35ANISOU 1788 CG PHE 263 779 1231 1921 -5832340ATOM1789 CD1PHE 263 6.858 22.91546.3261.000 9.98ANISOU 1789 CD1PHE 263 766 1183 1841 -26-101 240ATOM1790 CD2PHE 263 5.106 24.27747.1481.000 11.95ANISOU 1790 CD2PHE 263 1229 1261 2052 245-29 261ATOM1791 CE1PHE 263 6.530 23.22945.0191.000 12.49ANISOU 1791 CE1PHE 263 1718 1173 1857 31 -370 136ATOM1792 CE2PHE 263 4.769 24.60145.8361.000 13.12ANISOU 1792 CE2PHE 263 1451 1382 2151 43 -292 353ATOM1793 CZ PHE 263 5.491 24.11244.7621.000 12.42ANISOU 1793 CZ PHE 263 1318 1453 1948 -138 -187 649ATOM1794 C PHE 263 6.636 20.50548.5301.000 8.91ANISOU 1794 C PHE 263 1076 1085 1223 -39-142 24ATOM1795 O PHE 263 7.868 20.40648.5381.000 10.98ANISOU 1795 O PHE 263 1098 1233 1842 -120 -224 -145ATOM1796 N PHE 264 5.856 19.69147.8121.000 9.19ANISOU 1796 N PHE 264 1089 1266 1136 -86-105 -82ATOM1797 CA PHE 264 6.386 18.60246.9911.000 9.64ANISOU 1797 CA PHE 264 1009 1238 1417 -56-60 -126ATOM1798 CB PHE 264 5.483 17.35847.0051.000 9.92ANISOU 1798 CB PHE 264 1209 1201 1359 -78179ATOM1799 CG PHE 264 5.265 16.67348.3361.000 11.22ANISOU 1799 CG PHE 264 1241 1647 1374 -121 3877ATOM1800 CD1PHE 264 6.292 16.23649.1391.000 15.38ANISOU 1800 CD1 PHE 264 1467 2641 1734 -225 -8 873ATOM1801 CD2 PHE 264 3.988 16.43348.8081.000 16.96ANISOU 1801 CD2 PHE 264 1425 3252 1769 -610 -79 958ATOM1802 CE1 PHE 264 6.090 15.59650.3361.000 14.52ANISOU 1802 CE1 PHE 264 1745 2417 1354 162334 452ATOM1803 CE2 PHE 264 3.755 15.79650.0191.000 18.04ANISOU 1803 CE2 PHE 264 1747 3405 1704 -590 -109 1008ATOM1804 CZ PHE 264 4.817 15.35450.7791.000 12.52ANISOU 1804 CZ PHE 264 1772 1536 1449 -57227 334ATOM1805 CPHE 264 6.535 19.03845.5331.000 8.98ANISOU 1805 CPHE 264 1103 919 1392 14381 -92ATOM1806 OPHE 264 5.497 19.36844.9301.000 9.79ANISOU 1806 OPHE 264 991 1190 1540 28 105 103ATOM1807 NLEU 265 7.758 19.03144.9991.000 8.43ANISOU 1807 NLEU 265 992 884 1325 173-180 158ATOM1808 CA LEU 265 7.984 19.22443.5661.000 8.66ANISOU 1808 CA LEU 265 883 1066 1339 63 -33 -76ATOM1809 CB LEU 265 9.309 19.96443.3281.000 10.10ANISOU 1809 CB LEU 265 1179 1188 1469 -225 -220 248ATOM1810 CG LEU 265 9.570 20.35141.8711.000 9.37ANISOU 1810 CG LEU 265 1072 1009 1478 24225129ATOM1811 CD1 LEU 265 8.725 21.52241.4081.000 10.80ANISOU 1811 CD1 LEU 265 1291 1004 1811 181-114 296ATOM1812 CD2 LEU 265 11.048 20.68441.6781.000 10.87ANISOU 1812 CD2 LEU 265 1129 1483 1519 13443146ATOM1813 CLEU 265 7.933 17.84942.8751.000 10.21ANISOU 1813 CLEU 265 932 1188 1760 -6 -38 -302ATOM1814 OLEU 265 8.858 17.04343.0421.000 10.45ANISOU 1814 OLEU 265 1388 969 1612 84 -217 107ATOM1815 NARG 266 6.853 17.53042.1351.000 10.00ANISOU 1815 NARG 266 1325 1069 1404 -120 -222 15ATOM1816 CA ARG 266 6.572 16.19841.6281.000 10.50ANISOU 1816 CA ARG 266 1219 1217 1554 -294 110 -210ATOM1817 CB ARG 266 5.208 15.67542.1241.000 10.56ANISOU 1817 CB ARG 266 978 1460 1574 -168 -103 -105ATOM1818 CG ARG 266 4.965 15.89443.6091.000 11.24ANISOU 1818 CG ARG 266 1337 1373 1563 -40119 206ATOM1819 CD ARG 266 3.668 15.31844.1461.000 11.17ANISOU 1819 CD ARG 266 1113 1567 1564 -17-49 -11ATOM1820 NE ARG 266 2.508 15.87943.4471.000 9.43ANISOU 1820 NE ARG 266 1341 1157 1086 24 -100 -145ATOM1821 CZ ARG 266 1.236 15.50943.6571.000 9.83ANISOU 1821 CZ ARG 266 1245 1194 1294 132-159 -1ATOM1822 NH1 ARG 266 0.961 14.56744.5721.000 11.20ANISOU 1822 NH1 ARG 266 1208 1240 1806 -144 -454 272ATOM1823 NH2 ARG 266 0.225 16.04842.9751.000 11.08ANISOU 1823 NH2 ARG 266 1460 1265 1484 191-283 73ATOM1824 CARG 266 6.601 16.19040.0991.000 10.28ANISOU 1824 CARG 266 1273 1089 1545 -200 -5-167ATOM1825 OARG 266 6.027 17.10939.5191.000 11.05ANISOU 1825 OARG 266 1254 1153 1793 -132 47-64ATOM1826 NPRO 267 7.215 15.16239.4961.000 10.27ANISOU 1826 NPRO 267 1194 1239 1468 -33130 32ATOM1827 CD PRO 267 7.828 13.96340.1091.000 12.36ANISOU 1827 CD PRO 267 1865 1132 1697 -26-529 -192ATOM1828 CA PRO 267 7.304 15.15738.0361.000 10.12ANISOU 1828 CA PRO 267 1278 1095 1472 -129 38-185ATOM1829 CB PRO 267 8.250 13.98637.7671.000 11.83ANISOU 1829 CB PRO 267 1489 1088 1919 -7290-322ATOM1830 CG PRO 267 8.017 13.05338.9131.000 10.72ANISOU 1830 CG PRO 267 960 1356 1755 95 -257 -187ATOM 1831 C PRO267 5.977 14.929 37.3441.000 10.86ANISOU 1831 C PRO267 1330 1226 1570 -252 47-161ATOM 1832 O PRO267 5.030 14.421 37.9341.000 12.03ANISOU 1832 O PRO267 1316 1174 2080 -258 1777ATOM 1833 N ASN268 5.931 15.288 36.0651.000 10.61ANISOU 1833 N ASN268 1216 1146 1670 -70 -86 -129ATOM 1834 CA ASN268 4.810 14.949 35.1981.000 11.20ANISOU 1834 CA ASN268 1285 1349 1622 -167 -43 -229ATOM 1835 CB ASN268 4.954 15.664 33.8461.000 14.02ANISOU 1835 CB ASN268 2160 1410 1756 132 -316 23ATOM 1836 CG ASN268 4.992 17.175 33.9921.000 13.03ANISOU 1836 CG ASN268 1811 1393 1747 189 -355 -88ATOM 1837 OD1 ASN268 4.046 17.748 34.5661.000 16.65ANISOU 1837 OD1 ASN268 1910 1744 2673 292 -1-159ATOM 1838 ND2 ASN268 6.037 17.818 33.4951.000 14.19ANISOU 1838 ND2 ASN268 2505 1372 1516 161 264 -172ATOM 1839 C ASN268 4.705 13.446 34.9681.000 10.88ANISOU 1839 C ASN268 1294 1314 1526 -75 -226 -164ATOM 1840 O ASN268 5.715 12.732 34.9791.000 11.68ANISOU 1840 O ASN268 1534 1439 1464 87-458 -121ATOM 1841 N ALA269 3.484 12.980 34.6881.000 12.22ANISOU 1841 N ALA269 1484 1428 1732 -108 -397 -427ATOM 1842 CA ALA269 3.277 11.547 34.4171.000 12.12ANISOU 1842 CA ALA269 1432 1356 1819 -238 -29 -282ATOM 1843 CB ALA269 1.817 11.310 34.0581.000 12.38ANISOU 1843 CB ALA269 1439 1278 1985 -228 -183 29ATOM 1844 C ALA269 4.125 10.981 33.2831.000 11.26ANISOU 1844 C ALA269 1445 1240 1592 25-280 -141ATOM 1845 0 ALA269 4.493 9.800 33.2631.000 12.53ANISOU 1845 O ALA269 1428 1249 2085 -110 108 -188ATOM 1846 N ASP270 4.438 11.799 32.2761.000 11.47ANISOU 1846 N ASP270 1701 1280 1378 -261 -341 -300ATOM 1847 CA ASP270 5.214 11.378 31.1131.000 11.92ANISOU 1847 CA ASP270 1826 1106 1595 19-183 -156ATOM 1848 CB ASP270 4.760 12.096 29.8501.000 14.13ANISOU 1848 CB ASP270 1733 2038 1597 84111 212ATOM 1849 CG ASP270 5.050 13.568 29.7771.000 15.98ANISOU 1849 CG ASP270 2309 1939 1823 418 -418 564ATOM 1850 OD1 ASP270 5.432 14.186 30.7621.000 21.61ANISOU 1850 OD1 ASP270 4101 1797 2312 176 -515 163ATOM 1851 OD2 ASP270 4.880 14.152 28.6741.000 24.64ANISOU 1851 OD2 ASP270 3995 3221 2145 -62 -169 1395ATOM 1852 C ASP270 6.721 11.542 31.2641.000 12.86ANISOU 1852 C ASP270 1840 1392 1654 -398 -61 315ATOM 1853 O ASP270 7.443 11.290 30.2921.000 14.83ANISOU 1853 O ASP270 1813 2114 1709 -346 -141 49ATOM 1854 N PHE271 7.230 11.911 32.4391.000 11.85ANISOU 1854 N PHE271 1360 1316 1824 59-25 70ATOM 1855 CA PHE271 8.665 11.927 32.7151.000 11.14ANISOU 1855 CA PHE271 1242 1349 1641 10230 162ATOM 1856 CB PHE271 8.972 12.378 34.1431.000 12.19ANISOU 1856 CB PHE271 1467 1444 1722 -96 -3182ATOM 1857 CG PHE271 10.385 11.992 34.5971.000 12.77ANISOU 1857 CG PHE271 1411 1640 1800 423156ATOM 1858 CD1 PHE271 11.475 12.488 33.9041.000 13.22ANISOU 1858 CD1 PHE271 1513 1516 1993 168 220 49ATOM 1859 CD2 PHE271 10.624 11.155 35.6661.000 13.55ANISOU 1859 CD2 PHE271 1343 1674 2131 139 84255ATOM 1860 CE1 PHE271 12.779 12.178 34.2491.000 14.26ANISOU 1860 CE1 PHE271 1432 1760 2225 -39 46-416ATOM 1861 CE2 PHE271 11.925 10.806 36.0191.000 15.88ANISOU 1861 CE2 PHE 271 15371818 2679 -263 -675 260ATOM1862 CZ PHE 271 13.006 11.28835.3041.000 14.15ANISOU 1862 CZ PHE 271 11661736 2475 7 -531 -467ATOM1863 CPHE 271 9.259 10.55032.4101.000 11.27ANISOU 1863 CPHE 271 13591338 1585 75 271 348ATOM1864 OPHE 271 8.785 9.531 32.9201.000 12.97ANISOU 1864 OPHE 271 20111320 1596 -85473 279ATOM1865 NTHR 272 10.261 10.49831.5411.000 11.95ANISOU 1865 NTHR 272 10181503 2020 -214 300 -115ATOM1866 CA THR 272 10.823 9.254 30.9921.000 12.70ANISOU 1866 CA THR 272 16151557 1652 132341 146ATOM1867 CB THR 272 10.679 9.281 29.4501.000 16.79ANISOU 1867 CB THR 272 18142829 1737 -595 157 -406ATOM1868 OG1 THR 272 9.301 9.471 29.0901.000 18.02ANISOU 1868 OG1 THR 272 19122921 2013 -497 -73 91ATOM1869 CG2 THR 272 11.200 7.976 28.8561.000 17.02ANISOU 1869 CG2 THR 272 21442857 1467 -475 538 -194ATOM1870 CTHR 272 12.272 9.057 31.4231.000 12.02ANISOU 1870 CTHR 272 14361573 1559 92 603 137ATOM1871 OTHR 272 13.055 10.03131.4371.000 14.17ANISOU 1871 OTHR 272 14511583 2351 125602 412ATOM1872 NPHE 273 12.625 7.837 31.8281.000 12.34ANISOU 1872 NPHE 273 14021585 1703 17 378 158ATOM1873 CA PHE 273 13.953 7.492 32.3121.000 12.20ANISOU 1873 CA PHE 273 13621364 1909 -126 336 147ATOM1874 CB PHE 273 13.951 7.514 33.8611.000 12.37ANISOU 1874 CB PHE 273 13621447 1890 -102 211 -8ATOM1875 CG PHE 273 12.988 6.528 34.4911.000 11.65ANISOU 1875 CG PHE 273 13981631 1396 -367 42-215ATOM1876 CD1 PHE 273 11.684 6.889 34.7731.000 14.11ANISOU 1876 CD1 PHE 273 15312214 1614 -336 293 -62ATOM1877 CD2 PHE 273 13.409 5.245 34.8031.000 13.20ANISOU 1877 CD2 PHE 273 20241639 1352 -358 339 -9ATOM1878 CE1 PHE 273 10.793 5.993 35.3231.000 13.25ANISOU 1878 CE1 PHE 273 15362081 1418 -98447 42ATOM1879 CE2 PHE 273 12.530 4.329 35.3271.000 13.39ANISOU 1879 CE2 PHE 273 15291905 1654 -224 140 283ATOM1880 CZ PHE 273 11.227 4.706 35.6041.000 14.75ANISOU 1880 CZ PHE 273 14442260 1902 -90-186 275ATOM1881 CPHE 273 14.423 6.135 31.7951.000 12.45ANISOU 1881 CPHE 273 12781526 1927 -120 317 -31ATOM1882 OPHE 273 13.645 5.311 31.2911.000 11.95ANISOU 1882 OPHE 273 15901580 1370 -137 226 -13ATOM1883 NSER 274 15.717 5.854 31.9521.000 12.07ANISOU 1883 NSER 274 12701640 1677 -29558 353ATOM1884 CA SER 274 16.335 4.586 31.6041.000 14.39ANISOU 1884 CA SER 274 15831534 2349 43 707 384ATOM1885 CB SER 274 17.845 4.771 31.4381.000 14.49ANISOU 1885 CB SER 274 15781727 2202 213695 329ATOM1886 OG SER 274 18.564 3.558 31.4241.000 14.97ANISOU 1886 OG SER 274 17631848 2078 349348 -13ATOM1887 CSER 274 16.100 3.505 32.6661.000 13.12ANISOU 1887 CSER 274 16701481 1833 8 461 137ATOM1888 OSER 274 16.438 3.700 33.8341.000 13.50ANISOU 1888 OSER 274 14931518 2116 -65119 15ATOM1889 NVAL 275 15.533 2.359 32.2711.000 11.90ANISOU 1889 NVAL 275 14761618 1427 -110 490 195ATOM1890 CA VAL 275 15.283 1.254 33.1801.000 11.41ANISOU 1890 CA VAL 275 17081424 1204 -8 286 76ATOM1891 CB VAL 275 14.346 0.198 32.5431.000 12.74ANISOU 1891 CB VAL 275 17321300 1809 62 164 -16ATOM1892 CG1VAL 275 14.157 -1.02033.4371.000 16.10ANISOU 1892 CG1VAL 275 23521803 1962 -614 -663 370ATOM1893 CG2VAL 275 12.961 0.763 32.2611.000 13.81ANISOU 1893 CG2VAL 275 15351786 1924 16 363 126ATOM1894 C VAL 275 16.577 0.622 33.6921.000 12.62ANISOU 1894 C VAL 275 15741628 1594 14 375 136ATOM1895 O VAL 275 16.729 0.405 34.9261.000 13.01ANISOU 1895 O VAL 275 16671643 1634 9 118 180ATOM1896 N PRO 276 17.569 0.286 32.8891.000 14.64ANISOU 1896 N PRO 276 15832066 1914 2 454 -42ATOM1897 CD PRO 276 17.583 0.285 31.4151.000 15.84ANISOU 1897 CD PRO 276 15652536 1916 89 755 35ATOM1898 CA PRO 276 18.827 -0.25033.4531.000 16.76ANISOU 1898 CA PRO 276 16672403 2296 261393 -163ATOM1899 CB PRO 276 19.732 -0.50332.2361.000 18.27ANISOU 1899 CB PRO 276 18042568 2571 411574 -142ATOM1900 CG PRO 276 18.868 -0.38531.0291.000 18.96ANISOU 1900 CG PRO 276 21472763 2293 725694 -37ATOM1901 C PRO 276 19.500 0.710 34.4201.000 16.32ANISOU 1901 C PRO 276 15212342 2336 115237 67ATOM1902 O PRO 276 20.035 0.277 35.4561.000 16.78ANISOU 1902 O PRO 276 14112689 2275 93 376 253ATOM1903 N LEU 277 19.475 2.019 34.1551.000 16.58ANISOU 1903 N LEU 277 18352412 2052 -15483 148ATOM1904 CA LEU 277 20.142 2.919 35.0991.000 17.70ANISOU 1904 CA LEU 277 19902226 2511 -21362 118ATOM1905 CB LEU 277 20.298 4.277 34.4251.000 20.20ANISOU 1905 CB LEU 277 29522292 2432 -1 -14 271ATOM1906 CG LEU 277 21.048 5.359 35.1861.000 20.86ANISOU 1906 CG LEU 277 22132221 3490 -32-355 482ATOM1907 CD1LEU 277 22.446 4.888 35.5311.000 34.24ANISOU 1907 CD1LEU 277 21572303 8552 69 -842 258ATOM1908 CD2LEU 277 21.062 6.620 34.3341.000 31.91ANISOU 1908 CD2LEU 277 47452460 4918 -474 -572 1150ATOM1909 C LEU 277 19.411 2.989 36.4301.000 16.55ANISOU 1909 C LEU 277 19751885 2430 -218 211 -243ATOM1910 O LEU 277 19.997 3.116 37.5171.000 19.19ANISOU 1910 O LEU 277 21792636 2476 -617 50122ATOM1911 N ALA 278 18.080 2.905 36.3861.000 15.48ANISOU 1911 N ALA 278 20081904 1969 -358 279 112ATOM1912 CA ALA 278 17.308 2.896 37.6361.000 14.51ANISOU 1912 CA ALA 278 21091763 1641 -309 74167ATOM1913 CB ALA 278 15.814 2.896 37.3471.000 15.41ANISOU 1913 CB ALA 278 20171773 2064 66 301 626ATOM1914 C ALA 278 17.710 1.684 38.4791.000 14.55ANISOU 1914 C ALA 278 19721869 1689 -195 -255 79ATOM1915 O ALA 278 17.894 1.770 39.6831.000 13.80ANISOU 1915 O ALA 278 14442144 1655 -250 -166 89ATOM1916 N ARG 279 17.841 0.530 37.8421.000 13.86ANISOU 1916 N ARG 279 17951728 1742 -432 -128 169ATOM1917 CA ARG 279 18.242 -0.67938.5601.000 15.88ANISOU 1917 CA ARG 279 19951973 2064 59 355 411ATOM1918 CB ARG 279 18.204 -1.92237.6481.000 16.83ANISOU 1918 CB ARG 279 18891897 2609 84 544 250ATOM1919 CG ARG 279 16.790 -2.32337.2911.000 19.63ANISOU 1919 CG ARG 279 21232196 3139 -63233 91ATOM1920 CD ARG 279 16.656 -3.28836.1311.000 27.03ANISOU 1920 CD ARG 279 39243198 3150 -603 -275 -198ATOM1921 NE ARG 279 17.236 -4.57836.3641.000 27.45ANISOU 1921 NE ARG 279 46592854 2915 -359 751 -789ATOM1922 CZ ARG 279 16.714 -5.71736.7791.000 32.85ANISOU 1922 CZARG279 4486 3045 4948 -475 448 -222ATOM1923 NH1 ARG279 15.424-5.87437.0891.000 29.96ANISOU 1923 NH1 ARG279 4653 2168 4562 -103 967 -678ATOM1924 NH2 ARG279 17.551-6.75036.8901.000 37.87ANISOU 1924 NH2 ARG279 4879 2436 7074 -276 3278 -824ATOM1925 C ARG279 19.628-0.51939.1501.000 17.48ANISOU 1925 C ARG279 2118 1653 2871 75 -8705ATOM1926 O ARG279 19.916-1.06440.2121.000 26.82ANISOU 1926 O ARG279 3764 3102 3325 -1987 -1467 1383ATOM1927 N GLU280 20.5380.189 38.5051.000 17.73ANISOU 1927 N GLU280 1983 2293 2459 109609 37ATOM1928 CAGLU280 21.8990.317 39.0261.000 19.66ANISOU 1928 CAGLU280 2049 2023 3396 125215 737ATOM1929 CBGLU280 22.8360.886 37.9361.000 20.17ANISOU 1929 CBGLU280 1648 2457 3560 464138 1099ATOM1930 CGGLU280 22.964-0.14936.8181.000 31.79ANISOU 1930 CGGLU280 3477 4175 4427 8011187 -4ATOM1931 CDGLU280 23.6980.341 35.5901.000 39.66ANISOU 1931 CDGLU280 5144 5703 4221 -641339 -6ATOM1932 OE1 GLU280 24.4661.327 35.6851.000 39.65ANISOU 1932 OE1 GLU280 3464 5891 5710 334574 1639ATOM1933 OE2 GLU280 23.489-0.29434.5191.000 41.55ANISOU 1933 OE2 GLU280 5257 6747 3781 2245 -184 102ATOM1934 C GLU280 21.9841.188 40.2661.000 19.68ANISOU 1934 C GLU280 1488 2350 3640 -566 162 490ATOM1935 O GLU280 23.0311.142 40.9581.000 25.69ANISOU 1935 O GLU280 1871 3766 4123 231-245 180ATOM1936 N CYS281 20.9431.980 40.5651.000 18.57ANISOU 1936 N CYS281 1560 2609 2887 -406 -211 176ATOM1937 CACYS281 21.0982.762 41.8061.000 23.83ANISOU 1937 CACYS281 3222 2647 3184 -1189 176 -122ATOM1938 CBCYS281 21.0794.264 41.5231.000 25.40ANISOU 1938 CBCYS281 3278 2655 3718 -426 368 -46ATOM1939 SGCYS281 19.5874.904 40.7631.000 27.05ANISOU 1939 SGCYS281 3069 2914 4295 -522 -37 -794ATOM1940 C CYS281 20.0982.406 42.9071.000 16.99ANISOU 1940 C CYS281 1377 1604 3475 109-6-546ATOM1941 O CYS281 19.9713.173 43.8891.000 17.04ANISOU 1941 O CYS281 2294 1277 2902 -204 -484 -129ATOM1942 N GLY282 19.4471.245 42.7941.000 15.23ANISOU 1942 N GLY282 1617 1597 2572 3 -58 -436ATOM1943 CAGLY282 18.7310.674 43.9141.000 15.61ANISOU 1943 CAGLY282 1565 1973 2394 6 -331 -266ATOM1944 C GLY282 17.2460.519 43.7271.000 13.75ANISOU 1944 C GLY282 1635 1562 2029 -270 -446 -78ATOM1945 O GLY282 16.5850.012 44.6391.000 14.99ANISOU 1945 O GLY282 1751 1630 2313 207-242 455ATOM1946 N PHE283 16.7441.009 42.5821.000 12.65ANISOU 1946 N PHE283 1434 1803 1570 -200 18-252ATOM1947 CAPHE283 15.2920.886 42.3741.000 11.80ANISOU 1947 CAPHE283 1477 1032 1974 -15-264 46ATOM1948 CBPHE283 14.8391.890 41.2951.000 14.13ANIS0U 1948 CBPHE283 2262 972 2136 109-187 159ATOM1949 CGPHE283 14.9063.351 41.7571.000 12.63ANISOU 1949 CGPHE283 1711 1033 2055 47 -86 9ATOM1950 CD1 PHE283 13.8513.928 42.4091.000 13.45ANISOU 1950 CD1 PHE283 1697 1399 2013 -166 24-229ATOM1951 CD2 PHE283 16.0374.111 41.5191.000 13.15ANISOU 1951 CD2 PHE283 1567 1135 2295 142-41 -99ATOM1952 CE1 PHE283 13.9035.248 42.8391.000 15.61ANISOU 1952 CE1 PHE283 2111 1649 2171 -202 484 -617ATOM 1953 CE2 PHE283 16.1125.432 41.963 1.000 12.60ANISOU 1953 CE2 PHE283 1783 9372068 32-18 264ATOM 1954 CZ PHE283 15.0405.993 42.641 1.000 13.37ANISOU 1954 CZ PHE283 1863 8652352 187 -149 13ATOM 1955 CPHE283 14.915-0.534 41.972 1.000 11.23ANISOU 1955 CPHE283 1527 9741765 63-172 65ATOM 1956 OPHE283 15.471-1.071 40. 990 1.000 13.24ANISOU 1956 OPHE283 1249 1428 2355 175 -120 -361ATOM 1957 NASP284 13.998-1.130 42.712 1.000 12.31ANISOU 1957 NASP284 1607 1333 1736 -268 -312 87ATOM 1958 CA ASP284 13.589-2.528 42.527 1.000 12.48ANISOU 1958 CA ASP284 1725 1202 1814 -148 -543 350ATOM 1959 CB ASP284 13.159-3.156 43.876 1.000 12.67ANISOU 1959 CB ASP284 2014 1145 1656 -50 -406 135ATOM 1960 CG ASP284 13.261-4.667 43.909 1.000 13.40ANISOU 1960 CG ASP284 2077 1171 1843 110 -419 363ATOM 1961 OD1 ASP284 13.861-5.246 42.974 1.000 14.98ANISOU 1961 OD1 ASP284 1956 1094 2640 -87 1160ATOM 1962 OD2 ASP284 12.762-5.306 44.883 1.000 15.79ANISOU 1962 OD2 ASP284 2494 1539 1966 -330 -446 438ATOM 1963 CASP284 12.478-2.641 41.510 1.000 10.82ANISOU 1963 CASP284 1238 1387 1487 -205 -99 123ATOM 1964 OASP284 11.373-3.100 41.777 1.000 12.28ANISOU 1964 OASP284 1331 1175 2159 -209 48191ATOM 1965 NVAL285 12.751-2.154 40.308 1.000 11.32ANISOU 1965 NVAL285 1204 1671 1426 -93 -48 61ATOM 1966 CA VAL285 11.748-2.062 39.260 1.000 11.45ANISOU 1966 CA VAL285 1468 1384 1500 39-219 -15ATOM 1967 CB VAL285 12.153-1.072 38.157 1.000 11.58ANISOU 1967 CB VAL285 1412 1523 1465 -388 -428 -8ATOM 1968 CG1 VAL285 12.2780.362 38.679 1.000 15.02ANISOU 1968 CG1 VAL285 2209 1458 2040 -264 -442 -32ATOM 1969 CG2 VAL285 13.467-1.482 37.495 1.000 15.70ANISOU 1969 CG2 VAL285 1909 1443 2615 -159 309 447ATOM 1970 CVAL285 11.424-3.431 38.642 1.000 10.83ANISOU 1970 CVAL285 1232 1281 1602 93-221 108ATOM 1971 OVAL285 12.267-4.301 38.520 1.000 12.13ANISOU 1971 OVAL285 1214 1192 2202 -28 300 162ATOM 1972 NSER286 10.168-3.523 38.248 1.000 11.09ANISOU 1972 NSER286 1116 1608 1489 -76 967ATOM 1973 CA SER286 9.558 -4.622 37.510 1.000 11.32ANISOU 1973 CA SER286 1104 1479 1718 -41 -274 252ATOM 1974 CB SER286 8.483 -5.292 38.344 1.000 9.88ANISOU 1974 CB SER286 1328 1141 1285 72-207 70ATOM 1975 OG SER286 7.570 -4.361 38.905 1.000 11.34ANISOU 1975 OG SER286 1391 1188 1729 147 -153 75ATOM 1976 CSER286 9.019 -4.106 36.175 1.000 10.34ANISOU 1976 CSER286 1127 1227 1575 28-87 245ATOM 1977 OSER286 7.829 -4.112 35.869 1.000 12.62ANISOU 1977 OSER286 1223 2219 1353 0 -178 228ATOM 1978 NLEU287 9.926 -3.622 35.335 1.000 12.45ANISOU 1978 NLEU287 1414 1664 1653 -212 3 161ATOM 1979 CA LEU287 9.654 -2.900 34.099 1.000 12.59ANISOU 1979 CA LEU287 1622 1558 1605 -366 94184ATOM 1980 CB LEU287 10.145-1.452 34.210 1.000 12.91ANISOU 1980 CB LEU287 1716 1591 1597 -373 -95 27ATOM 1981 CG LEU287 9.452 -0.590 35.264 1.000 12.96ANISOU 1981 CG LEU287 1182 1848 1895 -407 -51 -170ATOM 1982 CD1 LEU287 10.2290.708 35.484 1.000 13.34ANISOU 1982 CD1 LEU287 1644 1108 2318 -38 -124 223ATOM 1983 CD2 LEU287 8.006 -0.248 34.914 1.000 14.56ANISOU 1983 CD2 LEU 287 17161548 2267 36-550 318ATOM1984 CLEU 287 10.319 -3.61032.9281.000 12.63ANISOU 1984 CLEU 287 18371244 1719 -233 248 354ATOM1985 OLEU 287 11.529 -3.80532.9161.000 16.68ANISOU 1985 OLEU 287 17791998 2560 -292 390 -149ATOM1986 NASP 288 9.531 -4.04531.9501.000 13.91ANISOU 1986 NASP 288 20801751 1455 4 223 227ATOM1987 CA ASP 288 10.079 -4.68830.7591.000 15.50ANISOU 1987 CA ASP 288 20292269 1593 -122 605 153ATOM1988 CB ASP 288 8.979 -5.47830.0431.000 17.00ANISOU 1988 CB ASP 288 27222125 1613 -250 362 -2ATOM1989 CG ASP 288 9.480 -6.45229.0141.000 19.30ANISOU 1989 CG ASP 288 24672980 1885 173 243 -377ATOM1990 OD1 ASP 288 10.447 -7.18329.2921.000 25.95ANISOU 1990 OD1 ASP 288 28123190 3856 501 -239 -783ATOM1991 OD2 ASP 288 8.911 -6.50827.9071.000 31.76ANISOU 1991 OD2 ASP 288 53754430 2260 1266 -849 -1154ATOM1992 CASP 288 10.654 -3.65229.8111.000 17.08ANISOU 1992 CASP 288 22592631 1602 -263 248 534ATOM1993 OASP 288 10.197 -2.50229.7081.000 23.31ANISOU 1993 OASP 288 42762268 2313 -244 -13 297ATOM1994 NGLY 289 11.702 -3.96629.0491.000 21.26ANISOU 1994 NGLY 289 27483699 1632 -610 752 511ATOM1995 CA GLY 289 12.116 -2.88028.1521.000 21.65ANISOU 1995 CA GLY 289 28423988 1396 -1163 71626ATOM1996 CGLY 289 13.084 -1.85928.7361.000 22.09ANISOU 1996 CGLY 289 28883509 1996 -738 -23 243ATOM1997 OGLY 289 13.414 -1.83629.9241.000 20.34ANISOU 1997 OGLY 289 32302606 1891 -918 124 147ATOM1998 NGLU 290 13.562 -0.95227.8691.000 16.48ANISOU 1998 NGLU 290 26652099 1496 5 222 -445ATOM1999 CA GLU 290 14.716 -0.11728.1821.000 16.94ANISOU 1999 CA GLU 290 24702161 1806 81411 -484ATOM2000 CB GLU 290 15.579 0.012 26.9121.000 20.26ANISOU 2000 CB GLU 290 26702740 2287 414 863 -239ATOM2001 CG GLU 290 16.071 -1.33326.3861.000 24.53ANISOU 2001 CG GLU 290 32513153 2916 664 1218 -612ATOM2002 CD GLU 290 16.812 -2.17027.4111.000 27.91ANISOU 2002 CD GLU 290 30193161 4424 989 940 -251ATOM2003 OE1 GLU 290 17.874 -1.74727.9171.000 35.13ANISOU 2003 OE1 GLU 290 39134458 4975 963 -85 -877ATOM2004 OE2 GLU 290 16.336 -3.28027.7341.000 43.76ANISOU 2004 OE2 GLU 290 68933257 6478 -30 -748 598ATOM2005 CGLU 290 14.406 1.271 28.7161.000 14.67ANISOU 2005 CGLU 290 25121756 1308 95142 10ATOM2006 OGLU 290 15.260 1.840 29.4121.000 15.25ANISOU 2006 OGLU 290 20741969 1750 50418 -262ATOM2007 NTHR 291 13.232 1.814 28.4371.000 15.72ANISOU 2007 NTHR 291 21732393 1406 78346 -519ATOM2008 CA THR 291 12.792 3.087 28.9911.000 15.16ANISOU 2008 CA THR 291 20801845 1833 -88 631 -15ATOM2009 CB THR 291 12.766 4.226 27.9561.000 18.67ANISOU 2009 CB THR 291 27242529 1842 -361 769 336ATOM2010 OG1 THR 291 11.756 4.009 26.9761.000 22.93ANISOU 2010 OG1 THR 291 33133135 2265 445 78146ATOM2011 CG2 THR 291 14.096 4.306 27.2131.000 21.82ANISOU 2011 CG2 THR 291 30352126 3130 357 1450 902ATOM2012 CTHR 291 11.402 2.920 29.6221.000 12.86ANISOU 2012 CTHR 291 18631604 1421 47305 219ATOM2013 OTHR 291 10.625 2.024 29.2701.000 16.13ANISOU 2013 OTHR 291 23441983 1804 -303 750 -431ATOM2014 NALA 292 11.037 3.791 30.5421.000 12.41ANISOU 2014 NALA 292 149513631859 -2 256 77ATOM2015 CA ALA 292 9.746 3.839 31.2021.000 11.57ANISOU 2015 CA ALA 292 136212571779 -213 153 37ATOM2016 CB ALA 292 9.718 2.954 32.4391.000 12.62ANISOU 2016 CB ALA 292 176812451784 100357 4ATOM2017 CALA 292 9.385 5.255 31.6141.000 10.32ANISOU 2017 CALA 292 131713351270 -181 9954ATOM2018 OALA 292 10.266 6.134 31.7011.000 10.97ANISOU 2018 OALA 292 138911381641 -146 279 104ATOM2019 NTHR 293 8.091 5.445 31.8821.000 12.32ANISOU 2019 NTHR 293 148615471647 -314 563 -284ATOM2020 CA THR 293 7.626 6.715 32.4211.000 12.28ANISOU 2020 CA THR 293 171714601489 -168 337 -200ATOM2021 CB THR 293 6.352 7.215 31.7331.000 13.27ANISOU 2021 CB THR 293 212811821730 -258 -159 -284ATOM2022 OG1 THR 293 5.317 6.237 31.9111.000 13.85ANISOU 2022 OG1 THR 293 183112172216 8 -131 74ATOM2023 CG2 THR 293 6.474 7.303 30.2121.000 13.72ANISOU 2023 CG2 THR 293 179116831738 -252 -56 -405ATOM2024 CTHR 293 7.363 6.635 33.9371.000 10.58ANISOU 2024 CTHR 293 143910501533 12 447 9ATOM2025 OTHR 293 7.211 5.576 34.5531.000 10.29ANISOU 2025 OTHR 293 104911021758 -5693118ATOM2026 NPHE 294 7.243 7.810 34.5691.000 11.53ANISOU 2026 NPHE 294 179410931494 -307 306 -66ATOM2027 CA PHE 294 6.806 7.939 35.9501.000 10.41ANISOU 2027 CA PHE 294 143210611463 -174 125 -162ATOM2028 CB PHE 294 6.709 9.426 36.3361.000 12.25ANISOU 2028 CB PHE 294 193010301694 -164 292 -64ATOM2029 CG PHE 294 6.270 9.658 37.7701.000 12.77ANISOU 2029 CG PHE 294 188011361837 -103 178 -427ATOM2030 CD1 PHE 294 7.123 9.462 38.8391.000 14.73ANISOU 2030 CD1 PHE 294 197618931727 -539 161 -132ATOM2031 CD2 PHE 294 4.989 10.068 38.0561.000 16.59ANISOU 2031 CD2 PHE 294 218019232199 348386 -492ATOM2032 CE1 PHE 294 6.726 9.673 40.1441.000 14.36ANISOU 2032 CE1 PHE 294 159820281830 -505 280 -118ATOM2033 CE2 PHE 294 4.575 10.275 39.3451.000 16.75ANISOU 2033 CE2 PHE 294 221420622087 692144 -602ATOM2034 CZ PHE 294 5.426 10.065 40.4131.000 15.17ANISOU 2034 CZ PHE 294 204014262296 32797-135ATOM2035 CPHE 294 5.484 7.195 36.1721.000 10.89ANISOU 2035 CPHE 294 140112001536 -155 78137ATOM2036 OPHE 294 5.325 6.425 37.1251.000 10.67ANISOU 2036 OPHE 294 139612971360 90 337 105ATOM2037 NGLN 295 4.487 7.355 35.2991.000 10.62ANISOU 2037 NGLN 295 139911871450 -1888-24ATOM2038 CA GLN 295 3.217 6.612 35.3931.000 11.31ANISOU 2038 CA GLN 295 143312051660 -96120 -321ATOM2039 CB GLN 295 2.284 7.053 34.2541.000 11.66ANISOU 2039 CB GLN 295 142510531953 -2563-141ATOM2040 CG GLN 295 0.951 6.360 34.2001.000 11.05ANISOU 2040 CG GLN 295 157310111614 -93-118 18ATOM2041 CD GLN 295 0.052 6.843 33.0871.000 11.35ANISOU 2041 CD GLN 295 159213261395 17357-13ATOM2042 OE1 GLN 295 0.349 7.823 32.3781.000 15.06ANISOU 2042 OE1 GLN 295 230615891825 1107 379ATOM2043 NE2 GLN 295 -1.053 6.153 32.9141.000 13.90ANISOU 2043 NE2 GLN 295 151117572015 156-282 208ATOM2044 CGLN 295 3.412 5.107 35.3891.000 10.12ANISOU 2044 CGLN 295 1154 1203 1486 21 160 -191ATOM2045 OGLN 295 2.827 4.309 36.1281.000 11.82ANISOU 2045 OGLN 295 1264 1542 1686 -10741137ATOM2046 NASP 296 4.267 4.558 34.5381.000 9.35ANISOU 2046 NASP 296 1076 1056 1422 -118-76 -275ATOM2047 CA ASP 296 4.655 3.172 34.4161.000 9.91ANISOU 2047 CA ASP 296 1241 1139 1387 56 60-243ATOM2048 CB ASP 296 5.699 2.852 33.3471.000 10.26ANISOU 2048 CB ASP 296 1315 1156 1429 113 132 -36ATOM2049 CG ASP 296 5.343 2.981 31.8851.000 11.42ANISOU 2049 CG ASP 296 1357 1578 1405 358 121 -199ATOM2050 OD1 ASP 296 4.143 2.904 31.5311.000 13.82ANISOU 2050 OD1 ASP 296 1511 1744 1997 149 -209 -62ATOM2051 OD2 ASP 296 6.282 3.151 31.0471.000 13.48ANISOU 2051 OD2 ASP 296 1802 1758 1564 228 364 73ATOM2052 CASP 296 5.175 2.682 35.7701.000 10.31ANISOU 2052 CASP 296 1416 1141 1361 16 91-198ATOM2053 OASP 296 4.852 1.551 36.1971.000 11.40ANISOU 2053 OASP 296 1428 1452 1453 -2883235ATOM2054 NTRP 297 6.004 3.484 36.4411.000 10.88ANISOU 2054 NTRP 297 1752 1144 1238 -1611155ATOM2055 CA TRP 297 6.646 3.104 37.6851.000 11.26ANISOU 2055 CA TRP 297 1768 1215 1294 -217-57 45ATOM2056 CB TRP 297 7.899 3.999 37.8901.000 10.31ANISOU 2056 CB TRP 297 1387 1417 1112 -87 213 120ATOM2057 CG TRP 297 8.621 3.651 39.1721.000 10.98ANISOU 2057 CG TRP 297 1456 1394 1324 164 -29 -43ATOM2058 CD2 TRP 297 9.082 4.534 40.2021.000 12.49ANISOU 2058 CD2 TRP 297 1255 1729 1761 75 -298 -197ATOM2059 CE2 TRP 297 9.692 3.755 41.2011.000 16.08ANISOU 2059 CE2 TRP 297 1860 2049 2202 -294-977 49ATOM2060 CE3 TRP 297 9.040 5.910 40.3791.000 17.41ANISOU 2060 CE3 TRP 297 2778 1740 2096 -388-916 -234ATOM2061 CD1 TRP 297 8.969 2.400 39.5891.000 13.58ANISOU 2061 CD1 TRP 297 1617 1518 2025 0 -664 114ATOM2062 NE1 TRP 297 9.614 2.444 40.8081.000 16.12ANISOU 2062 NE1 TRP 297 2165 1909 2051 -22 -873 220ATOM2063 CZ2 TRP 297 10.243 4.320 42.3411.000 19.85ANISOU 2063 CZ2 TRP 297 2756 2383 2404 -951-1337 267ATOM2064 CZ3 TRP 297 9.586 6.466 41.5151.000 23.40ANISOU 2064 CZ3 TRP 297 4215 2030 2645 -1001 -1757 -77ATOM2065 CH2 TRP 297 10.181 5.670 42.4861.000 21.51ANISOU 2065 CH2 TRP 297 3178 2457 2537 -910-1473 -51ATOM2066 CTRP 297 5.700 3.138 38.8821.000 10.39ANISOU 2066 CTRP 297 1172 1448 1329 -280-237 391ATOM2067 OTRP 297 5.574 2.159 39.6391.000 13.52ANISOU 2067 OTRP 297 1748 1830 1557 32 -91 703ATOM2068 NILE 298 5.033 4.272 39.0791.000 12.08ANISOU 2068 NILE 298 1400 1710 1480 -49 83451ATOM2069 CA ILE 298 4.223 4.521 40.2721.000 13.43ANISOU 2069 CA ILE 298 1301 2484 1317 -199-158 -33ATOM2070 CB ILE 298 4.370 5.988 40.6891.000 16.97ANISOU 2070 CB ILE 298 1877 2908 1661 -1000 214 -630ATOM2071 CG2 ILE 298 3.538 6.423 41.8761.000 22.01ANISOU 2071 CG2 ILE 298 3980 3121 1263 -233546 -339ATOM2072 CG1 ILE 298 5.847 6.253 41.0371.000 27.10ANISOU 2072 CG1 ILE 298 2588 5151 2557 -2140 -708 97ATOM2073 CD1 ILE 298 6.365 5.522 42.2661.000 43.13ANISOU 2073 CD1 ILE 298 5185 8299 2904 -3717 -3055 708ATOM2074 CILE 298 2.772 4.116 40.1311.000 10.94ANISOU 2074 CILE 298 1350 1652 1156 -165-79 96ATOM2075 O ILE 298 2.137 3.844 41.155 1.000 12.67ANISOU 2075 O ILE 298 16891634 1493 -102 212 352ATOM2076 N GLY 299 2.267 4.077 38.897 1.000 10.14ANISOU 2076 N GLY 299 14121057 1384 -51-377 201ATOM2077 CAGLY 299 0.866 3.822 38.695 1.000 10.72ANISOU 2077 CAGLY 299 13351084 1655 0 -229 -206ATOM2078 C GLY 299 0.049 5.054 38.369 1.000 12.05ANISOU 2078 C GLY 299 14221293 1864 105-292 0ATOM2079 O GLY 299 0.585 6.088 37.976 1.000 13.11ANISOU 2079 O GLY 299 19171199 1866 17480-23ATOM2080 N GLY 300 -1.268 4.931 38.490 1.000 13.92ANISOU 2080 N GLY 300 13931531 2363 182-410 -223ATOM2081 CAGLY 300 -2.237 5.932 38.087 1.000 14.02ANISOU 2081 CAGLY 300 15241471 2331 217-563 -336ATOM2082 C GLY 300 -2.587 7.015 39.074 1.000 11.97ANISOU 2082 C GLY 300 940 1603 2004 67 -488 -295ATOM2083 O GLY 300 -3.322 7.950 38.722 1.000 10.90ANISOU 2083 O GLY 300 12191408 1515 -37-203 -134ATOM2084 N ASN 301 -2.090 6.910 40.285 1.000 11.64ANISOU 2084 N ASN 301 948 1557 1917 -383 -327 165ATOM2085 CAASN 301 -2.195 7.915 41.323 1.000 13.39ANISOU 2085 CAASN 301 16261904 1557 -191 -403 183ATOM2086 CBASN 301 -3.047 7.301 42.427 1.000 17.60ANISOU 2086 CBASN 301 13912869 2426 -9 326 228ATOM2087 CGASN 301 -4.021 8.196 43.108 1.000 19.15ANISOU 2087 CGASN 301 25492827 1900 80559377ATOM2088 OD1 ASN 301 -5.072 8.606 42.591 1.000 15.47ANISOU 2088 OD1 ASN 301 12582340 2280 -253 339 -8ATOM2089 ND2 ASN 301 -3.661 8.510 44.367 1.000 29.28ANISOU 2089 ND2 ASN 301 35854783 2758 1521 -850 -885ATOM2090 C ASN 301 -0.862 8.331 41.914 1.000 11.31ANISOU 2090 C ASN 301 14361669 1194 1 1 -168ATOM2091 O ASN 301 -0.033 7.456 42.221 1.000 12.03ANISOU 2091 O ASN 301 14831548 1542 -151 -279 82ATOM2092 N TYR 302 -0.634 9.628 42.133 1.000 11.53ANISOU 2092 N TYR 302 11861584 1611 -6126102ATOM2093 CATYR 302 0.573 10.04642.838 1.000 11.90ANISOU 2093 CATYR 302 12601395 1865 5 -212 225ATOM2094 CBTYR 302 0.657 11.58943.036 1.000 13.14ANISOU 2094 CBTYR 302 17681404 1820 -273 190 181ATOM2095 CGTYR 302 1.082 12.28741.750 1.000 10.88ANISOU 2095 CGTYR 302 13951347 1393 -321 2 -153ATOM2096 CD1 TYR 302 2.421 12.43941.413 1.000 11.29ANISOU 2096 CD1 TYR 302 13851246 1659 -5898-46ATOM2097 CE1 TYR 302 2.859 13.07540.248 1.000 10.60ANISOU 2097 CE1 TYR 302 10551241 1732 -1152-1ATOM2098 CD2 TYR 302 0.161 12.79340.858 1.000 11.30ANISOU 2098 CD2 TYR 302 13041332 1656 -145 105 -26ATOM2099 CE2 TYR 302 0.573 13.40639.690 1.000 11.72ANISOU 2099 CE2 TYR 302 10131733 1708 -288 -138 161ATOM2100 CZTYR 302 1.907 13.55139.375 1.000 10.35ANISOU 2100 CZTYR 302 10091214 1709 -229 -50 -19ATOM2101 OHTYR 302 2.284 14.15338.202 1.000 11.82ANISOU 2101 OHTYR 302 11921532 1766 -8 102 104ATOM2102 C TYR 302 0.654 9.349 44.196 1.000 12.45ANISOU 2102 C TYR 302 15171450 1765 -181 -202 217ATOM2103 O TYR 302 -0.375 9.230 44.878 1.000 13.55ANISOU 2103 O TYR 302 14641925 1759 -339 -211 7ATOM2104 N VAL 303 1.868 8.967 44.542 1.000 12.06ANISOU 2104 N VAL 303 15171653 1413 -135 -3340ATOM2105 CAVAL 303 2.309 8.430 45.820 1.000 11.88ANISOU 2105 CA VAL 303 1434 1609 1471 -368 -197 223ATOM2106 CB VAL 303 2.755 6.967 45.7361.000 14.57ANISOU 2106 CB VAL 303 1395 1682 2459 -217 -918 312ATOM2107 CG1 VAL 303 3.131 6.462 47.1321.000 17.33ANISOU 2107 CG1 VAL 303 2644 1608 2331 -48-1114 61ATOM2108 CG2 VAL 303 1.703 6.041 45.1221.000 14.80ANISOU 2108 CG2 VAL 303 1876 1676 2069 -592 -639 322ATOM2109 CVAL 303 3.467 9.328 46.3031.000 13.88ANISOU 2109 CVAL 303 870 1791 2613 75 -286 -375ATOM2110 OVAL 303 4.526 9.417 45.6811.000 19.70ANISOU 2110 OVAL 303 1064 2307 4114 -61323 -999ATOM2111 NASN 304 3.271 10.046 47.3931.000 13.77ANISOU 2111 NASN 304 1681 1815 1737 -479 -388 140ATOM2112 CA ASN 304 4.205 11.077 47.8281.000 13.37ANISOU 2112 CA ASN 304 1626 1240 2212 -213 -533 279ATOM2113 CB ASN 304 3.460 12.223 48.5661.000 13.24ANISOU 2113 CB ASN 304 1206 1454 2370 -243 -344 296ATOM2114 CG ASN 304 2.457 12.922 47.6671.000 14.16ANISOU 2114 CG ASN 304 1142 2326 1910 146-88 230ATOM2115 OD1 ASN 304 2.776 13.283 46.5401.000 16.65ANISOU 2115 OD1 ASN 304 1408 2456 2464 107185 916ATOM2116 ND2 ASN 304 1.263 13.126 48.2091.000 17.45ANISOU 2116 ND2 ASN 304 1414 2961 2257 545181 315ATOM2117 CASN 304 5.325 10.588 48.7281.000 11.18ANISOU 2117 CASN 304 1382 1299 1566 -183 -163 112ATOM2118 OASN 304 6.396 11.232 48.6991.000 12.07ANISOU 2118 OASN 304 1325 1382 1879 -167 -66 -59ATOM2119 NILE 305 5.092 9.541 49.5161.000 12.56ANISOU 2119 NILE 305 1791 1296 1685 -152 -232 202ATOM2120 CA ILE 305 6.063 9.011 50.4631.000 14.01ANISOU 2120 CA ILE 305 2314 1393 1614 -55-479 79ATOM2121 CB ILE 305 5.781 9.493 51.9061.000 14.44ANISOU 2121 CB ILE 305 2223 1604 1659 -29-217 157ATOM2122 CG2 ILE 305 5.725 11.017 51.9561.000 15.31ANISOU 2122 CG2 ILE 305 1768 1608 2441 43 -479 -314ATOM2123 CG1 ILE 305 4.543 8.853 52.4981.000 14.83ANISOU 2123 CG1 ILE 305 1779 1694 2163 27 -307 -153ATOM2124 CD1 ILE 305 4.163 9.252 53.9001.000 28.68ANISOU 2124 CD1 ILE 305 3788 5324 1786 -1491 381 92ATOM2125 CILE 305 6.059 7.487 50.3891.000 12.79ANISOU 2125 CILE 305 1703 1355 1800 -260 -586 231ATOM2126 OILE 305 5.111 6.864 49.8971.000 15.63ANISOU 2126 OILE 305 1779 1564 2597 -185 -1008 277ATOM2127 NARG 306 7.170 6.896 50.8291.000 13.04ANISOU 2127 NARG 306 1618 1389 1946 -368 -598 383ATOM2128 CA ARG 306 7.340 5.435 50.8681.000 11.82ANISOU 2128 CA ARG 306 1352 1366 1773 -375 -154 444ATOM2129 CB ARG 306 8.111 4.965 49.6401.000 15.28ANISOU 2129 CB ARG 306 1976 1941 1886 -368 -19 111ATOM2130 CG ARG 306 8.203 3.472 49.3951.000 17.16ANISOU 2130 CG ARG 306 2566 1953 2001 -68-68 76ATOM2131 CD ARG 306 8.344 3.075 47.9371.000 19.51ANISOU 2131 CD ARG 306 2921 2361 2130 -397 -396 -302ATOM2132 NE ARG 306 7.078 3.198 47.2121.000 20.65ANISOU 2132 NE ARG 306 2693 2844 2309 -1056 -310 214ATOM2133 CZ ARG 306 6.948 3.186 45.8931.000 17.11ANISOU 2133 CZ ARG 306 2006 2225 2268 45 -91 596ATOM2134 NH1 ARG 306 8.013 3.065 45.0831.000 21.58ANISOU 2134 NH1 ARG 306 2405 2677 3116 -232 381 -669ATOM2135 NH2 ARG 306 5.734 3.301 45.3651.000 17.51ANISOU 2135 NH2 ARG 306 2235 1550 2868 150-484 -162ATOM2136 C ARG306 8.035 5.027 52.1551.000 13.45ANISOU 2136 C ARG306 2254 1018 1837 -246 -481 98ATOM2137 O ARG306 9.006 5.682 52.5561.000 12.15ANISOU 2137 O ARG306 1902 1099 1615 -18-362 -80ATOM2138 N ARG307 7.571 3.968 52.8111.000 18.19ANISOU 2138 N ARG307 3073 1620 2218 -734 -938 792ATOM2139 CA ARG307 8.197 3.380 53.9891.000 19.20ANISOU 2139 CA ARG307 3053 1963 2277 -675 -1236 643ATOM2140 C ARG307 9.086 2.191 53.6111.000 23.08ANISOU 2140 C ARG307 4018 1905 2847 -270 -1885 329ATOM2141 O ARG307 8.636 1.292 52.8951.000 35.93ANISOU 2141 O ARG307 6003 2403 5244 38 -3227 -791ATOM2142 CB ARG307 7.131 2.918 54.9971.000 28.25ANISOU 2142 CB ARG307 5557 3297 1882 -1503 -277 509ATOM2143 CG ARG307 6.032 3.921 55.2751.000 33.39ANISOU 2143 CG ARG307 4564 4859 3261 -1613 731 208ATOM2144 CD ARG307 5.022 3.523 56.3171.000 40.42ANISOU 2144 CD ARG307 6335 5701 3322 -1900 1263 971ATOM2145 NE ARG307 5.605 2.952 57.5291.000 50.83ANISOU 2145 NE ARG307 8119 7287 3908 -2786 105 1624ATOM2146 CZ ARG307 4.894 2.441 58.5301.000 51.36ANISOU 2146 CZ ARG307 7424 8064 4025 -3650 -966 2451ATOM2147 NH1 ARG307 3.567 2.422 58.4851.000 69.51ANISOU 2147 NH1 ARG307 7586 10951 7874 -6970 -2008 3245ATOM2148 NH2 ARG307 5.489 1.937 59.6001.000 59.99ANISOU 2148 NH2 ARG307 107148150 3930 -5986 -3291 2028ATOM2149 N THR308 10.347 2.147 54.0481.000 22.92ANISOU 2149 N THR308 2759 2587 3364 -589 -200 170ATOM2150 CA THR308 11.215 1.009 53.7941.000 24.47ANISOU 2150 CA THR308 3382 2649 3268 -360 52150ATOM2151 C THR308 10.602 -0.25254.3821.000 31.10ANISOU 2151 C THR308 5251 2520 4044 -768 16279ATOM2152 O THR308 10.610 -1.29253.7181.000 31.44ANISOU 2152 O THR308 4573 2676 4696 -457 -1745 -40ATOM2153 CB THR308 12.615 1.279 54.3781.000 23.51ANISOU 2153 CB THR308 3718 2086 3131 413-694 542ATOM2154 OG1 THR308 13.195 2.410 53.7051.000 23.61ANIS0U 2154 OG1 THR308 2711 2503 3754 153437 -9ATOM2155 CG2 THR308 13.573 0.141 54.1171.000 26.37ANIS0U 2155 CG2 THR308 4427 2796 2796 927-329 -18ATOM2156 N SER309 10.066 -0.15655.5961.000 28.39ANISOU 2156 N SER309 3759 2774 4252 -192 1300ATOM2157 CA SER309 9.488 -1.33556.2381.000 34.69ANISOU 2157 CA SER309 6110 3146 3925 -1066 -1089 1626ATOM2158 C SER309 8.109 -1.73755.7241.000 41.41ANISOU 2158 C SER309 6442 3910 5383 -2171 -1170 2144ATOM2159 O SER309 7.672 -2.88455.9521.000 57.05ANISOU 2159 O SER309 113895141 5146 -4907 -2077 2027ATOM2160 CB SER309 9.450 -1.10457.7551.000 31.61ANISOU 2160 CB SER309 4863 2958 4188 -483 368 962ATOM2161 OG SER309 8.485 -0.13558.1071.000 38.99ANISOU 2161 OG SER309 4731 3477 6604 313-2249 -496ATOM2162 N LYS310 7.391 -0.86855.0321.000 47.69ANISOU 2162 N LYS310 5502 5577 7040 -539 -1369 1583ATOM2163 FE IUM312 8.574 13.46654.0551.000 11.05ANISOU 2163 FE IUM312 1690 1156 1351 -101 -237 71ATOM2164 C1 AKG313 5.987 14.81554.6121.000 19.65ANISOU 2164 C1 AKG313 2777 2119 2572 258-117 556ATOM2165 O1 AKG313 4.799 15.24054.6591.000 20.82ANISOU 2165 O1 AKG313 2957 2293 2659 514-234 264ATOM2166 O2 AKG313 6.643 14.14453.7871.000 17.79ANISOU 2166 O2 AKG 313 24071765 2587 74 -377 429ATOM2167 C2 AKG 313 6.867 15.17855.8441.000 20.08ANISOU 2167 C2 AKG 313 19972566 3068 -528 419 -399ATOM2168 O5 AKG 313 7.982 14.66155.8211.000 17.60ANISOU 2168 O5 AKG 313 22892066 2334 -314 226 -252ATOM2169 C3 AKG 313 6.272 16.08056.8721.000 21.69ANISOU 2169 C3 AKG 313 27511910 3581 24062-327ATOM2170 C4 AKG 313 7.318 16.74157.7161.000 21.50ANISOU 2170 C4 AKG 313 32461761 3160 199-143 -185ATOM2171 C5 AKG 313 6.923 17.81658.6721.000 22.58ANISOU 2171 C5 AKG 313 31221840 3618 755-495 -313ATOM2172 O3 AKG 313 7.754 18.59159.1241.000 27.48ANISOU 2172 O3 AKG 313 35812470 4389 -34602 -1266ATOM2173 O4 AKG 313 5.660 17.88958.9991.000 28.55ANISOU 2173 O4 AKG 313 31912809 4846 612-246 -1148ATOM2174 S SO4 401 11.676 0.439 24.9421.000 40.14ATOM2175 O1 SO4 401 11.293 0.826 26.3211.000 33.12ATOM2176 O2 SO4 401 12.501 -0.82925.0141.000 35.79ATOM2177 O3 SO4 401 10.430 0.189 24.1291.000 54.89ATOM2178 O4 SO4 401 12.500 1.520 24.3291.000 44.80ATOM2179 OW HOH 501 -6.455 10.21944.3191.000 14.29ATOM2180 OW HOH 502 -10.52018.61250.5601.000 12.86ATOM2181 OW HOH 503 -8.644 16.90747.8581.000 16.83ATOM2182 OW HOH 504 -10.31320.80043.0741.000 16.10ATOM2183 OW HOH 505 -6.051 19.19952.6021.000 16.38ATOM2184 OW HOH 506 -6.873 24.64247.1001.000 20.55ATOM2185 OW HOH 507 10.676 -4.17946.4061.000 27.41ATOM2186 OW HOH 508 -0.077 21.78640.8721.000 15.22ATOM2187 OW HOH 509 5.761 13.65646.0411.000 17.40ATOM2188 OW HOH 510 29.135 31.44951.9821.000 18.40ATOM2189 OW HOH 511 26.032 32.72452.7411.000 17.03ATOM2190 OW HOH 512 10.965 32.37146.0001.000 16.70ATOM2191 OW HOH 513 23.871 24.45758.6491.000 18.71ATOM2192 OW HOH 514 26.353 29.06350.3261.000 18.96ATOM2193 OW HOH 515 23.191 33.10653.1531.000 20.41ATOM2194 OW HOH 516 21.429 11.72155.3291.000 18.39ATOM2195 OW HOH 517 9.122 15.56753.5851.000 24.87ATOM2196 OW HOH 518 27.843 17.35253.4371.000 27.76ATOM2197 OW HOH 519 -14.41520.02944.4441.000 23.47ATOM2198 OW HOH 520 15.253 33.05051.7711.000 27.20ATOM2199 OW HOH 521 14.080 31.48644.3021.000 21.58ATOM2200 OW HOH 522 17.770 33.84253.5961.000 23.56ATOM2201 OW HOH 523 3.671 24.67336.1731.000 20.95ATOM2202 OW HOH 524 -15.68328.61852.5351.000 24.05ATOM2203 OW HOH 525 -5.386 20.41339.0131.000 26.85ATOM2204 OW HOH 526 10.417 27.94958.7781.000 28.33ATOM2205 OW HOH 527 23.165 19.59262.2021.000 29.36ATOM2206 OW HOH 528 23.736 10.55055.7371.000 24.02ATOM2207 OW HOH 529 -1.662 28.65042.4851.000 21.62ATOM2208 OW HOH 530 -4.689 10.17746.5111.000 31.65ATOM2209 OW HOH 531 1.545 35.65750.8661.000 19.59ATOM2210 OW HOH 532 0.980 22.68736.8181.000 30.57ATOM2211 OW HOH 533 -12.45016.84856.0711.000 28.42ATOM2212 OW HOH 534 -9.418 16.13951.3641.000 22.60ATOM2213 OW HOH 535 32.711 25.81643.1161.000 31.44ATOM2214 OW HOH 536 27.068 24.58755.4681.000 23.32ATOM2215 OW HOH 537 13.523 11.83251.1991.000 10.73ATOM2216 OW HOH 538 8.513 16.15835.0741.000 12.26ATOM2217 OW HOH 539 0.922 2.590 35.0581.000 14.79ATOM2218 OW HOH 540 -1.548 3.709 34.4841.000 14.25ATOM2219 OW HOH 541 11.711 16.89830.4161.000 17.84ATOM 2220 OW HOH 542 15.389 11.536 32.065 1.000 17.88ATOM 2221 OW HOH 543 18.496 6.995 52.191 1.000 17.47ATOM 2222 OW HOH 544 19.848 22.580 35.334 1.000 17.28ATOM 2223 OW HOH 545 -0.387 4.787 41.967 1.000 13.22ATOM 2224 OW HOH 546 23.502 12.662 35.308 1.000 18.14ATOM 2225 OW HOH 547 10.332 25.236 33.926 1.000 19.05ATOM 2226 OW HOH 548 21.447 20.605 34.090 1.000 17.24ATOM 2227 OW HOH 549 8.164 7.685 27.077 1.000 25.40ATOM 2228 OW HOH 550 14.393 -5.127 40.321 1.000 15.88ATOM 2229 OW HOH 551 12.873 29.356 39.662 1.000 16.45ATOM 2230 OW HOH 552 11.974 24.144 58.426 1.000 19.71ATOM 2231 OW HOH 553 17.521 7.949 33.182 1.000 17.90ATOM 2232 OW HOH 554 3.401 2.691 43.340 1.000 23.76ATOM 2233 OW HOH 555 18.669 28.057 40.079 1.000 18.44ATOM 2234 OW HOH 556 10.827 12.928 30.017 1.000 19.57ATOM 2235 OW HOH 557 20.630 16.270 66.466 1.000 20.84ATOM 2236 OW HOH 558 11.315 20.266 64.044 1.000 21.62ATOM 2237 OW HOH 559 26.277 14.516 43.946 1.000 16.22ATOM 2238 OW HOH 560 9.616 15.488 32.365 1.000 19.40ATOM 2239 OW HOH 561 8.888 4.903 27.857 1.000 22.74ATOM 2240 OW HOH 562 20.496 -1.851 42.511 1.000 22.98ATOM 2241 OW HOH 563 17.033 29.415 38.332 1.000 26.36ATOM 2242 OW HOH 564 18.595 6.141 37.697 1.000 25.10ATOM 2243 OW HOH 565 22.446 13.893 31.420 1.000 29.00ATOM 2244 OW HOH 566 6.586 3.577 28.350 1.000 27.82ATOM 2245 OW HOH 567 6.250 20.077 30.961 1.000 23.27ATOM 2246 OW HOH 568 7.341 16.113 31.186 1.000 28.59ATOM 2247 OW HOH 569 16.090 32.070 42.552 1.000 33.08ATOM 2248 OW HOH 570 11.500 28.806 37.258 1.000 25.17ATOM 2249 OW HOH 571 12.901 26.768 58.591 1.000 28.58ATOM 2250 OW HOH 572 -17.071 17.043 50.450 1.000 28.82ATOM 2251 OW HOH 573 25.262 7.705 37.199 1.000 39.05ATOM 2252 OW HOH 574 32.884 26.440 51.734 1.000 29.03ATOM 2253 OW HOH 575 -1.199 19.088 42.527 1.000 14.86ATOM 2254 OW HOH 576 -4.389 33.026 63.392 1.000 29.56ATOM 2255 OW HOH 577 17.569 25.732 32.249 1.000 20.62ATOM 2256 OW HOH 578 -19.107 12.822 67.516 1.000 22.35ATOM 2257 OW HOH 579 29.333 19.198 51.975 1.000 22.51ATOM 2258 OW HOH 580 27.950 27.635 51.903 1.000 25.40ATOM 2259 OW HOH 581 -21.085 14.501 68.535 1.000 21.19ATOM 2260 OW HOH 582 1.529 17.378 33.953 1.000 25.29ATOM 2261 OW HOH 583 9.138 20.887 66.894 1.000 33.92ATOM 2262 OW HOH 584 -11.896 19.091 44.780 1.000 17.48ATOM 2263 OW HOH 585 6.382 12.597 43.347 1.000 22.09ATOM 2264 OW HOH 586 17.762 21.268 29.046 1.000 20.79ATOM 2265 OW HOH 587 -11.500 25.438 41.729 1.000 29.68ATOM 2266 OW HOH 588 7.877 1.046 29.689 1.000 27.70ATOM 2267 OW HOH 589 27.985 13.540 42.235 1.000 25.91ATOM 2268 OW HOH 590 1.276 14.852 34.021 1.000 20.41ATOM 2269 OW HOH 591 24.622 24.179 41.242 1.000 26.77ATOM 2270 OW HOH 592 0.404 14.096 36.006 1.000 27.92ATOM 2271 OW HOH 593 -2.835 36.981 57.827 1.000 31.86ATOM 2272 OW HOH 594 3.276 0.788 39.940 1.000 32.07ATOM 2273 OW HOH 595 11.025 -8.794 31.468 1.000 27.18ATOM 2274 OW HOH 596 6.301 2.276 42.639 1.000 29.74ATOM 2275 OW HOH 597 29.302 16.146 62.924 1.000 43.75ATOM 2276 OW HOH 598 19.039 20.964 67.011 1.000 30.85ATOM 2277 OW HOH 599 8.380 22.088 64.518 1.000 42.62ATOM 2278 OW HOH 600 21.480 10.826 34.742 1.000 25.74ATOM 2279 OW HOH 601 -2.907 21.956 38.566 1.000 30.92ATOM 2280 OW HOH 602 -3.928 29.841 43.352 1.000 43.96ATOM 2281 OW HOH 603 2.885 21.563 34.437 1.000 33.10ATOM 2282 OW HOH 604 11.801 6.043 25.270 1.000 38.18ATOM 2283 OW HOH 605 -1.019 17.197 40.472 1.000 18.48ATOM 2284 OW HOH 606 18.382 23.349 68.110 1.000 22.54ATOM 2285 OW HOH 607 -8.141 8.137 45.609 1.000 17.64ATOM 2286 OW HOH 608 5.022 2.667 51.700 1.000 24.29ATOM 2287 OW HOH 609 17.557 10.755 33.490 1.000 21.94ATOM 2288 OW HOH 610 11.222 1.201 49.675 1.000 20.61ATOM 2289 OW HOH 611 4.243 35.047 50.509 1.000 22.18ATOM 2290 OW HOH 612 11.103 4.031 56.082 1.000 22.08ATOM 2291 OW HOH 613 11.366 31.522 36.791 1.000 32.32ATOM 2292 OW HOH 614 -21.189 24.787 52.739 1.000 31.83ATOM 2293 OW HOH 615 7.847 -1.491 30.674 1.000 24.77ATOM 2294 OW HOH 616 19.041 11.937 31.445 1.000 25.97ATOM 2295 OW HOH 617 6.221 29.879 40.410 1.000 29.24ATOM 2296 OW HOH 618 17.266 5.933 35.280 1.000 23.72ATOM 2297 OW HOH 619 5.983 -7.215 28.510 1.000 28.19ATOM 2298 OW HOH 620 22.574 8.129 57.639 1.000 30.97ATOM 2299 OW HOH 621 2.553 7.806 60.287 1.000 28.77ATOM 2300 OW HOH 622 29.939 25.812 51.234 1.000 34.00ATOM 2301 OW HOH 623 2.205 34.823 53.632 1.000 25.88ATOM 2302 OW HOH 624 18.091 13.838 67.343 1.000 28.46ATOM 2303 OW HOH 625 8.342 3.195 58.475 1.000 26.84ATOM 2304 OW HOH 626 -16.086 18.427 42.790 1.000 31.11ATOM 2305 OW HOH 627 -2.098 13.445 35.620 1.000 27.48ATOM 2306 OW HOH 628 0.481 30.471 42.834 1.000 32.55ATOM 2307 OW HOH 629 13.368 33.845 42.899 1.000 28.70ATOM 2308 OW HOH 630 -13.792 14.642 51.533 1.000 25.58ATOM 2309 OW HOH 631 3.299 1.461 29.242 1.000 39.62ATOM 2310 OW HOH 632 -16.012 20.690 46.705 1.000 27.75ATOM 2311 OW HOH 633 19.606 8.142 31.259 1.000 27.02ATOM 2312 OW HOH 634 5.077 7.954 57.205 1.000 30.59ATOM 2313 OW HOH 635 -1.502 6.963 45.877 1.000 35.68ATOM 2314 OW HOH 636 9.974 17.449 38.804 1.000 21.84ATOM 2315 OW HOH 637 -22.829 12.836 67.228 1.000 25.04ATOM 2316 OW HOH 638 6.275 34.333 39.722 1.000 25.88ATOM 2317 OW HOH 639 2.248 19.798 56.051 1.000 26.67ATOM 2318 OW HOH 640 -20.552 17.013 67.454 1.000 31.34ATOM 2319 OW HOH 641 9.298 16.570 28.911 1.000 29.96ATOM 2320 OW HOH 642 -1.732 11.113 60.074 1.000 28.13ATOM 2321 OW HOH 643 34.157 23.604 44.657 1.000 36.36ATOM 2322 OW HOH 644 24.298 20.199 33.576 1.000 34.90ATOM 2323 OW HOH 645 13.803 -4.667 31.570 1.000 32.66ATOM 2324 OW HOH 646 6.295 -2.594 29.009 1.000 34.61ATOM 2325 OW HOH 647 5.623 37.039 49.318 1.000 28.08ATOM 2326 OW HOH 648 -18.805 19.286 46.868 1.000 38.32ATOM 2327 OW HOH 649 16.026 35.829 49.382 1.000 34.45ATOM 2328 OW HOH 650 -12.187 28.769 45.330 1.000 27.36ATOM 2329 OW HOH 651 21.344 5.778 55.101 1.000 27.43ATOM 2330 OW HOH 652 -1.848 2.125 32.240 1.000 32.02ATOM 2331 OW HOH 653 -14.568 18.811 55.775 1.000 29.95ATOM 2332 OW HOH 654 -8.655 26.254 38.301 1.000 32.07ATOM 2333 OW HOH 655 18.836 13.542 28.102 1.000 32.24ATOM 2334 OW HOH 656 16.217 14.669 25.619 1.000 33.35ATOM 2335 OW HOH 657 28.678 14.477 38.043 1.000 30.94ATOM 2336 OW HOH 658 -11.834 15.408 53.330 1.000 33.25ATOM 2337 OW HOH 659 -1.317 38.273 59.599 1.000 34.45ATOM 2338 OW HOH 660 8.784 13.918 28.681 1.000 33.62ATOM 2339 OW HOH 661 -3.058 14.508 47.405 1.000 28.79ATOM 2340 OW HOH 662 10.968 33.651 38.533 1.000 36.21ATOM 2341 OW HOH 663 28.960 21.602 53.665 1.000 29.25ATOM 2342 OWHOH 664 -10.709 26.80839.1751.000 42.71ATOM 2343 OWHOH 665 17.790 7.093 55.0231.000 30.29ATOM 2344 OWHOH 666 6.40424.86529.8481.000 34.55ATOM 2345 OWHOH 667 -15.418 19.77758.3411.000 33.82ATOM 2346 OWHOH 668 0.0000.000 37.2590.330 49.90ATOM 2347 OWHOH 669 19.652 24.61033.6601.000 31.77ATOM 2348 OWHOH 670 17.188 9.619 29.9501.000 29.94ATOM 2349 OWHOH 671 17.708 2.958 28.3381.000 34.94ATOM 2350 OWHOH 672 -0.059 3.652 30.0791.000 32.23ATOM 2351 OWHOH 673 29.037 20.92356.1531.000 28.52ATOM 2352 OWHOH 674 -15.435 31.08853.7951.000 35.61ATOM 2353 OWHOH 675 -12.846 21.22061.8561.000 38.79ATOM 2354 OWHOH 676 10.299 39.66649.5541.000 40.30ATOM 2355 OWHOH 677 -5.921 28.82241.5211.000 34.01ATOM 2356 OWHOH 678 6.02939.99146.0941.000 42.69ATOM 2357 OWHOH 679 35.052 23.15652.3561.000 40.17ATOM 2358 OWHOH 680 -12.008 38.35551.6011.000 35.18ATOM 2359 OWHOH 681 3.06113.04753.1521.000 35.17ATOM 2360 OWHOH 682 1.3792.075 27.5321.000 46.38ATOM 2361 OWHOH 683 -0.516 -2.48037.6861.000 21.77ATOM 2362 OWHOH 684 4.56710.31043.5031.000 24.86ATOM 2363 OWHOH 685 19.443 5.558 61.1331.000 36.06ATOM 2364 OWHOH 686 3.20529.49940.6561.000 36.99ATOM 2365 OWHOH 687 32.498 16.77443.4471.000 41.18ATOM 2366 OWHOH 688 28.166 23.11357.5931.000 35.56ATOM 2367 OWHOH 689 -17.023 23.22046.7591.000 30.05ATOM 2368 OWHOH 690 15.567 7.782 28.9101.000 32.51ATOM 2369 OWHOH 691 11.780 30.28757.2031.000 33.34ATOM 2370 OWHOH 692 24.449 12.69932.4001.000 34.99ATOM 2371 OWHOH 693 26.200 25.00557.9181.000 39.38
权利要求
1．具有本文结构A或结构B的X射线坐标定义的结构的脱乙酰氧基头孢菌素C合酶(DAOCS)。
2．与金属，例如铁或铅形成复合体形式的DAOCS，并可选可不选地在在底物和/或底物类似物或抑制剂的存在下，具有由本文X射线坐标定义的结构。
3．权利要求2的DAOCS，其中底物为青霉素N，青霉素G，2-酮戊二酸或双氧，且抑制剂选自N-草酰氨基酸，吡啶羧酸类和一氧化二氮。
4．DAOCS的三维结构在DAOCS或其它相关2-酮戊二酸依赖性酶的修饰中的应用。
5．权利要求4所述的应用，其中相关的2-酮戊二酸依赖性酶是DACS，DAOC/DACS或参与将7α-甲氧基引入头孢霉素C的加氧酶。
6．权利要求5应用，用于对DAOCS，DACS或DAOC/DACS进行修饰，以使它们较野生型酶更有效地接受非天然底物。
7．权利要求5应用，用于对DAOCS，DACS，DAOC/DACS进行修饰，以使它们将天然底物转变为药物或药物制备中有用的中间体。
8．如权利要求6的应用，其中非天然底物为青霉素，包括青霉素G，青霉素V，6-氨基青霉烷酸，阿莫西林，或具苯基甘氨酸或对羟苯基甘氨酸侧链的青霉素类。
9．权利要求6的应用，其中非天然底物是头孢菌素。
10．权利要求6的应用，其中非天然底物是一种氨基酸，包括蛋白原氨基酸，或一种肽。
11．权利要求6-8任一项所述的应用，其中青霉素G，青霉素V，其它非天然底物或青霉素N被转换为头孢菌素或外亚甲基头孢菌素。
12．一种与DAOCS具有如本文所定义的显著序列相似性的酶，其中青霉素N或DAOC的侧链结合位点经修饰而且至少一个下列位点的至少一个氨基酸残基转变为另外一个氨基酸残基或被缺失Thr72，Arg74，Arg75，Glu156，Leu158，Arg160，Arg162，Leu186，Ser187，Phe225，Phe264，Arg266，Asp301，Tyr302，Val303，Asn304；和/或至少一个额外的氨基酸残基插入到区域300-311；前提是与以上氨基酸相互作用的其它残基酸可能也发生改变以配合上面之一改变。
13．一种与DAOCS具有如本文定义的显著序列相似性的酶，其中青霉素N或DAOC的青霉素/头孢霉素结合位点经过修饰，且至少一个以下的氨基酸残基被改变或被缺失Ile88，Arg160，Arg162，Phe164，Met180，Thr190，Ile192，Phe225，Pro241，Val245，Val262，Phe264，Ile305，Arg306，Arg307，和/或至少一个额外氨基酸残基插入在区域300-311；前提是与以上氨基酸相互作用的其它残其它残基也发生改变以配合上面之一的改变。
14．权利要求12或权利要求13的酶，它是DAOCS或DACS或DAOC/DACS的突变体。
15．权利要求12-14中任一项所述的酶，其中青霉素N或DAOC的青霉素/头孢菌素的侧链以及结合位点经过修饰且权利要求12和13中所限定残基的至少一种发生改变或缺失。
16．权利要求12-15任一项所述的酶，其中引入两个或更多互补突变以产生或缺失结合相互作用，包括氢键，静电，或疏水相互作用。
17．编码权利要求12-16任一项的酶的基因。
18．在发酵条件下能够表达权利要求17的基因的微生物。
19．权利要求18的微生物在青霉素或头孢菌素(包括头孢烯(cepham))家族的β-内酰胺类的生产中的应用。
20．权利要求19所述的应用，其中微生物含有青霉素和头孢菌素生物合成途径中其它经修饰的酶，包括异青酶素N合酶，酰胺水解酶/乙酰转移酶，或L-δ-(氨基己二酰基)-L-半胱氨酸-D-缬氨酸(ACV)合酶。
21．一种方法，包括运用DAOCS的三维结构确定或预测另外相关的2-酮戊二酸依赖的酶或来自非青霉素和头孢菌素生物合成途径的相关酶的结构，以及运用获得的结构信息修饰其它酶或设计其它酶的抑制剂。
22．权利要求21的方法，其中所述其它相关的2-酮戊二酸依赖的酶或相关的酶是1-氨基环丙烷-1-羧化物氧化酶，赤霉素C-20氧化酶，黄酮合酶，黄烷酮3β-羟化酶，天仙子胺6β-羟化酶，脯氨酰4-羟化酶，脯氨酰3-羟化酶，天冬氨酰羟化酶，赖氨酰羟化酶，脯氨酸羟化酶，γ-丁酰甜菜碱羟化酶，除草剂抗性机制中的酶，棒烷酸(Clavaminate)合酶，参与碳青霉烯生物合成的加氧酶，来自丁香假单胞菌的乙烯形成酶，对羟苯基丙酮酸双加氧酶，和参与人肝过氧化物酶体中叶绿醇氧化的加氧酶。
23．权利要求21或22中的方法，春中所述的其它酶通过缺失，添加或改变而进行修饰；修饰发生在权利要求12或13定义的一或多个位点；或使用以下信息设计抑制剂Asp185，His183和His243作为铁的配体；Arg258和Ser260和Fe与2-酮戊二酸结合；Met180，Phe225，Leu31和Val245靠近铁结合位点；Tyr33，Arg160，Arg162，Phe164，Ile192，Gln194，Leu204，Leu223，Leu215对于与2-酮戊二酸结合的活性位点某些部分的构建十分重要；Arg160和Arg162对于与氨基酸或肽衍生的底物结合十分重要。
24．权利要求21-23任一项所述的方法，其中所述其它酶是脯氨酰4-羟化酶，脯氨酰3-羟化酶，天冬氨酰羟化酶，或赖氨酰羟化酶，且抑制剂被应用于对人疾病包括纤维性疾病肝硬变和关节炎的治疗上。
25．权利要求21-23任一项所述的方法，其中所述的其它相关酶是对羟甲基丙酮酸双加氧酶，且抑制剂被运用于对某种遗传病的治疗中。
26．权利要求21-23任一项所述的方法，其中所述的其它酶参与除草剂抗性且其信息被用于设计新除草剂以克服抗性问题。
全文摘要
本文描述了脱乙酰氧基头孢菌素C合酶(DAOCS)的三维晶体结构。X射线坐标提供了DAOCS结构中的氨基酸的精确三维信息。这其中的某些氨基酸与铁和/或底物形成复合物。来自结构的信息用于修饰包括DAOCS,脱乙酰头孢菌素C合酶DAOC/DACS的头孢菌素生物合成途径的酶,经修饰使它们接受非天然底物(例青霉素G,V),从而促进β－内酰胺抗生素的产生。这些结构可用于预测其它2－酮戊二酸依赖的酶的结构,由此使得能设计抑制剂,以及用于例如氧化的氨基酸/肽的生产的新催化剂。在此提出并例举了对氨基酸残基的具体修饰。
文档编号C12N1/21GK1284997SQ9881379
公开日2001年2月21日 申请日期1998年12月24日 优先权日1997年12月24日
发明者C·J·肖菲尔德, J·E·巴尔德文, P·L·罗尔克, M·D·罗伊德, K·哈洛斯, I·安德松, J·哈杜, A·S·特尔维斯查范舍尔廷加, K·瓦勒加德, S·拉马斯瓦米 申请人:埃西斯创新有限公司